RSC – Org. Biomol. Chem. latest articles- Efficient synthesis of trifluoromethyl-containing vicinal chlorohydrins and dichlorides via Mn-catalyzed chlorohydroxylation and dichlorination of α-(trifluoromethyl)styrenes August 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01253H, CommunicationJiaqi Huang, Ronghua Zhuge, yuhao Qian, Qingchun Huang, Song CaoEfficient method for the synthesis of trifluoromethyl-containing vicinal chlorohydrins and dichlorides via Mn-catalyzed chlorohydroxylation and dichlorination of α-(trifluoromethyl)styrenes using Na2S2O8 as an oxidant and NaCl as a chlorine source was...The content of this RSS Feed (c) The Royal Society […]Jiaqi Huang
- Organocatalytic modular synthesis of 2-functionalized 2,5-dihydrofuran from γ-hydroxy enal August 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01216C, CommunicationTie Lei, Jun Tan, Yifei Zhang, Dengke MaA convenient and modular method for the preparation of diverse 2-O/N/C-functionalized 2,5-dihydrofurans has been developed starting from readily available γ-hydroxy enals via organocatalysis. This reaction features a broad substrate scope,...The content of this RSS Feed (c) The Royal Society of ChemistryTie Lei
- Switchable synthesis of sulfinylated and sulfonylated indoles and benzofurans from o-aminophenyl/o-hydroxyphenyl propargyl alcohols and β-sulfinyl esters August 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00969C, CommunicationMing Bian, Cheng-Mei Luo, Li-Na Gao, Tian-Yu Zhang, Yu-Ning Gao, Cun-Feng Song, Hui-Yu Chen, Zhen-Jiang LiuThe cascade reaction of o-aminophenyl/o-hydroxyphenyl propargyl alcohols with β-sulfinyl esters was explored under basic conditions. o-Aminophenyl propargyl alcohols were converted to 3-sulfinyl indoles using KOH, while 3-sulfonyl indoles were obtained...The content of this […]Ming Bian
- A high lipid-soluble probe for ONOO− recognition in the endoplasmic reticulum and imaging of cerebral ischemia-reperfusion injury August 21, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01119A, PaperYu-An Feng, Zi-Hao Liu, Wei Du, Ya-Wen Wang, Yu PengA new peroxynitrite (ONOO−) recognition fluorescent probe (SWJT-27) was designed and synthesized for endoplasmic reticulum (ER) stress imaging during the cerebral ischemia-reperfusion injury (CIRI) process.To cite this article before page numbers are assigned, use the DOI form of citation […]Yu-An Feng
- Interaction Studies by NMR on the Multivalent Interaction between Chondroitin Sulfate E Derivatives and Langerin Receptor August 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00845J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria J. García-Jimenez, Sergio Gil, Pedro Dominguez, Laura Roldan, Michel Thepaut, Francisco M. Arrabal, Ignacio Fernández, Franck Fieschi, Javier Rojo, José L. de Paz, Pedro M NietoIn this paper, we presented the 3D […]Maria J. García-Jimenez
- Construction of dansylated (fluorescent) amino acid motifs via C(sp3)-H arylation August 21, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01017A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Debabrata Bhattacharya, Yashika Aggarwal, Subhankar Bodak, Sampurna Pal, Indranil Banerjee, Srinivasarao Arulananda BabuWe described the construction of a library of new examples of dansylated (fluorescent) phenylalanine-type unnatural amino acid scaffolds using the Pd(II)-catalyzed […]Debabrata Bhattacharya
- Oxidative Functionalization of Cyclopentane-1,3 Diones: Cell Imaging Studies of Diphenothiazine Derivatives. August 20, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01082A, CommunicationSapana Dubey, Pragya Trivedi, Madan Sau, Sukanya Mandal, Shreya Roy, Subhrakanta Rout, Subhojit Das, Gokarneswar Sahoo, Damien Bonne, Tapas DasThis article presents a metal free expedient approach for simultaneous incorporation of heteroatoms and unsaturation in the cyclopentane-1,3-dione via aerial oxidation. We have introduced three distinct methodologies viz. secondary […]Sapana Dubey
- Stereoselective Convergent Total Synthesis of Tonkinelins August 20, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01214G, PaperRodney Agustinho Fernandes, Anupama KumariWe report the stereoselective synthesis of (17S,18S,36S)-tonkinelin and its diastereomer (17R,18R,36S)-tonkinelin via a convergent strategy involving the stepwise construction of two key fragments - a chiral ester-derived phosphonium salt and...The content of this RSS Feed (c) The Royal Society of ChemistryRodney Agustinho Fernandes
- Multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing imidazole moiety August 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01230A, PaperEkaterina Sergeevna Uvarova , Anton Viktorovich Kutasevich, Tatiana Yu. Koldaeva, Vitaly MityanovA methodology for the synthesis of 2-aminofurans containing an imidazole substituent has been developed. The method is based on a three-component condensation of 2-unsubstituted imidazole N-oxides, arylglyoxals, and 3-ketonitriles. The...The content of this RSS Feed (c) The […]Ekaterina Sergeevna Uvarova
- Visible-light-promoted tandem radical fluoroalkylation/cyclization to access fluoroalkyl-containing chromones/chroman-4-ones August 19, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01148E, PaperYuanyuan Ren, Yuxiu Zhou, Xiaona Pan, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yulai HuVarious fluoroalkyl chromones/chroman-4-ones are synthesized through radical cascade fluoroalkylation/cyclization reactions of o-hydroxyaryl enaminones or 2-(allyloxy)benzaldehydes with fluoroalkyl reagents CF3Br and 1,2-dibromotetrafluoroethane.To cite this article before page numbers are assigned, use the DOI form of citation […]Yuanyuan Ren
- Asymmetric total synthesis of (+)-fusariumin and (+)-sporotricale methyl ether: Exploration of Cu(I) catalysed regiodivergent cascade cyclization strategy August 19, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01245G, PaperSamik Nanda, Swagata Das, Anupa KarmakarAsymmetric total synthesis of isocoumarin-based natural product (+)-fusariumin was achieved for the first time through Cu(I) catalysed 6-endo-dig cyclization as a key step. Synthesis of phthalide-based natural product sporotricale methyl...The content of this RSS Feed (c) The Royal Society of ChemistrySamik Nanda
- New synthesis of β-(4-semicarbazido)carboxylic acid-based peptidomimetics and 3-amino-5,6-dihydrouracils via amidoalkylation protocol August 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01075F, PaperAnastasia Fesenko, Pavel Banschikov, Anatoly ShutalevA new approach to peptidomimetics consisting of α-aza-amino acid and β-amino acid residues, namely β-(4-semicarbazono)- and β-(4-semicarbazido)carboxylic acids, their esters and hydrazides has been developed. The synthesis involve the amidoalkylation...The content of this RSS Feed (c) The Royal Society of ChemistryAnastasia Fesenko
- Ruthenium-catalyzed synthesis of tricyclic 1,5-fused 1,2,3-triazole piperazines August 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01137J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Said Stålsmeden, Flavia Ferrara, Andreas Ekebergh, Maureen Gumbo, August Runemark, Johan R. Johansson, Per-Ola Norrby, Nina KannFused tricyclic triazole piperazines were prepared in an atom economic manner via two consecutive ruthenium-catalyzed transformations.To […]Anna Said Stålsmeden
- Highly regio- and diastereoselective construction of spirocyclic compounds via palladium-catalyzed [3 + 2] cycloaddition of vinyl methylene cyclic carbonates with pyrrolidinones August 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01194A, CommunicationHuizhi Liu, Jiayi Zong, Boxuan Zhang, JiaHao Wang, Guohui Zheng, Miaolin Ke, Fener ChenA palladium-catalyzed [3 + 2] cycloaddition of vinyl methylene cyclic carbonates with pyrrolidinones, which enables the efficient synthesis of various [5,5]-spirolactam derivatives with up to 98% yield and up to >20 : 1 dr, was developed.To cite […]Huizhi Liu
- Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions August 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01048A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Selin Yilmaz, Haimei Zhou, Çağrı Özsan, Angelo Frei, Peter O'Brien, William Paul UnsworthA versatile approach for the synthesis of a diverse library of macrocyclic and medium-sized ring lactams is described. Up to three-sequential […]Selin Yilmaz
- Synthesis of Unsymmetrical Bisperoxides via Semicarbazone Ozonolysis in Presence of Hydroperoxides August 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01159K, PaperRoman A Budekhin, Darya Y Sliguzova, Dmitri I Fomenkov, S. V. Baranin, Alexander Olegovich Terent'evA selective method has been developed for the synthesis of unsymmetrical geminal bisperoxides via the ozonolysis of semicarbazones in a hydroperoxide containing medium. The replacement of the C=N moiety by...The content of this RSS […]Roman A Budekhin
- O-Aryl carbamates of 2-substituted piperidines: anionic Fries rearrangement and kinetic resolution by lithiation August 18, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01049G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Marra, Fabrizio Morelli, Federica De Nardi, Emanuele Priola, Iain Coldham, Marco BlangettiA chemodivergent organolithium-mediated protocol to promote anionic Fries rearrangement (AoF) or kinetic resolution (KR) processes starting from O-aryl carbamates of 2-substituted […]Francesco Marra
- Synthesis and physicochemical evaluation of phosphorus(III) and phosphorus(V) substituted benzoxaboroles August 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01146A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elisa Ospanow, Mirele Barsoum, David L JakemanThis study presents a one-pot synthesis of phosphorus(III) benzoxaboroles using hypophosphorous acid to yield H-phosphinates. These H-phosphinates, together with their phosphonate congeners, were systematically evaluated for their […]Elisa Ospanow
- Rapid Construction of Furan-linked Bisheterocycles via Palladium-catalyzed Domino Heck/Cross-coupling Reaction August 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01081K, PaperDu Wang, Zhilong Yin, Xueli Feng, Huixuan Zhu, Fan Gao, Jiaxin Li, Jingli Zhang, Ye YuanA palladium-catalyzed domino Heck/cross-coupling reaction of alkene-tethered aryl iodides with β-chloroenones is reported. This reaction enables the formation of one C-O bond, two C-C bonds to construct bisheterocycles in a...The content of this […]Du Wang
- Silver-Mediated Intermolecular Regioselective C-H Trifluoromethoxylation of Arenes August 18, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01162K, CommunicationLu Guo, Ruijian Fang, Yun Liu, Zhenbo Zhao, Nuochen Ye, Zhijie Deng, Muhammad B Altaf, Pingping TangThe direct introduction of a trifluoromethoxy group into aromatic C-H bonds is a highly desirable yet formidable transformation, primarily due to the challenges in controlling regioselectivity. While the intramolecular version...The content of […]Lu Guo
- Efficient synthesis of trifluoromethyl-containing vicinal chlorohydrins and dichlorides via Mn-catalyzed chlorohydroxylation and dichlorination of α-(trifluoromethyl)styrenes August 24, 2025
