RSC Medicinal Chemistry

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    • Design, synthesis and antibacterial evaluation of a novel class of tetrahydrobenzothiophene derivatives December 5, 2022
      RSC Med. Chem., 2022, Advance ArticleDOI: 10.1039/D2MD00373B, Research ArticleLin Lai, Jinhua Yang, Wanlin Sun, Xiaoyan Su, Jun Chen, Xinan Chen, Shuchen PeiIn this study, a new series of tetrahydrobenzothiophene derivatives have been designed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]
      Lin Lai
    • Pretargeted Imaging Beyond the Blood-Brain Barrier December 2, 2022
      RSC Med. Chem., 2022, Accepted ManuscriptDOI: 10.1039/D2MD00360K, Research Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vladimir Shalgunov, Sara Lopes van den Broek, Ida Vang Andersen, Rocio García-Vázquez, Nakul Ravi Raval, Mikael Palner, Yuki Mori, Gabriela Schäfer, Barbara Herrmann, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvänen, Matthias […]
      Vladimir Shalgunov
    • X-ray structure of human aldo-keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis December 1, 2022
      RSC Med. Chem., 2022, Accepted ManuscriptDOI: 10.1039/D2MD00387B, Research ArticleMaja A. Marinović, Sofija S. Bekić, Michael Kugler, Jiri Brynda, Jana Škerlová, Dušan Đ. Škorić, Pavlina Řezáčová, Edward T. Petri, Andjelka S. ĆelićAldo-keto reductase 1C3 (AKR1C3) catalyzes reduction of androstenedione to testosterone and reduces the effectiveness of chemotherapeutics. AKR1C3 is a target for treatment of breast and […]
      Maja A. Marinović
    • 6-Bromoindirubin-3’-oxime Derivatives are Highly Active Colistin Adjuvants against Klebsiella pneumoniae December 1, 2022
      RSC Med. Chem., 2022, Accepted ManuscriptDOI: 10.1039/D2MD00370H, Research ArticleHaoting Li, Anne Mattingly, Richard Smith, Roberta Worthington, Robert Ernst, Christian MelanderMultidrug resistant (MDR) bacterial infections have become increasingly common, leading clinicians to rely on last-resort antibiotics such as colistin. However, the utility of colistin is becoming increasingly compromised as a...The content of this RSS Feed (c) […]
      Haoting Li
    • Contributors to our Emerging Investigators collection December 1, 2022
      RSC Med. Chem., 2022, Advance ArticleDOI: 10.1039/D2MD90042D, ProfileRSC Medicinal Chemistry profiles the contributors to the ‘Emerging Investigators’ themed collection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
    • Introduction to the themed collection on fragment-based drug discovery December 1, 2022
      RSC Med. Chem., 2022, Advance ArticleDOI: 10.1039/D2MD90037H, EditorialDavid C. Rees, Anna K. H. Hirsch, Daniel A. ErlansonGuest editors David Rees, Anna Hirsch and Daniel Erlanson introduce the RSC Medicinal Chemistry themed collection on fragment-based drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]
      David C. Rees
    • Expanding the Structure-Activity Relationships of Alkynyl Diphenylurea Scaffold as Promising Antibacterial Agents November 30, 2022
      RSC Med. Chem., 2022, Accepted ManuscriptDOI: 10.1039/D2MD00351A, Research ArticleHanzada T. Nour El-Din, Mohamed M. Elsebaie, Nader S. Abutaleb, Ahmed M. Kotb, Ahmed S. Attia, Mohamed N. Seleem, Abdelrahman S. MayhoubWith the continuous and alarming threat of exhausting the current antimicrobial arsenals, efforts are urgently needed to develop new effective ones. In this work, the antibacterial […]
      Hanzada T. Nour El-Din
    • Therapeutic significance of molecular hybrids for breast cancer research and treatment November 29, 2022
      RSC Med. Chem., 2023, Advance ArticleDOI: 10.1039/D2MD00356B, Review Article Shagufta, Irshad AhmadThis review highlights the potential of a molecular hybridization approach in breast cancer treatment. It provides insights into the current progress in developing linked, merged, and fused hybrids as potential anti-breast cancer agents.To cite this article before page numbers are assigned, use the DOI […]
      Shagufta
    • Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores November 29, 2022
      RSC Med. Chem., 2022, Advance ArticleDOI: 10.1039/D2MD00253A, Research ArticleRebecca L. Whitehouse, Wesam S. Alwan, Olga V. Ilyichova, Ashley J. Taylor, Indu R. Chandrashekaran, Biswaranjan Mohanty, Bradley C. Doak, Martin J. ScanlonSmall molecule interaction hotpots were identified by screening small, low complexity fragments using X-ray crystallography. These hot spots include cryptic pockets and provide pharmacophore mapping […]
      Rebecca L. Whitehouse
    • The era of high-quality chemical probes November 28, 2022
      RSC Med. Chem., 2022, Advance ArticleDOI: 10.1039/D2MD00291D, Opinion Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marco P. Licciardello, Paul WorkmanA brief history of milestones leading to selection and use guidelines for high-quality chemical probes. We highlight their importance to study protein function and illustrate examples of recently developed […]
      Marco P. Licciardello