RSC – Org. Biomol. Chem. latest articles- Iodine-Promoted Oxidative Cross-Coupling for the Synthesis of (E)-2-(3-Oxo-3-Phenylprop-1-en-1-yl)-3-Phenylquinazolin-4(3H)-one via C-H Activation: Development of Synthetic TLX Agonists July 10, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00672D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lingaiah Maram, Puhan Zhao, Thomas Koelblen, Lamees Hegazy, Thomas P. Burris, Bahaa ElgendyWe report the development of an efficient iodine-promoted oxidative cross-coupling reaction for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one derivatives. This novel methodology facilitates […]Lingaiah Maram
- Design of Pyrrolo[2,3-d]Pyrimidine-Endoperoxide Hybrids as First-in-Class Dual Degraders of Cyclin D1/3 and CDK4/6 with Potent Antiproliferative Effects July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00501A, PaperZhen Cui, Yuanli Yang, Changqi Wang, Jiayi Zhu, Haowei Jiao, Lu Wang, Silong Zhang, Huan He, Hang ZhongThe hyperactive heterodimer of Cyclin D-CDK4/6 plays a pivotal role in regulating the cell cycle of breast cancer cells, and several CDK4/6 inhibitors have been developed and marketed for breast...The content […]Zhen Cui
- Ball-Milling-Mediated Remote Asymmetric Reductive Coupling in Air July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00829H, CommunicationHao Lei, Yufang Yang, Jiajia Sun, Shu Fan, Xiaofeng Wei, Siyuan Wang, haishu lin, yan kangDicarbofunctionalization reactions of unsaturated systems via radical relayed strategies are crucial for the efficient synthesis of complex molecules. Mechanochemical synthesis offers a compelling alternative to traditional solvent-based methods, providing advantages...The content of this […]Hao Lei
- Lithium tert-Butoxide-Mediated Efficient Transesterification of N-Hydroxyphthalimide Esters toward Oxime Functionalization July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00851D, PaperJiangfei Chen, Yi-Lin Qu, Hongyan Hao, Cheng Yao, Yu-Rou Wang, Dayun Huang, Chengshu Dai, Sheng-Rong GuoWe report an efficient lithium tert-butoxide (LiOtBu)-mediated transesterification of N-hydroxyphthalimide (NHPI) esters with oximes to afford oxime esters under mild conditions. This transition-metal-free method exhibits high chemoselectivity, broad substrate scope,...The content of this […]Jiangfei Chen
- A One-Step Strategy for Synthesizing N-Formanilide via Benzamide Activation and Oxalic Acid-Driven Reduction July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00941C, CommunicationHeewon Lee, Nithin Pootheri, Chang Woo Kim, Sunwoo LeeA one-step synthetic strategy for directly converting bezamides into N-formanilide derivatives has been developed using oxalic acid as a hydride source. This strategy involves the selective cleavage of the amide...The content of this RSS Feed (c) The Royal Society of […]Heewon Lee
- Directing the chemoenzymatic assembly of desferrioxamine B as a single product using N-tert-butoxycarbonyl-protected substrates July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00982K, PaperTodd E Markham, Athavan Sresutharsan, Callum Andrew Rosser, Rachel CoddDesferrioxamine B (DFOB, 1) is a clinical hydroxamic acid siderophore used as a chelator to treat acute and secondary iron overload disease, with further applications in metal-based radiopharmaceuticals, medicinal chemistry,...The content of this RSS Feed (c) The Royal Society […]Todd E Markham
- Sulphur-containing pyrrolidine-fused chlorins as potential candidates for photodynamic therapy: experimental and theoretical photophysical evaluation July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00753D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Juliana Machado, José Almeida, Tânia M. Ribeiro, Tiago E. C. Magalhães, Valeria Butera, Giampaolo Barone, Ana M.G. SilvaTwo novel sulphur-containing pyrrolidine-fused chlorin derivatives were synthesized through a 1,3-dipolar cycloaddition reaction of meso-tetrakis(pentafluorophenyl)porphyrin with […]Juliana Machado
- Asymmetric synthesis and biological evaluation of ottensinin and its analogues July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01028D, CommunicationJun-Ting Liang, Zichen Xu, Yong-Bin Xie, Wen-Tao Chen, Yu-Tao He, Ya-Jian HuThe asymmetric synthesis ottensinin, a rearranged labdane diterpene with broad range of favorable bioactivites, has been realized based on fragment coupling of 16a and 13 in eight steps from (+)-sclareolide....The content of this RSS Feed (c) The […]Jun-Ting Liang
- Recent progress of glycomimetics in drug development July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00850F, Review ArticleLisi Yuan, Yulian Hua, Xiaolei WangNaturally occurring carbohydrates and glycomimetics have been extensively studied in the treatment of various diseases, in which carbohydrates as the lead, glycomimetics simulate the bioactive function of carbohydrates, and address...The content of this RSS Feed (c) The Royal Society of ChemistryLisi Yuan
- Comparative Study of the Retention of Catalytic Activity of Halonium and Chalconium Cations in the Presence of Crown Ethers July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00584A, PaperIvan O. Putnin, Alexandra A. Sysoeva, Aleksey V. Kovalenko, Dmitrii BolotinThe article explores the retention of catalytic activity of halonium and chalconium triflates, as well as silver(I) triflate, in the Schiff condensation in the presence of crown ethers. It was...The content of this RSS Feed (c) The Royal […]Ivan O. Putnin
- Rapid Construction of Bisindole Alkaloids Caulersin and Racemosin B From Methyl 3-Indolylpyruvate Based on a Biomimetic Dimerization Strategy July 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00925A, CommunicationYutang Gao, Fei Yu, Liang Chen, Sheng LiuAttempts to directly construct bisindole alkaloids caulerpin and caulersin resulted in the discovery of novel synthetic approaches to a specific bisindole framework with a central troponoid core and an unexpected...The content of this RSS Feed (c) The Royal Society of ChemistryYutang Gao
- Palladium-catalyzed reductive cyclization of ortho-vinyl benzoic acids to access 1-indanones July 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00860C, PaperZirun Wang, Chenglong Li, Bin Zheng, Qihang Tan, Qiang Wu, Long Liu, Jacek E. Nycz, Tianzeng Huang, Tieqiao ChenFrom ortho-vinyl benzoic acids, this reaction underwent a tandem process of intramolecular cyclization and hydrogenation, yielding diverse 1-indanones with valuable functional groups in good to high yields.To cite this article […]Zirun Wang
- Stereoselective Total Synthesis of Cytotoxic Cyclodepsipeptide Menominin B: Call for Revision of Proposed Structure July 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01067E, CommunicationSiva Ramakrishna Paipuri, Padyabharati Nayak, Resmi K Raman, SAI BALAJI ANDUGULAPATI, Srihari PabbarajaThe stereoselective total synthesis of the pseudo menominin B is described. A convergent approach involving multi-ester coupling and a peptide coupling, along with key reactions such as Evans aldol and...The content of this RSS Feed (c) […]Siva Ramakrishna Paipuri
- Synthesis of α‑Keto Thioamides via Oxidative Thioamidation of α-Amino Carbonyls Using Hypervalent Iodine Under Neat Conditions July 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00922G, PaperSudip Mondal, Subhankar Sarkar, Anindita Mukherjee, Sougata Santra, Grigory V Zyryanov, Adinath MajeeAn efficient and exceptional method for cleaving the C-N bond in α-amino carbonyl compounds has been developed using N,N,N′,N′-tetraalkylthiuram disulfides (TATD), iodine(III) reagent phenyliodine diacetate (PIDA), and N,N-diisopropylethylamine. The PIDA...The content of this RSS Feed (c) […]Sudip Mondal
- Base-promoted transition-metal-free synthesis of quinazolinones with antioxidant activity July 7, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00734H, PaperMaruboina Hemanth Kumar, Harini G. Sampatkumar, Sanjana S. Talekar, Manoj V. Mane, Vaishnavi Shashidhara, Madhavarani Alwarsamy, B. S. Sasidhar, Ling Shing Wong, Manjula Subramaniam, Meenakshi Verma, Shifa Wang, Asad Syed, Siddappa A. PatilHerein, we describe a transition-metal-free, base-promoted protocol for the synthesis of quinazolinones that utilizes polyethylene glycol […]Maruboina Hemanth Kumar
- Denitrative radical induced coupling reactions of nitroalkenes July 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00904A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marino Petrini, Alessandro PalmieriThe classical reactivity of nitroalkenes, involving the regioselective 1,4-addition by nucleophilic reagents, can be modified in β-nitrostyrenes using free radical species which selectively add to the nitro bearing unsaturated […]Marino Petrini
- Sweet synthesis, precise outcomes: Asymmetric catalysis using carbohydrate-based organocatalysts July 6, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00821B, Review ArticleSamson Lalhmangaihzuala, Khiangte VanlaldinpuiaCarbohydrates, being one of the most abundant biomolecules found in nature, are cost-effective and environmentally biocompatible and hold considerable potential for enhancing the stereoselectivity of asymmetric transformations. These abundant natural...The content of this RSS Feed (c) The Royal Society of ChemistrySamson Lalhmangaihzuala
- Insights into the Temperature-driven Competitive Pericyclic Transformations of Allyloxy Furan July 6, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01036E, CommunicationRishu Narwal, Dinesh Kumar Gopalakrishnan, Janakiram Vaitla, Tarak KarmakarHere, using comprehensive density functional theory calculations augmented by labeling studies, we investigated the mechanistic details of low temperature [3,3]-sigmatropic rearrangement reaction of allyoxy furan and its [4+2]-cycloaddition reaction with...The content of this RSS Feed (c) The Royal Society of […]Rishu Narwal
- Reversible photocycloaddition of 8-pyrenylvinylguanine for photoreactive serinol nucleic acid (SNA) July 4, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00924C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Keiji Murayama, Ayaka Ikeda, Fuminori Sato, Hiroyuki Asanuma8-Pyrenylvinylguanine (PVG) incorporated into serinol nucleic acid (SNA) underwent interstrand photocrosslinking and photocycloreversion.To cite this article before page numbers are assigned, use the DOI form of […]Keiji Murayama
- Supramolecular assembly properties of a mixed-sequence recognition-encoded melamine oligomer July 3, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00769K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mohit Dhiman, Joseph T. Smith, Christopher A. HunterThe self-complementary REMO with sequence DADA was prepared by automated solid phase synthesis. Folding due to intramolecular H-bonding competes with duplex formation due to intermolecular phenol·phosphine […]Mohit Dhiman
- Iodine-Promoted Oxidative Cross-Coupling for the Synthesis of (E)-2-(3-Oxo-3-Phenylprop-1-en-1-yl)-3-Phenylquinazolin-4(3H)-one via C-H Activation: Development of Synthetic TLX Agonists July 10, 2025
