RSC – Org. Biomol. Chem. latest articles- Studies Directed Towards the Synthesis of a Naturally Occurring Sesquiterpene, 4-Deoxy-10-Oxodihydrobotrydial by a Ti(III)-Mediated Radical Cyclization April 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00334F, PaperKalpesh Ananda Khude, Tushar Kanti ChakrabortyThe Cp2TiCl-mediated opening of epoxides in α,β-unsaturated ester-appended substrates leads to a cascading 5-exo-trig radical cyclization followed by lactonization yielding bicyclic lactone rings. Leveraging this strategic approach has become crucial...The content of this RSS Feed (c) The Royal Society of ChemistryKalpesh Ananda Khude
- CSA-catalyzed three-component synthesis of 6-aryl-6H-chromeno[4,3-b]quinolines April 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00383D, PaperMukesh Kumar, Komal Yadav, Satyajit Singh, Anil Rangnath Pawar, Mrinalini Singh, Parameswar Krishnan Iyer, Abu Taleb KhanA simple and efficient one-pot three-component protocol has been developed for the synthesis of diverse 6-aryl substituted 6H-chromeno[4,3-b]quinoline derivatives from aromatic anilines, salicylaldehydes, and cinnamaldehydes under (±)-camphorsulfonic acid catalysis.To cite this article […]Mukesh Kumar
- Hydrazine hydrate facilitates efficient synthesis of cyclodipeptides for antibacterial screening April 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00499G, PaperZhikun Lei, Chuanbao Wang, Yu Du, Yaxin Wang, Jinkui Teng, Xiaoping Guo, Yun-Bao Jiang, Xiaosheng YanWe report a facile and efficient strategy for synthesizing cyclodipeptides through hydrazine hydrate-mediated cyclization of dipeptide esters under exceptionally mild conditions (room temperature, ethanol). This operationally simple protocol enables the...The content of this […]Zhikun Lei
- Brønsted acid catalyzed multicomponent synthesis of N-arylindole and N-arylbenzo[e]indole April 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00598E, PaperMuhammad Kamran Farooqi, Shou-Jin Xiao, Zhen Liu, Minghao LiThe most preferred heterocyclic indole core was de novo assembled by a multicomponent reaction (MCR) from inexpensive and broadly available anilines, 4-hydroxycyclohexanone or 2-tetralone, and 2,2-dimethoxyacetaldehyde via an acid catalyzed...The content of this RSS Feed (c) The Royal Society of […]Muhammad Kamran Farooqi
- Copper-catalyzed reductive cross-coupling reaction of aryl chlorides and aryl bromides April 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00403B, CommunicationJingyu Wang, Xiongfei Ou, wenxin Fang, Tao Wang, Jingxun YuIn this work, We report a Cu-catalyzed reductive cross-electrophile coupling that enables the direct formation of C-C bonds between aryl chlorides and aryl bromides under reductive conditions. In contrast to...The content of this RSS Feed (c) The Royal Society […]Jingyu Wang
- Crab-shaped tridentate HoQ-Sulidines as bifunctional anionic ligands: empowering asymmetric addition reactions of indoles with β,γ-unsaturated α-ketoesters April 23, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00442C, CommunicationZi-Hong Hu, Xiong-Wei Liu, Wen-Xiu Geng, Ning Wang, Zhen Yao, Rui-Rui Li, Wen-Hui Zhang, Xiong-Li LiuHerein, we report a modular one step synthesis of a new series of crab-shaped bipyridine/hydroxyquinoline-based imidazolidine-type ligands, designated Bpy/HoQ-Sulidines. Among these, the tridentate chiral HoQ-Sulidine ligands could serve as the...The content of this […]Zi-Hong Hu
- Dual Function of Cyanoacetic Acid under Visible Light and Dark Conditions: Templating and Catalyzing the Formation of Unexplored Pyrimidine Derivatives and Evaluation of their Antibacterial Activity April 23, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00345A, PaperShivangi Shivangi, Susital Mal, Subrata DasCyanoacetic acids are developed as efficient substrates for the synthesis of pyrimidine derivatives. Here, we elaborate on the dual role of cyanoacetic acid under both visible-light and dark conditions in...The content of this RSS Feed (c) The Royal Society of ChemistryShivangi Shivangi
- Synthesis and biophysical evaluation of C-5-triazolyl-functionalized morpholino-thymidine analogs April 23, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01995H, PaperAtanu Ghosh, Shreyasi Acharya, Jayanta Kundu, Muthiah Manoharan, Surajit SinhaThe C-5 position of pyrimidines is a known modification site for tuning the biophysical properties of oligonucleotides and nucleic acid duplexes. Consecutive C-5 phenyl triazole motifs in morpholino oligonucleotides boost duplex stability with RNA.To cite this article before page […]Atanu Ghosh
- Backbone extension by methylene insertion as a strategy to restore duplex stability of sulfonamide-linked oligodeoxynucleotides while preserving RNase H activity April 23, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00490C, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kohji Seio, Hiroki Mikagi, Haruka Tanabe, Shigetoshi Tachibana, Yoshiaki Masaki, Eitaro MurakamiExtending the backbone of sulfonamide-linked oligonucleotides restores duplex stability and modulates γ conformation while maintaining RNase H activity, offering an alternative to […]Kohji Seio
- Mild PIFA-Mediated Synthesis of Benzo[4,5]thiazolo[3,2-a]indoles via Oxidative Cyclization April 23, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00393A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xinya Liu, Christine Tran, Olivier Provot, Pascal Retailleau, Abdallah HamzeWe report a novel synthetic approach for the synthesis of benzo[4,5]thiazolo[3,2-a]indoles. This strategy relies on a straightforward cyclization of 1-(2-(methylthio)phenyl)-1H-indoles using (bis(trifluoroacetoxy)iodo)benzene (PIFA) as […]Xinya Liu
- Gold(I)-catalyzed regioselective hydroarylation of indole-ynones: an approach to carbazole derivatives April 22, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00425C, CommunicationYu-Ying Ye, Fang Yang, Wei Hu, Yao Yang, Guo-Jun Pan, Zi-Sheng Chen, Kegong JiA gold(I)-catalyzed regioselective hydroarylation of indole-ynones to various carbazole derivatives 3 and 4 under mild conditions is reported. This reaction involves a 5-endo-dig umpolung arylation/migration process.To cite this article before page numbers are assigned, use […]Yu-Ying Ye
- Synthesis of 2-aminobenzothiazole substituted indole via DBU catalyzed addition of indole and benzothiazolimine April 22, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00152A, PaperXiangjia Song, Ya-Xiong Wang, Xin-Sheng Geng, Jing-Jing Zhang, Yu Yang, Minmin Zhang, Hongfeng Yu, Ningning ZhaoA DBU-catalyzed Mannich reaction between indoles and benzothiazolimines has been developed, providing an efficient and practical approach to a series of 2-aminobenzothiazole substituted indoles with potential pharmaceutical relevance. Under mild...The content of this […]Xiangjia Song
- A modular semi-synthetic approach to form a DHA-like polyunsaturated ether lipid with 15-lipoxygenase-1 substrate activity April 21, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00245E, PaperMina Bathen, Svanur Sigurjónsson, Karl E. Malterud, Daniel H. Hasselstrøm, Osman Gani, Anders Vik, Haraldur G. Gudmundsson, Gudmundur G. Haraldsson, Trond V. HansenIn this work a docosahexaenoic acid-like-methoxylated ether lipid was synthesised using a novel semi-synthetic approach, from natural docosahexaenoic acid and commercially available (2′S)-epichlorohydrin and (2R)-solketal.To cite […]Mina Bathen
- Asymmetric Oxidative Rearrangement of Tetrahydro-β-Carbolines Catalyzed by Anionic Stereogenic-at-Cobalt(III) Complexes April 21, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00260A, PaperBin-Bin Song, Zhen-Jiang Yu, Zi-Mu Liu, Qiongqiong Zhu, Hua-Jie Jiang, Chuan-Zhi Yao, Jie YuAn asymmetric oxidative rearrangement of tetrahydro-β-carbolines catalyzed by anionic stereogenic-at-cobalt(III) complexes has been developed, providing a distinct cobalt-based catalytic mode for the synthesis of chiral spirooxindoles. A range of products...The content of this RSS Feed […]Bin-Bin Song
- H2SO4-catalyzed one-step synthesis of β,β′-carbon-bridged bisBODIPYs from BODIPYs and aldehydes April 20, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00372A, CommunicationHongdi Yuan, Shuangshuang Zhu, Kangle Liu, Yunjie Li, Yuxiang Bai, Yihan Zhang, Xiaoxia Gu, Fan LvA highly regioselective synthesis of β,β′-carbon-bridged bisBODIPYs has been established via an H2SO4-promoted condensation of BODIPYs with aldehydes.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Hongdi Yuan
- 2-Mercaptophenylboronic acid: a superior alternative to 2-mercaptoethanol for thioester hydrolysis April 20, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00342G, PaperKohei Sato, Takaya Yamamoto, Manussada Ratanasak, Yuta Hori, Tenta Ito, Masaya Denda, Tetsuo Narumi, Yasuteru Shigeta, Akira Otaka, Nobuyuki Mase2-Mercaptophenylboronic acid (2-MPBA) facilitates the efficient hydrolysis of peptide thioesters under mild conditions via tandem thiol–thioester exchange and borate-assisted water activation.To cite this article before page numbers are assigned, […]Kohei Sato
- Visible-light-induced Photochemical Synthesis of Spirooxindoles Comprising Carbocyclic Scaffolds April 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00460A, Review ArticleTanzina Firdoushi Borbhuyan, RT Starthring, Sachidulal Biswas, Biplob Borah, L R ChowhanNotwithstanding the notable development achieved in the asymmetric and photochemical construction of spirooxindoles comprising heterocyclic compounds, constructing spirooxindoles containing carbocyclic compounds has not been extensively explored. Drawing inspiration from the...The content of this RSS Feed (c) […]Tanzina Firdoushi Borbhuyan
- Enantioselective [3 + 2] cycloaddition of spirocyclopropyloxindoles with 2-(phthalimido)acrylates: access to spirocyclopentaneoxindoles April 19, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00398B, PaperJing Shan, Zhen-Fu Ke, Lei Qin, Bao-Dong Cui, Jiang-Yu Zhao, Yong-Zheng ChenA palladium-catalyzed asymmetric [3 + 2] cycloaddition of spirocyclopropyl oxindoles with 2-(phthalimido)acrylate derivatives to afford spirocyclopentane oxindole derivatives in up to 99% yield with 99% ee is developed.To cite this article before page numbers are assigned, use […]Jing Shan
- Photo-induced thio/selenocyanation-annulation-rearrangement of indole-tethered 1,6-enynes April 19, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00481D, CommunicationXueli Wang, Li-Jun Li, Qinqin Yan, Zhenyi Wang, Zexuan Liu, Jingyi Chen, Zhong-Quan Liu, Zejiang LiPhoto-involved mild three-component thiocyanation/selenocyanation-cyclization-rearrangement of indole-tethered 1,6-enynes, NH4SCN/KSeCN, with O2 was developed to access diverse thiocyanated/selenocyanated bicarbonyl pyrrolo[1,2-a]indoles. O2 acted in dual roles (oxidant and dicarbonyl oxygen source). The rearrangement...The content of this […]Xueli Wang
- Phosphine-mediated [2 + 1] cyclization of coumarins for the efficient construction of cyclopropa[c]coumarin scaffolds April 19, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00204H, CommunicationMin Xiang, Xing-Xing Dai, Guang-Wei Wang, Yun-Qing Jia, Li-Wen ShenA phosphine-mediated [2 + 1] cyclization of coumarins with α-keto esters or isatins enables the construction of cyclopropa[c]coumarin scaffolds under mild conditions, exhibits a broad substrate scope, and can be readily scaled to gram quantities.To cite this article before […]Min Xiang
- Studies Directed Towards the Synthesis of a Naturally Occurring Sesquiterpene, 4-Deoxy-10-Oxodihydrobotrydial by a Ti(III)-Mediated Radical Cyclization April 26, 2026
