RSC – Lab Chip latest articles- Gravity-induced tunable asymmetric droplet splitting for flexible and precise reagent formulation on vertical digital microfluidics. December 29, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00868A, PaperJuyue Dong, Zerui Song, kunlun guo, Hang Xu, Zhibei Qu, Zhen Gu, Hui-Feng WangDigital microfluidic enables parallel, quantitative and flexible handling of discrete droplets via electrowetting on dielectric (EWOD) force. However, droplet splitting behavior in conventional digital microfluidics is limited by the geometry...The content of this RSS Feed (c) […]Juyue Dong
- A mechanomimetic model of skin fibrosis December 29, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00560D, PaperAlberto Pappalardo, Deniz Ornek, Laura Garriga Cerda, Charlotte Y. Lee, Kristin Myers, Jeffrey W Kysar, Hasan Erbil AbaciSkin fibrosis results from excessive extracellular matrix (ECM) deposition and tissue remodeling due to persistent inflammation and mechanotransduction dysregulation. Current in vivo animal models lack human relevance, while conventional 2D...The content of […]Alberto Pappalardo
- A comprehensive toolkit for manipulation and analysis of sprouting capillary networks based on magnetic ordering of multiple EC-coated microcarriers and their use in tissue modelling and drug testing. December 24, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00664C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Katarzyna Olga Rojek, Antoni Wrzos, Fabio Maiullari, Konrad Gizynski, Maria Grazia Ceraolo, Claudia Bearzi, Roberto Rizzi , Piotr Szymczak, Jan GuzowskiDespite significant developments in endothelial-cell (EC) manipulation techniques, an in vitro model of a […]Katarzyna Olga Rojek
- Magnetophoretic long jump of magnetic microparticles in an engineered magnetic stray field landscape for highly localized and large throughput on-chip fractionation December 23, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01000D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rico Huhnstock, Lukas Paetzold, Piotr Kuświk, Arno EhresmannOn-chip spatial separation of superparamagnetic microparticles was achieved using an engineered magnetic stray field landscape created by an artificial magnetic domain pattern. It potentially enables pre-sorting of […]Rico Huhnstock
- A Tumor Spheroid Array Chip for High-Fidelity Evaluation of Liposomal Drug Delivery Through the EPR Effect December 23, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00893J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yedam Lee, Sujin Kim, Hyeyeon Koh, Jung Yeon Han, Jihoon Ko, Yeonwoo ParkConventional two-dimensional (2D) culture systems fail to recapitulate the structural and functional complexity of the tumor microenvironment (TME), limiting their translational relevance […]Yedam Lee
- A novel microfluidic multichannel electrochemical cell for multiplexed monitoring of water pollutants December 22, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00825E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tong Liu, Ivo Tichý, Jiří Homola, Amir M. AshrafiA microfluidic multichannel (4×) electrochemical cell (MMEC) was developed. Multiplexed determination of selected water pollutants Hg2+ and Pb2+ ions, catechol, and H2O2 was carried out with […]Tong Liu
- Direct access and recovery feature of solid precipitates embedded in microfluidic device December 19, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00816F, PaperMasashi Kobayashi, Risa Fujita, Faisal bin Nasser SARBALAND, Masahiro Furuya, Daiki TanakaDroplet microfluidics, which generates and manipulates water-in-oil microdroplets within continuous phases, has emerged as a compelling platform in modern science. The core advantage of this technology lies in the fact...The content of this RSS Feed (c) The Royal […]Masashi Kobayashi
- Gut Health Monitoring via Intestinal Barrier Function Screening by Transepidermal Microneedle-based Sensor December 19, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01004G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nicolas Grégoire Maïno, Sihui Xu, Petter Brodin, Onur ParlakThe growing prevalence of chronic digestive disorders, such as inflammatory bowel disease, underscores the urgent need for innovative solutions that enable longitudinal monitoring of disease progression […]Nicolas Grégoire Maïno
- Magnetic smartphone microflow cytometry enables rapid CD4/CD8 T cell quantification December 19, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00801H, PaperHee Sik Shin, Sung Joo Lee, Jae In Kim, Jung Ho Kim, Jun Yong Choi, Su Jin Jeong, Sungyoung ChoiWe present MACC, a smartphone-based microflow cytometry platform for rapid, fully quantitative CD4+/CD8+ T-cell counting without fluorescent labels.To cite this article before page numbers are assigned, use the DOI form […]Hee Sik Shin
- Directed dielectrophoretic assembly and separation on microelectrodes patterned via stereolithography 3D-printed shadow masks December 18, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00829H, PaperEunhwa Jo, Chanwook Cha, Yeongjun Kim, Jeongjae Seo, Eun Jung Lee, Koohee HanBy employing an SLA-fabricated shadow mask for precise electrode patterning, this work demonstrates that dielectrophoretic separation and assembly can be robustly and reliably controlled.To cite this article before page numbers are assigned, use the DOI form of […]Eunhwa Jo
- Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow December 17, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00742A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aaron D. Morgan, Robert Dzhanaev, Andrea Gorgels, Jan Ritter, Johanna C. Clauser, Felix Stockmeier, Lucas Stüwe, Christian Böhm, Stefan Jockenhoevel, Ulrich Steinseifer, Willi Jahnen-DechentA miniaturized biohybrid material testing system, compatible with live cells, that […]Aaron D. Morgan
- An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection December 17, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01096A, PaperZihan Wang, Fuwan Yang, Shuai Zeng, Rui Sun, Qifei Hu, Yichen DuAn integrated valved microfluidic device was developed combining RPA, CRISPR, and lateral flow for nucleic acid detection. With pre-lyophilized reagents and simple valve operation, it achieves 20-copy sensitivity for HPV16/18 detection.To cite this article before page numbers are […]Zihan Wang
- Detecting HIV in Whole Blood using an Integrated Paper-based Consumable that Enables Direct Amplification of Purified RNA from Paper December 17, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00897B, PaperAlexander Evans, Alexandra Sogn, Andrea C Mora, Moses Arthur, Justin Leach, Sebastian Bosch, Shruthika Araselvan, Jeffrey Beard, Stephen Dewhurst, Charles R. Mace, Benjamin Locke MillerA definitive diagnosis of HIV typically requires a positive nucleic acid test. Limited access to these tests means that initiation of anti-HIV therapy is delayed […]Alexander Evans
- Sacrificial Oil Shell Method for the Generation of Alginate Microbeads Adapted to Multicellular Spheroid Culture December 17, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00913H, PaperLeon Rembotte, Jean Cappello, Adrien Dewandre, Marie Mettler, Jean Marcel Constantin Septavaux, Pierre Nassoy, Benoit ScheidThree-dimensional cell culture provides a powerful framework for studying the growth of tissue in vitro. To account for biological variability, it is important to generate a large number of model...The content of this RSS […]Leon Rembotte
- Sheathless prefocusing in SU-8/PDMS hybrid microchannels via sidewall-assisted bimodal acoustic field cascading December 16, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00887E, PaperHaixiang Zheng, Yang Zhao, Yuanpeng Ma, Suyu Ding, Dachuan Sang, Zeyi Wang, Dong Zhang, Xiasheng GuoAn SU-8/PDMS hybrid microchannel utilizes sidewall-assisted bimodal acoustic field cascading to perform high-ratio sheathless prefocusing of cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Haixiang Zheng
- Tunable Single-Column Deterministic Lateral Displacement Device by Adjustable Crossflow December 16, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00786K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Miftahul Jannat Rasna, James C SturmConventional deterministic lateral displacement (DLD) devices are popular for continuous size-based separation of micro-particles at a high resolution through a tilted array of periodically placed micro-posts. However, the conventional […]Miftahul Jannat Rasna
- LFC-plus: simultaneous multicolour volume cytometry for high-throughput single-cell analysis December 16, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00962F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhi Ling, Wenhao Liu, Kyungduck Yoon, Zijun Gao, Keyi Han, Mithila Sawant, Aparna Kesarwala, Shu JiaWe report LFC-plus, a simultaneous multicolor volumetric cytometry platform for high-throughput single-cell analysis.To cite this article before page numbers […]Zhi Ling
- Surface acoustic wave-assisted swing-angle spray: from mechanism investigation to deposition characteristics and in vivo wound healing December 16, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00964B, PaperChenhui Gai, Yu Gu, Qutong Yang, Suxiao Zhao, Yizhan Ding, Yulin Lei, Junlong Han, Hong Hu, Chen FuSAW-assisted swing-angle spray (SAW-SAS) uses frequency modulation to steer an aerosol jet (5–45°). This breaks the conventional 22° Rayleigh angle constraint, enabling precise drug delivery for accelerated in vivo wound healing.To cite […]Chenhui Gai
- An integrated microfluidic system for automated extraction of in vitro transcribed mRNAs via probe-coated magnetic beads December 15, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00938C, PaperSwati T. Gurme, Yu-Ting Su, Bhushan Koparde, Lily Hui-Ching Wang, Gwo-Bin LeeA fully integrated microfluidic device enabling in vitro transcription (IVT), DNase treatment, and mRNA extraction using probe-coated magnetic beads was developed. The system achieved 93.35 ± 2.34% capture and 47.86 ± 10.14% release efficiency.To cite this article before […]Swati T. Gurme
- Acoustic probing of new biomarkers for rapid sickle cell disease screening December 12, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D4LC00847B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nakul Sridhar, Meiou Song, Michael H. B. Stowell, Kathryn L. Hassell, Xiaoyun DingA SAW-integrated microfluidic device enables sickle cell disease screening by acoustic probing of two new biomarkers—RBC lysis temperature and plasma protein precipitation—offering […]Nakul Sridhar
- Gravity-induced tunable asymmetric droplet splitting for flexible and precise reagent formulation on vertical digital microfluidics. December 29, 2025
