RSC – Chem. Sci. latest articles- Electrophilic activation of water by a carbene catalyzed by a copper surface June 5, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00488A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yunjun Cao, Joel Mieres-Perez, Julien Frederic Rowen, Elsa Sanchez-Garcia, Wolfram Sander, Karina MorgensternCarbenes are among the most versatile organic intermediates, capable of exhibiting radical, electrophilic, or nucleophilic reactivity. Harnessing this versatility for synthesis […]Yunjun Cao
- Role of the Fe-FeCl₂ Contact Interface in Promoting Redox Reversibility and Electrochemical Kinetics in Fe/FeCl₂-Graphite Molten Salt Battery June 4, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03818B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wenlong Zhang, Xiaohui NingThe Fe/FeCl₂-Graphite battery is an intermediate-temperature molten salt electrochemical system. It employs the solid Fe/Fe2+ redox as the negative electrode reactions and graphite positive electrode based on the intercalation/de-intercalation reaction...The […]Wenlong Zhang
- Modulation strategies for acidic oxygen evolution catalysts June 4, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03328H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Feifei Teng, Zhenlu Wang, Jingqi GuanProton exchange membrane water electrolysis (PEMWE) is a highly efficient, eco-friendly hydrogen generation technology. With advantages such as fast response and superior energy efficiency, it is a crucial […]Feifei Teng
- Organocatalytic Asymmetric Synthesis of Atropisomeric Tetraarylethenes: Design, Properties, and Applications June 4, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03274E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mei An, Chuan-Jun Lu, Fei Xie, Yin-Jian Sun, Zhaofeng Sun, Long-Long Xi, Ren-Rong LiuTetraarylethenes are important π-conjugated molecules with versatile applications in OLEDs, fluorescent probes, and aggregation-induced emission (AIE) luminogens. Access to chiral […]Mei An
- Strategic physicochemical tuning: amphiphilic polymers as molecular regulators of amyloid aggregation and cytotoxicity June 4, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03446B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jimin Kwak, Seongmin Park, Youngjin Kim, Yunha Hwang, Seung Jae Lee, Jeung Gon Kim, Mi Hee LimAmyloidogenesis is a central pathological process in neurodegenerative disorders, yet general chemical principles that enable its predictive […]Jimin Kwak
- Dual Role of a Conjugated Bridge in Intramolecular Singlet Fission: Light-Harvesting Antenna and Energy Funnel June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01678B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jie Kong, Kanad Majumder, Manoj Sharma, Soham Mukherjee, Andrew J Musser, Satish Amrutrao Patil, Woojae KimHerein, an 'antenna-mediated' singlet fission (SF) molecular platform is reported, in which a phenyldiketopyrrolopyrrole (PDPP) chromophore with strong […]Jie Kong
- Pendant Amine-Promoted Complete Eight-Electron Photoreduction of CO2 to Methane by a Molecular Nickel Catalyst June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02569B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liton Seikh, Chandan Das, Abhishek Saini, Gazal Sabharwal, Somnath Guria, Piyali Majumder, Maravanji Shivaramaiah Balakrishna, Goutam Kumar Lahiri, Arnab DuttaSolar-driven CO2 reduction offers a sustainable route to carbon neutrality by converting greenhouse gases […]Liton Seikh
- From Overlooked to Outstanding: A Molecular Silver Complex in Heterogeneous CO₂ Electroreduction June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00957C, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wiebke Wiesner, Kevinjeorjios Pellumbi, Julia Jökel, Ulf-Peter ApfelHeterogenized molecular transition metal complexes, especially silver-based ones, have shown to be highly efficient as catalysts for electrochemical CO2 reduction (eCO2R). Herein we present the application […]Wiebke Wiesner
- PpF: a density functional fine-tuned for noncovalent interactions of protein and peptide residues June 3, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01551D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yini Zhou, Tao Li, Yaqi Li, Jianda Yue, Qifeng Tian, Zhonghua Liu, Donald G. Truhlar, Ying WangThe essence of protein–peptide interactions lies in the noncovalent interactions between amino-acid pairs; accurately calculating interaction energies […]Yini Zhou
- Pulsed electrolysis enables unexpected lactonization of bicyclobutane carboxylic acids June 3, 2026Chem. Sci., 2026, Advance ArticleDOI: 10.1039/D6SC01541G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anton S. Makarov, Liang Yi, Bholanath Maity, Luigi Cavallo, Magnus RuepingPulsed electrolysis drives selective oxidation of BCB-carboxylic acids to 2-oxabicyclo[2.1.1]hexan-3-ones via the formation of a bicyclobutyl radical cation intermediate, as supported by combined […]Anton S. Makarov
- Electronic structure engineering of Zn-based catalysts via anionic regulation for polysulfide adsorption-catalysis in Li-S batteries June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03397K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cheng He, Lingfeng Zhu, Jia Fu, Xiangzeng Meng, Hongfu Liu, Youliang Wang, Zhenfang Zhang, Xiaoning Li, Hui Li, Tianyi Ma, Sheng Liu, Yuhai Dou, Ji Yu, Jianxin Cai, Ze ZhangSluggish sulfur redox kinetics […]Cheng He
- Quantifying the Failure Modes of Current One-step Retrosynthesis Models June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01323F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Suong B. A. Tran, Jihye Roh, Connor W ColeyComputer-aided synthesis planning (CASP) automates retrosynthetic analysis, generally by recursively applying one-step retrosynthesis models within multistep search algorithms to simplify a target molecule into commercially […]Suong B. A. Tran
- Tunable redox hopping charge transport and electrochromism in multivariate MOFs: effects of substitution patterns and number of sulfonic acid groups June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02965E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sumanta Basak, Laura Prince, zhengyu Du, Amanda J. MorrisControlling fundamental electron and ion transport in porous materials is a critical challenge because it dictates the performance, speed, and durability of devices ranging from […]Sumanta Basak
- Formation of the intradimer disulfide bond in human calprotectin maintains metal-withholding function and tunes proteolytic susceptibility June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02543A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aurelio Mollo, Emma Y Cool, Bahar Sakar, Kushol Gupta, Elizabeth NolanHuman calprotectin (CP, S100A8/S100A9 oligomer, MRP8/MRP14 oligomer) is a metal-sequestering protein that contributes to nutritional immunity. Each human CP subunit contains a single […]Aurelio Mollo
- High-Dimensional CRISPR-SERS Interactomics Tracks the Topological Evolution of Plant Viral Pathogenesis and Therapeutic Response June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03368G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.You Dou, Gang Wu, Jun Li, Yuting Wang, Nanke Chen, Tianbing Xu, Xiao-Bo Cai, Tuotuo Zhang, Xinwei Zhang, Xiangyang Li, Junrong Li, Yao SunPrecision agriculture is currently limited by a reliance on viral […]You Dou
- A unified electrocatalytic platform for the chemicals-H2-electricity triad from biomass via interfacial electronic engineering June 3, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03316D, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wei Wang, Xiaoyang He, Shuai Dong, Jianying Wang, Deli Wu, Zuofeng ChenThe selective electrooxidation of biomass-derived 1,3-propanediol (1,3-PDO) to high-value 3-hydroxypropionic acid (3-HP) offers a sustainable route for chemical synthesis but is severely […]Wei Wang
- Chimeric peptide-based radiopharmaceuticals for glioblastoma imaging and therapy by targeting mHsp70 and enhancing BBB penetration June 2, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC00011H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Franziska Schuderer, Ruben Silva, Catarina G. Pinto, Lena Koller, Stefan Stangl, Lurdes Gano, Marco Cavaco, Miguel A. R. B. Castanho, Filipa Mendes, Susanne Kossatz, João D. G. Correia, Angela CasiniGlioblastoma (GBM) is the […]Franziska Schuderer
- Redox-Protonation Landscape of Indenyl-Annulated Perylenes. Chemodivergent Switching of Multistate NIR Chromophores June 1, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC01695B, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Agata Wiencierz-Paś, Liliia Moshniaha, Piotr J. Chmielewski, Tadeusz Lis, Mateusz Waliczek, Ryota Kabe, Marcin StępieńIndene-annulated perylenes merge cyclopentadiene-like benzylic acidity with the multielectron redox chemistry of rylene carbonyl scaffolds, creating discrete redox–protonation (“Pourbaix”) […]Agata Wiencierz-Paś
- Supramolecular Purification of Mono-Adamantane Mixtures via Stabilized Three-Shell Matryoshka Assemblies June 1, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC02321E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Clara Sabrià, Tània Pèlachs, Inhar Imaz, Daniel Maspoch, Ferran Feixas, Xavi RibasThe adamantane (Ad) core is widely used in pharmaceuticals, where it is regarded as a lipophilic “bullet” that enhances the bioactivity of […]Clara Sabrià
- Distinct Adsorption Behavior and Structures of Cell-Penetrating Peptides at a Model Lipid Membrane Interface: A Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy Study June 1, 2026Chem. Sci., 2026, Accepted ManuscriptDOI: 10.1039/D6SC03510H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Subhadip Roy, Mohammed Ahmed, Aniruddha Adhikari, Erika Kinoshita, Satoshi Nihonyanagi, Tahei TaharaArginine-rich cell-penetrating peptides (CPPs) are widely used as molecular delivery vectors, yet the molecular mechanism of their membrane activity and how they […]Subhadip Roy
- Electrophilic activation of water by a carbene catalyzed by a copper surface June 5, 2026
