RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein July 9, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00141B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tommaso Garfagnini, Zvi Hayouka, Assaf FriedlerAggregation of dysfunctional proteins can lead to a variety of diseases including cancer. We have previously developed chaperone-derived peptides that inhibit aggregation of the cancer-related L106R mutant of […]
  Tommaso Garfagnini
• Unravelling Structure-function Interactions Between Fluorinated Heparan Sulfate Mimetics and Signaling Proteins July 9, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00174A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Virendrasinh Mahida, Rakesh Raigawali, Paula González, Ana Gimeno, Shani Leviatan Ben-Arye, Saurabh Anand, Sandhya Mardhekar, Jesus Jimenez-Barbero, vered Padler-karavani, Raghavendra V KikkeriFluorinated carbohydrates are emerging scaffolds in glycobiology, enabling the elucidation of the […]
  Virendrasinh Mahida
• Outstanding Reviewers for RSC Chemical Biology in 2024 July 7, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB90026C, Editorial Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.We would like to take this opportunity to highlight the Outstanding Reviewers for RSC Chemical Biology in 2024, as selected by the editorial team for their significant contribution to the journal.To cite this […]
• Structure-Guided Engineering of a Polyphosphate Kinase 2 Class III from an Erysipelotrichaceae Bacterium to Produce Base-Modified Purine Nucleotides July 6, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00108K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel M. Mitton-Fry, René Rasche, Ann-Marie Lawrence-Dörner, Jannik Eschenbach, Aileen Tekath, Andrea Rentmeister, Daniel Kümmel, Nicolas Vincent CornelissenNucleobase-modified nucleoside-5′-triphosphates (NTPs) are important building blocks for the enzymatic synthesis of non-coding RNAs and mRNAs […]
  Rachel M. Mitton-Fry
• Signals from the Sea: Structural peculiarity of Lipid A and Weak Immunostimulatory Lipopolysaccharide from Rheinheimera japonica July 6, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00134J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stefania De Chiara, Francesca Olmeo, Emanuela Andretta, Luca De Simone Carone, Marcello Mercogliano, Vlada Belova, Lyudmila Romanenko, Maxim Kokoulin, Alba Silipo, Antonio Molinaro, Flaviana Di LorenzoLipopolysaccharides (LPSs) isolated from marine bacteria represent a […]
  Stefania De Chiara
• Exploring the immunoproteasome's substrate preferences for improved hydrolysis and selectivity July 6, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00114E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Christine S. Muli, Cody A. Loy, Darci J. TraderThe proteasome is an integral macromolecular machine responsible for regulated protein degradation, and its barrel-like core particle (CP) hydrolyzes protein substrates into peptide fragments.To cite […]
  Christine S. Muli
• A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells July 2, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00045A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ben Tiet, Sha Zhu, Xi Chen, Nadia Anastasi, Nicholas W. See, Matthew C. Deen, Eva Harde, David J. VocadloLysoRF-GBA is a dual-functional fluorescent substrate for quantifying β-glucocerebrosidase (GCase) activity within cells. Distinct fluorescence […]
  Ben Tiet
• Correction: Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms July 2, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB90030A, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Monica S. Hensley, David Hutchings, Aldelrahman Ismail, Micaela Rayne Geborkoff, Thomas Werner, Marina TanasovaTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]
  Monica S. Hensley
• A biparatopic HER2-targeting ADC constructed via site-specific glycan conjugation exhibits superior stability, safety, and efficacy June 24, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00096C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Qi Xue, Jianjian Peng, Wenying Dai, Qingsong Wu, Jinbiao Jiao, Yudi Hu, Wanxing Sha, Yang Yang, Wenhao Yu, Siyang Liu, Ting Xu, Jie P. LiSite-specific glycan conjugation enables a stable and efficacious biparatopic […]
  Qi Xue
• The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples June 22, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00079C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Olga Predeina, Misha Atkinson, Oliver Wissett, Montader Ali, Cristina Visentin, Stefano Ricagno, Anthony H. Keeble, Mark R. Howarth, Pietro SormanniA less than 24-hour workflow with little hands-on time delivers quantitative protein binding kinetic […]
  Olga Predeina