RSC – RSC Chem. Biol. latest articles- P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide July 23, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00153F, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon PhanThe uncharacterized cytochrome P450 cyptide synthase MpoB from Micromonospora polyrhachis DSM 45886 catalyzes a cross-link between Tyr-C3 and […]Abujunaid Habib Khan
- Semi-enzymatic synthesis and application of 13C-isotopically labelled inositol-(1,4,5)-trisphosphate July 22, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00139K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Atharva Patharkar, Meike Amma, Jaime Isern, Zoé Chaudron, Angélique Besson-Bard, Valérie Nicolas-Francès, Claire Rosnoblet, David Wendehenne, Peter Schmieder, Dorothea FiedlerInositol(1,4,5)trisphosphate (Ins(1,4,5)P3) is a crucial secondary messenger that controls calcium (Ca2+) levels inside cells, […]Atharva Patharkar
- Defining STING-sterol interactions with chemoproteomics July 20, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00171D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ian Ford, Miranda Villanueva, Min Sub Lee, Quan D Zhou, Constance Yuen, Robert D Damoiseaux, Steven Bensinger, Keriann M. BackusStimulator of interferon genes (STING) is an intracellular pattern recognition receptor that plays a […]Ian Ford
- Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin July 18, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00124B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nils Imse, Lucia Rojas, Cristina Gil Herrero, Sebastian Thallmair, JeongSeop Rhee, Nadja SimethLight-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable […]Nils Imse
- Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition July 17, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00106D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander Dahlqvist, Rob Marc Go, Chandan Kishor, Hakon Leffler, Helen Blanchard, Ulf J. NilssonGalectins are a family of carbohydrate-recognising proteins involved in regulation of cell adhesion and cell signaling, leading to roles in […]Alexander Dahlqvist
- Discovery of an Exquisitely Selective WDR5 Chemical Probe Accelerated by a High-Quality DEL-ML Hit July 16, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00109A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lasse Hoffmann, Christopher Lenz, Frederic Farges, Serah W. Kimani, Johannes Dopfer, Sabrina Keller, Martin P. Schwalm, Hanna Holzmann, Andreas Krämer, Aiping Dong, Fengling Lu, Irene Chau, Levon Halebelian, Matthias Gstaiger, Susanne Müller, Stefan […]Lasse Hoffmann
- Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation July 16, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00159E, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinghua Wu, Huapeng Li, Adam R. Lovato, Andrew Symasek, Zeng Lin, Qingfei ZhengA pH-controlled regioselective rapid ene-type reaction (RRER) was developed for the specific bioconjugation of a novel epigenetic mark, histone serotonylation, where […]Jinghua Wu
- Chemoenzymatic synthesis of sialylated and fucosylated mucin analogs reveals glycan-dependent effects on protein conformation and degradation July 13, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00111K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amanda M. Wood, Casia L. Wardzala, Jessica R. KramerSynthetic mucins with tunable glycosylation were prepared by a combination of NCA polymerization and enzymatic sialylation and fucosylation and were used to probe glycan-dependent effects […]Amanda M. Wood
- Unravelling Structure-function Interactions Between Fluorinated Heparan Sulfate Mimetics and Signaling Proteins July 9, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00174A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Virendrasinh Mahida, Rakesh Raigawali, Paula González, Ana Gimeno, Shani Leviatan Ben-Arye, Saurabh Anand, Sandhya Mardhekar, Jesus Jimenez-Barbero, vered Padler-karavani, Raghavendra V KikkeriFluorinated carbohydrates are emerging scaffolds in glycobiology, enabling the elucidation of the […]Virendrasinh Mahida
- Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein July 9, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00141B, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tommaso Garfagnini, Zvi Hayouka, Assaf FriedlerRandom peptide mixtures target multiple hotspots at once and inhibit the aggregation of the Axin RGS L106R protein more effectively than hotspot-specific inhibitors, providing a chaperone-inspired protection against […]Tommaso Garfagnini
- P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide July 23, 2025
