RSC – Org. Biomol. Chem. latest articles- Recent Advances in Pd-Catalysed Decarboxylative Asymmetric Allylic Alkylation December 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01686J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Niamh Lehane, Patrick J GuiryThis comprehensive review on the Pd-catalysed decarboxylative asymmetric allylic alkylation details the development of this important transformation from its origins to more recent advances. Selected examples of this […]Niamh Lehane
- Synthesis-Enabled Conformational Assignment of Natural N-Acyl L-Phenylalanine Derivatives from Freshwater Sponge-Associated Micromonospora sp. MS-62 December 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01886B, CommunicationJiyool Kim, Jueun Kang, Yongseong Han, Jinchan Sim, Young-Joo Kim, Ja Young Cho, Taejung Kim, Young Tae Park, Jaeyoung KwonThis study demonstrates a concise four-step total synthesis of N-acyl-L-phenylalanine derivatives (P1–P5) from Micromonospora sp. MS-62 enabling definitive assignment of the S configuration at C-1′ via single-crystal X-ray diffraction. […]Jiyool Kim
- High-throughput DoE synthesis of chalcones and pyrazolines for fluorescent sensing December 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01684C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander CiupaPyrazolines are attractive scaffolds for fluorescent sensors due to their unique photophysical properties and the ease of their synthesis from chalcone precursors. While both chalcones and pyrazolines have been widely...The content of […]Alexander Ciupa
- Catalytic asymmetric 1,6-type Friedel–Crafts (hetero)arylations of δ-Cyano substituted para-quinone methides with 5-aminopyrazoles December 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01738F, CommunicationShi-Na Zhao, Hui-Qiao Song, Yi Hu, Fen Gao, Yonghui He, Xiao-Jing ZhaoTriarylmethanes is a privileged motif in numerous biologically significant natural molecules and materials. Herein, we achieved a highly efficient enantioselective 1,6-type Friedel–Crafts (hetero)arylations of δ-Cyano substituted para-quinone methides with 5-aminopyrazoles....The content of this RSS Feed (c) The […]Shi-Na Zhao
- Sustainable electrochemical synthesis of a new isoxazoline scaffold as turn inducer to build parallel β-hairpins December 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01798J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zoe Laface, Gianluigi Broggini, Camilla Loro, Davide D.D.L. Di Lorenzo, Giovanni Macetti, Alessandro Contini, Maria Luisa Gelmi, Kaliroi Peqini, Raffaella BucciNew diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar […]Zoe Laface
- Synthesis of the Aminoglucuronic Acid Glycans from the Capsular Polysaccharide of Staphylococcus aureus type 2 December 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01793A, Paper Jintao Shang, Yikun Yu, Jinfeng Lin, Dongsheng Chang, Lvfeng Zhang, Liming Zhao, You YangThe escalating antibiotic resistance of Staphylococcus aureus has made glycoconjugate vaccines targeting its surface polysaccharides a highly promising strategy for preventing staphylococcal infections. However, the development of a type 2-specific...The content of this RSS […]Jintao Shang
- Electrochemical Cross-Electrophile Coupling of Unactivated Tertiary Alkyl Bromides with Benzyl Chloride to Access Quaternary Stereocenters December 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01873K, CommunicationYun Yang, Shaokun Tao, Li Chen, Yi Tan, Jiaqi Xu, Haiyan Fu, Ruixiang Li, Hua Chen, Weichao Xue, Xueli ZhengConstructing quaternary carbon centers represents a significant yet challenging work in synthetic and medicinal chemistry. Herein, we report an efficient electrochemical nickel-catalyzed reductive crosselectrophile coupling for the modular synthesis […]Yun Yang
- Impact of phenothiazine-to-phenoxazine replacement in hexaphyrin frameworks on structural, spectroscopic, and redox properties December 18, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01774B, PaperNeha Tripathi, Mangalampalli RavikanthThree phenoxazine-embedded hexaphyrins were synthesized by replacement of phenothiazine with phenoxazine which induces a complete flip of the heterocyclic unit which profoundly modulates the macrocyclic architecture and electronic properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Neha Tripathi
- Recent advances in the synthesis of indolo[2,1-a]isoquinolines from N-acryloyl indole derivatives December 18, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01691F, Review ArticleKaixue Xie, Dongmei Chi, Jianbo Wang, Shufeng ChenThis review presents a comprehensive overview of recent synthetic strategies for constructing indolo[2,1-a]isoquinoline derivatives from N-acryloyl indole precursors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Kaixue Xie
- 4-chloro-2H-chromene-3-carbaldehyde: A Valid Scaffold in Organic Synthesis and Future Molecules for Healthcare and Energy December 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01889G, Review ArticleGuruprasad Rameshbabu, Sabbasani Rajasekhara ReddyIn the past decade, 4-chloro-2H-chromene-3-carbaldehyde scaffolds (CCCS) have gained significant interest in organic synthesis and medicinal chemistry. Due to the reactivity of this scaffold with various organic molecules, this review...The content of this RSS Feed (c) The Royal Society of ChemistryGuruprasad Rameshbabu
- Ferric nitrate-mediated synthesis of functionalized 1,2,3-benzotriazinones from 2-aminobenzamides and 2-nitrobenzamides via nitrate reduction strategy December 17, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01821H, PaperSachu Kuriakose, Sruthi S. Nair, Jeyakumar KandasamyAn efficient protocol has been established for synthesizing 1,2,3-benzotriazinones and related heterocycles from 2-aminobenzamides and 2-nitrobenzamides using iron(III) nitrate and sulfur-based reductants via the nitrate reduction strategy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Sachu Kuriakose
- Synthesis and evaluation of analogs of tetracyclic Ganoderma alkaloids as inhibitors of the enzyme α-glucosidase December 17, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01787D, PaperL. Javier Cala Gomez, Natalia L. Calvo, Mario O. Salazar, Sebastian O. Simonetti, Ricardo L. E. Furlan, Andrea B. J. Bracca, Teodoro S. KaufmanHighly active α-glucosidase inhibitors (up to 41 times more potent than acarbose) were synthesised, mimicking ganocochlearines, tetracyclic Ganoderma alkaloids.To cite this article before page numbers […]L. Javier Cala Gomez
- New core-expanded calix[4]pyrroles and N-donor-extended dipyrromethanes: syntheses, anion binding and conformational studies December 17, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01716E, PaperSoumya Mishra, Monalisa Giri, Vipin Kumar Mishra, Tapas GuchhaitThe syntheses, characterization studies, preliminary anion binding, and anion-induced or meso-substitution-dependent conformational behaviours of a few novel dipyrromethane-based Mannich bases are highlighted.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Soumya Mishra
- Synthesis of morpholine derivatives from 1,3-dienes and N-arylaminoalcohols by palladium-catalyzed sequential C–N and C–O bond formation December 17, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01744K, CommunicationAyumi Yamaguchi, Nobuki Katayama, Kazuki Tabaru, Tetsuaki Fujihara, Yasushi OboraPalladium-catalyzed oxidative coupling of 1,3-dienes and N-arylaminoalcohols using copper salt, 1,4-benzoquinone, and molecular oxygen affords morpholine derivatives under mild conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Ayumi Yamaguchi
- Photoinduced radical addition of 4-alkyl-1,4-DHPs to vinyl azides December 17, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01647A, PaperZhiqin Zhang, Xirui Zhang, Jiajing Tan, Hongguang Du, Ning ChenThis work presents a photoinduced radical addition of 4-alkyl-1,4-DHPs to vinyl azides for ketone synthesis. Single- and dual-parameter Hammett analysis clarifies the silver-mediated activation of vinyl azides for low-reactivity radicals.To cite this article before page numbers are assigned, use […]Zhiqin Zhang
- Enabling the serodiagnosis of American tegumentary leishmaniasis using synthetic aminopentyl-galactofuranoside-containing oligosaccharide epitopes December 16, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01900A, PaperCarolina S. Touloumdjian, Emelie E. Reuber, Fabienne Weber, Renato E. Uncos, Eleonora Elhalem, Ana Bellomo, María J. Comin, Jorge D. Marco, Peter H. Seeberger, Lucía Gandolfi DonadíoFive galactofuranosides resembling Leishmania braziliensis type II GIPLs were synthesized and tested against sera from American tegumentary leishmaniasis patients, revealing selective epitopes […]Carolina S. Touloumdjian
- Synthesis of unsymmetrical thiosulfonates via ring-opening reaction of cyclic sulfonium salts with sodium thiosulfonates December 16, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01800E, PaperQing-Ling Chen, Hao-Pan Tan, Sha Peng, Li-Hua Yang, Long-Yong XieA practical and efficient ring-opening reaction of cyclic sulfonium salts with sodium thiosulfonates for the synthesis of various unsymmetrical thiosulfonates has been developed under catalyst-, oxidant-, and additive-free conditions.To cite this article before page numbers are assigned, use the […]Qing-Ling Chen
- Anion recognition in water by a simple bis-squaramide with charge-enhanced acidity December 16, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01894C, PaperChen Dong, Kehao Zhang, Junhong Li, Jihao Wang, Wenrui Lyu, Xuanxuan Chen, Xin WuA non-macrocyclic bis-squaramide receptor featuring charge-enhanced hydrogen bonding sites binds charge-dense anions in water with up to micromolar affinity levels.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Chen Dong
- Modular and chromatography-free synthesis of natural linear polyamines December 16, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01807B, PaperMasato Takahashi, Teruyuki Kobayashi, Takuya Noguchi, Seisuke Mimori, Masakiyo Hosokawa, Takashi Fukui, Akira Takagi, Nobuaki Okumura, Hiroshi Kawabe, Takanori Yano, Naomi Ohta, Akihisa Hata, Ryoji Mitsui, Noboru FujitaniA concise, column-free synthetic route to polyamines was developed using diamines and amino acid derivatives with varying carbon chain lengths. This […]Masato Takahashi
- Gold-catalyzed amination of in situ formed alkyl gold species with p-quinonediimines as a N source December 16, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01823D, PaperXinyu Pan, Yusuf Abdulla, Ming Bao, Xinfang XuHerein, a gold-catalyzed electrophilic propargyl amination reaction of N-propargylamide using p-quinonediimines as a N source has been presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Xinyu Pan
- Recent Advances in Pd-Catalysed Decarboxylative Asymmetric Allylic Alkylation December 24, 2025
