RSC – Chem. Sci. latest articles- Modulation of Nanoscale Sinuosity in Asymmetric Nano-Channel for High-Resolution Separation of Trace Xylene Isomer Impurities December 29, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC07611K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ming Xu, Xiao-Yi Fu, Sha-Sha Meng, Shu-Rui Gao, Yu Wang, Zhi-Yuan GuThe purification of para-xylene (pX) to ultra-high levels is critical for producing high-performance polyethylene terephthalate, yet trace-level quantification of its isomeric impurities, […]Ming Xu
- Spatial Pinning of Globally Inert Pores in Superhydrophobic Hydrogen-Bonded Organic Framework for Inverse Ethane/Ethylene Separation December 29, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08507A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Youlie Cai, Jing-Hong Li, Xiaoyan Xiao, Runzhi Wei, Rui-Biao Lin, Banglin Chen, Junkuo GaoOvercoming the intrinsic polarity of hydrogen bonds to construct a C2H6-affinitive nonpolar pore environment using an entirely pore-oriented π-conjugated core […]Youlie Cai
- Ag-triggered Co 4+ active sites enable OH* nucleophilic attack for efficient electrocatalytic alcohols to acids December 26, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09305H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yu-Wei Du, Jian-Yu Zhang, Hao-Jun Luo, You Zhang, Zhao-Qing Liu, Xi-Ting Zhang, Ting OuyangSelective oxidation of primary alcohols to carboxylic acids is widely employed transformation in organic chemistry. However, the intrinsic mechanism by […]Yu-Wei Du
- Multidimensional Kinetic Study on the Organocatalyzed Ring-Opening Polymerization (ROP) of L-lactide via a Robotic High-Throughput Flow Platform December 26, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC03998C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bo Zhang, Tanja JunkersRing-opening polymerization (ROP) of L-lactide catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was efficiently screened via a programmable high-throughput robotic flow platform with very high accuracy (absolute error < 4%). With a very...The […]Bo Zhang
- Improving the conjugation of organic ligands enhances the antenna effect and promotes the luminescence and optical imaging of chiral mononuclear Eu(III) complexes December 26, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09594H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ru-Yan Li, Meng-Juan Tang, Yun-Lan Li, Fan Yang, Hua-Hong Zou, Hai-Ling Wang, Zhong-Hong ZhuRegulating the conjugated structure of organic ligands to enhance the molar absorption coefficient can effectively promote the energy transfer process […]Ru-Yan Li
- CBL ubiquitin ligase targets translation as a degrader E3 December 26, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC06141E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alice T Wicks, Lori Sonia Buetow, Toshiyasu Suzuki, Tobias Schmidt, Sergio Lilla, Abigail Macmillan-Jones, Jennifer Turney, Andrea Gohlke, Martin Bushell, Andreas K Hock, Danny T HuangProteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that […]Alice T Wicks
- Beyond Active Sites: Interfacial Water Engineering with Single-Atom Ni-WCx for Concurrent Energy Storage and Biomass Conversion December 26, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09133K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaoyang He, Dengke Xiong, Kaiyan Zhang, Wei Wang, Shujie Xue, Jianying Wang, Deli Wu, Zuofeng ChenCoupling biomass valorization with rechargeable metal-air batteries offers a promising strategy to address energy storage and sustainable synthesis […]Xiaoyang He
- Chemoselectivity in the Cationic Phospha-Wittig reaction: Accessing Phosphorus-Heterocycles, Phosphaalkenes, and their annulated [4+2] Dimers December 26, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08693K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Philipp Royla, Kai Schwedtmann, Rosa Maria Gomila, Antonio Frontera, Jan J. WeigandTriflate salts of phosphito-phosphanides [LCP–P(OR)₃]⁺ (1[OTf], R = alkyl, LC = N-heterocyclic carbene) were obtained via nucleophilic fragmentation of the tetraphosphetane [(LC)4P4][OTf]4 […]Philipp Royla
- Halogen bonding-induced 1,3-carbohydroxylation of allyl carboxylates via 1,2-cationic acyloxy migration (1,2-CAM) December 24, 2025Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC08514D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sahil Sharma, Gaoyuan Zhao, Loay Bedda, Arman Khosravi, Djamaladdin G. Musaev, Ming-Yu NgaiHalogen-bond-assisted visible-light activation of alkyl iodide C–I bonds by H2O initiates a radical–cationic cascade that converts allyl carboxylates into β-acyloxy alcohols […]Sahil Sharma
- Unusual nitrene reactivity: imine formation in the photochemical reaction of a borylnitrene with ethene December 24, 2025Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC07994B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Virinder Bhagat, Holger F. BettingerCatecholato borylnitrene reacts with ethene to produce aziridine and an unexpected isomeric imine, formed via a singlet 1,3-diradical pathway revealed under cryogenic matrix conditions.To cite this article before page […]Virinder Bhagat
- Heteroaryl iminothioindoxyl (HA-ITI) photoswitches via regioselective aza-Wittig synthesis: unifying red-shifted absorption, large E/Z band separation, and tunable thermal recovery December 24, 2025Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC08074F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jialei Chen-Wu, Carlos Benitez-Martin, José A. González-Delgado, Flip de Jong, Eduard Fron, Gert Steurs, Antonio J. Martínez-Martínez, Francisco Nájera, Morten Grøtli, Johan Hofkens, Joakim Andréasson, Uwe PischelSubstitution of the iminothioindoxyl core with heteroaryl […]Jialei Chen-Wu
- Chemically-informed active learning enables data-efficient multi-objective optimization of self-healing polyurethanes December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC07752D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kang Liang, Xinke Qi, Xu Xiao, Li Wang, Jinglai ZhangSelf-healing polyurethanes (PUs) exhibit an inherent trade-off between mechanical strength and self-healing efficiency. Although optimizing the feed ratio can address the above limitations, identifying […]Kang Liang
- A Donor-Acceptor Photosensitizer-catalyst Dyad for Light-Driven Nicotinamide Hydrogenation December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08675B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander Tombrink, Mohini Semwal, Tamar Maisuradze, Alexander Klaus Mengele, Daniel Straub, Alexander Kuehne, Sven Rau, Stephan Kupfer, Benjamin Dietzek-Ivanšić, Birgit EsserUsing light energy to drive chemical transformations is of great relevance, with nature’s […]Alexander Tombrink
- Structure-Activity-Relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC04919A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Harold Grosjean, Kate K Fieseler, Ruben Sanchez-Garcia, Warren Athol Thompson, Charlotte Mary Deane, Frank von Delft, Philip BigginFragment-based drug design offers multiple routes to advance from fragments. One approach is to build structure-activity […]Harold Grosjean
- Electrolyte Coordination Environments in Wide-Temperature Aqueous Metal Batteries: Mechanisms and Design Strategies December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08605A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiashuo Zhang, Tao Liu, Xusheng Dong, Zhongju Chen, Bin Tang, Fanxing Bu, Hong-Peng Li, Zhen Zhou, Dongliang Chao, Ruizheng ZhaoAqueous metal batteries (AMBs) are promising for energy storage attributed to intrinsic safety, low […]Jiashuo Zhang
- Confining chromophores by polymer conformation rigidification for room-temperature phosphorescence hydrogels December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08423G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.weihao feng, Muqing Si, Kuangzheng Cao, Wei Lu, Xiaoye Zhang, Tao ChenOrganic room-temperature phosphorescent (RTP) materials have played an important role in many emerging photonic applications, such as flexible electronics, bioimaging, and information […]weihao feng
- Metal-Free Radical Borylations: Mechanisms, Catalytic Strategies, and Synthetic Applications December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08322B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ziyi Quan, Yaxu Liu, Qidi Zhong, Bo WangMetal-free radical borylation has emerged as a powerful and sustainable alternative to transition-metal-catalyzed methods, addressing challenges such as residual metal contamination, functional group sensitivity, and the […]Ziyi Quan
- Robust Janus-Faced Quasi-Solid-State Electrolytes Mimicking Honeycomb for Fast Transport and Adequate Supply of Sodium Ions December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08536E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Fang Chen, Yadan Xie, Zhoubin Yu, Na Li, Xiang Ding, Yu QiaoQuasi-solid-state electrolytes are one of the most promising alternative candidate for traditional liquid state electrolytes with fast ion transport rate, high mechanical […]Fang Chen
- DSSA-PPI: Enhancing binding affinity change prediction upon protein mutations using disentangled structure-sequence aware attention December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08898D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.juhong Wu, Jiehui Sun, Tian Liang, Yongqi Zhang, Han Zhang, Tianyi Zhang, Xianmin Feng, Ping Gao, Peng Xu, Jinyu LiAccurate assessment of the effects of mutations on protein-protein interactions (PPIs) is crucial for […]juhong Wu
- Tripartite Hydrogen-Bonding as a Driving Force for High-Concentration Cyclization of Poly(L-lactide) December 23, 2025Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC08070C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sébastien Moins, Alexandre Mignot, Céline Henoumont, Sophie Laurent, Philippe Leclere, Olivier CoulembierA three-step strategy enables efficient cyclization of high-Mn PLLA at 0.5 M. Key to success is a persistent tripartite complex driven by […]Sébastien Moins
- Modulation of Nanoscale Sinuosity in Asymmetric Nano-Channel for High-Resolution Separation of Trace Xylene Isomer Impurities December 29, 2025
