RSC – Chem. Sci. latest articles- Design of permeability-optimized target-binding macrocycles via direct preference optimization April 8, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01722C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Heqi Sun, Hong Tan, Yanyi Chu, Jia-Yi Li, Ruixuan Wang, Dongqing WeiMacrocyclic peptides represent a promising therapeutic modality for challenging targets, such as protein–protein interactions. However, their clinical utility is often limited by […]Heqi Sun
- A novel lactam-based AIE building block for high-performance deep-blue electroluminescent materials April 8, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC00940A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Luyao Liu, Jingli Lou, Jiaxing Wan, Yin Li, Hao Xiong, Yu Huang, Dezhi Yang, Han Zhang, Ben Zhong Tang, Zhiming WangA novel building block PADP was efficiently designed and synthesized based on a […]Luyao Liu
- Pyroglutamate pendant block copolymers: evolution of inverse and conventional morphologies from RAFT-mediated PISA April 8, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01206J, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pampa Chowdhury, Kamal Bauri, Priyadarsi DeBy emulating the complex hierarchical assemblies found in bio-derived materials, nanostructural synthetic designs expand material properties and enlarge their capability for versatile applications. Correspondingly, polymerization-induced selfassembly (PISA) emerges […]Pampa Chowdhury
- PANDA: AND Logic-Gated RNA Sensing Enabled by Photo-Activated RCA-Argonaute Cascade April 8, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00827E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xinxin Ke, Heming Fan, Jingwen Qu, Junlan Wang, Yilong Wang, Tengfei Xu, Chuanxia Chen, Chunyi Hu, Tao HuAchieving stable, multiplexed, and affordable nucleic acid detection in a true one-pot format remains a long-standing […]Xinxin Ke
- The Acylative Kinetic Resolution of 1,2-Azaborine Naphthols April 8, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02046A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Martha I Prindl, Aidan P. McKay, David Bradford Cordes, Andrew D. SmithThe enantioselective synthesis of atropisomeric molecules containing stereogenic axes is becoming increasingly important due to their growing incorporation within medicinally relevant compounds. […]Martha I Prindl
- Design Rules for Ternary CO 2 Hydrogenation Catalysts via Literature-Sourced Network Construction and Analysis April 8, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00563B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yoshiki Hasukawa, Fernando Garcia Escober, Shun Nishimura, Keisuke Takahashi, Lauren TakahashiThe development of CO 2 hydrogenation catalysts has largely depended on researchers's trial and error efforts. However, exploring unreported ternary catalysts requires substantial […]Yoshiki Hasukawa
- Ammonia monooxygenase: a work in progress April 7, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01048B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Thomas C. Arndt, Alexander L. Laughlin, Kyle M. LancasterAmmonia monooxygenase (AMO) is a multimeric, multidomain integral membrane protein belonging to the copper membrane monooxygenase (CuMMO) family. This globally proliferated enzyme initiates nitrification in […]Thomas C. Arndt
- High energy density quasi-solid-state lithium batteries using in situ polymerized gel electrolytes April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01543C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zehui Fan, Yingxin Liu, Lanhua Ma, Hang Liu, Qinghao Chen, Yi Wang, Ewa Zygadlo-Monikowska, Yunhua XuCommercial lithium-ion batteries that use liquid electrolytes suffer from limitations in energy density and face significant safety concerns. […]Zehui Fan
- Recent Advances in Site-Specific Modifications of Peptides and Proteins April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09331G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xin-Rong Duan, Meng-Qian Zhang, Geng-Hui Feng, Yan-Mei LiModification at specific sites has long been a central goal in peptide and protein chemistry. Introducing functional groups at specific sites is an ideal state for […]Xin-Rong Duan
- Pd-N-C Shelled Pd Nanoparticle Catalysts for High-Performance Hydrogen Peroxide Electrosynthesis April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09543C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiao Dong, Zi-Xiang Su, Yanyan Jia, Runjia Xing, Sixuan She, Daqin Guan, Sheng Dai, Jinling Wang, Manqing Chai, Zhenshan Hou, Zhiqiang Wang, Hehe Wei, Peijun Hu, Xue-Qing GongMetal-nitrogen-carbon (M-N-C) catalysts have attracted very […]Jiao Dong
- Comment on “Radical-mediated proton transfer enables hydroxyl radical formation in charge-delocalized water” by R. Zhao, Q. Zhang, N. Yang, L. Li, Z. Li and C. Cui, Chem. Sci., 2025, 16, 11954 April 7, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC05396J, Comment Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Willem H. KoppenolCui and coworkers claim that H2O˙+ and HO˙ are formed spontaneously by lowering the pH to below 4. This is thermodynamically most unlikely. Thus, proton transfer does not involve HO˙.To cite this […]Willem H. Koppenol
- Black-Box Data: A new paradigm for biomedicine in the AI era April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01189F, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Luca Naef, Michael BronsteinAs Artificial Intelligence cements its role as a cornerstone of scientific discovery, the field is undergoing a fundamental shift beyond the current transition from "white-box" first-principles models to "black-box" deep...The content […]Luca Naef
- Origins of the Selectivity of Late Transition Metals of Group 9 and Group 10 for Oxidative Addition of C–H vs C–Cl Bonds April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00090H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yehao Qiu, Alistair J Sterling, Kevin K Ikeda, Alexander Zech, Matthias Loipersberger, Diptarka Hait, Martin Head-Gordon, John F HartwigOxidative addition of carbon–hydrogen or carbon–halogen bonds occurs in many reactions catalyzed by late transition-metal […]Yehao Qiu
- ZrO2 induced d-d spatial coordination effects of Ru single-atom catalysts to boost oxygen evolution reaction April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01575A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dan-dan Yu, Bin Liu, Dong-Ming Li, Junkai Yu, Xijie Lan, Shuhong Liu, Zhuxin Li, Pengyun Gao, Yong Zhang, Hong ZhaoProton exchange membrane water electrolysis (PEMWE) is a leading strategy for producing green hydrogen […]Dan-dan Yu
- Electrochemical Functionalization of Pyridines April 7, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00233A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Satabdi Bera, Tushar Singha, Nakul Abhay Bapat, Durga Prasad HariPyridines are important nitrogen-containing heteroaromatics with wide applications in pharmaceuticals, agrochemicals, ligands, and materials science. However, their selective C–H functionalization remains challenging due to […]Satabdi Bera
- Deciphering the Stimuli-Responsive Behavior of TPPE-Incorporated Flexible Metal-Organic Frameworks April 6, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC09651K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.You Fan, Zhikai Zhu, Shuo Zhou, Federico Gorelli, Yuchen Ye, Huixin Hu, Shenghan Zhang, Hongliang Dong, Chang-Zhong Liao, Ziyou Zhang, Zhiqiang ChenAggregation-induced emission luminogens (AIEgens) hold great promise for the design of highly […]You Fan
- Charge-Dependent Modulation of S–H vs O–H Excited-State Intramolecular Proton Transfer April 6, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D5SC10166B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chi-Chi Wu, Hao-Cheng Tsai, Hau-Yu Liu, Ya-Chen Lin, Chih-Hsing Wang, Alexander P. Demchenko, CHAO-TSEN CHEN, Pi-Tai ChouSubstituent effects critically influence electronic coupling and proton-transfer dynamics in excited-state intramolecular proton transfer (ESIPT), yet a […]Chi-Chi Wu
- Selective White Phosphorus Activation and Functionalization with Inorganic Grignard Reagents April 6, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01229A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Franziska Gilch, Jan Brossette, Franz F. Westermair, Wagner Silva, Gábor Balázs, Ruth M. Gschwind, Hendrik Zipse, Robert WolfWe describe the targeted and selective functionalization of white phosphorus (P4) using ‘inorganic Grignard reagents’. Reactions […]Franziska Gilch
- Synthesizability via reward engineering: expanding generative molecular design into synthetic space April 6, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D5SC09263A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dominik Dekleva, Alexey Voronov, Jon Paul Janet, Albin Ekborg, Jure Borišek, Martina H. Rambaher, Hannes H. LoefflerSynthSense couples generative molecular AI with retrosynthetic reward functions to produce novel, drug-like molecules that are not […]Dominik Dekleva
- Stepwise BN bond cleavage by isocyanides: access to the 3-azaborole structural motif April 6, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01836J, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Libo Xiang, Ka Ho Kwan, Yi Jing, Junyi Wang, Alexander Matler, Xuenian Chen, Zhenyang Lin, Qing YeTheBN bond undergoes a [2+1+1] cycloaddition with two equiv of isocyanide, followed by reductive insertion of a […]Libo Xiang
- Design of permeability-optimized target-binding macrocycles via direct preference optimization April 8, 2026
