RSC – Nat. Prod. Rep. latest articles- Natural product inspired antibiotics approved for human use – 1943 to 2025 December 11, 2025Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00067J, Review ArticleMark S. Butler, Robert J. CaponThis review captures the legacy of natural products in shaping modern infection control and highlights their potential for delivering the next generation of life-saving antibiotics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Mark S. Butler
- Engineering class I terpene synthases for skeletal diversity: strategies and applications December 10, 2025Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00066A, Review ArticleXingming Pan, Haixin Li, Liao-Bin DongThis review explores diverse engineering strategies for class I terpene synthases, from structure-guided rational design to mechanism-focused and evolutionary approaches, enabling skeletal diversification of terpenoids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Xingming Pan
- Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics December 3, 2025Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00040H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Joshua J. Kellogg, R. Teal Jordan, Madhusha M. Ranaweera, Kelsey Custer, Savannah G. Anez, Julia Bendlin, Francisco T. Chacon, Xiaoling ChenTo ensure safe and effective botanical products, the identity and integrity of […]Joshua J. Kellogg
- Hot off the Press November 27, 2025Nat. Prod. Rep., 2025, 42,1919-1923DOI: 10.1039/D5NP90047F, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as humulupone A from Humulus lupulus.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states November 18, 2025Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00064E, HighlightHidayat Hussain, K. N. Houk, Ching Ching Lam, Satyajit D. Sarker, Lutfun NaharThis review describes enzyme-catalyzed reactions involving ambimodal transition states, and recent advances in understanding how enzymes control selectivity in such reactions.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Hidayat Hussain
- Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives September 29, 2025Nat. Prod. Rep., 2025, 42,2075-2096DOI: 10.1039/D5NP00045A, Review ArticleMartinus de Kruijff, Sebastian Götze, Christine BeemelmannsMetallophores are vital for microbial survival as they mediate metal bioavailability. Yersiniabactin-type metallophores are unique in biosynthesis and structure, with specialized functions that support immune evasion, nutrient acquisition, and niche colonization.The content of this RSS Feed (c) The Royal Society of ChemistryMartinus de Kruijff
- Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria September 11, 2025Nat. Prod. Rep., 2025, 42,2034-2074DOI: 10.1039/D5NP00048C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Weimao Zhong, Zhenjian Lin, Eric W. Schmidt, Vinayak AgarwalSponges are prolific sources of peptidic natural products. Here, the discovery, biosynthesis, and bioactivities of peptidic natural products from all components of the marine sponge […]Weimao Zhong
- The oxidative rearrangements in bacterial aromatic polyketide biosynthesis September 9, 2025Nat. Prod. Rep., 2025, 42,1990-2033DOI: 10.1039/D5NP00049A, Review ArticleFangwen Jiao, Shuai Li, Hongzhi Qiao, Ruihua JiaoIn this review article, we focus on the chemical and enzymatic mechanisms of carbon skeleton rearrangements in aromatic polyketide biosynthesis.The content of this RSS Feed (c) The Royal Society of ChemistryFangwen Jiao
- Rotenoid diversity, distribution and evolution in plant lineages September 8, 2025Nat. Prod. Rep., 2025, 42,1936-1945DOI: 10.1039/D5NP00054H, HighlightVaderament-A. Nchiozem-Ngnitedem, Alan Paton, Gabin Thierry M. BitchagnoThis highlight revisits rotenoid classification and provides a thorough understanding of how their occurrences could inform plant taxonomy.The content of this RSS Feed (c) The Royal Society of ChemistryVaderament-A. Nchiozem-Ngnitedem
- Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis August 14, 2025Nat. Prod. Rep., 2025, 42,1946-1989DOI: 10.1039/D5NP00032G, Review ArticleYujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan ZhangThis review covers natural polycyclic aromatic hydrocarbons with more than two fused rings conforming to Hückel's rule. The comprehensive summary includes their structural classification, bioactivity, biosynthesis, and chemical synthetic studies.The content of this […]Yujian Mao
- Dietary substances and their glucuronides: structures, occurrence and biological activity June 3, 2025Nat. Prod. Rep., 2025, 42,1924-1935DOI: 10.1039/D5NP00002E, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Andrew V. Stachulski, Edwin A. Yates, Aleksandra Teriosina, Lesley Hoyles, Simon McArthurWe survey glucuronides of polyphenolic dietary substances and discuss their activities in comparison to those of the parent compounds. We finally consider the […]Andrew V. Stachulski
- Natural product inspired antibiotics approved for human use – 1943 to 2025 December 11, 2025
