RSC – Lab Chip latest articles- Bioinspired quality-based sperm sorting in a spiral microfilter-enhanced microfluidic device: enhancing DNA integrity via rheotaxis and boundary dynamics Tháng 4 8, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00427F, PaperDonya Shahhoseini, Naser NaserifarA bioinspired spiral microfluidic device leverages rheotaxis and boundary dynamics for label-free sperm sorting, reducing DNA fragmentation and enhancing viability, providing a practical solution for challenging semen in assisted reproduction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Donya Shahhoseini
- Topology-Based Coordination Control for Multi-Droplet Tasks in Autonomous Digital Microfluidics Tháng 4 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00147E, PaperZhen Gu, kunlun guo, Zerui Song, Boyi Feng, Tiaofen Qiu, Jiale Zhou, Bin Shen, Bingyong Yan, Hui-Feng WangDigital microfluidics (DMF) is a versatile technique for parallel and field-programmable control of individual droplets. The challenge of large-scale parallel droplet manipulation in DMF is essentially a cross-scale complex system...The content of […]Zhen Gu
- Sequential Intracellular Delivery of Genetic Coding Molecules Using an Acoustic Electric Microfluidic Platform Tháng 4 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00941C, PaperMichelle Zhang, Aida Z Taravatfard, Mohammad Aghaamoo, Abraham Phillip LeeIntracellular delivery of genetic coding molecules is a critical step in both fundamental cell biology and the development of cellular and gene therapies. With the emergence of diverse genetic coding...The content of this RSS Feed (c) The Royal Society of […]Michelle Zhang
- High-Throughput Microfluidic Platform for Modelling Inflammatory Responses of Human Articular Chondrocytes under Variable Fluid Shear Stress Tháng 4 7, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01167A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aldeliane Maria da Silva, Priscila C Rodrigues, Meriem Lamghari, Hoang-Tuan Nguyen, Jere Kettunen, Sebastien Mosser, Prateek Singh, Ali Mobasheri, Gabriela LoriteInflammation plays a critical role in osteoarthritis (OA), a debilitating joint disease characterized by […]Aldeliane Maria da Silva
- Correction: Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays Tháng 4 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC90032A, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ali Khademhosseini, Judy Yeh, George Eng, Jeffrey Karp, Hirokazu Kaji, Jeffrey Borenstein, Omid C. Farokhzad, Robert LangerTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Ali Khademhosseini
- Robotic acoustofluidic single-cell picking and placement platform Tháng 4 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01129A, PaperWanqi Li, Qiu Yin, Jiahui Wu, Chenfan Zhang, Xiaochen Li, Chenyang Zhou, Xianting Ding, Xiang ChenSingle-cell manipulation is essential for investigating cellular heterogeneity and enabling downstream assays, such as single-cell proteomics and drug screening.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Wanqi Li
- Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood Tháng 4 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00039H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lewis Krzeczkowski, Georgios Nteliopoulos, Simak Ali, Paul Davey, R. Charles Coombes, Ali Salehi-ReyhaniA microfluidic band-stop filter selectively enriches viable CTC-sized cells from undiluted whole blood while excluding smaller and larger blood cells. Captured cells […]Lewis Krzeczkowski
- A dual-antibody gold nanoparticle-based lateral flow assay for rapid and selective detection of mesenchymal stem cell stemness Tháng 4 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00037A, PaperDrishya Prakashan, C. A. Amarnath, Shilpa N. Sawant, G. Taru Sharma, Sonu GandhiSmartphone readable AuNPs-LFA enables rapid, visual, and qualitative detection of stemness of MSCs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Drishya Prakashan
- Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells Tháng 4 6, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00067C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Louis P Widom, Panteha Torabian, Michelle A Trempel, Molly C McCloskey, Lea Vacca Michel, James L McGrath, Thomas R. GaborskiPathogenic bacterial extracellular vesicles (BEVs) can disrupt the blood-brain barrier (BBB), leading to neuroinflammation. Prior […]Louis P Widom
- Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva Tháng 4 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01063B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ling Ding, Huizi Zhang, Yao Li, Jun KameokaA stitched lyocell–modal microfluidic platform guides saliva to a microneedle-based electrochemical sensor, providing a simple route for low-concentration lactate detection in human saliva.To cite this article before […]Ling Ding
- Cap-Sweat: a capillary microfluidic platform for digitized sweat sampling and time-resolved biomarker analysis Tháng 4 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01172H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pezhman Jalali, Amir Sanati NezhadWearable capillary device for time-resolved sweat analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Pezhman Jalali
- An automated modular microfluidic platform for end-to-end mRNA synthesis and purification Tháng 4 5, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00118A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vikas Sharma, Amirreza Mottafegh, Jeong-Un Joo, Dong-Pyo KimManual, batchwise downstream operations remain a major bottleneck in translating microfluidic mRNA synthesis into practical production workflows. Building on an oscillatory microfluidic IVT module (Os(IVT)) previously established […]Vikas Sharma
- Flow-Programmable and Reversible Surface-Induced LLPS in Nanofluidic Channels Tháng 4 2, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00003G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryoichi Ohta, Zhixin Zhao, Xuan Yan, Ruying Wang, Kazuma MawatariLiquid–liquid phase separation (LLPS) functions as a high-performance reactor strategy in cells, creating dynamic "membrane-less organelles" that selectively concentrate biomolecules. Mimicking this volumetric strategy on […]Ryoichi Ohta
- Low-temperature inkjet-printed electrochemical sensors on OSTE+ microfluidics for oxygen monitoring and scavenging Tháng 4 1, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01117E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Denise Marrero, Ferran Pujol-Vila, Eva Tuset, Gemma Gabriel, Rosa Villa, Mar Alvarez, Xavi IllaPhotonic curing sinters gold and silver nanoparticle inks without damaging polymer substrates. Real-time oxygen scavenging is monitored using electrochemical sensors. Tunable […]Denise Marrero
- Compact Superlattice as Label-free Surface-Enhanced Raman Scattering Substrate for Noninvasive Urine Test in the Diagnosis of Lung Cancer Tháng 4 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01177A, PaperKaili Zhang, Yuancai Ge, Yi Xu, Yujie Liu, Chaoyue Cui, Yuxin Liang, Yangxuan Lin, Jungeng Zhang, Qingwen Zhang, Yi Wang, Xiaoming LinThe development of noninvasive cancer diagnosis may provide the convenience of remote painless diagnosis, instant healthcare and postoperative follow-up. Label-free surface-enhanced Raman spectroscopy (SERS) is becoming as a […]Kaili Zhang
- Numerical microfluidic chip modeling of laminar vortex dynamics induced by biomineralization in evolving porous media Tháng 4 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01002K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yajie Chu, Dianlei FengNaturally evolving porous media, such as those undergoing mineral precipitation, biofilm growth, and freeze-thaw cycling, dynamically alter pore structure, inducing vortices that influence mass transport and mixing. Yet, due to...The content […]Yajie Chu
- Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting Tháng 4 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00072J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alison Skelley, Yasna Behmardi, Luke Peterson, David Inglis, Mabel Shehada, Laurissa Ouaguia, Khushroo Gandhi, Roberto Campos-González, Tony WardAutologous CAR-T cell therapy has demonstrated remarkable clinical efficacy in hematologic malignancies, yet its broader application remains […]Alison Skelley
- Integration of continuous microfluidic electrokinetic bioparticle preconcentration with programmable extraction into a discrete microfluidic platform Tháng 3 30, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00647C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amir Hillman, Sinwook Park, Gilad YossifonIon concentration polarization-based electrokinetic molecular preconcentration in a flowing microchannel, followed by electrowetting-on-dielectric extraction into discrete droplets within an integrated continuous-digital microfluidic platform.To cite this article before page numbers […]Amir Hillman
- A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks Tháng 3 29, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01171J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Delaney Gray-Scherr, Terry Ching, Katherine Beran, Sarah C. Adams, Emily Davis, Abraham C. I. van Steen, Trisha Raman, Wilson W. Wong, Jeroen Eyckmans, Christopher S. ChenA 3D microfluidic platform for studying cross-network transport and […]Delaney Gray-Scherr
- A 3D-Printed Electromagnetically Actuated Microgripper System for Precision Single-Cell Manipulation Tháng 3 27, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00081A, PaperXi Chen, Qingying Ren, Wenshuo Zhao, Minhao Wang, Yining Guo, Jing Huang, Xuhui Zhao, Xinyu Lu, Yuan Liu, Haifeng XuCell manipulation is an important technique in biomedical research, yet existing micromanipulation tools still face challenges in force-control precision, multiscale adaptability, and biocompatibility. To address these limitations, this paper presents...The […]Xi Chen
- Bioinspired quality-based sperm sorting in a spiral microfilter-enhanced microfluidic device: enhancing DNA integrity via rheotaxis and boundary dynamics Tháng 4 8, 2026
