RSC – Nat. Prod. Rep. latest articles- The isolation, biosynthesis, biological profiles and synthesis of the pterocarpans, pterocarpenes and coumestans: isoflavone derivatives with pharmacological utility March 26, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00007J, Review ArticleLiangguang (Jack) Yi, Lorenzo V. White, Martin G. BanwellThe title compounds are three structurally related classes of isoflavone that often act as phytoalexins in the producing plants. This review highlights their biological profiles that make them ongoing targets for synthesis and drug development.To cite this article before […]Liangguang (Jack) Yi
- Charting the path for L-tyrosine derivatives: from engineering strategies to microbial cell factories March 24, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00091B, Review ArticleLi Zhou, Xulei Shi, Hui Jiang, Yuanyuan Xia, Haiquan Yang, Wei Shen, Yu Cao, Xianzhong ChenReview highlights cutting-edge advances in producing L-tyrosine derivatives via tyrosol, p-coumaric acid, and L-DOPA nodes in E. coli and yeast.To cite this article before page numbers are assigned, use the DOI form […]Li Zhou
- Highlights of cyanobacterial metabolites reported between 2021–2024 March 16, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00076A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Simon Sieber, Elisabeth M.-L. JanssenThis review provides an overview of newly identified cyanobacterial metabolites from 2021 to 2024. The discovery of specific natural products is discussed.To cite this article before page numbers […]Simon Sieber
- Glucose 6-phosphate: the diversity of C-methylation in sugar moieties within natural product biosynthesis March 16, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00071H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ziruo Zou, Michael MüllerDiverse methylation of sugar units by SAM-dependent C-methyltransferases in natural product biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Ziruo Zou
- Decision making by modular polyketide synthases and implications for genetic engineering March 13, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00010J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kira J. WeissmanThis review details the many choices underlying faithful biosynthesis of complex polyketides in bacteria, and highlights the implications for genetic engineering aiming to generate novel derivatives.To cite this article before […]Kira J. Weissman
- Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computational NMR method March 10, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00088B, HighlightSrinivas Beduru, Andrei G. KutateladzeThis Highlight article describes a personal selection of recent misassigned structures of NPs and their revision with the aid of DU8ML, an ML-augmented DFT method for fast and accurate calculations of NMR parameters, mostly covering 2018 to 2025.To cite this article before page numbers […]Srinivas Beduru
- Quinic acid as a chiron in total synthesis March 3, 2026Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00087D, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manuel J. Verganista, Iago C. Vogel, Nuno R. CandeiasQuinic acid is a versatile chiral building block in asymmetric synthesis, enabling diverse natural products and bioactive compounds. This review highlights four decades of […]Manuel J. Verganista
- Synthetic biology for heterologous expression and engineering of fungal polyketide synthases March 2, 2026Nat. Prod. Rep., 2026, 43,401-414DOI: 10.1039/D5NP00020C, HighlightSidharth Jayachandran, Adrian Enrique Gadar-Lopez, Ling Chen, Kasper Krunderup Jakobsen, Coco Xie, Therese Horch, Jay D. Keasling, Pablo Cruz-MoralesPolyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products.The content of this RSS Feed (c) The Royal Society of ChemistrySidharth Jayachandran
- Trimeric natural products: structural diversity, biosynthesis, bioactivities and chemical synthesis January 22, 2026Nat. Prod. Rep., 2026, 43,462-496DOI: 10.1039/D5NP00065C, Review ArticleHidayat Hussain, Satyajit D. Sarker, Lutfun Nahar, Ishtiaq AhmedThis review highlights structural diversity, biosynthesis, biomimetic synthesis, and biological functions of trimeric natural products. These biosynthetic pathways could lead to the discovery of more bioactive trimers through (bio)synthesis.The content of this RSS Feed (c) The Royal Society of ChemistryHidayat Hussain
- Discovery, engineering, and applications of amino acid and peptide prenyltransferases January 2, 2026Nat. Prod. Rep., 2026, 43,415-426DOI: 10.1039/D5NP00075K, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Florian HubrichThis review highlights advances in the field of amino acid and peptide prenyltransferases, underscoring their value for chemoenzymatic peptide late-stage functionalization and drug development and showcasing their scope, promiscuity and engineering.The content of […]Florian Hubrich
- Microbial skeletal editing: hints for arene reconstruction from actinobacteria December 22, 2025Nat. Prod. Rep., 2026, 43,518-546DOI: 10.1039/D5NP00078E, Review ArticleViktoria A. Ikonnikova, Vera A. Alferova, Anastasiya Yu. Frolova, Mikhail S. Baranov, Andrey A. MikhaylovThis review surveys skeletal editing in actinobacteria, linking enzyme-driven diversification to modern synthetic analogues and outlining biomimetic strategies that translate natural logic into practical chemical tools.The content of this RSS Feed (c) The Royal […]Viktoria A. Ikonnikova
- Biosynthesis of invertebrate-derived natural products: an uncharted territory December 22, 2025Nat. Prod. Rep., 2026, 43,547-575DOI: 10.1039/D5NP00056D, Review ArticleFeng Li, Chengyu Zhou, Yinhao Wang, Mengmeng Yu, Jianhua JuInvertebrates are a major source of natural products. Their significant biosynthetic potential, revealed by recent studies, is summarized in this review as a reference for future research.The content of this RSS Feed (c) The Royal Society of ChemistryFeng Li
- From diet to defence: ingestion, sequestration, biotransformation, and therapeutic potential of natural products in nudibranch predator–prey interactions December 17, 2025Nat. Prod. Rep., 2026, 43,497-517DOI: 10.1039/D5NP00058K, Review ArticleLauren Gris, Michèle R. PrinsepThis review focuses on the chemoecological interactions reported between nudibranchs and their marine invertebrate prey, highlighting the ingestion, sequestration and biotransformation of diet-derived natural products and their bioactivities.The content of this RSS Feed (c) The Royal Society of ChemistryLauren Gris
- Halogenases and dehalogenases: mechanisms, engineering, and applications November 3, 2025Nat. Prod. Rep., 2026, 43,427-461DOI: 10.1039/D5NP00055F, Review ArticleJing Luo, Na Li, Jia Wang, Yaojie Gao, Hongzhi Tang, Linquan Bai, Sang Yup Lee, Yaojun TongHalogenases and dehalogenases are ubiquitous biocatalysts that mediate halogen incorporation and removal. Synthetic biology is reshaping their catalytic landscapes to unlock new functions and applications.The content of this RSS Feed (c) The […]Jing Luo
- The isolation, biosynthesis, biological profiles and synthesis of the pterocarpans, pterocarpenes and coumestans: isoflavone derivatives with pharmacological utility March 26, 2026
