RSC – Nat. Prod. Rep. latest articles- The oxidative rearrangements in bacterial aromatic polyketide biosynthesis September 9, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00049A, Review ArticleFangwen Jiao, Shuai Li, Hongzhi Qiao, Ruihua JiaoIn this review article, we focus on the chemical and enzymatic mechanisms of carbon skeleton rearrangements in aromatic polyketide biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Fangwen Jiao
- Natural product-derived compounds in clinical trials and drug approvals September 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00031A, Review ArticleMark S. Butler, Robert J. Capon, Mark A. T. Blaskovich, Ian R. HendersonNatural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine.To cite this article before page numbers are assigned, use the DOI form […]Mark S. Butler
- Rotenoid diversity, distribution and evolution in plant lineages September 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00054H, HighlightVaderament-A. Nchiozem-Ngnitedem, Alan Paton, Gabin Thierry M. BitchagnoThis highlight revisits rotenoid classification and provides a thorough understanding of how their occurrences could inform plant taxonomy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Vaderament-A. Nchiozem-Ngnitedem
- Streptomyces as a versatile host platform for heterologous production of microbial natural products September 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00036J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Constanze Lasch, Maksym Myronovskyi, Andriy LuzhetskyyThis review outlines recent strategies for genome mining, synthetic refactoring, and host-based expression of natural product biosynthetic gene clusters, focusing on discovery, dereplication, and scalable production.To cite […]Constanze Lasch
- Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) August 26, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00026B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maximilian Frey, Sandra T. Gohr, Tobias G. Köllner, Ulschan Bathe, Nathalie D. Lackus, Federico Padilla-Gonzalez, Dae-Kyun Ro, Sarah E. O'Connor, Jörg Degenhardt, Alain TissierThe mint family (Lamiaceae) produces a wide range of […]Maximilian Frey
- Natural products influence bacteriophage infectivity August 17, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00014A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zhiyu Zang, Joseph P. GerdtThis review comprehensively reports historical and recent examples of natural products that either prevent bacteriophages from infecting bacteria, promote those infections, or regulate the induction of the lytic […]Zhiyu Zang
- Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis August 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00032G, Review ArticleYujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan ZhangThis review covers natural polycyclic aromatic hydrocarbons with more than two fused rings conforming to Hückel's rule. The comprehensive summary includes their structural classification, bioactivity, biosynthesis, and chemical synthetic studies.To cite this […]Yujian Mao
- Hot off the Press July 30, 2025Nat. Prod. Rep., 2025, 42,1235-1239DOI: 10.1039/D5NP90029H, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hypbeaone A from Hypericum beanii.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- The chemical and biological properties of natural resorcylic acid lactones June 18, 2025Nat. Prod. Rep., 2025, 42,1387-1410DOI: 10.1039/D5NP00033E, Review ArticleYing Gao, Wanpeng Li, Hanli RuanThis review highlights the classification, structures, origins, biotargets, and clinical studies of naturally derived resorcylic acid lactones, a valuable polyketide template for drug discovery.The content of this RSS Feed (c) The Royal Society of ChemistryYing Gao
- Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids June 9, 2025Nat. Prod. Rep., 2025, 42,1251-1264DOI: 10.1039/D5NP00025D, HighlightChungwoo Lee, Sunkyu HanThis Highlight reviews the discovery, structure elucidation, (bio)synthesis, and applications of securingines A–I, highly oxidized securinega alkaloids with unique structures.The content of this RSS Feed (c) The Royal Society of ChemistryChungwoo Lee
- Advances in the discovery and study of Trichoderma natural products for biological control applications June 5, 2025Nat. Prod. Rep., 2025, 42,1367-1386DOI: 10.1039/D5NP00017C, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sophie Jin, Fabrizio AlbertiTrichoderma spp. are talented producers of bioactive natural products, with applications in crop protection and growth promotion. We describe methods for the discovery of these compounds focused mainly on cultivation, […]Sophie Jin
- Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications May 19, 2025Nat. Prod. Rep., 2025, 42,1276-1302DOI: 10.1039/D5NP00018A, Review ArticleYanqing Xue, Yijiao Xiong, Wei Huang, Jianing Liu, Wen LiuPosttranslational modifications characterized over the past decade to engage the –(NH–Cα–CO)n– repeating units in transformations are highlighted, particularly those leading to structural rearrangements by peptide backbone remodeling.The content of this RSS Feed (c) The Royal Society of ChemistryYanqing Xue
- Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin May 15, 2025Nat. Prod. Rep., 2025, 42,1344-1366DOI: 10.1039/D5NP00012B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark Ellerhorst, Vadim Nikitushkin, Walid K. Al-Jammal, Lucas Gregor, Ivan Vilotijević, Gerald LacknerMycofactocin is a peptide-derived redox cofactor, commonly present in mycobacteria. This review covers its structural diversity, synthesis, biosynthesis and biochemical functions. […]Mark Ellerhorst
- Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity May 14, 2025Nat. Prod. Rep., 2025, 42,1303-1343DOI: 10.1039/D5NP00011D, Review ArticleFan Zhang, Di Zhao, Yuzhu Wu, Lei LiThis review highlights the occurrence, structures, biosynthesis and bioactivities of prenylated bacterial natural products and outlines the mechanistic study of cluster-situated prenyltransferases for the development of novel biocatalysts.The content of this RSS Feed (c) The Royal Society of ChemistryFan Zhang
- Recent highlights of the total synthesis of cyclic peptide natural products May 13, 2025Nat. Prod. Rep., 2025, 42,1265-1275DOI: 10.1039/D4NP00056K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Takayuki Doi, Masaya Kumashiro, Kosuke OhsawaThis review described the total synthesis of naturally occurring cyclic peptides covering 2020 to 2022 paying particular attention to the construction of their unique structures via macrocyclization.The content […]Takayuki Doi
- Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products April 15, 2025Nat. Prod. Rep., 2025, 42,1240-1250DOI: 10.1039/D5NP00009B, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Manyun Chen, Dipesh Dhakal, Campbell W. Eckhardt, Hendrik Luesch, Yousong DingWe focus on recent advances in synthetic biology strategies for the heterologous production of cyanobacterial natural products in cyanobacterial hosts, showcasing key examples across […]Manyun Chen
- The oxidative rearrangements in bacterial aromatic polyketide biosynthesis September 9, 2025
