RSC – RSC Med. Chem. latest articles- Synthesis, Characterization, and Toxicity Evaluation of Ciprofloxacin-Chloranilic Acid Charge Transfer Complexes: Potential for Anticancer Applications March 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00091B, Research ArticleMahmoud M. Ali, Muhammad Alaa Eldeen, Mohamed E. El Awady, Ahmed A. Hamed, Heba A. H. Abd Elhameed, Amira Awadallah, Mohamed Alshehri, Hassan M. Otifi, Dalal Sulaiman Alshaya, Eman Fayad, Dalal Nasser Binjawhar, Mohamed AliBackground: Ciprofloxacin (CIP), an FDA-approved antimicrobial agent, is commonly used to treat a […]Mahmoud M. Ali
- VHL-independent degradation of Hepatitis B Virus e antigen (HBeAg) by VHL-binding chimeric small molecules. March 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00118H, Research ArticleLiam Hales, Simon Mountford, Mina Takawy, Danni Colledge, Belinda Maher, Jake Shortt, Philip Evan Thompson, Sam Greenall, Nadia WarnerHepatitis B virus (HBV) is a leading cause of liver cancer worldwide, with current treatment options unable to provide lasting efficacy against chronic infection. A key viral protein, HBV […]Liam Hales
- Novel N-(4,5,6,7-tetrahydrobenzisoxazol-4-yl)amides as Hsp90 inhibitors: design, synthesis and biological evaluation March 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00904E, Research ArticleNastassia A. Varabyeva, Alexander M. Scherbakov, Diana I. Salnikova, Danila Sorokin, Alvina Khamidullina, Alexandra L. Mikhaylova, Dzmitry I. Paulovich, Fedor A. Lakhvich, Yuri A. PivenNovel N-(4,5,6,7-tetrahydrobenzisoxazol-4-yl)amide derivatives were designed and synthesized as potential HSP90 inhibitors. The synthetic pathway commenced with 6,7-dihydrobenzo[d]isoxazol-4(5H)-ones, utilizing the Ritter reaction as a […]Nastassia A. Varabyeva
- Unravelling the potency of the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile scaffold with S-arylamide hybrids as PIM-1 kinase inhibitors: synthesis, biological activity and in silico studies March 28, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00021A, Research ArticleSoha R. Abd El Hadi, Manar A. Eldinary, Amna Ghith, Hesham Haffez, Aya Salman, Ghadir A. SayedDiscovery of new PIM-1 inhibitors with the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile scaffold with S-arylamide hybrids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Soha R. Abd El Hadi
- Antiproliferative effects, Mechanism of Action and Tumor Reduction Studies in a Lung Cancer Xenograft Mouse Model of an Organometallic Gold(I) Alkynyl Complex March 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00964A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Uttara Basu, Anna Wilsmann, Sebastian Türck, Henrik Hoffmeister, Matthias Schiedel, Gilles Gasser, Ingo OttOrganometallic complexes offer a wide range of properties like structural variety, reaction kinetics, tunable lipophilicity and alternate mechanisms of […]Uttara Basu
- Thiochromenes and thiochromanes: a comprehensive review of their diverse biological activities and structure–activity relationship (SAR) insights March 24, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00995A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Jatin, Solai Murugappan, Shivani Kirad, Chandu Ala, Pranali Vijaykumar Kuthe, Chandra Sekhar Venkata Gowri Kondapalli, Murugesan SankaranarayananMedicinal potential of thiochromene and thiochromane scaffolds, highlighting their importance in various diseases.To cite this […]Jatin
- Contributors to our Emerging Investigators collection March 24, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD90009C, ProfileRSC Medicinal Chemistry profiles the contributors to the ‘Emerging Investigators’ themed collection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
- The Allosteric Inhibitor Targeting STAT3 Coiled-Coil Domain,Selectively Suppresses Proliferation of Breast Cancer March 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00926F, Research ArticleMin Huang, Wei Wang, Liyue Cao, Jiaxin Liu, Can Du, Jian ZhangSignal transducer and activator of transcription 3 (STAT3) remains a challenging and attractive therapeutic target in cancer research. The coiled-coil domain (CCD) of STAT3 represent a novel site for targeted...The content of this RSS Feed (c) […]Min Huang
- Near-Infrared Photochemical Internalization: Design of a Distorted Zinc Phthalocyanine for Efficient Intracellular Delivery of Immunotoxins March 21, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00931B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mikako Hamabe, Wakako Dewa, Mizue Yuki, Eriko Yamada, Tamako Aiba, Keisuke Horikoshi, Takao Hamakubo, Riuko Ohashi, Akimitsu OkamotoIn the treatment of cancer, the physical and mental stress on patients and the potential […]Mikako Hamabe
- Methods for kinetic evaluation of reversible covalent inhibitors from time-dependent IC50 data March 20, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00050E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lavleen K. Mader, Jeffrey W. KeillorA newly derived implicit equation and a new modelling method, EPIC-CoRe, allow for complete kinetic evaluation of reversible covalent inhibitors from time-dependent IC50 data.To cite this article […]Lavleen K. Mader
- Synthesis, Characterization, and Toxicity Evaluation of Ciprofloxacin-Chloranilic Acid Charge Transfer Complexes: Potential for Anticancer Applications March 29, 2025
