RSC – Org. Biomol. Chem. latest articles- Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions Tháng 6 8, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00687F, PaperChibisree Elanchezhian, Nandana Mohan, Mrinal Kanti Das, Saikat ChaudhuriA homogeneous DABCO(TfOH)₂-catalyzed protocol has been developed for the regioselective alkylation of 2-oxindoles using secondary alcohols under mild conditions. The transformation proceeds efficiently in HFIP through effective activation of the...The content of this RSS Feed (c) The Royal Society of […]Chibisree Elanchezhian
- Metalloradical and photoredox manifolds in manganese photocatalysis Tháng 6 8, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00695G, Review ArticleMaulik Pethani, Yash Dhaduk, Shivam Vispute, Anilkumar Kommoju, Shreeya Dave, Arpan Patel, Kishor Padala, Togati NaveenVisible-light-driven manganese catalysis has emerged as a powerful and sustainable alternative to noble-metal-based photoredox systems. Owing to its abundance on Earth, low toxicity, and rich redox flexibility, manganese enables a...The content of […]Maulik Pethani
- Palladium-catalyzed Synthesis of S-Aryl Thiocarbamate via Desulfurative C-S Cross-coupling Reaction of Dithiocarbamates Tháng 6 8, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00331A, PaperRahul Mondal, Manas Mondal, Amit SahaA new protocol for synthesizing S-aryl thiocarbamate has been demonstrated here by the desulfurative C-S cross coupling of dithiocarbamate esters with arylsilanes in presence of Pd(II)-catalyst and Cu(II)-oxidant. A series...The content of this RSS Feed (c) The Royal Society of ChemistryRahul Mondal
- Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks Tháng 6 8, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00839A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Victoria Sodré, Goran M.M. Rashid, Boriana V. Yotzova, Timothy D.H. BuggPyridines are found in many pharmaceuticals and agrochemicals, but are synthesised from fossil fuel conversion. 2,4- and 2,5-Pyridinedicarboxylic acids have been reported as […]Victoria Sodré
- Synthesis of aza-β-lactams via B(C6F5)3-catalyzed Wolff rearrangement/[2+2] cascade cyclization of α-diazoketones with diazenes Tháng 6 7, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00455E, PaperWeihong Song, Yu-xiao Ye, Jing-dong Wu, Jun-Jie Li, Xiao-Mei Jiang, Rong-bin Zhao, Wei-Guo Yu, Ziwei XiangThe development of efficient, metal-free routes to aza-β-lactams is a significant pursuit in synthetic and medicinal chemistry. Herein, we report a novel, one-pot cascade strategy for the synthesis of aza-β-lactams...The content of this […]Weihong Song
- Distinct Reactivity of Aromatic and Aliphatic Thiols for the Efficient Synthesis of Chromeno[2,3-d]pyrimidine and Chromeno[4,3-b]chromene Derivatives: Mechanistic Investigations and Reaction Scope Tháng 6 7, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00585C, CommunicationSuman Sourabh, Yogesh Bhaskar Singh Tanwer, Raj Rani, Sabyasachi Bhunia, Sanchari Pal, Debjit DasIn this study, an efficient and convenient three/two-component cyclization protocol is presented for the development of synthetically valuable chromeno[2,3‐d]pyrimidine derivatives via pTSA-catalyzed reaction of substituted salicylaldehyde, 1,3-dimethylbarbituric acid, and both...The content of this RSS Feed […]Suman Sourabh
- Synthesis of meta-substituted phenols and 1-estradiol conjugated analogues of suberoylanilide hydroxamic acid (SAHA) Tháng 6 7, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00599C, PaperChanoknun Boonyaratsewee, Kitiya Rujimongkon, Wannarasmi Ketchart, Somsak Pianwanit, Yongsak Sritana-AnantEstradiol conjugated drugs are one of the prime targets toward developing into new treatments of hormone-responsive types of cancer. Due to the overexpression of estrogen receptor (ER) in breast cancer...The content of this RSS Feed (c) The Royal Society […]Chanoknun Boonyaratsewee
- Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids Tháng 6 5, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00643D, PaperFeng Chen, Zhiqin Zhang, Jianwei Wang, Jiaxi Xu, Hongguang Du, Ning ChenA visible-light-driven, three-component coupling for the synthesis of N-aryl amino acids and unnatural peptides is described, which proceeds under mild, catalyst-and photocatalyst-free conditions-even under natural sunlight. Glyoxylates, anilines, and 4-alkyl...The content of this RSS Feed (c) The […]Feng Chen
- Metal-Ligand Cooperative Ni(II) Catalysis for One-Pot Access of Biologically Relevant Quinolines and Their Transfer Hydrogenation Tháng 6 5, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00303F, PaperVirendra Kumar Chaudhary, Keshav Sharma, Prashant Kukreti, Sain Singh, Kaushik GhoshHerein, we present a square planar Ni(II) cooperative catalyst affixed by azo- and amido-based ligand that has been effectively employed for accessing highly substituted quinolines utilizing 2-aminoaryl alcohols with 2°-alcohols....The content of this RSS Feed (c) The Royal […]Virendra Kumar Chaudhary
- Cu-catalyzed oxidative coupling of alkylarenes with tertiary C(sp3)–H bonds via C–H activation Tháng 6 4, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00723F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gang Hong, Pradip D. Nahide, Wahiduddin G. Patel, Marisa C. KozlowskiEfficient Cu-catalyzed CDC of alkylarenes with tertiary C(sp3)–H Bonds via C–H activation.To cite this article before page numbers are assigned, use the DOI […]Gang Hong
- The Sulfo-Click Reaction: Expanding the Toolbox for Bioconjugation and Medicinal Chemistry Tháng 6 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00609D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Michael Smietana, Romain Amador, Guillaume ClavéThe sulfo-click reaction, which relies on the chemoselective coupling of sulfonyl azides with thioacids to yield Nacylsulfonamides, has emerged as a powerful and versatile transformation in synthetic […]Michael Smietana
- Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes Tháng 6 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00637J, PaperRambabu Kandukuri, Madhu Inapanuri, Nagaraju Naddi, Hari Prasad KokatlaA transition-metal-free rongalite-mediated strategy has been developed for the geminal difunctionalization of fluorene derivatives, enabling the efficient synthesis of (9-methyl-9H-fluoren-9-yl)methanols derivatives. In this transformation, rongalite plays a dual role as...The content of this RSS Feed (c) The Royal Society of […]Rambabu Kandukuri
- Bioinspired direct diversification of Pinus densiflora resin via an oxa-Diels-Alder reaction and its anti-neuroinflammatory effects in BV2 microglial cells Tháng 6 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00452K, PaperVan-Hieu Mai, Seri Choi, Yunhui Che, Gi-Hyeon Seong, Jae S Park, Jin-Pyo An, Yun-Sil Lee, Won-Keun OhThe resin of Pinus densiflora (Pine resin) serves as a natural reservoir rich in abietane-type diterpenoids, a structurally diverse class of secondary metabolites with notable pharmacological potential. To enhance the...The content of […]Van-Hieu Mai
- Synthesis of Enaminones Enabled by Potassium Persulfate Oxidative N-Dealkylation and Addition to Ynones Tháng 6 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00759G, PaperYong Xiao, Li-Gang Kou, Bin-Xuan Zou, Qiong Jia, Yong-Qiang WangThe development of efficient and practical N-dealkylation methods stands as a long-sought goal in synthetic chemistry. Herein, we developed a convenient N-dealkylation reaction of tertiary amines enabled by the oxidation...The content of this RSS Feed (c) The Royal Society […]Yong Xiao
- Sortase A-Mediated Hydrazinolysis Generates Homogeneous N-Terminal GL Proteins for OaAEP1-Catalyzed Bioconjugation Tháng 6 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00719H, PaperJunjiang Li, Tingting Cui, Jian Sun, Yi-Ming LiOaAEP1-mediated ligation provides an effective platform for site-specific protein modification, but it needs to obtain homogeneous N-terminal Gly-Leu (GL) protein substrates. Here, we describe a Sortase A-mediated hydrazinolysis approach for...The content of this RSS Feed (c) The Royal Society of ChemistryJunjiang Li
- A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media Tháng 6 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00384B, PaperMonika Monika, Prashant Kumar, Brajendra Kumar SinghA sustainable and regioselective protocol for mono-halogenation of 3-arylquinoxalin-2(1H)-ones has been developed, utilizing 1,3-dihalo-5,5-dimethylhydantoin derivatives as halogen sources. A dual catalytic system combining Pd(OAc)₂ and water-soluble Eosin Y was employed...The content of this RSS Feed (c) The Royal Society of ChemistryMonika Monika
- Direct C4-H Amination of Pyridines and Quinolines under Benign Conditions Tháng 6 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00669H, PaperTong Han, Fenlian Xu, Xinqiao Nie, Dong WangExisting methods for the para-C-H amination of pyridines and quinolines are scarce and rely exclusively on indirect approaches. These typically involve initial installation of an amine surrogate or an aryl...The content of this RSS Feed (c) The Royal Society of ChemistryTong Han
- HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes Tháng 6 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00743K, CommunicationXiaochen Ji, Huawen Huang, Yixi ZhangCross-dehydrogenative coupling (CDC) reactions offer high atom economy and simple synthetic routes, and are widely employed for the coupling of heterocyclic rings. Herein, we report a transition-metal-free HBr-catalyzed aerobic CDC...The content of this RSS Feed (c) The Royal Society of ChemistryXiaochen Ji
- Temperature-Directed in situ Generation of Fluorobenzyl Radicals: Utilization for the Complete Fluorobenzylation of Tri-, and Tetramethylbenzenes Tháng 6 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5OB01908G, PaperDharmveer Bhedi, Ramalingam ThirumoorthiOrganofluorine compounds have been broadly employed in the fields of pharmaceuticals, agrochemicals, and materials. Concurrently, the well-known star-shaped molecules, 1,3,5-trifunctionalized-2,4,6-trialkylbenzene, are of interest in supramolecular chemistry. For the first time,...The content of this RSS Feed (c) The Royal Society of ChemistryDharmveer Bhedi
- A Hydrido-Alkynyl-Prins Cyclization Using Isopropanol as Hydride Donor: Discovery, Scope and Mechanistic Study Tháng 6 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00688D, PaperBeeraiah Baire, Ramesh Gollachinnamola, Surabhi MishraThe Alkynyl-Prins cyclization is a very important strategy in organic synthesis for the construction of cyclic frameworks and natural products, via vinyl carbocation intermediate under acid catalysis. Surprisingly, the alternate...The content of this RSS Feed (c) The Royal Society of ChemistryBeeraiah Baire
- Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions Tháng 6 8, 2026
