RSC – Org. Biomol. Chem. latest articles- Recent advances in the synthesis of multiple helicenes Tháng 7 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00966A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhen Chen, Wei-Chen Guo, Chuan-Feng ChenMultiple helicenes, as helically twisted polycyclic frameworks with extended π-conjugated systems, have attracted growing attention due to their unique topologies, tunable chiroptical properties, and potential applications in […]Zhen Chen
- Electrochemical [3+2] Cycloaddition of Anilines and Enamine ketone: Construction of 3-benzoylindole derivatives Tháng 7 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00831J, PaperYangyang Hu, Chunlei Yu, Ya`nan Ran, Miao Yu, Jingwen Sun, Huiying Liu, Jiahui Zhang, Hai-Jun Wang, Lei LiuThis article describes an eco-friendly and atom-economical electrochemical protocol for the intermolecular [3+2] cyclization to synthesize 3-benzoylindole derivatives in synthetically viable yields. The oxidative annulation proceeds under transition-metal-free and strong-oxidant-free...The content […]Yangyang Hu
- Assembly of 1,3-Diaryl-1H-pyrazoles via Base-Mediated [3+2] cycloaddition Tháng 7 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00907C, CommunicationTenglong Xu, Zimei Zhong, Jianwei Yan, Yi Chen, Aifang Wang, Min Wang1,3-Diaryl-1H-pyrazoles, serving as privileged heterocyclic scaffolds, demonstrate significant application potential in pharmaceutical development, functional materials, and agrochemical industries. This study presents a synthetic strategy based on [3+2] cycloaddition, achieving efficient...The content of this RSS Feed (c) The […]Tenglong Xu
- Double addition of organoaluminum reagents onto nitriles to access diethynyl carbinamines Tháng 7 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00911A, CommunicationMorwenna Pearson-Long, Philippe Bertus, Fabien Boeda, Huong Giang NguyenThe reactivity of organoaluminum reagents with acyl cyanohydrins was studied using two methods for preparing the nucleophilic species. Mild and chemoselective conditions were developed and the unprecedented double addition of...The content of this RSS Feed (c) The Royal Society of […]Morwenna Pearson-Long
- Formal total synthesis of (±)-liphagal Tháng 7 17, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00871A, PaperSora Yotsui, Takehiko YoshimitsuThe combination of copper-catalyzed benzofuran formation via quinone–hydroquinone redox chemistry, silver-catalyzed B-ring construction, and stereoconvergent C8 functionalization culminated in a new formal total synthesis of (±)-liphagal.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Sora Yotsui
- Molecular aptamer beacon-based dual-mode exponential isothermal amplification for microRNA detection Tháng 7 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00962F, PaperYu Han, Xuefeng Bian, xiao wang, Jiaying Chen, Liu Han, Xin SunDue to the limiting factors associated with microRNAs (miRNAs), including their low abundance, short sequence length, and high family sequence homology, the gold standard for miRNA detection does not meet...The content of this RSS Feed (c) The […]Yu Han
- Stereoinversion in Pd-Catalyzed Allylic Substitution Induced by Modification of Olefinic Moiety in Chiral Phosphine-Acrylamide Ligands Tháng 7 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01034A, PaperKohei Watanabe, Yuto Toba, Shimpei Mita, Yusuke Kanda, Toru Yagi, Kento Kanauchi, Manami Kumada, Yasushi Yoshida, Yoshio Kasashima, Ryo TAKITA, Masami Sakamoto, Takashi MinoWe synthesized a series of phosphine-acrylamide chiral compounds 4 from chiral aminophosphine (S)-5 with various acyl chlorides and demonstrated that they can be used as […]Kohei Watanabe
- Lys-CQD Catalyzed Synthesis of Thiourea, Amide, and Formamide Compounds Using Renewable and Competitive Feedstocks Tháng 7 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00772K, PaperMorteza Hasani, Hamid Reza Kalhor, Masumeh Salehi, Fatemeh RahgozarThe use of renewable and cheap precursors in chemical synthesis is highly beneficial, yet challenging due to their inert chemistry and the need for complex catalysts to enhance their reactivity....The content of this RSS Feed (c) The Royal Society of […]Morteza Hasani
- Revisiting Mayr's reactivity database: expansion, sensitivity analysis, and uncertainty quantification Tháng 7 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00686D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Moritz K.-E. Wolff, Armin R. Ofial, Jonny ProppeAlgorithmic analyses of Mayr's reactivity database reveal best-practice guidelines for future data set design.To cite this article before page numbers are assigned, use the DOI form […]Moritz K.-E. Wolff
- Recent Advances in Three-Component Synthesis of Difluorinated Compounds Tháng 7 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01027F, Review ArticleZhan-Yong Wang, Ziyan Zhang, Weiyi Chen, Yang Liu, aili Sun, Ran XiaThe three-component reaction offers a convenient method for synthesizing difluorinated compounds. In this review, we classify and discuss synthetic methodologies over the past decade (2014–2024) into three categories: (a) Radical...The content of this RSS Feed (c) […]Zhan-Yong Wang
- N2-selective cross-couplings of tetrazoles with indoles Tháng 7 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00914F, CommunicationHui Zhang, Lifang Tian, Qinying Li, Hanwen Zheng, Yuting Dai, Jia-Wei Li, Guang-Lu Liu, Li-Li Zhu, Yahui WangA method for the N2-selective cross-coupling of tetrazoles with indoles is reported. The in situ-generated N2-iodotetrazole intermediates are found to be critical for both activating indoles and achieving N2-selectivity. Upon...The content […]Hui Zhang
- One-pot Synthesis of Sulfonyl 3,6-Diarylpyridazines via Tandem Condensation of α-Sulfonyl Ketones with Methyl Ketones Tháng 7 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01051A, PaperMeng-Yang Chang, Ou Chen-YoThe tandem condensation of α-sulfonyl ketones and methyl ketones produces diverse sulfonyl pyridazines in a yield of 70%-84% by one-pot Riley oxidation, Knovenagel condensation, and sequential dehydrative imine formation.The content of this RSS Feed (c) The Royal Society of ChemistryMeng-Yang Chang
- Synthesis of thiazolo[4,5-d]pyrimidine derivatives based on purine via solid-phase synthesis Tháng 7 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00963D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jimin Moon, Hyojin Lee, Jungtae Kim, Shuanghui Hua, GeonHo Yoon, Hyeokjin Lee, Sugyeong Seo, Yoojin Joo, Heong-Seop Yim, Taeho LeePurine derivatives with three points of diversity were synthesized via solid-phase synthesis through free […]Jimin Moon
- 2-Isocyanoanilines and their mono-Boc-protected derivatives Tháng 7 14, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00677E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adrian Saura-Sanmartin, Carmen Lopez-Leonardo, Mateo AlajarinAmongst the variety of synthetically useful isocyanides, 2-isocyanoanilines have been scarcely reported in the chemical literature, despite the rich chemistry that expectedly could derive from the reactivities […]Adrian Saura-Sanmartin
- Synthesis and biological activity of neopeltolide and analogs Tháng 7 13, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00931F, Review ArticleHua Cheng, Qiufei Hou, Dayong Peng, Dawei wangNeopeltolide, a macrolide natural product of marine origin, was initially isolated from a deep-sea sponge belonging to the Neopeltidae family. This compound has garnered significant attention due to its intriguing...The content of this RSS Feed (c) The Royal Society of […]Hua Cheng
- Click-like ortho-quinone methide trapping using rare 3-methylene isochromanones for a series of multifunctional pseudo-natural products Tháng 7 13, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00815H, PaperYi Wang, Dan Li, Hongping Long, Furong Liu, Guitao Bai, Kangping Xu, Xia Yu3-Methylene isochromanones, chemically challenging to access, are achieved via a novel click-like o-QM platform utilizing fermentation-accessible HOI as a reactive linchpin, enabling versatile access to diverse bioactive analogs.To cite this article before page numbers are […]Yi Wang
- Computational insights into the origins of regio- and enantioselectivities in palladium-catalyzed allylic substitution reactions Tháng 7 13, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00707K, Review ArticleHongli Wu, Deng Pan, Xueyuan Yan, Genping HuangThe recent advances on the computational studies of the palladium-catalyzed allylic substitution reactions have been summarized, with the focus on the selectivity-determining nucleophilic attack transition state models.To cite this article before page numbers are assigned, use the DOI form of […]Hongli Wu
- Catalyst-Free Aroylation of Maleimides through Csp2-H Functionalization with Aldehydes and Benzyl phenyl sulfides Tháng 7 11, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00692A, PaperElmira Taheri, Farnaz JafarpourAroyl maleimides and their derivatives have potential applications as inhibitors, fluorophores, antibiotics, and anticonvulsants. The Friedel-Crafts method, as the renowned aroylation method of arenes and heteroarenes, is tedious and suffers...The content of this RSS Feed (c) The Royal Society of ChemistryElmira Taheri
- Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C–H activation: development of synthetic TLX agonists Tháng 7 10, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00672D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lingaiah Maram, Puhan Zhao, Thomas Koelblen, Lamees Hegazy, Thomas P. Burris, Bahaa ElgendyWe report an efficient iodine-promoted oxidative cross-coupling for synthesizing (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-ones as potential TLX agonists.To cite this article before page numbers are […]Lingaiah Maram
- Palladium-catalyzed reductive cyclization of ortho-vinyl benzoic acids to access 1-indanones Tháng 7 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00860C, PaperZirun Wang, Chenglong Li, Bin Zheng, Qihang Tan, Qiang Wu, Long Liu, Jacek E. Nycz, Tianzeng Huang, Tieqiao ChenFrom ortho-vinyl benzoic acids, this reaction underwent a tandem process of intramolecular cyclization and hydrogenation, yielding diverse 1-indanones with valuable functional groups in good to high yields.To cite this article […]Zirun Wang
- Recent advances in the synthesis of multiple helicenes Tháng 7 17, 2025
