RSC – RSC Med. Chem. latest articles- X-ray crystallographic and kinetic studies of biguanide containing aryl sulfonamides as Carbonic anhydrase inhibitors January 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD01018C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chiara Baroni, Murat Bozdag, Gioele Renzi, Viviana De Luca, Clemente Capasso, Carla Bazzicalupi, S. Selleri, Marta Ferraroni, Fabrizio Carta, Claudiu SupuranHere we report a small series of dual-targeting compounds that combine the […]Chiara Baroni
- Aspirin Vs Ibuprofen: Unveiling Distinct Cyclooxygenase-1/2 Behaviour and Dual Efficacy of Their Synthesized Analogues via Molecular Modeling and In-Vitro Biological Assessment January 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00751D, Research ArticleAmandeep Kaur, Manisha Bansal, Hafiz Rehman, Vipin Kumar Mishra, Gurmeet Kaur, Mandeep Kaur, Mohammad K. Okla, Masaud ShahDual inhibition of cyclooxygenase isozymes along with platelet aggregation activities via the arachidonic acid pathway may provide a better anti-inflammatory agent with enhanced cardiac safety. Although the literature is more...The […]Amandeep Kaur
- Discovery of potent measles virus fusion inhibitor peptides via structure-guided derivatization January 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD01006J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ziwei Gao, Jiei Sasaki, Tateki Suzuki, Tomoaki Suzuki, Yuki Miwa, Shinsuke Sando, Takao Hashiguchi, Jumpei MorimotoFusion inhibitor peptide (FIP), a short peptide known as a measles virus (MeV) infection inhibitor, inhibits membrane […]Ziwei Gao
- Isozyme specific inhibition of GSTP1-1; A crucial element in cancer targeting drugs January 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00872C, Review ArticleBelal O. Al-Najjar, Muath Helal, Fadi G. Saqallah, B. BandySelectively targeting cancer cells has been a main challenge in cancer therapy. The purpose is to spare normal cells and minimize side effects. Targeting the antioxidant enzymes (i.e. GST) for...The content of this RSS Feed (c) The Royal […]Belal O. Al-Najjar
- Relocating NSAID into endoplasmic reticulum induces ER stress -mediated apoptosis in cancer cells January 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00936C, Research ArticleTripti Mishra, Preeti ., Jaypalsing Ingle, Aditi Saha, Sudipta BasuThe endoplasmic reticulum (ER) is a vital subcellular organelle that orchestrates numerous essential biological processes, including protein synthesis and processing. Disruption of ER function can lead to ER stress, a...The content of this RSS Feed (c) The Royal […]Tripti Mishra
- The Physics-AI Dialogue in Drug Design January 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00869C, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pablo Andrés Vargas-Rosales, Amedeo CaflischA long path has led from the determination of the first protein structure in 1960 to the recent breakthroughs in protein science. Protein structure prediction and design methodologies […]Pablo Andrés Vargas-Rosales
- Expanding the Chemical Space for Antiviral Discovery: The Potential of Twistenediones January 22, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00891J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aida Jaafar, Daniel Guerra-González, Ana Pascual, Ana Ortuño, Carlos M. Cruz, Juan Manuel Cuerva, Paula Bueno, Victoria Castro, Urtzi Garaigorta, Pablo Gastaminza, Javier Adrio, Maria RibagordaDespite significant progress in drug discovery, there […]Aida Jaafar
- Probing structural requirements for thiazole-based mimetics of sunitinib as potent VEGFR-2 inhibitors January 22, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00754A, Research ArticleAlaa A. Abd Elhameed, Ahmed R. Ali, Hazem A. Ghabbour, Said M. Bayomi, Nadia S. El-GoharyNovel thiazole analogs 3a, 3b, 4, 5, 6a–g, 8a, 8b, 9a–c, 10a–d and 11 were designed and synthesized as molecular mimetics of sunitinib.To cite this article before page numbers are assigned, use […]Alaa A. Abd Elhameed
- A perspective on small molecules targeting the Renin-Angiotensin-Aldosterone System and their utility in cardiovascular diseases: Exploring the structural insights for rational drug discovery and development January 21, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00720D, Review ArticleNisha Bansal, Deepika Kathuria, M. Arockia Babu, Sonia Dhiman, Sorabh Lakhanpal, Roshan Kumar, Yogita Tyagi, Bhupinder Kumar, Mahendra Pratap Singh, Abhay M Gaidhane, K Nagendra PrasadThe Renin-Angiotensin-Aldosterone System (RAAS) is crucial in cardiovascular homeostasis. However, the disruption in this homeostasis often leads to numerous cardiovascular diseases (CVDs) […]Nisha Bansal
- Design, Synthesis, Antimicrobial Activity, Stability, and Mechanism of Action of Bioresorbable Ceragenins January 21, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00990H, Research ArticleShawn Gubler, Aaron Zaugg, Rebekah Yi, Elliot Sherren, Elizabeth Rae Milner, Wesley Conyer, Tate May, Tim Jack, Tanner Heaton, Joel Christopherson, Preston Higbee, Emma Powers, Meg Takara, Anna Linder, Boston Boyack, Fetutasi Pauga, Shenglou Deng, Morgann Salmon, Miriam Thomas, Mariko Shiraki, Paul B. SavageDevice-related infections (DRIs) from […]Shawn Gubler
- X-ray crystallographic and kinetic studies of biguanide containing aryl sulfonamides as Carbonic anhydrase inhibitors January 24, 2025
