RSC – Org. Chem. Front. latest articles- Photoinduced dearomative radical spirocyclization/oximation of nonactivated arenes: access to phosphorylated spirocyclic oximes with pH-responsive fluorescence and antitumor properties Tháng 5 18, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00552G, Research ArticleWei Ding, Qiming Xu, Miao-Miao Li, Huaixiang Yang, Huan MinDearomative radical ipso-spirocyclization has emerged as a powerful strategy for synthesis of valuable three-dimensional spirocyclic compounds from aromatic feedstocks, however the transformations are predominantly realized with activated arenes. Herein, a...The content of this RSS Feed (c) The Royal […]Wei Ding
- Rapid and Modular 1,2-Carboheterofunctionalization of Diverse Alkenes via Photoredox and RLT Catalysis Tháng 5 18, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00522E, Research ArticleSeok Beom Lee, Hyungwoo Choi, Junhwa Hong, Jinwoo Lee, Joonseok Jang, Sangmyung Han, Suckchang HongWe developed a mild photoredox- and iron-mediated radical ligand transfer (RLT) reaction system that enables the direct 1,2-carboheterofunctionalization of alkenes with a broad substrate scope. This transformation accommodates diverse radical...The content of this […]Seok Beom Lee
- Correction: Recent advances in catalytic asymmetric reactions of Morita–Baylis–Hillman adducts Tháng 5 17, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO90035F, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xu-Hong Duan, Hui-Ru Du, Yong-Xing SongTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryXu-Hong Duan
- Acridine/Lewis Acid Photocatalysis Enables α-Amidyl Radical Cyclizations Tháng 5 17, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00525J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Saurav Joshi, Dillon Rickertsen, Emma George, Ion Ghiviriga, Daniel SeidelA Lewis acid-activated acridine photocatalytic platform is reported that enables intramolecular Giese-type cyclizations of αamidyl radicals under mild photochemical conditions. This approach addresses […]Saurav Joshi
- Electrochemically Driven Nickel Catalysis for Formal C-H Amination Tháng 5 15, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00461J, Research ArticleGege Jiang, Yun Sa, Bingnan Wang, Duanyang KongThe C-H amination of arenes represents a streamlined approach to arylamines, yet most existing methods rely on preactivated nitrogen reagents or directing groups, limiting practicality and substrate generality. Herein, we...The content of this RSS Feed (c) The Royal Society of […]Gege Jiang
- Repurposing trichloroacetonitrile as a sustainable radical synthon for regiodivergent photocatalytic alkene amination Tháng 5 15, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00456C, Research ArticleXinlin Wang, Zhikai Li, Jia Jin, Kui Zhang, Lingchao CaiPersistent endeavors have been dedicated to the synthesis of nitrogen-containing compounds, which hold paramount significance in biological processes and are indispensable in the realms of pharmaceuticals and advanced materials. Herein,...The content of this RSS Feed (c) The Royal […]Xinlin Wang
- Catalyst-Controlled Chemodivergent C-H Functionalization of 2-Pyridylthiophenes with Allylic Alcohols Tháng 5 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00441E, Research ArticleGuibin Wan, Qiang Zhang, Ying Liu, Haowei Zeng, Taoyuan Liang, Shuangliang Zhao, Zhuan ZhangA catalyst-controlled chemodivergent C–H functionalization of 2-pyridylthiophenes using allylic alcohols as versatile coupling partners is reported. Modulation of the catalytic system enables selective access to two distinct reaction pathways from...The content of this RSS […]Guibin Wan
- Formal meta-Selective C–H Acylation of Pyridines via the Triplet State of Oxazinopyridine Intermediates Tháng 5 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00478D, Research ArticleFan Gao, Yajing Bian, Shiqing Huang, Xiaoyu YanPyridines are privileged structural motifs in pharmaceuticals and bioactive molecules. The introduction of substituents or functional groups at the meta-position via direct C–H functionalization of pyridines remains a formidable challenge....The content of this RSS Feed (c) The Royal Society of […]Fan Gao
- Aluminium-Catalysed Carbonyl-Selective Hydrophosphinylation of α,β-Unsaturated Ketones Tháng 5 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00397D, Research ArticleZiyuan Pang, Wen Dai, Xiaobo Yang, Xiaoli Ma, Hongping Zhu, Zhi YangAn aluminium-catalysed carbonyl-selective hydrophosphinylation of α,β-unsaturated ketones is reported herein. Among the synthesised Schiff-base-supported non-precious metal complexes, the aluminium hydride complex C1 exhibited outstanding catalytic activity. In contrast to conventional...The content of this RSS Feed (c) […]Ziyuan Pang
- A Streamlined Lithiation-Cyclization Strategy Unlocks Broad-Scope, Efficient Access to Chiral 3,4-Dihydroisoquinolones and Isoindolinones Tháng 5 14, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00462H, Research ArticleWenjun Luo, Hehua Lin, Ruinan Zhang, Genwei Zhang, Shaobin Tang, Daohong Yu, Zhengwang Chen, Zhong-Xia Wang, Junliang ZhangChiral 3,4-dihydroisoquinolones and isoindolinones serve as important chiral building blocks in pharmaceutical and natural product synthesis. Herein, we have developed a simplified and straightforward strategy that enables rapid and scalable...The […]Wenjun Luo
- A Generalized Electrochemical Dehydrogenation Approach en route to α-Phosphorylated Amines Tháng 5 13, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00588H, Research ArticleNayan Saha, Shana Chandran, Burkhard KönigGiven the widespread use of organophosphorus scaffolds in several disciplines, the formation of C(sp³)–P bonds is of fundamental importance. Direct access to α-phosphorylated amines still remains challenging, though, because conventional...The content of this RSS Feed (c) The Royal Society of ChemistryNayan Saha
- Photocatalytic Defluoroalkylation of Trifluoromethylaromatics with arylethylenes Tháng 5 13, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00541A, Research ArticleShiyong Guan, Yiteng Zheng, Zihan Cai, Yuegang ChenWe present a novel fluorine atom transfer technique for the selective functionalization of robust C-F bonds in trifluoromethylated aromatic compounds. This approach employs neutral boron radicals to generate aryl difluoromethyl...The content of this RSS Feed (c) The Royal Society of […]Shiyong Guan
- Modular Multicomponent Cascade Synthesis of Benzo[b]thiophene-Fused N,O-Heterocycles from 1,2-Benzisothiazoles, Benzolactones and Aldehydes Tháng 5 13, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00413J, Research ArticleLongzhi Lin, Jie Ren, Heying Chen, Shuang Liu, Chuanjun Song, Junbiao Chang, Yangang WuA modular, metal-free multicomponent cascade reaction for the synthesis of benzo [b]thiophene-fused seven-, or eightmembered N,O-heterocyclic compounds from 1,2-benzisothiazoles, benzolactones, and aldehydes has been developed. Notably, 1,2-benzisothiazoles were employed as...The content of this RSS […]Longzhi Lin
- A chiral multibrominated triangular macrocycle for modulating circularly polarized phosphorescence Tháng 5 13, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00378H, Research ArticleYuluo Huang, Jianqiu Li, Ming-Ze Meng, Tuo-Yu Zhou, Xiao-Nian Xue, Huang Wu, Shanshan Cheng, Yu WangThis work developed a chiral triangular macrocycle and achieved tunable circularly polarized room-temperature phosphorescence (CP-RTP) from blue-green to deep-red through rigidification and intermolecular charge-transfer interactions.To cite this article before page numbers are […]Yuluo Huang
- Intramolecular through-space heavy-atom effect in multiresonant thermally activated delayed fluorescence emitters with [2.2]paracyclophane Tháng 5 12, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00318D, Research ArticleYan Xu, Hassan Hafeez, Wenrui Wang, Ifor D. W. Samuel, Eli Zysman-ColmanThe heavy-atom effect (HAE) is a powerful strategy to enhance spin-orbit coupling (SOC) for accelerating reverse intersystem crossing (RISC) in multiresonant thermally activated delayed fluorescence (MR-TADF) emitters, which is relevant...The content of this RSS Feed (c) […]Yan Xu
- Conformational Features of N-Trifluoromethyl Amides and Thioamides Tháng 5 12, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00428H, Research ArticleRyu Yamasaki, Yuta Nozaka, Ami Nagai, Ai Ito, Masatoshi Kawahata, Iwao OkamotoWe investigated the structural and conformational features of N-trifluoromethyl (N-CF₃) (thio)amides using X ray and VT NMR analyses. These compounds showed lower rotational barriers and generally reduced cis populations compared...The content of this RSS Feed (c) […]Ryu Yamasaki
- Palladium-Catalyzed Synthesis of Aryl phosphonates Using Sodium Hypophosphite Tháng 5 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00520A, Research ArticleShang-Dong Yang, Dang-Wei Qian, Shi-Peng Chen, Hai-Chen MaAryl phosphonates represent a class of crucial structural motifs widely embedded in pharmaceutical molecular frameworks. Conventional synthetic approaches typically rely on PCl₃ or P(O)Cl₃ as the phosphorus source, which face...The content of this RSS Feed (c) The Royal Society of […]Shang-Dong Yang
- Imidazolium-dithiocarboxylate zwitterions catalyzed synthesis of fully substituted spiro-glutarimides via [3+3] annulation of cyclopropenones Tháng 5 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00157B, Research ArticleQichao Zhang, Fang Zhang, Qi Wu, Lin He, Zhihua Cai, Guangfen DuAn organocatalytic [3+3] annulation reaction of cyclopropenones and cyclic β-ketoamides has been reported for the synthesis of fully substituted spiro-glutarimides. Under the catalysis of imidazolium-dithiocarboxylate zwitterions (NHC•CS2), cyclopropenones react with...The content of this RSS Feed (c) […]Qichao Zhang
- Synergistic Interplay between Ligand and Metal-Centered Chirality in Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanols Tháng 5 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00471G, Research ArticleXueyuan Yan, Genping HuangDensity functional theory calculations were performed to investigate the Ir/CBL-catalyzed C(sp3)-H borylation of cyclopropanols. The computations indicate that the reaction follows an Ir(III)/Ir(V) catalytic cycle with six-and seven-coordinate intermediates, involving...The content of this RSS Feed (c) The Royal Society of ChemistryXueyuan Yan
- Recent advances in transition metal-catalyzed organic transformations using hemilabile P,P=O ligands Tháng 5 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00360E, Review ArticleZhenming Zhang, He Yang, Wenjun TangBisphosphine monoxides (BPMOs) represent a distinctive class of hemilabile bidentate ligands featuring a trivalent phosphine as a soft coordination site combined with a hard coordination site in the form of...The content of this RSS Feed (c) The Royal Society of ChemistryZhenming Zhang
- Photoinduced dearomative radical spirocyclization/oximation of nonactivated arenes: access to phosphorylated spirocyclic oximes with pH-responsive fluorescence and antitumor properties Tháng 5 18, 2026
