RSC – RSC Med. Chem. latest articles- Design, synthesis, and biological evaluation of substituted oxopyridine derivatives as selective FXIa inhibitors May 27, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD01013B, Research ArticleYanshi Wang, Sida Yan, jianglin Yuan, Xiaoyan Meng, Peng Liu, Shijun Zhang, Fancui Meng, Wei Liu, Shuhao Zhang, Changjiang Huang, Qunchao WeiTo explore selective FXIa inhibitors, a series of compounds were rationally designed with computer-aid drug design (CADD) and synthesized by introducing hydrophobic P1 fragments which could […]Yanshi Wang
- Identification of alkynyl nicotinamide HSN748 as a RET solvent-front mutant inhibitor with intracranial efficacy May 27, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00245A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ujjwol Khatri, Neetu Dayal, Kofi B. Owusu, Mandeep Kaur Hunjan, Shriya Pandey, Haley A. Harper, Carli McMahan, Bennett D. Elzey, Tao Shen, Xueqing Hu, Kurt W. Evans, Ahmed El-Sheikh, Jo Seong jun, […]Ujjwol Khatri
- Design, Synthesis, Molecular Modeling, and Antiproliferative Evaluation of New 2-Oxoindolin-3-ylidene Thiazole Derivatives May 27, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00332F, Research ArticleAalaa F. El-Mokadem, Mohammed K. Abd El-Gaber, Pak Hei Chung, Siang-Boon Koh, Hoda Y. Hassan, Adel Fawzy YoussefA series of novel 2-oxoindolin-3-ylidene thiazole derivatives were designed and synthesized, inspired by the pharmacophoric features of the VEGFR-2 inhibitor sunitinib. These compounds were evaluated for antiproliferative activity against a...The […]Aalaa F. El-Mokadem
- Navigating the complexities of drug development for Metallo-β-lactamase Inhibitors May 26, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00035A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nakita Reddy, Alessandra Moraes Balieiro, José Rogério A. Silva, Christiaan Arnoldus Gouws, Awelani Mutshembele, Per I. Arvidsson, Hendrik G. Kruger, Thavendran Govender, Tricia NaickerThe rising antibiotic resistance rates, especially among carbapenem-resistant Enterobacterales […]Nakita Reddy
- The relationship between cancer risk and cystic fibrosis: the role of CFTR in cell growth and cancer development May 26, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00203F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Radek Indra, Věra ČernáCystic fibrosis (CF) is a life-limiting genetic disease that affects multiple organ systems and has impact on cancer risk.To cite this article before page numbers are assigned, use the […]Radek Indra
- New ionizable lipids for non-viral mRNA delivery with secondary amine cyclic ether head groups May 26, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00115C, Research ArticleEric L. Dane, Aditya R. Pote, Martin Hemmerling, Werngard Czechtizky, Liping Zhou, Annette BakFrom a library of ionizable lipids based on a secondary amine, we identify high performers and report key structure–activity relationships driving lipid nanoparticle-based mRNA delivery.To cite this article before page numbers are assigned, use […]Eric L. Dane
- Five Years of Research on 2,4-Thiazolidinediones as Anticancer Agents: Medicinal Chemistry Insights (2020–2024) May 26, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00344J, Review ArticleNeeru Malik, Rajesh Kumar Singh2,4-Thiazolidinediones (2,4-TZDs) are a class of heterocyclic compounds traditionally recognized for their antidiabetic activity, particularly as peroxisome proliferator-activated receptor gamma (PPARγ) agonists. However, in recent years, they have emerged as...The content of this RSS Feed (c) The Royal Society of ChemistryNeeru Malik
- Synthetic Chemistry Enabling the Discovery and Development of a Series of Pyrazoles as HPK1 Inhibitors May 26, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00309A, Research ArticleAnthony J. Metrano, Lucas Morrill, Gayathri Bommakanti, Robert Casella, Steve Cook, Randolph A Escobar, Kathryn Giblin, Eric Gosselin, Tyler Grebe, Niresh Hariparsad, Rachel Howells, Gillian Lamont, Deanna A. Mele, Alexander Pflug, Theresa Proia, Hadi Rezaei, Magdalena Richter, Ryan Richards, Maryann San Martin, Marianne Schimpl, Alwin G. Schuller, […]Anthony J. Metrano
- Novel benzimidazole hybrids: design, synthesis, mechanistic studies, antifungal potential and molecular dynamics May 26, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00122F, Research ArticleAhmed A. Ibrahim, Eman G. Said, Asmaa M. AboulMagd, Noha H. Amin, Hamdy M. Abdel-RahmanThe two designed compounds 11 and 12 showed significat antifungal activity supported by molecular studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Ahmed A. Ibrahim
- Lysine targeting covalent inhibitors of malarial kinase PfCLK3 May 26, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00335K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Skye Brettell, Gillian Cann, Abbey Begen, Saumya Sharma, Amit Mahindra, Lauren Carruthers, Graeme Milligan, David Clarke, Andrew B Tobin, Andrew George JamiesonMalaria continues to devastate tropical regions of the world, with resistance […]Skye Brettell
- Design, synthesis, and biological evaluation of substituted oxopyridine derivatives as selective FXIa inhibitors May 27, 2025
