RSC – Org. Biomol. Chem. latest articles- Pyridine-boryl radicals-mediated reductive homocoupling of para-quinone methides March 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00078A, PaperYan-Bo Wang, Yan-Zhao Cui, He Li, Huiyi Liu, Hao-Qi Yuan, Hao-Tian Zhou, Xiao-Sai WangAn effective and straightforward pyridine-boryl radicals-mediated reductive homocoupling of para-quinone methides was developed, affording a broad range of differently substituted tetraarylethane derivatives in good to nearly quantitative yields. This metal-free...The content of this RSS Feed […]Yan-Bo Wang
- Progress in Intermolecular Radical Umpolung Addition to Alkenes March 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00278A, Review ArticleYeming Wang , Chaoqun Zhang, Jian-Quan LiuConventional organic synthesis is constrained by innate polarity, often requiring multi-step sequences under harsh conditions. The umpolung strategy enables polarity reversal for unconventional bond formations, while radical chemistry efficiently forges...The content of this RSS Feed (c) The Royal Society of ChemistryYeming Wang
- Palladium-catalyzed enantioselective decarboxylative [3+2] cycloaddition of 5‑vinyloxazolidine-2,4-diones with sterically encumbered ketoimines toward chiral polycyclic 1,4-imidazolidinones March 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00235H, CommunicationJuan Liao, Wei Sun, Guo-Yin Sun, Xue-Song Peng, Lei Yang, Yong You, Zhen-Hua Wang, Jian-Qiang Zhao, Ming-Qiang Zhou, Wei-Cheng YuanA palladium-catalyzed decarboxylation of 5‑vinyloxazolidine-2,4-diones for in situ generation of aza-π-allylpalladium zwitterionic intermediates, which act as 1,3-N,C-dipoles in enantioselective [3+2] cycloaddition with sterically encumbered cyclic N-sulfonyl ketoimines was first […]Juan Liao
- Facile Synthesis of Redox-Responsive Peptide Coacervates for Cytosolic Protein Delivery March 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00358C, PaperXiaona Han, Ruihui Han, Jiaxin Yang, Xiao Hua, Yi-Ming LiHistidine-rich peptide (HBpep) coacervates are promising intracellular delivery vehicles due to their excellent cellular uptake. However, cargo release usually relies on redox-responsive motifs linked to lysine side chains via multi-step...The content of this RSS Feed (c) The Royal Society […]Xiaona Han
- Development of a convenient and useful transesterification reaction using a catalytic amount of strontium alkoxide March 20, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00072J, CommunicationChisato Kamada, Ryosuke Shimoda, Masaharu Ueno, Norikazu MiyoshiStrontium tert-butoxide can be easily synthesized resulting in a white solid with long shelf life. Using the strontium tert-butoxide as a catalyst, transesterification of various methyl esters with various alcohols...The content of this RSS Feed (c) The Royal Society of ChemistryChisato Kamada
- Viscosity-Responsive Styryl Benzoxazole Probes for Lipid Droplet Visualization March 19, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00086J, PaperVijay Sai Krishna Cheerala, Simran Gaith, Prateek Sarkar, Deeksha Rajput, Sriram KanvahWe report a rapid, solvent-minimized solid-state synthesis of a series of styryl benzoxazole fluorophores achieved within 40-180 seconds under ambient conditions, eliminating the need for chromatographic purification. The synthesized dyes...The content of this RSS Feed (c) The […]Vijay Sai Krishna Cheerala
- Design and Synthesis of Aculeatin Oxo-Analogues and Aculeatin Natural Products Enabled by Oxo-Carbenium Ion Cyclization March 19, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00165C, PaperManoj Kumar, Shubham Singh, Parthasarathi SubramanianAculeatin natural products have garnered significant attention for their exceptional biological activities, such as antimalarial, antiprotozoal, and cytotoxic properties, prompting extensive total synthesis studies and the development of unnatural analogs....The content of this RSS Feed (c) The Royal Society of ChemistryManoj Kumar
- Organocatalytic Enantioselective aza-Henry reaction of Pyrazolone Ketimines March 19, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00412A, PaperYakun Wang, Xiaoyu Du, Han Wang, Xu Kong, Jinghao Tian, Yuli Zhang, Jinying Liang, Pengfei Yang, Tao ZhangAn efficient and enantioselective aza-Henry reaction of pyrazolone ketimines with nitroalkanes has been realized by employing low loading of 1 mol% of a cinchona alkaloid-derived bifunctional squaramide as an organocatalyst....The content […]Yakun Wang
- HTE-enabled Discovery of Palladium-Catalysed (Hetero)Arylation of Barbituric and Meldrum's Acid March 19, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00287K, CommunicationKacper Jan J Patej, Joel Bigolin, Vera Jost, Monique Ucar, Marius D. R. Lutz, Georg WuitschikThis study demonstrates the potential of high-throughput experimentation (HTE) to discover favorable conditions for the direct palladium-catalysed arylation of unprotected barbituric acid and Meldrum's acid-conditions that are not easily attainable...The content of this […]Kacper Jan J Patej
- Chemoselective transfer hydrogenation of alkynoates enabled by Cu(I)-photosensitizer catalysis March 18, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00115G, PaperKun Zhang, Ziwen Huang, Yin Xu, Yunkui LiuHydrogenation reactions are of great value in synthetic chemistry, however, it has been challenging to distinguish the reactivity of various reactive motifs. Herein, we report a novel strategy for the...The content of this RSS Feed (c) The Royal Society of ChemistryKun Zhang
- Cyclisations and Hydrolysis of Geranyl and Farnesyl Halides in water Facilitated by Ultrasound-Induced Emulsification March 18, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01695A, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jan Luca Budde, Andreas Kirschning, Gerald DrägerHow stable are geranyl and farnesyl halides in water? Given the current increased interest in mimicking terpene synthases, we address this fundamental question by investigating their behaviour […]Jan Luca Budde
- A Catalyst-Free Facile Synthesis of 2-(dihydropyridyl)benzothiazoles from (Benzothiazol-2-yl)acrylonitriles: A Green Route March 18, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00288A, CommunicationNikunj Singh, Rajnish Budhwan, Megha Rawat, Rama Krishna PeddintiAn efficient, metal-free and catalyst-free, atom-economical green route for the synthesis of C-2-(dihydropyridyl)benzothiazoles is described. The synthesis is achieved by [3+3] cycloaddition reaction of (benzo[d]thiazol-2yl)acrylonitriles with cyclic 1,1-enediamines under mild...The content of this RSS Feed (c) The Royal Society of […]Nikunj Singh
- Visible-Light-Induced Regioselective N-oxazolidinone radical addition to indoles and arenes via EDA complex formation March 18, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00369A, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.MONICA FIORENZA BOSELLI, Sara Ferrario, Niccolò Intini, Kirsten Zeitler, Alessandra PuglisiWe report the generation of N-oxazolidinone radicals via electron donor-acceptor (EDA) complex formation. Visible light irradiation of pyridinium-based radical precursors, either in the […]MONICA FIORENZA BOSELLI
- Catalyst- and Additive-Free Reduction of Carboxylic Acids and Amides Using Ammonia Borane as Hydrogen Source March 18, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00293E, CommunicationWanzhen Guo, Xing Lu, Hui Zhou, Nana Wei, Xin Liu, Zhiqiang Ren, Bo HanThe study reports an economical synthetic protocol employing air-stable NH3·BH3 as an H2 equivalent for the catalyst- and additive-free reduction of both aliphatic and aromatic carboxylic acids, offering a series...The content of this RSS Feed […]Wanzhen Guo
- Biocatalytic synthesis of a novel atorvastatin catechol derivative as an anti-hyperlipidemic drug candidate using bacterial tyrosinase March 18, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00212A, CommunicationHae Chan Jeong, Yu-Jin Lee, Gun Su Cha, Fikri A. R. Hardiyanti Oktavia, Chan Mi Park, Chul-Ho YunAtorvastatin is converted to 3,4-dihydroxy atorvastatin via sequential P450-tyrosinase biotransformation. The novel atorvastatin derivative retains potent HMG-CoA reductase inhibitory activity comparable to the parent drug.To cite this article before page numbers […]Hae Chan Jeong
- Copper-catalyzed radical 1,2-oxysulfoximination of β,γunsaturated oximes for the synthesis of sulfoximine-substituted isoxazolines March 18, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00244G, CommunicationMuthukrishnan Murugan, Kishor R Thete, Vijay Vara, Raj Y PatelHerein, we report a copper-catalyzed radical 1,2oxysulfoximination of β,γ-unsaturated oximes. The transformation proceeds via intramolecular iminoxyl radical cyclization followed by interception with sulfoximines, enabling efficient access to sulfoximine-substituted isoxazolines in...The content of this RSS Feed (c) The Royal Society […]Muthukrishnan Murugan
- Recent Advances in the Deuteration of Indoles March 17, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00215C, Review ArticleXianwen Zeng, Liping Chen, zhang jinquanDeuteration has evolved into a transformative strategy in medicinal chemistry, materials science, and mechanistic research, owing to its ability to modulate molecular properties without perturbing core structures. As a privileged...The content of this RSS Feed (c) The Royal Society of ChemistryXianwen Zeng
- Cobalt-Catalyzed Synergistic Oxidation of Benzylic C–H Bonds Using Ozone and Hydrogen Peroxide March 17, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00130K, PaperShiyun Li, Wenzhi Cui, Lulu Wang, Jun Huang, Bin Wen, Xingquan Chen, Haibo Zhu, Xiaojun BaoOxidative transformation of benzylic C(sp³)–H bonds into carbonyl functionalities under mild conditions offers an efficient and versatile strategy for synthesizing high-value aromatic carboxylic acids and ketones. Herein, we report a...The content of this […]Shiyun Li
- Application of the intramolecular Diels-Alder vinylarene (IMDAV) reaction for the synthesis of benzo-and carbocyclofuroisoindolecarboxylic acids and its limitations March 17, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01918D, PaperElizaveta D Yakovleva, Evgeniya Shelukho, Pavel Erokhin, Valentina Ilyushenkova, Aleksandra S Guryeva, Nikita Logvinenko, Victor N Khrustalev, Mikhail S. Grigoriev, Fedor Ivanovich Zubkov, Vladimir P. ZaytsevFurylallylamines, readily accessible from the corresponding furylacroleines, react with maleic, citraconic and trifluoromethylmaleic anhydrides to form acids with a furo[2,3-f]isoindole core.The reaction sequence […]Elizaveta D Yakovleva
- Pyromellitic dihydrazides as hydrolytically stable analogs of pyromellitic diimide March 17, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00281A, CommunicationJourney M. Amundson, Ryan B. Brush, Kara M. Jensen, Baela R. Funk, Healeam Jung, Sam K. Mamicha, Victor G. Young, Eryck Garcia L., Liana M. Klivansky, Dennis D. CaoPyromellitic dihydrazide is a significant upgrade to pyromellitic diimides, combining ease-of-synthesis, extreme alkaline stability, and thermal and structural features together […]Journey M. Amundson
- Pyridine-boryl radicals-mediated reductive homocoupling of para-quinone methides March 20, 2026
