RSC – RSC Med. Chem. latest articles- Understanding the HIV-CA Protein and the Ligands that Bind at the N-Terminal Domain (NTD)- C-Terminal Domain (CTD) Interface April 16, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00111K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stuart LangTreatment and prevention of HIV/AIDS infections represents a significant global challenge, with this being the cause of a substantial number of deaths each year. HIV-CA, the protein responsible for protecting...The content […]Stuart Lang
- Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer April 16, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00086F, Research ArticleAya Fathy, Amro Allam, Ahmed K. ElHady, Dalia S. El-Gamil, Kai-Chun Lin, Yen-Hua Chang, Yu-Hsuan Lee, Sebastian Hilscher, Mike Schutkowski, Hany S. Ibrahim, Shun-Hua Chen, Chun-Hong Chen, Ashraf H. Abadi, Wolfgang Sippl, Po-Jen Chen, Yi-Sheng Cheng, Mohammad Abdel-HalimOverexpression of histone deacetylase 6 (HDAC6) is implicated in tumorigenesis, […]Aya Fathy
- New acridone derivatives to target telomerase and oncogenes – an anticancer approach April 16, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00959B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tiago J. S. Marques, Diana Salvador, Helena Oliveira, Vanda V. Serra, Nicholas Paradis, Chun Wu, Vera L. M. Silva, Catarina I. V. RamosG4 stabilization by acridone derivatives to indirectly regulate pancreatic cell […]Tiago J. S. Marques
- Lock and key: Locked G quadruplexes could be the key to new modalities in nucleic acid therapeutics April 16, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00142K, OpinionNishant Nitinidhi Kulshreshtha, Philippe BarthelemyG quadruplexes are secondary structures formed by G-rich sequences in DNA/RNA. They are critical regulatory centres for gene activation and chromosome stability. Malfunctions in their number or topology often results...The content of this RSS Feed (c) The Royal Society of ChemistryNishant Nitinidhi Kulshreshtha
- Design and development of sulfenylated 5-aminopyrazoles as inhibitors of acetylcholinesterase and butyrylcholinesterase: exploring the implication for Aβ1–42 aggregation inhibition in Alzheimer's disease April 16, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00069F, Research ArticlePayal Rani, Sandhya Chahal, Anju Ranolia, Kiran, Devendra Kumar, Ramesh Kataria, Parvin Kumar, Devender Singh, Anil Duhan, Vibhu Jha, Muhammad Wahajuddin, Gaurav Joshi, Jayant SindhuSulfenylated amino pyrazoles: inhibitors of acetylcholinesterase and butyrylcholinesterase.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Payal Rani
- Synthesis, characterization and biological activity of methotrexate-derived salts in lung cancer cells April 15, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4MD00960F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dário Silva, Sandra Cordeiro, Pedro V Baptista, Alexandra R Fernandes, Luis C BrancoLung cancer is the deadliest type of cancer remaining a public health problem worldwide. Methotrexate (MTX) as class IV drug […]Dário Silva
- Razing the Scaffolding: The Elimination of Non-Catalytic Functions of Kinases through Targeted Protein Degradation April 14, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00095E, Review ArticleSarah Pogash, Steven FletcherOverexpression and activation of kinases often results in cancer initiation and progression through both catalytic and non-catalytic functions by promoting rapid proliferation, growth, survival, and metastasis of cells. Catalytic functions...The content of this RSS Feed (c) The Royal Society of ChemistrySarah Pogash
- Rutaecarpine derivatives synthesized via skeletal reorganization alleviate inflammation-associated oxidative damage by inhibiting the MAPK/NF-κB signaling pathway April 13, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD01022A, Research ArticleNan-Ying Chen, Cai-Neng Zhang, Xiu-Yun Guo, Liu-Song Lan, Yi-Fan Geng, Jin-Hui Peng, Cheng-Xue Pan, Yan Huang, Gui-Fa SuIn recent years, skeleton reorganization based on bioactive natural products has emerged as a novel alternative strategy to the classical approach, mainly focusing on the peripheral modification of the inherent […]Nan-Ying Chen
- Combating oxi-inflamm-aging: Passerini adducts tethered with 1,2,3-triazoles for enhanced antioxidant defense and 5-LOX inhibition April 13, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D4MD00981A, Research ArticleMohammed Salah Ayoup, Marwa Mohammed Rashwan, Saied M. Soliman, Doaa A. Ghareeb, Samah Ashraf, Magda M. F. Ismail, Gina N. Tageldin, Amr Sonousi, Laila F. AwadDesign and synthesis of novel hybrids of Passerini adducts tethered with 1,2,3-triazoles as promising dual anti-inflammatory and antioxidant agents.To cite this article […]Mohammed Salah Ayoup
- Design, Synthesis and Anti-proliferative Activity of 3-Aryl-Evodiamines April 13, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00179J, Research ArticleMing-Li Zhou, Nan-Ling Liu, Lian Sun, Xiao-Huan Li, Jin-Bu Xu, Feng GaoEvodiamine and its analogues have received significant attention due to their antitumor activity. In this work, Pd catalyzed Suzuki-Miyaura coupling was employed as key reaction to diversify at C3 position...The content of this RSS Feed (c) […]Ming-Li Zhou
- Understanding the HIV-CA Protein and the Ligands that Bind at the N-Terminal Domain (NTD)- C-Terminal Domain (CTD) Interface April 16, 2025
