RSC – Org. Chem. Front. latest articles- A General Photocatalytic Strategy for Allylic C(sp3)–H Functionalization with Nucleophiles using Cyclohexyl Radical as a Hydrogen Atom Abstractor Tháng 6 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO00991J, Research ArticleQinhui Qinhui Chen, Yigao Tao, Rong HuThe selective transformation of hydrocarbons has become an exceedingly difficult challenge, especially in a stereo-selective manner. Despite remarkable progress, the simultaneous achievement of strong bond activation and versatile functionalization with...The content of this RSS Feed (c) The Royal Society of ChemistryQinhui Qinhui Chen
- Tandem catalytic Wittig reaction prepared isocoumarins: New family with tunable multi-stimuli-responsive fluorescence and bioactivity via halogen engineering Tháng 6 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00408C, Research ArticleMei Sun, Jie Zhou, Qiaoqiao Jia, Xiaogang Zhang, Wenya Song, Kai Chen, Cuie Shi, Jiaxin Hong, Chongyang Zeng, Mingwu DingTo address the limitations of current stimuli-responsive fluorophores in precision medicine and elucidate the role of halogen atoms, a novel family of isocoumarins (ICP-X) featuring both multi-stimuli-responsiveness and […]Mei Sun
- Long Visible-Light-Driven Bilin-Based Rotary Molecular Systems: from batch to microfluidics techniques Tháng 6 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00273K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lidia Hortigüela, Juan Antonio Garcia-Romero, Jose Justicia, Antonio J. Mota, Fátima Fernández-Álvarez, Ana M. Garcia, Araceli G. Campaña, Victor Blanco, Maria Victoria Gomez, Sara P. MorcilloExpanding the library of visible-light-driven rotary molecular […]Lidia Hortigüela
- Cobalt-Catalyzed Aerobic Intramolecular Hydroarylation of Allylic Alcohols via Hydrogen Atom Transfer and 1,2-Aryl Migration in HFIP Tháng 6 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00689B, Research ArticleXiao-Qing Xie, Chen-Jin Rao, Zi-Qiong Li, Chaozhihui Cheng, Lin Lu, Xian-Rong Song, Mu-Jia Luo, Qiang XiaoAryl migration represents a powerful strategy for the selective reconstruction of carbon-skeleton with high atom- and step-economy. Herein, an efficient cobalt-catalyzed 1,2-aryl migration for the intramolecular hydroarylation of allylic alcohols...The content of […]Xiao-Qing Xie
- Nickel-catalyzed annulation of strained cyclic allene and benzodicarboxylic anhydride Tháng 6 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00720A, Research ArticleGuo Yifeng, Zijun Zhou, Lei Cui, Peng Xu, Xinyao Li, Jian LiStrained cyclic allenes represent a class of in situ-generated transient intermediates with considerable ring strain and high chemical reactivity. These species are advantageous building blocks for the synthesis of complex...The content of this RSS Feed (c) […]Guo Yifeng
- Base-Mediated Double Defluorination and Bisthiolation of α-Trifluoromethyl Alkenes toward Monofluoroalkenes Tháng 6 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00557H, Research ArticleXin Guo, Hang Zhang, Long Xiao, Jiarui Liang, Guoliang Pu, Peng Guo, Jilin Wen, Jia Jia, Chun-Yang HeMonofluoroalkenes are valuable mimics of enol and amide bonds, making them pivotal in drug discovery. Here, we report a transition-metal-free defluorinative bisthioetherification of α-trifluoromethyl alkenes using thiols as the sulfur...The […]Xin Guo
- Dearomative 1,6-Difunctionalization of Styrenes via Photoredox Palladium Catalysis Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00706F, Research ArticleXin-Han Wang, Xin-He Han, Chun-Lin Zhang, Song YeAn efficient dearomative 1,6-difunctionalization of styrenes was developed via photoredox palladium catalysis, giving the corresponding alkylidenecyclohexadienes in moderate to good yields. Axially chiral alkylidenecyclohexadienes was obtained with promising enantioselectivity when...The content of this RSS Feed (c) The Royal Society of […]Xin-Han Wang
- Tryptophan-Selective Multicomponent Annulation for Direct Construction of Peptide-Embedded 2H-Chromenes Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00633G, Research ArticleCheng Ren, Lumeng Sun, Yicheng Lv, Xingxing Yang, Lin Yang, Chengxi LiDirect construction of heterocycles within peptide frameworks offers a concise strategy for expanding peptide chemical space, yet the development of chromene-forming annulation reactions compatible with peptides remains limited. Here we...The content of this RSS Feed (c) […]Cheng Ren
- Synthesis of Rigid-Flexible Chiral Borinic Acids and Application in Desymmetrization of Diols Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00673F, Research ArticleShan-SHan Xun, Gao-Wei Wang, Muwang Chen, Yong-Gui Zhou, Sheng-Mei LuDespite recent progress achieved in the development and application of chiral organoboron acid catalysts, the efficient chiral catalysts remain scarce due to the inferior stereocontrol arising from planar geometry of...The content of this RSS Feed (c) The Royal […]Shan-SHan Xun
- Synthesis of α-quaternary amino acid derivative via 1,2-rearrangement of ammonium ylide Tháng 6 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00155F, Research ArticleAo Huang, Rui Li, Zhenxiu Huang, Lei Wang, Xin Wang, Kaixin Du, Shi TangAlthough α-quaternary amino acids often exhibit notable bioactivity, their synthesis has received comparatively less attention, primarily due to the considerable steric hindrance posed by the quaternary center.To cite this article before page numbers are […]Ao Huang
- Unravelling the Assembly Pathways of Hydrogen-Bonded Amide-based [2]Rotaxanes: a Computational and Experimental Study Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00724D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel Hernandez-Hidalgo, Jose Manuel Garcia-Romera, Marta Marin-Luna, Alberto Martinez-Cuezva, Jose BernaThe assembly mechanism of hydrogen-bonded tetraamide-based [2]rotaxanes is studied through a combined computational and experimental approach. Two possible pathways, involving U-shaped and […]Daniel Hernandez-Hidalgo
- Photoelectrochemical hydroxymethylation and cyclization of N-aryl-2-CF3-acrylamides with TMSCH2OH Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00697C, Research ArticleLei Wang, Zhong-Wei Hou, Fei-Fei Xu, Quan ZhouAn organocatalyzed photoelectrochemical approach for the radical-mediated hydroxymethylation and cyclization of N-aryl-2-CF3-acrylamides with (trimethylsilyl)methanol (TMSCH2OH) has been developed. This reaction employs 2chloroanthraquinone (2-Cl-AQ) as the organocatalyst and TMSCH2OH as the...The content of this RSS Feed (c) The Royal Society of […]Lei Wang
- Enantioselective Cyanation-Brook Rearrangement-Protonation of Acylsilanes and Stereospecific Inversion in Brook Rearrangements Generating α-Nitrile Carbanion Equivalents Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00669H, Research ArticleMichiko Sasaki, Kei TakedaThe stereochemical course of Brook rearrangements that generate formal α-nitrile carbanion equivalents remains difficult to define because the resulting anionic species are intrinsically configurationally labile. Here we report two complementary...The content of this RSS Feed (c) The Royal Society of ChemistryMichiko Sasaki
- C-H functionalization reactions of heterocycles with alkyl halides via halogen atom transfer Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00654J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sudip Senapati, Anindya Das, Lilia Weizel, Daniel Merk, Ewgenij Proschak, Sandip Murarka, Rene M KoenigsDirect C-H alkylation of heterocycles is a fundamentally important strategy for the late-stage diversification of natural products and […]Sudip Senapati
- Enantioselective Diastereodivergent Reactions between Aldehydes and Bicyclo[1.1.0]butanes Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00662K, Research ArticleChengzhuo Wang, Shi Cheng, Zhidong Zhang, Liu Li, Ning Chen, Zhanhui Yang, Jiaxi XuDeveloping diastereodivergent and enantioselective catalytic reactions to access structurally and stereogenically diverse molecules from identical starting materials remains a central challenge in organic synthesis. Optically active three-dimensional saturated oxabicyclo[2.1.1]hexanes (oxaBCHs)...The content of this RSS […]Chengzhuo Wang
- N-Heterocyclic Carbene Catalyzed Enantioselective [5+1] Annulation to Access Indole-fused Spirocycles: A Remote δ-Carbon activation Tháng 6 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00374E, Research ArticleZhihang Li, Xiaoyong Duan, Dongyan Li, Keqing Liang, Qianqian Yang, Chang Guo, Zitong Yao, Chunfang Zhang, Jing QiHerein, we report the NHC-catalyzed enantioselective [5+1] annulation between indole-derived α,β,γ,δ-unsaturated aldehydes and 3-aminomaleimides. This methodology provides an efficient approach for constructing enantiomerically enriched indole-based spirocycles in good to excellent...The […]Zhihang Li
- Iron-Catalyzed Photoinduced Monohalogenation of α-Diazo Esters Using Halide Salt as Halogen Source Tháng 6 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00435K, Research ArticlePengjie Yao, Jingwen Yang, Yi Ma, Long Sun, Hongyan Zhao, Kangkui Li, Jingchao Chen, Baomin FanHalogenated compounds are valuable intermediates in organic synthesis, yet selective monohalogenation, especially chlorination, remains challenging under mild conditions. Herein, we report an iron-catalyzed, visible-light-induced ligand-to-metal charge transfer monochlorination and monobromination...The content of […]Pengjie Yao
- Visible-light-induced highly efficient catalysis of nitro reduction by Pd and FeCl₃ Tháng 6 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00601A, Research ArticleTianshu Qin, Lirong Yao, Hao Wu, Yihong Wang, Yue Chen, Dong Liu, aiqin liu, Zhushuang BaiSubstituted aromatic amines or heteroaromatic amines constitute a significant class of chemical intermediates. This paper reports a synergistic catalytic system comprising Pd/C and FeCl₃, which reduces nitro groups to amino...The content of […]Tianshu Qin
- A visible-light-induced, N-heterocyclic carbene-catalyzed four-component reaction of aroyl fluorides, diazo esters, cyclic ethers, and H2O Tháng 6 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00454G, Research ArticleJiayuan Shui, Yulong Niu, Hao Chen, Chuanying Li, Ze-Feng Xu, Lei WangHerein, we introduce a synergistic visible light and N-heterocyclic carbene (NHC) promoted four-component reaction of aroyl fluorides, diazo esters, cyclic ethers and H2O, providing an effective strategy for the construction...The content of this RSS Feed (c) […]Jiayuan Shui
- Switchable divergent reactions of α-aryl vinylsulfoniums with benzothiophene- and benzofuran-based aza-dienes Tháng 6 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00664G, Research ArticleJiao Yuan, Dong-Qun Huang, Lei Yang, Jian-Qiang Zhao, Yong You, Wei-Cheng Yuan, Zhen-Hua WangA switchable divergent reaction between α-aryl vinylsulfoniums and aza-dienes has been developed, enabling the one-pot synthesis of sulfur-containing 6–5–6- and 6–5–5-fused tricyclic compounds, as well as benzothiophene and benzofuran derivatives.To cite this article before […]Jiao Yuan
- A General Photocatalytic Strategy for Allylic C(sp3)–H Functionalization with Nucleophiles using Cyclohexyl Radical as a Hydrogen Atom Abstractor Tháng 6 26, 2026
