RSC – RSC Med. Chem. latest articles- Synthetic routes towards antiviral agents from the Houttuynoid family: Structure-activity relationships and antiviral efficacy against herpes simplex virus type 1 May 17, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00158K, Review ArticleAdarsh Krishna T.P., Ajeesh Krishna T.P., Reshma Rajan, Laxman Kota, Prasobh K MohanNatural products remain a cornerstone of drug discovery, offering unparalleled chemical diversity and evolved biological specificity. Among these, the houttuynoids are unique class of flavonoid based metabolites isolated from Hottuynia...The content of this RSS Feed […]Adarsh Krishna T.P.
- Structure-activity relationship for calanthoside, a potential hairgrowth stimulant with an indole 2-S-,3-O-bis-glucoside structure. Part 1: Role of two glucoside moieties in promoting HFDPC proliferation May 14, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00273K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Riko Suzuki, Katsuki Takashima, Yoshiaki Mannse, Haruto Nishikawa, Mina Ashidate, Shinsuke Marumoto, Fumihiro Ishikawa, Toshio Morikawa, Genzoh TanabeThe development of new and effective drugs for treating androgenetic alopecia (AGA) remains challenging. Minoxidil […]Riko Suzuki
- Identification and structure-activity relationship analysis of minimal fusion inhibitors targeting measles virus F protein May 12, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00211K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kazuya Kobayashi, Yuki Yamaguchi, Mizuki Itahara, Kazushige Hirata, Keisuke Aoki, Naoya Iwamoto, Hironori Hayashi, Eiichi Kodama, Shinya OishiAlthough measles has been effectively controlled by vaccination, sporadic outbreaks still occur worldwide, highlighting the […]Kazuya Kobayashi
- Investigation of 2,3-diaryl-1,4-thiazolidin-4-ones as promising agents for reducing lipid accumulation in liver cell through AMPK activation: synthesis, in vitro, in silico and lipidomic studies May 10, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00226A, Research ArticleArnatchai Maiuthed, Nichawadee Sandech, Chieh Yang, Sucheewin Krobthong, Pattarawit Rukthong, Kittisak Sripha, Witcha Imaram, Chaiyawat Aonsri1,3-Thiazolidin-4-ones are versatile heterocyclic scaffolds with diverse biological activities, however efficient synthesis and identification of potent lipid-lowering derivatives remain challenging. Here, we report a rapid, scalable sealed-tube, acid-catalyzed three-component synthesis...The content of […]Arnatchai Maiuthed
- From scaffold to selectivity-medicinal insights of PRMT1 and PRMT4 inhibitors for epigenetic cancer therapy May 7, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00286B, Review ArticleKanchan Pal, Shivani Kasana, Balak Das Kurmi, Preeti PatelSAR and docking analysis indicate important structural determinants and binding interactions that promote Selective and Dual PRMT1 and PRMT4 inhibition, making them potentially useful as epigenetic targets in various cancer treatments.To cite this article before page numbers are assigned, […]Kanchan Pal
- Structure-Activity Relationships in a Series of Dihydrouracil-JQ1 Conjugates: Discovery of Highly Potent BRD4 Degraders May 6, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00259E, Research ArticleOleh Shyshlyk, Vladyslav Stadnichenko, Oleksandr Diachenko, Iryna Chernysh, Anna Beshtynarska, Diana Alieksieieva, Diana Khotinets, Oleksii Oleksiak, Dmytro Lesyk, Yelyzaveta Yeremenko, Angelina V. Biitseva, Petro Borysko, Volodymyr Yarmolchuk, Ganna M. Tolstanova, Oleksandr O. GrygorenkoA detailed study of structure-activity relationship (SAR) in a series of phenyl dihydrouracil (PDHU) derivatives […]Oleh Shyshlyk
- Ruthenium(II) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications May 5, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00154H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Martin R. GillThis review summarises the design of ruthenium(II) polypyridyl complexes (RPCs) as pharmacological DNA-targeting agents, linking binding mode, DDR pathway activation, and cancer cell fate.To cite this article before page numbers […]Martin R. Gill
- Design, synthesis, and biological evaluation of novel SN38-sulfonamide conjugates as Topo I/CA IX dual inhibitors inducing ferroptosis in colorectal cancer May 3, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00290K, Research ArticleXinyu Zhao, Anna Ye, Yujie Wang, Yeying Qiu, Shiyan Liu, Liyu Wei, Feng Qin, Ye Zhang, Ri-zhen HuangA series of novel SN38-sulfonamide conjugates were designed and synthesized as carbonic anhydrase IX (CA IX) and topoisomerase I (Topo I) dual inhibitors for colorectal cancer therapy. Structure-activity relationship analysis...The […]Xinyu Zhao
- Small-molecule therapeutics for diabetic retinopathy: from VEGFR inhibitors to emerging non-VEGF targets April 30, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00069J, Review ArticleYan Li, Wenfang Zhang, Yinliang Bai, Honghua ZhangSmall-molecule therapy for diabetic retinopathy is advancing from VEGFR inhibitors to non-VEGF targets, with success increasingly determined by ocular PK/PD optimization, route-specific delivery, and scaffold design rather than potency alone.To cite this article before page numbers are assigned, use the […]Yan Li
- Development of novel chalcone-based quinazoline derivatives as dual VEGFR-2 and EGFR inhibitors April 30, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00179C, Research ArticleZainab M. Elsayed, Haytham O. Tawfik, Loah R. Hemeda, Mohamed S. Nafie, Hadia Almahli, Rehan Monir, Ikhlas A. Sindi, Eslam B. Elkaeed, Mostafa M. Elbadawi, Mahmoud A. El Hassab, Wagdy M. EldehnaAs possible dual VEGFR-2/EGFR inhibitors, a new set of quinazoline-chalcone hybrid compounds (8a–h and 11a–h) was […]Zainab M. Elsayed
- Synthetic routes towards antiviral agents from the Houttuynoid family: Structure-activity relationships and antiviral efficacy against herpes simplex virus type 1 May 17, 2026
