RSC – Nat. Prod. Rep. latest articles- Correction: Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ October 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP90039E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel JasparsTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Federica Casolari
- Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis September 30, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00052A, Review ArticleBodou Zhang, Jingwen Zhao, Sheng Li, Hong Liang, Xiaojiang Hao, Yu ZhangThis review comprehensively outlines 135 natural ryanodane diterpenes (1948–2025), covering their botanical sources, structural diversity, chemical synthesis, and key bioactivities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Bodou Zhang
- Hot off the Press September 30, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP90038G, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as aragezolone from Auricularia cornea.To cite this article before page numbers are assigned, use the DOI form […]Robert A. Hill
- Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives September 29, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00045A, Review ArticleMartinus de Kruijff, Sebastian Götze, Christine BeemelmannsMetallophores are vital for microbial survival as they mediate metal bioavailability. Yersiniabactin-type metallophores are unique in biosynthesis and structure, with specialized functions that support immune evasion, nutrient acquisition, and niche colonization.To cite this article before page numbers are assigned, use the […]Martinus de Kruijff
- Engineering microbiomes for natural product discovery and production September 23, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00038F, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francesco Del Carratore, Rainer BreitlingThe exciting advancements in multi-omics, genetic engineering and computational tools are paving the way for the engineering of synthetic communities for the discovery and production of natural products. Created […]Francesco Del Carratore
- Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides July 15, 2025Nat. Prod. Rep., 2025, 42,1622-1638DOI: 10.1039/D5NP00042D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shumpei AsamizuThis highlight focuses on the recent advances in the discovery and biosynthesis of bioactive lipopeptide natural products derived from ribosomally synthesized and post-translationally modified peptides.The content of this RSS Feed (c) The […]Shumpei Asamizu
- Natural products targeting the metabolism of amino acids: from discovery to synthetic development July 10, 2025Nat. Prod. Rep., 2025, 42,1575-1621DOI: 10.1039/D5NP00039D, Review ArticleHyun Su Kim, Ahmed H. E. Hassan, Kyuho Moon, Jaehoon SimAmino acid metabolism is essential to homeostasis, immune regulation, and disease. This review highlights natural products that modulate these metabolic pathways and outlines synthetic strategies to enhance their therapeutic potential.The content of this RSS Feed (c) The Royal […]Hyun Su Kim
- Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications June 26, 2025Nat. Prod. Rep., 2025, 42,1489-1506DOI: 10.1039/D5NP00027K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D. Keasling, Byung-Kwan ChoSynthetic protein interfaces enable programmable assembly of PKS and […]Gahyeon Kim
- The ballet of nature: the interconvertible isomerisation of natural products June 22, 2025Nat. Prod. Rep., 2025, 42,1548-1574DOI: 10.1039/D5NP00019J, Review ArticleZe-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang LouThis review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers found in nature, including positional, tautomeric, geometric, optical, and conformational isomerism.The content of this RSS Feed (c) The Royal Society of ChemistryZe-Jun Xu
- Natural products in antiparasitic drug discovery: advances, opportunities and challenges June 11, 2025Nat. Prod. Rep., 2025, 42,1419-1458DOI: 10.1039/D5NP00007F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaofei Shang, Lixia Dai, Xinyuan Cao, Yudong Ma, Ilgekbayeva Gulnaz, Xiaolou Miao, Xiuhui Li, Xiaorong YangIn this review, we discuss the strategies used for developing drugs from natural resources and mainly describe the […]Xiaofei Shang
- Exploring microbial natural products through NMR-based metabolomics June 11, 2025Nat. Prod. Rep., 2025, 42,1459-1488DOI: 10.1039/D4NP00065J, Review ArticleDe-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng WuNMR-based metabolomics—whether applied independently or harmonized with genomics—offers a potent lens into microbes' chemical repertoire. The judicious integration of artificial intelligence (AI) further amplifies the potential of this advanced methodology, ushering in new frontiers for microbial natural […]De-Gao Wang
- Trends in metabolite discovery from Actinomycetes June 8, 2025Nat. Prod. Rep., 2025, 42,1533-1547DOI: 10.1039/D4NP00075G, Review ArticlePaolo Monciardini, Matteo Simone, Marianna Iorio, Sonia I. Maffioli, Margherita Sosio, Stefano DonadioActinomycetes continue to provide new molecules at a steady rate. Here we analyze the contribution of four approaches to the discovery of new metabolites, and which strategies are more effective at yielding structurally original molecules.The content […]Paolo Monciardini
- Technological developments driving industrial natural product discovery June 3, 2025Nat. Prod. Rep., 2025, 42,1507-1532DOI: 10.1039/D4NP00072B, Review ArticleRichard Lewis, Richard Hammond, Mark Wilkinson, Nick AllenbyA new era of antimicrobial discovery: reviewing the limits of traditional methods and the potential for new techniques to discover from previously inaccessible biosynthetic diversity.The content of this RSS Feed (c) The Royal Society of ChemistryRichard Lewis
- Correction: Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ October 8, 2025
