RSC – Mol. Omics latest articles- MALDI mass spectrometry imaging in plant and food lipidomics: advances, challenges, and future perspectives September 25, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00116A, Review ArticleG. Ventura, M. Bianco, I. Losito, T. R. I. Cataldi, C. D. CalvanoMALDI MSI enables high-resolution spatial lipid analysis in plants and food. This review covers current methods, challenges, and emerging technologies shaping the future of plant and food lipidomics research.To cite this article before page numbers are […]G. Ventura
- Prunus mongolica oil attenuates hepatic fibrosis via a lncRNA-mediated ceRNA network targeting dual PGC-1α/PPARγ and TGF-β/Smad3 pathways September 22, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00083A, Research ArticleYiJie Hou, HongBing Zhou, XiaoGang Li, JiaXing Gao, Hong Chang, Jia Wang, YingChun Bai, ShuYuan Jiang, ShuFang Niu, WanFu Bai, SongLi ShiThis study systematically investigated the antifibrotic mechanism of Prunus mongolica oil through an integrated approach combining pharmacodynamics, transcriptomics, and molecular biology in CCl4-induced Sprague–Dawley rat models.To cite […]YiJie Hou
- Network-driven identification of indisulam neo-substrates for targeted protein degradation September 22, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00053J, Research ArticleAndrew F. Jarnuczak, Orli Yogev, Angelo Andres, Stephanie K. Ashenden, Cheng Ye, Fiona Pachl, Andrew Zhang, Maria Emanuela Cuomo, Meizhong JinMolecular glue neo-substrate identification via proteomics profiling and network analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Andrew F. Jarnuczak
- Deep learning methods and applications in single-cell multimodal data integration September 9, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00062A, Review ArticleFranklin Vinny Medina Nunes, Luiza Marques Prates Behrens, Rafael Diogo Weimer, Gabriela Flores Gonçalves, Guilherme da Silva Fernandes, Márcio DornThis review examines cutting-edge deep learning methods for integrating single-cell multimodal data, highlighting key tools and their applications in harmonizing various omics layers and improving downstream biological analyses.To cite […]Franklin Vinny Medina Nunes
- Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in caveolin-1 null mice September 9, 2025Mol. Omics, 2025, 21,512-523DOI: 10.1039/D5MO00059A, Research ArticleShankar P. Poudel, Maliha Islam, Thomas B. McFadden, Susanta K. BehuraMice lacking caveolin-1 (Cav1), a major protein of the lipid raft of plasma membrane, show deregulated metabolism of the mammary gland and an abnormal fetoplacental communication during pregnancy.The content of this RSS Feed (c) The Royal Society of ChemistryShankar P. Poudel
- Differentially regulated saliva proteome and metabolome: a way forward for risk-assessment of oral cancer among tobacco abusers September 2, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00058K, Research ArticleBolaji Fatai Oyeyemi, Shruti Dabral, Amit Paramaraj, Sandhya Srinivasan, Gagan Deep Jhingan, Dhiraj Kumar, Chintamani, Abhinav Kumar, Néel Sarovar BhaveshOral cancer (OC) is a malignant tumour with high morbidity and mortality.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Bolaji Fatai Oyeyemi
- Thioridazine induces phospholipid accumulation and necroptosis in parental and tamoxifen-resistant breast cancer cells July 27, 2025Mol. Omics, 2025, 21,496-511DOI: 10.1039/D5MO00039D, Research ArticleChandrasekaran Mythri, Sachin B Jorvekar, Nirawane Suraj, Nethaji Pruthiviraj, Roshan M Borkar, Sudhagar SelvarajuThioridazine induces phospholipid accumulation and necroptosis in both parental and tamoxifen-resistant breast cancer cells, enhancing tamoxifen efficacy and showing promise as a repurposed treatment strategy.The content of this RSS Feed (c) The Royal Society of ChemistryChandrasekaran Mythri
- Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry July 13, 2025Mol. Omics, 2025, 21,479-495DOI: 10.1039/D5MO00020C, Research ArticleAiswarya Suresh, Nikhil Pallaprolu, Aishwarya Dande, Harish Kumar Pogula, Vipan Kumar Parihar, Ramalingam PeramanProteomic profiling reveals storage temperature- and time-dependent degradation of tissue proteins, highlighting critical factors for sample preservation in mass spectrometry-based analyses.The content of this RSS Feed (c) The Royal Society of ChemistryAiswarya Suresh
- Understanding metabolic alterations in advanced stage chronic kidney disease patients by NMR-based metabolomics June 15, 2025Mol. Omics, 2025, 21,464-478DOI: 10.1039/D5MO00019J, Research ArticleAmrita Sahu, Upasna Gupta, Bikash Baishya, Dharmendra Singh Bhadauria, Neeraj SinhaIllustrate NMR-based metabolomics identifies distinct metabolic alterations and disrupted pathways in advanced-stage CKD, offering improved diagnostic insight beyond creatinine-based methods.The content of this RSS Feed (c) The Royal Society of ChemistryAmrita Sahu
- POMC-specific modulation of metabolic and immune pathways via melanocortin-3 receptor signaling June 10, 2025Mol. Omics, 2025, 21,456-463DOI: 10.1039/D4MO00248B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mariya Nezhyva, Friederike A. Sandbaumhüter, Per E. Andrén, Erik T. JanssonThis proteomic study provides a nuanced mechanistic understanding of the signaling processes upon agonist binding to the melanocortin-3 receptor (MC3R).The content of this RSS […]Mariya Nezhyva
- Advancing colorectal cancer research through lipidomics June 3, 2025Mol. Omics, 2025, 21,373-389DOI: 10.1039/D5MO00045A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pedro Santiago, Tânia Melo, Maria Barceló-Nicolau, Gwendolyn Barceló-Coblijn, Pedro Domingues, Rosário DominguesLipidomic profiling of CRC plasma and tissue reveals alterations in lipid species, including from phospholipids, sphingolipids, and glycerolipids.The content of this RSS Feed […]Pedro Santiago
- Integrated multi-omic analyses of bovine milk identify biomarkers of negative energy balance May 20, 2025Mol. Omics, 2025, 21,433-445DOI: 10.1039/D4MO00190G, Research ArticleA. Leduc, A. Rau, D. Laloë, S. Le Guillou, P. Martin, M. Gelé, J. Pires, Y. Faulconnier, C. Leroux, M. Boutinaud, F. Le ProvostAn integrative multi-omic study of bovine milk production and composition in two feed restriction trials to understand adaptations to negative energy balance and to develop non-invasive […]A. Leduc
- Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC May 11, 2025Mol. Omics, 2025, 21,390-421DOI: 10.1039/D4MO00154K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patricia Pascual-Vargas, Mar Arias-Garcia, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Chris BakalDOCK5 acts at focal adhesions in breast cells to establish positive feedback loops via CDC42 and RAC The stabilisation of polarity during migration […]Patricia Pascual-Vargas
- Transcriptome and proteome analyses reveal the virulence of the Vibrio alginolyticus effector gene vopR April 24, 2025Mol. Omics, 2025, 21,446-455DOI: 10.1039/D5MO00010F, Research ArticleFan Da, Shuanghu Cai, Liangliang Xu, Shixi Chen, Bin Li, Min TaoVibrio alginolyticus is an opportunistic infectious pathogen, and its pathogenicity is related to various virulence factors, with the type III secretion system (T3SS) being one of the important systems for secreting virulence factors.The content of this RSS Feed […]Fan Da
- Proteomic and metabolomic dissection of the BRAF V600E mutation-induced cellular state transition in lung epithelial cells April 22, 2025Mol. Omics, 2025, 21,422-432DOI: 10.1039/D4MO00249K, Research ArticleFengting Liu, Fan Yang, Hailin Xiong, Jingnan Huang, Zhenhui Huang, Jingying Song, Xinyi Liu, Hongchao Zhou, Jing Xu, Jimin Yuan, Lin Jia, Lingyun DaiThis study established a BRAF V600E knock-in BEAS-2B cell model that allows us to systematically dissect the underlying molecular events involved in the cellular state transitions […]Fengting Liu
- MALDI mass spectrometry imaging in plant and food lipidomics: advances, challenges, and future perspectives September 25, 2025
