RSC – Org. Chem. Front. latest articles- Correction: Recent advances in catalytic asymmetric reactions of Morita–Baylis–Hillman adducts May 17, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO90035F, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xu-Hong Duan, Hui-Ru Du, Yong-Xing SongTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryXu-Hong Duan
- Electrochemically Driven Nickel Catalysis for Formal C-H Amination May 15, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00461J, Research ArticleGege Jiang, Yun Sa, Bingnan Wang, Duanyang KongThe C-H amination of arenes represents a streamlined approach to arylamines, yet most existing methods rely on preactivated nitrogen reagents or directing groups, limiting practicality and substrate generality. Herein, we...The content of this RSS Feed (c) The Royal Society of […]Gege Jiang
- Repurposing trichloroacetonitrile as a sustainable radical synthon for regiodivergent photocatalytic alkene amination May 15, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00456C, Research ArticleXinlin Wang, Zhikai Li, Jia Jin, Kui Zhang, Lingchao CaiPersistent endeavors have been dedicated to the synthesis of nitrogen-containing compounds, which hold paramount significance in biological processes and are indispensable in the realms of pharmaceuticals and advanced materials. Herein,...The content of this RSS Feed (c) The Royal […]Xinlin Wang
- Catalyst-Controlled Chemodivergent C-H Functionalization of 2-Pyridylthiophenes with Allylic Alcohols May 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00441E, Research ArticleGuibin Wan, Qiang Zhang, Ying Liu, Haowei Zeng, Taoyuan Liang, Shuangliang Zhao, Zhuan ZhangA catalyst-controlled chemodivergent C–H functionalization of 2-pyridylthiophenes using allylic alcohols as versatile coupling partners is reported. Modulation of the catalytic system enables selective access to two distinct reaction pathways from...The content of this RSS […]Guibin Wan
- Formal meta-Selective C–H Acylation of Pyridines via the Triplet State of Oxazinopyridine Intermediates May 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00478D, Research ArticleFan Gao, Yajing Bian, Shiqing Huang, Xiaoyu YanPyridines are privileged structural motifs in pharmaceuticals and bioactive molecules. The introduction of substituents or functional groups at the meta-position via direct C–H functionalization of pyridines remains a formidable challenge....The content of this RSS Feed (c) The Royal Society of […]Fan Gao
- Aluminium-Catalysed Carbonyl-Selective Hydrophosphinylation of α,β-Unsaturated Ketones May 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00397D, Research ArticleZiyuan Pang, Wen Dai, Xiaobo Yang, Xiaoli Ma, Hongping Zhu, Zhi YangAn aluminium-catalysed carbonyl-selective hydrophosphinylation of α,β-unsaturated ketones is reported herein. Among the synthesised Schiff-base-supported non-precious metal complexes, the aluminium hydride complex C1 exhibited outstanding catalytic activity. In contrast to conventional...The content of this RSS Feed (c) […]Ziyuan Pang
- A Streamlined Lithiation-Cyclization Strategy Unlocks Broad-Scope, Efficient Access to Chiral 3,4-Dihydroisoquinolones and Isoindolinones May 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00462H, Research ArticleWenjun Luo, Hehua Lin, Ruinan Zhang, Genwei Zhang, Shaobin Tang, Daohong Yu, Zhengwang Chen, Zhong-Xia Wang, Junliang ZhangChiral 3,4-dihydroisoquinolones and isoindolinones serve as important chiral building blocks in pharmaceutical and natural product synthesis. Herein, we have developed a simplified and straightforward strategy that enables rapid and scalable...The […]Wenjun Luo
- A Generalized Electrochemical Dehydrogenation Approach en route to α-Phosphorylated Amines May 13, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00588H, Research ArticleNayan Saha, Shana Chandran, Burkhard KönigGiven the widespread use of organophosphorus scaffolds in several disciplines, the formation of C(sp³)–P bonds is of fundamental importance. Direct access to α-phosphorylated amines still remains challenging, though, because conventional...The content of this RSS Feed (c) The Royal Society of ChemistryNayan Saha
- Photocatalytic Defluoroalkylation of Trifluoromethylaromatics with arylethylenes May 13, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00541A, Research ArticleShiyong Guan, Yiteng Zheng, Zihan Cai, Yuegang ChenWe present a novel fluorine atom transfer technique for the selective functionalization of robust C-F bonds in trifluoromethylated aromatic compounds. This approach employs neutral boron radicals to generate aryl difluoromethyl...The content of this RSS Feed (c) The Royal Society of […]Shiyong Guan
- Modular Multicomponent Cascade Synthesis of Benzo[b]thiophene-Fused N,O-Heterocycles from 1,2-Benzisothiazoles, Benzolactones and Aldehydes May 13, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00413J, Research ArticleLongzhi Lin, Jie Ren, Heying Chen, Shuang Liu, Chuanjun Song, Junbiao Chang, Yangang WuA modular, metal-free multicomponent cascade reaction for the synthesis of benzo [b]thiophene-fused seven-, or eightmembered N,O-heterocyclic compounds from 1,2-benzisothiazoles, benzolactones, and aldehydes has been developed. Notably, 1,2-benzisothiazoles were employed as...The content of this RSS […]Longzhi Lin
- A chiral multibrominated triangular macrocycle for modulating circularly polarized phosphorescence May 13, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00378H, Research ArticleYuluo Huang, Jianqiu Li, Ming-Ze Meng, Tuo-Yu Zhou, Xiao-Nian Xue, Huang Wu, Shanshan Cheng, Yu WangThis work developed a chiral triangular macrocycle and achieved tunable circularly polarized room-temperature phosphorescence (CP-RTP) from blue-green to deep-red through rigidification and intermolecular charge-transfer interactions.To cite this article before page numbers are […]Yuluo Huang
- Intramolecular through-space heavy-atom effect in multiresonant thermally activated delayed fluorescence emitters with [2.2]paracyclophane May 12, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00318D, Research ArticleYan Xu, Hassan Hafeez, Wenrui Wang, Ifor D. W. Samuel, Eli Zysman-ColmanThe heavy-atom effect (HAE) is a powerful strategy to enhance spin-orbit coupling (SOC) for accelerating reverse intersystem crossing (RISC) in multiresonant thermally activated delayed fluorescence (MR-TADF) emitters, which is relevant...The content of this RSS Feed (c) […]Yan Xu
- Conformational Features of N-Trifluoromethyl Amides and Thioamides May 12, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00428H, Research ArticleRyu Yamasaki, Yuta Nozaka, Ami Nagai, Ai Ito, Masatoshi Kawahata, Iwao OkamotoWe investigated the structural and conformational features of N-trifluoromethyl (N-CF₃) (thio)amides using X ray and VT NMR analyses. These compounds showed lower rotational barriers and generally reduced cis populations compared...The content of this RSS Feed (c) […]Ryu Yamasaki
- Selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00391E, Research ArticleShuoshuo Zhang, Haibin Xiao, Yanjun Wu, Yue Zhang, Ling Jin, Junhao Chen, Xiaolei Huangα-Trifluoromethylalkenes are pivotal scaffolds in pharmaceutical, agrochemical, and material science. Recent advances have focused on their defluorinative functionalization or hydrofunctionalization with carbon-or silicon-containing coupling partners. However, as a fellow group...The content of this RSS […]Shuoshuo Zhang
- Copper-Catalyzed Three-Component Spiroannulation: Modular Access to 1,3,7,8-Tetraazaspiro[4.4]nona-3,6-dienes via a Metal-Free and Subsequent Cu(II) Relay Strategy May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00309E, Research ArticleDong-Fang Jiang, Wei-Min He, Zhenjie Qi, Hao Dong, Zhou Jia, Tang Yutong, Xiong Xin, Min TangA continuous one-pot protocol involving a metal-free oxidative 5-exo-trig cyclization of β, γ-unsaturated hydrazones, followed by Cu(II)-catalyzed intermolecular [3+2] cycloaddition with oximes and nitriles, has been established. Over 90 examples...The content of […]Dong-Fang Jiang
- Palladium-Catalyzed Synthesis of Aryl phosphonates Using Sodium Hypophosphite May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00520A, Research ArticleShang-Dong Yang, Dang-Wei Qian, Shi-Peng Chen, Hai-Chen MaAryl phosphonates represent a class of crucial structural motifs widely embedded in pharmaceutical molecular frameworks. Conventional synthetic approaches typically rely on PCl₃ or P(O)Cl₃ as the phosphorus source, which face...The content of this RSS Feed (c) The Royal Society of […]Shang-Dong Yang
- Imidazolium-dithiocarboxylate zwitterions catalyzed synthesis of fully substituted spiro-glutarimides via [3+3] annulation of cyclopropenones May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00157B, Research ArticleQichao Zhang, Fang Zhang, Qi Wu, Lin He, Zhihua Cai, Guangfen DuAn organocatalytic [3+3] annulation reaction of cyclopropenones and cyclic β-ketoamides has been reported for the synthesis of fully substituted spiro-glutarimides. Under the catalysis of imidazolium-dithiocarboxylate zwitterions (NHC•CS2), cyclopropenones react with...The content of this RSS Feed (c) […]Qichao Zhang
- C-H Functionalization via Photo-and Electrochemistry in Flow: A Review May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00296J, Review ArticleBing-Yu Huang , Miaolin Ke, Ya-Jiao Zhang, Fener ChenThe direct activation and functionalization of C-H bonds represent a cornerstone of modern synthetic chemistry, aiming for step-and atom-economical routes to complex molecules. However, traditional methods often rely on stoichiometric...The content of this RSS Feed (c) The Royal Society […]Bing-Yu Huang
- Synergistic Interplay between Ligand and Metal-Centered Chirality in Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanols May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00471G, Research ArticleXueyuan Yan, Genping HuangDensity functional theory calculations were performed to investigate the Ir/CBL-catalyzed C(sp3)-H borylation of cyclopropanols. The computations indicate that the reaction follows an Ir(III)/Ir(V) catalytic cycle with six-and seven-coordinate intermediates, involving...The content of this RSS Feed (c) The Royal Society of ChemistryXueyuan Yan
- Recent advances in transition metal-catalyzed organic transformations using hemilabile P,P=O ligands May 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00360E, Review ArticleZhenming Zhang, He Yang, Wenjun TangBisphosphine monoxides (BPMOs) represent a distinctive class of hemilabile bidentate ligands featuring a trivalent phosphine as a soft coordination site combined with a hard coordination site in the form of...The content of this RSS Feed (c) The Royal Society of ChemistryZhenming Zhang
- Correction: Recent advances in catalytic asymmetric reactions of Morita–Baylis–Hillman adducts May 17, 2026
