RSC – RSC Med. Chem. latest articles- Discovery of GBA-16-24 as a highly potent, selective ATR inhibitor for the treatment of FLT3-mutated acute myeloid leukemia March 3, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01005E, Research ArticlePing Li, Haiyan Ren, Xinyan Lan, Junfei Li, Zhi Liu, Huashuo Liu, Zhijie Zheng, Tianyan Zeng, Peili Wang, Mingyang Sun, Lei Xu, Yanyan Zhang, Yu-Bo Zhou, Jia Li, Mingliang Wang, Kailong JiangAtaxia telangiectasia mutations and RAD3-related (ATR) kinase supports cancer cell survival via managing DNA damage or […]Ping Li
- Hypoxia-Triggered Dichloroacetate Delivery with Effective Reversal of Cancer Cell Reprogramming March 2, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00911A, Research Articlerensong sun, Lei Wang, ziang liu, Hao Wu, Wanwan Wang, Yang Wang, Xiao Qian, Engin AkkayaDichloroacetate (DCA) is a known inhibitor of pyruvate dehydrogenase kinase, which is part of the key enzyme complex in metabolic reprogramming of cancer cells. In this work, we structurally modified...The content of […]rensong sun
- Pharmacological Landscape of Carbolines: A Holistic View March 2, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00057F, Review Articleyao Zhag, Fule Wu, Muneeb Ur Rehman, Sihui LongNatural resources have served as a cornerstone for the discovery of innovative pharmaceutical compounds for millennia. Among the diverse natural compounds demonstrating significant pharmacological activities, carbolines cannot be overlooked. Carbolines...The content of this RSS Feed (c) The Royal Society […]yao Zhag
- New Series of Pentamidine-Based 1,2,3-Triazole-Diaryl-Hydrazones: Design, Synthesis, and Evaluation of Their Leishmanicidal Activity and Mechanism of Action Against Leishmania (L.) amazonensis February 27, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01174D, Research ArticlePatrícia F Espuri Sepini, Vanessa Gontijo, Laiane M Tavares, Leonardo M Souza, Thalles Henrique Souza, Dyecika S Couto, Juliana B Nunes, Catarina A Azevedo Ribeiro, Sara Mendonça Cravo, Bruno Zavan, Marina Amaral Alves, Hygor Marcos Ribeiro de Souza, Marisa Ionta, Maria Emília Sousa, Eduardo F Peloso, Marcos […]Patrícia F Espuri Sepini
- The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin February 27, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00841G, Research ArticleShaofen Zhou, Jingyan Wei, Shixin Li, Jingnan Qiu, Shuaiqi Ma, Jian HeSF-4 inhibits influenza virus infection and the excessive inflammatory response resulting from viral infection by inhibiting NF-κB activation and activating the Nrf2/HO-1 pathway.To cite this article before page numbers are assigned, use the DOI form of […]Shaofen Zhou
- Design, synthesis and biological evaluation novel 3,4-dihydro-2(1H)-quinoline-O-carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer’s disease February 27, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01138H, Research ArticleWenling Fu , Keren Wang, Hongsong Chen, Taoyi Liu, Xiaojuan Liu, Qishun Jin, Zhenghuai Tan, Wu Dong, Wenmin Liu, Zhi-Pei SangAlzheimer’s disease (AD) is an irreversible degenerative disorder of the brain, and there is no effective drug for it to date. Given its complex pathogenesis, the multi-target-directed […]Wenling Fu
- A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis via PPARγ regulation February 26, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01142F, Research ArticleShi-Ying Xu, Quan-Xing Liu, Yan Luo, Wu-He Wu, Qing Li, Shang-Gao Liao, Jun-Li Ao, Guo-Bo XuHalogenated pregnenolone derivative 20 exerts potent anti-HepG2 effects by inhibiting proliferation and inducing apoptosis through PPARγ modulation.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Shi-Ying Xu
- 1,3,4-Oxadiazole Derivatives: Targeting Multiple Bacterial Pathways February 25, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01139F, Review ArticlePankaj Gupta, Sangeeta Verma, Rakesh Narang, Bhupesh Sharma, Vikramjeet Singh, Sukhbir LalAntimicrobial resistance (AMR) has emerged as a major worldwide issue in the effective management of infectious diseases. This problem prompted researchers worldwide to develop new therapeutic agents that target both...The content of this RSS Feed (c) […]Pankaj Gupta
- Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential Human Toll-Like Receptor (TLR)2 Agonists: Design, Synthesis, and Structure-Activity Relationship Enabling the Switch from TLR2/1 to TLR2/6 Activation February 25, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01078K, Research ArticleMunugala Chandrakanth, Yoshikazu Honda Okubo, C. G. Arya, Deepak B Salunke, Nikolai Petrovsky, Janardhan BanothuToll-like receptor 2 (TLR2) acts as a pivotal family of pattern-recognition receptors that bridges innate and adaptive immunity through the detection of PAMPs and DAMPs. In pursuit of novel immunomodulators,...The content of this […]Munugala Chandrakanth
- Triclosan-Isatin Hybrids as Potent Anti-proliferative Agents Inducing S-Phase Arrest via DNA Gyrase Inhibition in Triple-Negative Breast Cancer February 24, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00013D, Research ArticleVipan Kumar, Shekhar Shekhar, Asif Raza, Sukhmanpreet Kaur, Amit Anand, Arun K. SharmaA series of 1H-1,2,3-triazole-tethered TCS–isatin hybrid compounds were synthesized and evaluated for their antiproliferative activity against triple-negative breast cancer (TNBC). These hybrids exhibited remarkable potency against MDA-MB-231 and MDA-MB-468 cell...The content of this RSS Feed […]Vipan Kumar
- Discovery of GBA-16-24 as a highly potent, selective ATR inhibitor for the treatment of FLT3-mutated acute myeloid leukemia March 3, 2026
