RSC – Org. Chem. Front. latest articles- Synthesis of Quinoline Derivatives by Palladium-Catalyzed Isocyanide Insertion/Undirected C(sp²)-H Functionalization/[4+1] Cyclization Reactions Involving Aryl Isocyanide Tháng 4 16, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00349K, Research ArticleShan-Shan Liu, Yong-Jie Wu, Jiang-Nan Zheng, Zhi-Lin Ren, Shao-Jie Jiang, Jun Wu, Ke-Ji Li, Ping He, Long WangThe study reports a novel palladium-catalyzed diaryl isocyanide insertion reaction strategy, which has opened up a brand-new avenue for the efficient synthesis of quinoline derivatives. The remarkable features of this...The […]Shan-Shan Liu
- Visible light-mediated halofunctionalization of alkenes for the synthesis of vicinally functionalized organohalides Tháng 4 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00439J, Review ArticleKanta Pajujantaro, Ying Chen, Gong-Qing LiuVicinally functionalized organohalides are employed in many reactions to prepare useful molecules. Among the various methods reported, halofunctionalization of alkenes has emerged as a powerful strategy for the preparation of...The content of this RSS Feed (c) The Royal Society of ChemistryKanta Pajujantaro
- Catalytic Rearrangement Reaction of p-Hydroxybenzyl Alcohols with o-Alkynylnaphthols for Synthesis of Naphthopyrans Tháng 4 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00225G, Research ArticlePing Wu, Chun-Dong Huang, Ye-Hui Ding, Yun-Xuan Chen, Jia-Hao Ji, Shaofei Ni, Yu Peng, Wei TanHerein, a Brønsted acid–catalyzed rearrangement reaction of p-hydroxybenzyl alcohols with o-alkynylnaphthols has been established, thus affording a series of structurally diverse naphthopyrans in moderate to good yields. This study represents...The content of […]Ping Wu
- Photocatalytic hydrogen atom transfer and aryl migration strategy for the arylalkylation of activated alkenes with 1-(o-iodoaryl)-alkan-1-ones Tháng 4 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00434A, Research ArticleYan-Lin Chu, Liang Zeng, Shuang Wu, Jie Yang, Ming Hu, Jin-Heng LiA visible-light promoted photocatalysis for remote C(sp3)–H alkylation of 1-(o-iodoaryl)alkan-1-ones with N-(arylsulfonyl)acrylamides via 1,5-hydrogen atom transfer (HAT), 1,4-aryl migration, and SO2-extrusion sequence to achieve various β-alkyl arylalkanones is described. The...The content of this RSS Feed (c) […]Yan-Lin Chu
- Organic photoredox catalyst induced divergent transformations of o-halogenated benzamides Tháng 4 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00407A, Research ArticleSa Li, Xuning Li, Jipan Yu, Xiao-Feng XiaThe development of powerful reducing organic photoredox catalysts has recently opened wide avenues to activate strong carbon-halide bonds. Herein, we demonstrate divergent transformations of aryl radicals through visible-light-induced carbon-halide bond...The content of this RSS Feed (c) The Royal Society of […]Sa Li
- Carboxylation of C(sp2)−H bonds in quinolone derivatives with CO2: Facile synthesis of quinolone carboxylic acids Tháng 4 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00491H, Research ArticleChangfu Li, Wei Zhang, Yunyi Xu, Yang Su, Tian-Yu Gao, Jian-Heng Ye, Lei Song, Da-Gang YuQuinolone carboxylic acids and derivatives are widely regarded as privileged scaffolds due to their broad-spectrum biological activities. Herein, we report a direct and efficient carboxylation of C(sp2)−H bonds in quinolone...The content of […]Changfu Li
- Palladium-catalyzed chemoselective decarboxylative coupling of alkynyl carboxylic acids with halogenated aryl triflates Tháng 4 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00339C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Miao Wang, On Ying Yuen, Shan Shan Ng, Chau Ming SoA palladium-catalyzed chemoselective decarboxylative coupling of alkynyl carboxylic acids with halogenated aryl triflates has been developed for the efficient synthesis of OTf-arylalkyne […]Miao Wang
- Continuous 1,4/1,6- and 1,2-addition reactions combined with the skeletal rearrangement of 5aH,13H-chromeno[2,3-b]quinolizin-13-ones with isocyanides to enable the synthesis of pyrido[2,3-b]indolizines Tháng 4 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00342C, Research ArticleSheng-Jiao Yan, Bi-Na Shao, Jia-Ming Yang, Li Chen, Wei-Min Zhang, Longkun ChenWe developed a protocol for the synthesis of highly functionalized pyrido[2,3-b]indolizines (PDIZs) 3 from 5aH,13H-chromeno[2,3-b]quinolizin-13-ones with ((isocyanomethyl)sulfonyl)benzene derivatives. The continuous cycloaddition of [1,4]/[1,6], and [1,2] and skeletal rearrangement were performed...The content of this RSS Feed (c) […]Sheng-Jiao Yan
- Controllable atom transfer enables photoredox-catalyzed defluorinative alkylation of trifluoromethyl alkenes with polychloroalkanes Tháng 4 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00369E, Research ArticleMu-Xiang Chen, Xin-Lu Fan, Zi-Yan Wang, Yi-Long Zhu, Xuefei Zhao, Zhenhua Jia, Xu-Hong HuPolychloroalkanes are commonly used solvents in organic synthesis, in which dichloromethane and chloroform have been intensively applied in radical-mediated alkene functionalization reactions. However, a general and mild protocol for selective...The content of this RSS […]Mu-Xiang Chen
- Advancements and Perspectives Toward Radical Truce−Smiles−type Rearrangement Tháng 4 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00360A, Review ArticleYuxi Wang, Xinyao Zhang, Kexin Kong, Chao ShuRadical Smiles rearrangement as a potent synthetic platform for arene functionalization efficiently facilitates the construction of (hetero)aromatic groups under gentle reaction conditions, and has proven to be a valuable tool...The content of this RSS Feed (c) The Royal Society of […]Yuxi Wang
- Monofluoromethylation of acyl chlorides and chloroformates employing fluorobis(phenylsulfonyl)methane. Synthesis of monofluoromethyl ketones via selective zinc-mediated reductive desulfonylation Tháng 4 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00451A, Research ArticleAlexander Knieb, Thomas Saal, Prabodh Rao, Xanath Ispizua-Rodriguez, G. K. Surya PrakashA high yielding protocol for the synthesis of valuable monofluoromethyl ketones (MFMK) utilizing fluorobis(phenylsulfonyl)methane (FBSM) is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Alexander Knieb
- Copper-catalyzed radical transnitrilation of arylborons with dimethylmalononitrile and mechanistic insights Tháng 4 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00397K, Research ArticleXiaofu Jian, Xibao Zhang, Weilong XieRadical transnitrilation of arylborons via a mild copper catalysis was developed, featuring broad scope, high functionality tolerance, scalability and practicality.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Xiaofu Jian
- Palladium-catalysed regio- and stereo-controlled C-2 β-fluorovinylation of indoles Tháng 4 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00521C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Atul K. Chaturvedi, Alastair J. J. LennoxVinyl-fluorides appended to heterocycles are a broadly underdeveloped family of functionality with potential application in bioactive compounds.To cite this article before page numbers are assigned, use […]Atul K. Chaturvedi
- Accessing chiral sulfones with an all-carbon quaternary stereocenter via photoinduced asymmetric Truce-Smiles rearrangement and radical sulfur dioxide insertion Tháng 4 10, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00383K, Research ArticleChenxin Wang, Wei Xiao, Jie WuChiral sulfones bearing an quaternary stereocenter are privileged structural units that are found in a variety of biologically active products and drug molecules. Herein, we present a photoinduced asymmetric Truce-Smiles...The content of this RSS Feed (c) The Royal Society of ChemistryChenxin Wang
- A metal-free, green strategy for intramolecular aminoalkoxylation of unfunctionalized olefins via catalysis using recyclable NIS, with water as the sole byproduct Tháng 4 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00535C, Research ArticleHui Sun, Liyuan Zhang, Xin Wu, Bin CuiA metal-free, green strategy for the intramolecular aminoalkoxylation of olefins using recyclable NIS as the catalyst achieves high yields (up to 96%) with water as the sole byproduct, offering a sustainable route to prolinol derivatives.To cite this article before page […]Hui Sun
- Direct Suzuki–Miyaura Cross-Coupling of C(sp2)–B(dan) Bonds Designed in Pursuit of Usability Tháng 4 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00230C, Research ArticleHiroki Andoh, Ryo Nakagawa, Tatsuya Akutagawa, Eiko Katata, Teruhisa TsuchimotoWe developed practical reaction conditions and procedure for the direct Suzuki–Miyaura cross-coupling (SMCC) of C(sp2)–B(dan) bonds. Below are important notes to successfully execute the direct SMCC: 1) Dehydrated conditions that...The content of this RSS Feed (c) The Royal […]Hiroki Andoh
- Enantioselective Catalytic Urech Hydantoin Synthesis Tháng 4 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00378D, Research ArticleWen-Ya Zheng, Zi-Qi Wang, Xing-Zi Li, Zhuo-Chen Li, Hua Wu, Abudu Rexit Abulikemu, Yu-Ping He5,5-Dicarbon-substituted hydantoins are the key skeletons of numerous drugs, but a general method for the enantioselective de novo synthesis of such scaffolds is elusive. On the other hand, Urech hydantoin...The content of this […]Wen-Ya Zheng
- Recent Advances in Repurposing Natural Enzymes for New-to-Nature Asymmetric Photobiotransformations Tháng 4 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00470E, Review ArticleFulu Liu, Xichao Peng, Jinhai Yu, Xiaoqiang HuangPhotobiocatalysis, which integrates the strengths of visible-light-catalysis and enzymatic catalysis, has established itself as a pivotal tool for asymmetric synthesis. Over the past decade, several naturally occurring enzymes have been...The content of this RSS Feed (c) The Royal Society of […]Fulu Liu
- Correction: Transition-metal-free borylation of propargylic alcohols: structurally variable synthesis in ionic liquid medium Tháng 4 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90027A, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sangepu Bhavanarushi, Yin Xu, Imran Khan, Zhibin Luo, Bin Liu, Jimin XieTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Sangepu Bhavanarushi
- [2.2]Paracyclophane-substituted quinolines by skeletal editing strategies Tháng 4 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00505A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tilman Köhler, Olaf Fuhr, Stefan BräseThe synthesis of 2- and 3-substituted [2.2]paracyclophanyl quinolines using two distinct skeletal editing strategies is described.To cite this article before page numbers are assigned, use the DOI […]Tilman Köhler
- Synthesis of Quinoline Derivatives by Palladium-Catalyzed Isocyanide Insertion/Undirected C(sp²)-H Functionalization/[4+1] Cyclization Reactions Involving Aryl Isocyanide Tháng 4 16, 2025
