RSC – Org. Chem. Front. latest articles- Redox-Neutral electrochemical Diazo Coupling: Controlled Synthesis of Olefins and Azines via modulating reaction conditions June 5, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00499G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abinash Mohapatra, Vikas TyagiWe report a metal-free, linear paired redox-neutral electrochemical diazo coupling that enables the controllable synthesis of olefins and azines by modulating reaction conditions. The protocol exhibits a broad substrate […]Abinash Mohapatra
- One stone two birds, diverse glycopeptides synthesis via radical Ullmann coupling from serine. June 5, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00586A, Research ArticleShuang Wang, Qiuju Zhong, Xinru Liang, Gao-Qiang Li, Mingyu YangABSTRACT: The synergistic integration of synthetic efficiency with structural diversity constitutes a paramount objective in modern glycopeptide chemistry, addressing a critical challenge in the development of bioactive peptide therapeutics. Herein,...The content of this RSS Feed (c) The Royal […]Shuang Wang
- Remote Asymmetric amination of Naphthalene-Blocked Alkynes with various amines June 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00609D, Research ArticleShi-Wu Li, Su XieIn this study, we rationally designed and successfully established a versatile copper-catalyzed divergent reaction system by employing alkynyl naphthalates as key substrates. This tunable catalytic strategy exhibits distinct and controllable...The content of this RSS Feed (c) The Royal Society of ChemistryShi-Wu Li
- Three-component synthesis of β-phostams June 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00590J, Research ArticleWenlong Tong, Chengzhuo Wang, Mengyao Zhang, Jiaxi XuReaction of ethyl diarylmethylphosphonochloridates, cinnamaldehydes, and lithium hexamethyldisilylamide (LiHMDS) directly accesses β-phostams in satisfactory to excellent yields with moderate to good diastereoselectivities. The reaction is a tandem sequence of the...The content of this RSS Feed (c) The Royal Society of […]Wenlong Tong
- Pd-Catalyzed Stereoselective Enol Ether Coupling toward C2-Branched Carbohydrates: Experimental and Computational Insights into Glycal-Controlled Diastereoselectivity June 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00511J, Research ArticleRam Pratap Pandey, Bindu Tiwari, Mursaleem Ansari, Nazar HussainC2-branched glycal derivatives are key structural motifs in numerous pharmaceuticals and biologically active molecules. Herein, we report a ligand-free, palladium-catalyzed stereoselective cross-coupling of readily accessible iodo-glycals with cyclic enol ethers,...The content of this RSS Feed (c) The Royal Society […]Ram Pratap Pandey
- Deaminative Trifluoromethylation of Alkyl Amines Enabled by Photoexcited Copper Complexes June 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00659K, Research ArticleXian Gong, Hu Du, Yingying Li, Weihang Miao, Shengqing Zhu, Lingling ChuThe direct conversion of abundant alkyl amines to high-value motifs remains highly desirable yet challenging in chemical synthesis. Herein, we disclose a photoinduced copper-mediated protocol for the deaminative trifluoromethylation of...The content of this RSS Feed (c) […]Xian Gong
- Metal-Free Photocatalyzed Difunctionalization of Pyridines via Oxazinopyridine Intermediates June 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00465B, Research ArticleYihan Zhang, Minjie Jiang, Lufang Liao, Meng Chen, Fangrui Wu, Hong Qin, Zheng FangC–H functionalization of pyridines holds significant importance in the fields of medicine, chemistry, and materials science. Due to the intrinsic electronic properties of pyridines, their C–H functionalization reactions face considerable...The content of this RSS […]Yihan Zhang
- Enantioselective Copper-Catalyzed Synthesis of Axially Chiral Deuterated Biaryl Ethers and Phenols from Cyclic Iodonium Salts June 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00531D, Research ArticleWei-Yuan Ma, Maorui Zhu, Zenghui Ye, Xi Zhang, Jian-Xing Xu, Fengzhi ZhangAxially chiral biaryl compounds hold significant value in medicinal chemistry and asymmetric catalysis, while the incorporation of a deuterated methoxy group can substantially improve the pharmacokinetic properties of these molecules....The content of this RSS Feed (c) […]Wei-Yuan Ma
- Highly Selective (Deuterated) Defluorinative Hydrogenation of Trifluoroacetamides June 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00467A, Research ArticleRuiqi Guo, Zhushuang Bai, Yue Chen, aiqin liu, Jingxiang Pang, Feng Gao, Yong LiThe (deuterium-labeled) difluoromethyl (-CF₂H) and monofluoromethyl (-CFH₂) groups play an important role in numerous pharmaceuticals and pesticides due to their unique properties. Achieving highly selective (deuterated) hydrodefluorination of inexpensive and...The content of this RSS […]Ruiqi Guo
- Manganese catalyzed chemoselective transfer hydrogenation of unsaturated esters switched by solvent June 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00533K, Research ArticleYin Guo, Lixian Wang, Xinyu Ge, Zaoliang Meng, Fang Wang, Yanqun Wang, Wei Sun, Qiangsheng SunWe report a solvent-switchable chemoselective transfer hydrogenation of α,β-unsaturated esters, employing an earthabundant manganese complex as catalyst and ammonia borane as hydrogen donor. Diverse unsaturated esters are efficiently converted to...The content of […]Yin Guo
- Thianthrenation-enabled metal-free heterodifunctionalization of unactivated alkenes with thiols and readily available N/O nucleophiles June 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00627B, Research ArticleLude Wang, Mengfan Wang, Jing Xiao, Xiumin Ge, Shunyu Tu, Chunya Li, Donghui Lan, Shuang-Feng YinThe 1,2-heterodifunctionalization of alkenes represents a powerful strategy for constructing valuable molecules. However, simple, green, and general methods for these transformations are still highly desirable. Herein, we report a thianthrenation-enabled...The content of […]Lude Wang
- Visible-Light-Mediated Radical Cascade Sulfonylation/Trifluoromethylation/Difluoromethylation of Activated Alkenes with Sulfinates towards γ-Carbolinone Derivatives June 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00410E, Research ArticleYu-Cai Tang, Qiumei Yin, Jianhua Shi, Weiming Xia, Jiaming Huang, Hongxing Ma, Beibei Shan, Jiale Liu, Yuan-Dao Chen, Wei-Min Heγ-Carboline scaffolds are key structural motifs in various natural products and pharmaceuticals. Herein, we report a novel visible-light-driven, Rose Bengal-catalyzed radical cascade cyclization of N-acryloylindole-3-carboxamides with sulfinates for […]Yu-Cai Tang
- Anchoring–migration strategy enables metal-free C2-selective cross-coupling of benzothiophenes June 2, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00503A, Research ArticleHong-Tao Deng, Wen-Ning Zhu, Chen Zhao, Xiao-Fei Liu, Ji-Rong HuangMetal-free anchoring–migration enables C2-selective benzothiophene coupling. This strategy leverages transient dearomatization to bypass transition-metal activation, offering an efficient route to couple (hetero)arenes and 1,3-diketones.To cite this article before page numbers are assigned, use the DOI form of citation […]Hong-Tao Deng
- Photochromic covalent organic polymers (COPs) with dual response based on fast fluorescence and color transformation June 2, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00674D, Research ArticleLiyang Li, Fei Xin, Xuejing Wang, Yu ChenPhotochromic COP materials have attracted more and more attention due to their intelligent photophysical properties and specific responsive capabilities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Liyang Li
- Photoredox-Catalyzed Oxygen-Centered Radical-Mediated α-Alkoxycarbonyloxylation of Ketones June 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00472E, Research ArticleWenbin Shang, Xuan Zhang, Yali Yan, Jianlin Hu, Houxiong Zhang, Zhengshan Yang, Jinyu Yang, Han Xu, Yanju LongHerein, we report a visible‑light photoredox‑catalyzed α‑alkoxycarbonyloxylation of ketones using pyridinium‑derived alkoxycarbonyloxyl radicals (ACORs). Selective addition of photo‑generated ACORs to enol esters affords a broad range of α‑alkoxycarbonyloxylated products under...The […]Wenbin Shang
- Convergent paired photocatalyzed hydroarylation of β-alkenyl ketones with cyanoaromatics enabled by radical anion sorting June 1, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00426A, Research ArticleLu-Qian Wang, Ming Hu, Liang Zeng, Fu-Jin Sun, Jin-Heng LiRadical anion sorting-enabled regioselective convergent paired photocatalyzed hydroarylation of β-alkenyl ketones with cyano(hetero)aromatics, leading to β-aryl alkylketones, is depicted.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Lu-Qian Wang
- Visible-Light-Induced and Diastereoselective Synthesis of Fluorinated Tetrahydrofuran Derivatives June 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00585C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiangyu Tan, Carolina Gimbert Suriñach, Elies Molins, Roser Pleixats, Israel Fernandez, Adelina Vallribera, Albert GranadosThe stereocontrolled construction of molecules bearing three contiguous stereocenters is a formidable challenge in synthetic organic chemistry. We […]Xiangyu Tan
- Nickel-catalyzed switchable and regioselective iterative B–H arylation of carborane clusters June 1, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00507A, Research ArticlePing Li, Yanghua Wang, Jian Lu, Ju-You LuWe describe a nickel-catalysed switchable regioselective iterative B−H arylation of carboranes. This approach enables precise structural editing of carborane frameworks, readily affording diverse functionalized carborane derivatives.To cite this article before page numbers are assigned, use the DOI form of citation […]Ping Li
- Cobalt-catalyzed light-induced aminocarbonylative polymerization of aryl halides toward semi-aromatic polyamides June 1, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00386A, Research ArticleRongcai Wang, Nengbo Zhu, Hongli BaoLight-driven cobalt-catalyzed aminocarbonylative polymerization directly synthesizes semi-aromatic polyamides from aryl halides and aliphatic diamines under mild conditions, offering a sustainable route to diverse materials.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Rongcai Wang
- Distortion-Controlled Thermal Stability in Phenanthrene-Bridged Diarylethene Photoswitches June 1, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00505E, Research ArticleJiaxin Hou, Jinghao WangChiral dithienylethene (DTE) provide a distinctive platform for elucidating how subtle geometric and electronic perturbations govern photochromic switching behavior. Herein, we report four fused phenanthrene-based DTE with site-selective fluorine substitution....The content of this RSS Feed (c) The Royal Society of ChemistryJiaxin Hou
- Redox-Neutral electrochemical Diazo Coupling: Controlled Synthesis of Olefins and Azines via modulating reaction conditions June 5, 2026
