RSC – RSC Chem. Biol. latest articles- Development of PROTACs for targeted degradation of oncogenic TRK fusions March 18, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00008H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Saurav Kumar, Jiewei Jiang, Mia S. Donald-Paladino, Joy Chen, Andrea Gutierrez, Alexander J. Federation, Frank Szulzewsky, Eric C. Holland, Fleur Ferguson, Behnam NabetChromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRKs) […]Saurav Kumar
- High-throughput discovery and characterisation of pentafluorobenzene sulfonamide modifiers of Aurora A kinase March 16, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00290G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Julian Chesti, Jennifer A. Miles, Lawrence J. Collins, Hamish A. McCallum, Martina Foglizzo, Mohd Syed Ahangar, Elton Zeqiraj, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam NelsonCovalent modification, by substitution of pentafluorobenzene […]Julian Chesti
- Post-translational modifications of silk proteins March 5, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00012F, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kota Nomura, Keiji NumataPost-translational modifications (PTMs) endow silk proteins with chemical diversity that governs their higher-order assembly, hydration, and covalent connectivity.To cite this article before page numbers are assigned, use the DOI […]Kota Nomura
- Comparative analysis of alkyne- and desthiobiotinylated photoaffinity probes for chemotranscriptomic profiling March 4, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00030D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daphne A. L. van den Homberg, Georgia Poulladofonou, Aurelia Dekens, Willem A. VelemaThe suitability of desthiobiotin and alkyne modified Ribocil photoaffinity probes for chemotranscriptomic profiling were compared. Desthiobiotin appears to unselectively interact with […]Daphne A. L. van den Homberg
- Integration of palladium-catalyzed C–N coupling into self-encoded libraries for accelerated hit discovery March 3, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00303B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Edith van der Nol, Zhenshuo Luo, Qing Qing Gao, Nils Alexander Haupt, Sebastian Böcker, Sebastian PomplunWe expanded the self-encoded library (SEL) platform via C–N cross-couplings, testing 170+ building blocks and generating a 25.725-member […]Edith van der Nol
- Photoclickable Halotag ligands for spatiotemporal multiplexed protein labeling on living cells March 3, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00017G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Franziska Walterspiel, Begoña Ugarte-Uribe, Stefan Terjung, Alex Cabrera, Arif Ul Maula Khan, Claire DeoA novel photoclickable HaloTag ligand enables multicolor spatiotemporal labeling of proteins on the surface of living cells.To cite this article […]Franziska Walterspiel
- Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection February 26, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00242G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isabella E. Pellizzari-Delano, Trinity H. Tooley, Debanjana Mondal, Keya Jani, Carla E. Gallardo-Flores, Che C. ColpittsBroad spectrum host-targeting antivirals are critical to respond rapidly to newly emerging RNA viruses.To cite this article before […]Isabella E. Pellizzari-Delano
- Structure and characterisation of CMP-Kdn synthetase from the haptophyte microalgae Prymnesium parvum February 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00285K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Claire Morley, Alexandra J. Munro-Clark, Ben A. Wagstaff, Irina Ivanova, Evgenia Dubinskaya, Ava Rostock, Mary Ortmayer, Colin W. Levy, Robert A. FieldStructural characterisation of a Kdn specific sialic acid synthetase, which can be […]Claire Morley
- Discovery of natural products that modulate signaling in patient-derived cells February 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00203F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Joseph A. Balsamo, Hannah L. Thirman, Kathryn E. Penton, Jordan T. Froese, Benjamin J. Reisman, Sierra M. Lima, Madeline J. Grider-Hayes, Chad R. Potts, Jonathan M. Irish, P. Brent Ferrell, Brian O. BachmannMany […]Joseph A. Balsamo
- Folded-state compatibility and unfolded-state constraint govern staple-based stabilization: guidelines from a coiled-coil model February 24, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00326A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samantha C. Hatfield, Alexa N. Mattingley, Kayla K. Sujeta, Logan D. Humphrey, Taylor Crook, Hiram Aranda, Christian H. Freckleton, Joseph V. Clayson, Chase Renstrom, Joshua L. PricePeptide stapling has emerged as a powerful […]Samantha C. Hatfield
- Development of PROTACs for targeted degradation of oncogenic TRK fusions March 18, 2026
