RSC – RSC Med. Chem. latest articles- Revealing deamidation and isoaspartate formation during peptide analysis, purification and storage by tandem mass spectrometry December 29, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01025J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.V. Erckes, L. Chamera Rendueles, A. Misiek, C. SteuerInterest in peptides and peptidomimetics continues to grow, particularly in the context of drug discovery and development. However, spontaneous chemical modifications such as deamidation […]V. Erckes
- Strategies to Inhibit Steroid Cytochrome P450 Enzymes to Benefit Human Health: Development of Steroid Ligands for P450s 17A1, 19A1, and 8B1 to Treat Cancer and Obesity December 29, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00954E, Review ArticleTu M. Ho, Francis YoshimotoSeveral human cytochrome P450 enzymes (P450s) found in steroid/oxysterol biosynthesis are therapeutic targets to treat disease. This review article describes current research strategies to develop various inhibitors of three steroid...The content of this RSS Feed (c) The Royal Society of ChemistryTu M. Ho
- Stereoselective design of amino acid bioconjugates: targeting strategies and physicochemical optimization December 24, 2025RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00760G, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Soma Mandal, Rajat Choudhary, V Badireenath KonkimallaA stereochemistry driven overview of amino acid bioconjugates, outlining targeting startegies and physicochemical design principles that advance anticancer, antimicrobial and CNS-directed therapeutics.To cite this article before […]Soma Mandal
- An overview of recent advancements in targeted cancer therapies and their potential clinical impact December 24, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00740B, Review ArticleShujauddin Ahmed, Akash P Sakla, Kousar Jahan, Naziya Neshat, Mymoona Akhter, Shams Aaghaz, Ahmed KamalRecent advances in medicine and drug development have significantly changed how cancer is treated. The success of inhibitors like sotorasib and adagrasib has expanded options for targeting once 'undruggable' oncogenic...The content of this […]Shujauddin Ahmed
- Kupffer cell M2-like polarization increases liver metastatic burden via uptake of exosomal KRAS mutant protein from hypoxic colorectal carcinoma cells December 20, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00897B, Research ArticleYu You, Zhihao Feng, Jiao Lu, Jie Xu, Ke You, Fuyao Liu, Tianzhu Wu, Hua Song, Zuojin LiuBackgrounds: This study is to investigate the metastasis promoting effect of colorectal carcinoma cells-derived exosomes in liver metastasis, M2-like polarization of Kupffer cells and the mechanism underlying. Methods: Mouse liver...The […]Yu You
- Screening apelin analogues and a small molecule agonist as effective cardiovascular therapeutics against reperfusion injury December 19, 2025RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00985E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anjalee Wijewardane, Kleinberg X. Fernandez, Anran Zhang, Conrad Fischer, Dineth P. Nagahawatta, Xavier Iturrioz, Charlotte Avet, Bethan L. Heard, Catherine Llorens-Cortes, Gavin Y. Oudit, Michel Bouvier, John C. VederasIn this study, we […]Anjalee Wijewardane
- Discovery of Enaminone-Linked Benzofuran Derivatives as Dual VEGFR-2/hCA IX Inhibitors Exhibiting Hypoxia-Mediated Chemosensitization December 18, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01043H, Research ArticleWagdy M. Eldehna, Zainab Elsayed, Mohamed Elnagar, Andrea Ammara, Mahmoud S Elkotamy, Rehan Monir, Alessio Nocentini, Mohammad M. Al-Sanea, Claudiu Supuran, Haytham O. Tawfik, Hatem A. Abdel-Aziz, Ahmed T. NegmeldinThe overexpression of VEGFR-2 and carbonic anhydrase IX (hCA IX), two proven therapeutic targets in aggressive malignancies, is […]Wagdy M. Eldehna
- Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking December 18, 2025RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00794A, Research ArticleYasmin Y. Omar, Ghada F. Elmasry, Dina S. El-kady, Ahmed A. Abd-Rabou, Samir M. El-Moghazy, Fadi M. Awadallah, Gamal A. Elmegeed, Ghada H. ElsayedThis study developed novel progesterone-based CDK8 inhibitors and demonstrated their anticancer activity against A549 cells in CS-PEG nanoform, supported by gene expression analysis, CDK8 […]Yasmin Y. Omar
- On the History, Synthesis, and Medicinal Use of Cantharidin, LB-100, and Their Analogs December 18, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00917K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kevin A. Scott, Jon T Njardarson, Adam McCluskey, Wei WangCantharidin, a defensive toxin produced by blister beetles, has fascinated chemists, physicians, and historians for centuries. From its notorious use as the aphrodisiac […]Kevin A. Scott
- N-Cyano Sulfoximine-Mediated Thiazole Ligation with N-Terminal Cysteine under Mild Aqueous Conditions December 16, 2025RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00948K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eunsil Kim, Ji Young Hyun, Ji Ho Song, Hwan Jung Lim, Seong Jun ParkAn N-terminal cysteine-selective click reaction employing N-cyano sulfoximines enables rapid thiazole formation under mild conditions. These three-demensional, hydrophilic scaffolds […]Eunsil Kim
- Revealing deamidation and isoaspartate formation during peptide analysis, purification and storage by tandem mass spectrometry December 29, 2025
