RSC – Chem. Sci. latest articles- Palladium-Catalyzed Redox Diversified Entry to Axially Chiral Styrenes via Asymmetric Olefination with Alkynes July 3, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC04080A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xingwei Li, Yuqing Jiang, Jessica Li, Zi-Wei Lin, Fen Wang, Genping HuangAxially chiral olefins represent an underexplored class of atropoisomers given their conformational flexibility and relatively low configurational stability. Atroposelective access to axially […]Xingwei Li
- Synthesis of γ-Alkylidene Lactones via Molecular Stitching of Carboxylic Acids and Olefins July 3, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03349G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Edis Crnovrsanin, Sourjya Mal, Manuel van GemmerenIn this study, we describe a direct palladium-catalyzed tandem β-C(sp3)–H olefination/lactonization strategy for the one-step synthesis of γ-alkylidene lactones. The reaction is enabled by an N-acyl sulfonamide […]Edis Crnovrsanin
- Correction: Unveiling the switching mechanism of robust tetrazine-based memristive nociceptors via a spectroelectrochemical approach July 3, 2025Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC90148K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.JiYu Zhao, Kun Liu, Wei Zeng, Zhuo Chen, Yifan Zheng, Zherui Zhao, Wen-Min Zhong, Su-Ting Han, Guanglong Ding, Ye Zhou, Xiaojun PengTo cite this article before page numbers are assigned, use the DOI form […]JiYu Zhao
- Selective chemical recycling of polyhydroxybutyrate into high-value hydroxy acid using Taurine organocatalyst July 3, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC02196K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elena Gabirondo, Ainhoa Maiz-Iginitz, Marta Ximenis, Katarzyna Świderek, Daniel Andrés-Sanz, Vicent Moliner, Luis Cabedo, Andrea H. Westlie, Eugene Y.-X. Chen, Daniel Alonso Cerrón-Infantes, Miriam M. Unterlass, Fernando López Gallego, Agustin Etxeberria, Haritz SardonPolyhydroxyalkanoates […]Elena Gabirondo
- Elucidation of the Mechanism of Partial Activation of EPAC1 Allosteric Modulators by Markov StateModelling July 3, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC02112J, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adele Hardie, Frederick G Powell, Silvia Lovera, Stephen Yarwood, Graeme Barker, Julien MichelThe development of selective modulators of exchange protein activated by cAMP (EPAC1/RAPGEF3) would pave the way for novel therapeutic interventions in […]Adele Hardie
- Synthesis and antimicrobial applications of α-peptoid polymers July 3, 2025Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC03968A, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiayang Xie, Weilong Hu, Xi Feng, Zixin Liu, Min Zhou, Runhui LiuThis perspective summarizes recent advances in α-peptoid polymers from synthesis to antimicrobial applications, and discusses current challenges and future directions in the development […]Jiayang Xie
- Synthesis of Benzoquinone Compounds by a Microdroplet-Accelerated Retro-Diels-Alder Reaction July 2, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03761A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nishkant Malkoti, Yifan Meng, Richard N. Zare, Gnanamani ElumalaiThe unique environment of water microdroplets has enabled several novel organic transformations to be reported in recent years. Given the significance of the retro-Diels–Alder (rDA) […]Nishkant Malkoti
- Manganese-Mediated C(sp)–Si Cross-Electrophile Coupling of Alkynyl Halides with Chlorosilanes July 2, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03449C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Quan Lin, Liping Lin, Jingjing Wang, Daohong Yu, Zhengwang Chen, Zhong-Xia WangWe present a manganese-mediated cross-electrophile coupling (XEC) that directly constructs C(sp)–Si bonds between alkynyl halides and chlorosilanes. By leveraging manganese as a […]Quan Lin
- Fine tuning the morphology of peptide-amphiphile nanostructures via co-assembly July 2, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC02935J, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Mercedes Fiora, Huihua Xing, Marilina Cathcarth, Octavio Garate, Santiago Herrera, Agustin S. Picco, Gabriel Ybarra, Martin Conda-Sheridan, Mario TagliazucchiThe self-assembly of peptide amphiphiles (PAs) in aqueous solution yields nanoconstructs displaying a rich […]Maria Mercedes Fiora
- Chemical Diversification of Polyprenyl Quinones for Mechanistic Studies on Menaquinone-Binding Peptide Antibiotics July 2, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03363B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stephen Albert Cochrane, Eilidh Matheson, Roy A M van Beekveld, Markus Weingarth, Paolo Innocenti, Nathaniel I. MartinPolyprenyl quinones, such as ubiquinone and menaquinone, are essential membrane-embedded redox cofactors that are involved in electron […]Stephen Albert Cochrane
- Dimerization of Pillar[5]arene: Length-Adaptive Encapsulation of Long-Chain Guests July 2, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC01403D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shunsuke Ohtani, Keigo Nakagawa, Shigehisa Akine, Kenichi Kato, Tomoki OgoshiEncapsulation of long-chain molecules is challenging because host molecules must capture entire guest structures through interactions at multiple points. Cavitand and capsule molecules bind […]Shunsuke Ohtani
- Electrochemical Ammonia Oxidation with a Homogeneous Molecular Redox Mediator July 1, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC00730E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tarisha Gupta, Sanyam ., Shivani Saraswat, Anirban Mondal, Biswajit MondalAmmonia (NH₃) is a promising carbon-free energy carrier due to its high energy density and hydrogen storage capacity. Its utilization in energy systems relies […]Tarisha Gupta
- Thermal proteome profiling of itaconate interactome in macrophages July 1, 2025Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC02378E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yunzhu Meng, Tiantian Wei, Chenlin Zhang, Anqi Yu, Yuan Liu, Junyu Xiao, Chu WangThermal proteome profiling identified interacting proteins of the immunoregulatory metabolite, itaconate, in macrophages. A novel target, mitochondrial branched-chain-amino-acid aminotransferase (BCAT2), […]Yunzhu Meng
- A perspective of Emerging trends in integrated PFAS detection and remediation technologies with data driven approaches July 1, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC01624J, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Samaneh Yaghoobian, Manuel Alejandro Ramirez Ubillus , Lei Zhai, Jae-Hoon HwangPer- and polyfluoroalkyl substances (PFAS) are highly persistent synthetic chemicals that pose severe environmental and health risks, prompting increasingly stringent regulations. The recent crises […]Samaneh Yaghoobian
- Correction: A planar pentacoordinate oxygen in the experimentally observed [Be5O6]2− dianion July 1, 2025Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC90136G, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rui Sun, Yang Yang, Xin Wu, Hua-Jin Zhai, Caixia Yuan, Yan-Bo WuTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Rui Sun
- Macrocyclization of backbone N-methylated peptides by a prolyl oligopeptidase with a distinctive substrate recognition mechanism July 1, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03723A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Emmanuel Matabaro, Haigang Song, Lukas Sonderegger, Fabio Gherlone, Andrew Giltrap, Samuel Liver, Alvar Gossert, Markus Künzler, James H NaismithMacrocyclization and multiple backbone N-methylations can significantly improve the pharmacological properties of peptides. Since chemical […]Emmanuel Matabaro
- Facile N-C Bond Cleavage and Arene Reduction by a Transient Uranium (II) Complex July 1, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC03694A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.R. A. Keerthi Shivaraam, Leonor Maria, Thayalan Rajeshkumar, Rosario Scopelliti, Ivica Zivkovic, andrzej sienkiewicz, Laurent Maron, Marinella MazzantiComplexes of uranium(II) remain extremely rare and their reactivity is practically unexplored. Here we report that […]R. A. Keerthi Shivaraam
- High throughput screening for the design of protein binding polymers June 30, 2025Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC04391C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Carolin Bapp, Ahmed Z. Mustafa, Cheng Cao, Erica J. Wanless, Martina H. Stenzel, Robert ChapmanHigh throughput polymerisation and screening enables the design of random heteropolymers for protein binding and encapsulation.To cite this article […]Carolin Bapp
- Structural Disorder as a Key to Photoprotection in Eumelanin Multimers June 30, 2025Chem. Sci., 2025, Accepted ManuscriptDOI: 10.1039/D5SC00920K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kavya Vinod, Diana Thomas, Mahesh HariharanEumelanin, a ubiquitous pigment in animals, is known for its ability to protect against UV-induced damage by efficiently dissipating energy as heat. Despite its importance, the mechanisms underlying […]Kavya Vinod
- Ensembles of cationic conjugated polymer and anionic platinum(II) complexes: from FRET properties to application studies in E. coli imaging and singlet oxygen generation June 30, 2025Chem. Sci., 2025, Advance ArticleDOI: 10.1039/D5SC01244A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Angela Lok-Yin So, Jungu Guo, Huanxiang Yuan, Qi Shen, Eric Ka-Ho Wong, Shu Wang, Vivian Wing-Wah YamA series of anionic platinum(II) complexes have been reported to form FRET ensembles with PFP-NMe3+ via electrostatic, […]Angela Lok-Yin So
- Palladium-Catalyzed Redox Diversified Entry to Axially Chiral Styrenes via Asymmetric Olefination with Alkynes July 3, 2025
