RSC – Org. Biomol. Chem. latest articles- Electrochemical direct site-selective selenation of carbazoles March 27, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00206D, PaperHaodong Ma, Wei Xu, Haomin Chen, Bin Wang, Ziren Chen, Yu Xia, Shaofeng Wu, Weiwei Jin, Chenjiang Liu, Yonghong ZhangAn electrochemical direct site-selective selenation of carbazoles has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Haodong Ma
- Ultrafast Fluorescent Detection of Mercury(II) Ions in Aqueous and Biological Systems Using a Sulfur-Free Boronic Acid-Based Reaction Probe March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00170J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kishor Khadka, Sumita Subedi, Eun-Taex Oh, Keun-Hyeung LeeA new reaction-based fluorescent chemodosimeter for Hg²⁺ ions was developed based on the irreversible substitution reaction between Hg²⁺ and a phenylboronic acid moiety. The probe exhibits […]Kishor Khadka
- Metabolic Labeling and Imaging of Native Saccharomyces Cerevisiae Glycan by Using N-Acetylglucosamine-6-Phosphate Analogs March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00192K, PaperNianci Li, Jiaxin Feng, Shuhui Ji, Bin Fu, Hui Zhang, Tianyou Jiao, Qichan Yi, Nicholas Gong, Yimei Guo, Huijuan Ji, Yishu Yan, Pan Zhu, Jialin Liu, Yuntao ZhuN-acetylglucosamine (GlcNAc) is an essential component of fungal glycans, which are found in N-linked glycans, chitin polysaccharides in the cell wall, […]Nianci Li
- Metal Triflimide-Mediated Acylation of Sulfonamides and Transacylation of N-Acylsulfonamides † March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00269B, PaperShimin Yang, Ying Peng, Shujie Li, Juan Tian, Dayong SangA method for the acylation of sulfonamides and transacylation of N-acylsulfonamides has been developed. The acylation proceeds smoothly in the presence of Cu(NTf2)2 (0.1 mol%) using carboxylic anhydrides, acyl chlorides,...The content of this RSS Feed (c) The Royal Society […]Shimin Yang
- Expediated synthesis of N-acyl-N-alkyl sulfonamide probes for protein proximity labelling March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00339G, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Phathu Masithi, Laetitia Raynal, Peter O'Brien, Christopher D. SpicerN-Acyl-N-alkysulfonamides (NASAs) can be used to site-selectively label proteins via proximitymediated reactions. However, the synthesis of NASA probes can be challenging, typically using a two-step […]Phathu Masithi
- Rh(III)-Catalyzed Cascade C-H Activation/Amination Enables the Synthesis of 1,2-Disubstituted Benzimidazoles from Amidines and Arynes March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00074F, CommunicationFen Xu, Shi-Yu Zhang, Jia-Qi Huo, Fan-Wang Zeng, Fu-Kang Zhou, Luciano BarboniBenzimidazoles are versatile and indispensable scaffolds widely used in organic synthesis. Herein, we report a Rh(III)-catalyzed cascade C-H activation/amination reactions between amidines and arynes, enabling the efficient synthesis of 1,2-disubstituted...The content of this RSS Feed (c) The […]Fen Xu
- Rapid Catalyst-Free Synthesis of α-Selenomethyl Ketones from Sulfoxonium Ylides and Selenols † March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00428H, PaperXuyang Gong, Huaiyu Huang, Taiwen Li, Qichen Liu, Xiaoqiong Fu, Haifeng Wang, Hao Zhoud, Shuangxi GuA rapid and catalyst-free synthesis of α-arylselenomethyl ketones has been developed via the direct coupling of sulfoxonium ylides with benzeneselenol. This metal-free protocol operates under mild conditions, exhibits excellent functional...The content of this […]Xuyang Gong
- Cycloaddition of Benzo[d]thiazoles with Imidazol-4-one Activated Donor-Acceptor Cyclopropanes. Synthesis of Spirocyclic Inhibitors of HIV-1 March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00180G, CommunicationViktoria A. Ikonnikova, Olga Shchigal, Andrey Anisenko, Pavel N. Solyev, Grigory A. Krylkov, Alexander R. Romanenko, Alexander Korlyukov, Mikhail S. Baranov, Marina Gottikh, Andrey A. MikhaylovThe reaction of benzo[d]thiazoles with imidazol-4-one activated donor-acceptor cyclopropanes (DACs) represents a practicable cycloaddition resulting in new spirocyclic compounds. DACs react with a […]Viktoria A. Ikonnikova
- Practical and robust access to enimides via DMAPO-catalyzed coupling of carboxylic acids with secondary enamides March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00367B, PaperXianghe Wu, Feng Yu, Li Zhang, Yewen FangHerein, a new protocol for the preparation of α-aryl N-vinylimides has been successfully developed. With carboxylic acids as the acyl source, a range of N-vinylamide could react with carboxylic acids...The content of this RSS Feed (c) The Royal Society of ChemistryXianghe Wu
- Discovery of artemargyins A-E: rare 9'-nor-dibenzylbutane lignans and a lignan-coumarin hybrid with antihepatic fibrosis activities from Artemisia argyi var. gracilis March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00214E, PaperYing Wu, Ze Ma, Yong-Xiang Huang, Tian-Ze Li, Yong-Cui Wang, Ji-Jun ChenArtemargyins A-E (1-5) along with three known compounds (6-8) were isolated from Artemisia argyi var. gracilis. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data, theoretical ECD calculations...The content of this RSS Feed (c) The […]Ying Wu
- Recent Advances in Organocatalytic Enantioselective Construction of Alkynyl-Containing Tetrasubstituted Carbon Stereocenters March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00306K, Review ArticleJiaying Yin, Yu Li, Junbing LinAlkynyl-containing tetrasubstituted carbon stereocenter represents a frequently encountered structural motif in a series of biologically active molecules. Furthermore, the presence of alkyne-containing tetrasubstituted carbon stereocenters in a molecule offers a...The content of this RSS Feed (c) The Royal Society of ChemistryJiaying Yin
- Recursive Anionic γ'-Spiro-annulation of Cyclic Vinylogous Esters with 2-Vinylbenzoates March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00163G, CommunicationChia-Chen Chien, Grace Victoria Govada, Li-Ching Shen, Yen-Ku WuWe report a γ'-selective anionic cascade spiroannulation between cyclic vinylogous esters (CVEs) and 2-vinylbenzoates. This transformation proceeds with high γ'-selectivity, enabling CVEs to function as γ',γ'-dianionic equivalents while engaging 2-vinylbenzoates...The content of this RSS Feed (c) The Royal Society of […]Chia-Chen Chien
- Affinity enhancement of polo-like kinase 1 polo-box domain-binding peptides by N-methylation and lipidation March 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00193A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kohei Tsuji, Kenan Bai, Xueyuan Huang, Hirokazu TamamuraSynthesized Plk1 PBD-binding peptides with N-methylation exhibited up to 4-fold improved PBD affinities and with lipidation demonstrated up to 260-fold improved PBD affinities as compared with […]Kohei Tsuji
- Betaine–ZnO hybrid catalyst: a sustainable bifunctional system for solvent-free Knoevenagel condensation March 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00300A, PaperLema Deme Shumi, Mateusz Pilszek, Magdalena Grabowska, Sebastian Jurczyk, Dariusz Łukowiec, Piotr LatosA sustainable betaine–ZnO hybrid catalyst was synthesized via a simple mixing approach between betaine hydrochloride and zinc oxide.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Lema Deme Shumi
- Recent developments in asymmetric synthesis of cyclohepta[b]indole derivatives March 24, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00275G, Review ArticleReena Jangir, Jyothi Yadav, Eldhose Iype, Sravendra Rana, Indresh KumarThis review article covers the current state of asymmetric synthetic methods for functionalized cyclohepta[b]indoles, which have attracted significant interest due to their presence in many bioactive compounds.To cite this article before page numbers are assigned, use the DOI form of […]Reena Jangir
- Electrochemical Regioselective C-3 Amination of Imidazo[1,2a]pyridines with Electron-Deficient Sulfonimides March 24, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00273K, PaperWenji Zhang, Kaiye Wu, Changdi Zheng, Guan Wang, Weihui Zhong, Fei LingThe development of sustainable methods for the C-H amination of imidazo [1,2-a]pyridines is of significant interest in medicinal chemistry. While electrochemical C-H amination has proven effective for electron-rich amines, the...The content of this RSS Feed (c) The […]Wenji Zhang
- Synthesis of the conjugation-ready β-D-rhamnose and β-D-mannose containing trisaccharide O-antigen from Serratia spp. Strains 10.1WK and 1XS March 24, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00268D, PaperSanajit Maiti, Akash Patra, Balaram MukhopadyaySynthesis of the target trisaccharide O-antigen has been accomplished by following a linear strategy. The challenging 1,2-cis mannoside at the reducing end is prepared from a suitably protected glucoside derivative...The content of this RSS Feed (c) The Royal Society of ChemistrySanajit Maiti
- Non-Catalytic Low-Cost and Sustainable Amidation using a Twisted Amide March 24, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00340K, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takefumi Kuranaga, Ai Koyama, Kosuke Shimizu, Tensei Tokuda, Hideaki KakeyaCost reductions and environmental friendliness have been strongly desired in amide synthesis. In this study, carboxylic acid was converted to a twisted amide using […]Takefumi Kuranaga
- Synthesis of allomaltol containing pyridazines and their photochemical transformation into substituted benzo[h]pyrano[2,3-f]cinnolin-8-ones March 24, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00173D, PaperAlexander V. Migulin, Constantine V. Milyutin, Andrey N. KomogortsevIn this study, we report the first synthesis of allomaltol-substituted pyridazines and investigate their photochemical behavior.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Alexander V. Migulin
- Water-soluble squaramide functionalised peptides for sulfate recognition in aqueous media March 23, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00302H, PaperNikki A. Tzioumis, Katrina A. JolliffeFlexible peptidic receptors selectively bind sulfate ions in highly competitive aqueous mixtures through a combination of side chain and backbone hydrogen bonding interactions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Nikki A. Tzioumis
- Electrochemical direct site-selective selenation of carbazoles March 27, 2026
