RSC – Org. Chem. Front. latest articles- Electrochemical 1,2-hydrogen atom transfer functionalizations of N-(benzyloxy)phthalimides October 4, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01607F, Research ArticleXin Fu, Tingting Ran, Jie LiuWe report a straightforward, catalyst-free method for the cathodic benzylic C–H hydroxyalkylation/arylation of N-(alkyloxy)phthalimides with ketones or cyanopyridines. The reaction is driven by an electrochemically induced 1,2-hydrogen atom transfer involving...The content of this RSS Feed (c) The Royal Society of ChemistryXin Fu
- Ir/XuPhos-Catalyzed Direct Asymmetric Reductive Amination of Ketones with Secondary Amines October 4, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01495B, Research ArticleZhou Luo, Tianxiang Fan, Jingyan Luo, Yuanyuan Liu, Junliang ZhangA diverse array of bidentate P-containing ligands has been developed for Ir-catalyzed asymmetric hydrogenation, but chiral monodentate phosphine ligands remained comperatively underexplored. We herein report a novel iridium catalyst with...The content of this RSS Feed (c) The Royal […]Zhou Luo
- Deoxygenative 1,3-Carbophosphination of Allylic Alcohols enabled by Manganese Pincer Catalyst October 2, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01652A, Research ArticleXin Chen, Guanbo Li, Hui Ma, Sheng-Yin Zhao, Weiping LiuOrganophosphines are versatile compounds with widespread applications in both organic synthesis and the development of biologically active molecules. Herein, we describe a manganese-catalyzed three-component deoxygenative 1,3-carbophosphination of allylic alcohols with...The content of this RSS Feed (c) The Royal […]Xin Chen
- Recent Developments in the Ring-Opening Transformations of gem-Difluorocyclopropanes October 2, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01583E, Review ArticleLeiyang Lv, Junqi Su, Zhiping Ligem-Difluorocyclopropanes (F2CPs), a unique class of cyclopropanes, have attracted particular interest of chemists due to their intrinsic reactivity. In this context, gem-F2CPs have been extensively studied as fluoroallylic synthons in...The content of this RSS Feed (c) The Royal Society of ChemistryLeiyang Lv
- Mechanistic Insights into the Gold(I)-Catalyzed [3,3]-Sigmatropic Rearrangement of Sulfoniums for the Formation of Chiral 1,4-Dicarbonyls or Formal α-Arylation of Carbonyl Compounds October 2, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01061B, Research ArticleWeiping Zhou, Ya-Qing HUANG, Vincent Gandon, Arnaud VoituriezStarting with vinyl sulfoxides and propargyl silane, the Au(I)-catalyzed asymmetric [3,3]-sigmatropic rearrangement of sulfonium intermediate furnished, after protodemetallation step and hydrolysis of thionium ion, the corresponding 4-oxo-2-aryl-2-alkyl-pentanal derivatives. From the...The content of this RSS Feed (c) The Royal Society of […]Weiping Zhou
- Exploring N-Centered Umpolung Reactivity in Photoredox-Catalyzed Amidation with α-Iminoester October 2, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01515K, Research ArticleParag Mistry, Subhankar Das, Rik Patra, Indranil ChatterjeeThe synthesis of amides and their derivatives has gained significant attention among the scientific community in recent decades due to the presence of amide moieties in many bioactive organic molecules....The content of this RSS Feed (c) The Royal Society of […]Parag Mistry
- Shining light on sulfonium salts and sulfur ylides: recent advances in alkylation under photoredox catalysis October 2, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01644K, Review ArticleZhe Jin, Tingwei Yu, Hui Wang, Penghao Jia, You HuangOrganosulfur compounds, especially sulfur ylides and sulfonium salts, offer extraordinary potential in organic chemistry due to their distinctive structural properties and reactivities. In the past five years, tremendous progress of...The content of this RSS Feed (c) The Royal […]Zhe Jin
- A supramolecular dimer strategy for enhancing the selective generation of sulfides and sulfoxides by visible-light induced photoredox thiol–ene cross-coupling reactions of anthraquinone October 2, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01454E, Research ArticleFa-Dong Wang, Kai-Kai Niu, Shengsheng Yu, Hui Liu, Ling-Bao XingA supramolecular dimer based on anthraquinone was constructed through host–guest interactions, which can not only improve the generation capacity of reactive oxygen species, but also be used as photocatalysts for photocatalytic C–S coupling reaction.To cite this article before […]Fa-Dong Wang
- Ion-pairing assemblies of anion-responsive helical PtII complexes October 1, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01697A, Research ArticleYohei Haketa, Maho Kawami, Wataru Ota, Tohru Sato, Hiromitsu MaedaNaphthylisoquinoline-appended dipyrrolyldiketone PtII complexes as helical π-electronic systems were synthesized. The PtII complexes, showing chiroptical properties in solution, exhibited anion-binding behaviour, resulting in the formation of anion complexes as pseudo...The content of this RSS Feed (c) The Royal […]Yohei Haketa
- Strongly fluorescent indolizine-based coumarin analogs October 1, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01216J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jaqueline S. A. Badaro, Antoni Wrzosek, Olaf Morawski, Adam Szewczyk, Irena Deperasińska, Daniel T. GrykoBlue to yellow-emitting 2-oxo-pyrano[2,3-b]indolizines, which are efficiently prepared in two steps from pyridinium salts, have strong emission across […]Jaqueline S. A. Badaro
- Asymmetric Synthesis of Pyrrolo[1,2-a]indoles via Bifunctional Tertiary Amine Catalyzed [3+2] Annulation of 2-Nitrovinylindoles with Azlactones September 30, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01557F, Research ArticleXiao-Long He, Xiaomei Li, Song Wu, Jiachen Xie, Jiang Deng, Junyuan Yan, Wei Li, Zhiming Li, Zhouyu Wang, Shan QianThe chiral pyrrolo[1,2-a]indole represents a privileged stuctural motif in many natual products and pharmaceutical agents. Herein we developed an efficient [3+2] annulation of 2-nitrovinylindoles with azlactones via the […]Xiao-Long He
- Hypervalent Iodide(III)-Mediated Thiofluorination of Alkenes and Alkynes from Thioureas/Thiocarbamoyl Fluorides with Water and Nucleophilic Fluoride Source September 30, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01569J, Research ArticleJunyi Zhou, Xiang Wang, Wenjun Tang, Liqin JiangHypervalent iodines(III) mediated oxo/aza/carbon/difluorination of alkenes have made significant progress although the corresponding fluorination of alkynes cannot been accomplished. However, hypervalent iodine(III) mediated thiofluorination of both alkenes and alkynes has...The content of this RSS Feed (c) The Royal Society of […]Junyi Zhou
- Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates September 30, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01502A, Research ArticleLongyu Xiao, Yifan Li, Jun Huang, Li Pan, Pan Wu, Yue WengThis paper aims to explore the applications of modified cysteine in biomedicine, addressing the challenges as-sociated with modifying amino acid residues (cysteine). It provides new avenues for the functionalization of...The content of this RSS Feed (c) […]Longyu Xiao
- A domino reaction strategy for facile and modular construction of synthetically challenging functionalized ortho-fluoroanilines September 29, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01692K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Benedikt Grau, Sascha W. Kohlbauer, Yungyeong Gu, Friedrich Hahn, Josephine Lösing, Christina Wangen, Maximilian Stangier, Lutz Ackermann, Manfred Marschall, Svetlana B. TsogoevaThe selective formation of ortho-fluoroanilines, representing versatile intermediates for the pharmaceutical […]Benedikt Grau
- A Chemoselective Radical Cascade Polarity-Mismatched Silylarylation of Unactivated Alkenes September 29, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01461H, Research ArticleLiang Liu, Xiao Yang, Jinghui Tong, Huajie Zhu, Lu Ouyang, Renshi Luo, Jianhua LiaoHere, we report an practical method to selectively access silylated pyrrolo[1,2-a]indole using alkenyl indoles and readily available silanes through a radical cascade cyclization. The reaction proceeds through an unusual intermolecular...The content of this RSS […]Liang Liu
- Non-Kolbe Oxidation Driven Electrochemical C(sp2)-H Lactonization towards the Synthesis of Isocoumarins September 29, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01381F, Research ArticleChen Liu, Hongpeng Liu, Gaoyuan Zhang, Yunge Liu, Pei Liao, Yongqun Mei, Yunfei ZhangA novel method for electrochemical C(sp2)-H lactonization was developed. This strategy enabled synthesis of various isocoumarins in moderate to excellent yields with good functional group tolerance. Gram-scale reaction and derivatizations...The content of this RSS […]Chen Liu
- Syntheses of highly functionalized cyclobutenes via [2+1+1] cycloaddition of isocyanides and an unprecedented ring expansion September 29, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01518E, Research ArticleXiang Han, Xing Ma, Jiulong Yu, Dong Xiong, Wei Du, Ya-Wen Wang, Yin Tian, Yangyang Cheng, Jianfeng ZhengA new type of Lewis acid catalytic [2+1+1] cycloaddition reactions of isocyanides with alkylidene malonates and 3‑alkylideneindolinones were reported herein. The method exhibited the easily accessible starting materials, broad substrate...The […]Xiang Han
- Asymmetric construction of spirobenzofuran indolinones via cascade reaction of 3-hydroxyoxindoles with coumarins September 29, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01471E, Research ArticleYanji Song, Yuqiao Zhou, Zheng Tan, Ziliang Jiao, Xiaoming Feng, Xiaohua LiuAn interesting asymmetric organocatalytic cascade reaction of 3-hydroxyoxindoles with coumarins was accomplished by chiral bisguanidinium hemisalt. A series of enantioenriched spirobenzofuran indolinones were afforded in high yields with high diastereo-...The content of this RSS Feed (c) […]Yanji Song
- BCl3 catalyzed Z-selective intramolecular chlorocarbamoylation of alkynes/allenes September 27, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01487A, Research ArticleZhantao Yang, Linlin Chen, Yuhang Zhao, Qianhui Chen, Wanjun Zhao, Linfei Li, Boxuan Zhang, Hua Xie, Xiangtao Kong, Chun-Hua YangA metal-free chlorocarbamoylation of alkynes/allenes catalyzed by BCl3 was described.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Zhantao Yang
- Transition-metal-catalyzed C–Ge coupling reactions September 26, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01637H, Review ArticleJie Ke, Cadmus Du Chen, Li-Qing Ren, Bing Zu, Bin Li, Chuan HeThis review covers the development and recent progress in transition-metal-catalyzed C–Ge coupling reactions. The goal is to provide a clear overview of the field, identify current challenges, and inspire further applications in this growing area.To […]Jie Ke
- Electrochemical 1,2-hydrogen atom transfer functionalizations of N-(benzyloxy)phthalimides October 4, 2024
