RSC – Nat. Prod. Rep. latest articles- Natural products targeting the metabolism of amino acids: from discovery to synthetic development July 10, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00039D, Review ArticleHyun Su Kim, Ahmed H. E. Hassan, Kyuho Moon, Jaehoon SimAmino acid metabolism is essential to homeostasis, immune regulation, and disease. This review highlights natural products that modulate these metabolic pathways and outlines synthetic strategies to enhance their therapeutic potential.To cite this article before page numbers are […]Hyun Su Kim
- Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity July 7, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00008D, HighlightYuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu, Yihua ChenDiscovery methods of microbial natural products (NPs) evolve with technological progress. This highlight article focuses on representative methods that achieve targeted mining by simultaneously predicting the structure and activity of NPs.To cite this […]Yuwei Zhang
- Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications June 26, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00027K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D. Keasling, Byung-Kwan ChoSynthetic protein interfaces enable programmable assembly of PKS […]Gahyeon Kim
- The ballet of nature: the interconvertible isomerisation of natural products June 22, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00019J, Review ArticleZe-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang LouThis review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers found in nature, including positional, tautomeric, geometric, optical, and conformational isomerism.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Ze-Jun Xu
- The chemical and biological properties of natural resorcylic acid lactones June 18, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00033E, Review ArticleYing Gao, Wanpeng Li, Hanli RuanThis review highlights the classification, structures, origins, biotargets, and clinical studies of naturally derived resorcylic acid lactones, a valuable polyketide template for drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Ying Gao
- Mass spectrometry-based metabolomics approaches to interrogate host–microbiome interactions in mammalian systems June 15, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00021A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Atharva S. Kulkarni, Guilherme M. P. Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall, Neha GargChemical crosstalk is universal to all life, niche-specific, and essential to thrive.To cite this article before […]Atharva S. Kulkarni
- Hot off the Press June 4, 2025Nat. Prod. Rep., 2025, 42,945-949DOI: 10.1039/D5NP90022K, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as shimianolide A from Chloranthus holostegius var. shimianensis.The content of this RSS Feed (c) The Royal Society of […]Robert A. Hill
- Illuminating the dark space of bioactive peptides with mass spectrometry March 11, 2025Nat. Prod. Rep., 2025, 42,950-955DOI: 10.1039/D4NP00057A, Viewpoint Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicole C. Parsley, Leslie M. HicksWith emerging resistance and a lag in the development of new molecules, bioactive natural product peptides are a source of new chemistries to drive advances in medicine and biotechnology.The […]Nicole C. Parsley
- ‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes February 27, 2025Nat. Prod. Rep., 2025, 42,1037-1054DOI: 10.1039/D4NP00053F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Robert A. Shepherd, Conrad A. Fihn, Alex J. Tabag, Shaun M. K. McKinnie, Laura M. SanchezIn this review we highlight recent advancements in mass spectrometry that have allowed for more efficient, robust, and […]Robert A. Shepherd
- The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives February 24, 2025Nat. Prod. Rep., 2025, 42,965-981DOI: 10.1039/D4NP00034J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wanessa Francesconi Stida Peixoto, Renato Crespo Pereira, Esthfanny dos Santos Souza Azevedo, Fernando Martins dos Santos, Ricardo Coutinho, Louisi Souza de OliveiraIn this article, we review the key processes contributing to the chemical […]Wanessa Francesconi Stida Peixoto
- Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics February 20, 2025Nat. Prod. Rep., 2025, 42,1020-1036DOI: 10.1039/D4NP00064A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Morgane Mauduit, Stéphane Greff, Marie Derrien, Charlotte SimmlerThis review highlights advances in characterizing exometabolites (EMs) from benthic organisms, starting with in situ sampling methods, then discussing how marine MS-based (exo)metabolomics benefits various fields […]Morgane Mauduit
- Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products January 20, 2025Nat. Prod. Rep., 2025, 42,956-964DOI: 10.1039/D4NP00026A, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brett C. Covington, Mohammad R. SeyedsayamdostNatural products have traditionally been discovered one molecule at a time. Here we describe new innovations in the acquisition and analysis of mass spectrometry data that now enable metabolomics-guided […]Brett C. Covington
- Effective data visualization strategies in untargeted metabolomics December 2, 2024Nat. Prod. Rep., 2025, 42,982-1019DOI: 10.1039/D4NP00039K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kevin Mildau, Henry Ehlers, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber, Justin J. […]Kevin Mildau
- Natural products targeting the metabolism of amino acids: from discovery to synthetic development July 10, 2025
