RSC – Org. Chem. Front. latest articles- Recent advances in earth-abundant transition-metal-catalysed asymmetric oxidative sp³-sp³ cross-couplings Tháng 1 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01749A, Review ArticleJiao He, Perla Bharath Kumar, Yu-Long Li, Qiong Yu, Wei ShuAsymmetric sp³-sp³ cross-coupling reactions (including Csp³-Csp³, Csp³-Xsp3 and Xsp³-Xsp3 couplings) represent one of the most modular and straightforward methods to rapidly build saturation with control of stereochemistry by simply connecting...The content of this RSS Feed (c) The […]Jiao He
- Harnessing Alkaline-earth Metal Reactivity: Mechanistic Insights into Alkene and Alkyne Functionalization via Organomagnesium(II) and Organobarium(II) Catalysis Tháng 1 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01464F, Research ArticleYumiao MaMain-group catalysis is rapidly reshaping the landscape of modern catalysis, yet a detailed understanding of how s-block metals orchestrate complex bond transformations remains limited.Here, we present a comprehensive in silico...The content of this RSS Feed (c) The Royal Society of ChemistryYumiao Ma
- Divergent oxidative annulation of primary aliphatic amines to access semi-saturated fused pyrimidines or quinazolines Tháng 1 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01676B, Research ArticleKang Liu, Jiaoling Li, Fanqian Li, Xinyi Tang, Xue Peng, Yao-Fu Zeng, Xinping Liu, Guo-Jun Deng, Zhen Wang, Jinjin ChenA novel multicomponent reaction has been developed for the divergent synthesis of semi-saturated fused pyrimidines. Readily available cycloalkylamines, aldehydes and ammonium iodide were directly assembled through oxidative annulation […]Kang Liu
- Construction of the Tricyclic Core of Rhamnofolane-type Diterpenoids Tháng 1 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01699A, Research ArticleZhuang Wang, Zhaoyu Zhang, Xinyu Xie, Song Qin, Shaomin Fu, Bo LiuWe herein report the synthetic efforts toward the tricyclic core of rhamnofolane-type diterpenoids, featuring a 5-exo/ring-expansion/6-exo radical cascade sequence. Furthermore, direct stereoselective editing of a sterically hindered allylic C–H bond...The content of this RSS Feed (c) […]Zhuang Wang
- One-pot Dearomatizative C-Nucleophiles Telescoped Addition to Fluorinated 1,2,4-Oxadiazoles - Regioselective N-Functionalization Tháng 1 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01707F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Davide Castiglione, Sara Amata, Federica Lauria, Andrea Maranzana, Salvatore Baldino, Alexander Roller, Laura Castoldi, Antonio Palumbo Piccionello, Vittorio Pace, Eisuke Ignacio Comas IwasitaThe constitutive low aromaticity of easily accessible 5-trifluoromethyl-1,2,4-oxadiazoles is explored […]Davide Castiglione
- From acyl boronates to functional boronate-substituted and boron-containing heterocycles: emerging methods and applications Tháng 1 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01583A, HighlightKaja Gosak, Zdenko CasarOver the past decade, acyl boronates have emerged as versatile and valuable precursors in organic synthesis, facilitating the construction of diverse and important classes of compounds. In this review, we...The content of this RSS Feed (c) The Royal Society of ChemistryKaja Gosak
- Synthesis of quinazolinone scaffolds from the cascade reaction of o-aminobenzamides/o-aminobenzonitrile and calcium carbide mediated by K2S Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01490E, Research ArticleShuyi Li, Yunzhe Du, Ligang Yan, Siliu Cheng, Shuang Cao, Ruijun Xie, Limin Han, Ning ZhuAn efficient multicomponent methodology has been developed for the synthesis of quinazolinones and dihydroquinazolinones through the reaction of o-aminobenzamides or o-aminobenzonitriles with CaC₂ mediated by K₂S. The process begins with...The content of […]Shuyi Li
- Scandium-Catalyzed Asymmetric Addition of Allenylsilanes to β,γ-Unsaturated α-Ketoesters: Enantioselective Synthesis of Tertiary Homopropargylic Allylic Alcohols Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01584G, Research ArticleLinxuan Wang, Xiangqing Jia, Chen-Ho Tung, Zhenghu XuAn efficient scandium catalyzed regio-and enantioselective 1,2-homopropargylic addition of β,γ-unsaturated α-ketoesters with 1-substituted allenylsilanes has been developed. This protocol enables the synthesis of a broad range of enantioenriched tertiary homopropargylic...The content of this RSS Feed (c) The Royal Society of […]Linxuan Wang
- Pd(II)-Catalyzed Atroposelective C−H Olefination to Access [n]Naphthalenophanes Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01614B, Research ArticleXiaoyu Wang, Jia Li, Quan Tang, Changgui ZhaoA Pd-catalyzed late-stage C–H olefination of [n]naphthalenophanes has been developed. This method enables the synthesis of a series of enantiomerically enriched [n]naphthalenophanes with high chemoselectivity. The origin of atropisomerism was...The content of this RSS Feed (c) The Royal Society of […]Xiaoyu Wang
- Palladium-Catalyzed Four-Component Cascade Cyclization and Carbonylation of Bicyclobutyl (BCB) Amides Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01673H, Research ArticleJianwei Wang, Chunxue Pu, Jianfeng Xu, Yan Cao, Wei Chen, Jun YingA novel palladium-catalyzed four-component cascade cyclization and carbonylation of bicyclobutyl (BCB) amides has been developed for the rapid construction of functionalized spiroquinolinone scaffolds. The reaction of bicyclobutyl (BCB) amides with...The content of this RSS Feed (c) […]Jianwei Wang
- Asymmetric Michael-Mannich Cascade Reaction of Azomethine Ylides with Isatin-derived Trifluoromethyl Acrylates Catalyzed by a Cu(I) Catalyst Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01423A, Research ArticleXiaoying Cao, Pingde Tao, Saisai Yu, Shengwen Yang, Shi-Wu LiAn efficient, reliable and atom-economic strategy employing azomethine ylides with isatin-derived trifluoromethyl acrylates via michael-mannich cascade reaction to afford spirooxindole-pyrrolidine products featuring vicinal quaternary carbon centers at C3 and C4...The content of this RSS Feed (c) The Royal […]Xiaoying Cao
- Enantiodivergent Intermolecular Hydroamination of Acyclic 1,3-Dienes Using Aniline Nucleophiles Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01645B, Research ArticleTianlei Ren, Huan CongEnantioselective hydroamination of acyclic conjugated dienes represents a straightforward approach to the synthesis of chiral allylic amines. While recent advances have demonstrated remarkable regio- and enantioselectivity for a range of...The content of this RSS Feed (c) The Royal Society of ChemistryTianlei Ren
- Asymmetric Synthesis of 4,5-Dihydropyrrole Derivatives via DKR: DROC of Activated Aziridines with Enaminones Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01590A, Research ArticleAmit Kumar Sharma, Poulami Mandal, Ranjan Mali, Noimur Rahman, Nilay Kumar Pal, Manas K. GhoraiWe present a practical, efficient and highly enantioselective synthetic route to 4,5-dihydropyrrole derivatives via Dynamic Kinetic Resolution (DKR) assisted domino ring opening cyclization (DROC) of racemic aziridines with N,N-dimethyl enaminones...The content of this […]Amit Kumar Sharma
- Photocatalytic 3D Skeletal Editing of Carboxylic Acids via [4+1] Cyclization to Streamlined Synthesis of Unsaturated γ-Lactams Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01548K, Research ArticleJiahui Yu, Xiaohong Li, Liangbin HuangThe three-dimensional (3D) transformation of readily accessible planar molecules is of significant importance in drug synthesis. We herein report a photocatalytic strategy for the three-dimensional skeleton editing of carboxylic acids...The content of this RSS Feed (c) The Royal Society of ChemistryJiahui Yu
- Palladium(II)-Catalyzed Substrate-Controlled Diastereoselective Formal (3 + 3) Allylic Annulation of 2- or 3-Substituted 4-Hydroxy-but-2-en-1-yl acetates Tháng 1 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01637A, Research ArticleTuanli Yao, Nan Yang, Jun-E She, Xiangyang QinWe report a palladium(II)-catalyzed (3 + 3) allylic annulations between 2-(1-alkynyl)-2-alken-1-ones and 2- or 3-substituted (Z)-4-hydroxy-but-2-en-1-yl acetates. This substrate-controlled formation of constitutional isomers method efficiently delivers a diversity of 7-vinyl-6,7-dihydro-4H-furo[3,4-c]pyran...The content of this RSS Feed (c) The Royal Society of […]Tuanli Yao
- Dimethylamino-Iodine(III)/PPh3 -Mediated Synthesis of α-Ketoamides from Glyoxylic Acids Tháng 1 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01675D, Research ArticleYunfei Du, Dan Xiao, Jiaxin He, Kaiyue Yang, Zhijian Wang, Cong LiThe development of efficient synthetic approaches to α-ketoamides remains a significant objective. Herein, we report a mild and met-al-free method for the preparation of α-ketoamides from glyoxylic acids, mediated by...The content of this RSS Feed (c) […]Yunfei Du
- A Unified Strategy to access N-Heterocycles Enabled by Hypervalent Iodine(III) Reagent Mediated Imidate Radical Cyclization Tháng 1 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01301A, Research ArticleAkshay S. Pathare, Sermadurai SelvakumarWe report a unified strategy utilizing bench stable hypervalent iodine(III) reagent in the construction of phenanthridine, isoquinoline, quinoline and pyridine from aryl/alkenyl imidates. Mechanistic studies revealed the involvement of imidate...The content of this RSS Feed (c) The Royal Society of ChemistryAkshay S. Pathare
- Piezocatalyzed Cascade Cyclization of 1,7-Enynes with α-Keto Acids under Ball Milling Tháng 1 5, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01278C, Research ArticleYashuang Liu, Heng Li, Yan Liu, Bingxin YuanFused pyran motifs are key structural components in many bioactive compounds and pharmaceutical drugs. Traditional methods for synthesizing these heterocycles, such as Fe-catalyzed annulation and photocatalytic approaches, often face challenges...The content of this RSS Feed (c) The Royal Society of […]Yashuang Liu
- Syntheses of 1,2,3-functionalized naphthols and phenols by decarboxylative cycloaddition/aromatization reactions of a-oxygenated lactones with allenoates or electron-deficient alkynes. Tháng 1 3, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01582K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mohammad Sadeq Mousavi, Antonio Massa, Mario WaserBase-mediated reactions between hydroxy-pyrones or isochroman-3,4-diones and allenoates or butynoates allow for the direct synthesis of various 1,2,3-substituted phenols and naphthols under mild conditions. These transformations […]Mohammad Sadeq Mousavi
- EDA-complex photoactivation of thianthrene-based radical precursors enables divergent access to functionalized saturated heterocycles Tháng 1 2, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01397F, Research ArticleYingmin Ji, Roser Pleixats, Israel Fernández, Carolina Gimbert-Suriñach, Adelina Vallribera, Albert GranadosElectron-accepting thianthrenium and iminothianthrene species form EDA complexes with alkenoic substrates through π interactions, enabling a multibond-forming cascade that constructs diverse heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation […]Yingmin Ji
- Recent advances in earth-abundant transition-metal-catalysed asymmetric oxidative sp³-sp³ cross-couplings Tháng 1 10, 2026
