RSC – Org. Biomol. Chem. latest articles- Digold photosensitizer for visible light [2+2] cycloaddition and E/Z isomerization reactions October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01503K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tommaso Ruggiero, James Fortwengler, Kristof Van Hecke, Mark Thompson, Thomas Heugebaert, Steven P NolanEnergy transfer photocatalysis has emerged as a powerful platform for a wide variety of transformations, yet advances in this area […]Tommaso Ruggiero
- Synthesis of hexahydroisobenzofuran-1(3H)-ones via pyridine-boryl radical-catalyzed intramolecular cascade cyclization of alkene-tethered cyclobutyl ketones October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01566A, CommunicationXiao-Ye Yang, Hua Huang, Qiong Wu, Yun-Xuan Tan, Ping TianCyclobutane is a valuable C4 synthon, and the cycloaddition reactions involving donor-acceptor cyclobutanes have been extensively studied. However, the ring-opening cyclization reactions of acceptor-acceptor cyclobutanes remain largely unexplored due to...The content of this RSS Feed (c) The Royal Society […]Xiao-Ye Yang
- Trichosterol A, a unique 6/6/6/5/6-fused steroid-alkaloid hybrid with bioherbicidal activity from Trichoderma koningiopsis October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01352F, CommunicationShuyuan Mo, Jian Yang, Jie Zhao, Jianping Wang, Yonghui Zhang, Zhengxi HuNaturally occurring steroids constitute a class of pharmacologically privileged scaffolds, owing to their rigid tetracyclic frameworks and well-defined stereochemistry, which have served as the basis for numerous clinically important drugs....The content of this RSS Feed (c) The […]Shuyuan Mo
- Synthesis of Tetrahydropyrrolo[1,2-a]quinolinone Analogues via CoCl2/AgSbF6-Catalyzed Cyclization of Unactivated N,O-Acetals with Olefins October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01374G, PaperBangguo Wei, Xin Li, Yu Zhang, Yu-Ying Zhang, Chang-Mei Si, Qiao-E WangA convenient method to access functionalized tetrahydropyrrolo[1,2-a]quinolinone skeletons has been achieved through a CoCl2/AgSbF6-catalyzed Povarov reaction of unactivated N-Ar N,O-acetals with styrene-type olefins. As a result, a series of 5-substituted...The content of this RSS Feed (c) The […]Bangguo Wei
- Catalyst-free C−H Bond Halogenation/Imidation of N-heterocycle October 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01463H, CommunicationMiao Liu, Xueying Zhang, Nan Li, Xu Zhang, Congyong Zhao, Xiaobao Shen, Hongbin Zhai, Fufang WuThe application of N-halosuccinimides (NXS) as "nucleophilic" nitrogen sources in organic transformations represents an emerging and promising area of research. This work utilized the two key intermediates-X-radicals and N-radicals-generated synchronously...The content of this […]Miao Liu
- Diastereoselective Amidoboronate Formation and Transformation from a rac to a Different meso Amidoboronate via Dynamic C-C Bonds October 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01479D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patrick Harders, Tim Raeker, Lorenz Pietsch, Christian Nather, Bernd Hartke, Anna McConnellAmidoboronates synthesized through the reductive coupling of iminoboronates with cobaltocene in DMSO form as mixtures of up to three isomers (rac5, rac6 […]Patrick Harders
- Efficient and specific DNA-targeting using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes October 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01570G, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Michaela E Everly, Patrick J. HrdlickaDNA-targeting properties of heteroduplexes between intercalator-functionalized oligonucleotides and various Xeno RNAs (i.e., LNA/MOE mixmers, or fully modified MOE, O2'-Me, or 2'-F strands) are disclosed. Chimeric Invader:LNA/MOE probes and […]Michaela E Everly
- Stereochemical revision of brevipetins E and F: ellagitannin dimers with opposite hexahydroxydiphenoyl atropisomerism October 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01323B, PaperYosuke Matsuo, Ryo Ohtsuka, Yoshinori Saito, Koji Yamada, Takashi Tanaka, Fumika YakushijiBrevipetins E and F, ellagitannin dimers from Cleidion brevipetiolatum, were originally reported to bear both a 3,4-(Ra)-hexahydroxydiphenoyl (HHDP)-glucopyranose and a 3,4-(Ra)-HHDP-rhamnopyranose moiety. However, a detailed reevaluation of the reported electronic...The content of this RSS Feed (c) The […]Yosuke Matsuo
- Dioxazolones mediated cyclization reactions through C-H activation October 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01340B, Review ArticleMing Zhang3-Substituted 1,4,2-dioxazol-5-ones, also known as dioxazolones, are emerging amidation reagents that can be converted to N-acyl nitrenes in transition-metal-catalyzed amidation reactions. This review highlights dioxazolones mediated two-component cyclization reactions via...The content of this RSS Feed (c) The Royal Society of ChemistryMing Zhang
- TBAI (tetrabutylammonium iodide) Promoted Synthesis of Thioenamines through the C-S Bond Formation Starting from Enaminones and Thiosulfonates October 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01371B, PaperMeng-Ran Chang, Yu-Xi Wu, He-Yi Li, Yao-Yao Li, Jing-Jing Cui, Chi Ruan, Zhi-Peng Guan, Qing-Wen Han, Zhi-Bing DongA TBAI-mediated protocol for constructing C(sp²)-S bonds at the α-position of enaminones has been developed, utilizing odorless thiosulfonates as the organosulfur source. This approach efficiently synthesizes multifunctional thioenaminones with high...The content […]Meng-Ran Chang
- A Lewis/Brønsted Acid-Mediated Route to Furans from Nitroalkenes and Enol Ethers October 14, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01200G, PaperAlexander V. Zhirov, Evgeny Pospelov, Alexey Yu. SukhorukovA novel approach to tri- and tetra-substituted furans via a Brønsted acid-mediated ring contraction of readily available 1,2-oxazine N-oxides is reported. The method provides a two-step access to polysubstituted furans...The content of this RSS Feed (c) The Royal Society of ChemistryAlexander V. Zhirov
- A review of molecular probes for nickel(II) ion sensing October 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01388G, Review ArticleSefiu Olalekan OlaleyeThis review provides a critical and comprehensive analysis of colorimetric and fluorescent receptors for Ni(II) detection published between 2006 and 2024. The study also describes the current research landscape using a bibliometric approach.To cite this article before page numbers are assigned, use the DOI form […]Sefiu Olalekan Olaleye
- Introduction to foldamers October 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90117K, EditorialMakoto Oba, Aya Tanatani, Jianfeng Cai, Peng TengMakoto Oba, Aya Tanatani, Jianfeng Cai and Peng Teng introduce the Organic & Biomolecular Chemistry themed issue on foldamers.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Makoto Oba
- A pyridine-promoted umpolung strategy for the α-amination of styrenes via pyridinium salt intermediates October 13, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01405K, CommunicationWeibin Fan, Shahid Ali, Xiaozhong Wang, Liyan Dai, Jianhai Yang, Jia GuoPyridine served as a novel catalyst promoting the umpolung α-amination of styrenes. Umpolung of α-C in styrenes is achieved by pyridination, and depyridination will give the α-amination products.To cite this article before page numbers are assigned, use […]Weibin Fan
- Tuning rotational barriers through substituent modification in catechol-diyl molecular gyrotops October 13, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01474C, PaperHyu Kishii, Yusuke Inagaki, Kazuaki Ohara, Kentaro Yamaguchi, Wataru SetakaThe synthesis and characterization of catechol-3,6-diyl-based molecular gyrotops, in which VT-NMR revealed controllable phenylene rotor dynamics. Systematic tuning of alkoxy substituents modulated the rotational energy barriers.To cite this article before page numbers are assigned, use the DOI form of […]Hyu Kishii
- Diastereoselective spirocyclopropanation of (E)-2-ylidene-3-cyclohexenones and sulfur ylides October 13, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01383F, CommunicationZheng-Yan Li, Xing Zheng, Yi-Na Ma, Mingwei Yuan, Yin Zhang, Lin Jiang, Minglong YuanA diastereoselective [2 + 1] annulation reaction for synthesis of spirocyclopropane-fused 3-cyclohexenone derivatives has been established, utilizing easily preparable (E)-2-ylidene-3-cyclohexenones and stabilized sulfur ylides.To cite this article before page numbers are assigned, use the DOI […]Zheng-Yan Li
- Tumor-targeted fluorescent probes for the detection of hNQO1 in cancer cells October 12, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01491C, PaperLangping Zhou, Xinyang Xie, Weijie Chang, Weibing Zhang, Junhong QianFluorescent probes for single analyte might produce "false-positive" signals because the levels of the biomarkers could be up-regulated by some external factors such as drug stimulation, hypoxia, radiation, etc. Tumor-targeted...The content of this RSS Feed (c) The Royal Society […]Langping Zhou
- Selective electrochemical trifluoromethylation of arylamide- or aryl-substituted pyrrole derivatives October 12, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01482D, PaperZhanshuo Zhang, Yangkai Dong, Yaxin Liu, Jingrui Fang, Yuchen Li, Zeya Xu, Yulei ZhaoSelective electrochemical trifluoromethylation for pyrroles, particularly those containing additional aryl groups.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Zhanshuo Zhang
- Synthesis of naphth[2,1-a]azulenes via [8 + 2] cycloaddition of 2H-cyclohepta[b]furan-2-ones, and their reactivity, optical, and structural properties October 12, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01492A, PaperTaku Shoji, Akari Yamazaki, Miku Yoshida, Masafumi Yasunami (Deceased), Shigeki Mori, Tetsuo Okujima, Takumi Kamayachi, Ikumi Uchiyama, Ryuta Sekiguchi, Shunji ItoA concise and efficient synthetic route to naphth[2,1-a]azulenes was developed via [8 + 2] cycloaddition of 2H-cyclohepta[b]furan-2-ones with enamines or a silyl enol ether derived from α-tetralones.To cite […]Taku Shoji
- A chimeric enediyne for targeted degradation of a tumor-associated protein October 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01344E, CommunicationFangxu Pu, Xuejie Li, Haonan Cheng, Jiaming Lan, Aiguo HuPROTEC represents a novel platform that operates independently of cellular protein degradation machinery for the targeted degradation of a tumor-associated protein.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Fangxu Pu
- Digold photosensitizer for visible light [2+2] cycloaddition and E/Z isomerization reactions October 16, 2025
