RSC – Nat. Prod. Rep. latest articles- Cinnamoyl-containing non-ribosomal peptides: discovery, bioactivity and biosynthesis June 18, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00084J, Review ArticleYuyang Wang, Yanqing Li, Yingying Chen, Jianhua Ju, Zhuo Shang, Junying MaThe chemical diversity, biological activities, biosynthesis and expanding chemical diversity of cinnamoyl-containing non-ribosomal peptides.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Yuyang Wang
- Challenges and opportunities in the synthesis of biologically relevant flavonoids and their glycosides June 18, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00008H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Debabrata Giri, Saikat Mondal, M. Carmen Galan, Abhijit SauThis review provides a current perspective on the recent advancements in flavonoid chemistry and their role in the development of novel therapeutic agents.To cite […]Debabrata Giri
- The elansolids: how nature shows chemists how to tame p-quinone methides June 18, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00030D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Liang-Liang Wang, Xiao-Qin Zhou, Andreas KirschningUsing elansolids as a case study, it is demonstrated how nature tames the highly reactive p-quinone methide by controlling its reactivity and conformation in a very efficient […]Liang-Liang Wang
- Decoding multidimensional regulatory networks in Streptomyces to accelerate natural product discovery and production June 17, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00022C, Review ArticleYongjae Lee, Woori Kim, Chanyoung Joung, Hyeseong Kim, Namil Lee, Byung-Kwan ChoAdvances in genome-scale analytical tools have expanded our knowledge of regulatory networks in Streptomyces, providing a transferable framework for the systematic activation of biosynthetic gene clusters for natural product discovery and production.To cite this article before […]Yongjae Lee
- Mass spectrometry as the unifying force in natural product sciences June 14, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP90018F, EditorialMehdi A. Beniddir, Nadja B. Cech, Roger Linington, Neha GargMehdi A. Beniddir, Nadja B. Cech, Roger Linington and Neha Garg introduce the Natural Product Reports themed issue on Mass spectrometry metabolomics in natural products research.To cite this article before page numbers are assigned, use the DOI form of […]Mehdi A. Beniddir
- Emerging technologies for the discovery of biosynthetic genes in plants June 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00011H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anne Jaczkowski, Arne Bültemeier, Benedikt Seligmann, Boas Pucker, Jakob FrankeCompared to microbial natural product research, elucidating biosynthetic pathways in plants requires distinct methodological approaches. This review describes emerging technologies for discovering biosynthetic […]Anne Jaczkowski
- Ecological context for bacterial natural products discovery June 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00018E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonathan Parra, Marla I. Macias-Contreras, Dulce G. Guillén Matus, Katherine R. DuncanThis review highlights recent studies and considerations towards ecological approaches to natural product discovery.To cite this article before page numbers are […]Jonathan Parra
- Microbial biotransformation of plant-derived metabolites: mechanisms, pathways, and multi-omics integration June 9, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00039H, Review ArticleYoungse Oh, Jaeyoun Lee, Soohyun Um, Seung Hyun KimThis review presents a reaction-class atlas of microbial biotransformations of plant-derived metabolites and highlights how enzymatic mechanisms and multi-omics approaches reveal metabolic diversity in complex microbial communities.To cite this article before page numbers are assigned, use the DOI form […]Youngse Oh
- Hot off the Press June 9, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP90022D, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as humupulusone A from Humulus lupulus.To cite this article before page numbers are assigned, use the DOI […]Robert A. Hill
- Rare functional groups and unique scaffolds in Streptomyces natural products June 7, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00012F, Review ArticleSanyuan Shi, Xuerui Jin, Gaoli Wang, Xuewei Hao, Jing Xie, Liujie Huo, Yunzi LuoThis review highlights Streptomyces natural products with rare functional groups, unique scaffolds, and atypical modifications, examining the enzymatic mechanisms to link biosynthetic diversity with synthetic biology applications.To cite this article before page numbers are […]Sanyuan Shi
- Advances in the discovery and functional analysis of Anti-infective and immunomodulatory natural products from host-associated microbiomes June 4, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00003G, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Götze, Christine BeemelmannsThis review highlights discoveries from 2018 to 2025 of microbiome-derived natural products with anti-infective and immunomodulatory actvities, and urges to more targeted OMICs approaches to fully harness the encoded […]Sebastian Götze
- Natural products with atypical atoms: unveiling structures, biosynthetic pathways, and bioactivities June 3, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00083A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yeo Jin Lee, Hyeon-Jeong Hwang, Jungro Lee, Hyeon Seung Park, Juwan Son, Mohammad Seyedsayamdost, Munhyung Bae, Seoung Rak Lee, Yun KwonRare elements in natural products unlock new chemical space, biosynthetic logic, and […]Yeo Jin Lee
- Inverse stable isotopic labeling for natural product characterization and discovery June 2, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00014B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jose Miguel D. Robes, Aaron W. PuriThis review highlights applications of inverse stable isotope labeling in natural product research, including biosynthesis, structural elucidation, and discovery, spanning 2005 to 2026.To cite this article […]Jose Miguel D. Robes
- Synthetic biology as a game-changer for endangered medicinal orchids: biosynthesis, engineering and conservation June 1, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00027D, Review ArticleLin Qiu, Xianghui Chen, Zhan Luo, Min Jiang, Hu Chen, Biyu Hou, Haizheng Yu, Ning Li, Lei ZhangSynthetic biology acts as a game-changer for endangered medicinal orchids, enabling a transition from resource scarcity and extraction inefficiency to sustainable conservation through pathway decoding, chassis engineering and green biomanufacturing.To […]Lin Qiu
- Unlocking hidden enzymatic chemistry in natural product biosynthesis June 1, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00034G, HighlightMicah Harris, Asher Paul, Edward KalkreuterThis highlight reviews many of the existing and emerging strategies for prioritizing and accessing novel enzymology from microbial biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Micah Harris
- From gene discovery to synthetic biology: recent advances in the biosynthesis of oleanane-type pentacyclic triterpenoids May 25, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00013D, Review ArticleIsmail Abdelsamad, Mohamed Abdulbagi, Jingya Wang, Zheyong Xue, Xu LuThis review discusses recent progress in biosynthetic enzymes, regulatory networks, and synthetic biology strategies for oleanane-type triterpenoids, including AI-driven predictive optimization for sustainable production.To cite this article before page numbers are assigned, use the DOI form of citation […]Ismail Abdelsamad
- Charting the path for L-tyrosine derivatives: from engineering strategies to microbial cell factories March 24, 2026Nat. Prod. Rep., 2026, 43,1026-1062DOI: 10.1039/D5NP00091B, Review ArticleLi Zhou, Xulei Shi, Hui Jiang, Yuanyuan Xia, Haiquan Yang, Wei Shen, Yu Cao, Xianzhong ChenReview highlights cutting-edge advances in producing L-tyrosine derivatives via tyrosol, p-coumaric acid, and L-DOPA nodes in E. coli and yeast.The content of this RSS Feed (c) The Royal Society of ChemistryLi Zhou
- Highlights of cyanobacterial metabolites reported between 2021–2024 March 16, 2026Nat. Prod. Rep., 2026, 43,1008-1025DOI: 10.1039/D5NP00076A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Simon Sieber, Elisabeth M.-L. JanssenThis review provides an overview of newly identified cyanobacterial metabolites from 2021 to 2024. The discovery of specific natural products is discussed.The content of this RSS Feed (c) The […]Simon Sieber
- Decision making by modular polyketide synthases and implications for genetic engineering March 13, 2026Nat. Prod. Rep., 2026, 43,961-1007DOI: 10.1039/D6NP00010J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kira J. WeissmanThis review details the many choices underlying faithful biosynthesis of complex polyketides in bacteria, and highlights the implications for genetic engineering aiming to generate novel derivatives.The content of this RSS Feed […]Kira J. Weissman
- Quinic acid as a chiron in total synthesis March 3, 2026Nat. Prod. Rep., 2026, 43,932-960DOI: 10.1039/D5NP00087D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manuel J. Verganista, Iago C. Vogel, Nuno R. CandeiasQuinic acid is a versatile chiral building block in asymmetric synthesis, enabling diverse natural products and bioactive compounds. This review highlights four decades of strategies, […]Manuel J. Verganista
- Cinnamoyl-containing non-ribosomal peptides: discovery, bioactivity and biosynthesis June 18, 2026
