RSC – RSC Med. Chem. latest articles- Bridging traditional and contemporary approaches in computational medicinal chemistry: opportunities for innovation in drug discovery October 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00700C, Review ArticleAldo Sena de OliveiraThe field of Computational Medicinal Chemistry has undergone significant advancements, transitioning from traditional methodologies to contemporary strategies powered by artificial intelligence, machine learning, and big data. Traditional approaches, such as...The content of this RSS Feed (c) The Royal Society of ChemistryAldo Sena de Oliveira
- Novel magnolol-sulforaphane hybrids as potent antitumor agents: Synthesis and biological characterization October 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00733J, Research ArticleYuwei Peng, Bing Liu, Yishan Guo, Junhong Chen, Haoxiong Chen, Xueyi Liu, Junchang Huang, Daqiang Luo, Yimin Hong, Dudu Wu, Zhi Chen, Xian Lin, Tao ChengThe natural product-based hybrid strategy is a promising approach for innovative drug discovery. Leveraging the privileged architecture of sulforaphane—a prominent anticancer natural […]Yuwei Peng
- Identification of p-Aminobenzylamine Derivatives as Dual Non-Covalent Inhibitors of the Transmembrane Host Proteases TMPRSS2 and HAT Proteases with Anti-viral Potential October 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00680E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hélène Carvaillo, Ashok Dussol, Nancy Chaaya, Sara Kadri, Feryel Soualmia, Nicolas MASURIER, Chahrazade El AmriTMPRSS2 and HAT (or TMPRSS11D) are host serine proteases critically involved in the entry of several respiratory viruses, […]Hélène Carvaillo
- Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein October 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00625B, Research ArticleLaura Depta, Nianzhe He, Maria Lillevang Madsen, Matilde Lind Hartvig Nielsen, Hogan P. Bryce-Rogers, Samantha C. Waterworth, Jeffrey D. Neighbors, David P. Stockdale, Michael P. Callahan, Nolan R. Mente, John Beutler, David Wiemer, Luca LaraiaSchweinfurthins (SWs) are natural products isolated from the plant genus Macaranga which display […]Laura Depta
- C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease October 27, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00789E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dorian-Gabriel Muntean, Wojtek Treyde, Linda Kinena, Eidarus Saleh, Hani Choudhry, Fernanda Duarte, Lennart Brewitz, Christopher J SchofieldInhibition of the SARS-CoV-2 main protease (Mpro) by small-molecules is a validated strategy for COVID-19 treatment. […]Dorian-Gabriel Muntean
- Isatin, a monoamine oxidase inhibitor, sensitizes resistant breast cancer cells to tamoxifen via MAO-A/HIF1α/MMPs modulation October 27, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00694E, Research ArticleFatma M. Abdelwahed, Marwa A. Ibrahim, Marwa Sharaky, Heba EffatIsatin enhances the anticancer activity of tamoxifen in resistant breast cancer cells by inhibiting MAO-A, inducing apoptosis and overcoming drug resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Fatma M. Abdelwahed
- Glioblastoma Antitumoral Activity of Tetrahydroquinoline-derived Triarylmethanes October 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00585J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniela Branco, Zahra Yektaei, Sureka Chandrabose, Filipe Alexandre Almeida Paz, Meenakshisundaram Kandhavelu, Nuno R. CandeiasGlioblastoma multiforme (GBM) is an aggressive and treatment-resistant brain tumor. The expansion of a phenolic Mannich base library […]Daniela Branco
- Design, Synthesis, and Biological Evaluation of Sulfonamide-Functionalized Pyridine Carbothioamides as Potent Tubulin-Targeting Anticancer Agents October 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00693G, Research ArticleFatima Younas, Jahan Zaib Arshad, Waqas Ali Shah, Sundas Arshad, Adnan Ashraf, Syed Shoaib Ahmad Shah, Muhammad Asam Raza, Amara Mumtaz, Nasir Shahzad, Tariq JavedAbstract Pyridine carbothioamides (PCAs) are recognized for their gastric mucosal protective effects and low in vivo toxicity, making them attractive scaffolds for anticancer […]Fatima Younas
- From fragments to follow-ups: rapid hit expansion by making use of EU-OPENSCREEN resources October 21, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00684H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Laila S. Benz, Jan Wollenhaupt, Aigars Jirgensons, Tanja Miletic, Uwe Mueller, Manfred S. WeissDefinition and validation of EFSL-96, a 96-membered subset of the European Fragment Screening Library. Hits and follow-up binder identification […]Laila S. Benz
- Investigating NFE2L1 Activators for Targeted Protein Aggregate Clearance: A Follow-Up Study October 21, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00584A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zuzana Šmahelová, Lucie Svobodová, Jindřich Sedláček, Michael Adámek, Marketa Pimkova Polidarova, Pavel Majer, Ales Machara, Klara SaskovaDisruption of protein homeostasis (proteostasis), whether by acute proteotoxic stress or chronic expression of mutant proteins, […]Zuzana Šmahelová
- Bridging traditional and contemporary approaches in computational medicinal chemistry: opportunities for innovation in drug discovery October 29, 2025
