RSC – Org. Chem. Front. latest articles- Electrochemical Synthesis of Phosphorylated Glycine-Containing Oligopeptides July 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00803D, Research ArticleJian Wang, You Huang, Yirui Shen, Fulai Li, Yufen Zhao, Ju WuDABCO-mediated electrochemical synthesis of phosphorylated Glycine-containing oligopeptides has been developed, which eliminates the need for external oxidants. A series of di/tri/tetra/pentapeptides with different amino acid sequences were obtained in moderate...The content of this RSS Feed (c) […]Jian Wang
- DNA-Compatible Synthesis of Amidine Pharmacophores via Late-Stage Amine Modification July 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00818B, Research ArticleHuihong Wang, Jiale Huang, Xianfu Fang, Huilin Liao, Gong Zhang, Wei Fang, Yizhou LiAmidines are prevalent pharmacophores that are widely utilized in medicinal chemistry. The selective modification of amines within DNA-encoded libraries (DELs) offers a direct approach to constructing these pharmacophores, thereby enhancing...The content of this RSS […]Huihong Wang
- Outstanding Reviewers for Organic Chemistry Frontiers in 2024 July 2, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90049B, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Organic Chemistry Frontiers in 2024, as selected by the editorial team for their significant contribution to the journal.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]
- Photocatalytic Cleavage of Unactivated C(sp3)-H Bonds via Uranyl Cation: Enabling Allylation of Alkanes July 1, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00649J, Research ArticleYanxin Jiang, Songbai Tang, Yinying Luo, Zi-Xin Wang, Ze-Kai Li, Jing SuThe direct allylation of C-H bonds is a highly efficient and environmentally friendly method. Herein, a suc-cessful allylation of C(sp3)-H bond using uranyl cation as a highly efficient direct H...The content of this RSS Feed (c) […]Yanxin Jiang
- Copper-Catalyzed Stereo-Controllable Silylation of Allylic gem-Dichlorides July 1, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00690B, Research ArticleZi-Lu Wang, Pan-Pan Tian, Yun-He XuHerein, we present a ligand-regulated, stereo-controllable silylation reaction of allylic gem-dichlorides. In the absence of ligand, the reaction yields (Z)-vinyl chlorides with high stereoselectivity. Conversely, using a chiral Pybox ligand...The content of this RSS Feed (c) The Royal Society of ChemistryZi-Lu Wang
- Elucidating the mechanism and origin of stereoselectivity in C-C bond formation under isothiourea and amine cooperative catalysis July 1, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00726G, Research ArticleHui-Juan Liu, Yang WangCooperative catalysis integrating chiral amine and isothiourea organocatalysts offers a promising yet underexplored strategy for stereodivergent C–C bond formation. However, the interplay of their orthogonal activation modes and the origins...The content of this RSS Feed (c) The Royal Society of ChemistryHui-Juan Liu
- Selective deuteration of terminal olefins with D2O by catalysis of osmium-hydride complexes June 30, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00563A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wenwei Qin, Herman H. Y. Sung, Ian D. Williams, Guochen JiaAn catalytic system for selective deuteration of olefins was reported, which can deuterate terminal double bonds without isomerization and tolerate various functional […]Wenwei Qin
- Three-component copper-catalyzed difluoroalkylamidation of alkynes: An efficient approach to difluoroalkylated enamides June 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00751H, Research ArticleJing Ren, Kaiyun Liu, Jinlong Li, Xinyu Long, Kaizhi LiThis paper describes a selective three-component 1,2-difluoroalkylamidation of alkynes enabled by a coordinating activation strategy. This protocol utilizes commercially available difluoroalkyl halides as radical precursors and picolinamides as nitrogen sources,...The content of this RSS Feed (c) The Royal […]Jing Ren
- Photoredox catalytic γ‑C(sp3)−H vinylation of hydroxamic acid derivatives via 1,5-hydrogen-atom-transfer-mediated cross-dehydrogenative coupling June 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00747J, Research ArticleLingli Liu, Yangjian Cheng, Changduo Pan, Jin-Tao YuA visible-light-induced regioselective γ-C(sp3)-H vinylation of hydroxamic acid derivatives with 2-aryl enamides was developed via cross-dehydrogenative coupling (CDC) reactions for the first time. This remote γ-vinylation was realized by the...The content of this RSS Feed (c) The Royal Society of […]Lingli Liu
- Benzylic C–H bond functionalization through photo-mediated mesyloxy radical formation June 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00683J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jola Pospech, Jannik Thaens, Xinzhe Shi, Tobias Taeufer, Janina SchlappHerein, we report a photo-mediated methodology for the benzylic C‒H bond oxygenation. Our approach employs in-situ generated (methylsulfonyloxy)-pyridinium mesylate salts to produce mesyloxy […]Jola Pospech
- Synthesis and Properties of Quinoidal (Di-)Anionic Coupled Polymethine-Oxonol Dyes and Their Aromatic Counterparts June 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00801H, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Benjamin MOUROT, Carmelo Naim, Olivier Siri, Denis Jacquemin, Simon PascalWe report the synthesis of a new family of chromophores based on benzothiazole, indandione, and tricyanofuran moieties, forming aromatic neutral precursors or negatively […]Benjamin MOUROT
- One-pot C2-arylation and C4-acetoxylation of tryptophan derivatives via palladium-catalyzed tandem C–H activation June 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00671F, Research ArticleJia-Tian Liu, Jiashu Liu, Qi-Long Hu, Jian LiPalladium-catalyzed C2-arylation and C4-acetoxylation of indole within tryptophan derivatives was achieved in one pot by employing a TfNH–directing group.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Jia-Tian Liu
- Additive-Free Four-Component Radical Selenosulfonylation of Alkenes June 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00812C, Research ArticleMing-Qi Yang, Ying Tong, Jun-Qi Liu, Shi-Qing Zhang, Jia-Yao Feng, Hong-Lin Wu, Jin-Yang Chen, Jun-Qi Zhang, Hongxia Wang, Wenting WeiWhile multicomponent tandem reactions offer an efficient platform for the difunctionalization of alkenes, the precise regulation of component ordering in reaction systems remains a persistent challenge. Herein, we […]Ming-Qi Yang
- Synthesis of N-trifluoromethylsulfilimines via trifluoromethyl nitrene and their synthetic potential June 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00873E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Norbert Baris, Martin Dračínský, Luca Julianna Tóth, Blanka Klepetářová, Petr BeierPhotocatalytically generated triplet trifluoromethyl nitrene reacts with sulfides to afford new N-trifluoromethylsulfilimines.To cite this article before page numbers are assigned, use the […]Norbert Baris
- Correction: NaH-promoted one-pot oxidation/aromatization and C-3H chalcogenation of indoline: atmospheric control-based selective intermediates June 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90050F, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Suman Majee, Km. Anjali, Shaily Agarwal, Vishnu Poonia, Alok Kumar Singh, Biswajit Guchhait, Devalina RayTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Suman Majee
- Regioselective synthesis of C6-alkylated indoles utilizing electronic–steric effects enabled by imino exchange and phosphorus ylide addition June 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00344J, Research ArticleHaitian Zhu, Qiuqin He, Renhua Fan, Jiwen HeThis work reports the regioselective synthesis of C6-alkylated indoles from the dearomatized intermediates of 2-alkynylanilines utilizing electronic effects enabled by imino exchange with alkylamines and steric effects of phosphorus ylide addition.To cite this article before page numbers are assigned, use […]Haitian Zhu
- One-pot modular synthesis of 3-oxazolines from 2H-azirines, diazo compounds, and m-CPBA enabled by 2-azadiene–oxene (4 + 1) cycloaddition June 23, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00717H, Research ArticleIlya P. Filippov, Mikhail S. Novikov, Nikolai V. RostovskiiA formal (4 + 1) cycloaddition of oxene with a heterodiene was discovered and applied for the one-pot modular synthesis of 3-oxazolines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Ilya P. Filippov
- Bunte salt-mediated sulfonation of alkenes with sodium sulfinates June 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00618J, Research ArticleKemeng Zhang, Shuodan Ding, Jie Zhou, Xinyu Zhou, Ge Wu, XinLei WuBunte salts are frequently utilized as effective thiolation reagents for constructing thioethers.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Kemeng Zhang
- Au/Ag Synergistic Catalyzed Synthesis of 4H-imidazo-oxadiazin-4-ones via Three-Component Domino Cascade Cyclization June 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00540J, Research ArticleDongfang Jiang, Zhenjie Qi, Haifei Wang, Feng Liu, Can Yang, Xin Li, Hongchi ZhouA novel and efficient method for synthesizing a wide range of 4H-imidazo-oxadiazin-4-ones was achieved through a three-component domino cascade cyclization reaction of N-tosylhydrazones with α, β-unsaturated acids and amines, utilizing...The content of this RSS […]Dongfang Jiang
- Synthesis of 1,2-oxaborole via base-mediated borylation of propynols June 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00709G, Research ArticleSumit Ghosh, Sudip Laru, Mukta Singsardar, Alakananda HajraA one-step catalyst-free method has been reported for the efficient synthesis of valuable 1,2-oxaborole derivatives via borylation of propynols using only cesium carbonate as a base under mild reaction conditions.To cite this article before page numbers are assigned, use the […]Sumit Ghosh
- Electrochemical Synthesis of Phosphorylated Glycine-Containing Oligopeptides July 2, 2025
