RSC – Nat. Prod. Rep. latest articles- Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis October 20, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00050E, Review ArticleDian Jiao, Yibo Zhang, Wending Guo, Shuang Liu, Ping Su, Luqi HuangThis review highlights the therapeutic potential of cardiac glycosides and emerging chemical synthesis and biosynthesis strategies to overcome supply limitations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Dian Jiao
- A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids October 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00053J, Review ArticleMarcel Kulike-Koczula, Dominik Heimann, Tobias Eulberg, Daniel Kohnhäuser, Roderich D. Süssmuth, Mark BrönstrupThis article summarizes insights on a new class of antibiotics defined by albicidins and cystobactamids. It presents their biosynthesis, total synthesis and lead optimization, the mechanisms of action and resistance, and the antibiotic properties.To cite […]Marcel Kulike-Koczula
- Correction: Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ October 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP90039E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel JasparsTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Federica Casolari
- Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis September 30, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00052A, Review ArticleBodou Zhang, Jingwen Zhao, Sheng Li, Hong Liang, Xiaojiang Hao, Yu ZhangThis review comprehensively outlines 135 natural ryanodane diterpenes (1948–2025), covering their botanical sources, structural diversity, chemical synthesis, and key bioactivities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Bodou Zhang
- Hot off the Press September 30, 2025Nat. Prod. Rep., 2025, 42,1646-1650DOI: 10.1039/D5NP90038G, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as aragezolone from Auricularia cornea.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives September 29, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00045A, Review ArticleMartinus de Kruijff, Sebastian Götze, Christine BeemelmannsMetallophores are vital for microbial survival as they mediate metal bioavailability. Yersiniabactin-type metallophores are unique in biosynthesis and structure, with specialized functions that support immune evasion, nutrient acquisition, and niche colonization.To cite this article before page numbers are assigned, use the […]Martinus de Kruijff
- Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products July 31, 2025Nat. Prod. Rep., 2025, 42,1717-1746DOI: 10.1039/D5NP00030K, Review ArticleJi-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong ZhangAlkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms.The content of this RSS Feed (c) The Royal Society of ChemistryJi-Wei Sang
- para-Quinone methides in natural product biosynthesis July 31, 2025Nat. Prod. Rep., 2025, 42,1676-1689DOI: 10.1039/D5NP00044K, HighlightJie Gao, Qibin Chen, Qi ZhangThis highlight focuses on nature's strategic use of highly reactive para-quinone methides (p-QMs) as key intermediates in natural product biosynthesis.The content of this RSS Feed (c) The Royal Society of ChemistryJie Gao
- Semi-synthesis in the exploration of opioid-targeting natural products July 29, 2025Nat. Prod. Rep., 2025, 42,1664-1675DOI: 10.1039/D5NP00029G, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrew P. RileyChemically modifying a natural product can be a powerful tool for studying and optimizing its biological activity. This highlight presents recent examples of applying this approach to investigate natural products that target […]Andrew P. Riley
- Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions July 27, 2025Nat. Prod. Rep., 2025, 42,1690-1716DOI: 10.1039/D5NP00028A, Review ArticleRui Liu, Xiao-Ping Peng, David J. Newman, Diane Purchase, Gang Li, Souvik KusariThis review offers a comprehensive analysis of epigenetics and its crucial role in the production of secondary metabolites by endophytic fungi. Strategic epigenetic modulation could enhance drug discovery initiatives involving fungal endophytes.The content of this RSS […]Rui Liu
- Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity July 7, 2025Nat. Prod. Rep., 2025, 42,1651-1663DOI: 10.1039/D5NP00008D, HighlightYuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu, Yihua ChenDiscovery methods of microbial natural products (NPs) evolve with technological progress. This highlight article focuses on representative methods that achieve targeted mining by simultaneously predicting the structure and activity of NPs.The content of this […]Yuwei Zhang
- Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis October 20, 2025
