RSC – Org. Biomol. Chem. latest articles- Pyridines with Adamantane Fragments and Their 1,2,4-Triazine Analogues as Anti-Quorum-Sensing Agents, Synthesis and Molecular Docking Tháng 6 26, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00492J, PaperYaroslav K. Shtaitz, Evgeny D Ladin, Kseniya D Krasnoperova, Ivan A Balin, Anton N. Tsmokalyuk, Vasiliy S. Gaviko, Kirill V. Grzhegorzhevski, Dmitry S Kopchuk, Grigory V. ZyryanovDue to the increasing a resistance of bacterial strains to conventional antibiotics, there is an urgent need to develop alternative antibacterial agents […]Yaroslav K. Shtaitz
- Oxidative Electrochemical Addition of Cyclic 1,3-Dicarbonyls to Alkenes Tháng 6 26, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00755D, CommunicationOphélie Montiège, Elisa Zuo, Jean-François Brière, Hélène BeucherAn electrochemical radical reaction between cyclic 1,3-dicarbonyls and alkenes is reported herein to give di- and tricyclic dihydrofuran derivatives. This methodolgy proceeds via a direct oxidative addition/cyclization sequence without the...The content of this RSS Feed (c) The Royal Society of ChemistryOphélie Montiège
- Exploring synthetic routes to 6-functionalized 4-azaspiro[2.3]hexanes Tháng 6 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01434D, PaperWei Huang, Kangqiao Wen, Scott T. LaughlinAzaspirohexanes are promising scaffolds for the synthesis of piperidine bioisosteres in medicinal chemistry.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryWei Huang
- Metal-free O–H insertion enables access to heterocycle-rich α-carbonyloxy esters Tháng 6 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00779A, Paper Mohit, Ritika Sharma, Diwan S. RawatA metal- and oxidant-free approach for selective O–H insertion of aryldiazoacetates with heterocyclic carboxylic acids leads to the formation of alpha-carbonyloxy esters in up to 93% yield with wide functional group tolerance.To cite this article before page numbers are assigned, use the […]Mohit
- The direct access to alkenes from HF2C- or Cl3C-substituted arenes and an organo sodium reagent Tháng 6 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00838K, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Paula Knupe-Wolfgang, Gerhard HiltThe unprecedented reaction of an organo sodium reagent, generated in a sodium-packed bed reactor, with (difluoromethyl)- or (trichloromethyl)benzene derivatives provided alkenes in acceptable to good yields.To cite this article before […]Paula Knupe-Wolfgang
- Transition-metal-free three-component synthesis of α-tertiary trifluoromethyl phosphonates from CF3 diazo compounds Tháng 6 24, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00666C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shuangming Zhang, Xianda Wu, Yu-Mei Lin, Shaofeng Wu, Guo Tang, Lei Gong, Ablimit Abdukaderα-Trifluoromethylated phosphonates are highly valued in medicinal chemistry and functional materials, yet their efficient synthesis remains challenging. Herein, we report […]Shuangming Zhang
- Synthesis of polymethylene-linked bis(cyclobutane-fused chromanones) mediated by gold-photocatalysis Tháng 6 24, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00903D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Junying Wang, Steven P Nolan, Vladislav Voloshkin, Luigi Cavallo, Sayan Dutta, yuan zhao, Tommaso Ruggiero, Kristof Van Hecke, Bholanath MaityWe report an efficient gold-mediated energy transfer photocatalytic method for the synthesis of polymethylene-linked […]Junying Wang
- Regio-and Enantioselective Oxidation by CYP108N12: Substrate Scope and Specificity Tháng 6 23, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00617E, PaperJames Joseph De Voss, Julia Beth Buczynski, Peter Giang, Luke Richard Churchman, Stephen G BellGrowing demand for efficient, safe and economically viable catalytic processes has driven increasing interest in using enzymes for large-scale, biocatalytic transformations. Cytochromes P450 are enantio-, regio-and chemo-selective enzymes renowned for...The content of this RSS […]James Joseph De Voss
- Azo Compounds as Key Intermediates in the Synthesis of Cinnolines. Recent Advances Tháng 6 23, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00771F, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xabier Jimenez-Aberasturi, Xabier del Corte, Jesús M. de los Santos, Javier VicarioOver the past decades, azo compounds have emerged as versatile and efficient building blocks for the construction of cinnoline frameworks due […]Xabier Jimenez-Aberasturi
- Palladium-Catalyzed Chelation-Assisted C-H Functionalization of Quinoline Aldehydes to Esters with Mechanistic Insights Tháng 6 22, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00752J, CommunicationSubhash Chandra Ghosh, Anil K Yadav, Dinesh Gopichand Thakur, Mahesh A. SonawaneWe have developed a palladium-catalyzed method for the direct coupling of quinoline-8-carboxaldehyde with aliphatic 1 o , 2 o alcohols and phenols to produce quinoline-8-carboxylate. A catalytically active palladacyclic dimer...The content of this RSS Feed (c) The […]Subhash Chandra Ghosh
- DMSO as a multifunctional reactant in recent organic synthesis Tháng 6 22, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00576D, Review ArticleAnil Rangnath Pawar, Arnab Mandal, Abu Taleb KhanThis review highlights recent advances (2022–2025) in using DMSO beyond a solvent, focusing on metal/metal-free, acid/base-free, photocatalytic, and electrochemical reactions. It emphasizes DMSO as a green C, O, & S synthon in sustainable synthesis.To cite this article before page numbers […]Anil Rangnath Pawar
- Synthesis of 7-(diethylamino)-chromene-fused quinolines and 7-(diethylamino)-4-amino-3-formyl-coumarin derivatives, structural elucidation, and photophysical properties Tháng 6 21, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00880A, PaperNazmul Hosen, Leah M. Case, Sadira L. Dukette, Nishrenika Pokhrel, Karl J. WallaceA simple approach to prepare fluorescence dyes with unusual photophysical properties in an array of solvents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Nazmul Hosen
- Catalytic Synthesis of Saturated Azacycles using Transborylation Tháng 6 21, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00722H, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nojus Cironis, Nathan Mcrae, Jack Stubbs, Sarah L. McOnie, Mohammad Babar, Michael Ingelson, Stephen P. ThomasA simple, catalytic synthesis of pyrrolidines through the intermolecular cyclisation-homologation of azido-butenes was enabled by a hydroboration, 1,2-metallate […]Nojus Cironis
- Electrophilic Alkene Sulfenylation with Alkyl Sulfinates Tháng 6 21, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00670A, PaperFei Xu, Xuexin Han, Jinyun Li, Hongguang Du, Ning ChenAn electrophilic alkene sulfenylation using alkyl sulfinates as readily available sulfur sources has been developed under mild HI activation. Terminal and 1,2-disubstituted alkenes, including cyclic substrates, predominantly undergo electrophilic addition...The content of this RSS Feed (c) The Royal Society […]Fei Xu
- Stereodivergent access to 5–6–5, 5–6–6, and 5–6–7 fused tricyclic indolizidine cores via ring-size-dependent fragmentation of overbred intermediates Tháng 6 18, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00837B, PaperSushil Kumar Ranjan, Kishor Chandra Bharadwaj, Ganesh PandeyA rigid overbred precursor enables stereodivergent access to 5–6–5, 5–6–6, and 5–6–7 fused tricyclic nitrogen frameworks via a ring-size-dependent stereochemical switch and strain-release fragmentation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Sushil Kumar Ranjan
- Single-Step Synthesis of 3,5-diazido 1,2,4-triazole: Environmentally Benign High-Performance Primary Explosives Tháng 6 18, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00777E, PaperSagar Nehe, Srinivas DharavathHerein, we report a single-step synthesis of 3,5-diazido 1,2,4-triazole (DATr) from an inexpensive precursor, overcoming the lengthy synthetic procedures. DATr fully satisfies all required primary explosive characteristics such as high...The content of this RSS Feed (c) The Royal Society of ChemistrySagar Nehe
- Brønsted acid-catalyzed synthesis of benzo[f]indole and naphtho[2,3-b]furan derivatives via an intramolecular cascade isomerization/cyclization/aromatization Tháng 6 18, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00462H, PaperRaj Kamal Sahoo, Sourav Ghosh, Kush Mandal, Asadujjaman Nur, Umasish JanaHerein, we demonstrated a PTSA-catalyzed facile and efficient synthesis of tricyclic benzo[f]indole and naphtho[2,3-b]furan derivatives via a cascade isomerization/cyclisation/aromatisation reaction in good yields.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Raj Kamal Sahoo
- Copper-mediated oxidative deconstruction of polyethylene terephthalate via photoinduced ligand-to-metal charge transfer Tháng 6 18, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00625F, PaperGuangyao Li, Mingsen Han, Zezheng Leng, Yazhi Deng, Jin Liu, Yu Guo, Bin Yang, Jiazhu Li, Feng Liu, Chang-Cheng WangPolyethylene terephthalate (PET) is widely used in daily life due to its excellent properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Guangyao Li
- A Straightforward Access to Specific Bisindole Systems Related to Caulersin Tháng 6 18, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00692B, CommunicationFei Hu, Yong-tian Yang, Fei Yu, Mei Xu, Sheng LiuTwo sets of starting materials were tested to trigger domino processes involving C3 insertion of indole fragments and C-C migration, thereby enabling the synthesis of the specific bisindole framework with...The content of this RSS Feed (c) The Royal Society […]Fei Hu
- Replication of chiral α-hydroxy acids via induction and amplification through an enantioenriched cyanohydrin conglomerate Tháng 6 17, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00652C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tsuneomi Kawasaki, Naoya Takamatsu, Shohei Aiba, Yong Du Kim, Kohei Niikura, So Okumura, Takumi Inoue, Yosuke Tsunomori, Yudai Tanaka, Masaki Kato, Kenji Nemoto, Yuji TokunagaAbsolute asymmetric synthesis of cyanohydrins has been achieved without […]Tsuneomi Kawasaki
- Pyridines with Adamantane Fragments and Their 1,2,4-Triazine Analogues as Anti-Quorum-Sensing Agents, Synthesis and Molecular Docking Tháng 6 26, 2026
