RSC – Org. Biomol. Chem. latest articles- A Perspective on Cysteine-Reactive Activity-Based Probes October 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00905G, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Constantin Marcel Nuber, Max Schwab, David Benjamin KonradActivity-based protein profiling (ABPP) is a powerful method to interrogate protein function, identify protein targets and mechanisms-of-action of chemical probes as well as small molecule […]Constantin Marcel Nuber
- Rhodium-Catalyzed [4+2] Annulation Strategy to Pyranone-Mounted Unnatural Tyrosines with Intrinsic Fluorescence and Anti-Neuroinflammatory Activity October 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01375E, PaperNarendra D Kharat, Sushma Naharwal, Sabyasachi Mandal, Mukul Yadav, T. Govindaraju, Kiran Bajaj, Rajeev SakhujaRh(III)-catalyzed [4+2] annulation of C3Ar -formyl tyrosine ester with internal alkynes furnished di-substituted pyranone-mounted tyrosine-based unnatural amino acids in high yields. Selected compounds exhibited intrinsic viscosity-responsive fluorescence and favorable biocompatibility...The content of this RSS […]Narendra D Kharat
- Light-Induced O-to-C 1,4-Carbonyl Transposition in Salicylaldehyde Derivatives. Umpolung Synthesis of 1,2-Dicarbonyl Compounds and Beyond October 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01527H, PaperVictoria E Opryshko, Alexander Yu. Smirnov, Ivan N Myasnyanko, Andrey A. Mikhaylov, Mikhail S. Baranov, Dmitrii S. IvanovA novel photoinduced umpolung strategy enabling the synthesis of 1,2-dicarbonyl compounds from simple salicylaldehyde derivatives is described. The methods provides α-ketoesters and α-ketoamides in excellent yields (79-90%) under mild photocatalyst-free...The content […]Victoria E Opryshko
- 1,2-Migratory Ring Expansion of a BN Naphthalene October 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01286D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rebekka S. Klausen, Braden A. Mediavilla, Maxime A SieglerOrganoboranes hold an undeniable value in modern organic chemistry and show ever-growing potential in polymer design and functionalization. Azaborines, in particular, are still being explored […]Rebekka S. Klausen
- Amides as key intermediates for the synthesis of 2,4-disubstituted quinazolines via acceptorless dehydrogenative coupling of alcohols October 22, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01152C, PaperYongfei Zhang, Xing Liu, Haiyang Jin, Yingying Qiu, Qing Yan, Yonghai Hui, Zhifeng Ma, Weiwei Jin2,4-Disubstituted quinazolines were effectively synthesized via solvent-free, acceptorless dehydrogenative coupling of renewable alcohols catalyzed by an inexpensive MUV-10(Mn) catalyst in a one-pot approach.To cite this article before page numbers are assigned, use the […]Yongfei Zhang
- Chimeric fungal – firefly luciferins exhibit red shifted fungal bioluminescence October 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01589H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.James C Anderson, Jude I Ayogu, minyan Lyu, Aleksei D Barykin, Anastasia A. Fadeeva, Zinaida M KaskovaA rational design of new luciferins based upon the combination of luciferins from different lineages is exemplified […]James C Anderson
- CF₃S-Triazine for Dehydroxylative Trifluoromethylthiolation of Alcohols October 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01372K, CommunicationYaling Peng, Jun Sun, Xu Yao, Xian-Liang Zeng, Jin-Hong Lin, Xing Zheng, Ji-Chang XiaoDehydroxylative trifluoromethylthiolation of alcohols has garnered significant attention, yet remains a challenging transformation due to the high bond dissociation energy of the C-OH bond. This work reports the use of...The content of this RSS Feed […]Yaling Peng
- Enantioselective access to quaternary stereocenters of pyrrolidines via Rh-catalyzed intramolecular cyclization of 1,6-enynes October 21, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01373A, CommunicationRunqi Hao, Fei Hou, Liqin Liu, Rao Wang, Yuan Tao, Zhenhua Jia, Fen-Er ChenAn enantioselective Rh-catalyzed cyclization of 1,6-enynes using SDP as a ligand has been developed, delivering pyrrolidines bearing quaternary centers in up to 97% ee.To cite this article before page numbers are assigned, use the DOI […]Runqi Hao
- A Complexity-to-Diversity Strategy for Andrographolide Derivation and Discovery of Potential Antiviral and Anticancer Scaffolds October 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01519G, PaperQi Xing, Jiayin Zhang, Jie Yang, Ting Li, Zhendong Zhu, Chao CheStructurally intricate natural products serve as valuable scaffolds in drug discovery, yet efficient strategies to diversify their core frameworks into novel chemical entities remain a significant challenge. Herein, we present...The content of this RSS Feed (c) The […]Qi Xing
- Diastereoselective Construction of Azabicyclo[3.1.0]hexan-2-ones via a Base-Mediated Cascade Annulation of β-oxo-acrylamides with Vinylsulfonium Salts October 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01439E, CommunicationZhaoxue Wang, Ping Wu, Rui Yan, Zhen-guo Zhao, Yuhang Du, Yilei Xiao, Lingang Wu, Lei XieHerein, a DBU-mediated cascade annulation of β-oxo-acrylamides with vinylsulfonium salts has been achieved under mild reaction conditions. This methodology not only provides a direct route for the synthesis of highly...The content of this […]Zhaoxue Wang
- Copper-catalyzed synthesis of glycosyl carboxamides from glycosyl carboxylic acids and isocyanates October 20, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01490E, CommunicationGuo-Zhao Fan, Xiang-Guo Hu, Shuai LiuWe report a copper-catalyzed protocol for synthesizing glycosyl carboxamides from glycosyl carboxylic acids and isocyanates. This method features a broad substrate scope, mild conditions and high atom economy.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Guo-Zhao Fan
- 2-(2-Tosylhydrazineylidene)acetyl chloride: An Unexplored Diazo Reagent for the Synthesis of Cyclopropane Fused Dihydroquinolones October 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01381J, PaperVelu Rathinam, Tony Anthappan Kurissery, Sathya Shanker P. , Vipin A. NairCyclopropane fused dihydroquinolones are prevalent in numerous biologically active compounds and exemplify important scaffolds in medicinal chemistry. We herein describe a wide scope methodology for the direct and modular synthesis...The content of this RSS Feed (c) The […]Velu Rathinam
- Phthalimide-based sulfur transfer reagents for the preparation of biologically relevant trisulfides October 19, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01481F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Conrad N. A. Du, Austin Sarker-Young, Meg Shieh, Stephen Lindahl, Ming XianPhthalimide-based disulfides are used to readily prepare trisulfides on both small molecule and protein substrates.To cite this article before page numbers are […]Conrad N. A. Du
- Access to Functionalized Benzo[b]fluorene/Benzo[a]anthracene Derivatives Through TfOH-Promoted Tandem Isomerization/Cyclodehydration October 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01225B, PaperRajkamal Sahoo, Sourav Ghosh, Asadujjaman Nur, Kush Mandal, Gopal Rana, Umasish JanaWe report a new and efficient protocol to access functionalized benzo[b]fluorenes/benza[a]anthracenes via triflic acid mediated tandem isomerization/cyclodehydration of 1-benzylidene-2,3-dihydroindene/1-benzylidenetetrahydronaphthalene derivatives. Palladium-catalyzed intramolecular domino Heck-Suzuki coupling reaction of alkyne tethered 2-bromobenzene...The content of this RSS Feed (c) The […]Rajkamal Sahoo
- Catalyst-free C−H Bond Halogenation/Imidation of N-heterocycle October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01463H, CommunicationMiao Liu, Xueying Zhang, Nan Li, Xu Zhang, Congyong Zhao, Xiaobao Shen, Hongbin Zhai, Fufang WuThe application of N-halosuccinimides (NXS) as "nucleophilic" nitrogen sources in organic transformations represents an emerging and promising area of research. This work utilized the two key intermediates-X-radicals and N-radicals-generated synchronously...The content of this […]Miao Liu
- Synthesis of Tetrahydropyrrolo[1,2-a]quinolinone Analogues via CoCl2/AgSbF6-Catalyzed Cyclization of Unactivated N,O-Acetals with Olefins October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01374G, PaperBangguo Wei, Xin Li, Yu Zhang, Yu-Ying Zhang, Chang-Mei Si, Qiao-E WangA convenient method to access functionalized tetrahydropyrrolo[1,2-a]quinolinone skeletons has been achieved through a CoCl2/AgSbF6-catalyzed Povarov reaction of unactivated N-Ar N,O-acetals with styrene-type olefins. As a result, a series of 5-substituted...The content of this RSS Feed (c) The […]Bangguo Wei
- Trichosterol A, a unique 6/6/6/5/6-fused steroid-alkaloid hybrid with bioherbicidal activity from Trichoderma koningiopsis October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01352F, CommunicationShuyuan Mo, Jian Yang, Jie Zhao, Jianping Wang, Yonghui Zhang, Zhengxi HuNaturally occurring steroids constitute a class of pharmacologically privileged scaffolds, owing to their rigid tetracyclic frameworks and well-defined stereochemistry, which have served as the basis for numerous clinically important drugs....The content of this RSS Feed (c) The […]Shuyuan Mo
- Synthesis of hexahydroisobenzofuran-1(3H)-ones via pyridine-boryl radical-catalyzed intramolecular cascade cyclization of alkene-tethered cyclobutyl ketones October 16, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01566A, CommunicationXiao-Ye Yang, Hua Huang, Qiong Wu, Yun-Xuan Tan, Ping TianThe first pyridine-boryl radical-catalyzed intramolecular formal [4 + 2] cycloaddition of alkene-tethered cyclobutyl ketones has been successfully realized.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Xiao-Ye Yang
- Digold photosensitizer for visible light [2 + 2] cycloaddition and E/Z isomerization reactions October 16, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01503K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tommaso Ruggiero, James Fortwengler, Kristof Van Hecke, Mark E. Thompson, Thomas S. A. Heugebaert, Steven P. NolanEnergy transfer photocatalysis has emerged as a powerful platform for a variety of transformations, yet advances in […]Tommaso Ruggiero
- Diastereoselective amidoboronate formation and transformation from a rac to a different meso amidoboronate via dynamic C–C bonds October 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01479D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patrick Harders, Tim Raeker, Lorenz Pietsch, Christian Näther, Bernd Hartke, Anna J. McConnellWe report diastereoselective amidoboronate synthesis and the transformation from rac isomers to a different meso amidoboronate via dynamic C–C bonds.To cite […]Patrick Harders
- A Perspective on Cysteine-Reactive Activity-Based Probes October 23, 2025
