RSC – RSC Med. Chem. latest articles- Novel benzenesulfonamides containing dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity October 3, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Sükru BeydemirA series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized and synthesized as human carbonic anhydrase (hCA) inhibitors. The synthesized small structures, numbered 7a through 7o, exhibited moderate...The content of this […]Aida Buza
- Pathogenesis of Alzheimer's Disease and Therapeutic Strategies Involving Traditional Chinese Medicine October 2, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00660G, Review ArticleJinfei Yang, Shutang LiAlzheimer's disease (AD) is a prevalent degenerative disorder affecting the central nervous system of the elderly. Patients primarily manifest cognitive decline and non-cognitive neuro-psychiatric symptoms. Currently, western medications for AD...The content of this RSS Feed (c) The Royal Society of ChemistryJinfei Yang
- A novel, glutathione-activated prodrug of Pimasertib loaded in liposomes for targeted cancer therapy October 2, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00517A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Arianna Amenta, Susanna Comi Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca RePimasertib, a potent antiproliferative drug, has been extensively studied for the treatment of cancers […]Arianna Amenta
- Discovery of N-Substituted-2-Oxoindolin Benzoylhydrazines as c-MET/SMO Modulators in EGFRi-Resistant Non-Small Cell Lung Cancer October 2, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, CATERINA DE ROSA, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Morgillo Floriana, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause […]Stefano Tomassi
- Developing peptide-based fusion inhibitors as an antiviral strategy utilizing Coronin 1 as a template October 1, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00523F, Research ArticleManbit Subhadarsi Panda, Bushra Qazi, Vaishali Vishwakarma, Gourab Prasad Pattnaik, Sourav Haldar, Hirak ChakrabortyEnveloped viruses can enter the host cells by endocytosis and subsequently fuse with the endosomal membranes, or fuse with the plasma membrane at the cell surface. The crucial stage of...The content of this RSS […]Manbit Subhadarsi Panda
- Novel curcumin-based analogues as potential VEGFR2 inhibitors with promising metallic loading nanoparticles: synthesis, biological evaluation, and molecular modelling investigation September 26, 2024RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00574K, Research ArticleAsmaa S. A. Yassen, Sherief M. Abdel-Wahab, Khaled M. Darwish, Mohamed S. Nafie, Reda F. A. Abdelhameed, Gharieb S. El-Sayyad, Ahmed I. El-Batal, Khadiga M. Attia, Hosam A. Elshihawy, Ranza ElrayessTargeting VEGFR2, compound 4e and its Fe2O3-humic acid-NPs could be further developed as promising anti-breast cancer agents.To […]Asmaa S. A. Yassen
- Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication September 26, 2024RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00454J, Research ArticleDavid A. Davis, Ashwin Nair, Yana Astter, Emma Treco, Brian Peyser, Rick Gussio, Tam Nguyen, Brett Eaton, Elena Postnikova, Michael Murphy, Prabha Shrestha, Haydar Bulut, Shin-Ichiro Hattorri, Hiroaki Mitsuya, Robert YarchoanTixocortol, the active component in a nasal spray, inhibits SARS-CoV-2 main protease and viral replication. This highlights […]David A. Davis
- New Anti-ovarian cancer quinolone derivatives acting by modulating microRNA processing machinery September 26, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00649F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tommaso Felicetti, Nicola Di Iacovo, Maria Agnese Della Fazia, Danilo Piobbico, Stefania Pieroni, Martina Pacetti, Jialing Yu, Yilun Sun, Serena Massari, Maria Letizia Barreca, Stefano Sabatini, Oriana Tabarrini, Violetta Cecchetti, Fei Wang, […]Tommaso Felicetti
- Assessing the biocompatibility and stability of CeO2 nanoparticle conjugates with azacrowns for use as radiopharmaceuticals September 26, 2024RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00515E, Research ArticleSofia Khabirova, Mikhail Menshikov-Tonyan, Gleb Aleshin, Anastasia Prikhodko, Daniil Kozlov, Evgeny Anokhin, Konstantin Babeshkin, Nikolay Titchenko, Anastasia Zubenko, Anna Shchukina, Yuri Fedorov, Stepan KalmykovThe application of nanoparticles is promising for the purposes of nuclear medicine due to the possibilities of using them as vectors and transporters of […]Sofia Khabirova
- Anti-Schistosomal Activity and ADMET Properties of 1,2,5-Oxadiazinane-Containing Compound Synthesized by Visible-Light Photoredox Catalysis September 25, 2024RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00599F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, […]Kennosuke Itoh
- Novel benzenesulfonamides containing dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity October 3, 2024
