RSC – Org. Chem. Front. latest articles
- Synthesis and anion recognition characteristics of a trapezoidal benzene cage Tháng Tư 23, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00699B, Research ArticleCaihong Mao, Ruiye Wu, Nana Chen, Hanliang Zheng, Yan Cai, Lichun Kong, Xiaobo HuThe molecular recognition pockets of functional biomacromolecules typically have complex spatial geometries. Creating low symmetrical cage molecules, which are different from traditional ones with highly symmetrical geometry, can increase the...The content of this RSS […]Caihong Mao
- Ring Expansion of Unsubstituted Aziridinium Ylide to Trifluoromethylated Dehydropiperidines Tháng Tư 23, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00537F, Research ArticleYongquan Ning, Jiaqi Tang, Tian Tian, Yingyu Wang, Dandan Wei, Yong Yang, Xin-Yu Wang, Paramasivam Sivaguru, Zhaohong Liu, Valentine NenajdenkoThe first rhodium-catalyzed [3+3] ring expansion of unsubstituted aziridines was achieved using trifluoroalkenyl N-triftosylhydrazones as vinylcarbene precursors to afford a serie of structurally diverse 2-trifluoromethylated dehydropiperidines under mild […]Yongquan Ning
- Catalytic Ortho C-H Methylation and Trideuteromethylation of Arylthianthrenium Salts via the Catellani Strategy Tháng Tư 21, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00506F, Research ArticleChen Chen, Xiao-Xu Zhang, Zi-Yi Wang, Chunjie Ni, Bolin ZhuWe reported a Pd/NBE cooperative catalyzed ortho C−H methylation and trideuteromethylation of arylthianthrenium salts, enabling the efficient synthesis of a wide variety of (trideutero)methylated arenes in moderate to good yields....The content of this RSS Feed (c) The Royal […]Chen Chen
- Halogen-Bond-Promoted Direct Cross-Coupling of Ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with Coumarins/Quinolinones Tháng Tư 21, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00484A, Research ArticleGuoliang Pu, Shi-Yuan Song, Jian Yang, Peng Guo, Jia Jia, Peijun Liu, Xuefei Li, Ping Liu, Chun-Yang HeHerein, we developed a practical method for the direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with coumarins/quinolinones, leveraging a halogen bond as the pivotal non-covalent interaction. Employing this protocol, a library of...The […]Guoliang Pu
- NHC-Catalyzed Stereoselective Synthesis of Spirooxindole Lactones by in situ Generated Oxindole-embedded o-Quinone Methides and Aldehydes Tháng Tư 21, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00347K, Research ArticleZhengqiang Cao, Fang Hu, Yunpeng Chu, Jiaxue Pei, Xin-Ping HuiA novel N-heterocyclic carbene-catalyzed asymmetric [4 + 2] annulation of in situ generated oxindole-embedded o-quinone methides with aldehydes has been developed for the assembly of complicated spirooxindoles. The methodology provides...The content of this RSS Feed (c) The Royal […]Zhengqiang Cao
- Regioselective Oxidative Cleavage of Conjugated Dienes to Access α,β–Unsaturated Nitriles Tháng Tư 18, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D3QO02101G, Research ArticleYuqing Fu, Yijia Leng, Haotong Bai, Jiaxi Xu, Ning ChenA highly regioselective oxidative cleavage method has been developed for the synthesis of α,β-unsaturated nitriles from unsymmetric conjugated dienes. This transformation selectively cleaved the terminal C=C double bond, providing moderate...The content of this RSS Feed (c) The Royal […]Yuqing Fu
- Iridium-catalyzed asymmetric hydrogenation of 5-hydroxypicolinate pyridinium salts under batch and flow: stereodefined access to cis-configurated hydroxypiperidine esters Tháng Tư 17, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00322E, Research ArticleZhi Yang, Shangxian Luan, Linxi Wan, Jingxi Chen, Xiaofang Wei, Pei Tang, Fen-Er ChenAn iridium-catalyzed asymmetric hydrogenation of 2-esteryl-5-hydroxypyridinium salts is reported, providing chiral cis-5-hydroxypiperidine-2-carboxylates in excellent yields with high levels of enantioselectivities and diastereoselectivities.To cite this article before page numbers are assigned, use the DOI form […]Zhi Yang
- Thiourea as a precatalyst for the electron donor–acceptor complex photoactivation platform of oxime esters Tháng Tư 17, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00424H, Research ArticleHaichen Mao, Yuting Zhang, Hengrong Cao, Qianqian Shi, Yu Lan, Junbiao Chang, Bo ZhuA novel electron donor–acceptor (EDA) complex catalysis strategy has been developed using thiourea as a precatalyst under blue LED irradiation. Using 2–5 mol% of thiourea, various nitrogen-containing compounds were successfully synthesized.To cite this article […]Haichen Mao
- Efficient Synthesis of Benzophosphole Oxides by Ag-Promoted Radical Cycloisomerization Tháng Tư 17, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00552J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liyao Ma, Sonia Mallet-Ladeira, Julien MONOT, Blanca Maria MARTIN VACA, Didier BourissouCycloisomerization reactions involving C–P bond formation have been overlooked to prepare P-heterocycles. We discovered here a simple, efficient and versatile route […]Liyao Ma
- Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives Tháng Tư 16, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00425F, Research ArticleShiyun He, Hongying Fan, Xue Zhang, Meiling Ye, Jian Chen, Jinyu Hou, Tianle Huang, Li Guo, Guanghui Lv, Yong WuA visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N-phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides […]Shiyun He
- Substituent-controlled divergent cyclization reactions of benzo[c][1,2]dithiol-3-ones and hexahydro-1,3,5-triazines Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00356J, Research ArticleBohao Zhang, Sifan He, Na Dong, Antong Zhu, Haojie Duan, Dunjia Wang, Yao ZhouAn unprecedented metal-free divergent cyclization reaction of benzo[c][1,2]dithiol-3-ones with hexahydro-1,3,5-triazines to assemble six- and eight-membered N-containing heterocycles has been developed.To cite this article before page numbers are assigned, use the DOI form of citation […]Bohao Zhang
- Selective nickel-catalyzed disulfuration of alkyl halides with di/trithiosulfonates Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00411F, Research ArticleLulu Liu, Jiaqi Hou, Yingying Ma, Hongwei Wang, Yu Zhong, Fangcan Liang, Luyao Wang, Qingling Wang, Ji-Quan Liu, Wen-Hua Xu, Dianhu ZhuSelective reductive disulfuration of alkyl halides with di/trithiosulfonate reagents was developed through ligand regulation, with key features of broad substrate scope, good tolerance and excellent selectivity […]Lulu Liu
- Expedient deaminative phosphorylation and sulfonylation of benzylic tertiary amines enabled by difluorocarbene Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00412D, Research ArticleChengbo Li, Yu Guo, Jianke Su, Xinyuan Hu, Qingqing Xuan, Qiuling SongA deaminative functionalization of aliphatic tertiary amines via the cleavage of C(sp3)–N bonds under transition metal-free conditions was disclosed, which goes through SN2 reaction with various phosphorus and sulfur nucleophiles.To cite this article before page numbers are assigned, […]Chengbo Li
- Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00481G, Research ArticleJia-Chen Xiang, Yu-Die Wang, Peng Yuan, Hui-Min Zhu, Tong Lei, An-Xin Wu, Zhixin LiaoThree typical substrates for the Mannich reaction, p-anisidine, aldehyde, and a nucleophile, did not afford the predictable linear Mannich base under an aerobic copper oxidation condition, but rendering a 2,2-disubstituted indolin-3-one product.To cite this […]Jia-Chen Xiang
- Cr-mediated photocatalytic decarboxylative coupling of alpha-oxo acids with benzylic pyridinium salts Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00475B, Research ArticleJia Cao, Yan Liu, Zhixiang Wang, Le LiuWe developed a method for chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium salts.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Jia Cao
- Palladium-catalyzed and ligand-controlled divergent cycloadditions of vinylidenecyclopropane-diesters with para-quinone methides enabled by zwitterionic π-propargyl palladium species Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00368C, Research ArticleJia-Hao Shen, Yong-Jie Long, Min Shi, Yin WeiA palladium-catalyzed and ligand-controlled divergent synthesis of spiro-cyclohexadienones from p-quinone methides and VDCP-diesters was realized via zwitterionic π-propargyl palladium species and the mechanism was clarified by DFT calculations.To cite this article before page numbers are assigned, use the DOI form […]Jia-Hao Shen
- Visible-light-induced [1,3]-brook rearrangements of α-ketoacylsilanes and their subsequent trapping in a tandem annulation with 1,3,5-triazinanes and azomethine imines Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00463A, Research ArticleZhong Zhang, Sirui Wu, Yuqiao Zhou, Bao-Lin Li, Siyue Xiao, Xiaohu Zhao, Zhipeng YuAn unusual visible-light-induced [1,3]-brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been realized to assemble various β-lactams and pyrazolidinone scaffolds.To cite this article before page numbers are assigned, […]Zhong Zhang
- Photochemical [2 + 2 + 1] annulation of 2-vinyloxy arylalkynes with bromomalonates via energy transfer Tháng Tư 15, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00249K, Research ArticleShuo Tang, Jiupeng Liu, Min Zhang, Dan Wang, Yong Wang, Jingjing Zhao, Pan LiA transition-metal-free, oxidant-free and base-free photochemical [2 + 2 + 1] radical annulation of 2-vinyloxy arylalkynes with bromomalonates has been developed.To cite this article before page numbers are assigned, use the DOI form of […]Shuo Tang
- Concise synthesis of succinimide-fused densely 1,3-cyclohexadienes via Co-catalyzed [2+2+2] cycloaddition of 1,6-diynes and maleimides Tháng Tư 15, 2024Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00435C, Research ArticleJinhui Cai, Kaili Cen, Ziyi Zhai, Yuan Liu, Jiahao Wei, Mixia Ouyang, Guojun He, Shuyu Huang, Feng ZhaoHerein, we report a new route towards succinimide-fused densely 1,3-cyclohexadienes through the reaction of 1,6-diynes with electron-deficient alkenes under cobalt catalysis. This method shown high efficiency, wide substrate scope, good...The […]Jinhui Cai
- Metal-free cascade O–H double insertion between I(III)/S(VI)-ylides, carboxylic acids, and alcohols: modular access to unsymmetrical α,α-O,O-substituted ketones Tháng Tư 14, 2024Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00453A, Research ArticleJiaohang Wei, Wen-Xuan Zou, Qiong Hu, Mei-Zhu Bao, Dan-Ting Shen, Lin Xiao, Jia-Lin Song, Xiang Liu, Shang-Shi ZhangHerein, we present a cascade O–H double insertion reaction between I(III)/S(VI)-ylides, carboxylic acids, and alcohols under metal-free conditions, enabling the modular synthesis of unsymmetrical α,α-O,O-substituted ketones.To cite this article before […]Jiaohang Wei
- Synthesis and anion recognition characteristics of a trapezoidal benzene cage Tháng Tư 23, 2024