RSC – Nat. Prod. Rep. latest articles- Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications June 26, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00027K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D. Keasling, Byung-Kwan ChoSynthetic protein interfaces enable programmable assembly of PKS […]Gahyeon Kim
- The ballet of nature: the interconvertible isomerisation of natural products June 22, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00019J, Review ArticleZe-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang LouThis review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers found in nature, including positional, tautomeric, geometric, optical, and conformational isomerism.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Ze-Jun Xu
- The chemical and biological properties of natural resorcylic acid lactones June 18, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00033E, Review ArticleYing Gao, Wanpeng Li, Hanli RuanThis review highlights the classification, structures, origins, biotargets, and clinical studies of naturally derived resorcylic acid lactones, a valuable polyketide template for drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Ying Gao
- Mass spectrometry-based metabolomics approaches to interrogate host–microbiome interactions in mammalian systems June 15, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00021A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Atharva S. Kulkarni, Guilherme M. P. Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall, Neha GargChemical crosstalk is universal to all life, niche-specific, and essential to thrive.To cite this article before […]Atharva S. Kulkarni
- Exploring microbial natural products through NMR-based metabolomics June 11, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00065J, Review ArticleDe-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng WuNMR-based metabolomics—whether applied independently or harmonized with genomics—offers a potent lens into microbes' chemical repertoire. The judicious integration of artificial intelligence (AI) further amplifies the potential of this advanced methodology, ushering in new frontiers for microbial […]De-Gao Wang
- Natural products in antiparasitic drug discovery: advances, opportunities and challenges June 11, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00007F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaofei Shang, Lixia Dai, Xinyuan Cao, Yudong Ma, Ilgekbayeva Gulnaz, Xiaolou Miao, Xiuhui Li, Xiaorong YangIn this review, we discuss the strategies used for developing drugs from natural resources and mainly describe […]Xiaofei Shang
- Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids June 9, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00025D, HighlightChungwoo Lee, Sunkyu HanThis Highlight reviews the discovery, structure elucidation, (bio)synthesis, and applications of securingines A–I, highly oxidized securinega alkaloids with unique structures.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Chungwoo Lee
- Trends in metabolite discovery from Actinomycetes June 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00075G, Review ArticlePaolo Monciardini, Matteo Simone, Marianna Iorio, Sonia I. Maffioli, Margherita Sosio, Stefano DonadioActinomycetes continue to provide new molecules at a steady rate. Here we analyze the contribution of four approaches to the discovery of new metabolites, and which strategies are more effective at yielding structurally original molecules.To […]Paolo Monciardini
- Advances in the discovery and study of Trichoderma natural products for biological control applications June 5, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00017C, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sophie Jin, Fabrizio AlbertiTrichoderma spp. are talented producers of bioactive natural products, with applications in crop protection and growth promotion. We describe methods for the discovery of these compounds focused mainly on […]Sophie Jin
- Hot off the Press June 4, 2025Nat. Prod. Rep., 2025, 42,945-949DOI: 10.1039/D5NP90022K, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as shimianolide A from Chloranthus holostegius var. shimianensis.The content of this RSS Feed (c) The Royal Society of […]Robert A. Hill
- Dietary substances and their glucuronides: structures, occurrence and biological activity June 3, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00002E, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Andrew V. Stachulski, Edwin A. Yates, Aleksandra Teriosina, Lesley Hoyles, Simon McArthurWe survey glucuronides of polyphenolic dietary substances and discuss their activities in comparison to those of the parent compounds. We finally consider […]Andrew V. Stachulski
- Technological developments driving industrial natural product discovery June 3, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00072B, Review ArticleRichard Lewis, Richard Hammond, Mark Wilkinson, Nick AllenbyA new era of antimicrobial discovery: reviewing the limits of traditional methods and the potential for new techniques to discover from previously inaccessible biosynthetic diversity.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Richard Lewis
- Illuminating the dark space of bioactive peptides with mass spectrometry March 11, 2025Nat. Prod. Rep., 2025, 42,950-955DOI: 10.1039/D4NP00057A, Viewpoint Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicole C. Parsley, Leslie M. HicksWith emerging resistance and a lag in the development of new molecules, bioactive natural product peptides are a source of new chemistries to drive advances in medicine and biotechnology.The […]Nicole C. Parsley
- ‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes February 27, 2025Nat. Prod. Rep., 2025, 42,1037-1054DOI: 10.1039/D4NP00053F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Robert A. Shepherd, Conrad A. Fihn, Alex J. Tabag, Shaun M. K. McKinnie, Laura M. SanchezIn this review we highlight recent advancements in mass spectrometry that have allowed for more efficient, robust, and […]Robert A. Shepherd
- The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives February 24, 2025Nat. Prod. Rep., 2025, 42,965-981DOI: 10.1039/D4NP00034J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wanessa Francesconi Stida Peixoto, Renato Crespo Pereira, Esthfanny dos Santos Souza Azevedo, Fernando Martins dos Santos, Ricardo Coutinho, Louisi Souza de OliveiraIn this article, we review the key processes contributing to the chemical […]Wanessa Francesconi Stida Peixoto
- Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics February 20, 2025Nat. Prod. Rep., 2025, 42,1020-1036DOI: 10.1039/D4NP00064A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Morgane Mauduit, Stéphane Greff, Marie Derrien, Charlotte SimmlerThis review highlights advances in characterizing exometabolites (EMs) from benthic organisms, starting with in situ sampling methods, then discussing how marine MS-based (exo)metabolomics benefits various fields […]Morgane Mauduit
- Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products January 20, 2025Nat. Prod. Rep., 2025, 42,956-964DOI: 10.1039/D4NP00026A, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brett C. Covington, Mohammad R. SeyedsayamdostNatural products have traditionally been discovered one molecule at a time. Here we describe new innovations in the acquisition and analysis of mass spectrometry data that now enable metabolomics-guided […]Brett C. Covington
- Effective data visualization strategies in untargeted metabolomics December 2, 2024Nat. Prod. Rep., 2025, 42,982-1019DOI: 10.1039/D4NP00039K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kevin Mildau, Henry Ehlers, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber, Justin J. […]Kevin Mildau
- Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications June 26, 2025
