RSC – Lab Chip latest articles- Oxygen-free discontinuous dewetting in a degassed mold for anisotropic colloidal hydrogel microparticle synthesis November 14, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00928F, PaperJiwoo Kim, Jun Hee Choi, Jeongmin Kim, Jihyun Kim, Yoon Ho Roh, Ki Wan BongAnisotropic colloidal hydrogel microparticles offer unique advantages owing to their shape-dependent interactions, and enhanced diffusion and reaction kinetics, which is favorable in solution-based processes. However, their fabrication remains difficult, mainly...The content of this RSS Feed […]Jiwoo Kim
- Realization of Rapid Diabetic Retinopathy Screening with Lipocalin 1 in Tear Using Enhanced Immunofluorescence Photonic Crystal Microchip November 14, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00919G, PaperKullaphat Nitayachat, Dhrubajyoti Das, Pei-Yi Chen, Sheng-Min Hsu, Jhih-Cheng Wang, Han-Sheng ChuangDiabetic retinopathy (DR) is a major cause of preventable blindness, but current diagnostic tools rely on expensive imaging devices, specialized expertise, and, in some cases, invasive procedures, limiting accessibility in...The content of this RSS Feed (c) The Royal […]Kullaphat Nitayachat
- Sol-gel coating-derived liquid marbles as highly efficient micro-photobioreactors for cyanobacterial cultivation November 13, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00759C, PaperMei Duan, wenjun Tian, Xianglong Pang, rongtao Li, junjie Wang, xinxin Cui, Lingao Yang, Xiaoguang LiMonolayer nanoparticle-covered liquid marbles (mNPc LMs), fabricated using a sol-gel SiO2 coating as the particle source, were developed as micro-photobioreactors (PBRs) for high-efficiency cyanobacterial cultivation at the laboratory scale. Compared...The content of this RSS […]Mei Duan
- Use of poly(glycerol sebacate) as an alternative to poly(dimethylsiloxane) as a platform for making micro-fluidic channels November 13, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00851D, PaperYasmeena Ashraf, Animangsu GhatakPoly(dimethylsiloxane) (PDMS) has been used extensively for making microfluidic devices because of several favorable features: optical transparency, bio-compatiblity, easy moldability and its inertness towards most materials. However, PDMS is non-biodegradable...The content of this RSS Feed (c) The Royal Society of ChemistryYasmeena Ashraf
- Cement-on-a-chip: a microreactor for operando studies of the carbonation curing of cementitious materials November 13, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00638D, PaperValentin Hérault, Eddy Foy, Émeline Charon, Gaëtan Touzé, Celine Cau-Dit-Coumes, Stéphane Poyet, Corinne Chevallard, Mark A. LevensteinOwing to the high carbon emissions associated with the production of Portland cement clinker and its use in concrete, the construction industry is interested in the development of more sustainable...The content of this […]Valentin Hérault
- High frequency acoustofluidic based controllable drug delivery system November 12, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00771B, PaperRui You, Shuting Pan, Yuan Ning, Hongxiang Zhang, Tiechuan Li, Bo Long, Dapeng Ye, Xuexin DuanControllable drug delivery systems play an important role in personalized and precision medicine, particularly for long-term therapies. However, current release profiles, such as pulse, first-order, and zero-order releases, frequently fall...The content of this RSS […]Rui You
- An integrated microfluidic system with shear force control for automatically modified mRNA display technique for screening high-specificity peptide probes November 12, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00914F, PaperHao-Yen Wang, Shih-Yu Shen, Lily Hui-Ching Wang, Gwo-Bin LeeWe developed a low-cost, integrated microfluidic system (IMS) featuring micropumps, microvalves, micromixers, and thermoelectric modules that, for the first time, fully automated the modified-mRNA display technique for the screening of...The content of this RSS Feed (c) The Royal Society of ChemistryHao-Yen Wang
- Dual-channel six-step linear concentration gradient microfluidic chip for orthogonal combination drug screening in head and neck tumor cells November 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00572H, PaperJingru Liao, Zhimi Zhang, Guiquan Zhu, Dan Liu, Zhihao Tu, Wangang Zhu, Tao Dong, Ling Li, Zhuqing WangA dual-channel microfluidic chip generates stable six-step drug gradients for head and neck tumor organoids, enabling rapid, low-cost, and precise combination drug screening with results matching conventional assays.To cite this article before […]Jingru Liao
- A microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions November 12, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00937E, PaperWenxin Wang, Jingwei Cui, Yufei Guo, Xuesong Kang, Hong Liu, Zikai HaoThe blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity.We developed a physiologically relevant human neurovascular unit microfluidic...The content of this RSS Feed (c) The Royal […]Wenxin Wang
- Microfluidic Analysis of Salt-Stress-Mediated Antibiotic Tolerance in Mycobacterium smegmatis November 11, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00713E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Akanksha Agrawal, Dhananjay Udaya Kumar, Raju Mukherjee, Dileep MampallilUnderstanding how bacteria respond to complex environmental stresses is essential for addressing antibiotic resistance. In the natural environment, bacteria can experience salt stress, for instance, due […]Akanksha Agrawal
- Engineering Osteoclast Resorption Units via Sacrificial Microgels in a Bone-on-Chip Platform November 11, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00682A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francisco Conceição, Nuno Araújo-Gomes, Johanna F. A. Husch, Malin Becker, Jeroen J. J. P. van den Beucken, Jeroen Leijten, Liliana Moreira TeixeiraBone remodeling is a tightly regulated process essential for skeletal health, occurring within […]Francisco Conceição
- Reversible and reusable compartmentalized thermoplastic chip for coculture of dorsal root ganglion neurons November 11, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00666J, PaperSolène Moreau, Raul Flores-Berdines, Tatiana El Jalkh, Anne Simon, Guillaume Taret, Anna Fomina, Céline Dargenet-Becker, André Estevez-Torres, Sophie Bernard, Hugo SalmonCompartmentalized microfluidic chips play an important role in understanding the cellular mechanisms involved in neurodegenerative disorders. Dorsal root ganglia are a well-established model for modelling the peripheral nervous system […]Solène Moreau
- Advancing Liquid Biopsy: Whispering Gallery Mode Laser Detection of HER2 on Extracellular Vesicles November 10, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00269A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sentayehu Fetene Wondimu, Richa Khanduri, John Atanga, Marc Hippler, Andreas Hofmann, Christoph Hussal, Daria Kohler, Sarah Kraemer, Uwe Bog, Tobias Wienhold, Meike Koenig, Sebastian Köber, Timo Mappes, Heinz Kalt, Jörg Lahann, Wolfgang Freude, Johnathan […]Sentayehu Fetene Wondimu
- Multiscale microfluidic platform with vacuum-driven chambers for automated high-volume ssDNA generation November 6, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00785B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anni Hu, Yang Bu, Yuze Liu, Yung Ching Lee, Sheng Ni, Levent YobasMultiscale integration of vacuum-driven chambers into microfluidics offers a scalable and automated platform for preparative applications requiring high-volume throughput. This is demonstrated […]Anni Hu
- Surface Acoustic Wave Hemolysis Assay for Evaluating Stored Red Blood Cells November 6, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00652J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Meiou Song, Colin C Anderson, Nakul Sridhar, Julie Reisz, Leyla Akh, Yu Gao, Angelo D'Alessandro, Xiaoyun DingBlood transfusion remains a cornerstone of modern medicine, saving countless lives daily. Yet the quality of transfused blood […]Meiou Song
- Immune cell infiltration of patient derived glioblastoma cell spheroids in acoustic levitation in bulk acoustic wave devices November 5, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00249D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xavier Mousset, Shuake Kuermanbayi, Chloé Dupuis, Nathan Jeger-Madiot, Virgile Delaunay, Ahmed Ibdaih, Elias A. El-Habr, Hervé Chneiweiss, Marie-Pierre Junier, Jean-Luc Aider, Jean-Michel PeyrinAn acousto-fluidic bioreactor allowing the culture of patient-derived gliobastoma tumoroids in acoustic […]Xavier Mousset
- Development of an Acute Inhalation Toxicity Testing Method Based on a Lung-on-a-Chip November 4, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00693G, PaperGa-Eun Kim, Yubin Han, In Jae Bang, Jung Eun Lim, Ha Ryong KimTo date, no in vitro test methods for acute inhalation toxicity have been adopted under the OECD Test Guidelines. One major challenge is the difficulty in mimicking the complex physiological...The content of this RSS Feed (c) The […]Ga-Eun Kim
- An ischemic stroke-on-a-chip model integrated with machine learning for screening of drug candidates November 3, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00517E, PaperJiayue Liu, Peng Wang, Peihan Lian, Jianhua QinA human iPSC-derived blood–brain barrier chip mimicking ischemic stroke pathology enables multi-omics profiling and AI-based drug screening for barrier protection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Jiayue Liu
- Smarter cell sorting: droplet microfluidics meets pick-and-place sorting November 3, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00550G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Olivia Gerhard, Steffen Schneider, Michaela Dehne, Janina Bahnemann, Klaus Palme, Ralf Welsch, Oleksandr Dovzhenko, Qiuju Yu, Michael Köhler, Jialan Cao, Alexander GroßA microfluidic transfer tool (MTT) was designed to pick objects and store them […]Olivia Gerhard
- Real-rock microfluidic platform for quantifying chemical dissolution and mechanical erosion in a multiphase environment November 3, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00773A, PaperChen-Xing Zhou, Ran Hu, Hang Deng, Bowen Ling, Zhibing Yang, Yi-Feng ChenA real-rock microfluidic platform integrating fluorescence microscopy, micro-PIV, and ion chromatography quantifies pore-scale dissolution and mechanical erosion in multiphase flow, revealing a CO2-bubble-controlled regime shift with increasing Pe.To cite this article before page numbers are assigned, use the […]Chen-Xing Zhou
- Oxygen-free discontinuous dewetting in a degassed mold for anisotropic colloidal hydrogel microparticle synthesis November 14, 2025
