RSC – Nat. Prod. Rep. latest articles- Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications May 19, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00018A, Review ArticleYanqing Xue, Yijiao Xiong, Wei Huang, Jianing Liu, Wen LiuPosttranslational modifications characterized over the past decade to engage the –(NH–Cα–CO)n– repeating units in transformations are highlighted, particularly those leading to structural rearrangements by peptide backbone remodeling.To cite this article before page numbers are assigned, use the DOI […]Yanqing Xue
- Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin May 15, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00012B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark Ellerhorst, Vadim Nikitushkin, Walid K. Al-Jammal, Lucas Gregor, Ivan Vilotijević, Gerald LacknerMycofactocin is a peptide-derived redox cofactor, commonly present in mycobacteria. This review covers its structural diversity, synthesis, biosynthesis and biochemical […]Mark Ellerhorst
- Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity May 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00011D, Review ArticleFan Zhang, Di Zhao, Yuzhu Wu, Lei LiThis review highlights the occurrence, structures, biosynthesis and bioactivities of prenylated bacterial natural products and outlines the mechanistic study of cluster-situated prenyltransferases for the development of novel biocatalysts.To cite this article before page numbers are assigned, use the DOI form […]Fan Zhang
- Recent highlights of the total synthesis of cyclic peptide natural products May 13, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00056K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Takayuki Doi, Masaya Kumashiro, Kosuke OhsawaThis review described the total synthesis of naturally occurring cyclic peptides covering 2020 to 2022 paying particular attention to the construction of their unique structures via macrocyclization.To […]Takayuki Doi
- Molecular insights fast-tracked: AI in biosynthetic pathway research March 25, 2025Nat. Prod. Rep., 2025, 42,911-936DOI: 10.1039/D4NP00003J, Review ArticleLijuan Liao, Mengjun Xie, Xiaoshan Zheng, Zhao Zhou, Zixin Deng, Jiangtao GaoThis review explores how AI addresses challenges in biosynthetic pathway research, accelerating the development of bioactive natural products for pharmacology, agriculture, and biotechnology.The content of this RSS Feed (c) The Royal Society of ChemistryLijuan Liao
- Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products March 20, 2025Nat. Prod. Rep., 2025, 42,876-910DOI: 10.1039/D4NP00069B, Review ArticlePavel Yu. Ushakov, Alexey Yu. SukhorukovOver the past 25 years, the isoxazoline route to aldols has proven to be a powerful synthetic tool. This review discusses more than 50 syntheses of natural products, including macrolides, alkaloids, terpenoids, pseudosugars, and sulfolipids.The content of this RSS Feed (c) The Royal […]Pavel Yu. Ushakov
- Privileged natural product compound classes for anti-inflammatory drug development March 11, 2025Nat. Prod. Rep., 2025, 42,856-875DOI: 10.1039/D4NP00066H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Malcolm Z. Y. Choo, Julian A. T. Chua, Sean X. Y. Lee, Yuet Ang, W. S. Fred Wong, Christina L. L. ChaiThis review highlights six privileged classes of natural products – coumarins, polyphenols, […]Malcolm Z. Y. Choo
- Enzymatic crosslinking of histidine side chains in peptide natural products March 3, 2025Nat. Prod. Rep., 2025, 42,763-773DOI: 10.1039/D5NP00001G, HighlightYing Shi, Yinzheng Xia, Weijiang Gao, Jingxue Wang, Bing Shi, Huan WangHistidine-containing crosslinks are important structural motifs found in natural cyclic peptides of both ribosomal and non-ribosomal origin. Their formation involves intricate enzymatic chemistry.The content of this RSS Feed (c) The Royal Society of ChemistryYing Shi
- Microbial dynamics and Pseudomonas natural product production in milk and dairy products March 3, 2025Nat. Prod. Rep., 2025, 42,842-855DOI: 10.1039/D4NP00074A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ina Wasmuth, Christina Warinner, Pierre StallforthThis review focuses on the role of microorganisms and their natural products in milk and dairy products.The content of this RSS Feed (c) The Royal Society of ChemistryIna Wasmuth
- Antarctic bacterial natural products: from genomic insights to drug discovery February 25, 2025Nat. Prod. Rep., 2025, 42,774-787DOI: 10.1039/D4NP00045E, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.William Medeiros, Stanislava Kralova, Valéria Oliveira, Nadine Ziemert, Ludek SehnalThe article highlights the available data on Antarctic bacteria, their biosynthetic potential, and the successful NP discoveries while addressing the challenges in NP research and […]William Medeiros
- The cytochalasans: potent fungal natural products with application from bench to bedside February 24, 2025Nat. Prod. Rep., 2025, 42,788-841DOI: 10.1039/D4NP00076E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mohamed A. Tammam, Florbela Pereira, Elizabeth Skellam, Stefan Bidula, A. Ganesan, Amr El-DemerdashCytochalasans are fungal natural products with diverse structures and biomedical potential. This review explores their diversity, biosynthesis, pharmacokinetics, drug-likeness, and therapeutic […]Mohamed A. Tammam
- Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications May 19, 2025
