RSC – Lab Chip latest articles- Lossless Altered Histone Modification Analysis System (LAHMAS) July 2, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00060B, PaperZachary J. Kauffman, Kevin Koesser, Kyle T. Helzer, Marina N. Sharifi, Erika Heninger, Chao Li, Duane Juang, David Jarrard, Shuang G. Zhao, Michael C. Haffner, David Beebe, Joshua M Lang, Jamie M SpergerMiniaturized biological assays using microfluidics have the potential to enhance assay sensitivity, reduce reagent consumption, and increase […]Zachary J. Kauffman
- Present and Future of Smart Functional Materials as Actuators in Microfluidic Devices July 1, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00259A, Critical ReviewSepideh Izaddoust, Isabel Poves-Ruiz, Enrique Azuaje-Hualde, Daniel Patko, Larisa Florea, Colm Delaney, Lourdes Basabe-Desmonts, Fernando Benito-LopezThe role of actuators in microfluidic systems is fundamental for accurate measurements and analyses, as they enable precise control over fluid flow by converting various forms of energy—including electrical, thermal,...The content of this […]Sepideh Izaddoust
- Monitoring the mechanical responses of tumor metastasis based on a microfluidic chip integrated with an electrochemical detection system July 1, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00563A, PaperShuqi Chen, Hang Qi, Yuanheng Kuang, Quanning Li, Xuejiao Chen, Yanyan WangSpatial confinement and fluid shear stress collectively regulate the morphology, migration patterns and migratory velocity of tumor cells, further influencing the impedance of tumor cells.To cite this article before page numbers are assigned, use the DOI form of […]Shuqi Chen
- Magnetic–enzymatic synergy driven photoelectrochemical aptasensor on a microfluidic chip for sub-pM kanamycin detection July 1, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00450K, PaperYuchen Shen, YunYi Shi, Juan WangA smartphone-integrated microfluidic photoelectrochemical aptasensor enables automated, sub-pM kanamycin detection via enzymatic–magnetic cascaded amplification and wireless readout.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYuchen Shen
- REFRACTIVE INDEX SENSING IN A MONOLITHIC MICRO-OPTOFLUIDIC LITHIUM NIOBATE CHIP June 30, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00074B, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniel Tochi Nwatu, Sergiy Suntsov, Detlef Kip, Kore HasseLithium niobate is an outstanding material for the realization of fully integrated lab on a chip devices due to its variety of physical properties, such as […]Daniel Tochi Nwatu
- Exploring Neuronal Circuitry in Neurodegenerative Diseases: from traditional models to cutting-edge techniques June 30, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00125K, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chiara Ausilio, Annachiara Scalzone, PAOLO Antonio NETTICurrent treatments of neurodegenerative diseases primarily address symptoms rather than halting pathology progression. This gap is due to the lack of effective methods for monitoring neural circuitry and […]Chiara Ausilio
- Size analysis of large DNA molecules by relaxation time measurement using a nanoslit channel June 30, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00998C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hongdong Yi, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang, Naoki AzumaA relaxation-time-based approach using 49 nm-deep nanoslits enables precise size identification of DNA molecules >10 kbp, achieving a resolution of 2.33 in 60 seconds.To cite […]Hongdong Yi
- In-Petri-dish acoustic vortex tweezers June 30, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00799A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Teng Li, Yingshan Du, Bowen Cai, Michael R. Brooks, Chongpeng Qiu, Zhide Wang, Jiali Li, Luyu Bo, Y. Albert Pan, Zhenhua TianThis study presents an acoustic vortex tweezers platform that enables contactless, precise, multi-degree-of-freedom, […]Teng Li
- Utilizing layer-parameter of shear horizontal surface acoustic wave biosensor for lipoprotein particle sizing June 30, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00444F, PaperChia-Hsuan Cheng, Hiromi Yatsuda, Jun KondohA 250 MHz reflective SH-SAW biosensor uses velocity-to-attenuation ratio to distinguish lipoprotein sizes. This 3 × 5 mm chip enables label-free plasma testing for rapid point-of-care cardiovascular risk assessment.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Chia-Hsuan Cheng
- A hand-operated microfluidic sample preparation-to-analysis workflow for simplifying the basophil activation test June 26, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00037H, PaperNicolas Castaño, Kaiser Chua, An Nguyen, Wyeth Marshall, Grady H. Hofmann, Jonathan Lee, Mindy Tsai, Sayantani B. Sindher, Kari C. Nadeau, R. Sharon Chinthrajah, Stephen J. Galli, Sindy K. Y. TangμF-prep simplifies basophil activation tests withNicolas Castaño
- Spheroid-based skin-on-a-chip platform for the evaluation of the toxicity of small molecules and nanoparticles June 25, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00311C, PaperDianoosh Kalhori, Faeze Rakhshani, Yingshan Ma, Ilya Yakavets, Sina Kheiri, Ophelie Zeyons, Susanne N. Kolle, Ted Deisenroth, Liangliang Echo Qu, Zhengkun Chen, Eugenia KumachevaExposure of human skin to chemical agents may lead to skin sensitization, irritation, and corrosion. Time-efficient toxicity screening can be achieved using in vitro skin-on-a-chip models, […]Dianoosh Kalhori
- Polyarginine-functionalized AP site probes for mechanistic analysis of uracil–DNA glycosylase via nanopore-based single-molecule sensing June 25, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00388A, PaperTing Li, Shaojiao Song, Wei Lu, Xin Zheng, Hui Tian, Yu Cao, Qiuyue Zhao, Hongying Xie, Jiexin Zheng, Hailong WangDNA–R5, a novel synthetic DNA adduct was introduced by covalently conjugating AP sites with a polyarginine-5 (R5) peptide for sensitive detection of uracil DNA glycosylase (UDG) activity.To cite this article […]Ting Li
- Statistical distribution of elevation from a planar interface of phoretically active microparticles June 24, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC01092B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Fabian Rohne, Daniela Vasquez Munoz, Isabel Meier, Nino Lomadze, Svetlana Santer, Marek BekirIn this article, we study the height distribution of phoretically active microparticles exposed to external flow. Sedimented particles hover under light illumination […]Fabian Rohne
- Portable platform for measuring amyloid beta 42/40 ratio via photooxidation-induced fluorescence amplification June 22, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00235D, PaperSanghag Ko, Hyunjun Bae, Daewon Kim, Yeonju Lee, Isaac Choi, Dain Lee, Dong hwan Choi, Hyung Chul Kim, Seo Young Sohn, Yohan Jeong, Seok Chung, Young Hee JungWe developed a portable immunoassay platform using photooxidation-induced fluorescence amplification to measure Aβ 42/40 in plasma, offering a more accessible alternative to […]Sanghag Ko
- Orientation-independent bubble trap with internal partition for robust operation of microfluidic systems June 22, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC01060D, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bhavagyna Vegunta, Charmaine Lui, Max Kim, Joshua Tran, Maya Papez, Anand K. Ramasubramanian, Sang-Joon John LeeThe bubble trap has a spherical cavity and a partition with internal passages. Ingress and egress ports near the […]Bhavagyna Vegunta
- Micro-/nanoparticle separation combining inertial and thermophoretic effects in three-dimensional serpentine-spiral channels June 19, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00420A, PaperJunho Kim, Hwisu Jeon, Kyunghun Lee, Taesung KimWe present a 3D serpentine-spiral microfluidic device that simultaneously induces Dean flow and a radial temperature gradient, coupling inertial and thermophoretic forces.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Junho Kim
- Advancing sustainable energy solutions with microfluidic porous media June 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00206K, Critical ReviewWenhai Lei, Yuankai Yang, Shuo Yang, Ge Zhang, Jenna Poonoosamy, Anne Juel, Yves Méheust, Shervin Bagheri, Moran WangMultiphase reactive flow in sustainable energy solutions (CCS, UHS, NWGD), coupling the multiphase flow, reactive transport, and microbial activities. The internal schematic diagram is the subsurface storage of CO2, H2, and […]Wenhai Lei
- Analysis of and methods for void-free liquid filling of blind microchambers in centrifugal microfluidics June 16, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00323G, PaperWeiyao Ni, Yi Gao, Enming Cui, Yifei Li, Yangyang Wang, Yahua Liu, Yi Li, Mengxi Wu, Junshan LiuTapered microchannels modify the gas–liquid flow to the annular regime, enabling void-free filling of blind microchambers without the need for complex treatments or external forces.To cite this article before page numbers are […]Weiyao Ni
- Functional screening of antibody-secreting cells by co-culture with reporter T cells using PicoShells June 15, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00319A, PaperKazuki Nishimoto, Rajesh Ghosh, Mark van Zee, Darren Fang, Zhiyuan Mao, Miyako Noguchi, Dino Di CarloAntibody secreting cells (ASCs) and reporter T cells are co-cultured in PicoShells, hollow hydogel particles. T cell-activating antibodies are identified via reporter signals using standard FACS, enabling recovery of high-functioning ASCs.To cite this article […]Kazuki Nishimoto
- Vascular microphysiological systems (MPS): biologically relevant and potent models June 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00014A, Critical ReviewLucas Breuil, Atsuya Kitada, Sachin Yadav, Hang Zhou, Kazuya Fujimoto, Ryuji YokokawaExtensive research focused on the vasculature, aiming to understand its structural characteristics, functions, interactions with surrounding tissues, and the mechanisms underlying vascular-related pathologies. However, advancing our understanding of vascular biology...The content of this RSS Feed (c) The […]Lucas Breuil
- Lossless Altered Histone Modification Analysis System (LAHMAS) July 2, 2025
