RSC – RSC Med. Chem. latest articles- Prodrugs and their activation mechanisms for brain drug delivery January 17, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00788C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ida Aaberg Lillethorup, Andreas Victor Hemmingsen, Katrine QvortrupProdrugs are masked drugs that first become pharmacologically active after undergoing a structural change in vivo.To cite this article before page numbers are assigned, use […]Ida Aaberg Lillethorup
- Synthesis and Screening of Novel 2,4-Bis Substituted quinazolines as Tubulin Polymerization Promotors and Antiproliferative Agents January 15, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00755G, Research ArticleAshish Ranjan Dwivedi, Vinod Kumar, Vijay Kumar, Vikash Prashar, Kailash Jangid, Naveen Kumar, Bharti Devi, Jyoti ParkashTwelve 2,4-Bis substituted quinazoline based compounds were synthesized and screened for antiproliferative and tubulin polymerization enhancing potential. In the series, compound A4V-3 substituted with an imidazole ring displayed IC50 values...The content […]Ashish Ranjan Dwivedi
- Heterocyclic Core Modifications in Trypanosomacidal 2-[(Phenylheteroaryl)ethyl]ureas January 15, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00764F, Research ArticleArthur Toynton, Lori Ferrins, Harriet Newson, Melissa Sykes, Swapna Varghese, Nghi Nguyen, Stephanie Russell, Raphaël Rahmani, Jeremy Cheang, Gavin Flematti, Brian W. Skelton, Bilal Zulfiqar, Vicky Mary Avery, Jonathan Bayldon Baell, Matthew PiggottThe protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, which cause Human African trypanosomiasis (HAT) and […]Arthur Toynton
- Development of small-molecule fluorescent probes targeting neutrophils via N-formyl peptide receptors January 14, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00849A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Qi Xu, Kalwant S. Authi, Liliya N. Kirpotina, Igor A. Schepetkin, Mark T. Quinn, Agostino CilibrizziN-formyl peptide receptors (FPRs) are membrane receptors that are abundantly expressed in innate immune cells, including neutrophils […]Qi Xu
- Development of benzofuran derived sulfamates as dual aromatase-steroid sulfatase inhibitors (DASIs): Design, synthesis and biological evaluation January 9, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00795F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ahmed G. Eissa, Claire Simons, Francesca Gozzi, Oqab Aloqab, Charlotte E. Parrish, Nadira Mohamed, Irene Shiali, Harith Al-Baldawi, Paul A. FosterResistance to current therapies for the treatment of oestrogen receptor positive (ER+) […]Ahmed G. Eissa
- Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5-a]pyridine-based chalcones January 8, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00838C, Research ArticleRamu Gopathi, Mommuleti Pradeep Kumar, Gangasani Jagadeesh Kumar, Syamprasad N. P., Bheeshma Geetanjali Kodiripaka, V. G. M. Naidu, Bathini Nagendra BabuDesign, synthesis, characterization of a series of imidazo[1,5-a]pyridine-chalcones and evaluated their cytotoxicity. Apoptotic induction, ROS-mediated mitochondrial damage, immuno-fluorescence, microtubule disruption and docking were also studied.To cite this […]Ramu Gopathi
- Saponin components exhibit antiviral properties against porcine epidemic diarrhea virus in vitro January 8, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00894D, Research ArticleYiyi Hu, Yunchuan Li, Haodan Zhu, Dandan Wang, Junming Zhou, Bin LiFour saponins could efficiently modulate the immune response against PEDV and hold promise for utilization in antiviral treatments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Yiyi Hu
- Breaking the energy chain: importance of ATP synthase in Mycobacterium tuberculosis and its potential as a drug target January 8, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00829D, Review ArticleSummaya Perveen, Sunny Pal, Rashmi SharmaInhibitors of mycobacterial ATP synthase, such as bedaquiline, TBAJ-587, TBAJ-876, squaramides, GaMF1, and DeMF1, break the energy metabolism and effectively inhibit Mtb, offering promising strategies against mycobacterial infections.To cite this article before page numbers are assigned, use the DOI form of citation […]Summaya Perveen
- A novel multipotent conjugate bearing tacrine and donepezil motifs with dual cholinergic inhibition and neuroprotective properties targeting Alzheimer’s disease January 7, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00804A, Research ArticleAndrés F. Yepes, Wilson Cardona, Angie Herrera-Ramirez, Marlyn Rada, Edison Osorio, Luis Alfonso Gonzalez, Yaneth Miranda, Rafael Posada-DuqueIn this work, we had developed potential multifunctional agents to combat Alzheimer´s disease. Our strategy merge fragments of tacrine and donepezil in a unique hybrid structure. These compounds were synthetized...The […]Andrés F. Yepes
- Lazertinib: Breaking the mold of third-generation EGFR inhibitors January 7, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00800F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kishan B. Patel, David E. HeppnerSmall molecules targeting activating mutations within the epidermal growth factor receptor (EGFR) are efficacious anticancer agents, particularly in non-small cell lung cancer (NSCLC). Among these, lazertinib, a […]Kishan B. Patel
- Prodrugs and their activation mechanisms for brain drug delivery January 17, 2025
