RSC – Org. Biomol. Chem. latest articles- Tuning Rotational Barriers through Substituent Modification in Catechol-Diyl Molecular Gyrotops October 13, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01474C, PaperHyu Kishii, Yusuke Inagaki, Kazuaki Ohara, Kentaro Yamaguchi, Wataru SetakaMacrocage molecules bearing a bridged π-electron system represent a unique platform for molecular gyrotops, in which the π-electron system acts as an internal rotor confined within a cage. Here, we...The content of this RSS Feed (c) The Royal Society […]Hyu Kishii
- Pyridine promoted umpolung strategy for the α-amination of styrenes via pyridinium salt intermediates October 13, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01405K, CommunicationWeibin Fan, Shahid Ali, Xiaozhong Wang, Liyan Dai, Jianhai Yang, Jia GuoPyridine as a novel catalyst promotes umpolung α-amination of styrenes. Umpolung of α-C in styrene is achieved by the formation of (α-phenylvinyl)pyridinium, and depyridination will give the α-amination products. 23...The content of this RSS Feed (c) The […]Weibin Fan
- Diastereoselective spirocyclopropanation of (E)-2-ylidene-3-cyclohexenones and sulfur ylides October 13, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01383F, CommunicationZheng-Yan Li, Xing Zheng, Yi-Na Ma, Mingwei Yuan, Yin Zhang, Lin Jiang, Minglong YuanA diastereoselective [2 + 1] annulation reaction for synthesis of spirocyclopropane-fused 3-cyclohexenone derivatives has been established, utilizing easily preparable (E)-2-ylidene-3-cyclohexenones and stabilized sulfur ylides.To cite this article before page numbers are assigned, use the DOI […]Zheng-Yan Li
- Synthesis of naphth[2,1-a]azulenes via [8 + 2] cycloaddition of 2Hcyclohepta[b]furan-2-ones, and their reactivity, optical, and structural properties October 12, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01492A, PaperTaku Shoji, Akari Yamazaki, Miku Yoshida, Masafumi Yasunami, Takumi Kamayachi, Ikumi Uchiyama, Shigeki Mori, Tetsuo Okujima, Ryuta Sekiguchi, Shunji ItoA concise and efficient synthetic route to naphth[2,1-a]azulenes was developed via [8 + 2] cycloaddition of 2Hcyclohepta[b]furan-2-ones with enamines or a silyl enol ether derived from α-tetralones. A diverse […]Taku Shoji
- Selective Electrochemical Trifluoromethylation of Arylamide-or Aryl-substituted Pyrrole Derivatives † October 12, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01482D, PaperZhanshuo Zhang, Yangkai Dong, Yaxin Liu, Jingrui Fang, Yuchen Li, Zeya Xu, Yulei ZhaoA selective electrochemical trifluoromethylation reaction for pyrroles, particularly those containing additional aryl groups, has been developed for the synthesis of 2-trifluoromethylpyrrole derivatives. The cost-effective CF3SO2Na has been employed in the...The content of this RSS Feed […]Zhanshuo Zhang
- Tumor-targeted fluorescent probes for the detection of hNQO1 in cancer cells October 12, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01491C, PaperLangping Zhou, Xinyang Xie, Weijie Chang, Weibing Zhang, Junhong QianFluorescent probes for single analyte might produce "false-positive" signals because the levels of the biomarkers could be up-regulated by some external factors such as drug stimulation, hypoxia, radiation, etc. Tumor-targeted...The content of this RSS Feed (c) The Royal Society […]Langping Zhou
- Chimeric enediyne for targeted degradation of tumor-associated protein October 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01344E, CommunicationFangxu Pu, Xuejie Li, Haonan Cheng, Jiaming Lan, Aiguo HuProtein-radical-oxidation targeting enediyne chimera (PROTEC) comprising an enediyne warhead and a protein-targeting moiety was developed for the selective degradation of tumor-associated protein. PROTEC operates by forming a binary complex with...The content of this RSS Feed (c) The Royal Society […]Fangxu Pu
- Transition-metal and Photocatalyst-free Oxidative Cleavage of Aryl alkynes with PIDA/Iminoiodinanes in Visible Light October 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01318F, PaperNidhi Jain, Rajat JoshiWe report a transition-metal and photocatalyst-free method for the oxidative cleavage of aryl alkynes using phenyliodine diacetate (PIDA) and iminoiodinane in visible light. Various terminal and internal aryl alkynes furnish...The content of this RSS Feed (c) The Royal Society of ChemistryNidhi Jain
- Biocatalytic synthesis of β-hydroxy tryptophan regioisomers October 8, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01304F, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Samantha K. Bruffy, Hunter Samuel, Holly A. Weilbaker, Andrew R. BullerWe report a biocatalytic strategy to access novel β-hydroxy L-tryptophan regioisomers using an L-threonine transaldolase.To cite this article before page numbers are assigned, […]Samantha K. Bruffy
- Co(III)-catalyzed allylation reaction of 2-alkenylpyridines with 2-vinylaziridines: access to 1,4-dienes October 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01343G, PaperHong Zeng, Zhong-Xia WangA Cp*(CO)CoI2-catalyzed C–H allylation of 2-alkenylpyridines with 2-vinylaziridines is described. This method provides an efficient access to the synthetically useful 1,4-diene skeletons. The approach features simple reaction system, nitrogen-containing group...The content of this RSS Feed (c) The Royal Society of ChemistryHong Zeng
- Six-membered cyclic sulfamidate imines: functionalization and cyclization reactions October 8, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01262G, Review ArticleFatemeh Doraghi, Mohammad Hadi Edareh, Bagher Larijani, Mohammad MahdaviCyclic N-sulfaidate imines are important motifs in natural products and pharmaceuticals. This review describes transformations of cyclic sulfamidate imines under transition metal catalysis, and metal-free conditions.To cite this article before page numbers are assigned, use the DOI form of […]Fatemeh Doraghi
- Pyreno-1,2,4-Triazines as Multifunctional Luminogenic Click Reagents October 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01512J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hind Alshaikh, Jonathan Parsons, Gary Askwith, Catherine Emma Nicholson, Michael Edward Deary, Mark Sims, Valery Nikolaevich KozhevnikovSeveral examples of 1,2,4-triazines that contain a pyrene fragment attached to the C5 position and a carbonyl […]Hind Alshaikh
- Silver-Catalyzed Synthesis of Polyfunctionalized 1,7- and 2,7- Benzonaphthyridine Scaffolds and their Access to Perlolidine Derivatives October 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01410G, PaperKirti Vashishtha, Kapil Chahal, Namita Bhoi, Donamol Tomy, Sridhar Balasubramanian, Manjula Alla, Kallu Rajender ReddyA regio- and chemoselective silver-catalyzed one-pot synthesis of benzo[b][1,7]- and benzo[c][2,7]-naphthyridines has been developed via a sequential Michael addition and silver-mediated cyclization strategy. The protocol exhibits excellent selectivity, high yields,...The content of this RSS […]Kirti Vashishtha
- Synthesis and Evaluation of Naphthoquinone-based Probes for Activity-based Protein Profiling of Oxidoreductases October 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01320H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Leo Krammer, Barbara Darnhofer, Rolf BreinbauerActivity-based protein profiling (ABPP) has become a highly valuable proteomic technique over the past decades especially in the investigation of hydrolytic enzymes. Oxidoreductases have so far received less […]Leo Krammer
- Photo-induced radical trifluoromethylation/dearomatization of 3-substituted indoles October 7, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01103E, PaperYuyu Lv, Zhoubin Deng, Zhijun Zhu, Xiaopeng Hai, Junjiao Wang, Ke-Hu Wang, Danfeng Huang, Yulai Hu3,3-Spirocyclic 2-trifluoromethylindolines have been synthesized via a visible-light-induced cascade radical trifluoromethylation/cyclization/dearomatization reaction between 3-substituted indoles and CF3Br.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Yuyu Lv
- Molybdenum Catalyzed Acceptorless Dehydrogenative Approach for Quinoline Synthesis Using Amino Alcohol October 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01409C, PaperVaishnavi Atreya, Anirban Sil, Debangsu Sil, Subrata ChakrabortyWe report here bidentate phosphine-ligand based molybdenum π-allyl complex [Mo(CO)2(η3-C3H5)(DPPE)Cl] (Mo-1; DPPE ={1,2-bis(diphenylphosphino)ethane}) in the dehydrogenative annulation of 2-aminobenzyl alcohol with a wide variety of methylketones to form N-heterocycle quinoline...The content of this RSS Feed (c) The Royal Society of ChemistryVaishnavi Atreya
- Phenoxysulfonyl Azide: A New Diazo-transfer Reagent for Metal–Free Conversion of Amines to Azides October 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01124H, PaperSungduk Gwak, Ji Hye Lee, You Jeong You, Hyeok-Jun Kwon, Hogyu HanPhenoxysulfonyl azide (PSA, 1) was synthesized from 1,1'-sulfonylbis(2-methyl-1H-imidazole) (2) and studied for its diazo-transfer reactivity. The reaction with 1 was found to convert primary amines 3 into their corresponding azides...The content of this RSS Feed (c) The […]Sungduk Gwak
- Iron Catalysis Enables Mild C–Se Bond Formation via Decarboxylative Selenylation October 7, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01402F, CommunicationXixi Hu, Wenhao Li, Xin Huang, Qingkun Ma, Hui Liu, Yu-Zhao Wang, Lizhi ZhangSelenium-containing compounds are pivotal in bioactive molecules, yet efficient C–Se bond formation is of significant interest in organic synthesis. We report an iron-catalyzed decarboxylative selenylation of alkyl carboxylic acids with...The content of this RSS Feed […]Xixi Hu
- Base-promoted tandem synthesis of nitrogen-containing compounds: MN(SiMe3)2 as potential nitrogen sources October 7, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01461A, Review ArticleDong Zou, Jie YingMN(SiMe3)2 can function both as a base for deprotonation and as an amino source, thereby contributing to the synthesis of nitrogen-containing compounds and achieving efficient atom utilization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Dong Zou
- Recent advances in visible-light-driven photocatalytic synthesis of biologically active N-heterocycles October 6, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01411E, Review ArticleSurabhi Sinha, Praveen P. Singh, Deepak Kumar, Vishal SrivastavaHeterocycles consisting nitrogen are a potent bioactive compounds, that have extensive application in agrochemistry, materials research, and medicinal chemistry. An overview of the synthesis of N-heterocycles using visible-light photoredox catalysis has been provided in this article.To cite this article before […]Surabhi Sinha
- Tuning Rotational Barriers through Substituent Modification in Catechol-Diyl Molecular Gyrotops October 13, 2025
