RSC – Food Funct. latest articles- 6-Shogaol inhibits cell motility by suppressing the PI3K/AKT/mTOR and Ras/Raf/MAPK pathways with effects comparable to paclitaxel treatment in prostate cancer cells May 7, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00798D, PaperPei-Jhen Cai, Sheng-Yi Chen, Yi-Fan Chen, Gow-Chin YenProstate cancer ranks among the top causes of cancer-related deaths in men, with a substantial number of fatalities occurring in metastatic cases. Although paclitaxel (PTX) is used as a first-line...The content of this RSS Feed (c) The Royal Society of ChemistryPei-Jhen Cai
- Impact of Mucin Protein Corona on the Gastrointestinal Behavior and Antioxidant Activity of Food Carbon Dots Extracted from Bread Crust May 6, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00088B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shichao Mi, Zimo Liu, Mingcheng Wang, David J. McClements, Chongjiang Cao, Xiao Xu, Biao YuanBread products are widely consumed around the globe, as they are a staple food in many countries. Recent studies have […]Shichao Mi
- Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis May 6, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00422E, PaperQianye Zhang, Mingxiao Zheng, Wei Sun, Gabriele Loers, Min Wen, Qing-Peng Wang, Xuexing Zheng, Hans-Christian Siebert, Ruiyan Zhang, Ning ZhangThe activation of microglia is an important cause of central nervous system (CNS) inflammatory cell infiltration and inflammatory demyelination in multiple sclerosis (MS). NOD-, LRR- and pyrin domain-containing protein 3...The […]Qianye Zhang
- Extraction, purification, structural characterization and bioactivity of maize oligosaccharides: a review May 6, 2025Food Funct., 2025, Advance ArticleDOI: 10.1039/D5FO00791G, Review ArticleHongmei Deng, Borui Guan, Qingfang Deng, Xin Zhou, Huaguo ChenMaize (Zea mays L.), as a globally significant food and economic crop, has attracted considerable attention from both the academic and industrial sectors due to its rich nutrient components and wide-ranging application value.To cite this article before page numbers […]Hongmei Deng
- Effects of the DailyColors™ Polyphenol Supplement on Serum Proteome, Cognitive Function, and Health in Older Adults at Risk of Cognitive and Functional Decline. May 5, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D4FO06259K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mary F. O'Leary, Joanna Bowtell, Megan Richards, Esra Bozbaş, Abbie Palmer, Kate Stych, Monica Meng, Adam Bloomfield, Lauren Struszczak, Jack Pritchard, Celeste Lugtmeijer, George Vere, Raif Yücel, Ana Rodriguez-Mateos, Zicheng Zhang, Jonathan CY Tang, […]Mary F. O'Leary
- Reshaping gut microbiota to ameliorate DSS-induced colitis by a novel synbiotic consisting of Jujube Powder and Faecalibacterium prausnitzii May 5, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D4FO04815F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yalin Zhou, Zhenghuan Yang, Huiren Zhuang, Tianhao Chen, Sherlyn Sze Ning Koay, Ran Li, Guoqiang Jiang, Zheng LiuUlcerative colitis (UC) remains challenging to existing therapeutic approaches, which may appear variable efficacy, side effects, and […]Yalin Zhou
- Absorption and immune-modulating effects of active peptides from Hericium erinaceus protein treated with gastrointestinal model in vitro May 4, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00590F, PaperJunmiao Zhang, Qiuhui Hu, Gaoxing Ma, Anxiang Su, Liyan Zhao, Hengjun Du, Hang XiaoThe mechanism by which fungal proteins retain immunomodulatory activity after gastrointestinal digestion remains unknown. To shed light on the mechanism, the protein and peptides from Hericium erinaceus were explored through...The content of this RSS Feed (c) […]Junmiao Zhang
- Effects of Fish Oil Intervention on Type 2 Diabetes Early Risk Novel Biomarkers in Healthy Middle-Aged and Elderly Adults: a Double-Blind Randomized Controlled Trial May 4, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO01018G, PaperZhaoyang Nian, Yuting Lin, Wei Tang, Chunxia Quan, Jing Wen, Xinqian Jin, Zheqing Zhang, Limei MaoObjective: Recent studies on type 2 diabetes (T2D) have identified several novel biomarkers that demonstrate greater stability compared to traditional blood glucose indicators. This trial aimed to investigate the effect...The content of this RSS […]Zhaoyang Nian
- Deglet Noor Dates Derived Polysaccharides Lower Blood Glucose Levels and Modulate Gut Microbiota in a Streptozotocin-Induced Type-1 Diabetic Mouse Model May 2, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00128E, PaperHidayat Ullah, Yamina I ALIOU, Xiaoye Liu, Sharafat Ali, Bing Tang , Hongmei Lu , Yongdui Ruan , Xianjing HuBackground: Diabetes mellitus is a chronic and multifaceted condition characterized by metabolic disruptions in carbohydrates, proteins, and fats, leading to insulin deficiency and hyperglycemia. Despite the availability of chemical drugs,...The […]Hidayat Ullah
- Exploring the lipid-lowering effects of cinnamic acid and cinnamaldehyde from the perspective of gut microbiota and metabolites May 1, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00384A, PaperXueke Wang, Tianxing Li, Ling Dong, Yilin Li, Hong Ding, Jing Wang, Yuqi Xu, Wenlong Sun, Lingru LiThe increasing incidence and associated metabolic complications pose major challenges in the treatment of hyperlipidaemia. Cinnamon is a food and medicinal resource associated with lipid metabolism, but the mechanism by...The content of […]Xueke Wang
- Intermittent and Limited Exposure to a High-Fat Diet Prevents Social Defeat-Induced Increase in Ethanol Intake and Neuroinflammation May 1, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00584A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.M. Carmen Arenas, Irene Pérez-Esteban, Héctor Cañeque-Rufo, Esther Gramage, Gonzalo Herradón, Marta RodriguezSocial stress is widely recognized for increasing ethanol consumption, an effect mediated by an enhanced neuroinflammatory response. High-fat diets (HFDs) alleviate stress […]M. Carmen Arenas
- Proteome evaluation of the biological activity of grape seed extract (GSE) on the intestine of rats April 30, 2025Food Funct., 2025, Advance ArticleDOI: 10.1039/D4FO05133E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eduardo Guisantes-Batán, Sara Artigas-Jerónimo, Lorena Mazuecos, Blanca Rubio, Elena Bonzón-Kulichenko, Sergio Gómez, Margarita Villar, Nilda GallardoChronic GSE supplementation modulates calcium signaling and mitochondrial efficiency in the ileum of healthy rats. Proteomic analysis reveals reduced […]Eduardo Guisantes-Batán
- Food microstructure and protein digestion in the human gastrointestinal tract: an ileostomy study focusing on interindividual variability in gluten digestibility April 30, 2025Food Funct., 2025, Advance ArticleDOI: 10.1039/D4FO04508D, PaperDaniela Freitas, Joan Colom, Laura G. Gómez-Mascaraque, Annie Simon, Kieran Rea, Alison Winger, Martin Buckley, John Deaton, André BrodkorbSubstantial interindividual differences in cumulative amounts of potentially immunogenic gliadin fragments in ileal effluent suggest high variability in the individual capacity to hydrolyse gluten proteins in the upper gastrointestinal tract.To cite […]Daniela Freitas
- Supplementation of low-protein diets with plant protein and probiotics enhances muscle health by regulating gut microbiota and metabolomic profiles in SAMP8 mice April 30, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO01400J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ruyi Han, Limin Ouyang, Chenggang Yin, Long Cai, Qiming Wu, Liang Chen, Jun Du, Xilong Li, Zhigang Zhu, Yu PiMuscle health is crucial, especially for aging populations. This study examines how plant protein and […]Ruyi Han
- Hypoglycemic potential of sugarcane molasses-derived polyphenols: exploring the hypoglycemic mechanisms through in vitro α-glucosidase inhibition and intracellular glucose transport inhibition April 30, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00090D, PaperXu Zhao, Jianwen Zhao, Chun CuiSugarcane molasses， a by-product of the sugar manufacturing process, is rich in polyphenols and possesses potential physiological activities. This study aimed to extract and purify polyphenols from sugarcane molasses and...The content of this RSS Feed (c) The Royal Society of ChemistryXu Zhao
- Association between the quality of plant-based diets and risk of thyroid dysfunction April 29, 2025Food Funct., 2025, Advance ArticleDOI: 10.1039/D4FO04287E, PaperJuanjuan Zhang, Yuchuan He, Zhiyuan Tang, Chang Liu, Baojun Song, Chao Liu, Yang XiaHealthy plant foods may confer protective effects on the thyroid gland, whereas animal-derived foods could potentially harm the thyroid gland by generating ROS that increase oxidative stress and inflammatory reactions.To cite this article before page numbers […]Juanjuan Zhang
- Time-of-day-dependent effects of a green tea extract on postprandial glycemia and insulinemia in healthy adults: a randomized, controlled, double-blind, cross-over intervention April 27, 2025Food Funct., 2025, Advance ArticleDOI: 10.1039/D4FO04843A, PaperNoha Sulaimani, Erika J. Rosbotham, Rebekah Warnock, Louise Polzella, Rebecca Judowski, Luca Nicolotti, Michael J. Houghton, Gary Williamson, Maxine P. BonhamTime-of-day-dependent effects of a green tea extract on postprandial glucose and insulin concentrations. Created with https://www.biorender.com/ and the female photo taken from https://www.vecteezy.com/.To cite this article before page numbers […]Noha Sulaimani
- Investigating the Neuroprotective Effects of Polyunsaturated Fatty Acids in Egg Yolk Phospholipids on Oxidative Damage in HT22 Cells April 27, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00833F, PaperJingyu Li, Bing Fang, Yao Wu, Yuhang Sun, Yue Liu, haina gao, Ming ZhangEgg yolk phospholipids are primarily composed of various fatty acids, lysophosphatidylcholine and lysophosphatidylethanolamine. Existing studies demonstrated the neuroprotective activity of egg yolk phospholipids, however, which products of these compounds after...The content of this RSS Feed (c) […]Jingyu Li
- Ferulic acid identification in brown rice using untargeted metabolomics and network analysis and its effects in mitigating AFB1-induced hepatic damage April 27, 2025Food Funct., 2025, Accepted ManuscriptDOI: 10.1039/D5FO00178A, PaperQianqian Wang, Gaigai Wang, Yanan Wang, Xin Fang, Yutong Fu, Guiming Li, Shimeng Huang, Qiu-Gang Ma, Lihong ZhaoRegular consumption of brown rice has been linked to reduce the probability of oxidative stress-related diseases, including diabetes, alzheimer's disease and cancer. The higher abundance of bioactive metabolites, including polyphenols...The content of […]Qianqian Wang
- Synergistic effect of 2′-fucosyllactose and osteopontin on intestinal mucosal immunity injury April 27, 2025Food Funct., 2025, Advance ArticleDOI: 10.1039/D4FO05287K, PaperRui Zhang, Sufang Duan, Xinming Ma, Zhengtao Guo, Ignatius Man-Yau Szeto, Xiaodan Shi, Congrui Zhao, Yalu Yan, Bailiang Li2′-FL and OPN synergistically alleviates LPS-induced intestinal barrier damage in rats via improved barrier function, reduced inflammation, balanced immunity, and modulated microbiota.To cite this article before page numbers are assigned, use […]Rui Zhang
- 6-Shogaol inhibits cell motility by suppressing the PI3K/AKT/mTOR and Ras/Raf/MAPK pathways with effects comparable to paclitaxel treatment in prostate cancer cells May 7, 2025
