RSC – Org. Chem. Front. latest articles- N-confused oxahexaphyrin: oxidative furan ring-opening and fusion triggered chirality September 17, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01104C, Research ArticleGaojie Zhu, Zimei Ma, Che Yang, Feng Sha, Glib Baryshnikov, Bin Zhu, Mingbo Zhou, Chengjie Li, Hans Ågren, Jianxin Song, Shijun Li, Qizhao Li, Yongshu XieOxidative ring-closure of N-confused hexapyrrane and thiahexapyrrane followed by oxidative opening of the pyrrole and thiophene rings has been shown to be […]Gaojie Zhu
- A novel member of a benzo-annulated oxocarbon family September 17, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01058F, Research ArticleAnna S. Rumyantseva, Konstantin Lyssenko, Tatiana V. MagdesievaAn unusual reactivity channel of semisquaraines is disclosed, yielding a novel type of oxocarbon derivative via facile synthetic procedure. The compound exhibits extremely rare “double” redox-ambipolarity (strong stabilization of both...The content of this RSS Feed (c) The Royal Society of […]Anna S. Rumyantseva
- Copper-catalyzed HFIP-promoted para-selective allylation of phenols via C–C bond activation of gem-difluorinated cyclopropanes September 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01197C, Research ArticleXu Xu, Yilian Song, Wenhao Xu, Xiaoping Wang, Haitao Chen, Yingsheng ZhaoThis study presents a copper-catalyzed para-selective fluoroallylation of unprotected phenols achieved through a ring-opening cross-coupling approach.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Xu Xu
- Synthesis of non-symmetric ortho-functionalized azoarenes through arylation of arylazo sulfones September 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00932D, Research ArticleRayhane Hammami, Victor Flon, Morgane Sanselme, Julien Legros, Isabelle Chataigner, Laetitia Chausset BoissarieA novel protocol for the arylation of arylazo sulfones with organomagnesiums for accessing non-symmetric ortho-functionalized azoarenes has been succesfully developped. Bench-stable substituted arylazo sulfones, which serve as masked electrophilic diazo...The content of this RSS Feed […]Rayhane Hammami
- Monodentate Halogen Bond Activation of Aziridines in Formal [3+2] Cycloadditions September 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01119A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mattis Damrath, Boris Johannes NachtsheimThe ring opening of aziridines to produce various N-heterocycles traditionally requires strong Lewis acids or transition metal catalysts, with non-covalent organocatalytic approaches remaining largely unexplored. Herein, we demonstrate […]Mattis Damrath
- Rhodium-Catalyzed Cycloaddition of Bicyclo[1.1.0]butanes with N,N’-Cyclic Azomethine Imines: En Route to Fused Diaza-3D Scaffolds September 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01147G, Research ArticleTianlei Du, Qiujie Qin, Jin Li, Yuting Shen, Zixi Wang, Kun Yin, Xinyao Li, Jian Li, Zijun ZhouThe construction of aza-3D frameworks has emerged as a pivotal strategy in drug discovery, owing to their ability to mimic heteroarene bioisosteres. In this study, we introduce a novel strategy...The […]Tianlei Du
- Gold-catalyzed azidation with TMSN3 and mechanistic studies September 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01091H, Research ArticleJiawen Wu, Siying Zhao, Xiu-Tian-Feng E, Junfeng Wang, Zhonghua XiaThe growing demand for aryl azides in diverse fields has spurred significant advances in their synthetic methodologies. Herein, we report a gold-catalyzed C–N₃ cross-coupling reaction enabled by ligand-supported Au(I)/Au(III) redox...The content of this RSS Feed (c) The Royal […]Jiawen Wu
- Nitrosobenzenes as a stepping stone for the development of transition metal and metal-free organic transformations: a comprehensive review September 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00842E, Review ArticleNandini R., Ramesh B. DateerNitrosobenzenes are versatile intermediates in organic synthesis. Their NO group on an aromatic ring gives them both electrophilic and nucleophilic character, enabling diverse reactivity in both metal-catalyzed and metal-free transformations.To cite this article before page numbers are assigned, use the DOI form of […]Nandini R.
- Nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo compounds as N-terminal electrophiles: direct access to novel functionalized hydrazones September 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00885A, Research ArticleVarun Anand, Ruchir Kant, Namrata RastogiThe nucleophilic addition of sulfoxonium ylides to hypervalent Iodine diazo reagents as N-terminal electrophiles leads to highly functionalized hydrazones. The operational simplicity, wide scope, high product yields and mild conditions are notable features of the methodology.To cite this article before page numbers […]Varun Anand
- Regioselective Formation of Naphtho[2,1-b]selenophenes via Cascade Cyclization of 1,3-Diynylpropargyl Alcohols Promoted by Iron(III) Chloride and Diorganyl Diselenides September 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01195G, Research ArticlePedro Pauletto, Davi Back, Cristina Nogueira, Gilson ZeniThis manuscript reports a selective diorganyl diselenide/iron(III)-promoted strategy for the synthesis of selenium-containing heterocycles, specifically naphtho[2,1-b]selenophene derivatives, via cascade cyclization reactions.Using 1,3diynylpropargyl alcohols as key substrates and diorganyl diselenides as...The content of this RSS Feed (c) The Royal Society of […]Pedro Pauletto
- Mechanistic and machine learning insights into borrowing hydrogen reactions catalyzed by transition metal complexes with N-heterocyclic ligands September 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01139F, Research ArticleHui-Qi Mo, Cheng HouDFT and machine learning uncover the N2-assisted outer-sphere pathway as the most favorable in pyrazole-based BH catalysis, with the HOMO level, dipole moment, and steric effects identified as key performance-determining factors.To cite this article before page numbers are assigned, use the DOI form of […]Hui-Qi Mo
- Alkyne-inserted tetraphenylethylene derivatives: enhanced aggregation-induced emission via intramolecular and intermolecular interactions September 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01158B, Research ArticleYi-Yun Zhu, Wen-Hao Li, Yan-Qi Fan, Hao-Chen Lu, Donghui Wei, Xuenian ChenSolid-state luminescence is often hindered by aggregation-caused quenching (ACQ), prompting the search for efficient aggregation-induced emission (AIE) materials.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Yi-Yun Zhu
- Cu-Catalyzed Cyanoalkyl-Alkynylation of gem-Disubstituted Alkenes to Construct All-Carbon Quaternary Center September 10, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01138H, Research ArticleYuhang Luo, Xiangxiang Li, Xinjie Zhao, Baomin Yang, Yubo Wei, Guiping QinA copper-catalyzed cyanoalkyl-alkynylation of gem-disubstituted alkenes for the construction of the alkynyl all-carbon quaternary center is reported herein. This protocol enables the efficient synthesis of various cyano compounds with an...The content of this RSS Feed (c) […]Yuhang Luo
- 1,6-Hydrosulfonylation of p-quinone methides enabled via strain-release-/aromaticity-driven alkyl radical generation and SO2-capture: synthesis and antiproliferative studies of sulfonylated diarylmethanes September 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00981B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dipun Kumar Penthi, Tonish Kumar Sahu, Rahimuddin Khan, Shanti Gopal Patra, Tabrez KhanA visible light photoredox catalyzed 1,6-hydrosulfonylation of p-QMs has been demonstrated for the efficient synthesis of S(VI)-diarylmethanes via the incorporation […]Dipun Kumar Penthi
- Electrochemical water activation for the oxidative cleavage of alkenes September 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00944H, Research ArticleNing Zhang, Hui Zhou, Guojuan Liang, Gaochen Liu, Xing Liu, Pengfei Zhou, Dong Zhang, Jing ZhouElectrochemically activated water mediates sustainable oxidative cleavage of both activated and unactivated alkenes without external oxidants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Ning Zhang
- AgOTf-promoted transetherification of p-methoxybenzyl ethers with allyl and benzyl bromides September 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00945F, Research ArticleYufan Yang, Dongyang Jiang, Xuan Li, Juxi Wang, Lu Gao, Wanshu Wang, Zhenlei SongAn AgOTf-promoted transetherification of p-methoxybenzyl ethers with allyl and benzyl bromides is reported. It features an unusual C–O/C–Br σ-bond metathesis via an oxonium intermediate, distinct from typical C–O/O–H or C–O/C–O σ-bond metathesis.To cite this article before […]Yufan Yang
- Highly stereoselective synthesis of N-sulfonyl amidines with calcium carbide as an acetylene source September 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01010A, Research ArticleRui An, Weihao Cui, Peiming Gu, Meng-Xue WeiA practical and convenient approach for the highly stereoselective synthesis of N-sulfonyl amidines via a one-pot multi-component cascade reaction of sulfonyl azides, amines, water, and calcium carbide as an acetylene source has been developed.To cite this article before page numbers […]Rui An
- Electrophilic insertion and ring growth in 1,2,5-azadiborolidines: theoretical evidence for boron-driven expansion September 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01081K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Victor A. Lucas-Rosales, Miguel A. Vázquez, Gabriel Merino, Albert Poater, J. Oscar C. Jiménez-HallaDFT calculations predict endocyclic CO insertion in 1,2,5-azadiborolidines followed by dimerization and double [1,2]-migration, defining a fourth class of […]Victor A. Lucas-Rosales
- Streamlined synthesis of meta- or para-substituted triphenylamine[3]arenes and their hierarchical assembly into polyhedral cages September 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01089F, Research ArticleWangjian Fang, Xin Li, Audrey Nathania Johan, Yimin Zhang, Guoqiang Jiang, Andrew C.-H. SueAn efficient synthesis of meta- or para-substituted triphenylamine[3]arenes is achieved using bromo- or ester-substituted triphenylamine monomers via a BF3·Et2O-catalysed one-pot Friedel–Crafts cyclization with paraformaldehyde.To cite this article before page numbers are assigned, use the […]Wangjian Fang
- Facile N-directed Ru-catalyzed C(3)–H acylation of heterocyclopentadienes with acyl chlorides September 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00965K, Research ArticleKonstantin E. Shepelenko, Irina G. Gnatiuk, Andrey A. Aleksandrov, Mikhayl E. Minyaev, Victor M. Chernyshev, Valentine P. AnanikovA Ru-catalyzed C3–H acylation of 2-substituted heterocyclopentadienes with acyl chlorides, compatible with various N-directing groups. The reaction proceeds via rate-limiting C–H activation step, facilitated by in situ-generated carboxylate.To cite this […]Konstantin E. Shepelenko
- N-confused oxahexaphyrin: oxidative furan ring-opening and fusion triggered chirality September 17, 2025
