RSC – Org. Biomol. Chem. latest articles- Diastereoselective oxidative cyclization of 1,4-dienes for the synthesis of oxetanes Tháng 3 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00220J, CommunicationShengxin Wang, Yanhua Zhang, Chao Wang, Lili ZongIn this paper, an osmium catalyzed oxidative cyclization of 1,4-dienes is reported. The reaction undergoes exo,exo-type cyclization, with oxetanes obtained for the first time as oxidative cyclization products. Catalytic amount...The content of this RSS Feed (c) The Royal Society of ChemistryShengxin Wang
- RhIII-Catalyzed C–H Heteroarylation and C–N Cleavage: Direct Access to C2-heteroarylated (NH)-indoles Tháng 3 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00059B, PaperHuaiwei Wang, Zhen-Ang Liu, Xiao Guan, Xiao-Wen Su, Yu-Tong DongHerein, we disclosed a Cp*Rh(III)-catalyzed C2-heteroarylation of indoles bearing an N 2,6 difluoroaryl amide auxiliary with heterocyclic boronates, followed by auxiliary cleavage, offering an efficient route to biheteroaryl derivatives containing...The content of this RSS Feed (c) The Royal Society […]Huaiwei Wang
- Cationic [1,2]-Aryl shift in the design of poly(hetero)aromatic systems: from structure to functional materials Tháng 3 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00064A, Review ArticleValerii Z. Shirinian, Igor S. Mekeda, Roman Yu. BalakhonovMolecular rearrangements occupy an important place in organic chemistry because they make it possible to significantly modify organic molecules in a single step to obtain new compounds with desirable applied...The content of this RSS Feed (c) The Royal Society […]Valerii Z. Shirinian
- Efficient Synthesis of 4-Pyridone-3-carboxylic Acids via the Reaction of Enaminated Diketonates with Primary Amines Tháng 3 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00087H, PaperAnastasia Andreevna Tereshkina, viktoria Vladimirovna Viktorova, Dmitrii L'vovich Obydennov, Vyacheslav SosnovskikhA novel approach has been described for the synthesis of 4-pyridones based on enaminated diketonates, which is a green alternative to the widespread transformation of 4-pyrones with amines in organic...The content of this RSS Feed (c) The Royal […]Anastasia Andreevna Tereshkina
- Divergent Assembly of Fused Polycyclic Scaffolds from Iodotriazole-Tethered Benzaldehydes Tháng 3 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00280C, PaperAnfisa L. Shosheva, Roman S. Tatevosian, Gennadij Latyshev, Yury Kotovshchikov, Nikolai Lukashev, Irina P Beletskaya5-Iodo-1,2,3-triazoles tethered to a formyl group via an ortho-phenylene linker have been shown to be versatile precursors to a plethora of fused heterocyclic systems. A high reactivity of the aldehyde...The content of this RSS […]Anfisa L. Shosheva
- Efficient One-Step Synthesis of 3-Nitroflavones via Cascade Nitration-Cyclization Tháng 3 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00238B, CommunicationYilin Yang, Chukai Shao, Ruirui Hua, Rui Tian, Ziang Wang, Hongquan Yin, Houhua Zhu, Fu-Xue ChenA mild and regioselective nitration–cyclization of alkynyl aryl ketones has been developed to access 3-nitroflavones promoted by Zn(OTf)2. Tandem nitration and intramolecular cyclization is achieved using 68% HNO3 under room-temperature...The content of this […]Yilin Yang
- Correction: Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition Tháng 3 11, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB90028C, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Astha M. Dwivedi, Raymond J. Butcher, Ashutosh V. BedekarTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Astha M. Dwivedi
- Diazo Retention Transformations of Aryldiazonium Salts Towards Nitrogen-Rich Heterocycles Tháng 3 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01812A, Review ArticleMani Ramanathan, Ziad Moussa, Rama Krishna PeddintiDeveloping novel synthetic methodologies to access fused nitrogen heterocycles is an active research area of organic chemistry for several decades. Due to their valuable contribution of N-fused heterocycles in organic...The content of this RSS Feed (c) The Royal Society of ChemistryMani Ramanathan
- Annulation of aliphatic nitro compounds with β-styryl sulfonium salts toward the synthesis of isoxazoline N-oxides Tháng 3 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00176A, PaperPavel Ushakov, Stepan N. Chichulin, Alexey Yu. Sukhorukov, Andrey TabolinVinyl sulfonium salts proved to be convenient building blocks in modern organic synthesis due to the wide variety of their reactivities. In this study, we expand the spectrum of possible...The content of this RSS Feed (c) The Royal Society […]Pavel Ushakov
- Koser’s Reagent Promoted Synthesis of Substituted Isoxazoles and their Photophysical Properties Tháng 3 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB02000J, PaperRajnish Budhwan, Pooja Dahiya, Nikunj Singh, Shivom Chauhan, Rama Krishna PeddintiA practical and transition-metal-free strategy for the synthesis of structurally diverse isoxazole architectures has been developed. The protocol employs Koser’s reagent (hydroxy(tosyloxy)iodobenzene, PhI(OH)OTs), to promote the oxidative cyclization of readily...The content of this RSS Feed (c) The Royal […]Rajnish Budhwan
- Organocatalytic regio-and stereoselective synthesis of chiral tetrasubstituted α-amino allenoates by γ-additions of β,γ-alkynylα-imino esters with pyrazolones Tháng 3 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00191B, CommunicationZhenghua Zhou, Yongqiang Xu, Wenkai Li, Jingping Qu, Yuhan Zhou, Baomin WangHerein, we report a bis-dihydroquinine-catalyzed asymmetric nucleophilic addition of pyrazolones to β,γ-alkynyl-α-imino esters. This method enables the efficient synthesis of allenylpyrazolone derivatives featuring adjacent quaternary stereocenters and axially chiral tetrasubstituted...The content of this RSS Feed (c) The […]Zhenghua Zhou
- Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl-3-chloropropenals with Tetrahydro-β-carboline: A Method for the Synthesis of Indolizino[8,7-b]indole Compounds Tháng 3 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00015K, CommunicationKai rong Chen, Miao Yang, Shuang Chen, Yanchuan Gong, Junnan Xu, Mei xiang Ye, Jie Zhang, Liang GuoAbstract: This paper reports a novel base-promoted intermolecular tandem cyclization reaction between 3-aryl-3-chloropropenals and tetrahydro-β-carboline. This reaction provides a simple and practical method for the synthesis of indolizino[8,7-b]indoles, yielding a...The content […]Kai rong Chen
- 3H-Phenothiazin-3-one: A Photocatalyst for the Mild Oxidation of Boronic Acids Under Green LED Irradiation Tháng 3 9, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00133E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Constantinos T. Constantinou , Petros L Gkizis, Dragos F Flesariu, Stamatis K. Serviou, Georgia A. Zissimou, Panayiotis A. Koutentis, Christoforos G Kokotos3H-Phenothiazin-3-one is a small organic molecule with established biological properties, yet its […]Constantinos T. Constantinou
- Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors Tháng 3 9, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01897H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Arun K. Ghosh, Amlan Bhattacharjee, Uttara Jayashankar, Sydney N. Bogan, Andrew D. MesecarDiastereoselective Ugi-multicomponent reactions (Ugi-MCR) are investigated. These reactions provided bis-amides up to 91 : 9 dr and moderate to good yields.To cite this […]Arun K. Ghosh
- Decarboxylative Giese additions through electron donor–acceptor complexes under transition metal-free conditions Tháng 3 9, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB02007G, PaperHao Tian, Cai-Ling Xu, Yi-Fang Li, Yong-Heng Wang, Gen-Long Jiao, Hao Gao, Rong-Rong HeHerein, we describe a metal-free Giese addition reaction method based on RAEs/HEH complexes under thermal conditions. The excellent tolerance to water and oxygen makes this method highly suitable for late-stage modification.To cite this article before […]Hao Tian
- Peptide-directed solid-phase reductive amination Tháng 3 9, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00034G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Grigoropoulou, Dimitrios Tolis, Evrydiki Nierri, Angeliki Georgia Mandrapylia, Dimitrios Gatos, Kleomenis Barlos, Spyridon MourtasSolid-phase reductive amination of C-terminal peptide α-amino aldehydes enables amide-to-Ψ[CH2–NH] replacement with controllable racemization.To cite this article before page […]Maria Grigoropoulou
- Palladium-catalyzed 1,4-Migration for the Regioselective C-H Bond Functionalization at C2-Position of 3-Arylthiophenes Tháng 3 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00099A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bo Lan, Norman Le Floch, Henri DoucetThe regioselective functionalization of the C-H bond at the C2-position of 3-substituted thiophenes is challenging, as both thienyl a-positions may be reactive, generally affording mixtures of C2-, […]Bo Lan
- Environmentally benign esterification and disproportionation using activation of acid anhydrides by molecular sieves 3A Tháng 3 6, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00088F, PaperNana Hatayama, Yuna Yoshioka, Nagatoshi NishiwakiThe carbonyl group of an acid anhydride was activated by molecular sieves 3A, enabling nucleophilic substitution with an O-nucleophile under mild conditions even in the absence of any catalyst and without the formation of detectable byproducts.To cite this article before page numbers are […]Nana Hatayama
- Access to S,C-sulfonium ylides from iodonium ylides via iron catalysis Tháng 3 5, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00230G, CommunicationWanqi Hu, Xingyu Chen, Xiaowei WuIron-catalyzed transylidation enables a mild, sustainable route to S,C-sulfonium ylides from sulfides and iodonium ylides. This efficient, broadly applicable method offers a practical method for constructing valuable sulfur-based building blocks.To cite this article before page numbers are assigned, use the DOI form of […]Wanqi Hu
- Synthesis of Tri-substituted, Aliphatic and 13C-Labelled α,β-Unsaturated Carboxylic Acids via Wittig CO2 Utilisation Reactions Tháng 3 5, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00221H, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel E Lynch, Amy Lowry, Gerard P. McGlacken, Peter ByrnePhosphonium carboxylate ylides are formed through CO2 activation by phosphonium ylides. These can undergo Wittig reactions with carbonyl compounds, thereby enabling formation of both […]Rachel E Lynch
- Diastereoselective oxidative cyclization of 1,4-dienes for the synthesis of oxetanes Tháng 3 11, 2026
