RSC Medicinal Chemistry

RSC – RSC Med. Chem. latest articles

• Design, Synthesis and Evaluation of Fluorescent Dihydropyridine-Dihydropyrimidinone Hybrids as Inducer of Cell-Cycle Arrest in Prostate Cancer Cell Line via Aurora Kinase interactions September 15, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00635J, Research ArticleVanessa Pereira de Souza, Izabela Gomes, Samuel J Santos, Carolyne B Braga, Aryel J Bezerra, Eric A Philot, Cíntia R Ramos, Simone Q Pantaleão, Luciane S. Da Silva, Ronaldo Pilli, Rui Manuel Reis, Renato J Oliveira, Dennis RussowskyThe fluorescent Dihydropyridine-Dihydropyrimidinone (DHP-DHPM) hybrids were easily synthesized through the […]
  Vanessa Pereira de Souza
• Development of novel Alpha 2B adrenergic receptor ligands by using a palladium catalyzed Buchwald Hartwig amination with a brominated benzodiazepine September 15, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00611B, Research Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maya Fernando, Alexander Vincent, Shaun Harrington, Mubaraq Toriola, Kayode Medubi, Michelle j Meyer, Daniel Webb, L. A. ArnoldSome benzodiazepines with excellent affinities to the gamma aminobutyric receptors have been reported to attenuate […]
  Maya Fernando
• Introduction to the themed collection on kinases September 14, 2025
  RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD90032H, EditorialMeizhong Jin, Hayley Binch, David E. Heppner, Philip JonesHayley Binch, David E. Heppner, Meizhong Jin and Philip Jones introduce the RSC Medicinal Chemistry themed collection on kinases.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]
  Meizhong Jin
• Design, Synthesis, and Biological Evaluation of Indazole-Based PLK4 Inhibitors September 11, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00654F, Research ArticleCunZheng Fan, nian liu, Ningyuan Hu, Minghui Tong, Xuan Shi, Han Wang, Wenqiang Sun, Zehui Qi, Haoyu Zhang, Yixiang sun, Zixuan Gao, Dongmei Zhao, Maosheng ChengPLK4 (Polo-like kinase 4), a member of the serine/threonine protein kinase family, serves as a central regulator of centriole duplication and plays […]
  CunZheng Fan
• Design, synthesis, and biological evaluation of 2-phenylthiazole CYP51 inhibitors September 10, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00535C, Research ArticleKejian Li, Guoqi Zhang, Wenzhan Hao, Jinming Liu, Yixiang sun, Zixuan Gao, Zirui Luo, Rui Liu, nian liu, Haoyu Zhang, Xudong Wu, Dongmei Zhao, Maosheng ChengFungal pathogens have emerged as one of the most significant threats to global public health. Invasive fungal infections, characterized by high morbidity […]
  Kejian Li
• Synthetic pancreatic lipase inhibitors in obesity treatment: Current updates on in-silico design, synthesis, bioactivity and SAR September 10, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00373C, Review ArticleUtkarsh A. Jagtap, Atish T PaulTaking a stand against obesity is an urgent priority, as it significantly impacts both the global economy and public health. Synthetic pancreatic lipase (PL) inhibitors represent one of the most...The content of this RSS Feed (c) The Royal Society of Chemistry
  Utkarsh A. Jagtap
• The Rise of Ultrashort Cationic β-Peptides as Promising Antimicrobial Therapeutics September 10, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00596E, Review ArticleHadiya Amin Kantroo, Itibaw Farooq, Zahoor Ahmad ParryAntimicrobial resistance (AMR) is a mounting global health crisis demanding novel, sustainable therapeutic strategies beyond traditional antibiotics. Ultra-short cationic β-peptides have emerged as a promising class of synthetic antimicrobial foldamers...The content of this RSS Feed (c) The Royal Society of […]
  Hadiya Amin Kantroo
• Design, Synthesis, and Structure–Activity Relationship Studies of 4-substituted Phenylpyrazolidinone Derivatives as Potent Ku70/80 Targeted DNA-PK Inhibitors September 9, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00263J, Research Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Narva Deshwar Kushwaha, Pamela VanderVere-Carozza, Tyler L. Vernon, Pamela L. Mendoza-Munoz, Jitender D. Gaddameedi, Karim Ben Ali Gacem, Joseph Engel, Jean-Baptiste Charbonnier, Navnath S. S Gavande, John TurchiThe Ku70-Ku80 (Ku) heterodimer complex […]
  Narva Deshwar Kushwaha
• Recent Advances in Structural Modifications of Natural Products for Anti-Leishmaniasis Therapy (2010-2024). September 8, 2025
  RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00534E, Review ArticleFu-Qun Sun, Yin-Sheng Quan, Qing-Kun Shen, Hong-Yan Guo, Xiu-Mei Yin, Zhe-Shan QuanLeishmaniasis represents a significant threat to global health as a neglected tropical disease. While therapeutic options exist, their high cost, safety concerns, and significant adverse effects necessitate the discovery of...The content of this RSS Feed (c) […]
  Fu-Qun Sun
• Polyphenolic compounds as protective agents against cisplatin-induced ototoxicity with molecular mechanisms and clinical potential September 8, 2025
  RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00426H, Review ArticleTong Wei, Jing Nie, Dongbo Wang, Huina Wu, Lijiao Guan, Jiyong WuGraphical abstract merges cisplatin ototoxicity pathways, polyphenol protection, chemo-synergy conflicts, and translational roadmap from preclinical to therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]
  Tong Wei