RSC – Mol. Omics latest articles- Thioridazine induces phospholipid accumulation and necroptosis in parental and tamoxifen-resistant breast cancer cells July 27, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00039D, Research ArticleChandrasekaran Mythri, Sachin B Jorvekar, Nirawane Suraj, Nethaji Pruthiviraj, Roshan M Borkar, Sudhagar SelvarajuThioridazine induces phospholipid accumulation and necroptosis in both parental and tamoxifen-resistant breast cancer cells, enhancing tamoxifen efficacy and showing promise as a repurposed treatment strategy.To cite this article before page numbers are assigned, use the […]Chandrasekaran Mythri
- Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry July 13, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00020C, Research ArticleAiswarya Suresh, Nikhil Pallaprolu, Aishwarya Dande, Harish Kumar Pogula, Vipan Kumar Parihar, Ramalingam PeramanProteomic profiling reveals storage temperature- and time-dependent degradation of tissue proteins, highlighting critical factors for sample preservation in mass spectrometry-based analyses.To cite this article before page numbers are assigned, use the DOI form of citation […]Aiswarya Suresh
- Understanding metabolic alterations in advanced stage chronic kidney disease patients by NMR-based metabolomics June 15, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00019J, Research ArticleAmrita Sahu, Upasna Gupta, Bikash Baishya, Dharmendra Singh Bhadauria, Neeraj SinhaIllustrate NMR-based metabolomics identifies distinct metabolic alterations and disrupted pathways in advanced-stage CKD, offering improved diagnostic insight beyond creatinine-based methods.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Amrita Sahu
- POMC-specific modulation of metabolic and immune pathways via melanocortin-3 receptor signaling June 10, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D4MO00248B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mariya Nezhyva, Friederike A. Sandbaumhüter, Per E. Andrén, Erik T. JanssonThis proteomic study provides a nuanced mechanistic understanding of the signaling processes upon agonist binding to the melanocortin-3 receptor (MC3R).To cite this article […]Mariya Nezhyva
- Advancing colorectal cancer research through lipidomics June 3, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00045A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pedro Santiago, Tânia Melo, Maria Barceló-Nicolau, Gwendolyn Barceló-Coblijn, Pedro Domingues, Rosário DominguesLipidomic profiling of CRC plasma and tissue reveals alterations in lipid species, including from phospholipids, sphingolipids, and glycerolipids.To cite this article before […]Pedro Santiago
- Integrated multi-omic analyses of bovine milk identify biomarkers of negative energy balance May 20, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D4MO00190G, Research ArticleA. Leduc, A. Rau, D. Laloë, S. Le Guillou, P. Martin, M. Gelé, J. Pires, Y. Faulconnier, C. Leroux, M. Boutinaud, F. Le ProvostAn integrative multi-omic study of bovine milk production and composition in two feed restriction trials to understand adaptations to negative energy balance and to develop […]A. Leduc
- Integrating N-glycan and CODEX imaging reveal cell-specific protein glycosylation in healthy human lung May 19, 2025Mol. Omics, 2025, 21,334-342DOI: 10.1039/D4MO00230J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dušan Veličković, Jeffrey Purkerson, Harsh Bhotika, Heidie Huyck, Geremy Clair, Gloria S. Pryhuber, Christopher AndertonIdentifying cell-specific glycan structures in human lungs is critical for understanding the chemistry and mechanisms that guide cell–cell and cell–matrix […]Dušan Veličković
- Lipid profiling: proving the geographical origin of strawberries (Fragaria × ananassa) using a non-targeted LC-IM-MS approach May 15, 2025Mol. Omics, 2025, 21,353-364DOI: 10.1039/D5MO00006H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Johannes Brockelt, Felix Schmauder, Marina Creydt, Markus FischerDifferentiation of strawberries from six different origins. Analysis of the lipid profile was performed using LC-IM-MS method. Geographical origin differentiation by identification of significant lipids.The content of […]Johannes Brockelt
- Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC May 11, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D4MO00154K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patricia Pascual-Vargas, Mar Arias-Garcia, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Chris BakalDOCK5 acts at focal adhesions in breast cells to establish positive feedback loops via CDC42 and RAC The stabilisation of polarity during […]Patricia Pascual-Vargas
- A multi-omics machine learning classifier for outgrowth of cow's milk allergy in children May 8, 2025Mol. Omics, 2025, 21,343-352DOI: 10.1039/D4MO00245H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Diana M. Hendrickx, Mariyana V. Savova, Pingping Zhu, Ran An, Sjef Boeren, Kelly Klomp, Sumanth K. Mutte, PRESTO study team, Harm Wopereis, Renate G. van der Molen, Amy C. Harms, Clara BelzerA multi-omics machine […]Diana M. Hendrickx
- Analysis of FAIMS for the study of affinity-purified protein complexes using the orbitrap ascend tribrid mass spectrometer May 6, 2025Mol. Omics, 2025, 21,303-314DOI: 10.1039/D5MO00038F, Research ArticlePratik Goswami, Joseph Cesare, Michaella J. Rekowski, Zachary Clark, Janet Thornton, Michael P. WashburnThe impact of the use of FAIMS on an affinity purification of protein complexes was studied and found that FAIMS significantly reduced specific contaminating ions.The content of this RSS Feed (c) The Royal Society of ChemistryPratik Goswami
- PPI network identifies interacting pathogenic signaling pathways in Candida albicans April 30, 2025Mol. Omics, 2025, 21,315-333DOI: 10.1039/D5MO00042D, Research ArticleDeepanjan Chattopadhyay, Sanjib Das, Paromita Saha Mondal, Tanushree Mondal, Subhasree Samanta, Amalesh Mondal, Achintya Mohan Goswami, Tanima SahaIdentification of interacting pathogenic signaling pathways in Candida albicans through PPI network studies.The content of this RSS Feed (c) The Royal Society of ChemistryDeepanjan Chattopadhyay
- Transcriptome and proteome analyses reveal the virulence of the Vibrio alginolyticus effector gene vopR April 24, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00010F, Research ArticleFan Da, Shuanghu Cai, Liangliang Xu, Shixi Chen, Bin Li, Min TaoVibrio alginolyticus is an opportunistic infectious pathogen, and its pathogenicity is related to various virulence factors, with the type III secretion system (T3SS) being one of the important systems for secreting virulence factors.To cite this article before […]Fan Da
- Characterizing metabolic dysregulation in early-stage chronic kidney disease for diagnostic insights April 24, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00018A, Research ArticleUpasna Gupta, Amrita Sahu, Dharmendra Singh Bhadauria, Bikash Baishya, Neeraj SinhaUnderstanding these metabolic and pathophysiological processes and discovering relevant biomarkers enables early identification, individualized treatment plans, and the possibility of slowing down or even reversing the progression of CKD.To cite this article before page numbers are assigned, use […]Upasna Gupta
- Proteomic and metabolomic dissection of the BRAF V600E mutation-induced cellular state transition in lung epithelial cells April 22, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D4MO00249K, Research ArticleFengting Liu, Fan Yang, Hailin Xiong, Jingnan Huang, Zhenhui Huang, Jingying Song, Xinyi Liu, Hongchao Zhou, Jing Xu, Jimin Yuan, Lin Jia, Lingyun DaiThis study established a BRAF V600E knock-in BEAS-2B cell model that allows us to systematically dissect the underlying molecular events involved in the cellular state […]Fengting Liu
- Retraction: Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells April 21, 2025Mol. Omics, 2025, 21,250-250DOI: 10.1039/D5MO90007G, Retraction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yincong Chen, Haibiao Xie, Yifan Zou, Xiulan Lai, Lian Ma, Yuchen Liu, Jianfa LiThe content of this RSS Feed (c) The Royal Society of ChemistryYincong Chen
- Human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during titanium dioxide nanoparticle (TiO2-NP) exposure April 8, 2025Mol. Omics, 2025, 21,282-302DOI: 10.1039/D4MO00205A, Research ArticleGobichettipalayam Balasubramaniam Maadurshni, Balamurali Mahalakshmi, Manikandan Nagarajan, Jeganathan ManivannanThe increasing exposure to nanoparticles raises a concern over their toxicity.The content of this RSS Feed (c) The Royal Society of ChemistryGobichettipalayam Balasubramaniam Maadurshni
- Transcriptome profiling of serum exosomes by RNA-Seq reveals lipid metabolic changes as a potential biomarker for evaluation of roxadustat treatment of chronic kidney diseases March 17, 2025Mol. Omics, 2025, 21,240-249DOI: 10.1039/D4MO00025K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ru Zhou, YaXuan Zhen, Hualin Ma, Zhen Wang, LiXia Liu, Xinzhou Zhang, Baochun GuoRoxadustat alters serum exosomal mRNA–lncRNA profiles in CKD. These findings highlight a novel regulatory axis linked to lipid metabolism, enhancing treatment […]Ru Zhou
- Lipidomics reveals cell specific changes during pluripotent differentiation to neural and mesodermal lineages March 13, 2025Mol. Omics, 2025, 21,259-269DOI: 10.1039/D4MO00261J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Melanie T. Odenkirk, Haley C. Jostes, Kevin R. Francis, Erin S. BakerLipidomic analyses of induced pluripotent stem cells at critical stages of differentiation toward neural or mesodermal fates illustrate unique species and class-based fluctuations.The […]Melanie T. Odenkirk
- Exon–intron boundary detection made easy by physicochemical properties of DNA March 11, 2025Mol. Omics, 2025, 21,226-239DOI: 10.1039/D4MO00241E, Research ArticleDinesh Sharma, Danish Aslam, Kopal Sharma, Aditya Mittal, B. JayaramChemEXIN is an advanced tool for the accurate prediction of exon–intron boundaries in eukaryotic genomes. It utilizes biophysical features and deep learning methods for robust performance, making it a versatile tool for exon–intron prediction.The content of this RSS Feed (c) […]Dinesh Sharma
- Thioridazine induces phospholipid accumulation and necroptosis in parental and tamoxifen-resistant breast cancer cells July 27, 2025
