RSC – Chem. Sci. latest articles- A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides March 29, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08821F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lylia Azzoug, Ana Novak, Hervé Meudal, Jean-Baptiste Madinier, Stéphane Charpentier, Karine Loth, Séverine Morisset-Lopez, Carlo Pifferi, Vincent AucagneGeneration of specific antibodies against peptides by immunization requires their covalent conjugation to protein carriers to […]Lylia Azzoug
- Spin Effect Regulation as A Design Principle for M-N-C Catalysts for Oxygen Electrocatalysis March 29, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00439C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Haiyan Li, Zhanzhao Fu, Yuan Yuan, Di Zhang, Yubo Chen, Hao Li, Ang CaoRecent advances indicate that regulating the spin state of metal centers can markedly modulate catalytic performance, motivating interest in exploiting […]Haiyan Li
- Nickel-catalyzed hydroxymethylation with α-silicon N-methoxyphthalimides via radical Brook rearrangement March 29, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC00986G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiao-Bo Liu, Muhammad Bilal, Jiaying Zuo, Ya-Xin Yu, Yu-Juan Wu, Boming Shen, Peng-Hui Shen, Hua-Jian Xu, Yu-Feng LiangNickel-catalyzed reductive hydroxymethylation of aryl electrophiles with α-silicon N-methoxyphthalimides via a radical Brook rearrangement enables late-stage, […]Xiao-Bo Liu
- Atomic-Level Engineering of Single-Atom Catalysts for Selective C-C Coupling in CO2 Hydrogenation to Ethanol March 28, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01691J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wenyu Zhen, Yiming Liu, Xiaohai Zhang, Shengjie Bai, Aobing Li, Kelun Jiang, Feng Wang, Ya Liu, Yubin Chen, Shaohua ShenThe selective hydrogenation of CO2 to ethanol represents a pivotal route for sustainable carbon […]Wenyu Zhen
- Constrained shadow tomography for molecular simulation on quantum devices March 27, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC09162D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Irma Avdic, Yuchen Wang, Michael Rose, Lillian I. Payne Torres, Anna O. Schouten, Kevin J. Sung, David A. MazziottiQuantum state tomography is a fundamental task in quantum information science, enabling detailed characterization of […]Irma Avdic
- Recent Advances of MOF-based single-atom photocatalysts for CO2 to solar fuels conversion under sunlight irradiation March 27, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00691D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adnan Majeed, Minh-Khoa Duong, Van-Duc Nguyen, Trong-On DoSolar-driven photocatalytic CO2 conversion offers a sustainable route to address energy demand and carbon emissions. Metal-organic frameworks (MOFs) have emerged as promising photocatalyst platforms due to […]Adnan Majeed
- Change of the aromatic nature through face-to-face stacking March 27, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC10179D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qian Wang, Rinat Nasibullin, Dage SundholmWe have computationally studied the aromatic nature of molecules built from tetraoxa-isophlorin (TOI) and Ni(II)-norcorrole (NiNc) moieties. Calculations of the magnetically induced current density (MICD) susceptibility and magnetically […]Qian Wang
- Ultrasmooth and Thin Pheomelanin-like Film as a Metal-Free Electrocatalytic Enhancer March 27, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00776G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chan Yeon Kim, Jae Ryeol Jeong, Seong Ah Jo, Jun Seok Park, Joowon choi, Myung Jun Kim, Minho Kim, Kyungtae Kang, Min Hyung LeeThis study explores a bioinspired approach to enhance electrocatalytic oxygen […]Chan Yeon Kim
- Mixed-Valence Ru Nanoparticles Anchored on N-rich Metal-Phthalocyanine/Graphene vdW Heterostructures for Hydrogen-Bond-Assisted Alkaline Hydrogen Evolution March 27, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00386A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zichong Xiang, Guanping Wei, Aifeng Yang, Shangyu Li, Sitian Xu, Yuelong Zhou, Longbin Li, Yiwang ChenHydrogen production via alkaline anion-exchange membrane H2O electrolysis (AEMWE) is constrained by sluggish hydrogen evolution reaction (HER) kinetics […]Zichong Xiang
- Geometric Orthogonality as a Recipe for Efficient Intramolecular Charge Generation in Core Substituted NDI Derivatives March 27, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00456C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hugh C. Britton, Alberto Martin Santa Daria, Chao Lyu, Andras B. Augusztin, Lewis Cowen, Dejan-Kresimir Bucar, Alethea B Tabor, Bob C. Schroeder, Sandra Gómez, Jose Marin Marin-BeloquiOne of the primary drawbacks of organic […]Hugh C. Britton
- Light-emitting polymer semiconductors in flexible electronics: strategies, challenges and future perspective March 27, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC00449K, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiang An, Wenyu Chen, Zhiyang Sun, Hong Ren, Xiao Luan, Shigang He, Man Xu, Jinyi Lin, Wei HuangThis perspective article reviews strategies—intrinsic flexibility engineering, external plasticization, and elastomer blending—to overcome the stretchability-optoelectronic trade-off in […]Xiang An
- Asymmetric Hydrogenation of 3H-Azepines via Catalytic Kinetic Resolution: Access to anti-Disubstituted Azepanes March 27, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01819J, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Linda Bui, Dilara Berna Yildiz, Diego García Matesanz, Esteban Matador, Raquel Sanchez, Iuliana Atodiresei, Giovanni Lonardi, Daniele LeonoriAzepanes are increasingly valued scaffolds in drug discovery, yet general asymmetric methods for their synthesis remain […]Linda Bui
- Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor March 26, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01693F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Cristina Misuraca, Christopher A. HunterWhen a phosphoryl oxygen interacts with two H-bond donors, the strength of the second H-bonding interaction much weaker than the first interaction, due to electrostatic repulsion between the […]Maria Cristina Misuraca
- Time-Resolved Tracking of Hot Carrier Relaxation in Two Types of MBenes March 26, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC06945A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jie Zhao, Qi Zhang, Pan Xiong, Chunli Wang, Liangzhu Zhang, Jiebo Li, Kun Zhao, Ruifeng Lu, Kaijun Yuan, Xueming YangIn metallic low-dimensional materials, the interaction between non-equilibrium electrons and phonons underlies various physical […]Jie Zhao
- Spatially Directed Charge Transfer in a Polymer Framework for Efficient Photocatalytic Overall Water Splitting March 26, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00631K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xinyu Meng, Jinjin Li, Peng Liu, tingwei wang, Ming Pan, Chih-Chun Ching, Yu-Long Men, Xizhong Chen, Yin-Ning Zhou, Yun-Xiang PanSolar-driven photocatalytic overall water (H2O) splitting (OWS) offers a sustainable route for hydrogen (H2) […]Xinyu Meng
- Large-scale protein conformational transitions revealed by weighted ensemble simulations and EPR March 26, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08971A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shramana Palit, Darian Yang, Xiaowei Bogetti, Anthony Bogetti, Olivia Wood, Sunil Saxena, Lillian ChongLarge-amplitude protein conformational changes are essential for cellular processes. Electron paramagnetic resonance (EPR) spectroscopy can detect such conformational changes by […]Shramana Palit
- Dock & Design: Engineering specificity for alternative pimaradiene outcome with the ent-kaurene synthase from Bradyrhizobium japonicum March 26, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09199C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mark Schmidt-Dannert, Yue Zhang, Liang Jin, Qiang Wang, Samuel Tufts, Meirong Jia, Dean J Tantillo, Justin B Siegel, Reuben J. PetersThe complexity of the reactions catalyzed by terpene synthases has hindered enzymatic engineering. […]Mark Schmidt-Dannert
- Porous organic polymers based on carbon–carbon coupling reaction: synthesis and applications March 25, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01090C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yifan Li, Jingyuan Zhao, Dongtao Liu, Guangshan ZhuThis review systematically summarizes various methods for constructing porous organic polymers (POPs) via carbon–carbon coupling reactions, and elaborates on their application scenarios and core advantages in […]Yifan Li
- A Thermochromic Polyoxovanadate with a 200,000-fold Conductivity Gain for Boosting Zinc-Ion Batteries Performance March 25, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01000H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ze-Xun Zhang, Xiao-Yue Zhang, Ping-Wei Cai, Shou-Tian Zheng, Cai SunThe performance of zinc-ion batteries is hampered by the cathode’s limited Zn2+ intercalation capacity and sluggish kinetics. Herein, we propose, for the first time, […]Ze-Xun Zhang
- Unlocking azobenzene isomerization mechanisms via an LLM agent-driven workflow integrating simulation, experiment, and machine learning March 25, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC08794E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yixi Shen, Ledu Wang, Yan Huang, Xiaolong Zhang, Meng Huang, Huirong Li, Jing He, Aoran Cai, Yang Wang, Pieter E. S. Smith, Jun Jiang, Zhuoying Zhu, Linjiang ChenLLM agent orchestration links theoretical simulation, […]Yixi Shen
- A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides March 29, 2026
