RSC – Org. Biomol. Chem. latest articles- The Ugi-Joullié three-component (UJ-3CR) and related reactions. Recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds February 12, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB02009C, Review ArticleNatalia A. Lenarduzzi D'emilio, Paula K Paz Armero, Arturo R. Mendoza Salgado, Teodoro S Kaufman, Sebastian O. Simonetti, Andrea B.J. Bracca, Enrique L. LarghiThe Ugi-Joullié three-component reaction evolved from the classic Ugi four-component reaction and enables the facile and efficient formation of polysubstituted nitrogen heterocycles from cyclic […]Natalia A. Lenarduzzi D'emilio
- Visible-Light-Induced C-H Trifluoromethylation of Several Nitrogen Heterocycles with CF3Br February 12, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB02002F, PaperYuyu Lv, Zhijun Zhu, Xiaopeng Hai, Xinyi Li, Junjiao Wang, Ke-Hu Wang, Danfeng Huang, Yulai HuA visible-light-induced effective strategy for C-H trifluoromethylation of nitrogen heterocycles with CF3Br in the presence of K2CO3 has been developed, which efficiently provided trifluoromethylated nitrogen heterocycles, including indoles, imidazoles, indazoles,...The content of this […]Yuyu Lv
- Transition-Metal-Free [4+2] Cyclocondensation of Diaryliodonium salts Accessing Phenazine, Phenothiazine, Phenoxazine and Dioxane Derivatives February 12, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00012F, CommunicationBin Liu, Tao Qin, He ye zhou, Shaoqing Wang, Weilin Lan, Chengkai YinWe report here a versatile transition-metal-free synthesis of diverse heterocycles from novel ortho-fluorinated nitro-diaryliodonium salts. The protocol shows broad functional-group tolerance and supports late-stage derivatization, as demonstrated by the synthesis...The content of this RSS Feed (c) […]Bin Liu
- Development of the synthetic route to 5-hydroxymethyl tolterodine, a key synthetic intermediate of Toviaz, via an organic solvent-free Rh-catalyzed asymmetric 1,4-addition February 12, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01887K, CommunicationAki Hirasawa, Hiroki Shibata, Gaku Okamoto, Toshihide Takemoto, Katayama Takeaki, Toshiyuki Oshiki, Toshinobu KorenagaA synthetic route to Toviaz (fesoterodine fumarate) and its key intermediate 5-hydroxymethyl tolterodine (5-HMT) has been markedly improved by employing an organic solvent-free rhodium-catalyzed asymmetric 1,4-addition. Under these conditions, the...The content of this RSS Feed […]Aki Hirasawa
- Regioselective House–Meinwald Rearrangement in Oxindoles: Access to Substituted Quinolinones February 12, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00128A, CommunicationB. Mohan, K. S. Sandhya, Ramakrishnan Thushara, Athira Chithralekha Santhoshkumar, Liyo Vincent K, Cherumuttathu Hariharan Suresh, Jayamurthy Purushothaman, B. S. SasidharHouse–Meinwald rearrangement of oxindole substrates facilitates a one-pot synthesis of 3-substituted 4-hydroxyquinoline-2-ones and quinoline-2,4-diones under EBHP and base-mediated conditions is reported. This transformation proceeds through a well-defined sequence […]B. Mohan
- Synthesis of α-chloro-β-ketoesters via ytterbium(III) triflate-mediated decarboxylative Claisen-type condensation February 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01966D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yihao Shi, Isao Yoshikawa, Akihiro Sakama, Kazuaki KudoA Yb(OTf)3-mediated decarboxylative Claisen-type condensation is established to access α-chloro-β-ketoesters. By proceeding under mild conditions, this method delivers products in 78–95% yield while circumventing the functional-group […]Yihao Shi
- Sodium halide-switchable divergent electrochemical synthesis of sulfonyl chlorides and thiosulfonates from thiols February 11, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01939G, PaperFateh Golmoradi, Amin Rostami, Farzad NikpourElectrochemical synthesis of sulfonyl chlorides and thiosulfonates featuring accessible materials, cheap electrodes, and a broad substrate scope. Gram-scale production and product switchability are demonstrated.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Fateh Golmoradi
- Enantioselective Synthesis of Antibiotic Inducing Gamma-Butenolides from Streptomyces rochei and Derivatives February 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01862E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Haylie E Hennigan, Manuela Frias-Gomez, Kylie G Castator, Lauren E Wilbanks, Caroline Zu, Gracie Sanders, Elizabeth ParkinsonGiven the challenges of discovering new natural products, further investigations into the regulatory systems that control their […]Haylie E Hennigan
- Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension February 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00071A, PaperYao-Hui Gao, Xiao Pan, Qin-Lian Wang, Xue-Feng Bao, Ping Dai, Sheng-Ying Qin, Shao-Yang Li, Guo-Dong Chen, Gao-Qian Wang, Jian-Ming Lv, Dan Hu, Hao GaoFuranosteroids are a structurally distinctive class of fungal metabolites with significant biological activities, particularly well-known as potent phosphatidylinositol 3-kinase inhibitors. Previously, we have elucidated the […]Yao-Hui Gao
- Palladium-catalyzed difluoromethylcarbonylation of aryl iodides February 11, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00006A, CommunicationYijie Wei, Jinxu Dong, Xiaohong Wen, Xiaodong Xiong, Xiaojun ZengWe report a palladium-catalyzed carbonylative difluoromethylation of aryl iodides with (DMPU)2Zn(CF2H)2 under 1 atm CO, giving aryl difluoromethyl ketones in good yields, with broad tolerance, late-stage modification, and facile derivatization.To cite this article before page numbers are assigned, use the […]Yijie Wei
- DNA-Based Cooperative Games: An Interactive Collective Decision-Making Architecture February 11, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00124F, CommunicationYao Yao, Xiaokang Zhang, Ranfeng Wu, Shuang Cui, Lijun Sun, Bin Wang, Qiang ZhangGame theory provides a architecture for multi-agent strategic interactions, while DNA computing offers programmable, parallel molecular-scale operations, enabling unique “molecular gaming” systems beyond silicon-based architectures. Current approaches, primarily using DNA...The content of this RSS Feed […]Yao Yao
- P4O10/TfOH Assisted One Pot Access to 8-Oxoprotoberbines February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01984B, PaperSantosh G Tilve, Madhuri M Gaikwad, HARI KRISHNA KADAMThis study describes an efficient one-pot strategy for the synthesis of a series of thirteen 8-oxoprotoberberine alkaloids through cascade process involving carbonyl activation and regioselective intramolecular cyclization. The synthesis demonstrates...The content of this RSS Feed (c) The Royal Society of […]Santosh G Tilve
- Photo-induced peroxy-pyridylation of alkenes via metal-free photocatalysis February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01923K, PaperYao Lin, Cai Gao, Chen-Xiang Guo, Zhen-Qiang Zhang, Zhuang-ping ZhanA metal-free photocatalytic peroxy-pyridylation of alkenes with oxime ester, and tert-Butyl hydroperoxide as substrates is reported. Under visible-light irradiation, the protocol achieves simultaneous introduction of both a peroxy group and...The content of this RSS Feed (c) The Royal Society […]Yao Lin
- Synthesis of Diverse Substituted Pyrimidines through Cu Catalyst-Controlled Ts Group's Elimination and Reinsertion Pathway from 2H-Azirines with TosMICs February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01962A, PaperWen Cheng, Mengfan Li, hao tang, yuxi wang, qiurou yu, Xiaoli Bao, Yun-Hui Zhao, Weiyin YiTwo copper-controlled reactions of 2H-azirines with TosMICs have been developed that provide two efficient and modular approachs to diverse substituted pyrimidines with non electron-withdrawing substituents at the position 4 or...The content of this […]Wen Cheng
- (±)-Gnetuparin A: a pair of stilbene enantiomers from Gnetum parvifolium and their xanthine oxidase inhibitory activity February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00009F, PaperQinfeng Zhu, Qian Chen, BeiBei Gao, Ye Xue, Ling-Ling Yu, JunLi Ao, Guo-Bo Xu, Shanggao Liao(±)-Gnetuparin A (1a/1b), a pair of stilbene enantiomers characterized by a 6/5/5 tricyclic ring system, were isolated from the stems of Gnetum parvifolium. The racemic mixture of 1a/1b were separated...The content of this […]Qinfeng Zhu
- B(C₆F₅)₃/I₂ Co-Mediated Cascade [4 + 2]/[3 + 2] Cyclization to Spiroimidazolines February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01941A, PaperHuanyi Qiu, Jingxi Fang, Mingyan Guan, Surong Xie, Xi Chen, Qiuqi Zhang, Zhentao Pan, Yongmin MaA highly step- and atom-economical cascade [4 + 2]/[3 + 2] cyclization has been developed for the synthesis of structurally novel spiroimidazolines. Catalyzed by only 1 mol% B(C₆F₅)₃ in the...The content of this […]Huanyi Qiu
- Synthesis of α-trifluoromethyl-β-lactams via copper-catalyzed Kinugasa reaction of nitrones with 3,3,3-trifluoropropyne and their defluorination February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01913C, PaperShouxiong Chen, Peiqi Yang, Biqiong Hong, Fafu Yang, Zhiqiang WengAn efficient protocol for synthesizing α-trifluoromethyl-β-lactams through copper-catalyzed Kinugasa reaction of nitrones with in situ generated 3,3,3-trifluoropropyne. The reaction proceeds through generations the Cu(I) acetylide species, followed by a regioselective...The content of this RSS Feed (c) The Royal Society […]Shouxiong Chen
- Expeditious Synthesis of Multiglycopeptides with Heterogeneous Glycan Cores Derived from α-Dystroglycan Mucin-Like Domain February 10, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00013D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dror Ben Abba Amiel, Mattan HurevichGlycosylation is a post-translational modification prevalent in the majority of proteins. Many glycoproteins contain several glycosylation sites, often bearing different glycan moieties. The inherent difficulties of glycopeptide synthesis […]Dror Ben Abba Amiel
- A tertiary amine synthesis via a hydroxylamine alkylation/catalytic reduction sequence February 10, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01902H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniel Barriault, Nicholas M. Halliday, Sterling Renzoni, Huy M. Ly, Monica A. Gill, André M. BeaucheminA new route to N-methyl tertiary amines is reported, using an N-alkylation/catalytic N-oxide reduction sequence of secondary hydroxylamines.To […]Daniel Barriault
- Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition # February 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB02013A, PaperAshutosh Bedekar, Raymond J. Butcher, Astha DwivediA new class of chiral thiourea derivatives derived from amino acids has been developed that harness the dual influence of strong hydrogen bonding and stereogenic amino acid scaffolds. Both unsymmetrical...The content of this RSS Feed (c) The Royal Society of ChemistryAshutosh Bedekar
- The Ugi-Joullié three-component (UJ-3CR) and related reactions. Recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds February 12, 2026
