RSC – Org. Biomol. Chem. latest articles- Tungsten-catalyzed continuous-flow oxidation of sulfides to sulfones with hydrogen peroxide March 2, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00125D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ken-ichi Fujita, Yasushi Okamoto, Kazuhiro Matsumoto, Jun-Chul Choi, Yoshihiro KonContinuous-flow oxidation of sulfides to sulfones was achieved with hydrogen peroxide (H2O2) using a column packed with a mixture of oxodiperoxotungstate–2,2’-bipyridine and activated carbon. […]Ken-ichi Fujita
- Multicomponent domino synthesis of 6-azabicyclo[3.2.1]octanes and their cascade ring expansion toward 2-azabicyclo[4.3.1]decanes March 2, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01817J, PaperNithya Natarajan, Dhanavardini Mouttousadeappane, Vasuki GnanasambandamComplex azabicyclic scaffolds were synthesized via base-promoted, diastereoselective MDRs using a novel isoindole-based methylene, featuring cascade ring expansion of 6-azabicyclo[3.2.1]octane to 2-azabicyclo[4.3.1]decane derivatives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Nithya Natarajan
- A pre-synthetic conjugation methodology of DNA and RNA: Combining on-column conjugation and tandem oligonucleotide synthesis February 27, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01870F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jagandeep Saraya, Derek Kyle O'FlahertyAmino modifiers are valuable chemical tools for nucleic acid bioconjugation applications and for probing potential mechanisms relevant to the origins of life. Herein, we describe a streamlined and cost-effective […]Jagandeep Saraya
- Functionalized porphyrin–fullerene dyads: a pathway to the enhanced performance of perovskite solar cells February 27, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00011H, PaperSafi Ullah, Shi-Qi Ye, Zheng-Chun Yin, Guan-Wu WangDyads consisting of a porphyrin with a bulky tert-butyl benzoate group linked to a fullerene cage through a biphenyl spacer were synthesized by the Prato reaction for application in perovskite layers.To cite this article before page numbers are assigned, use the […]Safi Ullah
- Mn(III)-mediated oxidative cyclisation via C(sp3)–H functionalisation: an efficient strategy for benzo-fused aza-heterocycle synthesis February 27, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00041J, CommunicationManpreet Singh, Joung-Wan Lee, Yebin Kim, Dae Young KimAn efficient Mn(III)-mediated strategy has been developed for C(sp3)–H functionalisation of N-aryl cyclic amines with malonates, enabling the synthesis of six- to nine-membered benzo-fused aza-heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Manpreet Singh
- Mechanisms of Molecular Oxygen-mediated Selective Hydroxyalkylation and Alkylation of Quinoxalin-2(1H)-ones with Alkylboronic acid: A DFT Investigation February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00112B, Paper Qianmei Hou, Da-Gang ZhouThe mechanisms for the molecular oxygen-mediated selective hydroxyalkylation and alkylation of quinoxalin-2(1H)-ones with alkylboronic acids have been investigated with the M06-2X-D3/ma-def2-SVP method and basis set. The SMD (solvation model based...The content of this RSS Feed (c) The Royal Society of ChemistryQianmei Hou
- Chromatographic purification of N–H ketimines via suppression of hydrolysis using dried silica gel and Et3N February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00153J, PaperShintaro ShibataChromatographic purification of N–H ketimines is often difficult because these compounds readily undergo hydrolysis on silica gel, regenerating the corresponding ketones during column chromatography. Combining silica gel pre-dried at 120...The content of this RSS Feed (c) The Royal Society of ChemistryShintaro Shibata
- Ynones as Versatile Electrophiles for the Divergent Synthesis of 4H-Chromenes and 1,4-Dihydroquinolines February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00097E, PaperBarla Thirupathi, Gitanjali Mishra, Potnuru Indu, Gitanjali MuduliAn efficient and transition-metal-free strategy for the synthesis of 4H-chromenes and 1,4-dihydroquinolines has been developed using 2-hydroxy/2-amino chalcones and ynones as key reaction partners. The transformation proceeds via a sequential...The content of this RSS Feed (c) The Royal Society of ChemistryBarla Thirupathi
- Substrate-Controlled Divergent Synthesis of Substituted Carbazoles through Cascade Reaction of 2-Alkenylndoles with α,β-Unsaturated Ketones February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00081A, CommunicationShizhou Yang, Mingliang Wang, Hong Jiang, Rui Wang, Yurou Xing, Shuang Luo, Qinlin DingSubstituted carbazoles are valuable N-heterocycles for synthesizing biologically relevant compounds. We established the phosphomolybdic acid/ion liquid-promoted divergent synthesis of substituted carbazoles, leveraging readily available 2-alkenylindoles and unsaturated ketones as starting...The content of this RSS Feed […]Shizhou Yang
- Biocatalytic synthesis of heterobiaryl sulfoxides: A comparative study between Baeyer-Villiger monooxygenases and unspecific peroxygenases February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00171H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pablo Vázquez-Domínguez, Julia Carrión-González, Desirée García-Requena, Marco Fraaije, Nikola Loncar, Rosario Fernández, Katrin Scheibner, Ana Gutierrez, Alejandro Gonzalez-Benjumea, Abel Ros, Gonzalo de GonzaloThe biocatalytic sulfoxidation of heterobiaryl indole-and pyrrole-based sulfides was investigated using […]Pablo Vázquez-Domínguez
- Positional isomerization of N-allyl compounds with a practical low-valent cobalt catalyst system February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00051G, CommunicationBranislav Kokić, Ljiljana Koračak, Marina Pećinar, Timothy R Newhouse, Bogdan Šolaja, Vladimir Ajdačić, Igor OpsenicaA practical, (E)-stereoselective synthesis of enamides and N-alkenyl heterocycles via cobalt-catalyzed positional isomerization is reported. The catalytic system consists of commercially available and bench-stable reagents. This method represents the first...The content of this RSS […]Branislav Kokić
- Adapting Bower's Intramolecular Aziridination Reaction Allows for a Metal-Free Synthesis of N-H Aziridines February 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00025H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Raju Silver, Steven Paul Kelley, Shyam SathyamoorthiInspired by Bower's intramolecular aziridination reaction, we have developed an intermolecular protocol for the preparation of N-H aziridines from olefins. Our reaction is operationally simple and involves […]Raju Silver
- Asymmetric hydrogenation of N-heterocycles for pharmaceutical intermediates: synthetic strategies and theoretical perspectives February 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00016A, Review ArticleYiting Pu, Tong Shao, Shaohua Yang, Haneol Cho, Chansoo Kim, Uk Sim, Shuihua Wang, Heechae ChoiThis review summarizes asymmetric hydrogenation strategies for N-heterocycles, integrating DFT-derived mechanistic insights to rationalize stereoselectivity and access key chiral scaffolds found in modern drugs.To cite this article before page numbers are assigned, […]Yiting Pu
- Base-promoted cascade haloamination/β-elimination of alkenyl thianthrenium salts: access to (Z)-β-chloroenamines February 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00027D, CommunicationQing-Long Lv, Yue Fan, Yuanbing Qi, Yuzhe Lu, Yinjiang Xue, Ao-Tong Shi, Hongqiang Xia, Dianjun LiA catalyst-free base-promoted cascade chloramination/β-elimination of alkenyl thianthrenium salts with N-chlorosulfonamides to generate (Z)-β-chloro-enamine products due to the π–π interaction has been developed with excellent stereoselectivity.To cite this article before page numbers are […]Qing-Long Lv
- Selective functionalization of the 1,6-anhydro moiety and of the double bond of levoglucosenone February 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00050A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marco Rizzo, Maria-Jose Calandri, Dmitrii Kurnosov, Chiara Lambruschini, Francesco Raboni, Renata Riva, Luca BanfiVersatile azide 1 was efficiently and selectively synthesized from bio-based LGO and used in various diversity-oriented transformations, affording Ugi products […]Marco Rizzo
- Advances in Electrochemical Hydroxylation Reactions: Mechanistic Understanding and Synthetic Opportunities February 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01951F, Review ArticleLucky Panwar, Shalini Verma, Manoj KumarElectrochemical hydroxylation reactions have provided new insights into reaction diversity and mechanistic pathways. These reactions, essential for functionalizing hydrocarbons, exhibit impressive selectivity and efficiency under mild conditions. Various catalytic systems,...The content of this RSS Feed (c) The Royal Society of ChemistryLucky Panwar
- Design of multivalent pharmacological chaperones against Pompe disease via metal-free ligation February 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00021E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marc Borie-Guichot, Abdelouahd Oukhrib, My Lan Tran, Cédric-Olivier Turrin, Yves Génisson, Laure Gibot, Stéphanie Ballereau, Cécile Dehoux-BaudoinWe report herein the design of multivalent pharmacological chaperones (PCs), based on d-and l-deoxynojirimycin (DNJ), to treat […]Marc Borie-Guichot
- Regioselective Iridium(III)-Catalyzed C-H Cyclization Using Acetylene Surrogate: Direct Access to Hydroxylated Polycyclic Phthalazinones February 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00063K, PaperHui Zhang, Lin Dong, Chao ZhangAn iridium(III)-catalyzed C-H cyclization between N-arylphthalazinones and 2-chloroacetaldehyde has been developed. This reaction provides efficient access to tetracyclic phthalazine derivatives with broad substrate scope. 2-Chloroacetaldehyde serves as an alkyne equivalent,...The content of this RSS Feed (c) The Royal Society of ChemistryHui Zhang
- Correction: Cascade synthesis of 2,3-disubstituted quinazolinones from methyl anthranilates, isocyanides and arylboronic acids via NHC–palladium-catalyzed oxidative coupling reactions February 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB90024K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chun Qian, Hao Xu, YuQin ZhangTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryChun Qian
- Ring-opening S-alkylation of sulfonium salts with sulfenamides February 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00037A, CommunicationZeyuan Zhao, Jun Guo, Xiang Wang, Youcan Zhang, Tiefeng Xu, Ya LiHere, we reported a novel and efficient method for the synthesis of S-alkyl substituted sulfilimines by employing a base-promoted ring-opening reaction of sulfonium salts with sulfenamides. This reaction proceeds smoothly...The content of this RSS Feed (c) The […]Zeyuan Zhao
- Tungsten-catalyzed continuous-flow oxidation of sulfides to sulfones with hydrogen peroxide March 2, 2026
