RSC – RSC Med. Chem. latest articles- The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition. November 22, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00913H, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Juliet Strang, Daniel Astridge, Caleb Chandler, Vu Nguyen, Philip ReiganAMP-activated protein kinase (AMPK) acts as a central cellular sensor at the interface of metabolic and signaling networks, that supports cell survival in […]Juliet Strang
- An exploration of potent antileishmanial agents derived from quinoline–thiazole and thiadiazole hybrids, targeting DHFR-TS and PTR1: design, synthesis, and computational analyses November 19, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00709G, Research ArticleHuda R. M. Rashdan, Adnan A. Bekhit, Veronika Furlan, Kikuko Amagase, Abdelsamed I. Elshamy, Nourhan Elfar, Mohamed. R. Abdo, Tamer M. Ibrahim, Urban Bren, Wagdy M. Eldehna, Ahmed SabtNeglected tropical diseases (NTDs) encompass a broad spectrum of infectious diseases predominantly found in tropical and subtropical regions.To cite […]Huda R. M. Rashdan
- Potent and Selective Indole-based Inhibitors Targeting Disease-Transmitting Mosquitoes November 19, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00797F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rajeshwari Choudhary, Valentin Duvauchelle, Cecilia Lindgren, Konstanze Stangner, Sofie Knutsson, Nina Forsgren, Fredrik Ekström, Luna Kamau, Anna Linusson JonssonVector control with insecticides is an important preventive measure against mosquito borne-infectious diseases, such […]Rajeshwari Choudhary
- Recent Developments in the Discovery of Indole-based Scaffolds as Promising Targeted Cancer Therapeutics November 18, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00849B, Review ArticlePrasanna Anjaneyulu Yakkala, VENKATESH ERRAM , Sajeli A. Begum, Ahmed KamalCancer remains a leading cause of mortality worldwide, driving the need for new and more effective therapeutics. Indole-based scaffolds have emerged as highly versatile structural frameworks in drug discovery in...The content of this RSS Feed (c) The […]Prasanna Anjaneyulu Yakkala
- Design and evaluation of an HSP70-targeting PROTAC in synergy with an HSF1 inhibitor for enhanced antitumor activity November 18, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00726G, Research ArticleWei-Hao Huang, Teng-Yu Mao, Guo-Yao Dai, Jian-Mei Ye, Jia-Bao Li, Shuo-Bin Chen, Jia-Heng Tan, Zhi-Shu Huang, Shi-Liang HuangCombining novel non-ATP site HSP70-targeting PROTACs with HSF1 inhibitor DTHIB disrupts heat shock feedback loop, enhancing HSP70 degradation and synergistically suppressing tumor viability.To cite this article before page numbers are […]Wei-Hao Huang
- Discovery and Optimization of Pyrrolopyrimidines as Highly Potent, Selective and Brain-Penetrant LRRK2 Inhibitors November 17, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00856E, Research ArticleJeffrey Axten, Xiao Ding, Luigi Stasi, Baowei Zhao, Yingxia Sang, Ming-Hsun Ho, Lizhen Wang, Minhua Zhang, Xianjun Guo, Chengfang Tan, Xu Feng, Colin Edge, Klara L. Valko, Yi Li, Kelly Dong, Xiaoming Guan, Nico Zinn, F David Tattersall, Feng Ren, Dai-Shi Su, Alastair D ReithLeucine-rich repeat kinase […]Jeffrey Axten
- Novel Pyrido[2,3-b][1,4]oxazine-Based EGFR-TK Inhibitors: Rational Design and Synthesis of Potent and Selective Agents Targeting Resistance Mutations in Non-Small Cell Lung Cancer November 14, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00861A, Research ArticleVaibhav B. Yadav, Shailee Tiwari, S. Hemant Kumar, Santosh Rangnath DeshmukhSeveral first-, second-, and third-generation EGFR-TKIs have proven effective as anti-cancer therapeutics. However, the rapid development of drug resistance and mutations continues to be a major challenge in EGFR-TKI therapy....The content of this RSS Feed (c) The […]Vaibhav B. Yadav
- 2-Oxoindolin-thiazoline hybrids as scaffold-based therapeutics for T2DM-associated cognitive impairment: design, synthesis, in vitro and in silico studies November 14, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00628G, Research ArticleWesam S. Qayed, Mostafa A. Hassan, Halil Şenol, Parham Taslimi, Tarek Aboul-FadlDesign and evaluation of 2-oxoindolin/thiosemicarbazone–thiazoline hybrids as dual antidiabetic and anti-alzheimer agents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Wesam S. Qayed
- Diversifying the Triquinazine Scaffold of a Janus Kinase Inhibitor November 13, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00921A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kleni Mulliri, Kris Meier, Johanna-Dorothea Feuchter, Sacha Javor, Matheus Andrade Meirelles, Jean-Louis ReymondThe exploration of novel three-dimensional scaffolds remains essential for expanding chemical space and discovering new bioactive molecules. Here, we describe […]Kleni Mulliri
- Peripheral Tailoring of Pentacene: Developing Next-Generation Organic Sonosensitizers for Cancer Sonodynamic Therapy November 13, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00851D, Research ArticleNan Han, Yu Zhang, Chunyuan Hou, Jun Gu, Jun LuoSonodynamic therapy (SDT) is an innovative, non-invasive, and effective method for cancer treatment. However, exploring sonosensi-tizers with high sonosensitivity and biosafety remains a significant challenge. Recent investigations have demonstrated that...The content of this RSS Feed (c) The Royal […]Nan Han
- The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition. November 22, 2025
