RSC – RSC Med. Chem. latest articles- Bicyclic Monoterpenoid-Based Orthopoxvirus Inhibitors: Design, Synthesis, and Biological Assessment of a Novel Amide Series April 8, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00217J, Research ArticleSerafim A Tishchenko, Anastasiya Sokolova, Valeriya V Samsonova, Julia G Pushkareva, Daria E Solomina, Olga I Yarovaya, Nikolay I. Bormotov, Ivan A. Moskalev, Artem Rogachev, Alina Fatyanova, Sophia Borisevich, Olga Serova, Alena Ovchinnikova, Larisa Shishkina, Alexander Agafonov, Artemiy Sergeev, Nariman Salakhutdinov, Alexander SergeevThis study reports the design, […]Serafim A Tishchenko
- Recent advances towards BACE1 drug discovery and therapeutics design April 8, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01095K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Saim Imran, Meera Patel, Meissam Noroozifar, Kagan KermanAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. A key feature of AD is the accumulation of amyloid […]Saim Imran
- A Comprehensive Study of Novel Pregnenolone-Isoxazole Hybrids as Selective Inducers of Mitochondrial Apoptosis in Breast Cancer Cells April 7, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00076B, Research ArticleVictoria Malakhova, Alexander Scherbakov, Diana I. Salnikova, Alvina Khamidullina, Danila Sorokin, Dmitry A. Vasilenko, Elena Chernoburova, Elena Averina, Igor V. Zavarzin, Yulia VolkovaHeterocyclic derivatives of steroids have emerged as promising anticancer agents by concurrently targeting multiple pathways, including apoptosis induction, cell cycle arrest, and mitochondrial dysfunction. Here, […]Victoria Malakhova
- Quinoline/Thiazole Compounds as Selective Acetylcholinesterase Inhibitors: Synthesis and Biological Assessment April 6, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00165C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Berkant Kurban, Derya Osmaniye, Serkan Levent, Yusuf Ozkay, Zafer Asim KaplancikliAcetylcholine (ACh), acetylcholinesterase enzyme (AChE), and AChE inhibition are of great importance in the treatment of neurodegenerative diseases. When it comes to […]Berkant Kurban
- Redefining the role of the thiol-based agent N-acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative March 31, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01173F, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hui-Qi Qu, Charlly Kao, Hakon HakonarsonN-Acetylcysteine amide (NACA) reduces polarity and ionization relative to NAC, improving membrane permeability and intracellular exposure while preserving thiol-mediated redox activity and glutathione support.To cite this article […]Hui-Qi Qu
- Novel zerumbone-amide-triazole hybrids as potential NF-κB pathway inhibitors: design, synthesis, cytotoxicity evaluation, computational studies, and mechanistic insights March 26, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00148C, Research ArticleChinh The Pham, Thi Tham Pham, Lien Thi Vu, Nhung Thi Dao, Loan Thi Thuy Le, Khieu Thi Tam, Vu Tuan Kien, Cao Thanh Hải, Thanh Phuong Phan, T. T. Thao, Truong Xuan Vuong, Le Thi LienA series of fifteen novel zerumbone-amide-triazole hybrids 12a-i and 15a-f were […]Chinh The Pham
- Design, Synthesis, and Biological Evaluation of Quinoline Derivatives as Dual-target Inhibitors of Chitin Synthase and Glucosamine-6-Phosphate Synthase March 26, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01001B, Research ArticleNan Wang, Lige Liu, Tao Liu, Hong Luo, Yan Long, Xinglong Yang, Youli Zhang, Qinggang JiTwo series of compounds were designed and synthesized based on a glycine methyl ester-quinoline core scaffold combined with a fragment containing nitrogen using either an isoxazole or a piperidine carboxamide...The content of […]Nan Wang
- D-Galactose-conjugated pyrimidine thioureas as potent antimicrobial agents: rapid green synthesis, structure-activity relationships and molecular modelling March 25, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00026F, Research ArticleNguyen Dinh Thanh, Vu Ngoc Toan, Ngo Hong Anh Thu, Nguyen Minh Tri, Duong Ngoc Toan, Hoang Thi Kim VanA series of D-galactose-conjugated pyrimidine-based thioureas 8a-l was efficiently synthesized using an environmentally benign ionic liquid-microwave protocol. Optimal conditions employing [BMIM][BF4] under microwave irradiation (100 W) afforded excellent […]Nguyen Dinh Thanh
- Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis March 23, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01046B, Research ArticleRongbin Wei, Xin Wang, Yamin Ding, Suting Zhu, Richmond Kwame Frimpong Asiedu, Muzi Li, Haitao Qian, Yifei Gu, Bailing JiangCompound Q-11 shows potent nanomolar antiproliferative activity in gastric cancer cells and induces ROS accumulation, mitochondrial dysfunction and cytoskeletal disruption.To cite this article before page numbers are assigned, […]Rongbin Wei
- The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles March 23, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00091F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pinky K. Naicker, Mariam Yacoub, Lisa J. White, Dominick E. Balderston, Perry A. Hailey, J. Mark Sutton, Charlotte K. Hind, Jennifer R. HiscockThe use of bioisosteres enhances the antimicrobial activity for a […]Pinky K. Naicker
- Bicyclic Monoterpenoid-Based Orthopoxvirus Inhibitors: Design, Synthesis, and Biological Assessment of a Novel Amide Series April 8, 2026
