Natural Product Reports

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    • Progress in the discovery and development of anticancer agents from marine cyanobacteria December 2, 2024
      Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00019F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hendrik Luesch, Emma K. Ellis, Qi-Yin Chen, Ranjala RatnayakeWe describe the pipeline of anticancer agents from marine cyanobacteria, highlighting critical steps from discovery towards development, including the identification of the molecular target […]
      Hendrik Luesch
    • Effective data visualization strategies in untargeted metabolomics December 2, 2024
      Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00039K, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kevin Mildau, Henry Ehlers, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber, Justin […]
      Kevin Mildau
    • Hot off the Press November 25, 2024
      Nat. Prod. Rep., 2024, 41,1819-1823DOI: 10.1039/D4NP90050B, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as dicitrinol A from Penicillium citrinum.The content of this RSS Feed (c) The Royal Society of Chemistry
      Robert A. Hill
    • Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides November 18, 2024
      Nat. Prod. Rep., 2024, 41,1835-1845DOI: 10.1039/D4NP00044G, HighlightFrancisca Vicente, Fernando Reyes, Olga GenilloudA highlight on the discovery of the antifungal enfumafungin, its biosynthesis, activity profile and mode of action that led to the development program of ibrexafungerp, the first oral antifungal agent approved in more than 20 years.The content of this RSS Feed (c) The Royal […]
      Francisca Vicente
    • Debottlenecking cytochrome P450-dependent metabolic pathways for the biosynthesis of commercial natural products November 18, 2024
      Nat. Prod. Rep., 2024, 41,1846-1857DOI: 10.1039/D4NP00027G, HighlightSusanne M. Germann, Maxence Holtz, Michael Krogh Jensen, Carlos G. Acevedo-RochaExploring metabolic and protein engineering solutions, this article discusses breakthroughs in enhancing cytochrome P450 performance, paving the way for more sustainable and efficient bioprocesses in natural product manufacturing.The content of this RSS Feed (c) The Royal Society of Chemistry
      Susanne M. Germann
    • Bi- and tricyclic diterpenoids: landmarks from a decade (2013–2023) in search of leads against infectious diseases October 6, 2024
      Nat. Prod. Rep., 2024, 41,1858-1894DOI: 10.1039/D4NP00021H, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Olha Antoniuk, Ana Maranha, Jorge A. R. Salvador, Nuno Empadinhas, Vânia M. MoreiraRelevant biological activities of both naturally occurring and semi-synthetic bi- and tricyclic diterpenoids, in the context of infection, are highlighted in […]
      Olha Antoniuk
    • Chemical case studies from natural products of recent interest in the crop protection industry September 18, 2024
      Nat. Prod. Rep., 2024, 41,1915-1938DOI: 10.1039/D4NP00035H, Review ArticleGeorg Späth, Olivier LoiseleurThrough the lens of chemical case studies, this review examines most recent and selected iconic natural product classes in crop protection.The content of this RSS Feed (c) The Royal Society of Chemistry
      Georg Späth
    • Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production September 15, 2024
      Nat. Prod. Rep., 2024, 41,1895-1914DOI: 10.1039/D4NP00024B, Review ArticleRichard H. BaltzComplex regulatory mechanisms govern daptomycin biosynthesis in Streptomyces roseosporus. Ten regulatory genes modulate transcription of daptomycin biosynthetic genes from a single promoter, and translation is coordinated by translational coupling.The content of this RSS Feed (c) The Royal Society of Chemistry
      Richard H. Baltz
    • Scaling up for success: from bioactive natural products to new medicines August 11, 2024
      Nat. Prod. Rep., 2024, 41,1824-1834DOI: 10.1039/D4NP00022F, ViewpointMaximilian J. Helf, Kathrin Buntin, Andrej Klančar, Michael Rust, Frank Petersen, Dominik Pistorius, Eric Weber, Joanne Wong, Philipp KrastelDiscovery and scalable production of natural product drugs require a combination of molecular biology, data science, chemistry and fermentation methods. Here, we describe our drug discovery toolbox and share our perspective […]
      Maximilian J. Helf