RSC – Lab Chip latest articles- Microfluidic insights into microbial impacts on hydrogen flow in underground hydrogen storage May 17, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00206D, PaperYuyi Liu, Diansen YangUnderground hydrogen storage, involving periodic injection and extraction of hydrogen gas, serves as a crucial approach for achieving energy peak shaving and accommodating large-scale renewable energy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Yuyi Liu
- 3D printing monolithic, multifunctional polymer acoustofluidic devices with tunable mixing and particle focusing May 14, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00107F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Roxanne Kate Balanay, Justin W. Yip, Justin Do, Omair Adil, Keith Johnson, Tyler R. RayAcoustic forces offer a powerful, contact-free modality for manipulating particles and fluids within microfluidic lab-on-a-chip systems.To cite this article before […]Roxanne Kate Balanay
- Droplet microfluidic profiling of NK cell cytotoxicity with machine learning-enabled target-cell death analysis May 12, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00301J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rana S. Ozcan, Fatemeh Vahedi, Shina Namakian, Ali A. Ashkar, Tohid F. DidarA droplet microfluidic workflow combines ML-based K562 death analysis with manual NK annotation to quantify attachment, killing, serial killing, and killing-time differences […]Rana S. Ozcan
- A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates May 12, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00143B, PaperAvi Gupta, Jacqueline van Zyl, Collin Bushey, Hoseyn Amiri, Peter Shankles, Guillem Pratx, Alexander Alexeev, Todd SulchekEfficient and reproducible intracellular delivery is critical for manufacturing next generation cell therapies. Mechanoporation employs mechanical forces, including shear loading, adhesion, and compressive strain, to transiently permeabilize cell membranes and...The content of this […]Avi Gupta
- Creating an improved workflow for paper-based malaria diagnostics by integrating total lysis of whole blood May 12, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00145A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.J. Prat-Trunas, A. Code, Y. Avalos-Padilla, X. Fernández-Busquets, C. R. Mace, E. BaldrichThree-dimensional paper-based lysis device fabricated by laser cutting or by wax printing that achieves 100% cellular lysis independent of sample composition, facilitating […]J. Prat-Trunas
- Integrated Microfluidic Biosensors: Shaping the Future of Quantitative Life Sciences and On-Chip Molecular Diagnostics May 12, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00957J, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ty Naquin, Chloe Naquin, Qian Wu, Ying Chen, Aidan J Canning, Kaichun Yang, Yuna Li, Shuaiguo Zhao, Yun Ling, Zhiteng Ma, Ke Jin, Ye He, Shujie Yang, Luke P. Lee, Tony Jun HuangIntegrated […]Ty Naquin
- Yield stress fluids in microfluidics: research, applications and opportunities May 11, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00864F, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hossein Rahmani, Seyed Mohammad TaghaviMicrofluidic technologies support diverse biomedical and environmental applications, many of which involve complex fluids whose non-Newtonian rheology governs small-scale transport, mixing, and interfacial dynamics.To cite this article before page […]Hossein Rahmani
- Local chemotactic response of Escherichia coli in fluid and near surfaces May 11, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01048A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Gargasson, Julien Bouvard, Carine Douarche, Peter Mergaert, Harold AuradouBacteria can adjust their swimming behaviour in response to chemical variations, a phenomenon known as chemotaxis. This process is characterised by a drift velocity that […]Adam Gargasson
- Point-of-care SERS platforms: integrating microfluidics and machine learning for disease screening May 11, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00202A, Critical ReviewBiqing Chen, Xiaohong Qiu, Yang LiMicrofluidic SERS platforms enable ultrasensitive, high-throughput bioanalysis via Raman enhancement and microfluidic control. Plasmonic integration supports multiplexed biomarker detection for biomedical research and clinical translation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Biqing Chen
- 3D stamp-integrated open-top microfluidic organ-on-a-chip for high-fidelity and functional reconstruction of vascularized microtissue models May 11, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00096G, PaperChenyang Zhou, Feifan Wang, Jiaqi Xu, Aochen Wang, Hanping Song, Luyao Wei, Guoxiang Fu, Xiaolin WangThe limited physiological relevance of current organ-on-a-chip models often stems from an inability to integrate organspecific tissue architectures with functional vascularization. Here, we introduce an open-top microfluidic platform that integrates...The content of this RSS […]Chenyang Zhou
- Exploring paclitaxel–albumin-loaded neutrophil-like cells via microfluidic-based mechanical deformation for enhanced cargo delivery in glioblastoma therapy May 11, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01140J, PaperDaidi Zhou, Xinghua Gao, Zhiyu Mao, Xiaoling Yang, Jingyun Ma, Ekaterina Andreevna Vorotelyak, Guohui Hu, Fengping Zhu, Jinbo WuThis study investigated the rapid drug delivery capabilities of neutrophil-like cells using a microfluidic chip-based mechanical deformation approach, with an emphasis on glioblastoma treatment at the cellular level.To cite this article […]Daidi Zhou
- A portable modular acoustic streaming vortex platform for flexible and robust fabrication of monodisperse micromaterials May 10, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00054A, PaperXiaoping Miao, Tianao Chen, Jijie Fu, Shilu Zhu, Mei Lan, Huayi Fu, Zhiqiang Zhu, Mingzhai Sun, Ronald X. XuA modular acoustic streaming vortex (MASV) platform has been developed for off-chip production of monodisperse microdroplets with broad size tunability and versatile viscoelastic properties.To cite this article before page numbers are […]Xiaoping Miao
- Thin stencil membrane-assisted high throughput single-cell to cluster of cells micropatterning and large-size biomolecular transfection in primary and stem cells May 10, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00164E, PaperDonia Dominic, Srabani Kar, Rajdeep Ojha, Moeto Nagai, Tuhin Subhra SantraSchematic illustration of high-throughput biomolecular delivery in single-cell patterns. Pulsed laser scanning-activated photoporation mediated through a micropatterned rGO device facilitates intracellular delivery in cell micropatterns.To cite this article before page numbers are assigned, use the DOI form of citation […]Donia Dominic
- Automation-assisted human skin-on-a-chip for modeling ultraviolet-induced injury and evaluating photoprotective and regenerative modalities May 10, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00134C, PaperYu-Jeong Lee, Jieun Lee, Yoojin Na, Hoon Suk Rho, Min-Kyu Kang, YongTae Kim, Jeong-Kee YoonAn automation-assisted human skin-on-a-chip platform integrating epidermal and dermal monolayers was developed to model UVB-induced skin injury and to evaluate photoprotective (ZnO and BP-3) and regenerative (iMSC-derived nanovesicle) modalities.To cite this article before page numbers […]Yu-Jeong Lee
- Multiplexed nanophotonic biosensing and deep learning-driven protein quantification for traumatic brain injury diagnosis at the point of care May 10, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01079A, PaperJiayu Liu, Yuxin Wang, Shichao Su, Meng Su, Wenying Lv, Zhao Gao, Congwei Liu, Yanteng Li, Junzhao Sun, Peng Wang, Baorui Guo, Fan Yang, Renke He, Yanlin Song, Zeying Zhang, Jianning Zhang, Gang ChengThis integrated nanophotonic biosensor platform enables multiplex detection of TBI biomarkers through an end-to-end process, offering […]Jiayu Liu
- Quantitative Rapid Tests for Urine Creatinine via Fenton’s Reaction and Self-Driven Microfluidic Devices May 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00249H, PaperHogi Hartanto, Jiaheng Li, Cheuk Chun Szeto, Ting-Hsuan ChenUrine creatinine plays a pivotal role both as an indicator for kidney impairments as well as a normalizer for other urine markers to account for the variance of urine volume....The content of this RSS Feed (c) The Royal Society of ChemistryHogi Hartanto
- Learning-aided design of micropost arrays for optimizing interface stability and mass transport in organs-on-chips May 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01180A, PaperDaeho Kim, Suhwan Lee, Suyoen Kim, Yoojeong Noh, Eunseop Yeom, Song Ih AhnLearning-aided design of micropostMicropost-based organ-on-a-chip (OOC) platforms are widely used to spatially confine cell-laden hydrogels and create three-dimensional (3D) co-culture microenvironments while maintaining adjacent channels for mass transport, drug delivery,...The content of this RSS Feed (c) The […]Daeho Kim
- High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform May 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01050K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander Bevacqua, Do Hyun Park, Sheryar Khan, Qingxuan Li, Mahsa Hadidi, Jianzhu Chen, Jongyoon HanA 25-layer spiral microfluidic device significantly reduces cell biomass from high-turbidity feedstock using inertial focusing to perform primary clarification and […]Alexander Bevacqua
- Acoustofluidic Separation of Oblate Spheroid from Sphere using Acoustic Radiation Torque and Force May 6, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00140H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Muhammad Soban Khan, Mushtaq Ali, Yong Bin Bang, Seong Jae Lee, Jinsoo ParkCells, bacteria, and other bioparticles exist in diverse shapes, and their morphology plays a pivotal role in biological functions and clinical significance. […]Muhammad Soban Khan
- Lab-on-a-Chip Systems for Microplastic and Nanoplastic Sampling, Detection, Characterization and Bioassessment May 6, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00116E, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Liyuan Gong, Erfan Eskandari, Md Iftakhar Khan, Yang LinMicroplastics (MPs) and nanoplastics (NPs) are ubiquitous environmental contaminants, with growing evidence of their ecological and human health risks. However, a clear understanding of their […]Liyuan Gong
- Microfluidic insights into microbial impacts on hydrogen flow in underground hydrogen storage May 17, 2026
