RSC – RSC Med. Chem. latest articles
- Development of Heterocyclic Derivatives as P-Glycoprotein Inhibitors Against Multidrug Resistance:Pharmacological Activities, Structure-activity Relationship and Target (2020-2024) August 25, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00609K, Review ArticleZhikun Yang, Yanhong Yang, Zimeng Huang, Yi Hua, Mahmoud Emam, Hong WangThe overexpression of P-glycoprotein (P-gp) has been recognized as a pivotal factor contributing to the emergence of multidrug resistance (MDR), a phenomenon that frequently limits the efficacy of chemotherapy and...The content of this RSS Feed (c) […]Zhikun Yang
- Multi-Targeted Azacoumarin–Cyanocinnamate Hybrids Induce G2/M Arrest and Apoptosis via Tubulin, and COX-2/VEGFR Modulation: insights from in vitro mechanistic basis and in vivo validation August 21, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00484E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manar A. El-Zend, Ibrahim El-Deen, Rawda M. Mansour, Tarek A. Yousef, Amal Abdullah Alrashidi, Essa M SaiedCancer remains a significant global health concern, with breast cancer ranking among the leading causes of […]Manar A. El-Zend
- Delivery strategies to improve the pharmacological efficacy of NRF2 modulators: A review August 21, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00571J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zerrin Sezgin-Bayindir, Matej Sova, Nilufer Yuksel, Luciano SasoThe NRF2/KEAP1 signaling pathway regulates the gene expression of numerous cytoprotective and detoxifying enzymes and is therefore essential for maintaining cellular redox homeostasis. Despite the […]Zerrin Sezgin-Bayindir
- Computationally guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines August 19, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00353A, Research ArticleGuntur Guntur, Duangkamol Gleeson, Mark Anderson, Nicole Mutter, Lauren Webster, Kevin D. Read, M. Paul GleesonCheminformatics-guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Guntur Guntur
- Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD⁺ co-factor binding August 18, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00144G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ricky Wirawan, Matthias Frei, Anna Heider, Niklas Papenkordt, Florian Friedrich, Thomas Wein, Manfred Jung, Michael Groll, eva huber, Franz BracherHuman sirtuin 2 (SIRT2) is an NAD+ dependant enzyme that has been linked […]Ricky Wirawan
- Indazole – An Emerging Privileged Scaffold: Synthesis and its Biological Significance August 18, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00336A, Review ArticleAnuradha Singampalli, Pardeep Kumar, Rani Bandela, Sri Mounika Bellapukonda, Srinivas Nanduri, Venkata Madhavi YaddanapudiNitrogen-containing molecules are an important class of heterocyclic compounds. Among these, indazole is one of the most important scaffolds with a broad scope because of its pharmaceutical and biological properties....The content of this RSS […]Anuradha Singampalli
- Polyethylene glycol incorporation to reduce the cytotoxicity associated with cationic cell-penetrating-peptide conjugation August 14, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00503E, Research ArticleNaoki Umezawa, Kazuma Arakawa, Maiko Kato, Yosuke Hisamatsu, Hirokazu Yagi, Chiharu Miyajima, Yasumichi InoueThe branched PEG unit minimizes the toxicity of cationic cell-penetrating peptide conjugates while preserving their biological functions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Naoki Umezawa
- Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design August 14, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00356C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Conrad Fischer, Jimmy Lu, Marco J. van Belkum, Sydney Demmon, Pu Chen, Chaoxiang Wang, Tayla J. Van Oers, Tess Lamer, M. Joanne Lemieux, John C. Vederas4 was confirmed as low nanomolar binder […]Conrad Fischer
- Benzo-ring modification on Malaria Box hit MMV008138: effects on antimalarial potency and microsomal stability August 14, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00439J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maryam Ghavami, Haibo Li, Lixuan Liu, Joshua H. Butler, Sha Ding, Grant J. Butschek, Reagan S. Haney, R. McAlister Council-Troche, R. Justin Grams, Emilio Merino, Jennifer M Davis, Maxim Totrov, Maria B. […]Maryam Ghavami
- Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors August 13, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00435G, Research ArticleShuyi Mu, Wenqiang Sun, Zehui Qi, Minghui Tong, Xuan Shi, Han Wang, Nian Liu, Pengkun Sun, Cunzheng Fan, Ningyuan Hu, Yixiang Sun, Haoyu Zhang, Zixuan Gao, Dongmei Zhao, Maosheng ChengSerine/threonine kinase PLK4, a critical regulator of centrosome duplication, is closely associated with tumorigenesis due to its role […]Shuyi Mu
- Development of Heterocyclic Derivatives as P-Glycoprotein Inhibitors Against Multidrug Resistance:Pharmacological Activities, Structure-activity Relationship and Target (2020-2024) August 25, 2025