RSC – Nat. Prod. Rep. latest articles- Charting the path for L-tyrosine derivatives: from engineering strategies to microbial cell factories March 24, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00091B, Review ArticleLi Zhou, Xulei Shi, Hui Jiang, Yuanyuan Xia, Haiquan Yang, Wei Shen, Yu Cao, Xianzhong ChenReview highlights cutting-edge advances in producing L-tyrosine derivatives via tyrosol, p-coumaric acid, and L-DOPA nodes in E. coli and yeast.To cite this article before page numbers are assigned, use the DOI form […]Li Zhou
- Glucose 6-phosphate: the diversity of C-methylation in sugar moieties within natural product biosynthesis March 16, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00071H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ziruo Zou, Michael MüllerDiverse methylation of sugar units by SAM-dependent C-methyltransferases in natural product biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Ziruo Zou
- Highlights of cyanobacterial metabolites reported between 2021–2024 March 16, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00076A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Simon Sieber, Elisabeth M.-L. JanssenThis review provides an overview of newly identified cyanobacterial metabolites from 2021 to 2024. The discovery of specific natural products is discussed.To cite this article before page numbers […]Simon Sieber
- Decision making by modular polyketide synthases and implications for genetic engineering March 13, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00010J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kira J. WeissmanThis review details the many choices underlying faithful biosynthesis of complex polyketides in bacteria, and highlights the implications for genetic engineering aiming to generate novel derivatives.To cite this article before […]Kira J. Weissman
- Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computational NMR method March 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00088B, HighlightSrinivas Beduru, Andrei G. KutateladzeThis Highlight article describes a personal selection of recent misassigned structures of NPs and their revision with the aid of DU8ML, an ML-augmented DFT method for fast and accurate calculations of NMR parameters, mostly covering 2018 to 2025.To cite this article before page numbers […]Srinivas Beduru
- Quinic acid as a chiron in total synthesis March 3, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00087D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manuel J. Verganista, Iago C. Vogel, Nuno R. CandeiasQuinic acid is a versatile chiral building block in asymmetric synthesis, enabling diverse natural products and bioactive compounds. This review highlights four decades of […]Manuel J. Verganista
- Synthetic biology for heterologous expression and engineering of fungal polyketide synthases March 2, 2026Nat. Prod. Rep., 2026, 43,401-414DOI: 10.1039/D5NP00020C, HighlightSidharth Jayachandran, Adrian Enrique Gadar-Lopez, Ling Chen, Kasper Krunderup Jakobsen, Coco Xie, Therese Horch, Jay D. Keasling, Pablo Cruz-MoralesPolyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products.The content of this RSS Feed (c) The Royal Society of ChemistrySidharth Jayachandran
- Editorial: Microbial host and metabolic engineering for natural product discovery and production February 16, 2026Nat. Prod. Rep., 2026, 43,279-280DOI: 10.1039/D6NP90006B, EditorialAlessandra S. Eustaquio, Eriko Takano, Tobias A. M. GulderAlessandra Eustaquio, Eriko Takano and Tobias Gulder introduce the Natural Product Reports themed issue on microbial host and metabolic engineering for natural product discovery and production.The content of this RSS Feed (c) The Royal Society of ChemistryAlessandra S. Eustaquio
- Correction: Progress in the discovery and development of anticancer agents from marine cyanobacteria February 9, 2026Nat. Prod. Rep., 2026, 43,391-392DOI: 10.1039/D6NP90002J, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hendrik Luesch, Emma K. Ellis, Qi-Yin Chen, Ranjala RatnayakeThe content of this RSS Feed (c) The Royal Society of ChemistryHendrik Luesch
- Hot off the Press February 9, 2026Nat. Prod. Rep., 2026, 43,281-285DOI: 10.1039/D6NP90001A, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as candindole A from Aspergillus candidus.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Trimeric natural products: structural diversity, biosynthesis, bioactivities and chemical synthesis January 22, 2026Nat. Prod. Rep., 2026, 43,462-496DOI: 10.1039/D5NP00065C, Review ArticleHidayat Hussain, Satyajit D. Sarker, Lutfun Nahar, Ishtiaq AhmedThis review highlights structural diversity, biosynthesis, biomimetic synthesis, and biological functions of trimeric natural products. These biosynthetic pathways could lead to the discovery of more bioactive trimers through (bio)synthesis.The content of this RSS Feed (c) The Royal Society of ChemistryHidayat Hussain
- Discovery, engineering, and applications of amino acid and peptide prenyltransferases January 2, 2026Nat. Prod. Rep., 2026, 43,415-426DOI: 10.1039/D5NP00075K, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Florian HubrichThis review highlights advances in the field of amino acid and peptide prenyltransferases, underscoring their value for chemoenzymatic peptide late-stage functionalization and drug development and showcasing their scope, promiscuity and engineering.The content of […]Florian Hubrich
- Biosynthesis of invertebrate-derived natural products: an uncharted territory December 22, 2025Nat. Prod. Rep., 2026, 43,547-575DOI: 10.1039/D5NP00056D, Review ArticleFeng Li, Chengyu Zhou, Yinhao Wang, Mengmeng Yu, Jianhua JuInvertebrates are a major source of natural products. Their significant biosynthetic potential, revealed by recent studies, is summarized in this review as a reference for future research.The content of this RSS Feed (c) The Royal Society of ChemistryFeng Li
- Microbial skeletal editing: hints for arene reconstruction from actinobacteria December 22, 2025Nat. Prod. Rep., 2026, 43,518-546DOI: 10.1039/D5NP00078E, Review ArticleViktoria A. Ikonnikova, Vera A. Alferova, Anastasiya Yu. Frolova, Mikhail S. Baranov, Andrey A. MikhaylovThis review surveys skeletal editing in actinobacteria, linking enzyme-driven diversification to modern synthetic analogues and outlining biomimetic strategies that translate natural logic into practical chemical tools.The content of this RSS Feed (c) The Royal […]Viktoria A. Ikonnikova
- From diet to defence: ingestion, sequestration, biotransformation, and therapeutic potential of natural products in nudibranch predator–prey interactions December 17, 2025Nat. Prod. Rep., 2026, 43,497-517DOI: 10.1039/D5NP00058K, Review ArticleLauren Gris, Michèle R. PrinsepThis review focuses on the chemoecological interactions reported between nudibranchs and their marine invertebrate prey, highlighting the ingestion, sequestration and biotransformation of diet-derived natural products and their bioactivities.The content of this RSS Feed (c) The Royal Society of ChemistryLauren Gris
- Halogenases and dehalogenases: mechanisms, engineering, and applications November 3, 2025Nat. Prod. Rep., 2026, 43,427-461DOI: 10.1039/D5NP00055F, Review ArticleJing Luo, Na Li, Jia Wang, Yaojie Gao, Hongzhi Tang, Linquan Bai, Sang Yup Lee, Yaojun TongHalogenases and dehalogenases are ubiquitous biocatalysts that mediate halogen incorporation and removal. Synthetic biology is reshaping their catalytic landscapes to unlock new functions and applications.The content of this RSS Feed (c) The […]Jing Luo
- Engineering microbiomes for natural product discovery and production September 23, 2025Nat. Prod. Rep., 2026, 43,301-312DOI: 10.1039/D5NP00038F, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francesco Del Carratore, Rainer BreitlingThe exciting advancements in multi-omics, genetic engineering and computational tools are paving the way for the engineering of synthetic communities for the discovery and production of natural products. Created in […]Francesco Del Carratore
- Streptomyces as a versatile host platform for heterologous production of microbial natural products September 8, 2025Nat. Prod. Rep., 2026, 43,371-390DOI: 10.1039/D5NP00036J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Constanze Lasch, Maksym Myronovskyi, Andriy LuzhetskyyThis review outlines recent strategies for genome mining, synthetic refactoring, and host-based expression of natural product biosynthetic gene clusters, focusing on discovery, dereplication, and scalable production.The content of […]Constanze Lasch
- The development of Burkholderia bacteria as heterologous hosts July 27, 2025Nat. Prod. Rep., 2026, 43,335-351DOI: 10.1039/D5NP00024F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stephanie C. Heard, Alessandra S. EustáquioWe review Burkholderia bacterial strains that have been tested as heterologous hosts and the natural products obtained. We also compare host characteristics and their stage of development.The content […]Stephanie C. Heard
- Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering July 27, 2025Nat. Prod. Rep., 2026, 43,352-370DOI: 10.1039/D5NP00041F, Review ArticleBiyan Chen, Emre F. Bülbül, SeoungGun Bang, Hannah A. Minas, Kenan A. J. BozhüyükThis review outlines integrated platforms combining genome mining, computational design, synthetic biology, and high-throughput screening to enable the programmable biosynthesis of tailor-made natural products.The content of this RSS Feed (c) The Royal Society of ChemistryBiyan Chen
- Charting the path for L-tyrosine derivatives: from engineering strategies to microbial cell factories March 24, 2026
