RSC – Nat. Prod. Rep. latest articles- Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids May 11, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00089K, Review ArticleLanyu Zhou, Haiyue Gong, Huan Zhao, Luqi Huang, Yating HuThis review analyzes advances in plant alkaloid biosynthesis (2018–2025), highlighting key challenges in stereochemical control, cyclization, and tailoring modifications, and discusses synthetic biology strategies for microbial production.To cite this article before page numbers are assigned, use the DOI […]Lanyu Zhou
- Chemical language models for natural product discovery May 11, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00002A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Koh Sakano, Kairi Furui, Apakorn Kengkanna, Yuta Kikuchi, Masahito OhueNatural products are an important source of medicines, yet their discovery can be a slow and laborious process.To cite this article before page […]Koh Sakano
- Structural determination of natural products at speeds and scale of high-throughput screening May 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00016A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Christopher C. Thornburg, Rohitesh Kumar, Dongdong Wang, Barry R. O'Keefe, Tanja GrkovicThis review highlights analytical techniques and methods used for the structural elucidation of natural products in high-throughput screening campaigns.To cite this […]Christopher C. Thornburg
- High-throughput assays for SAM-dependent methyltransferases: advances, challenges, and future perspectives May 4, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00006A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Renia Fotiadou, Florian Heinz, Konstantin F. G. Weigmann, Mark Doerr, Uwe T. Bornscheuer, Ioannis V. PavlidisHigh-throughput assays for SAM-dependent methyltransferases are useful tools for protein engineering efforts and beyond; advances, limitations, and […]Renia Fotiadou
- Advancing natural product R&D&I: guide for compliance with responsible research and innovation, ethics, Nagoya and Cartagena Protocols, and intellectual property protection April 30, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00072F, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Susana P. Gaudêncio, Belma Kalamujić Stroil, Lucie Novoveska, Céline Rebours, Xenia T. SchneiderRRI, ethical standards, the Nagoya and Cartagena Protocols, and IP frameworks influence natural products R&D&I and the bioeconomy, providing a […]Susana P. Gaudêncio
- Skeleton innovation versus structural diversification in terpenoid discovery: chemoinformatic insights from TeroKit April 30, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00004E, HighlightTao Zeng, Jiahao Li, Ruibo WuContrasting skeletal exploration with structural exploitation reveals a clear reality: terpenoid discovery in the past six years is overwhelmingly dominated by the modification-driven exploitation of established skeletons.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Tao Zeng
- β-Lactam antibiotics and β-lactamases: historical perspectives and a review of β-lactamase inhibitors derived from natural products April 22, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00081E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Phanankosi Moyo, Ikhane O. Albert, Neo Hlungwani, Thulani Sibanda, Perfoy Lumu, Ndivhuwo Kevin Khorommbi, Gurleen Kaur, Karina Calvopina Tapia, George Siegwart, Nana Kwaku Buabeng, Cynthia A. Danquah, Lyndy J. McGaw, Sekelwa Cosa, […]Phanankosi Moyo
- A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products April 20, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00090D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maria Michela Salvatore, Marco Masi, Marina DellaGreca, Anna AndolfiLasiodiplodia is a prominent genus within the Botryosphaeriaceae family which is known as a plant pathogen. Species of Lasiodiplodia are prolific sources of bioactive […]Maria Michela Salvatore
- Hot off the Press April 15, 2026Nat. Prod. Rep., 2026, 43,585-589DOI: 10.1039/D6NP90014C, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as spectaterpenoid A from Aspergillus spectabilis.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Microbial natural products activated by plant stress February 2, 2026Nat. Prod. Rep., 2026, 43,590-596DOI: 10.1039/D5NP00062A, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Barbara I. AdaikpohHighlighting studies that link plant stress to the activation of antimicrobial biosynthetic gene clusters in beneficial microbes, thereby illustrating chemical interactions in the plant's microenvironment that can inform natural product discovery.The content […]Barbara I. Adaikpoh
- Structure, bioactivity, biosynthesis, and synthesis of corynanthe alkaloids January 26, 2026Nat. Prod. Rep., 2026, 43,746-778DOI: 10.1039/D5NP00051C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chenxu Liu, Mengqi Tong, Kouharu Otsuki, Wei Li, Feng Feng, Jie ZhangThis paper reviews the structure, biosynthesis, synthesis, and activity of corynanthe alkaloids with the aim of providing new perspectives and discoveries for […]Chenxu Liu
- Microbe-derived aromatic polyketides toward MRSA infection: current advances and perspectives January 23, 2026Nat. Prod. Rep., 2026, 43,718-745DOI: 10.1039/D5NP00061K, Review ArticleFangfang Duan, Jiaying Lai, Linjie Wei, Siran Li, Polina Lopukhina, Zihuan Sang, Chen Chen, Xiaoyi Wei, Hongxin Liu, Haibo TanMethicillin-resistant Staphylococcus aureus (MRSA), one of the most common multidrug-resistant (MDR) bacterial strains, has severely threatened global healthcare for decades due to its high morbidity and mortality rates.The content […]Fangfang Duan
- Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects January 22, 2026Nat. Prod. Rep., 2026, 43,685-717DOI: 10.1039/D5NP00074B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdul Bari Shah, Young Jun Kim, Kyeong Seon Lee, Sang Hoon Han, Youngjoo Byun, Ki Yong LeeThe increasing prevalence of allergic diseases and immunological disorders is a significant public health issue requiring the […]Abdul Bari Shah
- Green gold of the Pacific: unlocking compounds from terrestrial flora for antitumor and immunomodulatory drug discovery January 5, 2026Nat. Prod. Rep., 2026, 43,627-649DOI: 10.1039/D5NP00073D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Paul Huchedé, Vincent Dumontet, Mariko MatsuiThis review highlights the Pacific region's terrestrial flora and explores its natural products as a source of novel antitumor and immunomodulatory compounds for drug discovery.The content of this […]Paul Huchedé
- Discovery, bioactivities and biosynthesis of spirooxindole alkaloids January 5, 2026Nat. Prod. Rep., 2026, 43,650-684DOI: 10.1039/D5NP00046G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang, Changsheng Zhang, Yiguang ZhuThis review provides a comprehensive summary of the origin, activities, and biosynthesis of spirooxindole-containing alkaloids derived from a […]Ruijie Chen
- A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids October 14, 2025Nat. Prod. Rep., 2026, 43,597-626DOI: 10.1039/D5NP00053J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marcel Kulike-Koczula, Dominik Heimann, Tobias Eulberg, Daniel Kohnhäuser, Roderich D. Süssmuth, Mark BrönstrupThis article summarizes insights on a new class of antibiotics defined by albicidins and cystobactamids. It presents their biosynthesis, total synthesis […]Marcel Kulike-Koczula
- Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids May 11, 2026
