RSC – Nat. Prod. Rep. latest articles- Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis August 4, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00043B, Review ArticleChunlei Zhao, Jinyi Qian, Xiulai ChenThis review outlines how microbial engineering enables sustainable production of natural and unnatural glycosaminoglycans, replacing conventional chemical methods.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Chunlei Zhao
- Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products July 31, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00030K, Review ArticleJi-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong ZhangAlkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryJi-Wei Sang
- para-Quinone methides in natural product biosynthesis July 31, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00044K, HighlightJie Gao, Qibin Chen, Qi ZhangThis highlight focuses on nature's strategic use of highly reactive para-quinone methides (p-QMs) as key intermediates in natural product biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Jie Gao
- Hot off the Press July 30, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP90029H, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hypbeaone A from Hypericum beanii.To cite this article before page numbers are assigned, use the DOI […]Robert A. Hill
- Semi-synthesis in the exploration of opioid-targeting natural products July 29, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00029G, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrew P. RileyChemically modifying a natural product can be a powerful tool for studying and optimizing its biological activity. This highlight presents recent examples of applying this approach to investigate natural products that […]Andrew P. Riley
- The development of Burkholderia bacteria as heterologous hosts July 27, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00024F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stephanie C. Heard, Alessandra S. EustáquioWe review Burkholderia bacterial strains that have been tested as heterologous hosts and the natural products obtained. We also compare host characteristics and their stage of development.To […]Stephanie C. Heard
- Recent progress of [5 + 2] cycloaddition reactions in natural product synthesis July 27, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00023H, Review ArticleNan Wang, Yu Bai, Qingyi Zeng, Tao Zhang, Jun DengA systematic review of three major types of [5 + 2] cycloaddition reactions in natural product synthesis (2013–2024), highlighting their power in constructing complex frameworks through direct comparisons with alternative synthetic strategies.To cite this article before page numbers […]Nan Wang
- Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering July 27, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00041F, Review ArticleBiyan Chen, Emre F. Bülbül, SeoungGun Bang, Hannah A. Minas, Kenan A. J. BozhüyükThis review outlines integrated platforms combining genome mining, computational design, synthetic biology, and high-throughput screening to enable the programmable biosynthesis of tailor-made natural products.To cite this article before page numbers are assigned, use the […]Biyan Chen
- Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions July 27, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00028A, Review ArticleRui Liu, Xiao-Ping Peng, David J. Newman, Diane Purchase, Gang Li, Souvik KusariThis review offers a comprehensive analysis of epigenetics and its crucial role in the production of secondary metabolites by endophytic fungi. Strategic epigenetic modulation could enhance drug discovery initiatives involving fungal endophytes.To cite this article […]Rui Liu
- Spiroketal natural products isolated from traditional Chinese medicine: isolation, biological activity, biosynthesis, and synthesis July 20, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00035A, Review ArticleEilidh G. Young, Freda F. Li, Margaret A. BrimbleIn this review, we examine the origins and synthesis of bioactive spiroketal-containing natural products isolated from traditional Chinese medicines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Eilidh G. Young
- Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides July 15, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00042D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shumpei AsamizuThis highlight focuses on the recent advances in the discovery and biosynthesis of bioactive lipopeptide natural products derived from ribosomally synthesized and post-translationally modified peptides.To cite this article before page numbers […]Shumpei Asamizu
- Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery July 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00016E, ViewpointBenjamin Philmus, Nicole E. Avalon, Yousong Ding, Drew T. Doering, Alessandra S. Eustáquio, William H. Gerwick, Hendrik Luesch, Jimmy Orjala, Shaz Sutherland, Arnaud Taton, Daniel UdwaryCyanobacteria are prolific producers of bioactive natural products. In this article, we outline some challenges faced in exploiting cyanobacteria for drug discovery, current […]Benjamin Philmus
- Natural products targeting the metabolism of amino acids: from discovery to synthetic development July 10, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00039D, Review ArticleHyun Su Kim, Ahmed H. E. Hassan, Kyuho Moon, Jaehoon SimAmino acid metabolism is essential to homeostasis, immune regulation, and disease. This review highlights natural products that modulate these metabolic pathways and outlines synthetic strategies to enhance their therapeutic potential.To cite this article before page numbers are […]Hyun Su Kim
- Recent advances in the chemistry and biology of plant oxylipin hormones April 24, 2025Nat. Prod. Rep., 2025, 42,1175-1194DOI: 10.1039/D5NP00006H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yuho Nishizato, Taichi Okumura, Kotaro Matsumoto, Minoru UedaOxylipin plant hormone jasmonates induce various plant responses, including defense against attacks of insects or pathogens and tolerance against environmental stresses. Jasmonates function as unique “molecular […]Yuho Nishizato
- Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria April 24, 2025Nat. Prod. Rep., 2025, 42,1195-1225DOI: 10.1039/D5NP00013K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jeong-A. Kim, Si-sun Choi, Jae Kyu Lim, Eung-Soo KimDiscovery of bioactive natural products from sponge-associated microbes via innovative cultivation and genome-guided approaches.The content of this RSS Feed (c) The Royal Society of ChemistryJeong-A. Kim
- Configurational assignments of type-I polyketide synthase (PKS)-derived natural products based on spectroscopic and chemical analysis: methodologies and case studies April 22, 2025Nat. Prod. Rep., 2025, 42,1136-1174DOI: 10.1039/D4NP00061G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinsheng Cui, Prima F. Hillman, Geum Jin Kim, Thinh T. M. Bui, Kyuho Moon, Sang-Jip Nam, Hyukjae Choi, Dong-Chan OhA comprehensive review on the challenges and methods for determining the stereochemistry of type-I […]Jinsheng Cui
- Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ April 16, 2025Nat. Prod. Rep., 2025, 42,1063-1070DOI: 10.1039/D4NP00070F, Viewpoint Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel JasparsA viewpoint article for the scientific community examining the implications of new genetic resource policies on marine natural product research.The content of this RSS Feed (c) The […]Federica Casolari
- Modulators of the ubiquitin–proteasome system from natural products: chemical structures and their potential for drug discovery April 13, 2025Nat. Prod. Rep., 2025, 42,1120-1135DOI: 10.1039/D5NP00004A, Review ArticleYuki Hitora, Sachiko TsukamotoThis review describes natural products that modulate the ubiquitin–proteasome system and their potential for therapeutic agents and the study of life science.The content of this RSS Feed (c) The Royal Society of ChemistryYuki Hitora
- The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism April 9, 2025Nat. Prod. Rep., 2025, 42,1091-1119DOI: 10.1039/D5NP00003C, Review ArticleXinjie ShiBisintercalators are a family of cyclic peptides produced by actinobacteria, with the ability to bisintercalate into DNA molecules. We provide a nearly comprehensive list of this family of compounds and summarize their biosynthetic mechanisms.The content of this RSS Feed (c) The Royal Society of ChemistryXinjie Shi
- Intramolecular cycloaddition of nitrones in total synthesis of natural products March 10, 2025Nat. Prod. Rep., 2025, 42,1071-1090DOI: 10.1039/D4NP00062E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Satoshi YokoshimaThis review highlights the intramolecular cycloaddition of nitrones as a valuable tool in the total synthesis of natural products, facilitating the construction of complex skeletons and the introduction of functional groups.The content […]Satoshi Yokoshima
- Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis August 4, 2025
