RSC – RSC Med. Chem. latest articles- Parallels between the chloro and methoxy groups for potency optimization January 19, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00848D, Research ArticleDebora Chiodi, Yoshihiro IshiharaThere are parallels between Cl and OCH3 in the types of ligand–protein interactions they engage in. The dual electrostatic versatility of these two substituents renders them useful scouts to probe protein pockets for potency optimization.To cite this article before page numbers are assigned, use […]Debora Chiodi
- Endoperoxide delivered singlet oxygen: The future of PDT, without light or oxygen January 17, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00887E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wanwan Wang, Lei Wang, rensong sun, Xiao Qian, ziang liu, Engin AkkayaChemically generated singlet oxygen via cycloreversion reaction of aromatic endoperoxides, is poised to evolve into a highly promising therapeutic protocol. Singlet […]Wanwan Wang
- Discovery of RP-37 Analogues as Potent, Selective Irreversible Inhibitors Targeting DNA Polymerase Theta (POLθ) January 16, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00830A, Research ArticleZhenwei Wang, Mengyuan Qiu, Deming Liu, Dongyan Gu, yanzhen yu, Fengmin Zhang, Rong ShengDNA polymerase theta (POLθ) is a promising synthetic lethal target for BRCA-deficient cancers, while reversible POLθ-pol inhibitors exhibit limited cellular efficacy. Here, we report the structure-guided discovery of RP-37 analogue...The content of this RSS […]Zhenwei Wang
- Novel Pt@BSA nanoparticles improve radiotherapeutic outcomes in breast cancer January 16, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00792E, Research ArticleYuhui Zhang, Yihui Liu, Dongju ZhengWe designed a novel nanoplatform, Pt@BSA-RM, that is capable of sensitizing breast cancer cells to radiotherapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYuhui Zhang
- 2,5-Diazabicyclo[2.2.1]heptane in Medicinal Chemistry: A Treasure Trove of Therapeutic Opportunities January 16, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00992H, Review ArticlePranav Kumar Ambast, Saumya Kapoor, Rudradip Das, Deep Rohan Chatterjee, Amit Shard2,5-Diazabicyclo[2.2.1]heptane (2,5-DBH) has emerged as a valuable scaffold in medicinal chemistry owing to its conformational rigidity and favorable three-dimensional architecture. In recent years, 2,5-DBH has been increasingly incorporated into biologically...The content of this RSS Feed (c) […]Pranav Kumar Ambast
- Exploiting intracellular oncogenic proteins to release cytotoxins January 15, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00764J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthias Schild, Dennis GillinghamThe success of antibody-drug conjugates illustrates the value of targeted delivery strategies for cytotoxic molecules. We present a novel approach to targeted delivery that uses intracellular covalent chemistry to […]Matthias Schild
- Exploring Pyrazoline-Thiophene Hybrids as CDK2 Inhibitors: Synthesis, Mechanistic, Biological Studies, and Computational Insights January 15, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD00910C, Research ArticleHeba M Abosalim, Tarek Elmoselhy, Nabaweya Sharafeldin, Mohamed S. Nafie, Mohamed K. Diab, Mervat H. El-Hamamsy, Haytham O. TawfikPyrazoline-linked thiophene (4a-p), a novel family of compounds, was designed and synthesized, and its anticancer potential was assessed. The most effective analogues of bis-thiophene (4n and 4o) and tris-thiophene […]Heba M Abosalim
- Investigating the role of cytochrome bd oxidases in the antibacterial activity of madecassic acid and derivatives thereof January 13, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01116G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samantha Henry, Geraud N Sansom, Thao Thi Phuong Tran, Ryan Boughton, Guy Joiner, Calum Webster, Hondamuni Ireshika Chathurani De Silva, Michelle D. Garrett, Gary Robinson, Christopher J. Serpell, Mark ShepherdNatural products are […]Samantha Henry
- Integrated computational screen and validation of thalidomide-based PROTACs targeting SARS-CoV-2 main protease January 13, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01003A, Research ArticleLi-Na Guo, Yu-Hua Li, Rou-Yu Zhu, Ni Su, Zhi-Yu Shao, Hua DiaoThree novel thalidomide-based PROTACs (A, B, and C) demonstrate efficient binding to and degradation of SARS-CoV-2 Mpro in transfected HEK293 cells with high selectivity, mediated through the ubiquitin–proteasome system.To cite this article before page numbers are […]Li-Na Guo
- Theranostic advances in Alzheimer's disease: structure-guided design of near-infrared fluorescent probes targeting amyloid-β and cholinergic dysfunction January 12, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD00713E, Review ArticleUpesh Mandloi, Namita Giri, Saroj Kumar, Gyan ModiRecent breakthroughs in rational design of alkene-bridged D–π–A NIR fluorescent probes that target AD hallmarks such as amyloid-β (Aβ) aggregation and cholinergic dysfunction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Upesh Mandloi
- Parallels between the chloro and methoxy groups for potency optimization January 19, 2026
