RSC – RSC Med. Chem. latest articles- Targeting DNA-PK: medicinal chemistry insights into small-molecule inhibitor discovery and optimisation June 7, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00119J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elle Watson, Jack R. R. Hutchinson, Suzannah J. Harnor, Luke Gaughan, Celine CanoSince Wortmannin's discovery, DNA-PK inhibitors have expanded to optimised scaffolds, including chromen-4-ones (e.g. NU5455) and purinones (e.g. AZD7648). This review […]Elle Watson
- Novel Hydroxytyrosol Esters as Potential Anti-Amyloid and Neuroprotective Agents for Alzheimer's Disease June 3, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00265J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ioanna Kalpaktsi, Anthi Panara, Barbara Mavroidi, Garcia Niforos, Amalia D Kalampaliki, Ioanna C Vlachogianni, Eleftheria A Georgiou, Elizabeth Fragopoulou, Anthony Tarbopoulos, AL Skaltsounis, Maria Pelecanou, K Palikaras, Evagelos Gikas, Ioannis K. KostakisAlzheimer's […]Ioanna Kalpaktsi
- Synthesis, molecular modelling and evaluation of (-)-isopulegolbased 2,4-diaminopyrimidines as promising Aurora kinase inhibitors June 2, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00278A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tam Minh Le, Nikoletta Szemerédi, Gabriella Spengler, Minh Canh Nguyen, Huynh Nguyen Khanh Tran , Khac-Minh Thai, Zsolt SzakonyiA library of (-)-isopulegol based 2,4-diaminopyrimidines was prepared from commercially available (-)-isopulegol. Aminodiols, derived […]Tam Minh Le
- Novel Urea- and Piperazine-Functionalized Alepterolic Acid Derivatives: Synthesis, Anticancer Activity, and Mechanism of Action June 2, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00275G, Research ArticleBinbin Zhang, Yating Jia, Siyu Qiu, Yanchun Sun, Lian Ma, Peixin Wang, Zixuan Tong, Fengjiao Wang, Guozheng Huang, Jianguo CaoLung cancer remains the leading cause of both cancer incidence and mortality worldwide, rendering it a primary focus in oncology research. This pressing global health challenge has created […]Binbin Zhang
- A Bakuchiol-Linked Tetrazole Exhibits Narrow-spectrum Activity Against Streptococcus pneumoniae June 1, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00230G, Research ArticleNeha Sengar, Vidyadhar Pratap, Tuhin Sarkar, Vishnu Kriplani, Astha Gupta, Sanjay Mandal, Prasad V. Bharatam, Dulal Panda, Inder Pal SinghNatural product-based amphiphilic phenolic terpenoid antimicrobial agents were rationally designed by integrating the meroterpenoid bakuchiol with a tetrazole moiety through a fragment-based drug design strategy. A library of […]Neha Sengar
- 3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors May 31, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00285D, Research ArticleMuhammad Syafiq Bin Shahari, Jacob P Mahoney, Ziyue Wang, Anil Pant, Ajit Jagtap, Roshan Katekar, Jiashu Xie, Zhilong Yang, Zhengqiang WangHolliday junction resolvase plays an important role in poxvirus genome replication and viral maturation. Recently, we developed the first in vitro assay measuring the activity of orthopoxvirus […]Muhammad Syafiq Bin Shahari
- Bismuth drug as antibiotic adjuvant to inhibit biofilm formation via a dual mechanism May 27, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00204H, Research ArticleJingru Li, Peng Gao, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe SunBurkholderia cepacia (B. cepacia) exhibits intrinsic resistance to many conventional antibiotics. A key factor contributing to this resistance is its ability to form biofilms, which hinder antibiotic penetration and make...The content of this RSS Feed (c) The […]Jingru Li
- Solvent and Catalyst-Free Mechanochemical Synthesis of Indenyl-Derived Thiazolone imine, Thiazolidin-4-one and Thiazolidin-4-ol Hybrids: Anticancer Evaluation and Molecular Modeling Studies May 27, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00178E, Research ArticleSanket Shantaram Mohite, Vikas Madhukar Bangade, Ambareen Shaikh, Bhushan Bhagwantrao PopatkarTo shed light on the significance of indenyl-derived thiazole derivatives in the advancement of cancer medication and to contribute to therapeutic innovation, we wish to disclose a facile, effective and...The content of this RSS Feed (c) The […]Sanket Shantaram Mohite
- Design, synthesis, in-silico and in-vitro evaluation of Novel Complex Naphthalimide-Ciprofloxacin Hybrids as next-generation antimicrobial agents May 25, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00193A, Research ArticleArunava Manna, Dharmendra singh, Ankita Singh, Harikesh Kumar Gupta, Sajida Banoo, Sumit Maurya, Vishwakarma Krishna Ramesh, Khushbu Khushbu, Ambrish Kumar, Jyoti Kumari, Avisek Mahapa, Shruti Trivedi, Rajnish Kumar, Shashikala Verma A series of ciprofloxacin-naphthalimide hybrid drugs as novel antibacterial agents were synthesized and screened for their antibacterial […]Arunava Manna
- Twenty Years of Quinazolines as Tubulin Polymerisation Inhibitors May 24, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01035G, Review ArticleNicholas O'Brien, Adam McCluskeyOver the past two decades, the quinazoline scaffold has emerged as a privileged framework in the development of small molecule tubulin polymerisation inhibitors. Here we map the chemical space of...The content of this RSS Feed (c) The Royal Society of ChemistryNicholas O'Brien
- Targeting DNA-PK: medicinal chemistry insights into small-molecule inhibitor discovery and optimisation June 7, 2026
