RSC – RSC Med. Chem. latest articles- Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects October 9, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00650C, Review ArticleChao Zhang, Jialin Guo, Zixiao Liu, Xuhui Huang, Shiqi Dong, Chun Hu, Junhai XiaoCME requires multiple proteins that sequentially enclose liganded receptors into a fully formed endosome. This review explores the current knowledge on CME inhibitors to different targets.To cite this article before page numbers are assigned, […]Chao Zhang
- Discovery of an Internal Alkyne Warhead Scaffold for Irreversible hTG2 Inhibition October 8, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00777A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lavleen Mader, Namita Maunick, Jessica Borean, Jeffrey W KeillorHuman tissue transglutaminase (hTG2) is a multifunctional enzyme with both protein cross-linking and G-protein activity. Dysregulation of these functions has been implicated in diseases […]Lavleen Mader
- Bacteriophage-mediated Antibacterial and Photodynamic Therapies October 7, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00669D, Review ArticleRui Yu, Guo-Bo Li, Bengui Ye, Jong Seung Kim, Xuechuan Hong, Yuling Xiao, Xiaodong ZengAntimicrobial resistance threatens global health, with multidrug-resistant pathogens causing millions of deaths annually. Conventional antibiotics face limitations due to bacterial biofilms, resistance mechanisms, and host toxicity. Bacteriophages, due to their...The content of this […]Rui Yu
- The Versatile Synthesis and Biological Evaluation of All-Alkyl Biscationic Quaternary Phosphonium Compounds: Atom-Economical and Potent Disinfectants October 7, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00660K, Research ArticleDiana McDonough, Elise L Bezold, Kevin P.C. Minbiole, William WuestGiven the growing resistance to traditional quaternary ammonium compounds (QACs) - long used as primary disinfectants - there is an urgent need for structurally distinct alternatives to effectively combat infectious...The content of this RSS Feed (c) The Royal […]Diana McDonough
- Discovery of indole- and quinolone-based inhibitors of the mTOR/Akt/Pi3K pathway for the potential treatment of autism and certain types of cancer October 7, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00641D, Research ArticleAhmad E Elshahary, Hesham Safwan, Ahmad M. Abdelwaly, Reem K. Arafa, Mohamed HelalMammalian target of rapamycin (mTOR) is a serine/threonine kinase that belongs to the PI3K-related protein kinase family. It is an integral part of two functionally distinct protein complexes: mTOR complex...The content of this RSS Feed […]Ahmad E Elshahary
- Analysis of two screens reveals a correlation between antiamoebic and anti-tubulin activities of phenothiazine and triphenylethylene derivatives October 6, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00715A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Oleg Mediannikov, Philipp O. TsvetkovFor phenothiazine and triphenylethylene derivatives—including triflupromazine and tamoxifen—modulation of heat-induced tubulin polymerization strongly correlates with antiamoebic activity.To cite this article before page numbers are assigned, use the DOI […]Oleg Mediannikov
- Correction: Emerging opportunities in the rewiring of biology through proximity inducing small molecules October 6, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD90040A, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael M. HannTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryMichael M. Hann
- Harnessing Photodynamic Therapy for Programmed Cell Death: The Central Role and Contributions of Metal Complexes as Next Generation Photosensitizers October 6, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00630A, Review ArticleSreejani Ghosh, Rinku Chakrabarty, Priyankar PairaA fundamental biological mechanism, programmed cell death (PCD), is essential for tissue homeostasis, immunological control, and development. It’s dysregulation is a characteristic of many diseases in multicellular organisms, including cancer,...The content of this RSS Feed (c) The Royal Society of ChemistrySreejani Ghosh
- Structural Insights into the Activity of Carbapenemases: Understanding the Mechanism of Action of Current Inhibitors and Informing the Design of New Carbapenem Adjuvants October 6, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00732A, Review ArticleTahlia Hatzisarantinos, Elissar Mansour, Jonathan Du, Mohamed Fares, David Hibbs, Paul GroundwaterAntimicrobial resistance challenges the effectiveness of carbapenem antibiotics as last-line therapy, due to the production of both serine and metallo-β-lactamase enzymes. β-Lactamase inhibitors currently available on the market include clavulanic...The content of this RSS Feed (c) […]Tahlia Hatzisarantinos
- Cyclodextrin derivatives that exhibit Enterococcus-specific antibacterial properties through the accumulation of guanidino and indole groups October 2, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00525F, Research ArticleAtsushi Miyagawa, Tetsuro Higashino, Hisato Kato, Kazufumi Masuda, Hatsuo YamamuraThe assembly of guanidino and indole groups induces Enterococcus-specific antibacterial properties incyclodextrin.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryAtsushi Miyagawa
- Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects October 9, 2025
