RSC – RSC Med. Chem. latest articles- Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents April 22, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00053F, Research ArticleZhen Wang, Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo, Yan Song, Yan Zou, Peichao Zhang, Gui-Ge Hou, Qingguo Meng, Qingjie Zhao, Xiaoyun ChaiLCA, a dibenzylbutane lignan extracted from the roots of traditional medicinal plant Litsea cubeba (Lour.) Pers., has demonstrated promising anti-inflammatory activity and low cytotoxicity. […]Zhen Wang
- Can Large Language Models Predict Antimicrobial Peptide Activity and Toxicity? April 22, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00159A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Markus Orsi, Jean-Louis ReymondAntimicrobial peptides (AMPs) are naturally occurring or designed peptides up to a few tens of amino acids which may help address the antimicrobial resistance crisis. However, their clinical development […]Markus Orsi
- Design, synthesis, molecular docking and anti-proliferative activity of novel phenothiazine containing imidazo[1,2-a]pyridine derivatives against MARK4 protein April 18, 2024RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00059E, Research ArticleAvijit Bhakta, Sayeed Mukhtar, Saleha Anwar, Shaista Haider, Mohammed Issa Alahmdi, Humaira Parveen, Meshari A. Alsharif, Mohmmad Younus Wani, Anindita Chakrabarty, Md. Imtaiyaz Hassan, Naseem AhmedA series of novel phenothiazine-containing imidazo[1,2-a]pyridine derivatives were designed and synthesized under metal-free conditions in excellent yield.To cite this article before page […]Avijit Bhakta
- The importance of tyrosines in multimers of cyclic RGD nonapeptides: towards αvβ6-integrin targeted radiotherapeutics April 18, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00073K, Research ArticleNeil Gerard Quigley, Maximilian Zierke, Stefanie Ludwig, Frauke Richter, Nghia Nguyen, Falco Reissig, Jakub Šimeček, Susanne Kossatz, Johannes NotniIn a recent paper in this journal (RSC Med. Chem., 2023, 14, 2429), we described an unusually strong impact of regiospecific exchange of phenylalanines by tyrosines in 10 gallium-68-labeled […]Neil Gerard Quigley
- Cytotoxicity of Phosphoramidate, Bis-amidate and CycloSal Prodrug Metabolites Against Tumour and Normal Cells April 17, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00115J, Research ArticleRebecca Elizabeth Farrell, Harrison Steele, Ryan Middleton, Danielle Skropeta, Guo-Jun LiuPhosphonate and phosphate prodrugs are integral to enhancing drug permeability, but the potential toxicity of their metabolites requires careful consideration. This study evaluates the impact of widely used phosphoramidate, bis-amidate,...The content of this RSS Feed (c) The […]Rebecca Elizabeth Farrell
- Synthetic 18F labeled biomolecules that are selective and promising for PET imaging: Major advances and applications April 16, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00033A, Review ArticleManisha Lamba, Prasoon Raj Singh, Anupam Bandyopadhyay, Avijit GoswamiThe concept of positron emission tomography (PET) based imaging was developed more than 40 years ago. It has been a widely adopted technique for detecting and staging numerous diseases in...The content of this RSS Feed (c) The Royal Society […]Manisha Lamba
- Potential of covalently linked tamoxifen hybrids for cancer treatment: Recent update April 16, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D3MD00632H, Review ArticleShagufta ., Irshad Ahmad, Donna J. Nelson, Maheen Imtiaz Hussain, Noora Ali NasarCancer is a complex disease and the second leading cause of death globally, and breast cancer is still a leading cause of cancer death in women. Tamoxifen is the most...The content of this RSS Feed […]Shagufta .
- Unveiling Sultam in Drug Discovery: Spotlight on the Underexplored Scaffold April 15, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D3MD00653K, Review ArticleYie Kie Chong, Yee Swen Ong, Keng Yoon YeongDecades ago, the application of cyclic sulfonamide (sultam) and its derivatives primarily focused on their antibacterial properties. However, recent years have seen a shift in research attention towards exploring their...The content of this RSS Feed (c) The Royal Society […]Yie Kie Chong
- Correction: Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer April 14, 2024RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD90013H, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yuejie Zhu, Xiang Li, Qi Zhang, Xiantao Yang, Xudong Sun, Yi Pan, Xia Yuan, Yuan Ma, Bo Xu, Zhenjun YangTo cite this article before page numbers are assigned, use the DOI form of […]Yuejie Zhu
- Amine-containing Donepezil Analogues as Potent Acetylcholinesterase Inhibitors with Increased Polarity April 11, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D3MD00635B, Research ArticleJonas Kaltbeitzel, Christian Kersten, Peter R WichFunctional dyspepsia (FD) is a gastrointestinal disorder characterized by postprandial fullness, upper abdominal bloating, and early satiation. Peripheral acetylcholinesterase (AChE) inhibitors such as acotiamide have shown efficacy in FD treatment,...The content of this RSS Feed (c) The Royal Society of ChemistryJonas Kaltbeitzel
- Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents April 22, 2024
