RSC – RSC Med. Chem. latest articles- Novel zerumbone-amide-triazole hybrids as potential NF-κB pathway inhibitors: design, synthesis, cytotoxicity evaluation, computational studies, and mechanistic insights March 26, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00148C, Research ArticleChinh The Pham, Thi Tham Pham, Lien Thi Vu, Nhung Thi Dao, Loan Thi Thuy Le, Khieu Thi Tam, Vu Tuan Kien, Cao Thanh Hải, Thanh Phuong Phan, T. T. Thao, Truong Xuan Vuong, Le Thi LienA series of fifteen novel zerumbone-amide-triazole hybrids 12a-i and 15a-f were […]Chinh The Pham
- Design, Synthesis, and Biological Evaluation of Quinoline Derivatives as Dual-target Inhibitors of Chitin Synthase and Glucosamine-6-Phosphate Synthase March 26, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5MD01001B, Research ArticleNan Wang, Lige Liu, Tao Liu, Hong Luo, Yan Long, Xinglong Yang, Youli Zhang, Qinggang JiTwo series of compounds were designed and synthesized based on a glycine methyl ester-quinoline core scaffold combined with a fragment containing nitrogen using either an isoxazole or a piperidine carboxamide...The content of […]Nan Wang
- D-Galactose-conjugated pyrimidine thioureas as potent antimicrobial agents: rapid green synthesis, structure-activity relationships and molecular modelling March 25, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00026F, Research ArticleNguyen Dinh Thanh, Vu Ngoc Toan, Ngo Hong Anh Thu, Nguyen Minh Tri, Duong Ngoc Toan, Hoang Thi Kim VanA series of D-galactose-conjugated pyrimidine-based thioureas 8a-l was efficiently synthesized using an environmentally benign ionic liquid-microwave protocol. Optimal conditions employing [BMIM][BF4] under microwave irradiation (100 W) afforded excellent […]Nguyen Dinh Thanh
- Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis March 23, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01046B, Research ArticleRongbin Wei, Xin Wang, Yamin Ding, Suting Zhu, Richmond Kwame Frimpong Asiedu, Muzi Li, Haitao Qian, Yifei Gu, Bailing JiangCompound Q-11 shows potent nanomolar antiproliferative activity in gastric cancer cells and induces ROS accumulation, mitochondrial dysfunction and cytoskeletal disruption.To cite this article before page numbers are assigned, […]Rongbin Wei
- The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles March 23, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00091F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pinky K. Naicker, Mariam Yacoub, Lisa J. White, Dominick E. Balderston, Perry A. Hailey, J. Mark Sutton, Charlotte K. Hind, Jennifer R. HiscockThe use of bioisosteres enhances the antimicrobial activity for a […]Pinky K. Naicker
- Design and biological evaluation of triagonist GLP-1R/GCGR/GIPR peptides as potential therapeutic agents for diabetes and obesity March 19, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01086A, Research ArticleIwona Kalinowska, Alicja Gawalska, Paulina Kasprzycka, Michał Stępniewski, Piotr Rózga, Aneta Pałka, Andrii Shubin, Katarzyna Bukato, Marlena Gałązka, Ewa Burchard, Paulina Zielińska-Świder, Albert Jaworski, Marcin FederRational design and molecular modelling enabled the development of potent GLP-1/GIP/GCGR triagonists with robust in vitro activity and efficacy comparable to established […]Iwona Kalinowska
- Beyond Infection Control: Exploring the Therapeutic Potential of Antimicrobials in Oncology and Their Synthetic Perspectives March 18, 2026RSC Med. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6MD00084C, Review ArticleMOHD YESHAB ANSARI, Rahul KumarThe repurposing of FDA-approved antimicrobial agents for oncology presents a promising therapeutic strategy to accelerate drug development and enhance clinical outcomes in cancer therapy. This strategy has gained significant interest...The content of this RSS Feed (c) The Royal Society of ChemistryMOHD YESHAB ANSARI
- Discovery of dihydrospiro[cyclopropane-1,7′-pyrrolo[3,4-d]pyrimidine] derivatives as novel ATR inhibitors March 16, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01127B, Research ArticleXiaozhen Chen, Yunbo Qian, Yitong Guo, Junfei Li, Lei Xu, Xingxing Zeng, Kailong Jiang, Yubo Zhou, Jia Li, Tao LiuNovel ATR inhibitors were developed using a scaffold hopping strategy, with compound 10h exhibiting favorable activity.To cite this article before page numbers are assigned, use the DOI form […]Xiaozhen Chen
- Design, synthesis and biological assessment of erlotinib-1,2,3-triazole derivatives for anticancer applications March 12, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D5MD01149C, Research ArticleQiyan Yao, Kexin Qu, Lan Wang, Mengmeng Huang, Longfei Mao, Sanqiang LiA series of novel erlotinib derivatives incorporating 1,2,3-triazole moieties were synthesized and evaluated for their anti-hepatocellular carcinoma activity both in vitro and in vivo.To cite this article before page numbers are assigned, use the DOI form […]Qiyan Yao
- Peptides as multifunctional linchpins in targeted drug conjugates March 9, 2026RSC Med. Chem., 2026, Advance ArticleDOI: 10.1039/D6MD00049E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xue Li, Yuechen Qian, Jiongjia Cheng, Qian ChuMultifunctional roles of peptides in peptide–drug conjugates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Xue Li
- Novel zerumbone-amide-triazole hybrids as potential NF-κB pathway inhibitors: design, synthesis, cytotoxicity evaluation, computational studies, and mechanistic insights March 26, 2026
