RSC – Org. Chem. Front. latest articles- Allylic alcohols in borrowing hydrogen catalysis: from simple substrates to complex molecules April 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00148C, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michaël Vaglio-Pret, Mattéo Favre, Milly Ogden, amelie kochem, Adrien QuintardBorrowing hydrogen reactions are among the greenest approaches for creating complex molecules from simple materials. The most established borrowing hydrogen transformations are the […]Michaël Vaglio-Pret
- Photocatalytic Precision Editing of Amino Acid Residues: Advances, Mechanisms, and Future Directions April 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00346J, Review ArticleChengyang Ju, Ruiping Han, Jun Li, Teck Peng Loh, Peizhong XieVisible-light photoredox catalysis has emerged as a powerful platform to address longstanding challenges in the chemoselective modification of canonical amino acid residues within complex peptide and protein architectures. This review...The content of this RSS Feed (c) The […]Chengyang Ju
- Unraveling the mechanism and probing the origins of stereocontrol in cobalt-catalyzed carboamination reaction April 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00119J, Research ArticleYu-Nuo Wang, Cai Saibo, Yang WangIn the present study, the potential reaction mechanism for the cobalt-catalyzed carboamination of phenoxyacetamide with butyl acrylate was investigated using density functional theory (DFT) calculations. The computed energy profile indicates...The content of this RSS Feed (c) The Royal Society of ChemistryYu-Nuo Wang
- Electrochemical Vicinal Dichlorination and Dibromination of Unactivated Alkenes Using TMSX as the Halogen Source April 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00047A, Research ArticleZhi-Wang Pan, Ziyan Zou, Leyang Luo, Xiang Liu, Shang-Shi Zhang, Pengju FengAn environmentally friendly electrochemical method for vicinal dichlorination of unactivated alkenes has been developed using TMSCl as a chlorine source, facilitated by Et₄NI-mediated electrophilic addition under undivided electrolytic conditions. This...The content of this RSS Feed (c) […]Zhi-Wang Pan
- NIS-mediated, light-promoted intramolecular C-N cascade enables rapid access to benzo[4,5]indolo[3,2-c]isoquinolines and their photocatalytic applications April 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00126B, Research ArticleWan Wang, Chen Chen, Shuaichao Wei, Yulin Luo, Bo Han, Peibin Ma, Wei Huang, Gu ZhanA metal-and base-free, N-iodosuccinimide-mediated, light-promoted intramolecular cascade reaction has been developed for the rapid construction of benzo [4,5]indolo [3,2-c]isoquinolines. This transformation proceeds through two sequential intramolecular C-N bond-forming events under...The content of […]Wan Wang
- Biphenylene-based all-carbon analogues of dithienylethene photoswitches April 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00261G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Barnabás Zsignár-Nagy, Attila Kunfi, Bence Pál, Péter J Mayer, Gábor LondonWe report the exploration of novel diarylethene photoswitches constructed through the successive incorporation of the biphenylene ring system at key structural positions. […]Barnabás Zsignár-Nagy
- Redox-Neutral Assembly of Diheteroarylalkanes via Transient Directing Group-Enabled C-H Methylenation March 31, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00215C, Research ArticleXuemeng Wang, Liqing Xu, Kexin Ma, Yiyan Hong, Chuan Fu, Kai Tan, Dong WangWe report transition-metal-free homocoupling of quinolines and cross-coupling between quinolines and indoles via regioselective C(sp²)–H methylenation using Eschenmoser’s salt, providing direct access to two classes of diheteroarylalkanes. Mechanistic studies unveil...The content of this RSS […]Xuemeng Wang
- Enabling C–C bond-forming strategies for tailored derivatisation of heptazine frameworks March 30, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00267F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aurélien Huet, Benjamin Louis, Rana Deeba, Ahmed Ait Khouya, Yves Chenavier, Renaud Demadrille, Jacques Pécaut, Lionel Dubois, Julie AndrezHerein we report previously inaccessible functionalisation by C–C coupling reactions enabling the derivatisation of […]Aurélien Huet
- Unraveling ligand effect on enantio- and chemoselectivity in iridium-catalyzed ether-directed C(sp³)-H borylation of cyclopropanes: A computational study March 30, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00246C, Research ArticleGenping Huang, Xueyuan YanThe iridium-catalyzed ether-directed C(sp³)-H borylation of cyclopropanes represents a rare example of the borylation of the strained cycloalkanes. In this study, density functional theory calculations were conducted to elucidate the...The content of this RSS Feed (c) The Royal Society of ChemistryGenping Huang
- Access to α-Carbonyl Vinyl Sulfoxonium Ylides via Tandem Rearrangement-Addition of Cyclic Ethynylethylene Carbonates March 30, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00280C, Research ArticleSongtao Li, Yaping Tang, Rou Wang, Shengbiao Tang, Lin Qiu, Jiangtao SunWe report here a copper-catalyzed reaction of sulfoxonium ylides with cyclic ethynylethylene carbonates, enabling efficient access to highly functionalized α-carbonyl vinyl sulfoxonium ylides. This transformation proceeds via nucleophilic addition of...The content of this RSS Feed (c) […]Songtao Li
- A polyaromatic dumbbell-based micelle capable of binding large dyes under organic solvent-rich conditions March 30, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00227G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lorenzo Catti, Aguri Sugawara, Kazuki Toyama, Michito YoshizawaA dumbbell-shaped amphiphile assembles into a spherical polyaromatic micelle in water. Binding of organic and metal–organic dyes by the micelle yields host–guest composites with very […]Lorenzo Catti
- Carbon-Carbon to Boron-Nitrogen isosterism enables to switch toward fused 3D/2D magnetically aromatic systems March 29, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00257A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jordi Poater, Zahra NooriThe realization of genuine 3D/2D aromatic systems through fusion of BN/CC isosteric azaborines with carborane clusters has been systematically examined using magnetic response analysis. Current density maps, bond current […]Jordi Poater
- Carbon Isotope Exchange and Transfer Reactions involving CO2 March 29, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00133E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Grace Beaver, Katherine Elizabeth Marris, Daniel Ryder-Mahoney, Dimitrios Ioannis Tzaras, Ryan Ashley Bragg, Charles S Elmore, Gregory J. P. PerryCarboxylation reactions are fundamental transformations in organic chemistry, enabling the synthesis of diverse […]Grace Beaver
- Divergent Synthesis of Planar/Central-Chiral [n]Metacyclophanes by Asymmetric Acylation March 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00146G, Research ArticleZiyang Wang, Tingting Du, Haisong Xu, Yidan Sun, Xin LiAcquisition of a single enantiomeric configuration for planar-chiral [n]metacyclophanes, has persistently posed a formidable challenge. Herein, we report the stereodivergent synthesis of planar/central-chiral [n]metacyclophanes through chiral phosphoric acid-catalyzed reactions of...The content of this RSS Feed (c) The Royal […]Ziyang Wang
- Carbon dioxide as a methylene donor: modular synthesis of 3-aminomethyl chromones via a reductive tandem reaction † March 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00205F, Research ArticleYubing Zhou, Zhongrong Xu, Wei Li, Yimei Zeng, Wenxin Jiang, Jie-Ping Wan, Huanfeng Jiang, Chaorong QiA reductive tandem protocol that harnesses CO₂ as a methylene source is reported, enabling direct and modular assembly of biologically relevant 3-aminomethyl chromones from simple o-hydroxyaryl enaminones and amines. The...The content of […]Yubing Zhou
- DFT and machine learning insights into Ru(II) complex-catalyzed transfer hydrogenation March 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00178E, Research ArticleGui-Xiang Zhou, Cheng HouDFT and machine learning reveal the favorable metal–ligand cooperative mechanism in Ru(II)-catalyzed transfer hydrogenation and identify key descriptors for rational catalyst design.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Gui-Xiang Zhou
- Efficient Access to 5-Acylated Benzoxasilepines Enabled by NHC/Pd Cooperative Catalysis March 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00100A, Research ArticleLala Wang, Jixing Li, Ziye Cheng, Tingting Li, Huimin Xia, Shi-Chao RenThe termination of the endo-selective cyclization of 2-vinylphenol-derived iodomethylsilyl ether has been limited to hydrogen atom abstraction or transition metal-induced β-hydride elimination, affording non-substituted benzoxasilepines. Herein, we report the efficient...The content of this RSS Feed (c) […]Lala Wang
- Visible-light-driven radical cascade cyclization of 4-(N-alkyl-N-acrylamido)coumarins: access to difluoroalkylated 4,5-fused coumarins and coumarin[4,3-b]pyridinones March 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00192K, Research ArticleJin-Wei Yuan, Shi-Long Zhang, Xin-Ya Wang, Meng Yan, Yong-Mei Xiao, Dong-Hui Wei, Ling-Bo QuAn efficient and practical visible-light-driven cascade difluoroalkylation/cyclization of 4-acrylaminocoumarins has been developed using readily accessible [Ph3PCF2H]+Br− as the difluoroalkyl radical precursor.To cite this article before page numbers are assigned, use the DOI form of […]Jin-Wei Yuan
- Origin of Enantioselectivity in Copper-Catalyzed Aziridination of Enol Silyl Ethers: A Comprehensive DFT Study March 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00231E, Research ArticleJia-Long Wu, Yuchen Yang, Sheng-Ye Zhang, Xu Liu, Teng Sun, Yanan Zhao, Lijia WangChiral 1,2-amino alcohols are indispensable structural motifs in organic synthesis and pharmaceutical development, with the synthesis of chiral aziridine intermediates being a crucial step. Although experimental data indicate that the...The content of this RSS […]Jia-Long Wu
- Lewis base/alkali metal halide co-catalyzed allylic alkylation of gem-diborylalkanes with MBH carbonates for the construction of tert-alkylboronic esters March 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00181E, Research ArticleZhen-Xu Yang, Bing-Xia Yan, Lei Shi, Li-Dong Gong, Zhi-Shi YeAn efficient Lewis base/alkali metal halide co-catalyzed allylic alkylation of gem-diborylalkanes was developed, delivering tertiary and secondary alkylboronic esters in moderate to excellent yields.To cite this article before page numbers are assigned, use the DOI form of citation […]Zhen-Xu Yang
- Allylic alcohols in borrowing hydrogen catalysis: from simple substrates to complex molecules April 2, 2026
