RSC – Org. Biomol. Chem. latest articles- Correction: Nickel-catalyzed reductive coupling of 2-pyridyl esters with unactivated alkyl chlorides: a universal synthesis of aryl–alkyl and dialkyl ketones via dynamic halide exchange July 1, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90084K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cong Guo, Zhen-Ying Wang, Wen-Heng Liu, Shi-Zheng Liu, Yi-Zheng Cheng, Qiang Li, Jianmin DouTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Cong Guo
- G4-SLSELEX-Seq-driven discovery of G4-specific targeting L-RNA aptamer with unique structure features July 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00526D, CommunicationTian-Ying Wu, Chun Kit KwokWe integrate sequence-guided library design into G4-SLSELEX-Seq, expanding its application in aptamer selection against DNA G-quadruplexes (dG4s). This strategy identifies L-Apt.G3, the first L-RNA aptamer exhibiting low nanomolar binding affinity...The content of this RSS Feed (c) The Royal Society of ChemistryTian-Ying Wu
- Production of subtilosin A in E. coli: insights into the head-to-tail macrocyclization July 1, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01816H, CommunicationYifei Jia, Yuanjun Han, Wenning Wang, Qi ZhangThe metalloenzymes AlbE and Alb are both essential for forming the macrocyclic ring structure of subtilosin A, the canonical member of the sactipeptide family.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Yifei Jia
- Selective Recognition and Sensing of Biologically Important Phosphates Using Triptycene-Based Anion Receptors July 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00760G, PaperAhmad Farouk Kassir, Daniel Lupp, Jakub Grabowski, Jarosław M. Granda, Janusz JurczakThe principal aim of supramolecular chemistry is to design receptors that exhibit a level of selectivity and efficiency comparable to biological receptors and enzymes. Despite recent advances in the field,...The content of this RSS Feed (c) The […]Ahmad Farouk Kassir
- Regioisomeric Branched Trisaccharides: A Combined Synthetic, Biological, and Computational Approach to Understand Details of FimH-Mediated Bacterial Adhesion July 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00927H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ingo vom Sondern, Thisbe K. LindhorstCarbohydrate-mediated interactions are crucial in many biological processes, including microbial adhesion and infections, where glycan recognition is often governed by the three-dimensional presentation of saccharide ligands. In this […]Ingo vom Sondern
- Conformational properties of alkyl glucosyl sulfones in solution† July 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB02056A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jesús Trujillo Vázquez, Carlos A. Sanhueza, Rosa Lelia DortaThe conformational properties of ester-protected alkyl glucosyl sulfones were studied by means of nuclear magnetic resonance (NMR) and circular dichroism (CD). The equilibrium about the […]Jesús Trujillo Vázquez
- Improvement of N-benzoylation catalysis driven by an amyloid–substrate complex July 1, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00593K, PaperKai Yamamoto, Taka Sawazaki, Youhei SohmaCatalysis driven by an amyloid–substrate complex has been improved by derivatizing an amyloid catalyst, modulating its morphology, and using an additive.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Kai Yamamoto
- One-Pot Synthesis of Ferrocenyl-Substituted Allylamine Derivatives by Three-Component Reaction of α-(hydroxy) Alkyl Ferrocenes, Aldehydes and Secondary Amines July 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00652J, PaperHao Yang, Jia-An Zheng, Hui Yuan, Meimei Zhang, Wei-Wei ZHang, Zi-Qiang Wang, Jiaxin He, Yifan Ouyang, Yanru Fan, Yu Huang, Qi-Peng ZhaoWe report an efficient one-pot three-component synthesis of ferrocenyl-substituted allylamine derivatives with α-(hydroxy) alkyl ferrocenes, aldehydes and amines. The advantages of this method are catalyst-free, wide substrate […]Hao Yang
- Selenium Dioxide-Mediated Oxidative Annulation of Sufonyl o-Hydroxyacetophenones with Acetophenones. One-pot Synthesis of Aurone Analogs July 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00989H, PaperMeng-Yang Chang, Yu-Hsuan LiuSelenium dioxide-mediated one-pot oxidative annulation of sulfonyl o-hydroxyacetophenones with acetophenones generates good yields of aurone analogs in refluxing dioxane under the dry air atmosphere conditions. A plausible mechanism is proposed...The content of this RSS Feed (c) The Royal Society of ChemistryMeng-Yang Chang
- Multi-purpose thiocyanate protic ionic liquids in chemodivergent transformations of imidazolidin-2-(thi)one-based diols June 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00709G, PaperValery P. Ermolaev, Nina K. Ratmanova, Vladimir Vladimirovich Baranov, Irina I. Levina, Victor N Khrustalev, Olga Alexandrovna Ivanova, Angelina N. Kravchenko, Igor V. Trushkov, Ivan A. AndreevMulti-purpose thiocyanate-containing protic ionic liquids were utilised in concert as a solvent, a Brønsted acidic catalyst, and a nucleophile source for the […]Valery P. Ermolaev
- UV-assisted rearrangement of substituted 3-arylaminopyrazoles with an allomaltol fragment into tricyclic cyclopenta[4,5]pyrrolo[2,3-c]pyrazole derivatives June 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00796H, PaperAndrey N. Komogortsev, Constantine V. Milyutin, Boris V. Lichitsky, Vasily A. MigulinIn this study, an approach for the synthesis of a novel tricyclic system based on photocontraction of 3-arylaminopyrazoles with an allomaltol fragment was elaborated.To cite this article before page numbers are assigned, use the DOI form of […]Andrey N. Komogortsev
- Access to 4-Methylene-phospholenes through BF3•Et2O Catalyzed Isomerization of 3,4-Dimethylphosphole Sulfides June 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00940E, CommunicationMeng Xiao, Yingqiang Wang, Li-Hui Chen, Rongqiang TianWe have developed a practical synthetic approach to 4-methylene-phospholene derivatives through BF₃•Et₂O-catalyzed isomerization of 3,4-dimethylphosphole sulfides. The reaction simultaneously establishes a P-stereocenter while performing skeletal rearrangement. The transformation is enabled...The content of this RSS Feed (c) The Royal Society of ChemistryMeng Xiao
- From Carboxylic Acids or Their Derivatives to Amines and Ethers: Modern Decarboxylative Approaches for Sustainable C–N and C–O Bond Formation June 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00748H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Weidan Yan, Tian Tian, Yasushi NishiharaAmines and ethers represent essential structural motifs in pharmaceuticals, natural products, organic materials, and catalytic systems. The development of novel, environmentally friendly, and cost-effective strategies for constructing […]Weidan Yan
- Synthesis of Benzo[d,e]quinoline-Spiro-Succinimides via Rhodium-Catalyzed C–H Activation/Annulation of 1-Naphthylamides with Maleimides June 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00825E, CommunicationSubhash Chandra Ghosh, Raj N. Patel, Dharmik M. Patel, Dinesh Gopichand Thakur, NILESH B. RATHOD, SACHIN D. PATEL, Mahesh A. SonawaneThis study unveils the first rhodium-catalyzed synthesis of benzo[d,e]quinoline-spiro-succinimides C–H activation/annulation of 1-naphthylamides with maleimides, utilizing picolinamide as a directing group. The method boasts broad scope, excellent yields, […]Subhash Chandra Ghosh
- Peptide cyclization via late-stage functionalization of tryptophan by sulfonium June 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00776C, PaperYusong Han, Jia Chen, Shan Feng, Mingxuan WuCyclic peptides play important biological functions in natural products and peptide drugs. Therefore, the development of synthesis methods for cyclic peptides is essential. In recent years, tryptophan-mediated cyclic peptides are...The content of this RSS Feed (c) The Royal Society of ChemistryYusong Han
- Decoding the [3 + 2] cycloaddition of a furan–imine oxide with styrene: mechanism, selectivity and bioactivity June 29, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00658A, PaperSofiane Benmetir, Mohamed Chellegui, Raad Nasrullah Salih, Lakhdar Benhamed, Ines Salhi, Haydar A. Mohammad-Salim, Jesus Vicente de Julián-OrtizUsing MEDT and DFT, we studied the [3 + 2] cycloaddition of imine oxide and styrene. The meta–endo adduct forms via a non-polar, asynchronous one-step path. It binds 1CIN protease well […]Sofiane Benmetir
- Asymmetric [3+3] Annulation of 3-Hydroxyquinolin-2-ones via NHC Organocatalysis June 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00848D, CommunicationHeping Li, Weijun Yao, Zhen WangAn efficient N-heterocyclic carbene (NHC)-catalyzed asymmetric [3+3] annulation, followed by a base-promoted ring-opening sequence, has been developed. This methord employs 2-bromoenals and 3-hydroxyquinolin-2(1H)-ones to construct enantioenriched quinoline derivatives with moderate...The content of this RSS Feed (c) The Royal Society of ChemistryHeping Li
- RNA Mango-based Sensors for Lead June 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00765H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Annyesha Biswas, Saurja DasGuptaLead (Pb2+) toxicity poses a serious threat to human health and remains a global concern; therefore, there is a critical need for the development of easy-to-use and cost-effective tools for...The […]Annyesha Biswas
- Mild and Efficient Construction of Nitrogen-Containing Heter-ocycles from Ortho-Ethynylbenzaldehydes and Anilines June 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00634A, PaperJuan Zhao, Huimin Qian, You Zi, Shun-Jun Ji, Xiao-Ping XuA mild and transition-metal-free strategy for the synthesis of isoindolin-1-imines and isoquinolinium salts has been developed using ortho-ethynylbenzaldehydes and anilines. HFIP was employed as an effective promoter, facilitating nucleophilic addition...The content of this RSS Feed (c) The Royal Society […]Juan Zhao
- Combining synthetic biology with synthetic electrochemistry to expand the chemical space of the indolocarbazole family June 26, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00766F, PaperLe-Le Zhu, De-Gao Wang, Luo Niu, Yue-Zhong Li, Hai-yan Sui, Changsheng WuUsing the synergistic advantages of synthetic biology and electrochemistry, we present an environmentally benign approach to indole-carbazole synthesis. This new green synthesis strategy has broad prospects in the future.To cite this article before page numbers are assigned, […]Le-Le Zhu
- Correction: Nickel-catalyzed reductive coupling of 2-pyridyl esters with unactivated alkyl chlorides: a universal synthesis of aryl–alkyl and dialkyl ketones via dynamic halide exchange July 1, 2025
