RSC – Org. Biomol. Chem. latest articles- Synthesis of a Naphthalimide-Functionalized Polymethacrylate: A Turn-on Fluorescent Probe for Sulfinic Acids via Covalent Bond Formation August 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00967G, PaperHiroki Tanimoto, Aoi Otsuki, Tomohiro TakenoriA fluorescent naphthalimide azocarboxylate was successfully tethered to a polymethacrylate backbone. The resulting polymeric material exhibits efficient turn-on fluorescence upon sulfinate addition onto the azo moiety forming covalent bonding, with...The content of this RSS Feed (c) The Royal Society of ChemistryHiroki Tanimoto
- Pro-fluorescent ethynylthiophene-based o-nitrobenzyl photolabile protecting group for hydroxamic acid synthesis August 5, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00859J, PaperAlbert D. Campbell, Lingaraju Gorla, Ophelia Adjei-Sah, Blaise Williams, Stephen O. Ajagbe, Samer Gozem, Mohammad A. Halim, Carl Jacky Saint-LouisWe report two novel pro-fluorescent, ethynylthiophene-based o-nitrobenzyl photolabile protecting groups that absorb visible light and enable real-time visualization of hydroxamic acid release through a fluorescent nitrosoketone by-product.To cite this […]Albert D. Campbell
- Copper-Catalyzed Amide Synthesis via Transient Amine Activation with Isothiocyanates August 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01008J, PaperPinyong Zhong, Kunming Liu, Fu-Min Liao, Bin Huang, Min Yang, Jin-Biao LiuThe development of catalytic amide synthesis strategies without carboxylic acid preactivation remains a formidable challenge. Herein, we report a copper-catalyzed method enabling direct amidation via transient activation of amines using...The content of this RSS Feed (c) The […]Pinyong Zhong
- Recent Advances in Chiral Phosphoric Acids for Asymmetric organocatalysis: A Catalyst Design Perspective August 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00719D, Review ArticlePeng-Fei Zhao, Ke Wang, Jia-Xu Wen, Zhang-Mei-Duo Zhu, Hua Zhang, Zi-Heng Wang, Yu-Xin Liao, Chao-Shan Da, Zhi-Hong DuAsymmetric catalysis, as a core technique in organic synthetic chemistry, can efficiently and precisely construct organic compounds with specific stereochemical structures and plays an indispensable role in many fields such...The […]Peng-Fei Zhao
- Gold-Catalyzed Umpolung Sonogashira-Type Coupling of Boronic Acids with Alkynyl Iodine(III) Reagents August 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01010A, PaperDan Xiao, Huanjun Zhang, Junxiao Huo, Qin Zhou, Chunyu Han, Jinhua YangA gold-catalyzed C(sp)–C(sp2) cross-coupling reaction between hypervalent iodine(III) reagents and boronic acids has been developed, enabling the efficient synthesis of alkyne derivatives. This methodology features a broad substrate scope, high...The content of this RSS Feed (c) The […]Dan Xiao
- Microwave - Assisted Direct Amidation of Thioesters: A Green Approach August 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01014D, PaperHan Cao, Yijun Shi, Peng Yan, Fusheng Bie, Jie MaDirect amidation of thioesters represents a virtually nonclassical route in the synthesis of amides, frequently encountering limitations due to poor compatibility between thioester and amine structures as well as poor...The content of this RSS Feed (c) The Royal Society […]Han Cao
- Synthesis of 4-(arylthio)isoquinolin-1(2H)-ones via TBHP-mediated sequential amidation/thioetherification of N-alkylisoquinolinium salts August 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01074H, CommunicationJinhui Cai, Chuanquan Chu, Jinhui Peng, Lijuan Jin, Yilin Chen , Dahan Wang, Jinbing Liu, Junyuan Tang, Zi Yang, Mingming YuHere, a simple, efficient, and practical method for the assembly of 4-(arylthio)isoquinolin-1(2H)-ones via TBHP-mediated 1,4-difunctionalization of N-alkylisoquinolinium iodide salts under metal-free conditions is reported. This strategy is highlighted […]Jinhui Cai
- NaIO₄--Driven Oxidative Dimerization and Cu(I)-Catalyzed Oxidative Decarbonylation: Modular Synthesis of 1,2-Naphthoquinones and Aryl Naphtho[2,b]furans August 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01064K, PaperMudassir Ahmad Lone, Gowhar Ahmad Rather, Amir Rashid Tarray, Waseem Iqbal Lone, Showkat RashidSodium metaperiodate-mediated oxidative C–C homocoupling of diverse β-naphthols to 1,2-naphthoquinones in aqueous medium, using 18-crown-6 as an additive, is reported. Subsequent Cu(I) chloride-assisted decarbonylative oxidation of the resulting 1,2-diketones under...The content of this RSS Feed […]Mudassir Ahmad Lone
- Dimethyl(methylthio)sulfonium Salt Triggered Dithiocarbamation of Alkenes with CS2 and Amines August 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01043H, PaperSha Peng, Cheng-Mei Qi, Li-Mei Duan, Ding Luo, Lu-Can Cheng, Si-Si Tian, Li-Hua Yang, Long-Yong XieIn this work, a straightforward and practical four-component reaction involving alkenes, CS2, amines, and dimethyl(methylthio)sulfonium trifluoromethanesulfonate (DMTSM) is reported. This reaction enables the convenient synthesis of various S-alkyl dithiocarbamates in...The content of this […]Sha Peng
- Anti-adipogenic Effects of N-Acetyltyramine from Termite-Associated Streptomyces August 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01062D, PaperSe Yun Jeong, Mei Tong He, Μihyang Kim, Ki-Hwan Nam, Michael Poulsen, Christine Beemelmanns, Ki Sung Kang, Ki Hyun KimObesity remains a global health challenge, and novel small-molecule modulators of adipogenesis are urgently needed. Here, we investigated the anti-adipogenic potential of metabolites isolated from termite-associated Streptomyces sp. M45. […]Se Yun Jeong
- Efficient Synthesis of Functionalized Alkylidenephthalides, Butenolides, Pyranones, and Isocoumarins via I₂–PPh₃: Synthesis of Thunberginols A and F August 3, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01153A, CommunicationRohitkumar V Abhang, Prathmesh N Bhagwat, Kishor Laxman HandoreA simple and efficient synthesis of functionalized alkylidenephthalides, butenolides, pyranones, and isocoumarins were achieved using I2-PPh3-Et3N reagent combination. The products obtained through this methods act as versatile components in organic...The content of this RSS Feed (c) The Royal Society of […]Rohitkumar V Abhang
- Recent Advances in Radical Addition/Divergent Cyclization of Ynones July 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01044F, Review ArticleYan Zhang, Liji Gu, Ruoyang Xu, Weiwei HuanOver the past decade, designing new radical reactions has emergered as an increasingly-powerful strategy to construct complex molecular scaffolds, which usually features divergent predictable reaction outcome, diverse radical precursors, and...The content of this RSS Feed (c) The Royal Society of […]Yan Zhang
- Nitromethane Extrusion Reaction for Synthesis of Polycyclic Benzimidazoheterocycles July 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00862J, PaperPin-Hui Lin, Stalindurai Kesavan, Si-Yuan Chen, Teau-Jiuan Liou, Ding-Yah YangA facile base-promoted annulation of diamines with 4-chloro-3-nitrocoumarins or 4-chloro-3-nitroquinolin-2(1H)-ones to afford 6H-benzimidazo[1,2-c][1,3]benzoxazin-6-ones or benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-ones in moderate to good yields is reported. These metal- and triphosgene-free reactions presumably proceed by...The content of this RSS Feed (c) The Royal Society […]Pin-Hui Lin
- Novel ring-opening rearrangement reactions of N-cyclopropyl-amides: access to N-(2-chloropropyl)amides and 5-methyl-2-oxazolines July 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01040C, CommunicationCongcong Wan, Hongling Wang, Xiang ZhangA ring-opening rearrangement reaction of N-cyclopropylamide is shown to occur in the presence of AlCl3. The mechanism is proposed herein involving the “Heine-type” aziridine intermediate and C-Cl or C-O bond...The content of this RSS Feed (c) The Royal Society of ChemistryCongcong Wan
- Cu2O-mediated regio- and stereoselective one-pot synthesis of (Z)-3-ylidenephthalides from 2-iodobenzoic acids and terminal alkynes July 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00808E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ahmed R. Ali, Longqin HuA series of substituted (Z)-3-ylidenephthalides was synthesized from 2-iodobenzoic acids and various terminal alkynes in the presence of Cu2O in DMF at 100–130 °C.To cite this article before page […]Ahmed R. Ali
- Pd-NHC-catalyzed N-acylation of sulfoximines with aromatic esters July 29, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00981B, CommunicationYuanfang Zhong, Linjie YangNHC-Pd-catalyzed cross-coupling of NH-sulfoximines with aromatic esters; aromatic esters as the 'acylation' sources; avoids using a stoichiometric amount of additives such as B(OH)3, Boc2O, oxidative agents, etc; Wide substrate scope.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Yuanfang Zhong
- Recent Advances in the Synthesis of Fluorinated Heterocycles and A Close Look on the Recent FDA-Approved Fluorinated Drugs July 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00997A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sayan Mukherjee, Ujala Rani, Girish Chandra, Shantanu PalSince the date of inception of artificial drugs and agrochemicals to human society, the presence of a heterocyclic framework in the drug dominates and this […]Sayan Mukherjee
- Ruthenium-catalyzed C(sp2)−H ortho-heteroarylation of phthalazin-1(2H)-one using thiophenes by cross-dehydrogenative coupling July 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01111F, CommunicationAlagumalai Ramkumar, Thirumanavelan GandhiThe cross-dehydrogenative coupling reactions gained supreme importance owing to their synthetic efficiency in accessing simple to complex organic molecules. Herein, we report a Ru(II)-catalyzed directing group-assisted CDC reaction between phthalazin-1(2H)-one...The content of this RSS Feed (c) The Royal Society of ChemistryAlagumalai Ramkumar
- TCCA/PhSH-Mediated regioselective hydroethoxylation and hydromethoxylation of allenamides via a radical process. July 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00698H, PaperQingsong Liu, Gele Jiri, Xingyao She, Zhi-Gang Zhao, Xiao-Xiao LiAn efficient TCCA/PhSH-mediated regioselective hydroethoxylation and hydromethoxylation of allenamides via a radical process was developed to create a workable route to γ-oxygenated enamides. This process is highly regioselective, affording (E)-γ-oxygenated...The content of this RSS Feed (c) The Royal Society […]Qingsong Liu
- Efficient photocatalytic synthesis of benzylhydrazine July 29, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00771B, CommunicationYuhui Zhang, Fei Zeng, Yangyang Li, Meiqi Zhou, Jiafan Wang, Bingzhen MaSynthesis of benzylhydrazine via dehydroxymethylation–hydrazination of unactivated phenylethanol analogues under dual photocatalysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Yuhui Zhang
- Synthesis of a Naphthalimide-Functionalized Polymethacrylate: A Turn-on Fluorescent Probe for Sulfinic Acids via Covalent Bond Formation August 5, 2025
