RSC – RSC Med. Chem. latest articles- In Vivo Demonstration of Enhanced mRNA Delivery by Cyclic Disulfide-Containing Lipid Nanoparticles for Facilitating Endosomal Escape June 26, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00084J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Seigo Kimura, Kana Okada, Noriaki Matsubara, Fangjie Lyu, Susumu Tsutsumi, Yasuaki Kimura, Fumitaka Hashiya, Masahito Inagaki, Naoko Abe, Hiroshi AbeCurrent LNP technology faces challenges that must be addressed to enhance the functionality […]Seigo Kimura
- Bioassay-Guided Isolation of Hepatoprotective Lignans from Vernonia cinerea: DeepSAT-Driven Structural Elucidation and Predictive Mechanistic Insights Against Drug-Induced Liver Injury June 25, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00331H, Research ArticleMu Li, Meng Ke Zhang, Xin Song, Yu-Ting Zhong, Ming-An Gui, Jie Ping, You-Sheng Cai, Ruiying YuanThree new dibenzylbutane lignans, vernolignans A−C (1−3), along with three known compounds (4−6), were isolated from Vernonia cinerea through a bioactivity-guided isolation process. The planar structures of the new compounds...The content […]Mu Li
- Synthesis and biological evaluation of thiosemicarbazone-based antibody–drug conjugates June 25, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00154D, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nandan Sheernaly, Irene Shajan, Axel Steinbrueck, Bauke Albada, Nils Metzler-Nolte2-Dipyridyl-3-thiosemicarbazones were conjugated to trastuzumab via ortho-quinone cycloaddition and azide–alkyne click chemistry. The novel ADCs showed intriguing cell-line dependent activity, with the payload […]Nandan Sheernaly
- 5-(Thiophen-2-yl)isoxazoles as novel anti-breast cancer agents targeting ERα: Synthesis, in vitro biological evaluation, in silico studies, and molecular dynamics simulation June 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00339C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Paramita Pattanayak, nikhitha sripathi, DEBOJYOTI HALDER, Balaram Ghosh, Tanmay ChatterjeeHerein, we report the design and synthesis of novel 5-(thiophen-2-yl)-4-(trifluoromethyl)isoxazoles (TTI), and in-vitro evaluation of their anti-cancer activities. Based on the molecular structure […]Paramita Pattanayak
- ATP-competitive inhibitors for cancer treatment – kinases and the world beyond June 24, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00235D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ana Jug, JANEZ ILAŠAdenosine 5′-(tetrahydrogen triphosphate) (ATP), an essential molecule for cellular energy transfer, plays a crucial role in various biochemical processes, including protein folding, DNA repair and intracellular signalling. A promising […]Ana Jug
- A Review on Small Molecular Mimics of Antimicrobial Peptides with An Emphasis on Structure-Activity-Relationship Perspective June 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00407A, Review ArticleSanghamitra Das, Raghav Poudel, Kalyan Dutta, Mohini Mohan KonaiA rapid emergence of antibiotic resistance in bacteria has brought forth an alarming situation in the face of public health, is a huge cause of concern around the globe. In...The content of this RSS Feed (c) The Royal Society […]Sanghamitra Das
- Novel mangiferin derivatives attenuate adipogenesis in 3T3-L1 preadipocytes and ameliorate diet induced obesity in C57BL/6J mice June 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00264H, Research ArticleDong-Quan Gu, Yin Li, Liu-Shun Wu, Meng-Ting Lyu, Ying Li, Sheng-Zhuo Huang, Feng-Qing Xu, Deling Wu, Wu-Xi ZhouMangiferin with a xanthone scaffold exhibited potent anti-obesity activities and thus have attracted interest. However, some shortcomings, including limited solubility and moderate potency, restrict its application. To develop novel and...The […]Dong-Quan Gu
- A Glimpse into the Developments, Potential Leads and Future Perspectives of Anticancer Cobalt Complexes June 23, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00323G, Review ArticleAzharudin Khursheed, Nuzhat Khursheed, Nusrat Rashid, Waheed Ahmad Khanday, Afzal Hussain, Mohamed F. AlAjmi, Samira Amir, Akhtar Hussain Malik, Jahangir Ahmad Rather, Abdul Haleem Wani, Jahangir Ahmad, Iqbal Hussain, Prince Firdous Iqbal, Waseem A. WaniThe unanticipated finding of cisplatin’s anticancer properties spurred myriad investigations into different platinum […]Azharudin Khursheed
- Structure-based design and evaluation of tyrosinase inhibitors targeting both human and mushroom isozymes June 22, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00357A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Salvatore Mirabile, Giovanna Pitasi, Sonia Floris, Kristina Schira, Lyna Khettabi, Montserrat Soler-Lopez, Jörg Scheuermann, Rosaria Gitto, Maria Paola Germanò, Antonella Fais, Laura De LucaTyrosinase inhibition represents an attractive challenge to fight skin […]Salvatore Mirabile
- Syntheses and preclinical evaluations of 11C-labeled radioligands for imaging brain orexin-1 and orexin-2 receptors with positron emission tomography June 19, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00382B, Research ArticleSusovan Jana, Pooyeh Ahmadi, Xuefeng Yan, Ping Bai, Jeih-San Liow, Adrian E. Jenson, Matilah T. Pamie-George, Sami S. Zoghbi, Shawn Wu, Changning Wang, Robert B. Innis, Victor W. Pike, Sanjay Telu[11C]GSK1059856 and [11C]ET1 were prepared as candidate radioligands for PET imaging of brain OX1R and OX2R, respectively […]Susovan Jana
- In Vivo Demonstration of Enhanced mRNA Delivery by Cyclic Disulfide-Containing Lipid Nanoparticles for Facilitating Endosomal Escape June 26, 2025
