RSC – Nat. Prod. Rep. latest articles- Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides November 18, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00044G, HighlightFrancisca Vicente, Fernando Reyes, Olga GenilloudA highlight on the discovery of the antifungal enfumafungin, its biosynthesis, activity profile and mode of action that led to the development program of ibrexafungerp, the first oral antifungal agent approved in more than 20 years.To cite this article before page numbers are […]Francisca Vicente
- Debottlenecking cytochrome P450-dependent metabolic pathways for the biosynthesis of commercial natural products November 18, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00027G, HighlightSusanne M. Germann, Maxence Holtz, Michael Krogh Jensen, Carlos G. Acevedo-RochaExploring metabolic and protein engineering solutions, this article discusses breakthroughs in enhancing cytochrome P450 performance, paving the way for more sustainable and efficient bioprocesses in natural product manufacturing.To cite this article before page numbers are assigned, use the […]Susanne M. Germann
- The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture November 18, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00046C, Review ArticleRomain M. M. François, Jean-Malo Massicard, Kira J. WeissmanLarge-scale sequencing has revealed the widespread occurrence of type I polyketides in all kingdoms of life, while co-culturing methods coupled with biochemical analysis have started to tease out their diverse ecological and physiological roles.To cite this article before page […]Romain M. M. François
- Human microbiota peptides: important roles in human health November 15, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00042K, Review ArticleAbdul Bari Shah, Sang Hee ShimThis review highlights the functions of bioactive peptides derived from human microbiota in various health issues including antimicrobial defense and resistance, thereby facilitating the development of personalised healthcare strategies.To cite this article before page numbers are assigned, use the DOI form of […]Abdul Bari Shah
- Chemical diversity of cyanobacterial natural products November 14, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00040D, Review ArticleMárcio B. Weiss, Ricardo M. Borges, Peter Sullivan, João P. B. Domingues, Francisco H. S. da Silva, Victória G. S. Trindade, Shangwen Luo, Jimmy Orjala, Camila M. CrnkovicThis review article covers 995 natural products of cyanobacterial origin reported from 2010 to 2023. Compounds were analyzed using similarity […]Márcio B. Weiss
- Small animals with unique chemistry – the natural product chemistry of Collembola November 12, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00049H, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anton Möllerke, Stefan SchulzThe secondary metabolites of springtails (Collembola) include defensive compounds, cuticular lipids, and semiochemicals, many of which are not known from other natural sources. The springtail chemistry differs largely from that […]Anton Möllerke
- Siccanin-related drimane meroterpenoids: biological activities and synthesis November 4, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00025K, Review ArticleShengxin Sun, Xia Wang, Nvdan Hu, Shiqi Fu, Shengkun LiThis review describes the isolation, structural characteristics, bioactivities and divergent synthetic strategies of siccanin-related drimane meroterpenoids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Shengxin Sun
- Synthetic-bioinformatic natural product-inspired peptides October 30, 2024Nat. Prod. Rep., 2024, Advance ArticleDOI: 10.1039/D4NP00043A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Samantha Nelson, Elizabeth I. ParkinsonSynthetic-bioinformatic natural product inspired peptides (syn-BNPs) are predicted peptides from biosynthetic gene clusters that are synthetically accessed. This method enables easier access to natural product-like peptides for bioactivity […]Samantha Nelson
- Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids October 2, 2024Nat. Prod. Rep., 2024, 41,1787-1810DOI: 10.1039/D4NP00029C, Review ArticleYa Tian, Lingzhe Kong, Qi Li, Yifan Wang, Yongmiao Wang, Zhoujie An, Yuwei Ma, Lixia Tian, Baozhong Duan, Wei Sun, Ranran Gao, Shilin Chen, Zhichao XuThis review explores structures, classifications, and distributions of benzylisoquinoline alkaloids (BIAs) and summarizes their biosynthetic pathway, enzymatic catalysis, origin, evolution, and metabolic engineering.The […]Ya Tian
- Isolation, biological activity, and synthesis of isoquinoline alkaloids October 1, 2024Nat. Prod. Rep., 2024, 41,1652-1722DOI: 10.1039/D4NP00023D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaorong Yang, Xiaolou Miao, Lixia Dai, Xiao Guo, Janar Jenis, Jiyu Zhang, Xiaofei ShangIsoquinoline alkaloids are common throughout living organisms and exhibit widely bioactivitiesThe content of this RSS Feed (c) The Royal Society […]Xiaorong Yang
- Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products September 23, 2024Nat. Prod. Rep., 2024, 41,1630-1651DOI: 10.1039/D4NP00018H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuyang Wang, Yan-Ni Shi, Hao Xiang, Yi-Ming ShiThis review highlights the discovery of functional microbial natural products from diverse niches. Leveraging the biosynthetic capabilities of microbes in organismic interactions is crucial for tackling […]Yuyang Wang
- Current and emerging tools and strategies for the identification of bioactive natural products in complex mixtures September 17, 2024Nat. Prod. Rep., 2024, 41,1766-1786DOI: 10.1039/D4NP00006D, Review ArticleManon Meunier, Andreas Schinkovitz, Séverine DerbréThis review highlights the strengths and limitations of chemometric analyses as well as MS and/or NMR-based dereplication strategies used to achieve the highest level of confidence in annotating (bio)active NPs from complex matrices.The content of this RSS Feed (c) The Royal Society of […]Manon Meunier
- Structural diversity and chemical logic underlying the assembly of monoterpene indole alkaloids oligomers September 11, 2024Nat. Prod. Rep., 2024, 41,1723-1765DOI: 10.1039/D4NP00011K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pierre Le Pogam, Mehdi A. BeniddirThis review aims at drawing a parallel between all known monoterpene indole alkaloids oligomers by illustrating the chemical logic underlying their assembly.The content of this RSS Feed (c) […]Pierre Le Pogam
- Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides November 18, 2024
