RSC – RSC Med. Chem. latest articles- Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation August 5, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00438A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Esther Oreoluwa Olaniran Håkansson, Lorenzo Balestri, Sharathna Puthiyaparambath, Sebastian Moes, Henning Henschel, Christian Sköld, Mathias Hallberg, Mats Larhed, Bobo Skillinghaug, Luke R OdellInhibition of the Insulin-Regulated Aminopeptidase (IRAP) is a promising therapeutic […]Esther Oreoluwa Olaniran Håkansson
- Synthetic and structure–activity studies of SP2577 and TCP towards LSD1 targeting PROTACs August 4, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00420A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Megan E. Coulson, James K. S. Norris, Sean A. Smith, Joshua P. Smalley, John W. R. Schwabe, Shaun M. Cowley, James T. HodgkinsonAn SAR study of SP2509/SP2577 and TCP-based PROTACs targeting LSD1 […]Megan E. Coulson
- Novel small molecule derivatives improve survivability in cellular model of Huntington’s disease via improving mitochondrial fusion July 31, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00345H, Research ArticleKodam Pradeep, Vaishali Kumar, Paramita Pattanayak, Praharsh Vitta, Tanmay Chatterjee, Shuvadeep MaityMitochondrial dysfunction is one of the primary cellular conditions involved in developing Huntington's Disease (HD) pathophysiology. The accumulation of mutant huntingtins protein with abnormal PolyQ repeats resulted in the death...The content of this RSS Feed (c) […]Kodam Pradeep
- Hinge Binder Modification into Imidazopyridine for Targeting Actionable Mutations of RET Kinase July 31, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00397K, Research ArticleArunkranthi Maturi, Vinay Pogaku, Surendra Kumar, Mi-Hyun KimThe RET proto-oncogene plays a critical oncogenic driver in the development of several cancers. Despite the existence of clinically approved RET inhibitors, their limited response rates and the emergence of...The content of this RSS Feed (c) The Royal Society of […]Arunkranthi Maturi
- A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2 July 31, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00440C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Laura Hillebrand, Guiqun Wang, Alexander Rasch, Benedikt Masberg, Apirat Chaikuad, Thales Kronenberger, Ellen Günther, Michael Forster, Antti Poso, Michael Lämmerhofer, Stefan A. Laufer, Stefan Knapp, Matthias GehringerA fluorosulfate inhibitor designed for tyrosine […]Laura Hillebrand
- Exploring novel thiazole-based minor groove binding agents as potential therapeutic agents against pathogenic Acanthamoeba castellanii July 30, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00475F, Research ArticleHasan Alniss, Ruqaiyyah Siddiqui, Meshal Daalah, Hadeel AlJubeh, Yousef Msallam, Bader Alawfi, Sreedevi Sajeev, Anil Ravi, Naveed Ahmed KhanDue to limited advances in diagnosis and targeted therapy, as well as poor understanding of pathophysiology, infections due to Acanthamoeba have remained a medical concern. With their ability to […]Hasan Alniss
- Discovery of a potent and selective PROTAC degrader for STAT3 July 30, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00260E, Research ArticleKefeng Wang, Yuxin Zheng, Wenli Mao, Jing Xu, Yukun WangA potent and selective STAT3 degrader S3D5 was developed, inducing potent STAT3 degradation in vitro.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Kefeng Wang
- Cyclometalated Complexes: Promising Metallodrugs in the Battle Against Cancer. July 30, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00178A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrés Amaya-Flórez, Jordi R.-Galindo, Elkin Sanchez-Yocue, Adrian Ruiz-Martinez, Juan Sebastián Serrano-García, Adriana Romo-Pérez, Patricia Cano-Sánchez, Viviana Reyes-Marquez, Ronan Le Lagadec, David Morales-MoralesMetal-based treatments are an excellent alternative as drugs for oncological treatment […]Andrés Amaya-Flórez
- Toward routine utilisation of native mass spectrometry as an enabler of contemporary drug development July 29, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00617A, OpinionLouise M. Sternicki, Sally-Ann PoulsenWe discuss how native mass spectrometry (nMS) is contributing important analytical insights to guide contemporary drug discovery and development. We focus on diverse modalities including targeted protein degradation (TPD), fragments (FBDD) and mRNA.To cite this article before page numbers are assigned, use the DOI […]Louise M. Sternicki
- Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling July 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00350D, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cameron Taylor, Grace Roper, Rhianna Young, Fredrik Svensson, Andreas Brunschweiger, Sam Butterworth, Andrew Leach, Michael James WaringDNA-encoded libraries (DELs) are established as an effective screening strategy to identify protein ligands and offer […]Cameron Taylor
- Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation August 5, 2025
