RSC – Org. Chem. Front. latest articles- Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks April 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00197A, Research ArticleLeyla Saeifard, Kamran Amiri, Hormoz Khosravi, Felix Bauer, Frank - Rominger, Bernhard Breit, Thomas J.J. Müller, Saeed BalalaieA palladium-catalyzed domino sequence has been unlocked through the advent of a hitherto unreported class of ortho-X-allenyl tethered aryl isocyanides, highly reactive scaffolds that enable streamlined access to fused polycyclic...The […]Leyla Saeifard
- The lateral lithiation of pyrazoles: direct, transition-metal-free access to pyrazolopyridinones and pyrazolopyranones April 23, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00305B, Research ArticleKaijie Ji, Jason An, Kyle W. Rugg, Shayla G. Wood, Lakshi M. Thilakarathne, Krishna P. Gnyawali, Jesse D. Carrick, Jonathan T. ReevesLateral lithiation of amidopyrazoles enables an expedient, modular, transition metal-free synthesis of pharmaceutically relevant pyrazolopyridinones and pyrazolopyranones via reaction with nitriles or esters, respectively.To cite this […]Kaijie Ji
- Sacrifice of diorganyl diselenide Enables Cyclization of Aryl Propargyl Ethers in the Synthesis of 3-Organoselenyl Chromenones April 23, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00274A, Research ArticlePedro Pauletto, Yago C Bastianello, Davi Back, Cristina Nogueira, Gilson ZeniWe report the synthesis of 3-organoselenyl chromenones via a cascade cyclization of organoselenyl arylpropargyl ethers. The method is promoted by diorganyl diselenides and hydrogen peroxide. In this process, diorganyl diselenides...The content of this RSS Feed (c) The […]Pedro Pauletto
- A Metal-and Solvent-Free Bromination of Electron-Deficient Allyl and Benzyl C-H Bonds April 22, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00245E, Research ArticleQuanjin Rong, Qianhe Wang, Fan Wang, Zhong-Quan Liu, Xiaojing LiuBromination reactions of C(sp 3 )-H bonds at allylic and benzylic positions have been widely applied in the synthesis of pharmaceuticals and functional materials. However, traditional Wohl-Ziegler bromination reactions often...The content of this RSS Feed (c) The Royal […]Quanjin Rong
- Neocucurins A and B, two novel rearranged diterpenes from marine-derived fungus Neocucurbitaria unguis-hominis April 22, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00264A, Research ArticleHongxin Liu, Jinhua Hu, Yuchan Chen, Shanshan Wei, Haibo Tan, Weimin ZhangNeocucurins A (1) andB (2), were isolated from Neocucurbitaria unguis-hominis FS685. Neocucurin A was a diterpene with a unique 5/6/6/9 tetracyclic system, while neocucurins B featured the characteritic of bicyclo[8.3.1]tetradeca...The content of this RSS Feed (c) […]Hongxin Liu
- Contributors to the Organic Chemistry Frontiers Emerging Investigator Series 2025 April 22, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO90028C, ProfileThis profile showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator Series.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
- Design of 365 nm-Light-triggered Fluorogenic Crosslinking via a Genetically Encoded 3-CF3-p-phenylenediamine-Lysine Featuring Red-shifted Photo-defluorination April 22, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00284F, Research ArticleFan Zhang, Ziming Xiong, Siyu Kuang, Sitong Li, Xiaohu Zhao, Zhipeng YuWe introduce 3-CF3-p-phenylenediamine-L-lysine, a genetically encodable photo-Defluorination-Acyl Fluoride Exchange ncAA. It features red-shifted activation (311 → 365 nm) for faster photo-defluorination relative to 1st generation photo-DAFEx ncAA, and subsequent Ac-F...The content of this RSS Feed (c) […]Fan Zhang
- Post-Ugi synthesis of furo[2,3-c]isoquinolines with expanded π-conjugation display emission upon induced aggregation April 22, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00311G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tullio Crovetto, Lukas Biesen, Andrea Messina, Lisa Moni, Chiara Lambruschini, Bernhard Mayer, Thomas J. J. Müller, RENATA RIVAFuro[2,3-c]isoquinolines are tricyclic heteroaromatic structures that can be obtained by coupling the Ugi reaction with […]Tullio Crovetto
- A photoswitchable macrocyclic ion-pair receptor April 22, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00250A, Research ArticleKuirong Fu, Hui Liu, Xinyan Mai, Zhiyao Yang, Muyun Tao, Song Qin, Yimin Cai, Xiaowei Li, Wen Feng, Lihua YuanAchieving photoresponsive heteroditopic receptors capable of simultaneously binding and releasing ion-pairs under light irradiation remains a significant challenge, due to the difficulty in incorporating two distinct types of […]Kuirong Fu
- Ligand-controlled chemoselective nickel-catalyzed cross-electrophile coupling of cyclic anhydrides with alkyl bromides April 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00409A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tingzhi Lin, Junlong Jia, Yu Wu, Ziheng Li, Xueying Gao, Junyu Ma, Mengjiao Wei, Yifei Song, Zifan Wang, Xinrui Yuan, Patrick J. Walsh, Jianyou MaoThe introduction of chemoselective transition-metal-catalyzed cross-electrophile coupling approaches […]Tingzhi Lin
- Aerobic Synthesis of Zinc Organophosphate Complexes from Elemental Zinc: Enabling Phosphoric Acid Diester-Based Catalysis for O2-Mediated Baeyer-Villiger Oxidation April 20, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00244G, Research ArticleDaiki Mori, Motoya Nii, Shunta Nakamura, Fumitoshi Yagishita, Hitoshi Mizuguchi, Keiji Minagawa, Yukihiro ArakawaWe report the first aerobic synthesis of zinc organophosphate complexes, Zn[O2P(OR)2]2, from inexpensive elemental zinc (Zn(0)) and structurally diverse phosphoric acid diesters (PADs) under ambient conditions. This mild and operationally...The content of this RSS […]Daiki Mori
- Visible-light-induced acylation of active olefins by C-C bond cleavage/ Smiles rearrangement radical relay strategy via EDA complexes April 20, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00222F, Research ArticleLong-Jin Zhong, Shundan Li, Xiao-Han Ma, Pengfei Huang, Quan Zhou, Kewen Tang, Changhui Liu, Yu LiuPhotoinduced C-C bond activation of acyl oxime esters to generate aliphatic and aryl acyl radicals typically requires noble metal photocatalysts or synthetically elaborate organic dyes. In contrast, electron donor-acceptor (EDA)...The content of […]Long-Jin Zhong
- Crosslinked porphyrin–copper polymer catalyzed hydroboration of alkynes and alkenes April 20, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00365F, Research ArticleXin Liu, Shanben Yin, Xinxin Han, Jiaxi Cai, Qiaoya Wang, Le Liu, Xin-Hua Duan, Mingyou HuA recyclable porphyrin–copper porous polymer catalyst, COP-TPP-CuCl2, exhibits exceptional efficiency and selectivity in the hydroboration of alkynes and alkenes under mild conditions.To cite this article before page numbers are assigned, use the […]Xin Liu
- An Electrochemical Method for the Synthesis of Allyl Silanes. April 20, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00114A, Research ArticleTingting Feng, Lina Truong, Philippe Jubault, Thomas PoissonAllyl silanes are strategic building blocks in organic synthesis, used in the synthesis of important compounds including natural products, for instance. Their synthesis often requires the use of transition metal...The content of this RSS Feed (c) The Royal Society of […]Tingting Feng
- α-Borylcarbene precursors: design, generation, and synthetic opportunities April 19, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00368K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ryuya Miyazaki, Kei Muto, Junichiro Yamaguchiα-Boryl carbene precursors have evolved from classical diazo compounds to modern platforms including alkynes and haloalkanes. This review highlights diverse carbene-generation and design which control reactivity and […]Ryuya Miyazaki
- A 4-nitro-3-arylpyrrole Platform for the Divergent Synthesis of Marine Natural Products: Ningalins and Lamellarins April 19, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00105J, Research ArticleYihuan Yang, Guishun Bai, Jiajia Han , Mengyuan Wu, Yi Hua, Jian-Wei Chen, Jean Rodriguez, Damien Bonne, Hong Wang, Xiaoze BaoPyrrole is a key structural motif found in numerous bioactive molecules and natural products. Herein, we report an efficient and scalable synthesis of polysubstituted 3-arylpyrroles via a […]Yihuan Yang
- Metal-free, visible-light-driven multicomponent reactions of glycine derivatives with styrene and disulfide ether April 17, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00317F, Research ArticleDonghao Wang, Chenlu Zheng, Chao Shen, Min Wang, Jiabin ShenHerein, we report metal free, visible-light-driven multicomponent reactions of glycine derivatives with styrene and disulfide ether. This protocol features mild and green conditions, appreciable functional group tolerance, and broad substrate scope.To cite this article before page numbers are […]Donghao Wang
- Photochemical generation of P(V)–F bonds via BpyCu(CF3)3 in acidic media April 16, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00169F, Research ArticleChen Chen, Shuolu Dai, Min Luo, Tingting Li, Wen-Xin LvBpyCu(CF3)3 is repurposed as a novel fluorinating agent. Under photo/acid conditions, it fluorinates phosphinic acids and phosphine oxides efficiently. This work expands bpyCu(CF3)3's utility and offers practical access to phosphinic fluorides.To cite this article before page numbers are […]Chen Chen
- Synthesis and derivatization of N-amino amidrazones via coupling of aldehyde hydrazones with dialkyl azodicarboxylates April 16, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00187D, Research ArticleJinhai Xu, Qun Liu, Zhe Fan, Shuhan Sun, Zhichao Wang, Yongzi Yu, Jiashun Fang, Jin WangWe herein report a concise and convenient protocol for the synthesis of N-amino amidrazones via the coupling of aldehyde-derived hydrazones with dialkyl azodicarboxylates.To cite this article before page numbers are assigned, use […]Jinhai Xu
- Synthesis of functionalized hydrazonoyl chlorides through an unexpected Sc(OTf)3-catalyzed Friedel–Crafts reaction April 15, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00121A, Research ArticleLi-Yao Ding, Si-Qi Liu, Ying Luo, Chun-Hua Chen, Zhi-Xin Wang, Dong-Liang MoA variety of complex functionalized hydrazonoyl chlorides were prepared in good yields through a Sc(OTf)3-catalyzed Friedel–Crafts reaction of easily available arylhydrazonoyl chlorides with cyclobutanes under mild reaction conditions.To cite this article before page numbers are assigned, […]Li-Yao Ding
- Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks April 24, 2026
