RSC – Org. Biomol. Chem. latest articles- Rhodium(II)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions December 12, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01742D, CommunicationHaiqing Wang, Hekun Huang, Xinke Zhang, Chunan Wang, Zhuodi Chen, Chengyong Su, Xiang Fu, Wenhao HuA recyclable Rh-MOF enables efficient, diastereoselective carbene reactions with high turnover and continuous-flow gram-scale synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Haiqing Wang
- DPPA-mediated One-Pot Cascade Transformation Enables Direct Synthesis of Fluorogenic 2-Aminomaleimides and Thioaminomaleimides December 11, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01619C, CommunicationHarendra Kumar, Aakriti Garg, Sawan Kumar, Devendra Dhaked, Sreya Gupta, Subhendu BhowmikA one-pot cascade metal-free and solvent-free strategy for the synthesis of 2-aminomaleimide, thioaminomaleimide, and 2-amidomaleimide directly from maleic anhydride is reported. DFT calculation supports the proposed cascade pathway for the...The content of this RSS Feed (c) The […]Harendra Kumar
- TfOH-Catalyzed Cyclization/Rearrangement of Alkynyl Aryl Sulfoxides for Metal-Free Synthesis of Six- to Nine-Membered Sulfur-Containing Heterocycles December 11, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01829C, PaperYuto Iwanami, Akira Tsubouchi, Keiichi Noguchi, Akio SaitoWe herein report the TfOH-catalyzed cyclization/rearrangement of alkynyl aryl sulfoxides via intramolecular oxygen transfer of sulfoxides to alkynes as a metal-free synthetic approach for medium-sized sulfur-containing heterocyclic compounds, which are...The content of this RSS Feed (c) The Royal Society of ChemistryYuto Iwanami
- Correction: Visible light photocatalytic reductive hydroalkylation and deuterium alkylation to access α-silylated bicyclo[1.1.1]pentanes December 11, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB90161H, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Changlong Zheng, Xin Liu, Bin Hu, Ting Lin, Shipeng Luo, Chenguang LiuTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Changlong Zheng
- The Ugi reaction in the synthesis of pyrrolo[3,4-c]pyridine derivatives December 11, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01705J, PaperSergey V. Fedoseev, Sergey A. Blinov, Anna D. Maksimova, Mikhail Yu. BelikovFor the first time, bifunctional pyridine derivatives containing carbonyl and carboxyl groups were introduced into the Ugi reaction. The developed methodology is characterized by mild conditions, the absence of a catalyst and substrate versatility.To cite this article […]Sergey V. Fedoseev
- Direct C–H functionalization on heteroaromatic rings December 10, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01613D, Review ArticleNai-Xing Wang, Shi Tang, Yu-Qiang Zhou, Dumitra Lucan, Evan Wu, Yalan XingThis review focuses on recent advances in coupling reactions on various heteroaromatic rings via C–H bond functionalization, and provides a detailed, in-depth investigation into the mechanisms of most reactions of C–H functionalization on heteroaromatic rings.To cite […]Nai-Xing Wang
- Recent advances in the photocatalytic synthesis of isoquinoline-1,3-dione derivatives December 10, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01730K, Review ArticleWei Lian, Bei Liu, Qiyang Liu, Jin-Wei YuanIsoquinoline-1,3(2H,4H)-diones constitute an important class of nitrogen-containing heterocycles that are broadly distributed in natural products and bioactive pharmaceutical compounds, exhibiting diverse biological activities. In recent years, visible-light photocatalysis has emerged...The content of this RSS Feed (c) The Royal Society of […]Wei Lian
- Synthesis of enantiomerically enriched β-N-amino substituted analogs of the (S)-α-alanine via sequential nucleophilic Michael addition, cross-coupling and [3+2]-cycloaddition reactions on the coordination sphere of a chiral Ni(II) complex of amino acid Schiff bases December 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01593F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Emma A Khachatryan, Lala A Stepanyan, Hasmik Gevorgyan, Armen Sargsyan, Anahit Hovhannisyan, Anna Mkrtchyan, Andrei Malkov, Ashot S. SaghyanA concise synthetic route to enantiomerically enriched β-N-substituted (S)-α-diaminopropanoic acids is reported. An acetylene group […]Emma A Khachatryan
- N-Heterocyclic Carbene Ruthenium Complexes Synthesized by Hydrogen-Bonding-Assisted Strategy for Dehydrogenative Rearrangement of Esters December 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01811K, PaperZhi-Yuan Gong, Sheng Tao, Xiao-Bin Li, Tao Wang, Fei Chen, Zhi-Hong Du, Chun-Bo Bo, Min Li, Ning LiuSimplifying the synthetic procedure of transition-metal complexes is of great significance for homogeneous catalysis. Herein, a new, efficient, and practical method has been developed for synthesizing N-heterocyclic carbenes (NHC)-ruthenium complexes...The content […]Zhi-Yuan Gong
- Solvent-free reactions at work towards densely functionalized targets: synthesis of 3-amino(azido)-3-deoxy-D-galactose, a key structural motif of relevant galectin ligands December 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01710F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alfonso Iadonisi, Serena Traboni, Emiliano Bedini, Fabiana Esposito, Marcello ZiacoA straightforward approach is reported for the synthesis of 3-deoxy-3-amino(azido)-D-galactose, key intermediates for the synthesis of high affinity inhibitors of galectins with an established […]Alfonso Iadonisi
- A Facile Synthesis of [1,2,3]Triazolo[1,5-a]quinazolines via Copper-Catalyzed Tandem Reaction and Its Denitrogenative Transformation to 2-Acyl-quinazolines December 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01737H, CommunicationXinxiang Liu, Huijuan Wang, Yalan Liu, Can Wang, Chao-Yang Liu, Yunfeng ChenAn one-pot reaction protocol of 2-bromobenzyl azides with substituted acetonitriles for high effective synthesis of [1,2,3]triazolo[1,5-a]quinazolines was developed. The reaction process involved base-promoted [3+2] cyclization, Cucatalyzed Ullmann coupling, oxidative aromatization,...The content of this RSS Feed (c) The […]Xinxiang Liu
- One-step synthesis of chiral multifluorine-substituted-alkoxy boranils using H3BO3 as boron source December 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01781E, CommunicationShumi Han, Yingchao Dou, Jun-Long NiuWe report a one-step synthesis of chiral multifluorine-substituted-alkoxy boranils using H₃BO₃ as boron source. With salicyloxazolines or in-situ generated N,O-Schiff bases as ligands, a series of chiral mono or bis-boron...The content of this RSS Feed (c) The Royal Society of ChemistryShumi Han
- Reductive Deoxygenation of Tertiary Alcohols: Cobalt-Catalyzed Hydrosilylation Approach December 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01788B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Swetarani Meher, Ratiraman Swain, Braja Kishore Marndi, Bidraha BaghDehydrogenation of tertiary alcohols presents both significant challenges and notable importance in synthetic chemistry. We report readily available Co₂(CO)₈ catalyzed hydrosilylation protocol for the reductive […]Swetarani Meher
- Cationic halogenated BODIPYs as water-soluble photosensitizers for photodynamic therapy December 5, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01499A, PaperArrhon Mae Bongo, Yeji Kim, Duy Khuong Mai, Jung Suk Kim, Sung Cho, Ho-Joong KimA halogenated cationic dye platform generates reactive oxygen efficiently and accumulates in cancer cells, enabling strong light-triggered cytotoxicity with clear intracellular fluorescence.To cite this article before page numbers are assigned, use the DOI form […]Arrhon Mae Bongo
- Synthesis of S- or N-glycomimetics of D-galactono-1,4-lactone: inhibitors of a β-galactofuranosidase December 4, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01674F, PaperWalter E. Jara, Carla Marino, Linda Toro Melgarejo, Oscar Varela, Evangelina RepettoThe synthesis of 4-thio-D-galactonic acid 1,4-thiolactone (5), 4-deoxy-D-galactono-1,4-lactam (14), and N-substituted lactam derivatives (20a–f) is described. These glycomimetics are inhibitors of P. fellutanum β-galactofuranosidase.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Walter E. Jara
- X-shaped π-conjugated fluorophores enable cooperative ion-pair recognition with multicolour emission December 4, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01696G, PaperRyota Tazawa, Kaho Watanabe, Kei Mizuguchi, Shoki Mizoguchi, Takayuki Chiba, Shuji Okada, Ryohei YamakadoAn X-shaped π-conjugated molecule with orthogonal cation and anion binding sites shows positive hetero-ion cooperativity, enabling tunable multicolour photoluminescence in response to ion-pair binding.To cite this article before page numbers are assigned, use the DOI […]Ryota Tazawa
- Photodriven, TFA-promoted oxidative dehydrogenative coupling of quinoxalin-2(1H)-ones with 5-pyrazolones December 4, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01748C, CommunicationPeipei Ma, Junyu Wang, Hongli Wu, Haifeng Gan, Fei Cao, Jianliang ZhuA protocol of photodriven, TFA-mediated oxidative coupling of quinoxalinones with 5-pyrazolones has been realized under air, and mechanistic research confirmed that radical and ionic pathways exist. A visible-light-catalyzed method was first used.To cite this article before page […]Peipei Ma
- Sulfonated, sulfated thioglycosides and multivalence in heparanase inhibition December 4, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01623A, PaperDindet Steve-Evanes Koffi Teki, Bamoro Coulibaly, Jamal El-Abid, Abed Bil, Aurélie Vallin, José Kovensky, Vincent ChagnaultNovel sulfated and sulfonated thiodisaccharides, and their multivalent derivatives, as efficient heparanase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Dindet Steve-Evanes Koffi Teki
- Preparation of pseudocyclic I(III) reagents and their application in selective oxidations December 4, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01641J, CommunicationXiangyu Zhan, Yong You, Cong Li, Dan Xiao, Lingzhi Xu, Shuoshuo Zhang, Yunfei DuFour N,N-disubstituted pseudocyclic I(III) reagents were efficiently synthesized from ortho-iodobenzamides using mCPBA. These hypervalent iodine oxidants enable selective oxidation of sulfides to sulfoxides and other oxidative transformations.To cite this article before page numbers are assigned, […]Xiangyu Zhan
- Oxabispidine-derived ionizable lipids for effective mRNA delivery to lungs using lipid nanoparticles December 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01888A, PaperCharles Chen, Eric L Dane, Steven Oag, Elin Sand, Patrik Andersson, Annette Bak, Liping ZhouLipid nanoparticles have been proven effective for mRNA delivery to liver and in a vaccine context. There is general interest in identifying new ionizable lipids to enable safe and efficient...The content of this RSS […]Charles Chen
- Rhodium(II)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions December 12, 2025
