RSC – Lab Chip latest articles- Selective On-chip DNA Synthesis using Electric Field-assisted PCR April 15, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01200G, PaperDoyeon Lim, Youngjun SongThis study introduces a robust selective on-chip DNA synthesis platform utilizing an electric field-assisted polymerase chain reaction (E-PCR) system based on a microelectrode array. We demonstrate the use of electric...The content of this RSS Feed (c) The Royal Society of ChemistryDoyeon Lim
- Ultra-high throughput droplet microfluidics for cultivation and functional screening of environmental microbial strains and consortia. April 14, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01115A, Tutorial ReviewLuca Potenza, Jozef Krzak, Maciej Stefan Andrzejewski, Adam Pyzik, Tomasz KaminskiScreening of microbial diversity is critical for discovering novel strains with enhanced biocatalytic capabilities. Traditional cultivation techniques often miss rare or slow-growing microorganisms, limiting our understanding of environmental microbiomes and...The content of this RSS Feed (c) The Royal […]Luca Potenza
- Human Hair Regeneration Using Organoids and Hair-on-Chip Technologies April 14, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00095A, PerspectiveImaan A Ahmed, Abbas ShafieeThe hair follicle is a complex, dynamic mini organ that plays various important roles in facilitating the function of human skin. As human hair follicles do not naturally form after...The content of this RSS Feed (c) The Royal Society of ChemistryImaan A Ahmed
- LEGO-Inspired Electrically-Actuated Microfluidics for On-Chip Protein Crystallization and In-Situ X-ray Crystallography April 14, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00021E, PaperSarthak Saha, Logan Chen, Gabrielle R Budziszewski, Sara Koprek, Kaleb Seifert, Aina E. Cohen, Silvia Russi, Sarah EJ Bowman, Sarah L. PerryX-ray crystallography has long been the workhorse technique for enabling the analysis and investigation of 3D protein structures. This understanding is crucial for deciphering protein function, including enzymatic […]Sarthak Saha
- Microfluidic well plates integrated with passive nematode culture chambers for multiplexed chemical toxicity assays in C. elegans April 13, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01165E, PaperBushra Rahman, Purushottam Soni, Atiyya P. Saroyia, William Schenkenfelder, Siva A. VanapalliPNC well plates enable low-intervention, multiplexable C. elegans assays with translational potential for predictive toxicology.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Bushra Rahman
- Region-Specific Proteomic Profiling of Brain Interstitial Fluid via a Micro-invasive Sampling Platform April 12, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00038J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qun Cao, Hannah D Jackson, Aidan J. Duncan, Yufei Cui, Haley O Higginbotham, Stella Lesnik, Yunseo Jo, Jiaquan Yu, Forest White, Michael J CimaInterstitial fluid (ISF) within the brain parenchyma contains secreted factors related […]Qun Cao
- Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery April 12, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01131K, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Doriane Le Manach, Vincent Senez, Matthias NeesCAF-driven matrix remodeling creates quantifiable transport barriers to drug delivery. Tumor-on-chip platforms enable transport phenotyping to decode and target these stromal barriers.To cite this article before page […]Doriane Le Manach
- Microparticle-enabled single cell multiparameter electronic immunophenotyping for selective electroporation April 11, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00180G, PaperMadeline Hoyle, Josiah Rudge, Yuvraj Rallipalli, Aniruddh SarkarDetection of multifrequency impedance signatures of microparticle labeled single cells in a 3D printed microfluidic channel enables real time selective electroporation of cell subpopulations for cell engineering.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Madeline Hoyle
- A rapid in-situ synthesis of bioinspired nanoflowers on a microfluidic dipstick for point-of-care diagnosis of normoglycemic glycosuria † April 9, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00086J, PaperSaminu Abdullahi, Mohamed Ishag Hassan Gama, Mubashir Ali, Zhu Yang , Han Yujia, Jingzhen Li, Yuhang Liu, wang xuzhong, Zedong NieReliable detection of urinary glucose is crucial for the early diagnosis of renal tubular dysfunctions, including normoglycemic glycosuria (NG), a condition characterized by glucose excretion despite normal blood glucose […]Saminu Abdullahi
- A compact low-power valveless piezoelectric micropump with a nested rectification structure April 9, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00060F, PaperJie Shan, Aoyu Ma, Cuixue Ren, Yuren Zhao, Lixia Yang, Jingmin LiThe field of implantable medical devices imposes stringent requirements on piezoelectric micropumps, particularly in terms of low-power operation, miniaturization, and backflow suppression. This study proposes a novel valveless piezoelectric micropump...The content of this RSS Feed (c) The Royal […]Jie Shan
- A Tunable 50 MHz Acoustic Vortex Tweezers for Size-Selective Manipulation and Cell Pre-concentration April 9, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00010J, PaperXiongwei Wei, Xin Wang, Lili Miao, Yi Quan, Chunlong Fei, Yintang YangIn microfluidic bioanalysis, efficient target manipulation, enrichment, and sample pretreatment are key bottlenecks. Although high-frequency ultrasound (>50 MHz) can provide tens of micrometers resolution and enable precise non-contact manipulation, existing...The content of this RSS Feed (c) The Royal […]Xiongwei Wei
- Highly Sensitive Wireless Dual-Spiral Resonant Contact Lens for Continuous Intraocular Pressure Monitoring April 9, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00940E, PaperYing Liu, Zhixian Chen, Xiaoyu Zhao, Lin Xu, Shengli MiContinuous and non-invasive intraocular pressure (IOP) monitoring is crucial for managing glaucoma, a leading cause of irreversible blindness worldwide. However, existing tonometry methods are intermittent and lack the capability to...The content of this RSS Feed (c) The Royal Society of […]Ying Liu
- Facile fabrication of high-density two-dimensional micronozzle arrays using twisted thin-wire molds April 9, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00036C, PaperKoki Takahashi, Kyohei TeraoRotational skewing of thin-wire arrays enables simple fabrication of dense micronozzle arrays with independently connected channels, allowing localized hydrodynamic flow confinement and microscale liquid processing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Koki Takahashi
- A hypoxic microfluidic organoid-on-a-chip system for studying the efficacy of metronidazole-modified nanomaterials against cholangiocarcinoma established within the chip April 9, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01198A, Paperao xie, Zipeng Yao, Qijun Du, Mengjiao Xia, Qinrui Lu, Jiashu Wang, Wenqi Hu, Lin Wu, Chenwei Sun, Youlong Yang, Di Wu, Haijie Hu, Guohua Wu, Shuqi WangCholangiocarcinoma (CCA) is a highly aggressive biliary malignancy characterized by a dismal prognosis. Tumor progression relies heavily on the hypoxic tumor microenvironment […]ao xie
- Topology-Based Coordination Control for Multi-Droplet Tasks in Autonomous Digital Microfluidics April 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00147E, PaperZhen Gu, kunlun guo, Zerui Song, Boyi Feng, Tiaofen Qiu, Jiale Zhou, Bin Shen, Bingyong Yan, Hui-Feng WangDigital microfluidics (DMF) is a versatile technique for parallel and field-programmable control of individual droplets. The challenge of large-scale parallel droplet manipulation in DMF is essentially a cross-scale complex system...The content of […]Zhen Gu
- Bioinspired quality-based sperm sorting in a spiral microfilter-enhanced microfluidic device: enhancing DNA integrity via rheotaxis and boundary dynamics April 8, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00427F, PaperDonya Shahhoseini, Naser NaserifarA bioinspired spiral microfluidic device leverages rheotaxis and boundary dynamics for label-free sperm sorting, reducing DNA fragmentation and enhancing viability, providing a practical solution for challenging semen in assisted reproduction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Donya Shahhoseini
- Sequential Intracellular Delivery of Genetic Coding Molecules Using an Acoustic Electric Microfluidic Platform April 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00941C, PaperMichelle Zhang, Aida Z Taravatfard, Mohammad Aghaamoo, Abraham Phillip LeeIntracellular delivery of genetic coding molecules is a critical step in both fundamental cell biology and the development of cellular and gene therapies. With the emergence of diverse genetic coding...The content of this RSS Feed (c) The Royal Society of […]Michelle Zhang
- Robotic acoustofluidic single-cell picking and placement platform April 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01129A, PaperWanqi Li, Qiu Yin, Jiahui Wu, Chenfan Zhang, Xiaochen Li, Chenyang Zhou, Xianting Ding, Xiang ChenSingle-cell manipulation is essential for investigating cellular heterogeneity and enabling downstream assays, such as single-cell proteomics and drug screening.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Wanqi Li
- Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood April 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00039H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lewis Krzeczkowski, Georgios Nteliopoulos, Simak Ali, Paul Davey, R. Charles Coombes, Ali Salehi-ReyhaniA microfluidic band-stop filter selectively enriches viable CTC-sized cells from undiluted whole blood while excluding smaller and larger blood cells. Captured cells […]Lewis Krzeczkowski
- High-Throughput Microfluidic Platform for Modelling Inflammatory Responses of Human Articular Chondrocytes under Variable Fluid Shear Stress April 7, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01167A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aldeliane Maria da Silva, Priscila C Rodrigues, Meriem Lamghari, Hoang-Tuan Nguyen, Jere Kettunen, Sebastien Mosser, Prateek Singh, Ali Mobasheri, Gabriela LoriteInflammation plays a critical role in osteoarthritis (OA), a debilitating joint disease characterized by […]Aldeliane Maria da Silva
- Selective On-chip DNA Synthesis using Electric Field-assisted PCR April 15, 2026
