RSC – Org. Biomol. Chem. latest articles- Synthesis of pyrano[3,2-c]chromene-2,5-diones from 4-hydroxycoumarins and aminocrotonates under solvent-free conditions December 19, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01800A, PaperShahnaz Begum, Sravani Kashameni, Sridhar Balasubramanian, Krishnaiah Atmakur, China Raju BhimapakaA one-pot new approach was developed for the construction of pyrano[3,2-c]chromene-2,5-diones by reacting 4-hydroxycoumarins with ethyl 3-oxo-3-phenylpropanoates in presence of ammonium salts or aminocrotonates under solvent-free conditions. Title compounds were...The content of this RSS Feed (c) The Royal […]Shahnaz Begum
- Photocatalytic E→Z isomerization of gem-bromofluoroalkenes: Stereospecific synthesis of β-fluorostyrene derivatives December 19, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01658K, CommunicationHayato Kato, Yoshihito Kayaki, Takashi KoikeStereoselective synthesis of β-fluorostyrene derivatives has been developed. Selective isomerization of gem-bromofluoroalkenyl benzenes bearing various ortho-substituent(s) is enabled by use of Ir photocatalysts with high triplet energy. Subsequent one-pot transition-metal...The content of this RSS Feed (c) The Royal Society of ChemistryHayato Kato
- Development of Urea-Bridged Cyclic Dominant Negative Pneumococcus Competence-Stimulating Peptide Analogs December 18, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01524J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mona Mehrani, Muralikrishna Lella, Katherine A. Graham, Nicholas B. Borotto, Yftah Tal-GanCyclization is a widely used approach to exert conformational restraint on linear peptide sequences. Herein, urea bridge chemistry was deployed to achieve […]Mona Mehrani
- ESIPT fluorescence turn-on sensors for detection of short chain inorganic polyphosphate in water December 18, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01926A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Subhra Roy, Sandra Moser, Tobias Dürr-Mayer, Rahel Hinkelmann, Henning Jacob JessenWe introduce two water-soluble excited state intramolecular proton transfer (ESIPT) based fluorescent turn-on probes responding to inorganic polyphosphates. These ESIPT probes enable specific […]Subhra Roy
- Aluminum-Catalyzed Anti-Markovnikov Hydroamination of Aromatic Alkenes with Aromatic Amines December 18, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01820F, PaperWenliang Yan, Xiaoli Ma, Qifeng Li, Ziyuan Pang, Xiaobo Yang, Yiwen Chen, Zhi YangHerein, we report a novel Al compound supported by a NacNac ligand that facilitates the anti-Markovnikov hydroamination of aromatic alkenes and primary amines. This represents the first instance of a...The content of this RSS Feed […]Wenliang Yan
- 1,4,5-Trisubstituted-1,2,3-Triazoles: An Unconventional Class of Ribonuclease A Inhibitors December 18, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01671H, PaperRashmita Pan, Swagata Dasgupta, Tanmaya Pathak1,4,5-Trisubstituted-1,2,3-triazoles (1,4,5-TTs) constitute a special class of functionalized triazoles. This paper reports the design of ribonuclease A (RNase A) inhibitors based on the 1,4,5-TT structural motif. The “catalytic triad” present...The content of this RSS Feed (c) The Royal Society of ChemistryRashmita Pan
- Recent advances in the reaction of isatin-derived MBH carbonates, synthesis of spiro-oxindoles December 18, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01299B, Review ArticleKaiwen Zhao, Minghao Zhai, Lei Zhang, Xiangtai MengAs one of the main fragments in medical drugs, spirooxindole has received considerable attention from organic and medicinal chemists. In the past few decades, chemists have been searching for more...The content of this RSS Feed (c) The Royal Society of […]Kaiwen Zhao
- Copper/Iron Controlled Regioselective 1,2-Carboazidation of 1,3-Dienes with Acetonitrile and Azidotrimethylsilane December 18, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01661K, PaperJun-Wei Hu, Yao Zhong, Ren-Jie SongThe azidocyanation and diazidation were carried out on 1,3-dienes compounds, using TMSN3 as the azide source and MeCN as the cyanoalkylation reagent. This method exhibits excellent functional group tolerance, a...The content of this RSS Feed (c) The Royal Society of ChemistryJun-Wei Hu
- Photoinduced SF6 degradation for deoxyfluorination of propargyl alcohols December 17, 2024Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01839G, CommunicationYue Zhao, Fengxiang Ma, Yifeng Chen, Shiyu Gu, Feng Zhu, Jun Cao, Shan Zhu, Lan-Gui XieDeoxyfluorination of propargyl alcohols has been developed using greenhouse gas sulfur hexafluoride (SF6) as the fluorinating reagent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Yue Zhao
- Palladium–Catalyzed α-Arylation of Sulfoxonium Ylides with Aryl Fluorosulfates December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01694G, PaperQing-Dong Wang, Jing-Ao Ren, Xu-Rong Cao , Xiaocong Zhou, Jin-Ming Yang, Zhi-Liang ShenA variety of α-arylated sulfoxonium ylides could be facilely synthesized in modest to high yields through an α-arylation of sulfoxonium ylides with aryl fluorosulfates via C-O bond cleavage under palladium...The content of this RSS Feed (c) […]Qing-Dong Wang
- Organo-photocatalytic dearomative hydrosilylation of indoles with silanes December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01792G, PaperQiao Zhang, Yadi Xu, Congjian Xia, Wengang Xu, Mingbo WuA photocatalytic dearomative hydrosilylation reaction of indole derivatives with silanes has been accomplished for the synthesis of valuable indolinyl silanes through a carbon-silyl radical coupling process with the cooperation of...The content of this RSS Feed (c) The Royal Society […]Qiao Zhang
- TFA-catalyzed solvent-free dearomative cyanidation of isoquinoline using (Boc)₂O as acylation agent December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01849D, PaperXujin Zhang, Li-Hua Huang, Ye Zhang, Fanhua Meng, Xiandong Dai, Chunru Cheng, Yongbiao Guo, Zhenhua GaoA TFA-catalyzed dearomative cyanidation of isoquinoline is described, which provides a series 1-cyanoisoquinoline in high yields under solvent-free conditions. This protocol is operated under mild and environmentally friendly conditions, utilizing...The content of this […]Xujin Zhang
- A novel bis-phosphonyl C-glycoside: the first synthesis of C-(1,6-deoxy-β-D-glucopyranosyl)dimethylphosphonate, a stable bisphosphonate to probe the mechanism of β-phosphoglucomutase December 17, 2024Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01756K, PaperRamprasad Ghosh, David L. Jakemanβ-Phosphoglucomutase (β-PGM) catalyzes the interconversion of β-D-glucose-1-phosphate and β-D-glucose-6-phosphate sequentially utilizing a transient aspartyl-phospho enzyme and a β-D-glucose-1,6-bisphosphate intermediate.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Ramprasad Ghosh
- Catalyst-Free Coupling of Peroxypyrroloindolenines with Amines to Afford Stable Peroxyindolenines December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01736F, PaperXiaoshan Zheng, Menghan Wang, xianbin sun, Yu Gao, Haijun ChenHere we report a highly efficient method for coupling of peroxypyrroloindolenines with amines under catalyst-free conditions to obtain stable C2-N peroxyindolenines in high yields with remarkable functional group tolerance. Initial...The content of this RSS Feed (c) The Royal Society […]Xiaoshan Zheng
- Biobased ionic liquid from natural α-hydroxy acid as halide-free organocatalyst for cycloaddition of CO2 to epoxid December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01646G, PaperNing Li, Min Zhang, Zhenjiang Li, Yongzhu Hu, Na Shi, Yujia Wang, Yanqi Shi, Xin Yuan, Ziqi Liu, Kai GuoThe cycloaddition of CO2 to epoxides (CCE) reactions produced valuable cyclic carbonates useful in electrolytes of lithium-ion batteries, as organic solvents, and in polymeric materials. However, halide-containing catalysts were […]Ning Li
- The selenium-assisted copper-catalyzed synthesis of phosphoramide from secondary phosphine oxide involves the construction of N-P bonds December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01860E, CommunicationZhenzhen Wang, Li-Hua Huang, Rui Huang, Juan Wang, Chunru ChengIn this study, phosphoramide compounds were successfully synthesized via a series of reaction transformations from P(O)H compounds. The process began with the formation of P-Se-Ar bonds, facilitated by the synergistic...The content of this RSS Feed (c) The Royal Society […]Zhenzhen Wang
- 6H-Indolo-[2,3-b]-Quinoxaline derivatives as promising bifunctional SHP1 inhibitors December 17, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01492H, PaperChun Zhang, Yi-Xin Dong, Lixin Gao, Suya Gan, Wenran Gao, Jia Li, Da-Jun Xiang, Xin Wang, Yu-Bo Zhou, Wenlong WangThe dysfunction in the SHP1 can cause cancers and many diseases, so it is of great significance to develop novel small molecule SHP1 inhibitors. Through continuous monitoring of metabolic […]Chun Zhang
- Conservation of structure and dynamic behavior in triazine macrocycles with opportunities for subtle control of hinge motion December 16, 2024Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01751J, PaperCasey Patterson-Gardner, Hongjun Pan, Benjamin G. Janesko, Eric E. SimanekWhile sharing a common, hinge-like motion, steric congestion created by isopropyl groups reduces the barrier to hinging by ∼1.5 kcal mol−1 over macrocycles with less cumbersome substitutions.To cite this article before page numbers are assigned, use the DOI form […]Casey Patterson-Gardner
- Submicromolar Fluorescence ‘Turn-on’ Detection of Fluoride Anion Using meso-(tetra-Aryl) Calix[4]pyrrole December 16, 2024Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01708K, PaperAnik Roy, Ranjan Dutta, Dibakar Halder, Koushik Mandal, Somenath Kundu, Maidul Hossain, Indrajit Saha, Chang-Hee LeeMeso-tetra-aryl picket calix[4]pyrrole 1 featuring p-fluorophenyl groups at all four meso-positions in cis-configuration has been synthesized and characterized unambiguously using single crystal X-ray diffraction analysis. This pre-organized system possesses a...The content of this […]Anik Roy
- Glyoxylic acid monohydrate promoted reductive addition of sodium sulfinates to pillar[4]arene[1]quinone December 16, 2024Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01908C, PaperEnfu Zhang, Da Ma, Chenghao ZhuSulfonate esters are introduced to pillar[4]arene[1]quinone through reductive addition of sodium sulfinates (15 examples with high selectivity).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryEnfu Zhang
- Synthesis of pyrano[3,2-c]chromene-2,5-diones from 4-hydroxycoumarins and aminocrotonates under solvent-free conditions December 19, 2024
