RSC – Org. Biomol. Chem. latest articles
- Development of 18F-Labeled Azobenzothiazole Tracer for α-Synuclein Aggregates in the Brain April 30, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00492B, PaperJiajun Wu, Meiting Mao, Jie Yang, Kexin Li, Pengxin Deng, Jing Zhong, Xiaoai Wu, Yan ChengNuclear imaging of aggregated α-synuclein pathology is in urgent clinical need for Parkinson’s disease, yet promising tracers for brain α-synuclein aggregates are still rare. In this work, a class of...The content of this […]Jiajun Wu
- Structure and isomerization behavior relationships of new push–pull azo-pyrrole photoswitches April 29, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00417E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.David Gallardo-Rosas, José Manuel Guevara-Vela, Tomás Rocha-Rinza, Ruben Alfredo Toscano, Jose G. López-Cortés, M. Carmen Ortega-AlfaroA new family of stilbenyl-azopyrroles compounds 2a-d and 3a–d was efficiently obtained via a Mizoroki-Heck C-C-type coupling reaction […]David Gallardo-Rosas
- Visible-Light-Induced Three-Component Reactions of α-Diazoesters, Quinazolinones and Cyclic Ethers Selectively Lead to Quinazoline-Based Hybrids April 29, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00295D, PaperYiyuan Peng, Yan Liu, Qin Yang, Wei Wang, Yang Fu, Qiuping DingAn effective approach for the construction of 4-short-chain ether attached carbonyl group-substituted quinazolines was developed. The visible-light-induced three-component reactions of α-diazoesters, quinazolinones, and cyclic ethers, with broad substrate scope and...The content of this RSS Feed (c) The […]Yiyuan Peng
- Metal- and Photocatalyst-Free Approach to Visible-Light-Induced Acylation of Quinoxalinones. April 29, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00630E, PaperWorawat Niwetmarin, Naiyana Saesian, Rungroj Saruengkhanphasit, Chatchakorn Eurtivong, Nopporn Thasana, Somsak RuchirawatA transition-metal- and photocatalyst-free photochemical reaction was successfully developed for the direct acylation of quinoxalin-2(1H)-ones, which was enabled by the formation of electron donor-acceptor (EDA) complexes. The use of DBU...The content of this RSS Feed (c) The […]Worawat Niwetmarin
- Electrochemical Benzylic Deuteration of p-QMs Enabling the Synthesis of Benzylic Deuterated Diarylmethanes April 29, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00537F, CommunicationYunying Yan, Jianjun Hao, Yulin Peng, Mengyun Yin, Linhai Jing, Pan HanHerein, electroreductive umpolung benzylic deuteration of p-QMs using cheap and easily accessible D2O as a deuterium source was realized. Various value-added benzylic deuterated diarylmethanes can be synthesized without the requirement...The content of this RSS Feed (c) The […]Yunying Yan
- Supramolecular electrochemical probe based on the system of tetrazole derivative pillar[5]arene/methylene blue April 29, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00591K, PaperLaysan Makhmutova, Dmitriy Shurpik, Olga Mostovaya, Natalia Lachugina, Alexander Gerasimov, Adelya Guseinova, Gennady Evtugyn, Ivan StoikovFor the first time, an original synthetic approach has been developed that makes it possible to introduce ten tetrazole fragments into the pillar[5]arene structure. A supramolecular electrochemical probe was assembled...The content of this […]Laysan Makhmutova
- PIDA-Promoted metal-free [3 + 2] heteroannulation of β-ketothioamides with 4-hydroxy coumarins: chemo-/regioselective access to furo[3,2-c]chromen-4-ones at room temperature April 28, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00438H, PaperAnup Kumar Yadav, Dhananjay Yadav, Vipin Kumar, Subhasish Ray, Maya Shankar SinghHerein, we report a viable protocol to access furo[3,2-c]chromen-4-ones engaging easily accessible 4-hydroxy coumarins as a three-atom CCO unit and thioamides as a C2 coupling partner mediated by phenyliodine(III) diacetate...The content of this RSS Feed (c) The […]Anup Kumar Yadav
- BPO-Promoted [4 + 2] cyclization of enaminones and o-phenylenediamines to 2-acyl quinoxalines via a cascade transamination and C–H amination April 28, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00494A, CommunicationHeng Feng, Jie Hou, Xiaonan Mu, Renhua Zheng, Xiao Geng, Lei WangRapid assembly of quinoxalines in a single step from easily available precursors have been recognized as an ideal platform in term of efficiency and operation. Herein, we report a BPO-promoted...The content of this RSS Feed (c) The […]Heng Feng
- Photoinduced metal-free trifluoro/perfluoroalkylation of heteroarenes April 28, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00511B, CommunicationRavi Prakash Singh, Shashank SinghA practical and straightforward protocol to access trifluoromethylated/perfluoroalkylated heteroarenes via radical type nucleophilic substitution rather than typical radical type electrophilic substitution is described here. The substrate scope was observed to...The content of this RSS Feed (c) The Royal Society of ChemistryRavi Prakash Singh
- Development of an efficient and scalable bioprocess for the plant hormone 12-OPDA: Overcoming hurdles of nature´s biosynthesis April 28, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00258J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tim Guntelmann, Karl-Josef Dietz, Harald GrögerBesides its native biological function as plant hormone, cis-(+)-12-oxo-phytodienoic acid (12-OPDA) serves as a metabolite for the cellular formation of (-)-jasmonic acid and also turned out to have […]Tim Guntelmann
- Antimicrobial sesterterpenoids with a unique 5/8/6/5 tetracyclic carbon-ring-system and diepoxide polyketides from a deep sea-sediment-sourced fungus Chaetomium globosum SD-347 April 28, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00449C, PaperXiao-Dong Li, Xiao-Ming Li, Bin-Gui Wang, Xin LiTwo new sesterterpenoids, sesterchaetins A and B (1 and 2), and two new diepoxide polyketides, chaetoketoics A and B (3 and 4), were characterized from the culture extract of Chaetomium...The content of this RSS Feed (c) The Royal Society of ChemistryXiao-Dong Li
- Pd(II)/LA-catalyzed acetanilide olefination with dioxygen April 25, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00468J, PaperKaiwen Li, Shuangfeng Dong, Shuang-Long Li, Zhuqi Chen, Guochuan YinTransition-metal-catalyzed aromatic olefination through direct C-H activation represents an atom and step-economic route for versatile pharmaceutical syntheses, and in many cases, different stoichiometric oxidants were frequently employed for achieving a...The content of this RSS Feed (c) The Royal Society […]Kaiwen Li
- Efficient and Scalable Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones by Benzylic Oxidation of Tetrahydroisoquinoline Derivatives using Cerium Ammonium Nitrate (CAN) April 25, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00491D, PaperJiajun Luo, Zhilong Li, Jiaxin He, Tong Li, Daochen Wu, Yang Lai, Haiying SunHerein, we report an efficient method for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by oxidation of tetrahydroisoquinoline derivatives using cerium ammonium nitrate (CAN) and NaBrO3.The content of this RSS Feed (c) The Royal Society of ChemistryJiajun Luo
- Copper (II) nanodots stabilized on Cassia fistula galactomannan: preparation and catalytic application towards fast solvent-free Biginelli reaction April 25, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00441H, PaperBAL DEV SINGH, Jyoti Pandey, Huda Khanam, Bhoopendra Tiwari, Tazeen Azaz, Ayushi Mishra, Preeti KanchanNew Cu (II) nanodots have been developed by the use of biopolymeric polysaccharide galactomannan. The nanocatalyst Cu(II)NDs@CFG has been developed by one-step clean and sustainable reaction of Cassia fistula galactomannan...The content of this RSS […]BAL DEV SINGH
- Visible-light-induced C(sp3)-H bromination of 4-methylthiophene derivatives with HBr/H2O2 April 25, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00547C, PaperWenbo Song, Ming Ma, Wenjing Zhang, Cong-Cong Lu, Ranran Feng, Hong-Yu Zhang, Yuecheng Zhang, Jiquan ZhaoA convenient method to synthesize ethyl 4-(bromomethyl)thiophene-3-carboxylate derivatives has been developed via visible-light-induced radical processe with good yields and a wide range of functional group tolerance under air and ambient...The content of this […]Wenbo Song
- Polyketides with α-glucosidase inhibitory and neuroprotective activities from Aspergillus versicolor associated with Pedicularis sylvatica April 25, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00316K, PaperTingting Jiang, Liangliang Zhai, Zijue Wang, Xinyu Wang, Jian Nan Li, Yi Jie Zhai, Li Ding, Wen Bo HanAspergillus versicolor, an endophytic fungus associated with the herbal medicine Pedicularis sylvatica, produced four new polyketides, aspeversins A–D (1–2 and 5–6) and four known compounds, O-methylaverufin (2), aversin (3), varilactone...The […]Tingting Jiang
- Amino Acids as Bio-organocatalysts in Ring-Opening Copolymerization for Eco-Friendly Synthesis of Biobased Oligomers from Vegetable Oils April 25, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00339J, PaperFrancisca Werlinger, Monserrat Beroíza-Duhart, Oscar A. Douglas-Gallardo, Silvia Oyarzo-Aro, Maria Luisa Valenzuela, Oleksandra S. Trofymchuk, Mario E. Flores Flores, Javier MartinezHerein, we present an innovative synthetic approach for producing a diverse set of biobased oligomers. This method begins with olive oil and employs a wide variety of commercially […]Francisca Werlinger
- Microwave-Assisted Synthesis of Highly Sulfated Mannuronate Glycans as Potential Inhibitors against SARS-CoV-2 April 24, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00466C, PaperYirong Zhu, Xiaotong Wang, Siqian Lu, Jibin Zheng, Youling Liang, Liangliang Zhang, Pengfei Fang, Peng Xu, Biao Yu, You YangAlgae-based marine carbohydrate drugs are typically decorated with negative ion groups such as carboxylation and sulfation. However, precise synthesis of highly sulfated alginates is challenging, thus impeding their structure–activity […]Yirong Zhu
- Me3SiBr-promoted cascade electrophilic thiocyanation/cyclization of ortho-alkynylanilines to synthesize indole derivatives April 24, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00367E, CommunicationQing Wang, Chukai Shao, Ruirui Hua, Hongquan Yin, Fu-Xue ChenA Lewis acid-promoted electrophilic thiocyanation/cyclization of ortho-alkynylanilines for the synthesis of indole derivatives has been developed. The reaction utilizes Me3SiBr as the Lewis acid and N-thiocyanatosuccinimide as the thiocyanating reagent....The content of this RSS Feed (c) The Royal Society […]Qing Wang
- Synthesis of Acridones via Ir(III)-Catalyzed Amination Annulation of Oxazoles with Anthranils April 24, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00377B, CommunicationLin Dong, Han-Yi ZhouAn unprecedented Ir(III)-catalyzed C-H activation/amination/annulation of 2-phenyloxazoles with anthranils for the highly selective preparation of acridone derivatives in one-pot under controlled conditions is reported. This protocol is characterized by atom...The content of this RSS Feed (c) The Royal Society of ChemistryLin Dong
- Development of 18F-Labeled Azobenzothiazole Tracer for α-Synuclein Aggregates in the Brain April 30, 2024