RSC – Org. Biomol. Chem. latest articles- Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application in drug modification September 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01389E, CommunicationSheng Yu, Yangjian Cheng, Changduo Pan, Jin-Tao YuA photocatalytic radical cascade cyclization of N-acryloylhydrazides with α-bromoketones was developed. A series of 4-(3-oxo-3-phenylpropyl)-1H-pyrazol-5(4H)-ones were formed in moderate to good yields.α-Bromo difluoroacetamides and 2-bromoacetonitrile were also suitable reaction partners....The content of this RSS Feed (c) The Royal Society of ChemistrySheng Yu
- Annulative coupling of dicoumarols and β-ketosulfoxonium ylides: Access to dihydrofuran-fused coumarins September 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01305D, PaperRahul Kumar Saini , Satyendra Kumar PandeyA reagent-and catalyst-free one-pot cascade strategy has been developed for the efficient synthesis of dihydrofuran-fused coumarins (DHFCs) from β-ketosulfoxonium ylides and dicoumarol derivatives. This eco-friendly method involves sequential intermolecular 1,4-conjugate...The content of this RSS Feed (c) The Royal Society of ChemistryRahul Kumar Saini
- Eco-efficient C–H alkynylation of indoles via mechanochemical ruthenium catalysis September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01198A, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rajaram Maayuri, Vikash Kumar, Sourav Maiti, Parthasarathy GandeepanMechanochemical ruthenium(II)-catalyzed C2-alkynylation of indoles offers a sustainable alternative to solution-phase methods with improved green metrics and broad synthetic scope.To cite this article before page numbers […]Rajaram Maayuri
- Anthracene-Isatoic Anhydride Hybrids for Bioconjugation: Chromophores with Nucleophile Dependent Response September 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01187F, PaperChloe Fordyce, Callum Robinson, Gabriel RudebuschThe use of activated esters to label nucleophilic sites in biomolecules is a well established platform in bioconjugate chemistry. Here, we report the synthesis of a pair of anthracene-isatoic anhydride...The content of this RSS Feed (c) The Royal Society of ChemistryChloe Fordyce
- Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01223F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Katarzyna Jastrzębska, Agata Szymańska, Tomasz Pawlak, Rafał DolotWe demonstrate the oxathiaphospholane-based synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs with confirmed stereochemistry and enzymatic stability, highlighting their potential for therapeutic applications.To cite this […]Katarzyna Jastrzębska
- Advances in the direct transformations of propargylic alcohols and sulphur-containing reagents September 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01220A, Review ArticleJiayi Chao, Rumeng Yang, Jiarui Huang, Xi Chen, Xian-Rong Song, Qiang XiaoSulphur-containing compounds are regarded as an important class of organic compounds that are widely applied in pharmaceuticals, agriculture, material sciences, natural products, and organic synthesis. Consequently, the development of synthetic...The content of this RSS Feed (c) […]Jiayi Chao
- DBU-Catalysed Cascade Nucleophilic Addition/Cyclization to Access 7-Nitro (Ester) Imidazo[1,2-a]pyridin-8-amines September 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01228G, PaperDevendra Nagineni, Naga Pranathi Abburi Naga Pranathi, Prakesh Suman Behra, Manasa Konderpu, Sridhar Balasubramanian, Srinivas KantevariIn this report, we present the first examples of DBU-catalysed cascade reactions involving 1-(3-alkynyl)-1H-imidazole-2-carbonitriles and CH-acids such as nitromethane and malonates. This solvent-free transformation occurs through the nucleophilic CH-acid addition...The content of this […]Devendra Nagineni
- Stereoselective synthesis of 3,3ʹ-spirooxindoles with higher order heterocycles September 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01278C, Review ArticleRT Starthring, Biplob Borah, L. Raju ChowhanDespite the current advancement accomplished in the asymmetric construction of spirocyclic oxindoles fused with three-to six-membered heterocycles, accessing enantioenriched spirooxindoles fused with larger heterocycles has been far less developed. Inspired...The content of this RSS Feed (c) The Royal Society of ChemistryRT Starthring
- Electrochemical late-stage N-sulfonylation of in-situ generated indole-based hydrazones and their antimicrobial evaluation September 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01107H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Parmjeet Kaur, Anuj Kumar, Tashi Palmo, KULJIT SINGH, Vikas TyagiHerein, we report a novel metal-free electrochemical strategy for the late-stage and regioselective N-sulfonylation of in-situ generated indole-based hydrazones using readily available sodium sulfinates. […]Parmjeet Kaur
- A Synthesis of 1β-Hydroxytestosterone, a Metabolite of Xenobiotic Human Cytochrome P450 Enzymes, Beginning with a Borylation of Boldione September 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01218J, PaperAnna I. Elizondo, Kevin D. McCarty, Hadi Arman, F. Peter Guengerich, Francis YoshimotoXenobiotic cytochrome P450 enzymes have been shown to hydroxylate testosterone at various positions in the steroid backbone, including C1 to produce 1β-hydroxytestosterone. Despite the potential application to study the biochemistry...The content of this RSS Feed (c) […]Anna I. Elizondo
- Recent Advances in Photoinduced Amidyl Radical-Mediated Remote C(sp3)–H Activation via 1,5-Hydrogen Atom Transfer September 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01197C, Review ArticleMin Liao, Yuanyuan Li, Meiling Ye, Chunjuan LiuC-H bonds are widely present in organic molecules and play a crucial role in chemical diversification. Among them, the functionalization of unactivated C(sp³)-H bonds is highly challenging. The 1,5-hydrogen atom...The content of this RSS Feed (c) The Royal Society of […]Min Liao
- The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones September 7, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01290B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bimod Thapa, Farideh Javid, Cameron Lawson, Mark Soesanto, Karl HemmingAminocyclopropenones undergo a stereospecific and regiospecific catalyst-free, thermal ring-opening reaction with alcohols to yield β-enamino esters (also known as vinylogous carbamates or aminoacrylates).To cite […]Bimod Thapa
- New carborane–BODIPY conjugates: synthesis, photochemical properties and tumor cell photodamage September 4, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01238D, PaperAndrei V. Zaitsev, Alina A. Markova, Minh Tuan Nguyen, Anton V. Makarenkov, Anna V. Shibaeva, Ivan D. Burtsev, Anton E. Egorov, Alexander F. Smol'yakov, Elena G. Kononova, Vladimir A. Kuzmin, Alexander A. Shtil, Valentina A. Ol'shevskayaNew carborane-BODIPY conjugates were synthesized via nucleophilic SN2 substitution or CuAAC click reactions. […]Andrei V. Zaitsev
- Visible-light-induced three-component alkylation of 1,3,4-oxadiazoles via 1,5-hydrogen atom transfer (1,5-HAT) September 4, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01243K, CommunicationZhongzhen Yang, Xingqin Tian, Yafei Zhu, Tianle Huang, Yong Wu, Guanghui LvWe developed a visible-light-induced three-component alkylation of 1,3,4-oxadiazoles via 1,5-hydrogen atom transfer. This method features mild reaction conditions, broad substrate scope, and good functional group compatibility.To cite this article before page numbers are assigned, use the DOI […]Zhongzhen Yang
- Mukaiyama–Michael reaction: enantioselective strategies and applications in total synthesis September 3, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01134E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Quinlyn Waulters-Kline, Chinnakuzhanthai Gangadurai, Sagar S. Thorat, Anna C. Renner, Mukund P. SibiThis review details enantioselective methods for the Mukaiyama–Michael reaction, a powerful approach for the formation of C–C bonds and hindered […]Quinlyn Waulters-Kline
- Nickel-Catalyzed Reductive Cross-Coupling of Aziridines and Benzyl Chlorides September 2, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01299F, CommunicationJie Wan, Sen-Lin Wang, Cheng-Ke Liu, Yu-Lu Chen, Hai-Liang Ni, Peng Cao, Ping Hu, Bi-Qin Wang, Bin ChenA nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach to obtain β-benzyl-substituted arylethylamines bearing...The content […]Jie Wan
- From BN-Dewar Benzene to BN-Benzvalene: A Computational Exploration of Photoisomerization Mechanisms September 2, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01156F, PaperCristian Guerra, Yeray A. Rodriguez-Nuñez, Efrain Polo, Leandro Ayarde-Henríquez, Diana Ramirez, Adolfo Ensuncho MuñozThis study explores the photochemical conversion of BN-Dewar benzene into BN-benzvalene derivatives, offering a strategic route to heteroatom containing valence isomers with distinctive electronic properties. Using time-dependent density functional theory...The content of this RSS Feed […]Cristian Guerra
- Photochemical carbosulfonylative cross-coupling of alkenes September 2, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01229E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vanessa E. Becker, Mandapati Bhargava Reddy, Eoghan M. McGarriglePolarity mismatched carbosulfonylative cross-coupling of alkenes gives highly functionalized sp3 sulfone products using an Ir photocatalyst and 456 nm blue LEDs.To cite this article before […]Vanessa E. Becker
- RuII-phosphine catalysed direct synthesis of benzimidazoles via acceptorless dehydrogenative coupling of alcohols with aromatic diamines September 2, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01280E, PaperAnkit Pandey, Maravanji Shivaramaiah BalakrishnaWe report the synthesis and characterization of a RuII complexes containing amide-based phosphine ligands [o-Ph2P(C6H4)C(O)N(H)C6H4(o-OR)] (L1 R = Me; L2 R = Et; L3 R = iPr). Treatment of ligands...The content of this RSS Feed (c) The Royal Society of ChemistryAnkit Pandey
- Effect of a ligand on the asymmetric hydrogenation of cyclic N-sulfonyl amines catalyzed by nickel September 1, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01087J, PaperHeming Dong, Fuli Yan, Zhifeng Ma, Baomin FanDFT explores the effect of a ligand on the asymmetric hydrogenation of cyclic N-sulfonyl amines catalyzed by nickel with various oxidation states. The major S-configured product is attributed to the electrostatic interaction and CH–π interaction.To cite this article before page numbers […]Heming Dong
- Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application in drug modification September 9, 2025
