RSC – Nat. Prod. Rep. latest articles- Glycosylated mycotoxins: a hidden enemy November 3, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00057B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Milena Stránská, Tomáš Řezanka, Vladimír KřenComprehensive review of glycosylated mycotoxins in the food chain: their formation, analytical challenges, health effects and toxicology, synthetic methods, deglycosylation strategies, and regulatory aspects.To cite this article […]Milena Stránská
- Halogenases and dehalogenases: mechanisms, engineering, and applications November 3, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00055F, Review ArticleJing Luo, Na Li, Jia Wang, Yaojie Gao, Hongzhi Tang, Linquan Bai, Sang Yup Lee, Yaojun TongHalogenases and dehalogenases are ubiquitous biocatalysts that mediate halogen incorporation and removal. Synthetic biology is reshaping their catalytic landscapes to unlock new functions and applications.To cite this article before page numbers […]Jing Luo
- Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches October 28, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00022J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Eleni V. Mikropoulou, Aikaterini Basdeki, Maria HalabalakiThis review investigates the journey of metabolite identification and quantification of natural products (NPs), exploiting mass spectrometry approaches from the early 1980s to the current developments […]Eleni V. Mikropoulou
- Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis October 20, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00050E, Review ArticleDian Jiao, Yibo Zhang, Wending Guo, Shuang Liu, Ping Su, Luqi HuangThis review highlights the therapeutic potential of cardiac glycosides and emerging chemical synthesis and biosynthesis strategies to overcome supply limitations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Dian Jiao
- A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids October 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00053J, Review ArticleMarcel Kulike-Koczula, Dominik Heimann, Tobias Eulberg, Daniel Kohnhäuser, Roderich D. Süssmuth, Mark BrönstrupThis article summarizes insights on a new class of antibiotics defined by albicidins and cystobactamids. It presents their biosynthesis, total synthesis and lead optimization, the mechanisms of action and resistance, and the antibiotic properties.To cite […]Marcel Kulike-Koczula
- Hot off the Press September 30, 2025Nat. Prod. Rep., 2025, 42,1646-1650DOI: 10.1039/D5NP90038G, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as aragezolone from Auricularia cornea.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products July 31, 2025Nat. Prod. Rep., 2025, 42,1717-1746DOI: 10.1039/D5NP00030K, Review ArticleJi-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong ZhangAlkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms.The content of this RSS Feed (c) The Royal Society of ChemistryJi-Wei Sang
- para-Quinone methides in natural product biosynthesis July 31, 2025Nat. Prod. Rep., 2025, 42,1676-1689DOI: 10.1039/D5NP00044K, HighlightJie Gao, Qibin Chen, Qi ZhangThis highlight focuses on nature's strategic use of highly reactive para-quinone methides (p-QMs) as key intermediates in natural product biosynthesis.The content of this RSS Feed (c) The Royal Society of ChemistryJie Gao
- Semi-synthesis in the exploration of opioid-targeting natural products July 29, 2025Nat. Prod. Rep., 2025, 42,1664-1675DOI: 10.1039/D5NP00029G, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrew P. RileyChemically modifying a natural product can be a powerful tool for studying and optimizing its biological activity. This highlight presents recent examples of applying this approach to investigate natural products that target […]Andrew P. Riley
- Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions July 27, 2025Nat. Prod. Rep., 2025, 42,1690-1716DOI: 10.1039/D5NP00028A, Review ArticleRui Liu, Xiao-Ping Peng, David J. Newman, Diane Purchase, Gang Li, Souvik KusariThis review offers a comprehensive analysis of epigenetics and its crucial role in the production of secondary metabolites by endophytic fungi. Strategic epigenetic modulation could enhance drug discovery initiatives involving fungal endophytes.The content of this RSS […]Rui Liu
- Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity July 7, 2025Nat. Prod. Rep., 2025, 42,1651-1663DOI: 10.1039/D5NP00008D, HighlightYuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu, Yihua ChenDiscovery methods of microbial natural products (NPs) evolve with technological progress. This highlight article focuses on representative methods that achieve targeted mining by simultaneously predicting the structure and activity of NPs.The content of this […]Yuwei Zhang
- Glycosylated mycotoxins: a hidden enemy November 3, 2025
