Nanosilver replaces antibiotics in swine industry – a trial study

The current situation of antibiotic resistance in the livestock industry has been warned and concerned by the authorities. Finding alternative solutions is necessary and pays more attention. Nanosilver is known in recent years for its antibacterial, growth stimulating and can replace antibiotics, more effective than some safe products such as microorganisms, organic acids, Oligosaccharide …


(Copyright by NanoCMM Technology)


In Vietnam, about 80% of pork is produced by smallholder farmers, who often use antibiotics to prevent disease and promote growth due to low cost and lack of knowledge or concerns by farmers. the use of antibiotics (AMU).

  • To reduce the use of AMU antibiotics in livestock, it is necessary to define how farmers can benefit from mitigation to promote behavior change.

Objective: to test a farm-level intervention to reduce AMU and antibiotic resistance (AMR) by replacing feed antimicrobials with nanosilver, the most commonly used antimicrobial agent in surface treatment and packaging

A nanosilver versus antibiotic amoxicillin-based feeding study was tested on 60 35-day-old pigs for a period of 4 months. The study results showed no significant difference in the efficacy of nano silver and amox antibiotic. The results showed that nanosilver in antibiotic replacement was positive.


Experimental procedure comparing nano silver and antibiotic

  • Mass measurement method: start (T0), after 1 month (T1), after 2 months (T2), after 3 months (T3), and after 4 months (T4) to estimate average daily increase
  • Antibiotic resistance of E.Coli: monthly stool sample and floor water samples T0, T1, T2, T3, T4
  • Antibiotic residues: in the pork of T4


Average weight increase according to survey time

  • Average weight gain after different measurement times (in grams / day)
  • There was no significant difference observed between the control group and the intervention group at all times of measurement (p> 0.05).
  • The prevalence of E. coli in both feces and floor samples was 100%.

The level of antibiotic resistance and antibiotic residues by type

  • The rate of antibiotic resistance is high to the most commonly used antibiotics
  • There was no significant difference in the AMR antibiotic resistance profile of E. coli between the control group (not using) and the antibiotic treatment group.
  • No antibiotic residue was found in pork from the nano-silver group. One (out of six) pork samples from the control group (antibiotic group) were found to have amoxicillin at 26.3 µg / kg (compared with 50 µg / kg as MRL for Amoxicillin in pork) during the period. The storage period is 7 days.


  • The use of silver nanoparticles in place of antibiotics added to the feed showed no difference in mean weight gain (ADG), nor in the antibiotic resistance (AMR) profile of E. coli in swine production. small scale.
  • These test results show a viable alternative to using antibiotics in swine production to reduce AMU and AMR.
  • Evidence of efficacy, cost benefit, farmer acceptability, resistance, risk assessment of switching to pork and environmental impact assessment of nano silver is required before scaling up use

Reference: Alternative to antibiotic in pig production: A Nano silver use trial

Hung Nguyen-Viet, Huyen Nguyen-Van, Trang Le-Thi-Huyen, Fred Unger, Thang Tran-Quang,
Yen Luu-Thi-Hai, Khong Nguyen-Viet, Hu Suk Lee, Jane Pool, Delia Grace
International Livestock Research Institute, National Institute of Veterinary Research, Vinh Phuc animal health and livestock sub-department