RSC – Org. Biomol. Chem. latest articles- Crab-shaped tridentate HoQ-Sulidines as bifunctional anionic ligands: empowering asymmetric addition reactions of indoles with β,γ-unsaturated α-ketoesters Tháng 4 23, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00442C, CommunicationZi-Hong Hu, Xiong-Wei Liu, Wen-Xiu Geng, Ning Wang, Zhen Yao, Rui-Rui Li, Wen-Hui Zhang, Xiong-Li LiuHerein, we report a modular one step synthesis of a new series of crab-shaped bipyridine/hydroxyquinoline-based imidazolidine-type ligands, designated Bpy/HoQ-Sulidines. Among these, the tridentate chiral HoQ-Sulidine ligands could serve as the...The content of this […]Zi-Hong Hu
- Backbone extension by methylene insertion as a strategy to restore duplex stability of sulfonamide-linked oligodeoxynucleotides while preserving RNase H activity Tháng 4 23, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00490C, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kohji Seio, Hiroki Mikagi, Haruka Tanabe, Shigetoshi Tachibana, Yoshiaki Masaki, Eitaro MurakamiExtending the backbone of sulfonamide-linked oligonucleotides restores duplex stability and modulates γ conformation while maintaining RNase H activity, offering an alternative to […]Kohji Seio
- Dual Function of Cyanoacetic Acid under Visible Light and Dark Conditions: Templating and Catalyzing the Formation of Unexplored Pyrimidine Derivatives and Evaluation of their Antibacterial Activity Tháng 4 23, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00345A, PaperShivangi Shivangi, Susital Mal, Subrata DasCyanoacetic acids are developed as efficient substrates for the synthesis of pyrimidine derivatives. Here, we elaborate on the dual role of cyanoacetic acid under both visible-light and dark conditions in...The content of this RSS Feed (c) The Royal Society of ChemistryShivangi Shivangi
- Synthesis and biophysical evaluation of C-5-triazolyl-functionalized morpholino-thymidine analogs Tháng 4 23, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01995H, PaperAtanu Ghosh, Shreyasi Acharya, Jayanta Kundu, Muthiah Manoharan, Surajit SinhaThe C-5 position of pyrimidines is a known modification site for tuning the biophysical properties of oligonucleotides and nucleic acid duplexes. Consecutive C-5 phenyl triazole motifs in morpholino oligonucleotides boost duplex stability with RNA.To cite this article before page […]Atanu Ghosh
- Mild PIFA-Mediated Synthesis of Benzo[4,5]thiazolo[3,2-a]indoles via Oxidative Cyclization Tháng 4 23, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00393A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xinya Liu, Christine Tran, Olivier Provot, Pascal Retailleau, Abdallah HamzeWe report a novel synthetic approach for the synthesis of benzo[4,5]thiazolo[3,2-a]indoles. This strategy relies on a straightforward cyclization of 1-(2-(methylthio)phenyl)-1H-indoles using (bis(trifluoroacetoxy)iodo)benzene (PIFA) as […]Xinya Liu
- Gold(I)-Catalyzed Regioselective Hydroarylation of indole-Ynones: An Approach to Carbazole Derivatives Tháng 4 22, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00425C, CommunicationYu-Ying Ye, Fang Yang, Wei Hu, Yao Yang, Guo-Jun Pan, Zi-Sheng Chen, Kegong JiA gold(I)-catalyzed regioselective umpolung hydroarylation of indole-ynones to dihydrocarbazoles is reported. When a vinyl group is installed at the carbonyl end, ynone umpolung arylation is achieved, followed by tandem Nazarov...The content of this RSS Feed […]Yu-Ying Ye
- Synthesis of 2-aminobenzothiazole substituted indole via DBU catalyzed addition of indole and benzothiazolimine Tháng 4 22, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00152A, PaperXiangjia Song, Ya-Xiong Wang, Xin-Sheng Geng, Jing-Jing Zhang, Yu Yang, Minmin Zhang, Hongfeng Yu, Ningning ZhaoA DBU-catalyzed Mannich reaction between indoles and benzothiazolimines has been developed, providing an efficient and practical approach to a series of 2-aminobenzothiazole substituted indoles with potential pharmaceutical relevance. Under mild...The content of this […]Xiangjia Song
- A modular semi-synthetic approach to form a DHA-like polyunsaturated ether lipid with 15-lipoxygenase-1 substrate activity Tháng 4 21, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00245E, PaperMina Bathen, Svanur Sigurjónsson, Karl E. Malterud, Daniel H. Hasselstrøm, Osman Gani, Anders Vik, Haraldur G. Gudmundsson, Gudmundur G. Haraldsson, Trond V. HansenIn this work a docosahexaenoic acid-like-methoxylated ether lipid was synthesised using a novel semi-synthetic approach, from natural docosahexaenoic acid and commercially available (2′S)-epichlorohydrin and (2R)-solketal.To cite […]Mina Bathen
- Asymmetric Oxidative Rearrangement of Tetrahydro-β-Carbolines Catalyzed by Anionic Stereogenic-at-Cobalt(III) Complexes Tháng 4 21, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00260A, PaperBin-Bin Song, Zhen-Jiang Yu, Zi-Mu Liu, Qiongqiong Zhu, Hua-Jie Jiang, Chuan-Zhi Yao, Jie YuAn asymmetric oxidative rearrangement of tetrahydro-β-carbolines catalyzed by anionic stereogenic-at-cobalt(III) complexes has been developed, providing a distinct cobalt-based catalytic mode for the synthesis of chiral spirooxindoles. A range of products...The content of this RSS Feed […]Bin-Bin Song
- 2-Mercaptophenylboronic Acid: A Superior Alternative to 2-Mercaptoethanol for Thioester Hydrolysis Tháng 4 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00342G, PaperKohei Sato, Takaya Yamamoto, Manussada Ratanasak, Yuta Hori, Tenta Ito, Masaya Denda, Tetsuo Narumi, Yasuteru Shigeta, Akira Otaka, Nobuyuki MaseHerein, we demonstrate that 2-mercaptophenylboronic acid promotes the hydrolysis of peptide alkyl thioesters via thiol-thioester exchange to form a reactive aryl thioester intermediate, followed by borate-assisted hydrolysis of the […]Kohei Sato
- H₂SO₄-Catalyzed One-Step Synthesis of β,β′-Carbon-Bridged bisBODIPYs from BODIPYs and Aldehydes Tháng 4 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00372A, CommunicationHongdi Yuan, Shuangshuang Zhu, Kangle Liu, Yunjie Li, Yuxiang Bai, Yihan Zhang, Xiaoxia Gu, Fan LvAn H2SO4-promoted condensation reaction between BODIPYs and aldehydes has been established, enabling a straightforward and versatile approach for the highly regioselectivity synthesis of β,β′-carbon-bridged bisBODIPYs. This one pot method efficiently...The content of this […]Hongdi Yuan
- Visible-light-induced Photochemical Synthesis of Spirooxindoles Comprising Carbocyclic Scaffolds Tháng 4 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00460A, Review ArticleTanzina Firdoushi Borbhuyan, RT Starthring, Sachidulal Biswas, Biplob Borah, L R ChowhanNotwithstanding the notable development achieved in the asymmetric and photochemical construction of spirooxindoles comprising heterocyclic compounds, constructing spirooxindoles containing carbocyclic compounds has not been extensively explored. Drawing inspiration from the...The content of this RSS Feed (c) […]Tanzina Firdoushi Borbhuyan
- Phosphine-mediated [2 + 1] cyclization of coumarins for the efficient construction of cyclopropa[c]coumarin scaffolds Tháng 4 19, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00204H, CommunicationMin Xiang, Xing-Xing Dai, Guang-Wei Wang, Yun-Qing Jia, Li-Wen ShenA phosphine-mediated [2 + 1] cyclization of coumarins with α-keto esters or isatins enables the construction of cyclopropa[c]coumarin scaffolds under mild conditions, exhibits a broad substrate scope, and can be readily scaled to gram quantities.To cite this article before […]Min Xiang
- Enantioselective [3 + 2] cycloaddition of spirocyclopropyloxindoles with 2-(phthalimido)acrylates: access to spirocyclopentaneoxindoles Tháng 4 19, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00398B, PaperJing Shan, Zhen-Fu Ke, Lei Qin, Bao-Dong Cui, Jiang-Yu Zhao, Yong-Zheng ChenA palladium-catalyzed asymmetric [3 + 2] cycloaddition of spirocyclopropyl oxindoles with 2-(phthalimido)acrylate derivatives to afford spirocyclopentane oxindole derivatives in up to 99% yield with 99% ee is developed.To cite this article before page numbers are assigned, use […]Jing Shan
- Photo-induced thio/selenocyanation-annulation-rearrangement of indole-tethered 1,6-enynes Tháng 4 19, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00481D, CommunicationXueli Wang, Li-Jun Li, Qinqin Yan, Zhenyi Wang, Zexuan Liu, Jingyi Chen, Zhong-Quan Liu, Zejiang LiPhoto-involved mild three-component thiocyanation/selenocyanation-cyclization-rearrangement of indole-tethered 1,6-enynes, NH4SCN/KSeCN, with O2 was developed to access diverse thiocyanated/selenocyanated bicarbonyl pyrrolo[1,2-a]indoles. O2 acted in dual roles (oxidant and dicarbonyl oxygen source). The rearrangement...The content of this […]Xueli Wang
- Correction: Synthesis of hexahydroisobenzofuran-1(3H)-ones via pyridine-boryl radical-catalyzed intramolecular cascade cyclization of alkene-tethered cyclobutyl ketones Tháng 4 16, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB90044E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiao-Ye Yang, Hua Huang, Qiong Wu, Yun-Xuan Tan, Ping TianTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Xiao-Ye Yang
- Configurational stability of bis-ortho-methyl Tröger's base: methylene bridge substitution with retention of stereochemistry Tháng 4 16, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00250A, PaperSundaram SureshThe methylene bridge of bis-ortho-methyl Tröger's base was exchanged with formamides with complete transfer of chirality in the presence of POCl3, revealing configurational stability.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Sundaram Suresh
- Direct C–H amination of indoles enabled by tert-butyl chlorosulfonylcarbamate with diisopropylethylamine Tháng 4 16, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00465B, CommunicationYufeng Lin, Xiaomeng Wang, Xiaofei Zhang, Chunhao YangA catalyst-free method for the preparation of Boc-protected 2-aminoindoles was reported. This protocol features simple indole substrates and a readily available nitrogen source under exceptionally simple reaction conditions.To cite this article before page numbers are assigned, use the DOI form of […]Yufeng Lin
- 2-Pyridyl sulfoxide-directed Pd(II)-catalyzed regioselective C2-arylation/alkenylation of indoles Tháng 4 16, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00484A, PaperKanchan Yadav, Ram Singh Jat, Ritesh Singh, Bhupendra Goswami, M. BhanuchandraPd(II)-catalysed regioselective C2-arylation and C2-alkenylation of indoles with iodoarenes and activated and unactivated alkenes, respectively, have been achieved using 2-pyridyl sulfoxide as the DG at the C-3 position of N-substituted indoles.To cite this article before page numbers are […]Kanchan Yadav
- Synthesis of furoquinolines from 2-alkenylanilines via anodic dearomatization and cascade cyclization Tháng 4 16, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00390G, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xin Feng, Renhua Fan, Qiuqin HeA facile synthesis of dihydrofuro[2,3-g]quinolinones has been achieved via anodic dearomatization and one-pot cascade cyclization, addressing the limited synthetic methods for this understudied furoquinoline scaffold.To cite this article […]Xin Feng
- Crab-shaped tridentate HoQ-Sulidines as bifunctional anionic ligands: empowering asymmetric addition reactions of indoles with β,γ-unsaturated α-ketoesters Tháng 4 23, 2026
