RSC – RSC Med. Chem. latest articles- Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands June 28, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00312E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Arun K. Ghosh, Ashish Sharma, Satyanarayana Iddum, Sydney N. Bogan, Uttara Jayashankar, Emma K. Lendy, Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D. MesecarA series of potent SARS-CoV-2 Mpro inhibitors is designed, […]Arun K. Ghosh
- Inhibition effects and binding behavior of alginate oligosaccharides on tyrosinase and elastase: multi-spectroscopic approaches and zebrafish evaluation June 28, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00183A, Research ArticleHangen Li, Shuyi Liang, Yuanyi Cen, Yan Liang, Xuetao Xu(1) AOSs were inhibitors on tyrosinase and elastase. Multi-spectroscopic and docking approaches revealed inhibition interaction of AOSs on tyrosinase and elastase. (2) AOSs displayed the ability of melanin inhibition and ROS clearance.To cite this article before page numbers […]Hangen Li
- Ring-Opening Simplification of Thiazolyl-Pyrazoline-Triazole Hybrids: Synthesis, SAR and Antifolate Mechanism Against Leishmania major June 26, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00382F, Research ArticleEsraa A Abdelsalam, Wagdy M. Eldehna, Radwan El-Haggar, Sherif Hammad, Nicolas MASURIER, Tamer M Ibrahim, Kikuko Amagase, Sherry N Nasralla, Hatem A. Abdel-Aziz, Adnan BekhitLeishmaniasis, a neglected tropical disease with a severely limited and toxicity-prone therapeutic arsenal, urgently demands structurally innovative drug candidates. Capitalizing on the well-established […]Esraa A Abdelsalam
- Combining β2-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease June 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00250A, Research ArticleAlice Wang, Thomas Curel, Sylvie Claeysen, Valentin Travers-Lesage, Marie Elodie Hélène Cadot, Audrey Davis, Jana Sopkova de Oliveira Santos, Fabrice Modeste, Xavier Brazzolotto, Florian Nachon, Patrick Dallemagne, Marc Since, Christophe RochaisAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder for which the current treatments remain largely symptomatic. Pleiotropic […]Alice Wang
- From dual norepinephrine-dopamine reuptake inhibition to selective dopamine reuptake inhibitors: a case of aromatically substituted N,2-cyclopentylamines June 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00112B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Majlen A. Dilweg, Willem Jespers, Ameya S Kasture, Rongfang Liu, Tamara A. M. Mocking, Jelle G Van Der Ploeg, M M Baselier, Gerard Van Westen, Thomas Hummel, Sonja Sucic, Adriaan P. IJzerman, […]Majlen A. Dilweg
- Drug Repurposing of Fluvastatin as a DP2 Antagonist: An Ensemble Learning Strategy with In Vitro Cellular Functional Validation June 23, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00403B, Research ArticleGuoHui Wei, Zhuo Sun, Yuanxu Gao, Jia Heng, Wenyang Lu, Zixing ZouWe present a framework to repurpose FDA-approved drugs as DP2 antagonists for asthma, using a two-stage strategy. First, we train and evaluate eight models—five machine learning algorithms and three graph...The content of this RSS Feed (c) […]GuoHui Wei
- Discovery of Novel SIRT3 Inhibitors with MLLr Leukemia Inhibitory Potency June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00249H, Research ArticleShaopeng Chen, Xinyang Wei, Honggang Li, Jiangying Cao, lei zhangSIRT3 has emerged as a therapeutic target for the treatment of leukemia. Based on our previously identified lead compound, structural modification was performed in the current study. A total of...The content of this RSS Feed (c) The Royal […]Shaopeng Chen
- Discovery of Novel Indazole Derivatives with Antineuroinflammatory Activity June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00270F, Research ArticleQing qing Zhang, Xixi Hou, Xuanwei Zhang, Yimian Wang, Yaquan Cao, Lan Wang, Longfei MaoThis study focuses on the critical role of microglia-mediated neuroinflammation in various neurological disorders. Utilizing the indazole heterocycle-a scaffold known for its structural plasticity and multi-target potential-as the core structure,...The content of this […]Qing qing Zhang
- Exploring the Antimycobacterial Profile of N-Alkyl Imidazoles June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00418K, Research ArticleAlejandro I. Recio-Balsells, Gabriel Di Gresia, Marcelo Luciano Merli, Julia Alejandra Cricco, Hector R. Morbidoni, Guillermo R LabadieThe emergence of drug-resistant Mycobacterium tuberculosis strains and non-tuberculous mycobacteria (NTM) species such as Mycobacterium abscessus, highlights the urgent need for new chemotypes with broad-spectrum antimycobacterial activity. In this study,...The […]Alejandro I. Recio-Balsells
- Synthesis and Bioevaluation of Substituted 2,11-dihydroimidazo[1′,5′:1,2]pyrido-[3,4-b]indoles as antiplasmodial and antiproliferative agents June 22, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00085A, Research ArticleAdilakshmi Vutla, Akash Pandey, Amanullah Sayeed, Richa Shukla, Ashan Manhas, Niti Kumar, Sanjeev Meena, Dipak Datta, Sanjay BatraThe synthesis and bioevaluation of a new series of substituted 2,11-dihydroimidazo[1’,5’:1,2]pyrido-[3.4-b]indoles as antiplasmodial and antiproliferative agents are described. Several compounds (16aaf, 16abf, 16acf, 16adq, 16aeo, and 16afe ) exhibited significant...The […]Adilakshmi Vutla
- Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands June 28, 2026
