RSC – Org. Biomol. Chem. latest articles- Recent advances in allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis May 17, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00343E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Etikala Ashok, Junghwa Woo, Juyoung Yang, Jungwon KimThis review highlights recent advances in the allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis, based on diverse mechanistic pathways.To cite […]Etikala Ashok
- Azirine-enabled regioselective synthesis of N-alkyl pyrazoles and indole–pyrazole conjugates via Cu-catalysed N–N bond formation May 15, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00123H, PaperAnjali Chaturvedi, Vishal Sharma, Pankaj Sharma, Manpreet Singh, Chandi C. Malakar, Ravindra Rawal, Virender SinghAn efficient and sustainable strategy for the regioselective synthesis of a new class of aliphatic N-substituted pyrazoles has been developed, using azirine-2H-carbaldehydes as versatile building blocks.To cite this article before page numbers are assigned, […]Anjali Chaturvedi
- Unexpected pyrazine ring annulation in the Cu-catalyzed reaction of aryl bromides with 1,2-diamines. Synthesis of novel pyrazino[2,3-f]perimidine fluorophores May 14, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00354K, PaperAndrey L. Dyatlov, Ekaterina A. Filatova, Aleksandr Shcherbatykh, Oleg Demidov, Anna V. GulevskayaCu(I)-catalyzed N-arylation reaction of indole (or carbazole) with 6-bromo-1,3-dimethyl-1H-perimidin-2(3H)-one utilizing diamine ligands is unexpectedly accompanied with the pyrazine ring annulation. The optimal conditions and scope of the latter process were...The content of this RSS Feed (c) […]Andrey L. Dyatlov
- Hβ zeolite mediated sustainable solvent free synthesis of indole-2-carboxylic esters May 13, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00574H, PaperKrishna Sai Gajula, Sai Teja Avusali, Pragati Rathore, Imran Mohammad, Khairunnisa Begam Mahammad, Sreepriya Vedantam, Narender NamaThis study presents a novel, sustainable approach for the synthesis of indole-2-carboxylic esters using H-beta zeolite as a heterogeneous catalyst under solvent-free conditions. The method employs readily available 2-vinyl anilines...The content of […]Krishna Sai Gajula
- Transition Metal-free Chemoselective Synthesis of C3-Styryl Functionalized Di-/tri-substituted Pyrrole Derivatives and Estimation of their Antimicrobial Properties May 13, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00594B, PaperJyoti ., Anshu Singh, Nishant ., Sonu Kumar, C. Malakar, Somesh Baranwal, Virender SinghWe have devised a simple and efficient transition-metal-free approach for the synthesis of styryl-linked di- and tri-substituted pyrrole derivatives. The reaction proceeds in a highly chemoselective manner to efficiently deliver...The content of this RSS Feed […]Jyoti .
- One-Step Synthesis of Zolpidem and Its Analogues via Visible Light Induced Coupling of Imidazo[1,2-α]pyridines with 2-Bromoacetamides May 13, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00267F, PaperShiyu Zhang, Min Li, Yuanjiu Xiao, Yangjianyun Zhang, Peng Deng, Tao Wu, Chun Xia, Wei Deng, Ze TanA novel and efficient strategy for synthesizing drug Zolpidem and its analogues via the coupling of imidazo[1,2-α]pyridines with 2-bromoacetamides under blue LED irradiation has been developed. Starting from two commercially...The content […]Shiyu Zhang
- Bovine serum albumin: an effective and eco-friendly biocatalyst for one-pot, three-component synthesis of valuable imidazole N-oxides in H2O–EtOH medium May 13, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01970B, PaperKoustav Singha, Imran Habib, Pintu Pratihar, Dilip Kumar Maiti, Mossaraf HossainA one-pot, three-component reaction procedure for the synthesis of valuable bioactive imidazole N-oxide derivatives, using the biocatalyst BSA with the application of an incubator shaker in a water–ethanol (4:6) solvent mixture, has been developed.To cite this article before page numbers […]Koustav Singha
- DFT Investigation of 2-Aminothiazole-Catalyzed Five-Component Reaction of CO2 /Amines/Aldehydes: Multi-Species Synergistic Activation and Chemoselective Control in N-Methylation May 12, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00185H, PaperXue Zhang, Qin Yu, Ying Zhou, Hua Zhi, Weiwei Gu, Li Li, Jiyang ZhaoThis study employs density functional theory (DFT) calculations to elucidate the mechanism of a five-component reductive amination reaction involving aldehydes, amines, CO2, BH3•NMe3, and 2-aminothiazole-derived catalysts, with a central focus...The content of this RSS Feed […]Xue Zhang
- Construction of P-stereogenic phosphine oxides via Lewis base-catalyzed enantioselective O-Boc protection May 11, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00546B, CommunicationYike Wang, Xingkuan Chen, Jianfeng XuA Lewis base-catalyzed enantioselective O-Boc protection strategy for the construction of P-stereogenic phosphorus compounds has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYike Wang
- Diverse structural roles of ferrocene in mediating ferroptosis induction by ML162 May 11, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00389C, PaperJing Wang, Wei Li, Zeqi Zhu, Ruicheng Lv, Xuejing Fan, Xiaomin Zhang, Yong WangDiversified ferrocene-appended ML162 derivatives as potent ferroptosis inducers.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryJing Wang
- Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00581K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Çetin Çelik, Naoko Kakusho, Tianyu Xu, Sung Sik Lee, Naoko Yoshizawa-Sugata, Hisao Masai, Yoko YamakoshiThree water-soluble porphyrins with tetra-cationic imidazolium groups were synthesized and assessed for complexation with human telomeric guanine-quadruplex (G4) DNA. […]Çetin Çelik
- π-Spacer Effects in 2,6-Disubstituted BODIPY Fluorophores for Mitochondrial Imaging May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00119J, PaperCharutha Kalarikkal, Poonam Rani, Chinna Ayya Swamy PothulapaduMitochondria are highly dynamic subcellular organelles that serve as central hubs of energy metabolism, signaling, and stress regulation, and their dysfunction is closely linked with a wide range of diseases....The content of this RSS Feed (c) The Royal Society of ChemistryCharutha Kalarikkal
- Diastereoselective synthesis of 1,4,8-trisubstituted perhydroquinolines as novel kappa receptor agonists May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00422A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lea Flämig, W Felix Zhu, Katharina Hoffmann, Constantin Gabriel Daniliuc, Dirk Schepmann, Frank Glorius, Marcel Bermúdez, Karin Loser, Bernhard WuenschAgonists of the kapppa-opioid receptor are useful drugs for the treatment of severe pain, […]Lea Flämig
- Palladium-Catalysed Regioselective [4+2] Annulation to Access Silatetralin-1-amines May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00525J, CommunicationYan Sun, Ruiqiang Lu, Hang Zhou, Liuzhou Gao, Yidong WangA palladium-catalysed [4+2] annulation of benzosilacyclobutenes with N-allenamides for the synthesis of silatetralin-1-amines is reported. This protocol utilizes N-allenamides as versatile bifunctional reagents, acting as both a two-carbon synthon and...The content of this RSS Feed (c) The Royal Society […]Yan Sun
- Electrocyclization of arylvinyl β-hydroxyacetonitrile to substituted cyanomethyl indene derivatives May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00526H, PaperAmit Kumar, Jagadeesh Babu Nanubolu, Sudhakar GangarajulaWe have explored arylvinyl β-hydroxyacetonitrile as a 4π-electrocyclization precursor to access cyanomethyl indene in the presence of Lewis acids. Next, cyanomethyl indene was further reacted with an aromatic aldehyde to...The content of this RSS Feed (c) The Royal Society of ChemistryAmit Kumar
- Enzyme-free Regioselective Phosphorylation of Ribonucleosides is Promoted by Metal Ions May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00404K, PaperManick Mistri, Biswarup JashElucidating the pathway by which RNA efficiently emerged and persisted under prebiotic conditions remains a fundamental challenge in the origin-of-life research. The molecule capable of bridging the gap between prebiotic...The content of this RSS Feed (c) The Royal Society of ChemistryManick Mistri
- Chiral Recognition of Organoselenium Compounds: An Update May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00355A, Review ArticleMárcio S. Silva, Amanda Goldbeck Gerbaudo, Stella Quadros Fernandes, Danilsa Elisa Sorte QuicaxiamoChiral discrimination and stereochemical characterization are essential for understanding the properties and applications of asymmetric compounds. Although chiral organoselenium chemistry has expanded significantly over the past decades, particularly in the...The content of this RSS Feed […]Márcio S. Silva
- Synthesis of Spirooxindoles by Catalytic Tandem Reaction of 2-Arylidene-1,3-indanediones with 2-(2-Oxoindolin-3-yl)malononitriles May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00433D, PaperPengxin Guo, Da-Ming DuA facile synthetic method has been developed for the synthesis of spirooxindoles bearing benzofuran-1(3H)-one. The Michael addition-triggered tandem cyclization reaction between 2-arylene-1,3-indanediones with 2-(2-oxoindolin-3-yl)malononitriles catalyzed by K2CO3 affording the spirooxindole...The content of this RSS Feed (c) The Royal Society of ChemistryPengxin Guo
- Enantioselective Synthesis of Chiral 1,2-Oxazinane Spiro-oxindoles via Carbene-Catalyzed [3+3] Annulation of Isatin-Derived Nitrones with Enals May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00603E, CommunicationYu Miao, Yang Xiao, Xulin Han, Yao Chen, Feilong Cao, Hongzhi Zhuang, Chunsheng Lin, Yanli Jin, Jianfeng Xu, Xingkuan ChenAn N-heterocyclic carbene (NHC)-catalyzed enantioselective [3+3] annulation of isatin-derived nitrones with α,β-unsaturated aldehydes has been developed. This protocol provides straightforward and efficient access to a variety of chiral 1,2-oxazinane […]Yu Miao
- Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids May 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00650G, CommunicationYue Liu, Zhuo-Jia Gan, Zhong-Yuan Zhang, Huan Zhao, Shao-Yang Li, Gao-Qian Wang, Guo-Dong Chen, Takayoshi Awakawa, Zhi-Qin Cao, Jian-Ming Lv, Dan Hu, Hao GaoA five-gene cluster for biosynthesis of sesteraltererol-type sesterterpenoids were identified. Among them, the sesterterpene synthase AasA catalyzes formation of sesteraltererol as the known terpene synthase […]Yue Liu
- Recent advances in allylic and vinylic C–H bond functionalization of simple alkenes via visible-light photocatalysis May 17, 2026
