RSC – Lab Chip latest articles- DCMiC: a double-cylinder micro-chamber platform for high-throughput drug screening and modeling of microenvironmental resistance in Ewing sarcoma Tháng 12 9, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00856E, PaperJaehun Lee, Muyi Ye, Mikayla Ybarra, Joy Fei, Yuan Gao, Chao MaWe developed a simple yet novel double-cylinder micro-chamber (DCMiC) platform for high-throughput drug screening and modeling of microenvironmental resistance in Ewing sarcoma.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Jaehun Lee
- Correction: Sequential trench well based microfluidic platform to isolate bacteria from whole blood with large volume processing Tháng 12 9, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC90128F, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cheonggyu Lee, Gi Yoon Lee, Hyelyn Joo, Hamin Kim, Junwon Kang, Tae Hyun Kim, Jonghyun Ha, Sunghoon Kwon, Jungil ChoiTo cite this article before page numbers are assigned, use the DOI form of citation […]Cheonggyu Lee
- Online Affinity Micro Free-Flow Electrophoresis for the Continuous Monitoring of Insulin via a Competitive Immunoassay Tháng 12 8, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00745C, PaperGretchen S. Burke, Seokwon Jo, Emilyn U. Alejandro, Michael T BowserAn online, micro free-flow electrophoresis (µFFE) assay was developed for the real-time measurement of insulin in a continuous, competitive immunoassay. Fluorescently labeled insulin and anti-insulin monoclonal antibody were mixed with...The content of this RSS Feed (c) The Royal Society […]Gretchen S. Burke
- Attoliter-level droplets ordered array based on acoustic nanoscissors Tháng 12 4, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00807G, CommunicationWei Wei, Zhaoxun Wang, Yiming Liu, Xinyuan He, Bingnan Wang, Yaping Wang, Menglun Zhang, Xuexin DuanIn the field of nano-fluidics, the generation and manipulation of minuscule droplets with volumes ranging from attoliters (aL) to femtoliters (fL) represents a crucial frontier. Such ultrasmall droplets exhibit immense...The content of this RSS […]Wei Wei
- Rapid Scaffold-Free Cell Sheet Formation and Their Patterning as Building Blocks of Complex 3D Tissue Constructs Tháng 12 3, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00678C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maedeh Khodamoradi, Seyedaydin Jalali, Yufei Chen, Maria Hutter, Faraz Chogan, Alisa Douglas, Graham Rix, Bhavishya Challagundla, Margarita Elloso, Marc Jeschke, Ponnambalam Ravi SelvaganapathyThree-dimensional (3D) cell cultures offer superior potential in replicating native tissue microenvironments […]Maedeh Khodamoradi
- An In Vitro Organ-on-Chip Model for Studying Neuron-Keratinocyte Interactions In Sensory Response Through Electrophysiology Tháng 12 3, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00867K, CommunicationThomas Bessy, Anthony Martinez, Camille Baquerre, Corinne Grégoire, Aurélie Batut, Aurore Berthelin, Louise Dubuisson, Séverine Teluob, Audrey Azéma, Laurène Roussel Berlier, Damien Lelièvre, alexandre guichardThis study introduces a human-relevant in vitro model using iPSC-derived sensory neurons and keratinocytes in MEA-integrated microfluidic chips. Neurons expressed nociceptor markers, showed TRPV activity, […]Thomas Bessy
- Therapeutic Extracellular Vesicle Preparation via Sequential Electrophoretic Enrichment and Counterflow Microdialysis Tháng 12 2, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00870K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sima Mehraji, Nicholas H Pirolli, Raith Nowak, Steven M Jay, Don L DeVoeA microfluidic platform designed to enhance the development of extracellular vesicle (EV)-based therapeutics is presented. The two-chip system combines rapid electrokinetic concentration […]Sima Mehraji
- Boronate-mediated covalent and oriented immobilization of antibodies on the PDMS surface toward improved capture of circulating tumor cells Tháng 12 2, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00862J, PaperKe-Hong Lyu, Jin-Wei Chen, Dun-Yuan Jin, Yu-Ju Huang, Hsiung-Lin Tu, Avijit K. Adak, Chun-Cheng LinOriented boronate-mediated covalent immobilization of native antibodies on PDMS microchannels enhances antigen recognition and circulating tumor cell capture.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Ke-Hong Lyu
- Microfluidic flow-based spatial control of dual-species bacterial adhesion for population-dependent biofilm formation Tháng 12 2, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00752F, PaperSeung Hui An, Heon-Ho Jeong, Jaesung Kim, Chang-Soo Lee, Heon-Ho JeongIn nature, bacteria usually exist as multispecies communities embedded in biofilms, a survival strategy that provides numerous ecological advantages. Biofilm formation is often affected by the physicochemical properties of surfaces,...The content of this RSS Feed (c) The Royal Society […]Seung Hui An
- Modeling the effects of radiation on neurogenesis using an in vitro neurogenic niche approach Tháng mười một 27, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00498E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Laura Nicoleti Zamproni, Julia Rogal, Polyxeni Nikolakopoulou, Klas Blomgren, Marimélia Aparecida Porcionatto, Anna HerlandA microfluidic neurogenic niche model enables investigation of radiation-induced inflammatory effects on neural stem and progenitor cells, providing insights into mechanisms […]Laura Nicoleti Zamproni
- Navigation and selection of spermatozoa in a radial flow microfluidic device Tháng mười một 27, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00778J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ali Karimi, Xieergai Jiang, Alireza AbbaspourradThe rheotactic behavior of spermatozoa in an outward radial flow was studied using a combination of theoretical and experimental approaches. Simulations suggested that at moderate flow rates, spermatozoa exhibited […]Ali Karimi
- Clog-free all-aqueous microfluidic fabrication of hydrogel microfibers governed by a universal scaling law Tháng mười một 26, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01007A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinchang Zhu, Yi He, Jing Wang, Isabella Powell, Pu Zhang, Anthony Ouertani, Yong Wang, Liheng CaiHydrogel microfibers provide a versatile platform for cell encapsulation and tissue engineering, but their fabrication typically involves harsh or […]Jinchang Zhu
- Electroporation of spheroids using an electric field gradient: a tool to study intensity-dependent permeabilization Tháng mười một 26, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00613A, PaperThéo Le Berre, Julien Marchalot, Guilhem Rival, Laure Franqueville, Rabia Önbaş, Charlotte Riviere, Gabriel Marcellier, Frédéric Prat, Marie Frénéa-RobinA new microsystem is presented for applying a tunable electric field gradient to a spheroid array. Proof of concept is demonstrated by studying the progressive permeabilisation of the spheroids during electroporation, […]Théo Le Berre
- A physicochemically compatible ferrofluid droplet robotic system for automated bioanalytical assays Tháng mười một 26, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00926J, PaperChristina C. K. Au Yeung, Ruotong Zhang, Chengzhi Zhang, Xiaoxue Fan, Yang Cao, Chi Song, Haisong Lin, Ho Cheung ShumA physicochemically compatible ferrofluid-based droplet robotic platform with high colloidal stability for reliable droplet actuation and high sensitivity and quantification reliability to enable automated assays.To cite this article before page […]Christina C. K. Au Yeung
- Three-dimensional intestinal tube with a crypt-like uneven inner wall fabricated using electrolysis-generated microbubbles Tháng mười một 26, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00766F, PaperShota Uramoto, Shuma Tanaka, Shun Itai, Jumpei Muramatsu, Daichi Arai, Kosuke Tsukada, Takaaki Abe, Takafumi Toyohara, Hiroaki OnoeA 3D intestinal hydrogel tube with a crypt-like inner surface was created using electrolysis-generated microbubbles. Caco-2 cells grew inside, maintaining the structure and forming polarized epithelial layers suitable for biomimetic applications.To cite […]Shota Uramoto
- Lymph node paracortex-inspired on-a-chip recapitulating immunosenescence: a cancer vaccine immunogenicity and antitumoral efficacy screening platform Tháng mười một 24, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00533G, PaperSurjendu Maity, Alireza Hassani Najafabadi, Satoru Kawakita, Danial Khorsandi, Can Yilgor, Christopher Jewell, Neda Mohaghegh, Mehmet Remzi Dokmeci, Ali Khademhosseini, Vadim JucaudThe lymph node paracortex-inspired on-a-chip captures age-dependent T cell responses to cancer vaccine, including antigen presentation, CD8 T cell activation, and antitumoral effector functions, which conventional 2D models […]Surjendu Maity
- Repeated exposure of anticancer agents to tumorspheres in open-surface microwell arrays for modeling chemotherapy-induced dormancy in colorectal cancer Tháng mười một 24, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00453E, PaperHui Kang, Xiaogang Wang, Weijie Ye, Yanzhang Luo, Jueming Chen, Ziqing Ma, Jiayu Li, Lihui Wang, Dongguo Lin, Dayu LiuTumorspheres in open-surface microwell arrays were repeatedly exposed to an anticancer drug combination to investigate the biological responses and dormancy characteristics of colorectal cancer cells within.To cite this article before […]Hui Kang
- Microfluidic-assisted sperm sorter: a high-throughput sperm selection device Tháng mười một 19, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00734H, PaperDhiraj B. Puri, Vadiraj Hemadri, Gautam Biswas, Siddhartha TripathiA high-throughput microfluidic-assisted sperm sorting (MASS) device combining sperm cell rheotaxis and boundary-following behaviour, enables isolation of highly motile and viable sperm cells, outperforming conventional sperm separation techniques.To cite this article before page numbers are assigned, use the DOI form of […]Dhiraj B. Puri
- Multifunctional microfluidic bioelectronic suture for accelerated healing and wound monitoring Tháng mười một 19, 2025Lab Chip, 2025, 25,6582-6592DOI: 10.1039/D5LC00880H, PaperYesol Kim, Chanhui Park, Gi Doo Cha, Sung-Hyuk Sunwoo, Dae-Hyeong KimA multifunctional microfluidic bioelectronic suture enables real-time wound monitoring and electrical stimulation to accelerate healing.The content of this RSS Feed (c) The Royal Society of ChemistryYesol Kim
- Engineering spatially defined extracellular matrix gradients to govern self-organized multicellular aggregates in a glioblastoma-on-a-chip Tháng mười một 18, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01018G, PaperJianing Li, Xinghua Gao, Xiaoling Yang, Hongcai Wang, Xindi Sun, Chang Xue, Jingyun MaA glioblastoma-on-a-chip featuring an engineered spatial ECM gradient was developed to govern self-organized endothelial–glioma multicellular aggregates and enabled the investigation of tumor stem cell differentiation.To cite this article before page numbers are assigned, use the DOI […]Jianing Li
- DCMiC: a double-cylinder micro-chamber platform for high-throughput drug screening and modeling of microenvironmental resistance in Ewing sarcoma Tháng 12 9, 2025
