RSC – RSC Med. Chem. latest articles- Ring-Opening Simplification of Thiazolyl-Pyrazoline-Triazole Hybrids: Synthesis, SAR and Antifolate Mechanism Against Leishmania major June 26, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00382F, Research ArticleEsraa A Abdelsalam, Wagdy M. Eldehna, Radwan El-Haggar, Sherif Hammad, Nicolas MASURIER, Tamer M Ibrahim, Kikuko Amagase, Sherry N Nasralla, Hatem A. Abdel-Aziz, Adnan BekhitLeishmaniasis, a neglected tropical disease with a severely limited and toxicity-prone therapeutic arsenal, urgently demands structurally innovative drug candidates. Capitalizing on the well-established […]Esraa A Abdelsalam
- Combining β2-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease June 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00250A, Research ArticleAlice Wang, Thomas Curel, Sylvie Claeysen, Valentin Travers-Lesage, Marie Elodie Hélène Cadot, Audrey Davis, Jana Sopkova de Oliveira Santos, Fabrice Modeste, Xavier Brazzolotto, Florian Nachon, Patrick Dallemagne, Marc Since, Christophe RochaisAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder for which the current treatments remain largely symptomatic. Pleiotropic […]Alice Wang
- From dual norepinephrine-dopamine reuptake inhibition to selective dopamine reuptake inhibitors: a case of aromatically substituted N,2-cyclopentylamines June 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00112B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Majlen A. Dilweg, Willem Jespers, Ameya S Kasture, Rongfang Liu, Tamara A. M. Mocking, Jelle G Van Der Ploeg, M M Baselier, Gerard Van Westen, Thomas Hummel, Sonja Sucic, Adriaan P. IJzerman, […]Majlen A. Dilweg
- Drug Repurposing of Fluvastatin as a DP2 Antagonist: An Ensemble Learning Strategy with In Vitro Cellular Functional Validation June 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00403B, Research ArticleGuoHui Wei, Zhuo Sun, Yuanxu Gao, Jia Heng, Wenyang Lu, Zixing ZouWe present a framework to repurpose FDA-approved drugs as DP2 antagonists for asthma, using a two-stage strategy. First, we train and evaluate eight models—five machine learning algorithms and three graph...The content of this RSS Feed (c) […]GuoHui Wei
- 1,8-Naphthalimide Heterocycles as Skeleton Structures Targeting Cancer: Insights into Synthesis, Bioactivity, SAR, and Future Directions June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00016A, Review ArticleJitendra Choudhary, Gurdeep Kaur, Iqubal Singh1,8-Naphthalimide-based heterocyclic compounds have emerged as an important class of anticancer agents owing to their strong DNA-intercalating ability, topoisomerase inhibition, and capacity to modulate multiple cellular pathways. This review aims...The content of this RSS Feed (c) The Royal Society of ChemistryJitendra Choudhary
- Synthesis and Bioevaluation of Substituted 2,11-dihydroimidazo[1′,5′:1,2]pyrido-[3,4-b]indoles as antiplasmodial and antiproliferative agents June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00085A, Research ArticleAdilakshmi Vutla, Akash Pandey, Amanullah Sayeed, Richa Shukla, Ashan Manhas, Niti Kumar, Sanjeev Meena, Dipak Datta, Sanjay BatraThe synthesis and bioevaluation of a new series of substituted 2,11-dihydroimidazo[1’,5’:1,2]pyrido-[3.4-b]indoles as antiplasmodial and antiproliferative agents are described. Several compounds (16aaf, 16abf, 16acf, 16adq, 16aeo, and 16afe ) exhibited significant...The […]Adilakshmi Vutla
- Discovery of Novel SIRT3 Inhibitors with MLLr Leukemia Inhibitory Potency June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00249H, Research ArticleShaopeng Chen, Xinyang Wei, Honggang Li, Jiangying Cao, lei zhangSIRT3 has emerged as a therapeutic target for the treatment of leukemia. Based on our previously identified lead compound, structural modification was performed in the current study. A total of...The content of this RSS Feed (c) The Royal […]Shaopeng Chen
- Discovery of Novel Indazole Derivatives with Antineuroinflammatory Activity June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00270F, Research ArticleQing qing Zhang, Xixi Hou, Xuanwei Zhang, Yimian Wang, Yaquan Cao, Lan Wang, Longfei MaoThis study focuses on the critical role of microglia-mediated neuroinflammation in various neurological disorders. Utilizing the indazole heterocycle-a scaffold known for its structural plasticity and multi-target potential-as the core structure,...The content of this […]Qing qing Zhang
- Exploring the Antimycobacterial Profile of N-Alkyl Imidazoles June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00418K, Research ArticleAlejandro I. Recio-Balsells, Gabriel Di Gresia, Marcelo Luciano Merli, Julia Alejandra Cricco, Hector R. Morbidoni, Guillermo R LabadieThe emergence of drug-resistant Mycobacterium tuberculosis strains and non-tuberculous mycobacteria (NTM) species such as Mycobacterium abscessus, highlights the urgent need for new chemotypes with broad-spectrum antimycobacterial activity. In this study,...The […]Alejandro I. Recio-Balsells
- Design and synthesis of N-3-substituted quinazolinone derivatives as anticancer agents targeting EGFR June 21, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01148E, Research ArticlePritam Maity, Poonam Yadav, Joydeep Chatterjee, Madhurendra Kumar Katiyar, Umashanker Navik, Raj KumarA series of new N-3-substituted quinazolinones targeting epidermal growth factor receptor (EGFR) was designed and synthesized for anticancer evaluation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Pritam Maity
- Ring-Opening Simplification of Thiazolyl-Pyrazoline-Triazole Hybrids: Synthesis, SAR and Antifolate Mechanism Against Leishmania major June 26, 2026
