RSC – RSC Med. Chem. latest articles- Synthesis and evaluation of 14β-acyl substituted 17cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors February 12, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00685F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mehrnoosh Ostovar, Keith Olsen, Gerta Cami-Kobeci, John Traynor, Luka Jeramaz, Stewart B Kirton, Stephen M. HusbandsOpioids remain the standard of care for management of severe pain, but adverse effects limit their use, […]Mehrnoosh Ostovar
- Biocompatible de novo indolylchalcones as platelet aggregation inhibition and diabetic wound healing agents February 11, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00984G, Research ArticleSumit Kumar, Radhika Chaurasia, Gaurav Kumar, Arun K. Sharma, Ijaz Ahmed, Alam Nur-E-Kamal, Monalisa Mukherjee, Brajendra K. Singh, Virinder S. ParmarBiocompatible de novo indolylchalcones exhibit anti-platelet aggregation and nitric oxide-mediated effects. They show antiplatelet activity and accelerated diabetic wound healing, indicating promise for diabetic wounds and cardiovascular […]Sumit Kumar
- Emerging Strategies for Alzheimer's Disease: Leveraging Flavonoid Derivatives for Early Diagnosis and Neuroprotection February 11, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01026H, Review ArticleZhe Han, Wenling Fu , Mingjuan Dai , Roujun Lu, Jianhua Yu, Wu Dong, Zhi-Pei SangAlzheimer's disease (AD) is a prevalent chronic and progressive neurodegenerative disorder predominantly affecting the elderly population. The etiology of AD is multifaceted, and despite extensive research, effective therapeutic options remain...The content of […]Zhe Han
- Verbenone-Based Selenophene Derivatives as Potential Anti-cancer Agents: Synthesis and Biological Evaluation in 2D and 3D A549 Cell Models February 11, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01140J, Research ArticleJiale Han, Wei Shi, Min Hu, Hongmei Wu, Wei Liu, Biao Xiong, Xiaodong Qiu, Yunyun WangNatural-product-inspired scaffolds remain a valuable source of novel anticancer agents. In this study, a series of verbenone-selenophene hybrids (2A-2U) were rationally designed. Their antiproliferative activities were evaluated in vitro against...The content of […]Jiale Han
- Harnessing Oligonucleotide Architecture for Potent Multivalent Inhibition of Human Carbonic Anhydrases February 6, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01167A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eslam Morad Abbass, FEDERICO LADU, Justine Mansot, Mathieu Noël, Alessio Nocentini, Mario Sechi, Claudiu Supuran, Michael Smietana, Jean-Yves WinumThis study presents the design and synthesis of a novel class of carbonic anhydrase […]Eslam Morad Abbass
- Synthesis and biological evaluation of carabrol derivatives February 6, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00940E, Research ArticleHaidi Wu, Mengshi Zhao, Shifeng Ren, Xiaodong Mu, Yanqin Lu, Yuji Liang, Jingyong SunA carabrol derivative reduces the production of the inflammatory mediator NO in macrophages by inhibiting the expression of iNOS and COX-2.To cite this article before page numbers are assigned, use the DOI form of […]Haidi Wu
- Introducing CLipPA Lipid Chemodiversity to Enzymatically Truncated Polymyxin B: A Soft Drug Strategy to Combat Gram-Negative Pathogens February 6, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01141H, Research ArticleTae-Ung Na, Yann Hermant, Andrew Siow, Jeremy George Owen, Susanna Chan, Gavin Frank Painter, Cameron C Hanna, Zillah Daysh, Beatrix L Goggin, Jane R. Allison, Veronika Sander, Alan J Davidson, Georgia Campbell, Scott A. Ferguson, Gregory M Cook, Paul Harris, Margaret A Brimble, Alan James CameronA chemodiverse […]Tae-Ung Na
- 3-(Pyridine-3-ylmethylene)chroman-4-one and tetralone derivatives: synthesis, Mycobacterium tuberculosis CYP121A1 enzyme inhibition and antimycobacterial activity vs drug-sensitive and drug-resistant strains February 4, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00738K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Claire Simons, Lama A Alshabani, Jabril M Abdali, Alistair Brown, Damião Pergentino De Sousa, Sam Willcocks, Amit Kumar, Ahmed Y.G. Alhejaili, D. Fernando EstradaCYP121A1 is a promising cytochrome P450 (CYP) drug target […]Claire Simons
- Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti-Mycobacterium tuberculosis agents February 4, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00997A, Research ArticleAhmed Sabt, Małgorzata Korycka-Machała, Asmaa F. Kassem, Abdulrahman M. Saleh, Hanaa Farag, Moataz A. Shaldam, Mohamed G. Thabit, Anna Brzostek, Magdalena Kuzioła, Bożena Dziadek, Hoda Atef Abdelsattar Ibrahim, Xinsheng Lei, Jarosław Dziadek, Mohamed A. AbdelrahmanThe updated guidelines from the World Health Organization highlight that treatment options for […]Ahmed Sabt
- Medicinal Attributes of Nitrogen Heterocycles Directing Aldose Reductase Selectivity and Potency February 4, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01038A, Review ArticleAnita Kumari, Shyamal Kumar Manna, Kajal Rani, Rupali Kohal, Ghanshyam Das Gupta, Sant Kumar VermaDiabetic complications arise primarily from hyperglycemia-induced metabolic disturbances, among which the polyol pathways play a significant role through the overactivation of aldose reductase. ARLs have therefore emerged as a potent...The content of this […]Anita Kumari
- Synthesis and evaluation of 14β-acyl substituted 17cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors February 12, 2026
