RSC – Org. Chem. Front. latest articles- Iridium-Catalyzed Asymmetric Allenylic Substitution of Tertiary Racemic Allenylic Alcohols with Indoles November 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01671H, Research ArticleTakahiro Sawano, Manami Kobayashi, Momoko Ishikawa, Eri Ishikawa, Ryo TakeuchiWe report an allenylic substitution of racemic tertiary allenylic alcohols with indoles by a cooperative catalyst consisting of iridium/(P, olefin)-ligand catalyst and Lewis acid to give allenylated indoles bearing a...The content of this RSS Feed (c) The Royal […]Takahiro Sawano
- Synthesis and derivatization of an isomer of N-heterotriangulene bearing five-, six- and seven-membered rings around the central nitrogen atom November 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02027H, Research ArticleXinxin Chen, Weifan Wang, Gang ZhangThe functionalization of N-heterotriangulenes has been extensively investigated for their potentials as optoelectronic materials. However, study on the influence of molecular geometry on the property of N-heterotriangulene is still rare....The content of this RSS Feed (c) The Royal Society of ChemistryXinxin Chen
- Brønsted Acid-Catalyzed Solvent-Controlled Regioselective Thiolation of 2-Furylcarbinols November 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01904K, Research ArticleChunyu Zhang, Tianyu Lin, Qing Liu, Rui Hu, Weidong RaoA novel p-toluenesulfonic acid-catalyzed solvent-controlled regioselective thiolation of 2-furylcarbinols for the efficient and chemoselective preparation of densely functionalized furan- and lactone-based sulfides under mild metal-free conditions has been developed. By...The content of this RSS Feed (c) The Royal […]Chunyu Zhang
- Photoinduced Ullmann-Type Cross-Coupling Reactions: Mechanistic Insights and Emerging Challenges November 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01814A, Review ArticleAhmed Th Abdulghaffar, Hao-Long Zhang, Qiankun Zhang, Qian Tong, Ruirui Tian, Hao Xu, Jiawei Yang, Yuanqing XuPhotoinduced Ullmann-type cross-coupling reactions have become a significant advancement in organic synthesis, providing an efficient means to form C–C and C–heteroatom bonds under milder, light-driven conditions. Utilizing copper catalysis, these...The content […]Ahmed Th Abdulghaffar
- (BO)2-doped tetrathia[7]helicenes: synthesis and properties-change induced by “BO bonds inversion” November 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01897D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Luigi Menduti, Clara CB Baldoli, Michael Bolte, Simone Manetto, Claudio Villani, Marta Penconi, Sara Grecchi, Serena ARNABOLDI, Giuseppe Mazzeo, Giovanna Longhi, Alexander Virovets, Hans-Wolfram Lerner, Matthias Wagner, Emanuela LicandroHelical distortion of polyaromatic […]Luigi Menduti
- Direct Aminosulfonylation of Electron-rich (hetero)Arenes Utilizing tert-Butyl Chlorosulfonylcarbamate with Diisopropylethylamine November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01731E, Research ArticleXiaofei Zhang, Jiangtao Tan, Yuanchen Zhong, Zhen Zhuang, Qian He, Min Jiang, Chunhao YangSulfonamides, especially primary aryl sulfonamides are very important scaffolds not only because of the wide applications as pharmacophores in drugs, but also the derivatization for other sulfonamides and different sulfur-containing...The content of this RSS […]Xiaofei Zhang
- Ligand-Controlled Rh(I) -Catalyzed Intramolecular Alkyne Sila-Cyclization: Divergent Catalysis and Mechanistic Studies November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02119C, Research ArticleWei-Ke Zhu, Jia-Wei Si, Sui-Fang Peng, Li Li, Fei Ye, Zheng Xu, Li-Wen XuThe synthesis of structurally diverse silacycles is crucial for the silicon-containing drug and agrochemical development. However, catalytic synthesis of dense-functionalized silacycles that based on selectively cleavage and reconstruction of the...The content of this RSS […]Wei-Ke Zhu
- Lewis Acids Catalyzed Regiodivergent N-alkylation of Indazoles with Donor-Acceptor Cyclopropanes November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01493F, Research ArticleXiaoyan Zhang, Yujiao Xiang, Xiangyang Zhao, Xin Zhou, Weiliang Chen, Yungui PengN-alkyl Indazoles are highly privileged skeleton in pharmaceutical applications. Generally, N1 and N2-alkyl indazoles represents distinct pharmaceutical and biological activities due to their molecular shape and electrostatic distribution. Herein, we...The content of this RSS Feed (c) […]Xiaoyan Zhang
- Catalyst-Free Synthesis of Unsymmetrical ureas from COS and Amines: a Strategy for Selectivity Regulation November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01553C, Research ArticleSiliu Cheng, Yunzhe Du, Huijie Jia, Shuyi Li, Yian Feng, Ning ZhuA novel and mild method for the highly selective synthesis of asymmetric urea from amines and COS has been established. This method effectively synthesizes asymmetric urea from combinations of aliphatic...The content of this RSS Feed (c) […]Siliu Cheng
- N-Aryl/Heteroaryl Oxaziridines: From Photochemical Synthesis to Reactivity Investigation in Heteroatom Transfer Reactions November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01758G, Research ArticleBao-Gui Cai, Hui Mao, Kun Wang, Jun XuanThe reactivity of oxaziridines is significantly influenced by the substituents on the nitrogen atom. Despite extensive studies since their discovery by Emmons in 1956, research on the reactivity of N-aryl/heteroaryl...The content of this RSS Feed (c) The Royal Society of […]Bao-Gui Cai
- Viologen–Cycloparaphenylene Hybrids: Luminescent Molecular Nanocarbons for Anion Binding and Specific Vapor Sorption† November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01993H, Research ArticleMarcin Stępień, Rafał Frydrych, Kabali Senthilkumar, Katarzyna Ślusarek, Mateusz Waliczek, Wojciech Bury, Piotr J. Chmielewski, Joanna CybińskaTwo viologen-like macrocyclic receptors, [1]2+ and [2]2+, merging a bent oligophenylene loop with a (para-xylylene)bispyridinium moiety were designed and synthesized. Both dications were derived from the same precursor: the more...The content […]Marcin Stępień
- Catalytic enantioselective and site-specific Friedel−Crafts alkylation of 4-aminoindoles with β,γ-alkynyl-α-ketoimines for the synthesis of C7-functionalized indoles November 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01856G, Research ArticleLei Yang, Xue-Man Zhang, Juan Liao, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, Jian-Qiang Zhao, Wei-Cheng YuanChiral phosphoric acid-catalyzed enantioselective Friedel−Crafts alkylation of 4‑aminoindoles with β,γ-alkynyl-α-ketoimines has been developed. A range of optically pure C7-functionalized indoles bearing a quaternary α-amino acid or trifluoromethylated tetrasubstituted alkylamine motif...The content of […]Lei Yang
- Deuterium Exchange of Pyrrolic NH Protons Accelerated by Fluoride and Bicarbonate in CDCl3, CD3CN, and DMSO-d6 November 18, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01855A, Research ArticleSung Kuk Kim, Nam Jung Heo, Ju Hyun Oh, Jonathan L. SesslerThe anion binding features of pyrrole- and benzene-strapped calix[4]pyrroles 1 and 2, in particular, for F– and HCO3– have been examined by means of NMR spectroscopy in DMSO-d6, CDCl3, and...The content of this RSS Feed (c) […]Sung Kuk Kim
- Chiral CpxRhIII-Catalyzed Enantioselective C-H Annulation to Access Fused Tricyclic Sulfur-Stereogenic and Medium-sized aza-Heterocycles November 15, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01749H, Research ArticleYuping Xiong, Muhammad Suleman, Shujuan Xu, Zhiyuan ChenWe report herein a chiral CpxRhIII-catalyzed asymmetric sp2 C-H bond activation/annulation reaction of free NH-sulfoximines with hypervalent iodonium ylides under external ligand-free conditions was reported. Efficient kinetic resolution (KR) was...The content of this RSS Feed (c) The Royal Society of […]Yuping Xiong
- Hierarchical Supramolecular Assembly based on Metal Coordination of Asymmetric Ligand Pairs and Host-Guest Recognition November 15, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01926A, Research ArticleHui Li, Yan Dong, Riqiang Li, Yan Zhang, Shengyong Liu, Wei TianThree distinct monomers were synthesized, namely CD2, E2, and F2. Monomer CD2 is composed of a crown ether group (B21C7) and two terpyridine (tpy) groups, monomer E2 contains two 6,6"-di(2,6-dimethoxylphenyl)-substituted...The content of this RSS Feed (c) […]Hui Li
- Iridium-Catalyzed Highly Enantioselective and Chemodivergent Coupling Reaction of Vinyl Azides and Vinyl Benzoxazinones November 15, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01862A, Research ArticleDeli Gan, Sumei Zhao, Min Yang, Minghui Xu, Bin Chen, Wenhao Yu, Hai-Liang Ni, Bi-Qin Wang, Ping Hu, Peng CaoThe first Iridium-catalyzed enantioselective coupling reaction of vinyl azides and vinyl benzoxazinones is presented. Vinyl azides underwent a tandem allylic alkylation/interrupted Schmidt rearrangement process to produce enantioenriched 3,4-dihydroquinolin-2(1H)-imines, […]Deli Gan
- Visible Light-Mediated [1+2+2] Cycloaddition Reaction of Nitroarenes and Alkenes November 14, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01418A, Research ArticleMengxin Li, Molai Zhao, Xianglin Zhong, Xiaoqing Wen, Xiang-Wei Liu, He Zhong Jiang, Rui Tan, Jiahong LiWe report a visible light-mediated [1+2+2] cycloaddition reaction between nitroarenes and alkenes, conducted under mild conditions, to synthesize isoxazolidines. This method operates without photocatalysts or transition metal catalysts. Mechanistic studies...The content […]Mengxin Li
- One-pot synthesis of 2,2′-biquinolines from aromatic amines using oxygen as an oxidant under metal-free conditions November 14, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01896F, Research ArticleYunfeng Liao, Hualan Gao, Hongrui Qi, Jia Chen, Chang Liu, Yanjun Xie, Weijie Zhang, Jiyong Deng, Bing Yi, Guo-Jun DengWe have developed an efficient method for the synthesis of unsymmetrical and symmetrical 2,2′-biquinolines under 55% HI-catalyzed conditions using oxygen as the oxidant and cheap and readily available […]Yunfeng Liao
- Ortho-allylation of anilines with vinylaziridines in hexafluoroisopropanol November 14, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01719F, Research ArticleJing-Jing Nie, Zhong-Xia WangTransition-metal-free reaction of N,N-dialkylanilines with 1-sulfonyl-2-vinylaziridines in hexafluoroisopropanol in air gave ortho-allylated anilines in moderate to excellent yields. The reaction also features mild reaction conditions, ortho-monoallylation selectivity, E-configurated C-C double...The content of this RSS Feed (c) The Royal Society of ChemistryJing-Jing Nie
- A visible light-mediated deoxygenation protocol for the synthesis of dipeptides, amides and esters without racemization November 14, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01945H, Research ArticleJi-Wei Ren, Qing-Long Tan, Jian Zuo, Yan-Fei Miao, Pan Zhang, Jing-Hui Sun, Yin-Feng HanA green and sustainable visible light-induced triphenylphosphine-promoted deoxygenation strategy to generate acyl radicals from commercially available amino acids was developed for the synthesis of dipeptides, amides and esters in good yields.To cite this article […]Ji-Wei Ren
- Iridium-Catalyzed Asymmetric Allenylic Substitution of Tertiary Racemic Allenylic Alcohols with Indoles November 20, 2024
