RSC – Nat. Prod. Rep. latest articles- Emerging technologies for the discovery of biosynthetic genes in plants June 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00011H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anne Jaczkowski, Arne Bültemeier, Benedikt Seligmann, Boas Pucker, Jakob FrankeCompared to microbial natural product research, elucidating biosynthetic pathways in plants requires distinct methodological approaches. This review describes emerging technologies for discovering biosynthetic […]Anne Jaczkowski
- Ecological context for bacterial natural products discovery June 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00018E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonathan Parra, Marla I. Macias-Contreras, Dulce G. Guillén Matus, Katherine R. DuncanThis review highlights recent studies and considerations towards ecological approaches to natural product discovery.To cite this article before page numbers are […]Jonathan Parra
- Microbial biotransformation of plant-derived metabolites: mechanisms, pathways, and multi-omics integration June 9, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00039H, Review ArticleYoungse Oh, Jaeyoun Lee, Soohyun Um, Seung Hyun KimThis review presents a reaction-class atlas of microbial biotransformations of plant-derived metabolites and highlights how enzymatic mechanisms and multi-omics approaches reveal metabolic diversity in complex microbial communities.To cite this article before page numbers are assigned, use the DOI form […]Youngse Oh
- Hot off the Press June 9, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP90022D, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as humupulusone A from Humulus lupulus.To cite this article before page numbers are assigned, use the DOI […]Robert A. Hill
- Rare functional groups and unique scaffolds in Streptomyces natural products June 7, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00012F, Review ArticleSanyuan Shi, Xuerui Jin, Gaoli Wang, Xuewei Hao, Jing Xie, Liujie Huo, Yunzi LuoThis review highlights Streptomyces natural products with rare functional groups, unique scaffolds, and atypical modifications, examining the enzymatic mechanisms to link biosynthetic diversity with synthetic biology applications.To cite this article before page numbers are […]Sanyuan Shi
- Advances in the discovery and functional analysis of Anti-infective and immunomodulatory natural products from host-associated microbiomes June 4, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00003G, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Götze, Christine BeemelmannsThis review highlights discoveries from 2018 to 2025 of microbiome-derived natural products with anti-infective and immunomodulatory actvities, and urges to more targeted OMICs approaches to fully harness the encoded […]Sebastian Götze
- Natural products with atypical atoms: unveiling structures, biosynthetic pathways, and bioactivities June 3, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00083A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yeo Jin Lee, Hyeon-Jeong Hwang, Jungro Lee, Hyeon Seung Park, Juwan Son, Mohammad Seyedsayamdost, Munhyung Bae, Seoung Rak Lee, Yun KwonRare elements in natural products unlock new chemical space, biosynthetic logic, and […]Yeo Jin Lee
- Inverse stable isotopic labeling for natural product characterization and discovery June 2, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00014B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jose Miguel D. Robes, Aaron W. PuriThis review highlights applications of inverse stable isotope labeling in natural product research, including biosynthesis, structural elucidation, and discovery, spanning 2005 to 2026.To cite this article […]Jose Miguel D. Robes
- Unlocking hidden enzymatic chemistry in natural product biosynthesis June 1, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00034G, HighlightMicah Harris, Asher Paul, Edward KalkreuterThis highlight reviews many of the existing and emerging strategies for prioritizing and accessing novel enzymology from microbial biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Micah Harris
- Synthetic biology as a game-changer for endangered medicinal orchids: biosynthesis, engineering and conservation June 1, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00027D, Review ArticleLin Qiu, Xianghui Chen, Zhan Luo, Min Jiang, Hu Chen, Biyu Hou, Haizheng Yu, Ning Li, Lei ZhangSynthetic biology acts as a game-changer for endangered medicinal orchids, enabling a transition from resource scarcity and extraction inefficiency to sustainable conservation through pathway decoding, chassis engineering and green biomanufacturing.To […]Lin Qiu
- From gene discovery to synthetic biology: recent advances in the biosynthesis of oleanane-type pentacyclic triterpenoids May 25, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00013D, Review ArticleIsmail Abdelsamad, Mohamed Abdulbagi, Jingya Wang, Zheyong Xue, Xu LuThis review discusses recent progress in biosynthetic enzymes, regulatory networks, and synthetic biology strategies for oleanane-type triterpenoids, including AI-driven predictive optimization for sustainable production.To cite this article before page numbers are assigned, use the DOI form of citation […]Ismail Abdelsamad
- Charting the path for L-tyrosine derivatives: from engineering strategies to microbial cell factories March 24, 2026Nat. Prod. Rep., 2026, 43,1026-1062DOI: 10.1039/D5NP00091B, Review ArticleLi Zhou, Xulei Shi, Hui Jiang, Yuanyuan Xia, Haiquan Yang, Wei Shen, Yu Cao, Xianzhong ChenReview highlights cutting-edge advances in producing L-tyrosine derivatives via tyrosol, p-coumaric acid, and L-DOPA nodes in E. coli and yeast.The content of this RSS Feed (c) The Royal Society of ChemistryLi Zhou
- Highlights of cyanobacterial metabolites reported between 2021–2024 March 16, 2026Nat. Prod. Rep., 2026, 43,1008-1025DOI: 10.1039/D5NP00076A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Simon Sieber, Elisabeth M.-L. JanssenThis review provides an overview of newly identified cyanobacterial metabolites from 2021 to 2024. The discovery of specific natural products is discussed.The content of this RSS Feed (c) The […]Simon Sieber
- Decision making by modular polyketide synthases and implications for genetic engineering March 13, 2026Nat. Prod. Rep., 2026, 43,961-1007DOI: 10.1039/D6NP00010J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kira J. WeissmanThis review details the many choices underlying faithful biosynthesis of complex polyketides in bacteria, and highlights the implications for genetic engineering aiming to generate novel derivatives.The content of this RSS Feed […]Kira J. Weissman
- Quinic acid as a chiron in total synthesis March 3, 2026Nat. Prod. Rep., 2026, 43,932-960DOI: 10.1039/D5NP00087D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manuel J. Verganista, Iago C. Vogel, Nuno R. CandeiasQuinic acid is a versatile chiral building block in asymmetric synthesis, enabling diverse natural products and bioactive compounds. This review highlights four decades of strategies, […]Manuel J. Verganista
- Microbial production of C7–C9 aromatic building blocks for the production of natural products February 23, 2026Nat. Prod. Rep., 2026, 43,897-931DOI: 10.1039/D5NP00068H, Review ArticleQiaoqiao Dai, Jiaqi Xu, Jing Wu, Xiaomin Li, Cong Gao, Guipeng Hu, Liming LiuThis review surveys representative C7–C9 aromatic compounds, outlining their microbial biosynthetic pathways, key metabolic challenges, and recent advances in metabolic engineering for their microbial production.The content of this RSS Feed (c) The Royal Society of […]Qiaoqiao Dai
- Isolation and synthesis of bisabosquals, fungal triprenyl phenol meroterpenoids with a densely functionalised bisabolane core February 2, 2026Nat. Prod. Rep., 2026, 43,803-812DOI: 10.1039/D5NP00085H, HighlightJames P. Shephard, David W. LuptonBisabosquals and seco-bisabosquals are unusual fungal meroterpenoids with a densely functionalised bisabolane core. Herein, we highlight their isolation, biosynthesis and bioactivities along with studies on their total syntheses.The content of this RSS Feed (c) The Royal Society of ChemistryJames P. Shephard
- Natural product inspired antibiotics approved for human use – 1943 to 2025 December 11, 2025Nat. Prod. Rep., 2026, 43,813-896DOI: 10.1039/D5NP00067J, Review ArticleMark S. Butler, Robert J. CaponThis review captures the legacy of natural products in shaping modern infection control and highlights their potential for delivering the next generation of life-saving antibiotics.The content of this RSS Feed (c) The Royal Society of ChemistryMark S. Butler
- AI and mechanistic modeling for characterizing biosynthetic pathways of natural products November 7, 2025Nat. Prod. Rep., 2026, 43,787-802DOI: 10.1039/D5NP00059A, HighlightByung Tae Lee, Byeongsub Lee, Joon Young Kwon, Tilmann Weber, Hyun Uk KimIntegrating AI-driven and mechanistic modeling accelerates the discovery and engineering of natural product biosynthetic pathways.The content of this RSS Feed (c) The Royal Society of ChemistryByung Tae Lee
- Emerging technologies for the discovery of biosynthetic genes in plants June 10, 2026
