RSC – Org. Chem. Front. latest articles- Multistage Organic Redox Systems. Aromaticity as a Guiding Principle for Materials Chemistry Tháng 7 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00746A, Review ArticleMarcin Stępień, Ishfaq Ahmad Bhat, Ankit Kumar Gaur, Natasza SpruttaOrganic π-conjugated molecules capable of undergoing multistage redox processes have emerged as versatile platforms for applications in energy storage, molecular electronics, and optical devices. This review highlights the critical role...The content of this RSS Feed (c) The Royal […]Marcin Stępień
- Countercation– and solvent–controlled selective borohydride hydrogenation of alkenes in diaryl enones. Tháng 7 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00883B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Miguel Espinosa, Miquel Molina–García, Daniel Ciscares–Velázquez, Antonio Leyva-PerezBorohydrides are considered benchmark reagents for the selective hydrogenation of ketones in the presence of alkenes, a reaction described in organic textbooks. However, the opposite, […]Miguel Espinosa
- DFT Study of Nickel-Catalyzed Regio- and Enantioselective Hydroalkoxylation of 1,3-Dienes with Methanol: Inner-Sphere versus Outer-Sphere Mechanisms Tháng 7 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00814J, Research ArticleXia Zhao, Yong Xia, Xiaotai WangWe present a density functional theory (DFT) study on a remarkable nickel-catalyzed regio- and enantioselective hydroalkoxylation and C–O bond formation reaction of 1,3-dienes with methanol (a common yet underutilized oxygen...The content of this RSS Feed (c) The Royal Society of ChemistryXia Zhao
- Dynamic clipping strategy to synthesize [2]rotaxanes consisting of borate ion–containing crown ether and ammonium ions with kinetic and thermodynamic control Tháng 7 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00880H, Research ArticleTakumi Takizawa, Shinobu Miyagawa, Yuji TokunagaHerein, we report a dynamic clipping approach to synthesize (pseudo)[2]rotaxanes. A reversible borate-forming reaction between bis-catechol 1 and boric acid or trimethyl borate in the presence of secondary amines 2...The content of this RSS Feed (c) The Royal Society of ChemistryTakumi Takizawa
- Synthesis of 1,1-bis(indolyl)alkenes via nickel-catalyzed selective alkynylation of indoles with haloalkynes Tháng 7 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00787A, Research ArticleShuqi Guo, Xinni Qiu, Huanfeng Jiang, Shaorong Yang, Wanqing WuA novel nickel-catalyzed cascade alkynylation and nucleophilic addition of indoles with haloalkynes to synthesize 1,1-bis(indolyl)alkenes has been accomplished.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Shuqi Guo
- Triple C-F bond functionalization via an orderly elimination-oxidation-substitution relay Tháng 7 7, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00864F, Research ArticleXiongda Xie, Haoran Xu, Lixin Qian, Chen Gang, Yufei Zhang, Hui Miao, Kewei Chen, Xiao-Song Xue, Xinfang XuA primary challenge in defluorinative functionalization of readily accessible trifluoromethyl reagents is exhaustive-defluorination via repetition of the same reaction due to the strength of the bond decreases sequentially during defluorination....The […]Xiongda Xie
- A general rhodium-catalyzed regioselective C–H functionalization: accessing heteroarylated and alkenylated arenes Tháng 7 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00647C, Research ArticleTian Cao, Yan Wang, Shiping Zhan, Wenqian Ding, Xiaowei WuAn efficient rhodium-catalyzed C–H heteroarylation and alkenylation of pyridotriazoles and ortho-aryl heterocycles with iodonium ylides is reported. This strategy enables the synthesis of heteroarylated and alkenylated heterocycles and arenes.To cite this article before page numbers are assigned, use […]Tian Cao
- Lewis Acid Catalyzed Divergent Annulation of Bicyclo[1.1.0]butanes and Quinones for the Synthesis of Various Polycyclic Molecules Tháng 7 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00799B, Research ArticleRamji Meher, Subhas Chandra PanBicyclo[1.1.0]butanes have been harnessed in a divergent Lewis acid catalytic platform to access various polycyclic architectures. A variety of bicyclo[2.1.1]hexanes, spiro-cyclobutene-benzofuran-2(3H)-ones and tetrahydrocyclobuta[b]benzofurans were selectively accessed by tuning the reaction...The content of this RSS Feed (c) The Royal Society of ChemistryRamji Meher
- Suppressing hydrodechlorination in PC–Ni cocatalyzed C–N and C–O coupling reactions Tháng 7 6, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00660K, Research ArticleBo Yang, Hu Zhang, Yi-Ming Chen, Jian-Ping Qu, Yan-Biao KangIn this photocatalyst–Ni cocatalyzed C–N or C–O coupling reaction, the reaction system exhibits high selectivity and effectively suppresses the occurrence of dehalogenation side reactions.To cite this article before page numbers are assigned, use the DOI form of citation […]Bo Yang
- An Efficient Domino Protocol towards High Performance Organic Semiconductors: [1]Benzothiophene[3,2-b][1]benzothiophenes Tháng 7 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00766F, Research ArticleXinrui Cui, Jiahui Li, Yu Xiao, Kexin Xu, Wenyu Lai, Fengjiao Zhang, Baolin LiA highly efficient synthetic method toward [1]benzothiophene[3,2-b][1]benzothiophenes (BTBTs), high-performance organic semiconductors, through domino reaction has been developed. This protocol features inexpensive and readily available starting materials, catalyst-free, simple operation under...The content of this RSS […]Xinrui Cui
- Rapid construction of the [5–6–6] tricyclic core of sinudenoids B–D enabled by a tandem oxidation-intramolecular Diels–Alder reaction Tháng 7 3, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00722D, Research ArticleXiaofei Gao, Hui Shen, Yunxia Yang, Jia Li, Wei Chen, Gaoyuan Zhao, Huilin Li, Xingang Xie, Xuegong SheThe asymmetric synthesis of the [5–6–6] tricyclic core of sinudenoids B–D was accomplished via a tandem oxidation-intramolecular Diels–Alder reaction.To cite this article before page numbers are assigned, use the DOI […]Xiaofei Gao
- A new fully bridged spirophenylacridine derivative: synthesis and characterization Tháng 7 3, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00698H, Research ArticleShi-Jie Ge, Yue-Jian Yang, Rui-Hong Liu, You-Jun Yu, Rehman-Mehvish Abdul, Hai-Xiao Jiang, Wei Gao, Dong-Ying Zhou, Zuo-Quan JiangA new spirophenylacridine (SPA) derivative, SPA-SO2, was synthesized via full bridging of sulfone, carbonyl, and oxygen to the SPA core. For comparison, the characteristics of its precursor molecule SPA-S were […]Shi-Jie Ge
- Photocatalytic C–H functionalization of enamides with N-allylbromodifluoroacetamides via difluoroamidoalkylation and difluoroamidosulfonylation Tháng 7 3, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00764J, Research ArticleYu-Ting Wang, Xiao Zou, Peng-Cheng Xu, Dai-Xiang Chen, Yue Zhang, Sheng-Hu Yan, Hang-Dong ZuoThe photocatalyzed difluoroamidoalkylation and three-component difluoroamidosulfonylation have been established for the synthesis of trifunctionalized enamides with generally moderate yields along with outstanding regio- and stereoselectivity.To cite this article before page numbers are assigned, use […]Yu-Ting Wang
- DNA-compatible synthesis of amidine pharmacophores via late-stage amine modification Tháng 7 2, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00818B, Research ArticleHuihong Wang, Jiale Huang, Xianfu Fang, Huilin Liao, Gong Zhang, Wei Fang, Yizhou LiWe developed a hydroxylamine-mediated method for converting amino groups to amidines, enabling efficient coupling with diverse nitriles and broad protecting group tolerance, and applied it to the on-DNA synthesis of iNOS and PAD4 inhibitors.To […]Huihong Wang
- Outstanding Reviewers for Organic Chemistry Frontiers in 2024 Tháng 7 2, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90049B, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Organic Chemistry Frontiers in 2024, as selected by the editorial team for their significant contribution to the journal.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]
- Electrochemical Synthesis of Phosphorylated Glycine-Containing Oligopeptides Tháng 7 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00803D, Research ArticleJian Wang, You Huang, Yirui Shen, Fulai Li, Yufen Zhao, Ju WuDABCO-mediated electrochemical synthesis of phosphorylated Glycine-containing oligopeptides has been developed, which eliminates the need for external oxidants. A series of di/tri/tetra/pentapeptides with different amino acid sequences were obtained in moderate...The content of this RSS Feed (c) […]Jian Wang
- Copper-catalyzed stereo-controllable silylation of allylic gem-dichlorides Tháng 7 1, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00690B, Research ArticleZi-Lu Wang, Pan-Pan Tian, Yun-He XuA copper-catalyzed stereodivergent silylation of allylic gem-dichlorides was developed: ligand-free conditions gave (Z)-vinyl chlorides, while chiral Pybox ligands enabled access to enantiopure (E)-vinyl chlorides in high yield.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Zi-Lu Wang
- Photocatalytic cleavage of unactivated C(sp3)–H bonds via the uranyl cation: enabling the allylation of alkanes Tháng 7 1, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00649J, Research ArticleYan-Xin Jiang, Song-Bai Tang, Yin-Ying Luo, Zi-Xin Wang, Ze-Kai Li, Jing SuThe uranyl cation serves as a highly efficient direct hydrogen atom transfer (d-HAT) catalyst, enabling direct allylation of C(sp3)–H bonds with broad substrate compatibility, scalability, and potential for diverse functionalization.To cite this article before page numbers […]Yan-Xin Jiang
- Elucidating the mechanism and origin of stereoselectivity in C–C bond formation under isothiourea and amine cooperative catalysis Tháng 7 1, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00726G, Research ArticleHui-Juan Liu, Yang WangThe reaction mechanism and origin of stereoselectivity in the isothiourea and amine cooperatively catalyzed Michael addition reaction have been theoretically investigated using the DFT method.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Hui-Juan Liu
- Benzylic C–H bond functionalization through photo-mediated mesyloxy radical formation Tháng 6 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00683J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jola Pospech, Jannik Thaens, Xinzhe Shi, Tobias Taeufer, Janina SchlappHerein, we report a photo-mediated methodology for the benzylic C‒H bond oxygenation. Our approach employs in-situ generated (methylsulfonyloxy)-pyridinium mesylate salts to produce mesyloxy […]Jola Pospech
- Multistage Organic Redox Systems. Aromaticity as a Guiding Principle for Materials Chemistry Tháng 7 9, 2025
