RSC – RSC Chem. Biol. latest articles- A biparatopic HER2-targeting ADC constructed via site-specific glycan conjugation exhibits superior stability, safety, and efficacy June 24, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00096C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Qi Xue, Jianjian Peng, Wenying Dai, Qingsong Wu, Jinbiao Jiao, Yudi Hu, Wanxing Sha, Yang Yang, Wenhao Yu, Siyang Liu, Ting Xu, Jie P. LiSite-specific glycan conjugation enables a stable and efficacious biparatopic […]Qi Xue
- The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples June 22, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00079C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Olga Predeina, Misha Atkinson, Oliver Wissett, Montader Ali, Cristina Visentin, Stefano Ricagno, Anthony H. Keeble, Pietro Sormanni, Mark R. HowarthAccurate measurements of binding kinetics, encompassing equilibrium dissociation constant (KD), association rate (kon), and […]Olga Predeina
- Visualizing stress granule dynamics with an RNA guanine quadruplex targeted ruthenium(II) peptide conjugate June 18, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00008D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rhianne C. Curley, Lorcan Holden, Tia E. KeyesA cell permeable Ru(II) polypyridyl complex conjugated to G4 binding domain peptide from RNA helicase associated with AU-rich element (RHAU) was developed as a tool to […]Rhianne C. Curley
- Regulation of bacterial phosphorelay systems June 18, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00016E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniel M. Foulkes, Daniel M. Cooper, Catherine Westland, Dominic P. ByrneThis review examines the regulatory mechanisms governing the catalytic activities of diverse classes of bacterial kinases and evaluates their viability as targets […]Daniel M. Foulkes
- Advances in programmable DNA nanostructures enabling stimuli-responsive drug delivery and multimodal biosensing June 16, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00057B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yao Hong, Wenyue Ma, Meixia Wang, Hong-Hui WangProgrammable DNA nanostructures enable stimuli-responsive drug delivery and multimodal biosensing. This review highlights their modular design, stability, and precision in disease-targeted therapy and early cancer […]Yao Hong
- Correction: Proximity-induced SuFEx increases the potency of cytosolic nucleotidase inhibitors and reveals a rare example of covalently targeted histidine June 11, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB90025E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mikolaj Chrominski, Marcin Warminski, Mateusz Kozarski, Dorota Kubacka, Joanna Panecka-Hofman, Tomasz Spiewla, Mikolaj Zmudzinski, Jacek Jemielity, Joanna KowalskaTo cite this article before page numbers are assigned, use the DOI form of citation above.The […]Mikolaj Chrominski
- Quantitative neuropeptide analysis by mass spectrometry: advancing methodologies for biological discovery June 11, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00082C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Angel Erbey Ibarra, Wenxin Wu, Haoran Zhang, Lingjun LiNeuropeptides are critical endogenous signaling molecules involved in a wide range of biological processes. They display high complexity that requires advanced analytical strategies for […]Angel Erbey Ibarra
- Emerging gut microbial glycoside hydrolase inhibitors June 10, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00050E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mark E. Kowalewski, Matthew R. RedinboGlycoside hydrolase inhibitors are emerging as valuable tools to study gut microbial enzymes that modulate host physiology and disease by degrading dietary, drug-related, and host-derived glycans.To cite […]Mark E. Kowalewski
- Regulation of carcinogenesis through multiple zinc fingers in ZBTB20 June 8, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00088B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hyunyong Kim, Yunha Hwang, Jin Sung Cheong, Seung Jae LeeZBTB20 binds to the afp and foxO1 promoters, represses their transcription, and regulates hepatocarcinogenesis.To cite this article before page numbers are assigned, use the […]Hyunyong Kim
- Metal-mediated peptide processing. How copper and iron catalyze diverse peptide modifications such as amidation and crosslinking June 5, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00085H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ninian J. BlackburnPeptide processing is an important post-translational function that converts newly synthesized pro-peptides into their biologically active mature forms.To cite this article before page numbers are assigned, use the DOI form […]Ninian J. Blackburn
- A biparatopic HER2-targeting ADC constructed via site-specific glycan conjugation exhibits superior stability, safety, and efficacy June 24, 2025
