RSC – Org. Biomol. Chem. latest articles
- Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines April 22, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00348A, PaperYong-Xiang Lü, Xinqian Wang, Ying-Ming Pan, Keyume AblajanA method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant....The content of this RSS Feed (c) The Royal Society of ChemistryYong-Xiang Lü
- K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles April 22, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00488D, PaperMeng-Yang Chang, Chin-Huey Ho, Hsing-Yin ChenThe K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....The content of this RSS Feed (c) The Royal Society of ChemistryMeng-Yang Chang
- A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence April 21, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00610K, CommunicationChandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali NairWe hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...The content of this RSS Feed (c) The Royal Society of […]Chandra Volla
- Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction April 21, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00490F, CommunicationSIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh DasAn efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...The content of this RSS Feed (c) The Royal Society of ChemistrySIDDHARTHA KUMAR SENAPATI
- New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines April 21, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00291A, PaperMichael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai KuznetsovThe implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current […]Michael S. Alexeev
- N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives April 21, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00243A, PaperGyörgy Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin KaraghiosoffBeta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...The content […]György Keglevich
- Isothiocyanates: Happy-Go-Lucky Reagents in Organic Synthesis April 18, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00281D, Review ArticleBubul Das, Anjali Dahiya, Bhisma K Patel: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic...The content of this RSS Feed (c) The Royal Society of ChemistryBubul Das
- Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS) April 18, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00328D, CommunicationXuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei DuThe combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...The content of this RSS Feed (c) The […]Xuemin Li
- Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery April 18, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00236A, Review ArticleGoverdhan Mehta, Saumitra Sengupta, Srihari PabbarajaOften referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...The content of this RSS Feed (c) The Royal Society of ChemistryGoverdhan Mehta
- Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports April 17, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00272E, PaperBrenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah CaldasThis study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural […]Brenno A. D. Neto
- Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles April 17, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00432A, PaperPeng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...The content of this RSS Feed […]Peng-Fei Huang
- Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes April 17, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00167B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. SmirnovaEPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.To cite this article before […]Maxim A. Voinov
- Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism April 17, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00397G, PaperAngel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. MöllerHerein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...The content of this RSS Feed (c) […]Angel H Romero
- Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones April 17, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh NguyenA cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.To cite this article before page numbers are assigned, […]Cao Nguyen Nguyen
- Exploring the mechanism of the reductive amination of acetophenones via Borch approach: the role of the acid catalyst April 16, 2024Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00160E, PaperJoão Pedro Albuquerque Souza, Amanda Krauskopf Jacobs, Leandro Piovan, Renan Borsoi CamposThe energetic viability of several mechanistic variations of the reductive amination of acetophenones via the Borch approach was reexamined through density functional theory calculations. The crucial involvement of the acid...The content of this RSS Feed (c) The […]João Pedro Albuquerque Souza
- Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction April 16, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00363B, PaperSi-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong XieA three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Si-Yu Wang
- Recent developments in the enzymatic modifications of steroid scaffolds April 15, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00327F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Huibin Wang, Ikuro AbeThis review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.To cite this article before page […]Huibin Wang
- Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes April 15, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00297K, PaperWei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi SongAcceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.To […]Wei Luo
- Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis April 15, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00171K, Review ArticleBor-Cherng Hong, Ranadheer Reddy IndurmuddamThis review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryBor-Cherng Hong
- Catalyst- and base-free visible light-enabled radical relay trihalomethylation/functional group-migration/carbonylation with CX3SO2Cl April 15, 2024Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00292J, PaperJinkai Hu, Chenglei Yang, Xiaotao Qin, Hui Liu, Tongtong Ma, Ao-tong Shi, Qing-Long Lv, Xingman Liu, Jinhui Yang, Dianjun LiA visible light-enabled photocatalyst-free radical trihalomethylation/cyano (or benzo[d]thiazol-2-yl) 1,4-migration/carbonylation reaction of 2-hydroxy-2-hex-5-enenitrile (or (benzo[d]thiazol-2-yl)-pent-4-enol) with CX3SO2Cl (X = F, Cl) is reported.To cite this article before page numbers are […]Jinkai Hu
- Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines April 22, 2024