RSC – RSC Med. Chem. latest articles- An estrogen receptor β‑targeted near-infrared probe for theranostic imaging of prostate cancer December 11, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00767K, Research ArticleJunhong Dai, Yihe Wu, Xiaofei Deng, Haibing Zhou, Chune DongEstrogen receptor β (ERβ) is aberrantly expressed in castration -resistant prostate cancer (CRPC), therefore, a diagnostic and therapeutic ERβ probe not only helps to reveal the complex role of ERβ...The content of this RSS Feed (c) The Royal […]Junhong Dai
- Development of coumarin-inspired bifunctional hybrids as a new class of anti-Alzheimer’s agents with potent in vivo efficacy December 11, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00782D, Research ArticleAtamjit Singh, Kirandeep Kaur, Saroj Arora, Aman Sharma, Karanvir Singh, Pallvi Mohana, Jignesh Prajapati, Uttam Kaur, Dweipayan Goswami, Renu Chadha, Preet Mohinder Singh BediKeeping in mind the multifactorial and complex nature of Alzheimer’s disease and the requirement of optimum multifunctional anti-Alzheimer’s agent. A series of triazole tethered […]Atamjit Singh
- Sulphonyl thiourea compounds containing pyrimidine as dual inhibitors for I, II, IX, XII carbonic anhydrases and cancer cell lines: Synthesis, characterization and in silico studies December 11, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00816B, Research ArticleNguyen Dinh Thanh, Vu Ngoc Toan, Vu Minh TrangA novel sulphonyl thiourea derivatives (7a-m) containing 4,6-diarylpyrimidine moiety exhibited the remarkable dual inhibitory activity against the human carbonic anhydrase hCA IX and XII isoenzymes and some cancer cell lines....The content of this RSS Feed (c) The Royal Society […]Nguyen Dinh Thanh
- Probing Non Peptide Agonists Binding at Human Nociceptin/Orphanin FQ Receptor: A Molecular Modelling Study December 10, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00747F, Research ArticleMatteo Gozzi, Davide Malfacini, Valentina Albanese, Salvatore Pacifico, Delia Preti, Remo Guerrini, Girolamo Calò, Antonella CiancettaThe N/OFQ - NOP receptor is a fascinating peptidergic system holding the potential to be exploited for the development of, among others, analgesic drugs devoid of side effects associated with...The content of […]Matteo Gozzi
- Exploiting the DCAF16-SPIN4 interaction to identify DCAF16 ligands for PROTAC development December 6, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00681J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isabella Riha, Miguel Campos, Xiaokang Jin, Fiona Wang, Chenlu Zhang, Sara Fernandez Dunne, Benjamin Cravatt, Xiaoyu ZhangTraditional small molecule drugs often target protein activity directly, but challenges arise when proteins lack suitable […]Isabella Riha
- Thiazole-fused Androstenone and Ethisterone Derivatives: Potent β- and γ-Actin Cytoskeleton Inhibitors to Treat Melanoma Tumors December 6, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00719K, Research ArticleSanjay Adhikary, Subrata Roy, Shailesh Budhathoki, Siam Chowdhury, Abbey Stillwel, Alexei G. Basnakian, Alan J. Tackett, Nathan L. Avaritt, Mohamed Milad, Mohammad Abrar AlamMelanoma, the most fatal form of skin cancer, often becomes resistant to the current therapeutic approaches in most melanoma patients. To explore new treatment […]Sanjay Adhikary
- Recent advancements in the therapeutic approaches for Alzheimer's disease treatment: Current and future perspective December 6, 2024RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00630E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amit Sharma, Santosh Rudrawar, Sandip B. Bharate, Hemant R JadhavAlzheimer's disease (AD) is a complex, incurable neurological condition characterized by cognitive decline, cholinergic neuron reduction, and neuronal loss. Its exact pathology remains […]Amit Sharma
- Design and synthesis of novel cathepsin C inhibitors with anti-inflammatory activity December 3, 2024RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00730A, Research ArticleXiaobao Shen, Nan Li, Miao Liu, Xuanzheng Han, Yazhi Wang, Jingwen Jia, Fufang Wu, Hongwei Chen, Xinhua LiuCathepsin C (Cat C) is a potential candidate for addressing inflammatory conditions associated with neutrophil serine proteases (NSPs).To cite this article before page numbers are assigned, use the DOI form […]Xiaobao Shen
- Advances in the development of Wnt/β-catenin signaling inhibitors December 2, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00749B, Review ArticleMinami Fujita, Yosuke DemizuThe Wnt/β-catenin signaling pathway plays a critical role in various biological processes, including cell proliferation, differentiation, and tissue homeostasis. Aberrant activation of this pathway is strongly associated with the development...The content of this RSS Feed (c) The Royal Society of ChemistryMinami Fujita
- Hepatocyte targeting via the asialoglycoprotein receptor December 2, 2024RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00652F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Fabricio Ramírez-Cortés, Petra MénováThe asialoglycoprotein receptor (ASGPR) plays a crucial role in delivering therapeutics to hepatocytes. From nucleic acids to LYTACs and drugs, we explore the current state-of-the-art strategies for hepatocyte targeting […]Fabricio Ramírez-Cortés
- An estrogen receptor β‑targeted near-infrared probe for theranostic imaging of prostate cancer December 11, 2024
