RSC – RSC Med. Chem. latest articles- Structure and activity of conopressins: Insights into in silico oxytocin/V2 receptor interactions, anti-inflammatory potential, and behavioural studies. July 3, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00288E, Research ArticlePooja Dhurjad, Mohd Rabi Bazaz, Satyam Pati, Manoj P Dandekar, Chandraiah Godugu, Rajesh SontiConopressins are single disulfide conopeptides with a close sequence similarity to vasopressin and oxytocin, exhibiting grooming and scratching effects in rodents. Here, we have investigated the impact of stereochemistry on...The content of this RSS […]Pooja Dhurjad
- Unveiling the therapeutic potential of prenyl motif containing derivatives: A key structural fragment for designing antidepressant compounds July 2, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00473J, Review ArticleMd Jawaid Akhtar, Khalid Al Balushi, Bushara Al Sabahi, Shah Alam Khan, Afrah Al TamimiDepression is a complex mental disorder and successful treatment of this depressive disorder is challenging. The available medications often show limitations in terms of both safety and efficacy. The presence...The content of this […]Md Jawaid Akhtar
- Design of Chitosan-Coated CeO₂-Doped ZnCr LDO Nanocomposites for Optimized Azithromycin Delivery: A Kinetic and Mechanistic Perspective July 2, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00455A, Research ArticleMuhammad Babar Taj, Hina Afzal, Merfat Mohammed Alsabban, Walla Alelwani, Nadiyah S Alahamadi, Noushi Zaidi, Nouf A Babteen, Sana AfzalTraditional ways of formulating azithromycin are characterized by low oral bioavailability. Therefore, the development of new formulations to enhance drug bioavailability is crucial. The current study aims to […]Muhammad Babar Taj
- Synthesis and Investigation of Thieno[2,3-b]pyridines that Restore Activity of Topotecan July 2, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00509D, Research ArticleEmily K. Paulin, Natalie Haverkate, Petr Tomek, Jagdish K. Jaiswal, Emily Dobbs, Jumana Nahhas, Euphemia Leung, Xiang Gao, Lin-Kun An, Lisa I Pilkington, David BarkerChemoresistance poses a major challenge to the successful outcome of cancer chemotherapy by reducing or eliminating drug efficacy. Anti-cancer medicines causing DNA damage […]Emily K. Paulin
- Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach July 1, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00406C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Domiziana Masci, Michela Puxeddu, Claudia Colla, Antonio Coluccia, Martina Santelli, Pietro Sciò, Elena Mariotto, Giampietro Viola, Ernest Hamel, Rosa Lerose, Carmela Mazzoccoli, Romano Silvestri, Giuseppe La ReginaMicrowave-assisted synthesis of new pyrrole and […]Domiziana Masci
- Design, synthesis and characterization of novel pyridazin-3-one derivatives: in vitro vasorelaxant activity and in silico insights into eNOS modulation July 1, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00998C, Research ArticleMarian W. Aziz, Khaled O. Mohamed, Amira Karam Khalifa, Doaa B. Farag, Zeinab MahmoudTwo novel series of pyridazin-3-ones, designed as potential vasodilators, demonstrated superior aortic vasorelaxant activity, eNOS mRNA expression and nitric oxide up-levelling.To cite this article before page numbers are assigned, use the DOI form of […]Marian W. Aziz
- New melatonin biphenyl-linked scaffold targeting colorectal cancer: design, synthesis, biological, and ADME-Tox modelling studies July 1, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00410A, Research ArticleMariluz Silva-García, Angie Herrera-Ramírez, Wilson Cardona-Galeano, Andrés F. YepesA series of melatonin biphenyl-linked conjugates was designed and synthesized using a simple, cost-effective, and environmentally friendly method.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Mariluz Silva-García
- Exploration of hydrazine-based small molecules as metal chelators for KDM4 inhibition June 30, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00305E, Research ArticleAngus Saxton, Jayden Sterling, Michael Hamilton, Ramzi Abbassi, Adam McCluskey, Lenka Munoz, Jennifer R BakerHydrazines and related moieties are frequently employed in inhibitory compounds targeting iron-dependent dioxygenases such as the histone lysine demethylases (KDMs), which are promising targets in targeted epigenetic cancer therapies. Four...The content of this […]Angus Saxton
- Deciphering Allosterism of an Escherichia coli Hexuronate Metabolism Regulator: UxuR June 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00391A, Research ArticleBeatriz Almeida, Sean Aaron Wirt, Kristala Jones Prather, Alexandra CarvalhoD-glucuronate and D-galacturonate can be used by Escherichia coli as sole carbon sources. Their use is triggered by external environmental changes through the rearrangement of bacterial metabolic processes. Transcription factors...The content of this RSS Feed (c) The Royal […]Beatriz Almeida
- Computer-aided repositioning and functional in vitro assessment of novel PAD4 inhibitors June 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00395D, Research ArticleSofia Ruíz-Hernández, Fátima de Lourdes Ochoa-González, Julio E. Castañeda-Delgado, Othir Gidalti Galicia-Cruz, Ricardo Castillo-Velázquez, Mauricio Comas-García, Gildardo Rivera, Edgar E. Lara-RamírezPeptidyl arginine deiminase 4 (PAD4) is a protein that catalyzes both normal and abnormal citrullination of interacting protein partners, affecting gene regulation and being associated with diseases […]Sofia Ruíz-Hernández
- Structure and activity of conopressins: Insights into in silico oxytocin/V2 receptor interactions, anti-inflammatory potential, and behavioural studies. July 3, 2025
