RSC – Lab Chip latest articles- Label-free monitoring of therapy response in 3D spheroids using lab-on-a-chip impedance spectroscopy January 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00815H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gregory Macke, Maulee Sheth, Manju Sharma, Supasek Kongsomros, Maria Lehn, Trisha M Wise-Draper, Vinita Takiar, Leyla EsfandiariThe high incidence and mortality of cancer continue to drive research and development of effective therapies. Lab-on-a-Chip (LOC) […]Gregory Macke
- Lateral flow biosensors for low abundance detection of brain natriuretic peptide with enzyme-free amplification January 8, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00793C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Menghan Zhang, Tao Xu, Pawel Jajesniak, Giulia Core, Zhuoer Zeng, Maha Mansour Mohamed Shalaby, Julien Reboud, Jonathan M. CooperA lateral flow-enabled, dual-aptamer, enzyme-free amplification circuit for biosensing of heart failure in minutes at room […]Menghan Zhang
- A deep dive into hydrodynamic dispersion in microfluidic systems January 8, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00869G, Critical ReviewSeyed Nezameddin Ashrafizadeh, Mahdi Khatibi, Iman AslaniA unified framework integrating hydrodynamic, electrokinetic, and surface-controlled dispersion mechanisms reveals how microchannel geometry and interfacial design govern solute band evolution in lab-on-a-chip systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Seyed Nezameddin Ashrafizadeh
- In situ imaging of fluid dynamics and nanocarrier nucleation inside microfluidic mixing devices January 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00947B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christopher Hauss, Alexander Erb, Johannes Most, Johanna Steinmann, Robert Stark, Stefanie Gier, Maike WindbergsAlthough microfluidic-based nanoprecipitation represents a powerful approach for the reproducible fabrication of various nanosized drug carrier systems, industrial translation remains limited. […]Christopher Hauss
- Flow by design: a guided review of microfluidics for wearable biosensors January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00628G, Tutorial Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Julieta Nava-Granados, Katherine Vasquez, Bryan U. Medina, Catherine Wang, Jose R. Moreto, Juliane SempionattoThis review offers a practical guide to designing microfluidic systems for wearable biosensors, covering materials, fabrication, and fluid handling, with […]Julieta Nava-Granados
- Affordable, cleanroom-free millifluidic production of targeted lipid nanocarriers via additive manufacturing January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D3LC00995E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Callum D. Hay, Suchaya M. Mahutanattan, Colin P. Pilkington, Miguel Paez-Perez, Kimberly A. Kelly, Yuval Elani, Marina K. Kuimova, Nicholas J. Brooks, Michela Noseda, James W. Hindley, Oscar CesAffordable, clean room-free PMMA vertical flow-focusing […]Callum D. Hay
- Lab-on-a-chip insights: advancing subsurface flow applications in carbon management and hydrogen storage January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00428D, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Junyi Yang, Nikoo Moradpour, Lap Au-Yeung, Peichun Amy TsaiLab-on-a-chip platforms offer a powerful and versatile approach for visualizing and quantifying subsurface flow phenomena relevant to carbon capture and utilization (CCUS), enhanced oil recovery […]Junyi Yang
- Microfluidic shape-based separation for cells and particles: recent progress and future perspective January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00826C, Tutorial ReviewMuhammad Soban Khan, Raihan Hadi Julio, Mushtaq Ali, Sebastian Sachs, Christian Cierpka, Jörg König, Jinsoo ParkThis review comprehensively summarizes working mechanisms of various microfluidic shape-based separation for cells and particles and provides future perspectives based on current challenges for biomedical and clinical applications.To cite this article before page […]Muhammad Soban Khan
- Paper-based microfluidics for wearable soft bioelectronics January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00754B, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Feng Zhang, Ganggang Zhao, Qunle Ouyang, Sicheng Chen, Zheng YanWe provide a comprehensive review of state-of-the-art paper-based microfluidic devices for wearable soft bioelectronics, emphasizing innovative materials and device designs that enable on-skin biofluid […]Feng Zhang
- AI-enabled wearable microfluidics for next-generation infection monitoring and therapeutics January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00733J, Critical ReviewYan Zhou, Xiaoyu Zhu, Kai Qu, Feng XuAI-driven wearable microfluidic systems integrating mechanomedicine principles offer transformative potential for infection diagnosis and therapeutic control. They can shift infectious disease management toward prevention and personalized care.To cite this article before page numbers are assigned, use the DOI form of citation […]Yan Zhou
- Modeling amyotrophic lateral sclerosis (ALS) in vitro: from mechanistic studies to translatable drug discovery January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00577A, Tutorial ReviewKathryn G. Maskell, Anthony L. Cook, Anna E. King, Tracey C. Dickson, Catherine A. BlizzardALS causes degeneration of the corticomotor system. Developing effective in vitro models of this complex disease requires careful selection of cell sources and thoughtful model design to achieve reliable experimental outcomes. Created with BioRender.To […]Kathryn G. Maskell
- Microfluidic tools for electrochemical energy storage and conversion: advances, applications, and research opportunities January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00445D, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Caio Vinicios Juvencio da Silva, Erik KjeangWe highlight key developments and research applications of microfluidic cells in electrochemical energy storage and conversion systems, focusing on their role as analytical tools and research platforms […]Caio Vinicios Juvencio da Silva
- Microfluidics for cell therapy and manufacturing in oncology and regenerative medicine January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00492F, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Josie L. Duncan, Julio P. Arroyo, Rafael V. DavalosA review of the unique advantages of microfluidic-based approaches in cell-therapy and manufacturing for cancer treatment and regenerative medicine.To cite this article before page numbers […]Josie L. Duncan
- Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00875A, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yansong Peng, Esak LeeThe lymphatic system—integral to fluid balance, immune surveillance, and lipid absorption—is frequently overlooked despite its vital roles.To cite this article before page numbers are assigned, use the DOI form of […]Yansong Peng
- A review of microfluidic technologies for thermal management in flexible electronics January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00906E, Critical ReviewMingzi Liu, Jiahao Sun, Zuowei Sun, Yawen Xiao, Yi Chen, Jiyu Li, Xinge YuThis review explores microfluidic thermal management mechanisms, materials, and designs. It highlights applications in device-level cooling, personal thermoregulation, and human–machine interfaces, while outlining challenges and future prospects.To cite this article before page numbers are assigned, […]Mingzi Liu
- Light driven polymer thin films as flying robotic chips in the sky January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00900F, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jianfeng Yang, Hao ZengWe review interdisciplinary efforts to create miniature aerial systems with mid-air controllability and robotic capabilities using responsive thin-film materials.To cite this article before page numbers are assigned, use the DOI […]Jianfeng Yang
- Blood microfluidics: progress and challenges January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00059A, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sana Sheybanikashani, Jian Zhou, Ian PapautskyRecent advances in blood microfluidics have enabled rapid, precise, and cost-effective processing of whole blood. This review examines emerging microfluidic platforms categorized by sample type, including lysed blood, […]Sana Sheybanikashani
- Microcavity-assisted microfluidic physical sensors: materials, structures, and multifunctional applications January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00822K, Critical ReviewXinyi Qu, Jianfeng Ma, Degong Zeng, Jinan Luo, Jingzhi Wu, Chuting Liu, Zhikang Deng, Lvjie Chen, Rongkuan Han, Yancong Qiao, Jianhua ZhouThis review discusses recent progress in materials, fabrication methods, and sensing mechanisms for microcavity-assisted microfluidic physical sensors, and discusses future directions toward broader adoption and scalable deployment.To […]Xinyi Qu
- Integrated DEP presorting and wireless electrode array for high-throughput selective single-cell isolation January 7, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00945F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Thilini N. Rathnaweera, Dhatchayani Rajkumar, Robbyn Kimberly AnandRare cell heterogeneity significantly impacts diagnosis, prognosis, therapeutic options and responses, particularly in diverse diseases like cancer. While single-cell analysis is the most effective route, isolating cells […]Thilini N. Rathnaweera
- Structure-enabled liquid manipulation: bioinspired control across all dimensions January 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00828J, Critical ReviewSiqi Sun, Liqiu Wang, Yiyuan ZhangThis review details how bioinspired, structure-based strategies enable precise liquid control across 1D, 2D, and 3D spaces for targeted delivery, complex transport, and programmable interfaces.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Siqi Sun
- Label-free monitoring of therapy response in 3D spheroids using lab-on-a-chip impedance spectroscopy January 8, 2026
