RSC – Mol. Omics latest articles- Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk Tháng 10 13, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00136F, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kieu T. T. Le, Nick Keur, Heleen Middelkamp, Thuy Linh Do, Albert van den Berg, Valeria Orlova, Leo A.B. Joosten, Mihai G. Netea, Cisca Wijmenga, Iris Jonkers, Sebo Withoff, Andries D. Van der […]Kieu T. T. Le
- An altered proteome in ovarian cancer stem-like cells: profiling of the mDivi-1 induced proteome and its clinical significance Tháng 10 7, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00098J, Research ArticleManita Raina, Tejan Lodhiya, Rahail Ashraf, Kalpana Tankay, Arunaja K., Raju Mukherjee, Sanjay KumarThe graphical abstract represents the altered proteome in 2D- and 3D-cultured ovarian cancer cells. mDivi-1-treated 3D-cultured cells have differential expression of proteins that correlate with progression-free survival of ovarian cancer patients.To cite this article before […]Manita Raina
- Multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking Tháng 9 30, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00151J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nicolas Borisov, Yaroslav Ilnytsky, Boseon Byeon, Olga Kovalchuk, Igor KovalchukThe main finding – the expression of long non-coding RNAs (in red) – correlates much better with mRNA, as compared to correlation between miRNA […]Nicolas Borisov
- MOFNet: a deep learning framework for multi-omics data fusion in cancer subtype classification Tháng 9 30, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00221D, Research ArticleGuangji Zhang, Chunxiao Zhang, Pengpai Li, Duanchen Sun, Zhixia Yang, Zhi-Ping LiuMOFNet integrates multi-omics data using similarity graph pooling and label-space fusion (VCDN), improving cancer subtype classification while retaining interpretable, biologically relevant features.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Guangji Zhang
- MALDI mass spectrometry imaging in plant and food lipidomics: advances, challenges, and future perspectives Tháng 9 25, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00116A, Review ArticleG. Ventura, M. Bianco, I. Losito, T. R. I. Cataldi, C. D. CalvanoMALDI MSI enables high-resolution spatial lipid analysis in plants and food. This review covers current methods, challenges, and emerging technologies shaping the future of plant and food lipidomics research.To cite this article before page numbers are […]G. Ventura
- Prunus mongolica oil attenuates hepatic fibrosis via a lncRNA-mediated ceRNA network targeting dual PGC-1α/PPARγ and TGF-β/Smad3 pathways Tháng 9 22, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00083A, Research ArticleYiJie Hou, HongBing Zhou, XiaoGang Li, JiaXing Gao, Hong Chang, Jia Wang, YingChun Bai, ShuYuan Jiang, ShuFang Niu, WanFu Bai, SongLi ShiThis study systematically investigated the antifibrotic mechanism of Prunus mongolica oil through an integrated approach combining pharmacodynamics, transcriptomics, and molecular biology in CCl4-induced Sprague–Dawley rat models.To cite […]YiJie Hou
- Network-driven identification of indisulam neo-substrates for targeted protein degradation Tháng 9 22, 2025Mol. Omics, 2025, Advance ArticleDOI: 10.1039/D5MO00053J, Research ArticleAndrew F. Jarnuczak, Orli Yogev, Angelo Andres, Stephanie K. Ashenden, Cheng Ye, Fiona Pachl, Andrew Zhang, Maria Emanuela Cuomo, Meizhong JinMolecular glue neo-substrate identification via proteomics profiling and network analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Andrew F. Jarnuczak
- Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in caveolin-1 null mice Tháng 9 9, 2025Mol. Omics, 2025, 21,512-523DOI: 10.1039/D5MO00059A, Research ArticleShankar P. Poudel, Maliha Islam, Thomas B. McFadden, Susanta K. BehuraMice lacking caveolin-1 (Cav1), a major protein of the lipid raft of plasma membrane, show deregulated metabolism of the mammary gland and an abnormal fetoplacental communication during pregnancy.The content of this RSS Feed (c) The Royal Society of ChemistryShankar P. Poudel
- Thioridazine induces phospholipid accumulation and necroptosis in parental and tamoxifen-resistant breast cancer cells Tháng 7 27, 2025Mol. Omics, 2025, 21,496-511DOI: 10.1039/D5MO00039D, Research ArticleChandrasekaran Mythri, Sachin B Jorvekar, Nirawane Suraj, Nethaji Pruthiviraj, Roshan M Borkar, Sudhagar SelvarajuThioridazine induces phospholipid accumulation and necroptosis in both parental and tamoxifen-resistant breast cancer cells, enhancing tamoxifen efficacy and showing promise as a repurposed treatment strategy.The content of this RSS Feed (c) The Royal Society of ChemistryChandrasekaran Mythri
- Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry Tháng 7 13, 2025Mol. Omics, 2025, 21,479-495DOI: 10.1039/D5MO00020C, Research ArticleAiswarya Suresh, Nikhil Pallaprolu, Aishwarya Dande, Harish Kumar Pogula, Vipan Kumar Parihar, Ramalingam PeramanProteomic profiling reveals storage temperature- and time-dependent degradation of tissue proteins, highlighting critical factors for sample preservation in mass spectrometry-based analyses.The content of this RSS Feed (c) The Royal Society of ChemistryAiswarya Suresh
- Understanding metabolic alterations in advanced stage chronic kidney disease patients by NMR-based metabolomics Tháng 6 15, 2025Mol. Omics, 2025, 21,464-478DOI: 10.1039/D5MO00019J, Research ArticleAmrita Sahu, Upasna Gupta, Bikash Baishya, Dharmendra Singh Bhadauria, Neeraj SinhaIllustrate NMR-based metabolomics identifies distinct metabolic alterations and disrupted pathways in advanced-stage CKD, offering improved diagnostic insight beyond creatinine-based methods.The content of this RSS Feed (c) The Royal Society of ChemistryAmrita Sahu
- POMC-specific modulation of metabolic and immune pathways via melanocortin-3 receptor signaling Tháng 6 10, 2025Mol. Omics, 2025, 21,456-463DOI: 10.1039/D4MO00248B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mariya Nezhyva, Friederike A. Sandbaumhüter, Per E. Andrén, Erik T. JanssonThis proteomic study provides a nuanced mechanistic understanding of the signaling processes upon agonist binding to the melanocortin-3 receptor (MC3R).The content of this RSS […]Mariya Nezhyva
- Advancing colorectal cancer research through lipidomics Tháng 6 3, 2025Mol. Omics, 2025, 21,373-389DOI: 10.1039/D5MO00045A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pedro Santiago, Tânia Melo, Maria Barceló-Nicolau, Gwendolyn Barceló-Coblijn, Pedro Domingues, Rosário DominguesLipidomic profiling of CRC plasma and tissue reveals alterations in lipid species, including from phospholipids, sphingolipids, and glycerolipids.The content of this RSS Feed […]Pedro Santiago
- Integrated multi-omic analyses of bovine milk identify biomarkers of negative energy balance Tháng 5 20, 2025Mol. Omics, 2025, 21,433-445DOI: 10.1039/D4MO00190G, Research ArticleA. Leduc, A. Rau, D. Laloë, S. Le Guillou, P. Martin, M. Gelé, J. Pires, Y. Faulconnier, C. Leroux, M. Boutinaud, F. Le ProvostAn integrative multi-omic study of bovine milk production and composition in two feed restriction trials to understand adaptations to negative energy balance and to develop non-invasive […]A. Leduc
- Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC Tháng 5 11, 2025Mol. Omics, 2025, 21,390-421DOI: 10.1039/D4MO00154K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patricia Pascual-Vargas, Mar Arias-Garcia, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Chris BakalDOCK5 acts at focal adhesions in breast cells to establish positive feedback loops via CDC42 and RAC The stabilisation of polarity during migration […]Patricia Pascual-Vargas
- Transcriptome and proteome analyses reveal the virulence of the Vibrio alginolyticus effector gene vopR Tháng 4 24, 2025Mol. Omics, 2025, 21,446-455DOI: 10.1039/D5MO00010F, Research ArticleFan Da, Shuanghu Cai, Liangliang Xu, Shixi Chen, Bin Li, Min TaoVibrio alginolyticus is an opportunistic infectious pathogen, and its pathogenicity is related to various virulence factors, with the type III secretion system (T3SS) being one of the important systems for secreting virulence factors.The content of this RSS Feed […]Fan Da
- Proteomic and metabolomic dissection of the BRAF V600E mutation-induced cellular state transition in lung epithelial cells Tháng 4 22, 2025Mol. Omics, 2025, 21,422-432DOI: 10.1039/D4MO00249K, Research ArticleFengting Liu, Fan Yang, Hailin Xiong, Jingnan Huang, Zhenhui Huang, Jingying Song, Xinyi Liu, Hongchao Zhou, Jing Xu, Jimin Yuan, Lin Jia, Lingyun DaiThis study established a BRAF V600E knock-in BEAS-2B cell model that allows us to systematically dissect the underlying molecular events involved in the cellular state transitions […]Fengting Liu
- Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk Tháng 10 13, 2025
