RSC – Nat. Prod. Rep. latest articles- Natural products influence bacteriophage infectivity August 17, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00014A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zhiyu Zang, Joseph P. GerdtThis review comprehensively reports historical and recent examples of natural products that either prevent bacteriophages from infecting bacteria, promote those infections, or regulate the induction of the lytic […]Zhiyu Zang
- Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis August 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00032G, Review ArticleYujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan ZhangThis review covers natural polycyclic aromatic hydrocarbons with more than two fused rings conforming to Hückel's rule. The comprehensive summary includes their structural classification, bioactivity, biosynthesis, and chemical synthetic studies.To cite this […]Yujian Mao
- Coprophilous fungi in the search for new antimicrobials and other beneficial natural products August 7, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00015G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Esteban Charria-Girón, Joseph Tchamgoue, Marc Stadler, Yasmina Marin-FelixThis review focuses on the chemical diversity of secondary metabolites produced by coprophilous fungi, i.e. those that inhabit or are associated with animal dung, with […]Esteban Charria-Girón
- Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis August 4, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00043B, Review ArticleChunlei Zhao, Jinyi Qian, Xiulai ChenThis review outlines how microbial engineering enables sustainable production of natural and unnatural glycosaminoglycans, replacing conventional chemical methods.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Chunlei Zhao
- Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products July 31, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00030K, Review ArticleJi-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong ZhangAlkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryJi-Wei Sang
- para-Quinone methides in natural product biosynthesis July 31, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00044K, HighlightJie Gao, Qibin Chen, Qi ZhangThis highlight focuses on nature's strategic use of highly reactive para-quinone methides (p-QMs) as key intermediates in natural product biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Jie Gao
- Hot off the Press July 30, 2025Nat. Prod. Rep., 2025, 42,1235-1239DOI: 10.1039/D5NP90029H, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hypbeaone A from Hypericum beanii.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Semi-synthesis in the exploration of opioid-targeting natural products July 29, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00029G, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrew P. RileyChemically modifying a natural product can be a powerful tool for studying and optimizing its biological activity. This highlight presents recent examples of applying this approach to investigate natural products that […]Andrew P. Riley
- The chemical and biological properties of natural resorcylic acid lactones June 18, 2025Nat. Prod. Rep., 2025, 42,1387-1410DOI: 10.1039/D5NP00033E, Review ArticleYing Gao, Wanpeng Li, Hanli RuanThis review highlights the classification, structures, origins, biotargets, and clinical studies of naturally derived resorcylic acid lactones, a valuable polyketide template for drug discovery.The content of this RSS Feed (c) The Royal Society of ChemistryYing Gao
- Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids June 9, 2025Nat. Prod. Rep., 2025, 42,1251-1264DOI: 10.1039/D5NP00025D, HighlightChungwoo Lee, Sunkyu HanThis Highlight reviews the discovery, structure elucidation, (bio)synthesis, and applications of securingines A–I, highly oxidized securinega alkaloids with unique structures.The content of this RSS Feed (c) The Royal Society of ChemistryChungwoo Lee
- Advances in the discovery and study of Trichoderma natural products for biological control applications June 5, 2025Nat. Prod. Rep., 2025, 42,1367-1386DOI: 10.1039/D5NP00017C, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sophie Jin, Fabrizio AlbertiTrichoderma spp. are talented producers of bioactive natural products, with applications in crop protection and growth promotion. We describe methods for the discovery of these compounds focused mainly on cultivation, […]Sophie Jin
- Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications May 19, 2025Nat. Prod. Rep., 2025, 42,1276-1302DOI: 10.1039/D5NP00018A, Review ArticleYanqing Xue, Yijiao Xiong, Wei Huang, Jianing Liu, Wen LiuPosttranslational modifications characterized over the past decade to engage the –(NH–Cα–CO)n– repeating units in transformations are highlighted, particularly those leading to structural rearrangements by peptide backbone remodeling.The content of this RSS Feed (c) The Royal Society of ChemistryYanqing Xue
- Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin May 15, 2025Nat. Prod. Rep., 2025, 42,1344-1366DOI: 10.1039/D5NP00012B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark Ellerhorst, Vadim Nikitushkin, Walid K. Al-Jammal, Lucas Gregor, Ivan Vilotijević, Gerald LacknerMycofactocin is a peptide-derived redox cofactor, commonly present in mycobacteria. This review covers its structural diversity, synthesis, biosynthesis and biochemical functions. […]Mark Ellerhorst
- Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity May 14, 2025Nat. Prod. Rep., 2025, 42,1303-1343DOI: 10.1039/D5NP00011D, Review ArticleFan Zhang, Di Zhao, Yuzhu Wu, Lei LiThis review highlights the occurrence, structures, biosynthesis and bioactivities of prenylated bacterial natural products and outlines the mechanistic study of cluster-situated prenyltransferases for the development of novel biocatalysts.The content of this RSS Feed (c) The Royal Society of ChemistryFan Zhang
- Recent highlights of the total synthesis of cyclic peptide natural products May 13, 2025Nat. Prod. Rep., 2025, 42,1265-1275DOI: 10.1039/D4NP00056K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Takayuki Doi, Masaya Kumashiro, Kosuke OhsawaThis review described the total synthesis of naturally occurring cyclic peptides covering 2020 to 2022 paying particular attention to the construction of their unique structures via macrocyclization.The content […]Takayuki Doi
- Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products April 15, 2025Nat. Prod. Rep., 2025, 42,1240-1250DOI: 10.1039/D5NP00009B, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Manyun Chen, Dipesh Dhakal, Campbell W. Eckhardt, Hendrik Luesch, Yousong DingWe focus on recent advances in synthetic biology strategies for the heterologous production of cyanobacterial natural products in cyanobacterial hosts, showcasing key examples across […]Manyun Chen
- Natural products influence bacteriophage infectivity August 17, 2025
