RSC – RSC Med. Chem. latest articles- Unravelling the Antibacterial Performances of A Homochiral D-configured Tetraphenylalanine appended 16-HPA Derivative based Mechanoresponsive and Proteolytically Stable Hydrogel November 1, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00728C, Research ArticleVaibhav Shivhare, Anindya Basu, Anita DuttKonarMicrobial Infection is one of the most pressing global challenges worldwide, that imposes significant economic burdens on healthcare systems. This work represents a rational combinatorial strategy that leverages hydrophobic harmony...The content of this RSS Feed (c) The Royal Society of ChemistryVaibhav Shivhare
- Identification of Spirodioxolane nsP2 Helicase Inhibitors with Antialphaviral Activity October 31, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00772K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Timothy M Willson, Hans Oh, John Sears, Muthu Bose Ramalingam, Rahman Shah Zaib Saleem, Zachary Davis-Gilbert, Mohammad Anwar Hossain, Stella Moorman, Durbadal Ojha, Sabian Martinez, Jane Burdick, Rafael Counago, Nathaniel Moorman, Mark […]Timothy M Willson
- Synthesis and evaluation of HFIP bearing triazolo-amides as amyloid-β aggregation inhibitor and suppressor of aggregation induced neuroinflammation October 30, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00481K, Research ArticleBhaskar Dewangan, Parijat Swain, Srimanta Patra, Praveen Reddy Bodhe, Neeraj Kulkarni, Bichismita SahuAlzheimer’s disease (AD) is a complex neurodegenerative disease with biological signatures of amyloid beta (Aβ) aggregated plaques and increased levels of bio-metals copper (Cu), zinc (Zn), and iron (Fe). Aβ-induced...The content of this RSS Feed […]Bhaskar Dewangan
- Evaluating the FEP+ protocol for predicting binding affinity of congeneric ligands towards various soluble proteins October 30, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00748H, Research ArticleShashi Kumar Sampangin Venkatesh, Arpan Das, Naga Rajiv LakkanigaGenerating libraries of congeneric series of compounds and development of structure-activity relationships (SAR) is a common practice among medicinal chemists. While various computational methods are available to guide scaffold optimization,...The content of this RSS Feed (c) The Royal Society […]Shashi Kumar Sampangin Venkatesh
- Sulfonation modification of peptides and their protective effect on angiotensin II-induced HK-2 cell injury October 30, 2025RSC Med. Chem., 2025, Advance ArticleDOI: 10.1039/D5MD00755K, Research ArticleShuqian Chen, Shuqi He, Siyi Song, Qianxia Lin, Xun He, Huoxi JinA sulfonated peptide, LR-7S, demonstrates enhanced water solubility, antioxidant activity, and ACE inhibition, effectively protecting renal cells from angiotensin II-induced damage, highlighting its potential for treating hypertensive nephropathy.To cite this article before page numbers are assigned, […]Shuqian Chen
- Novel magnolol-sulforaphane hybrids as potent antitumor agents: Synthesis and biological characterization October 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00733J, Research ArticleYuwei Peng, Bing Liu, Yishan Guo, Junhong Chen, Haoxiong Chen, Xueyi Liu, Junchang Huang, Daqiang Luo, Yimin Hong, Dudu Wu, Zhi Chen, Xian Lin, Tao ChengThe natural product-based hybrid strategy is a promising approach for innovative drug discovery. Leveraging the privileged architecture of sulforaphane—a prominent anticancer natural […]Yuwei Peng
- Bridging traditional and contemporary approaches in computational medicinal chemistry: opportunities for innovation in drug discovery October 29, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00700C, Review ArticleAldo Sena de OliveiraThe field of Computational Medicinal Chemistry has undergone significant advancements, transitioning from traditional methodologies to contemporary strategies powered by artificial intelligence, machine learning, and big data. Traditional approaches, such as...The content of this RSS Feed (c) The Royal Society of ChemistryAldo Sena de Oliveira
- Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein October 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00625B, Research ArticleLaura Depta, Nianzhe He, Maria Lillevang Madsen, Matilde Lind Hartvig Nielsen, Hogan P. Bryce-Rogers, Samantha C. Waterworth, Jeffrey D. Neighbors, David P. Stockdale, Michael P. Callahan, Nolan R. Mente, John Beutler, David Wiemer, Luca LaraiaSchweinfurthins (SWs) are natural products isolated from the plant genus Macaranga which display […]Laura Depta
- Identification of p-Aminobenzylamine Derivatives as Dual Non-Covalent Inhibitors of the Transmembrane Host Proteases TMPRSS2 and HAT Proteases with Anti-viral Potential October 28, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00680E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hélène Carvaillo, Ashok Dussol, Nancy Chaaya, Sara Kadri, Feryel Soualmia, Nicolas MASURIER, Chahrazade El AmriTMPRSS2 and HAT (or TMPRSS11D) are host serine proteases critically involved in the entry of several respiratory viruses, […]Hélène Carvaillo
- C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease October 27, 2025RSC Med. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5MD00789E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dorian-Gabriel Muntean, Wojtek Treyde, Linda Kinena, Eidarus Saleh, Hani Choudhry, Fernanda Duarte, Lennart Brewitz, Christopher J SchofieldInhibition of the SARS-CoV-2 main protease (Mpro) by small-molecules is a validated strategy for COVID-19 treatment. […]Dorian-Gabriel Muntean
- Unravelling the Antibacterial Performances of A Homochiral D-configured Tetraphenylalanine appended 16-HPA Derivative based Mechanoresponsive and Proteolytically Stable Hydrogel November 1, 2025
