RSC – Nat. Prod. Rep. latest articles- Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products March 20, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00069B, Review ArticlePavel Yu. Ushakov, Alexey Yu. SukhorukovOver the past 25 years, the isoxazoline route to aldols has proven to be a powerful synthetic tool. This review discusses more than 50 syntheses of natural products, including macrolides, alkaloids, terpenoids, pseudosugars, and sulfolipids.To cite this article before page numbers are […]Pavel Yu. Ushakov
- Privileged natural product compound classes for anti-inflammatory drug development March 11, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00066H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Malcolm Z. Y. Choo, Julian A. T. Chua, Sean X. Y. Lee, Yuet Ang, W. S. Fred Wong, Christina L. L. ChaiThis review highlights six privileged classes of natural products – coumarins, […]Malcolm Z. Y. Choo
- Illuminating the dark space of bioactive peptides with mass spectrometry March 11, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00057A, Viewpoint Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicole C. Parsley, Leslie M. HicksWith emerging resistance and a lag in the development of new molecules, bioactive natural product peptides are a source of new chemistries to drive advances in medicine and […]Nicole C. Parsley
- Intramolecular cycloaddition of nitrones in total synthesis of natural products March 10, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00062E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Satoshi YokoshimaThis review highlights the intramolecular cycloaddition of nitrones as a valuable tool in the total synthesis of natural products, facilitating the construction of complex skeletons and the introduction of functional groups.To […]Satoshi Yokoshima
- Enzymatic crosslinking of histidine side chains in peptide natural products March 3, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00001G, HighlightYing Shi, Yinzheng Xia, Weijiang Gao, Jingxue Wang, Bing Shi, Huan WangHistidine-containing crosslinks are important structural motifs found in natural cyclic peptides of both ribosomal and non-ribosomal origin. Their formation involves intricate enzymatic chemistry.To cite this article before page numbers are assigned, use the DOI form of citation […]Ying Shi
- Microbial dynamics and Pseudomonas natural product production in milk and dairy products March 3, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00074A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ina Wasmuth, Christina Warinner, Pierre StallforthThis review focuses on the role of microorganisms and their natural products in milk and dairy products.To cite this article before page numbers are assigned, use the […]Ina Wasmuth
- ‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes February 27, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00053F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Robert A. Shepherd, Conrad A. Fihn, Alex J. Tabag, Shaun M. K. McKinnie, Laura M. SanchezIn this review we highlight recent advancements in mass spectrometry that have allowed for more efficient, robust, […]Robert A. Shepherd
- Antarctic bacterial natural products: from genomic insights to drug discovery February 25, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00045E, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.William Medeiros, Stanislava Kralova, Valéria Oliveira, Nadine Ziemert, Ludek SehnalThe article highlights the available data on Antarctic bacteria, their biosynthetic potential, and the successful NP discoveries while addressing the challenges in NP research […]William Medeiros
- The cytochalasans: potent fungal natural products with application from bench to bedside February 24, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00076E, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mohamed A. Tammam, Florbela Pereira, Elizabeth Skellam, Stefan Bidula, A. Ganesan, Amr El-DemerdashCytochalasans are fungal natural products with diverse structures and biomedical potential. This review explores their diversity, biosynthesis, pharmacokinetics, drug-likeness, and […]Mohamed A. Tammam
- The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives February 24, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00034J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wanessa Francesconi Stida Peixoto, Renato Crespo Pereira, Esthfanny dos Santos Souza Azevedo, Fernando Martins dos Santos, Ricardo Coutinho, Louisi Souza de OliveiraIn this article, we review the key processes contributing to the […]Wanessa Francesconi Stida Peixoto
- Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics February 20, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D4NP00064A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Morgane Mauduit, Stéphane Greff, Marie Derrien, Charlotte SimmlerThis review highlights advances in characterizing exometabolites (EMs) from benthic organisms, starting with in situ sampling methods, then discussing how marine MS-based (exo)metabolomics benefits various […]Morgane Mauduit
- Harnessing microbial co-culture to increase the production of known secondary metabolites February 19, 2025Nat. Prod. Rep., 2025, 42,623-637DOI: 10.1039/D4NP00052H, Review ArticleYu-Zhen Li, Wan-Qi Zhang, Peng-Fei Hu, Qiong-Qiong Yang, István Molnár, Peng Xu, Bo-Bo ZhangCo-culturing may provoke the biosynthesis of novel natural products. However, various microbial co-culture techniques may also boost the fermentation titer, yield and rate of known natural products – we review current progress towards such a […]Yu-Zhen Li
- Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery February 14, 2025Nat. Prod. Rep., 2025, 42,592-622DOI: 10.1039/D4NP00055B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Paris S. Salazar-Hamm, Frances E. Homan, Shyleigh A. Good, Jennifer J. M. Hathaway, Ashley E. Clements, Evelyn G. Haugh, Lindsay K. CaesarSubterranean microbial communities possess unique and untapped biosynthetic potential.The content of this […]Paris S. Salazar-Hamm
- Total synthesis of isoflavonoids February 11, 2025Nat. Prod. Rep., 2025, 42,540-591DOI: 10.1039/D4NP00060A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mamoalosi A. Selepe, Siyanda T. Mthembu, Molahlehi S. SonopoThe review is on synthesis of different classes of isoflavonoids that include isoflavones, isoflavanones, isoflavans, isoflavenes, pterocarpans, rotenoids, coumaronochromones, and coumestans.The content of this RSS […]Mamoalosi A. Selepe
- The role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis February 3, 2025Nat. Prod. Rep., 2025, 42,501-539DOI: 10.1039/D4NP00048J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yuya Kakumu, Ayesha Ahmed Chaudhri, Eric J. N. HelfrichThis review explores recent insights into the roles and enzymatic mechanisms of canonical and non-canonical tailoring enzymes in shaping and modifying terpene hydrocarbon scaffolds during […]Yuya Kakumu
- Advanced crystallography for structure determination of natural products February 3, 2025Nat. Prod. Rep., 2025, 42,429-442DOI: 10.1039/D4NP00071D, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jian-Guo Song, Wen-Cai Ye, Ying WangFour cutting-edge crystallography strategies for structure elucidation of natural products that are difficult to crystallize or in nanocrystalline form.The content of this RSS Feed (c) The Royal Society of […]Jian-Guo Song
- The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis January 27, 2025Nat. Prod. Rep., 2025, 42,482-500DOI: 10.1039/D4NP00059E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tobias M. Milzarek, Tobias A. M. GulderSorbicillinoids are a growing class of fungal natural products combining complex molecular architectures with pharmaceutically relevant bioactivities. This review covers their structural diversity, biosynthesis, and synthetic studies.The […]Tobias M. Milzarek
- Sesterterpenoids: sources, structural diversity, biological activity, and data management January 20, 2025Nat. Prod. Rep., 2025, 42,443-481DOI: 10.1039/D4NP00041B, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Valeria Iobbi, Valentina Parisi, Mauro Giacomini, Francesco De Riccardis, Paola Brun, Laura Núñez-Pons, Giuliana Drava, Paolo Giordani, Maria Chiara Monti, Roberto Poggi, Ylenia Murgia, Nunziatina De Tommasi, Angela BisioThe review is a full […]Valeria Iobbi
- Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products March 20, 2025
