RSC – Org. Biomol. Chem. latest articles- Transition-metal-free C-H arylation of unactivated arenes with aryl halides enabled by potassium tert-butoxide/gatifloxacin hydrochloride catalyst Tháng 6 14, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00624H, PaperDake Song, Zhirui HaoA transition-metal-free protocol for the efficient construction of biaryl frameworks via direct C–H arylation of unactivated arenes with aryl halides is reported, enabled by a synergistic potassium tert-butoxide (t-BuOK)/gatifloxacin hydrochloride...The content of this RSS Feed (c) The Royal Society of ChemistryDake Song
- Metal-Dependent Pathway Selection in Co(III)- and Rh(III)-Catalyzed C–H Activation–Alkyne Coupling: A DFT Study Tháng 6 14, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00325G, PaperYuanjun Song, Ran Fang, Simeng Qi, Liyuan Meng, Lizi YangTransition-metal-catalyzed C–H activation–alkyne coupling represents a powerful strategy for the construction of strained phosphorus-containing heterocycles, yet the mechanistic origins of pathway selection and metal-dependent reactivity remain poorly understood. Herein, a...The content of this RSS Feed (c) The Royal Society […]Yuanjun Song
- Recent Advances in the Total Synthesis of Coumarin-Based Natural Products Tháng 6 14, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00463F, Review ArticleMohd Kamil Hussain, Mohd Aqib, Humaira Parveen, Sayeed Mukhtar, Mona O Albalawi, Kahkashan Begum, Shakir Ahamad, Mohammad SaquibCoumarins represent an important class of oxygenated heterocyclic natural products widely distributed in plants, fungi, and microorganisms. Their remarkable structural diversity ranges from simple oxygenated coumarins to complex fused architectures...The […]Mohd Kamil Hussain
- Rh(III)-catalyzed site selective hydroarylation of maleimides with 5-aryl-1,2,4-oxadiazole frameworks Tháng 6 14, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00177G, PaperSangepu Karthik, Venkata Subba Reddy Basireddy, Mettu Dharani, B. Sridhar, Pannala Padmaja ReddyThe site-selective functionalization of 5-aryl-1,2,4-oxadiazoles with maleimides has been achieved using a catalytic amount of rhodium(III) catalyst to afford a series of succinimide substituted 1,2,4oxadiazole frameworks. This is first example...The content of this RSS Feed (c) […]Sangepu Karthik
- Self-delivering THPC-modified cytochrome c induces cancer cell apoptosis Tháng 6 14, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00487C, CommunicationZipei Tan, Tao Jiang, Zirun Wang, Ning Zhang, Mingming MaTHPC modification converts cytochrome c into a self-delivering anticancer protein.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryZipei Tan
- Study of aza-and diaza-cyclotribenzylidenes conformations Tháng 6 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00727A, PaperArsène Château, Clement Vigier, Karine Jarsale, Remi Legay, Jean-François Lohier, Jana Sopkova de Oliveira Santos, Thomas Cailly, Frédéric Fabis, Emmanuelle DubostThe synthesis of both aza- and diaza-cyclotribenzylidene (CTB-1NH and CTB-2NH respectively), cyclotribenzylidenes functionalized with one or two nitrogen atoms replacing methylene bridges is reported, as well as the […]Arsène Château
- Asymmetric α-amination of aldehydes at low catalytic loading: application to the synthesis of solriamfetol and nateglinide Tháng 6 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00769D, PaperRonak Mehta, Rohtash Kumar, Avinash Avinash, Chandrakumar AppayeeWe report an asymmetric α-amination of aldehydes using a nonsilyl bicyclic secondary amine organocatalyst at 0.1 mol % in the presence of propanoic acid (100 mol %). Catalyst stability toward...The content of this RSS Feed (c) The Royal Society of ChemistryRonak Mehta
- Design, synthesis, and evaluation of trisubstituted bicyclo[2.2.2]oct-2-enes as non-classical isosteres of trisubstituted benzenes Tháng 6 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00798H, PaperChih-Wei Hsu, Wei-Qi Liu, Fang-Jie Shih, Yong-Jin Jheng, Chih-Hui Chou, Yu-Meng Wang, Sung-Fang Chen, John Chu, Woo-Jin YooThe limited availability of polycyclic hydrocarbon scaffolds that accurately mimic the torsional angles of polysubstituted benzenes poses a challenge in bioisostere design. To address this issue, we propose bicyclo[2.2.2]oct-2-enes as...The content […]Chih-Wei Hsu
- Copper-Catalyzed Selective 1,2-Disulfidation of 1,3-Dienes Tháng 6 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00721J, CommunicationHuawen Huang, Pu Che, Shuilin Liu, Ning LiuA copper-catalyzed protocol for the regioselective 1,2-bissulfuration of 1,3-dienes has been developed. This transformation utilizes sulfonyl chlorides and thiols as bifunctional sulfur sources, proceeding under mild conditions to afford valuable...The content of this RSS Feed (c) The Royal Society of ChemistryHuawen Huang
- Tunable Electrosynthesis of Functionalized Phenoxazines from Alcohols and P₄S₁₀. Tháng 6 11, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00744A, CommunicationChenpei Yang, Yanan Li, Jin-Song Hu, Yutong Shi, Yan Zhang, Jianan Sun, Peng QianA green and efficient electrochemical strategy has been developed for the three-component reaction of phenoxazine, alcohols and P₄S₁₀ under ambient conditions. Using inexpensive P₄S₁₀ as both the sulfur and phosphorus...The content of this RSS Feed […]Chenpei Yang
- Ferric Chloride Mediated Synthesis, Photophysical and In vitro anti-Alzheimer Properties of 1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)phenyl)-2-(9H-fluoren-9-ylidene)-1-phenylethan-1-imines Tháng 6 10, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00406G, PaperAravamudhan Subhashini, Pramod Gudigenahally Nagaraju, Ponnusamy ShanmugamAmong several Lewis acids tested, ferric chloride has emerged as an efficient Lewis acid catalyst for the reaction of 9-fluorene propargylic alcohols with 2-(7-azaindole-3-methelene) aniline as the nucleophile, affording various...The content of this RSS Feed (c) The Royal Society of ChemistryAravamudhan Subhashini
- Recent Advances in Chemoselective Protein Desulfurization: From VA-044 to Emerging Boron, Photochemical, Iron-Catalyzed, and Ultrasound Methods Tháng 6 10, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00780E, Review ArticleXiaoyang Ding, Chuntong Li, Xinyan Wang, lujun liangNative chemical ligation (NCL) represents a powerful strategy for the chemical synthesis of tailor-made proteins that are difficult to obtain via biological expression systems. Early desulfurization methods, particularly VA-044-based desulfurization,...The content of this RSS Feed (c) The Royal Society of […]Xiaoyang Ding
- Diversity of dye aggregates: Self-assembly of naphthalene-linked chlorophyll dyads dependent on substitution position Tháng 6 10, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00754F, PaperShogo Matsubara, Yusuke Hirose, Tatsuma Ishii, Hitoshi TamiakiChlorosomes, the light-harvesting antennae of green photosynthetic bacteria, exhibit supramolecular structural diversity arising from variations in the chemical structures of their constituent pigments. Although chlorosome models prepared via in vitro...The content of this RSS Feed (c) The Royal Society of ChemistryShogo Matsubara
- Aza-Prins Type Cyclisation of Vinyl Bis-Sulfide-Tethered Amines for the Collective Synthesis of Piperidine, Indolizidine and Isoindolone Natural Products Tháng 6 9, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00883F, CommunicationSantosh J. Gharpure, Rakhi Yadav, Krishna Suraj Gupta, Girish P KadamHerein, we report a Brønsted acid-mediated inter- and intramolecular aza-Prins cyclisation of vinyl bis-sulfide substituted amines, providing an efficient and highly stereoselective approach to piperidine, indolizidine, and isoindolone frameworks. This...The content of this RSS Feed (c) The Royal […]Santosh J. Gharpure
- Experimental and computational insights into the unexpected Type I dyotropic rearrangement within N-clovanylamides synthesised via microwave-assisted SnII-catalysis Tháng 6 9, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00656F, PaperAntonio Ruano-González, Ana A. Pinto, Dhionne C. Gomes, Rosa Duran-Patrón, Rosario Hernández-Galán, Andrés G. Algarra, Antonio J. Macías-Sánchez, Isidro G. ColladoA Sn(II)-catalysed Ritter synthesis of clovanylamides revealed an interesting Type I dyotropic rearrangement, involving a migrating bromine atom, to explain the unexpected convergence of skeletal isomers.To cite this […]Antonio Ruano-González
- Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks Tháng 6 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00839A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Victoria Sodré, Goran M. M. Rashid, Boriana V. Yotzova, Timothy D. H. BuggRhodococcus jostii glutamate dehydrogenase 5 (GDH5) assists in the cyclisation of pyridine-dicarboxylic acids derived from lignin.To cite this article before page […]Victoria Sodré
- Metalloradical and photoredox manifolds in manganese photocatalysis Tháng 6 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00695G, Review ArticleMaulik Pethani, Yash Dhaduk, Shivam Vispute, Anilkumar Kommoju, Shreeya Dave, Arpan Patel, Kishor Padala, Togati NaveenVisible-light-driven manganese catalysis has emerged as a powerful and sustainable alternative to noble-metal-based photoredox systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Maulik Pethani
- Catalytic regioselective alkylation of oxindoles using diaryl secondary alcohols under homogeneous conditions Tháng 6 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00687F, PaperChibisree Elanchezhian, Nandana Mohan, Mrinal Kanti Das, Saikat ChaudhuriMetal-free alkylation of 2-oxindoles under mild conditions is achieved using DABCO(TfOH)2 and HFIP. The method enables selective N- and C5-functionalization, providing diverse products in excellent yields with broad substrate scope.To cite this article before page numbers are assigned, use the […]Chibisree Elanchezhian
- Palladium-catalyzed Synthesis of S-Aryl Thiocarbamate via Desulfurative C-S Cross-coupling Reaction of Dithiocarbamates Tháng 6 8, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00331A, PaperRahul Mondal, Manas Mondal, Amit SahaA new protocol for synthesizing S-aryl thiocarbamate has been demonstrated here by the desulfurative C-S cross coupling of dithiocarbamate esters with arylsilanes in presence of Pd(II)-catalyst and Cu(II)-oxidant. A series...The content of this RSS Feed (c) The Royal Society of ChemistryRahul Mondal
- Distinct reactivity of aromatic and aliphatic thiols for the efficient synthesis of chromeno[2,3-d]pyrimidine and chromeno[4,3-b]chromene derivatives: mechanistic investigations and reaction scope Tháng 6 7, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00585C, CommunicationSuman Sourabh, Yogesh Bhaskar Singh Tanwer, Raj Rani, Sabyasachi Bhunia, Sanchari Pal, Debjit DasThis study presents three-/two-component cyclization protocol for synthesizing valuable chromeno[2,3-d]pyrimidine and chromeno[4,3-b]chromene derivatives, where aromatic thiols act as nucleophiles and aliphatic thiols serve as reducing agents.To cite this article before page numbers are assigned, use […]Suman Sourabh
- Transition-metal-free C-H arylation of unactivated arenes with aryl halides enabled by potassium tert-butoxide/gatifloxacin hydrochloride catalyst Tháng 6 14, 2026
