RSC – Nat. Prod. Rep. latest articles- Scalability of mass spectrometry-based metabolomics for natural extracts libraries exploration: current status, challenges, and opportunities September 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00034C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Adriano Rutz, Wout Bittremieux, Robin Schmid, Olivier Cailloux, Justin J. J. van der Hooft, Mehdi A. BeniddirThis review aims at highlighting how scalability of the mass spectrometry-based discovery pipeline plays a pivotal […]Adriano Rutz
- Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria September 11, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00048C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Weimao Zhong, Zhenjian Lin, Eric W. Schmidt, Vinayak AgarwalSponges are prolific sources of peptidic natural products. Here, the discovery, biosynthesis, and bioactivities of peptidic natural products from all components of the marine […]Weimao Zhong
- The oxidative rearrangements in bacterial aromatic polyketide biosynthesis September 9, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00049A, Review ArticleFangwen Jiao, Shuai Li, Hongzhi Qiao, Ruihua JiaoIn this review article, we focus on the chemical and enzymatic mechanisms of carbon skeleton rearrangements in aromatic polyketide biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Fangwen Jiao
- Natural product-derived compounds in clinical trials and drug approvals September 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00031A, Review ArticleMark S. Butler, Robert J. Capon, Mark A. T. Blaskovich, Ian R. HendersonNatural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine.To cite this article before page numbers are assigned, use the DOI form […]Mark S. Butler
- Rotenoid diversity, distribution and evolution in plant lineages September 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00054H, HighlightVaderament-A. Nchiozem-Ngnitedem, Alan Paton, Gabin Thierry M. BitchagnoThis highlight revisits rotenoid classification and provides a thorough understanding of how their occurrences could inform plant taxonomy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Vaderament-A. Nchiozem-Ngnitedem
- Streptomyces as a versatile host platform for heterologous production of microbial natural products September 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00036J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Constanze Lasch, Maksym Myronovskyi, Andriy LuzhetskyyThis review outlines recent strategies for genome mining, synthetic refactoring, and host-based expression of natural product biosynthetic gene clusters, focusing on discovery, dereplication, and scalable production.To cite […]Constanze Lasch
- Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) August 26, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00026B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maximilian Frey, Sandra T. Gohr, Tobias G. Köllner, Ulschan Bathe, Nathalie D. Lackus, Federico Padilla-Gonzalez, Dae-Kyun Ro, Sarah E. O'Connor, Jörg Degenhardt, Alain TissierThe mint family (Lamiaceae) produces a wide range of […]Maximilian Frey
- Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides July 15, 2025Nat. Prod. Rep., 2025, 42,1622-1638DOI: 10.1039/D5NP00042D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shumpei AsamizuThis highlight focuses on the recent advances in the discovery and biosynthesis of bioactive lipopeptide natural products derived from ribosomally synthesized and post-translationally modified peptides.The content of this RSS Feed (c) The […]Shumpei Asamizu
- Natural products targeting the metabolism of amino acids: from discovery to synthetic development July 10, 2025Nat. Prod. Rep., 2025, 42,1575-1621DOI: 10.1039/D5NP00039D, Review ArticleHyun Su Kim, Ahmed H. E. Hassan, Kyuho Moon, Jaehoon SimAmino acid metabolism is essential to homeostasis, immune regulation, and disease. This review highlights natural products that modulate these metabolic pathways and outlines synthetic strategies to enhance their therapeutic potential.The content of this RSS Feed (c) The Royal […]Hyun Su Kim
- Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications June 26, 2025Nat. Prod. Rep., 2025, 42,1489-1506DOI: 10.1039/D5NP00027K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D. Keasling, Byung-Kwan ChoSynthetic protein interfaces enable programmable assembly of PKS and […]Gahyeon Kim
- The ballet of nature: the interconvertible isomerisation of natural products June 22, 2025Nat. Prod. Rep., 2025, 42,1548-1574DOI: 10.1039/D5NP00019J, Review ArticleZe-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang LouThis review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers found in nature, including positional, tautomeric, geometric, optical, and conformational isomerism.The content of this RSS Feed (c) The Royal Society of ChemistryZe-Jun Xu
- Natural products in antiparasitic drug discovery: advances, opportunities and challenges June 11, 2025Nat. Prod. Rep., 2025, 42,1419-1458DOI: 10.1039/D5NP00007F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaofei Shang, Lixia Dai, Xinyuan Cao, Yudong Ma, Ilgekbayeva Gulnaz, Xiaolou Miao, Xiuhui Li, Xiaorong YangIn this review, we discuss the strategies used for developing drugs from natural resources and mainly describe the […]Xiaofei Shang
- Exploring microbial natural products through NMR-based metabolomics June 11, 2025Nat. Prod. Rep., 2025, 42,1459-1488DOI: 10.1039/D4NP00065J, Review ArticleDe-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng WuNMR-based metabolomics—whether applied independently or harmonized with genomics—offers a potent lens into microbes' chemical repertoire. The judicious integration of artificial intelligence (AI) further amplifies the potential of this advanced methodology, ushering in new frontiers for microbial natural […]De-Gao Wang
- Trends in metabolite discovery from Actinomycetes June 8, 2025Nat. Prod. Rep., 2025, 42,1533-1547DOI: 10.1039/D4NP00075G, Review ArticlePaolo Monciardini, Matteo Simone, Marianna Iorio, Sonia I. Maffioli, Margherita Sosio, Stefano DonadioActinomycetes continue to provide new molecules at a steady rate. Here we analyze the contribution of four approaches to the discovery of new metabolites, and which strategies are more effective at yielding structurally original molecules.The content […]Paolo Monciardini
- Technological developments driving industrial natural product discovery June 3, 2025Nat. Prod. Rep., 2025, 42,1507-1532DOI: 10.1039/D4NP00072B, Review ArticleRichard Lewis, Richard Hammond, Mark Wilkinson, Nick AllenbyA new era of antimicrobial discovery: reviewing the limits of traditional methods and the potential for new techniques to discover from previously inaccessible biosynthetic diversity.The content of this RSS Feed (c) The Royal Society of ChemistryRichard Lewis
- Scalability of mass spectrometry-based metabolomics for natural extracts libraries exploration: current status, challenges, and opportunities September 14, 2025
