RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Rational Design of an Acridine-derived Click Chemistry-based Artificial Metallo-Nuclease June 14, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00097E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Oliver Gould, Alex Gibney, Rebecca Lynn, Simon Poole, Brionna McGorman, Andrew KellettArtificial metallo-nucleases (AMNs) are metal complexes capable of cleaving nucleic acids and represent a promising therapeutic class. We recently established that copper(I)-catalysed […]
  Oliver Gould
• DNA Origami–Based Drug Delivery and Cell Manipulation: Toward Intelligent Nanomedicine June 14, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00026F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuki SuzukiDNA origami has emerged as a versatile platform for constructing nanoscale architectures with precise shape programmability, molecular-level addressability, and dynamic structural reconfigurability. Since its introduction, DNA origami has evolved from...The content […]
  Yuki Suzuki
• Stabilized thioamide peptide agonists of the neuropeptide Y type 2 receptor for targeted cancer imaging June 11, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00042H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hoang Anh T. Phan, Yanan Chang, Taylor M. Barrett, Kristen E. Fiore, Daniel Y. Zhang, Ethan J. Grove, E. James PeterssonA fluorescent cyclic thioamide peptide has a serum half life over 8 hours […]
  Hoang Anh T. Phan
• Structure, Characterisation and Application of an Unspecific Peroxygenase from Daldinia childiae June 10, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00141F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander McKenzie, Claudia Clark, Katy A. S. Cornish, Jiacheng Li, Jack Domenech, Benjamin Melling, Miles Ralston, Jared Cartwright, Nicholas P Mulholland, William Paul Unsworth, Gideon GroganUnspecific Peroxygenases (UPOs) have emerged as useful biocatalysts […]
  Alexander McKenzie
• De novo grafted coiled-coil peptides as p53/hDM2 inhibitors June 10, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00063K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Freya Spain, Diana Gimenez, Amanda M. Acevedo-Jake, Bram Mylemans, Nikolas J. Brooks, Boguslawa Korona, Danny T. Huang, Thomas A. Edwards, Aneika C. Leney, Laura Itzhaki, Derek N. Woolfson, Andrew J. WilsonDysregulation of protein–protein […]
  Freya Spain
• Introducing azobenzenes as solid phase peptide synthesis linkers June 7, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00028B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Connor B. Śmieja, Lizun Xin, Tianhui Tang, Ryan Tan, Martin Lee, Alison N. HulmeThe ̲̲umarin-̲oaded ̲̲obenzene (COLAZ) linker for SPPS produces peptides with an integrated fluorescent label. Upon its biocompatible cleavage with dithionite […]
  Connor B. Śmieja
• A non-canonical function of RNF8 opposes TRAF6-mediated stabilization of HIF1α June 7, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00209E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Larissa Ringelstetter, Elisabeth Mersdorf-Weber, Kenji Schorpp, Kamyar HadianRNF8 antagonizes TRAF6-mediated stabilization of HIF1α via a non-canonical FHA-domain interaction, revealing a previously unrecognized mechanism that modulates hypoxia-induced signaling and downstream cellular responses.To cite this […]
  Larissa Ringelstetter
• Thio-modification effects on mRNA translation using a PureCap-based capping method June 4, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00047A, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zheyu Meng, Yiwei Liu, Yuko Nakashima, Masahito Inagaki, Seigo Kimura, Yukari Kondo, Fumitaka Hashiya, Naoko Abe, Noriko Saito-Tarashima, Noriaki Minakawa, Yasuaki Kimura, Hiroshi AbeSulfur-modified PureCap analogs enable HPLC purification of the corresponding thio-modified […]
  Zheyu Meng
• The γ-Secretase Complex: From Discovery to Therapeutic Target June 4, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00022C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shweta R. Malvankar, Michael Scott Wolfeγ-Secretase is an intricate intramembrane aspartyl protease that cleaves within the transmembrane domain of ~150 substrates and considered the 'proteasome of membrane'. This enzyme consists of four […]
  Shweta R. Malvankar
• Methylation of DNA duplexes regulates cGAS-mediated innate immune activation via condensate formation June 3, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00059B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kunihiko Morihiro, Manami Baba, Moeko Yamada, Akimitsu OkamotoSystematic comparison of DNA chemical modifications identifies 2′-OMe-modification as a potent enhancer of cGAS-mediated condensate formation and innate immune signaling.To cite this article before page numbers […]
  Kunihiko Morihiro