RSC – RSC Med. Chem. latest articles- Design, synthesis, and anticancer evaluation of novel pyrrole–pyrazoline/chalcone hybrids: in vitro and computational insights into EGFR inhibition April 26, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00800J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mansour S. Alturki, Marwa F. Ahmed, Abdulaziz H. Al Khzem, Mohamed S. Gomaa, Mohammad Sarafroz, Nada Tawfeeq, Mashael M. Alharbi, Abdulaziz K. Al Mouslem, Mohammed F. Aldawsari, Wajin R. Alruwili, Shah Alam […]Mansour S. Alturki
- New Terpenyl-Cinnamoyl-Hydrazone Analogues of Cannabidiol with Potent Antinociceptive Effect April 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00185H, Research ArticleJoão Pedro Barros de Paiva, Anna Carolina Pereira Lontra, Rachel Marins Campos, Eduardo Araújo, Thaís Biondino Sardella Giorno, Mikaela Lucinda de Souza, Graziella Dos Reis Rosa Franco, Claudio Viegas, Jr., Patricia Dias FernandesIn this study, novel terpenyl-cinnamoyl-hydrazone analogs were synthesized and evaluated for antinociceptive potential in preclinical […]João Pedro Barros de Paiva
- Lead optimization of 5jc21 (CG13250), a quinolin-2(1H)-one-based inhibitor of the BRD4 member of the bromodomain and extraterminal (BET) family of proteins April 23, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01082A, Research ArticleJay Chauhan, Sarah Pogash, Makoto Yoshioka, Mithun Raje, Daniel Van Eker, Jeffrey W. Strovel, Steven Fletcher4,6-Disubstituted quinolinones are potent BRD4 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryJay Chauhan
- Design, synthesis and pharmacological evaluation of 3H-spiro[benzofuran-2,4′-piperidine] IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma April 23, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00025H, Research ArticleZhiwei Chen, Qi Zhang, Yun Chen, Yi Ning, Q-i Zhang, Mengxiao Zhang, Qiupei Liu, Yi Xue, Linjiang Tong, Jian Ding, Hua Xie, Wenhu DuanWe report the discovery of a new series of 3H-spiro[benzofuran-2,4′-piperidine] IRAK4 inhibitors as potential anti-DLBCL agents.To cite this article before page numbers are assigned, […]Zhiwei Chen
- Addressing Multidrug-resistant Bacterial Infections with Iridium-based Theragnostic Agents April 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00120C, Research ArticleRama Karn, Mahesmita Sahoo, Sayantani Biswas, Suravi Chauhan, Ajay Kumar Nag, Soham Basu, Srikanta Patra, Debasis MannaEffective strategies are essential for addressing bacterial infections caused by antimicrobial resistance (AMR). The increasing interest in transition-metal complexes stems from their fluorescence properties and diverse mechanisms of action against...The content […]Rama Karn
- Emerging Cellular Uptake Mechanisms of bRo5 PROTACs April 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00243A, Review ArticleToshihiko TashimaProteolysis-targeting chimeras (PROTACs) predominantly occupy beyond-Rule-of-5 (bRo5) chemical space, where the mechanisms governing their cellular uptake remain incompletely understood and are not captured by classical models of passive membrane diffusion....The content of this RSS Feed (c) The Royal Society of ChemistryToshihiko Tashima
- Pyrazole–triazole hybrids as kinase-triad inhibitors: a triple-target strategy for synergistic anticancer therapy April 21, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00022C, Research ArticleMahmoud S. Elkotamy, Mohamed K. Elgohary, Mariam M. Fakhry, Mohamed E. Albakri, Abdelrahman A. Naglah, Abdulrahman A. Almehizia, Ahmed M. Naglah, Mohamed Fares, Haytham O. Tawfik, Wagdy M. Eldehna, Hatem A. Abdel-AzizThe ongoing issue of drug resistance and the lack of specificity in existing cancer treatments highlight […]Mahmoud S. Elkotamy
- A new class of Indole-based HDAC8 inhibitors as potential anti-lung cancer agents: In silico design, synthesis, biological assessment and binding interaction analysis April 21, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00194G, Research ArticleSAMIMA KHATUN, Venkatesh Muthukumar, Ambati Himaja, Indrasis Dasgupta, Kalpataru Das, Balaram Ghosh, Shovanlal GayenA novel series of indole-based hydroxamic acids was designed, synthesized, and evaluated as promising HDAC8 inhibitors for lung cancer therapy. In silico analyses, including classification-based QSAR, chemical space networks, and...The content of this RSS […]SAMIMA KHATUN
- Regioselective Triclocarban-Catalyzed Synthesis of Spiroindeno- and Spirooxindolo-Pyrrolizidines with Apoptosis Induction in MCF-7 Cells April 21, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00132G, Research ArticleV Rukyanaik, Samata Pradhan, Chandraiah Godugu, Srinu Tothadi, Kadiyam Rama Krishna, Ravinder Pawar, Srinivas BasavojuDesign of new molecules from known structural motifs via [3+2] cycloaddition is a widely used strategy in modern drug discovery. Herein, an efficient, eco-friendly synthesis of spiroindeno- and spirooxindolo-pyrrolizidine derivatives...The content of this […]V Rukyanaik
- Synthesis-guided design and discovery of alkylated indoles with antibacterial activity against MRSA April 20, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00221H, Research ArticleAuqib Rashid, Vishwani Jamwal, Bilal A Bhat, KULJIT SINGH, Showkat RashidSubstantially high morbidity and mortality rates are associated with antimicrobial resistance (AMR), which poses an alarming challenge to global healthcare. The causative, drug-resistant superbugs (headed by Staphylococcus aureus) adopt multiple...The content of this RSS Feed (c) The […]Auqib Rashid
- Design, synthesis, and anticancer evaluation of novel pyrrole–pyrazoline/chalcone hybrids: in vitro and computational insights into EGFR inhibition April 26, 2026
