RSC – Org. Biomol. Chem. latest articles- Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids June 5, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00643D, PaperFeng Chen, Zhiqin Zhang, Jianwei Wang, Jiaxi Xu, Hongguang Du, Ning ChenA visible-light-driven, three-component coupling for the synthesis of N-aryl amino acids and unnatural peptides is described, which proceeds under mild, catalyst-and photocatalyst-free conditions-even under natural sunlight. Glyoxylates, anilines, and 4-alkyl...The content of this RSS Feed (c) The […]Feng Chen
- Metal-Ligand Cooperative Ni(II) Catalysis for One-Pot Access of Biologically Relevant Quinolines and Their Transfer Hydrogenation June 5, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00303F, PaperVirendra Kumar Chaudhary, Keshav Sharma, Prashant Kukreti, Sain Singh, Kaushik GhoshHerein, we present a square planar Ni(II) cooperative catalyst affixed by azo- and amido-based ligand that has been effectively employed for accessing highly substituted quinolines utilizing 2-aminoaryl alcohols with 2°-alcohols....The content of this RSS Feed (c) The Royal […]Virendra Kumar Chaudhary
- Synthesis of Enaminones Enabled by Potassium Persulfate Oxidative N-Dealkylation and Addition to Ynones June 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00759G, PaperYong Xiao, Li-Gang Kou, Bin-Xuan Zou, Qiong Jia, Yong-Qiang WangThe development of efficient and practical N-dealkylation methods stands as a long-sought goal in synthetic chemistry. Herein, we developed a convenient N-dealkylation reaction of tertiary amines enabled by the oxidation...The content of this RSS Feed (c) The Royal Society […]Yong Xiao
- A Sustainable Photocatalytic Regioselective Halogenation of 1-Alkyl/Benzyl-3-Phenylquinoxalin-2(1H)-ones in Aqueous Media June 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00384B, PaperMonika Monika, Prashant Kumar, Brajendra Kumar SinghA sustainable and regioselective protocol for mono-halogenation of 3-arylquinoxalin-2(1H)-ones has been developed, utilizing 1,3-dihalo-5,5-dimethylhydantoin derivatives as halogen sources. A dual catalytic system combining Pd(OAc)₂ and water-soluble Eosin Y was employed...The content of this RSS Feed (c) The Royal Society of ChemistryMonika Monika
- Sortase A-Mediated Hydrazinolysis Generates Homogeneous N-Terminal GL Proteins for OaAEP1-Catalyzed Bioconjugation June 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00719H, PaperJunjiang Li, Tingting Cui, Jian Sun, Yi-Ming LiOaAEP1-mediated ligation provides an effective platform for site-specific protein modification, but it needs to obtain homogeneous N-terminal Gly-Leu (GL) protein substrates. Here, we describe a Sortase A-mediated hydrazinolysis approach for...The content of this RSS Feed (c) The Royal Society of ChemistryJunjiang Li
- Bioinspired direct diversification of Pinus densiflora resin via an oxa-Diels-Alder reaction and its anti-neuroinflammatory effects in BV2 microglial cells June 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00452K, PaperVan-Hieu Mai, Seri Choi, Yunhui Che, Gi-Hyeon Seong, Jae S Park, Jin-Pyo An, Yun-Sil Lee, Won-Keun OhThe resin of Pinus densiflora (Pine resin) serves as a natural reservoir rich in abietane-type diterpenoids, a structurally diverse class of secondary metabolites with notable pharmacological potential. To enhance the...The content of […]Van-Hieu Mai
- Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes June 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00637J, PaperRambabu Kandukuri, Madhu Inapanuri, Nagaraju Naddi, Hari Prasad KokatlaA transition-metal-free rongalite-mediated strategy has been developed for the geminal difunctionalization of fluorene derivatives, enabling the efficient synthesis of (9-methyl-9H-fluoren-9-yl)methanols derivatives. In this transformation, rongalite plays a dual role as...The content of this RSS Feed (c) The Royal Society of […]Rambabu Kandukuri
- The Sulfo-Click Reaction: Expanding the Toolbox for Bioconjugation and Medicinal Chemistry June 4, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00609D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Michael Smietana, Romain Amador, Guillaume ClavéThe sulfo-click reaction, which relies on the chemoselective coupling of sulfonyl azides with thioacids to yield Nacylsulfonamides, has emerged as a powerful and versatile transformation in synthetic […]Michael Smietana
- Cu-catalyzed oxidative coupling of alkylarenes with tertiary C(sp3)–H bonds via C–H activation June 4, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00723F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gang Hong, Pradip D. Nahide, Wahiduddin G. Patel, Marisa C. KozlowskiEfficient Cu-catalyzed CDC of alkylarenes with tertiary C(sp3)–H Bonds via C–H activation.To cite this article before page numbers are assigned, use the DOI […]Gang Hong
- Direct C4-H Amination of Pyridines and Quinolines under Benign Conditions June 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00669H, PaperTong Han, Fenlian Xu, Xinqiao Nie, Dong WangExisting methods for the para-C-H amination of pyridines and quinolines are scarce and rely exclusively on indirect approaches. These typically involve initial installation of an amine surrogate or an aryl...The content of this RSS Feed (c) The Royal Society of ChemistryTong Han
- A Hydrido-Alkynyl-Prins Cyclization Using Isopropanol as Hydride Donor: Discovery, Scope and Mechanistic Study June 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00688D, PaperBeeraiah Baire, Ramesh Gollachinnamola, Surabhi MishraThe Alkynyl-Prins cyclization is a very important strategy in organic synthesis for the construction of cyclic frameworks and natural products, via vinyl carbocation intermediate under acid catalysis. Surprisingly, the alternate...The content of this RSS Feed (c) The Royal Society of ChemistryBeeraiah Baire
- HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes June 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00743K, CommunicationXiaochen Ji, Huawen Huang, Yixi ZhangCross-dehydrogenative coupling (CDC) reactions offer high atom economy and simple synthetic routes, and are widely employed for the coupling of heterocyclic rings. Herein, we report a transition-metal-free HBr-catalyzed aerobic CDC...The content of this RSS Feed (c) The Royal Society of ChemistryXiaochen Ji
- Application of a 1-(2-aryl)dicyclohexylphosphonium tetrafluoroborate ligand in the conjugated synthesis of heteroaryl biphenyls June 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00698A, PaperYue Hu, Wenjing Fu, Mengyu Zhou, Haoyue Xing, Sixuan Meng, Jian Chen, Qiong Chen, Rui Guo, Guang-Ao YuThe development of novel indenyl ligands for carbon–carbon coupling reactions is a longstanding challenge, especially those used to obtain more efficient products, reduce the catalytic dosage, and provide greener reaction...The content […]Yue Hu
- Temperature-Directed in situ Generation of Fluorobenzyl Radicals: Utilization for the Complete Fluorobenzylation of Tri-, and Tetramethylbenzenes June 3, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5OB01908G, PaperDharmveer Bhedi, Ramalingam ThirumoorthiOrganofluorine compounds have been broadly employed in the fields of pharmaceuticals, agrochemicals, and materials. Concurrently, the well-known star-shaped molecules, 1,3,5-trifunctionalized-2,4,6-trialkylbenzene, are of interest in supramolecular chemistry. For the first time,...The content of this RSS Feed (c) The Royal Society of ChemistryDharmveer Bhedi
- Synthesis of 3'-deoxy-4'-thionucleosides June 2, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00725B, PaperYoshihiro Natori, Aya Itoh, Momoko Adachi, Hideaki Wakamatsu, Yukako Saito, Asako Kaise, Yuichi YoshimuraThe racemic synthesis of 3'-deoxy-4'-thionucleosides, which are of interest as potential antiviral and antitumor drug candidates, was achieved. A key reaction involved a tandem intra-and intermolecular S N 2 reaction...The content of this RSS Feed […]Yoshihiro Natori
- Imine bond protection by supramolecular encapsulation June 2, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00736H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bradley D. Smith, Kejia ShiThe imine bond (Schiff base) is ubiquitous in chemistry, biochemistry, and materials science, even though it is susceptible to hydrolysis in aqueous environments. Nature protects reactive imines by […]Bradley D. Smith
- Construction of an aptamer-conjuncted molecular artificial enzyme with enhanced activity and selectivity June 2, 2026Org. Biomol. Chem., 2026, Accepted ManuscriptDOI: 10.1039/D6OB00401F, PaperYanjing Ke, Xindi Li, Wenhui Shi, Yuze Han, Xin Peng, Mengfan WangAlthough molecular artificial enzymes have displayed tremendous potential in many homogeneous reactions, their low catalytic selectivity is still a challenge. In this study, an aptamer strategy was developed to construct...The content of this RSS Feed (c) The […]Yanjing Ke
- 2-Substituted oxazolyl and thiazolyl amino acids are suitable P1 surrogates for new SARS-CoV-2 main protease inhibitors June 1, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00697C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zijie Liu, Tayla J. Van Oers, Conrad Fischer, Anna Nguyen, Johnson Chew, John C. VederasSynthesis of enantiopure heteroazole amino acid building blocks from commercially available materials for incorporation into SARS-CoV-2 Mpro inhibitors as […]Zijie Liu
- NMM-promoted decarboxylative C(sp3)–C(sp3) coupling of coumarin-3-carboxylic acids and indolin-3-ones June 1, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00593D, CommunicationZhan-Yong Wang, Can Zhang, Xiao-Tian Wang, Xiao-Jin Sun, Yi-Lin Wang, Ting Yang, Chenyang Ma, Ran Xia, Hongxin LiuA mild, metal-free cascade via Michael addition/decarboxylation affords biologically relevant indolin-3-one-substituted chroman-2-ones with excellent diastereoselectivity, broad scope, and operational simplicity at room temperature.To cite this article before page numbers are assigned, […]Zhan-Yong Wang
- Anti-adipogenic cyathane diterpenoids from Onychium japonicum May 31, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00575F, PaperZhen-Yu Yang, Wen-Na Fan, Xiu-Qing Song, Yao-Yue FanOnychium japonicum, a Zhuang ethnic medicine, has demonstrated promising anti-obesity potential in preliminary pharmacological studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryZhen-Yu Yang
- Visible-Light-Driven Photocatalyst-Free Synthesis of N-Aryl Amino Acids June 5, 2026
