RSC – Org. Biomol. Chem. latest articles- Electrochemical regioselective reduction of α-keto amide with methanol as hydrogen source April 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00384A, PaperJin Jin Zhang, jinghong wang, Ya Hui Sang, Haijuan Qin, Chao Chen, Wei LiuAn efficient method of α-keto amides to α-hydroxy amides has been developed for the regioselective hydrogenation reduction. Under the assistance of electricity and methanol as both hydrogen source and solvent,...The content of this RSS Feed […]Jin Jin Zhang
- Aromatic layered foldamer based on (cis, cis)-squaramide: Chiral induction and absolute structure April 17, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00324E, PaperKazusa Kuyama, Fumi Takeda, Ayano Ikeda, Kimiko Tanaka, Kosuke Katagiri, Masatoshi Kawahata, Yusuke Okada, Nagao Kobayashi, Hiroyuki Kagechika, Aya TanataniThe meta-linked bissquaramides 8 and 9 were synthesized and spectroscopically characterized. Compound 9 consists of two N,N’-dialkyl-N,N’-diphenylsquaramides 6 sharing a common benzene ring, and, despite the S-chirality of each […]Kazusa Kuyama
- A systematic kinetic assay of phenylsulfonyl pyridine derivatives with free thiol for site-specific modification of proteins April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00450K, PaperXing Zhang, Mo-Han Li, Ben-Guang Chen, Hong-Kai Liu, Xun-Cheng SuSite-specific modification of proteins with functional groups is a powerful way of understanding the dynamics and functions of proteins. Recently reported phenylsulfonyl pyridine is a thiol-specific moiety and is of...The content of this RSS Feed (c) The Royal Society […]Xing Zhang
- Cyclopropanation Reactions by a Class I Unspecific Peroxygenase April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00426H, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiacheng Li, Katy A.S. Cornish, Balazs Pogranyi, Benjamin Melling, Jared Cartwright, William Paul Unsworth, Gideon GroganNon-natural biotransformations, such as alkene cyclopropanation through carbene insertion, have been demonstrated for the hemoproteins cytochrome P450 and […]Jiacheng Li
- Facile DNA chemical ligation under mild conditions enabled by 1-cyano-4-(dimethylamino)pyridinium tetrafluoroborate (CDAP) April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00411J, CommunicationHiroki Yamada, Yasuaki Kimura, Hiroshi Abe, Junichiro YamamotoWe report the chemical ligation of DNA using 1-cyano-4-(dimethylamino)pyridinium tetrafluoroborate (CDAP). CDAP promoted DNA ligation without depurination or undesired side reactions to the nucleobase. Ligation of 3'-phosphate and 5'-hydroxyl termini...The content of this RSS Feed (c) The Royal Society of ChemistryHiroki Yamada
- Photochemical cascade cyclization of quinazolinone-tethered unactivated alkenes with α‐halocarbonyls toward 2,3-fused quinazolinones April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00534E, CommunicationYanhui Gou, Xiaoqing Wang, Juan Wang, Hongya Li, Yunyi Zhang, Zhengsen YuThe divergent synthesis of 2,3-fused quinazolinones via photocatalytic tandem cyclization has been disclosed. It features green reaction conditions, good functional group compatibility and applicable to gram-scale synthesis. Especially the precursors...The content of this RSS Feed (c) The […]Yanhui Gou
- Fluorohydrins and where to find them: recent asymmetric syntheses of β-fluoro alcohols and their derivatives April 16, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00330J, Review ArticleKelly Burchell-Reyes, Jean-François PaquinThe present work provides an overview of synthetic approaches to fluorohydrins and their fluorinated group derivatives that have been explored in the past decade, as well as selected examples of these syntheses applied to medicinal chemistry.To cite this article before page numbers are assigned, […]Kelly Burchell-Reyes
- Synthesis of 2-Acetylnoviosamine by Hydrogenolytic Cleavage of a Spirocyclopropane April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00469A, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maruan David Salim, Isabella Ferrara, Olivier Blacque, Karl GademannPreparation of a 2-acetamido derivative of the rare 5,5-gem-dimethyl-deoxy carbohydrate noviose is reported in this study. The synthesis starts from readily available N-acetyl-d-mannosamine and tackles […]Maruan David Salim
- Claisen rearrangement enabled efficiently access to biaryl phenols April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00468C, CommunicationKe Yu, Tongxiang Cao, Shifa ZhuA rapid method for C2-arylation of hydroxypyranone systems via an reductive iodonio-Claisen rearrangement (RICR) of λ³-iodanes is reported. By integrating the rearrangement products with a tandem Claisen reaction, a series...The content of this RSS Feed (c) The Royal Society of ChemistryKe Yu
- Recent Advances in Electrochemical Utilization of NHPI Esters April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00467E, Review ArticleBhawana Jat, Dinesh Kumar Yadav, Satpal Singh Badsara, Siddharth SharmaElectrochemical methods employing N-hydroxyphthalimide (NHPI) esters have emerged as powerful tools for sustainable organic synthesis. Derived from abundant and stable alkyl carboxylic acids, NHPI esters enable the generation of alkyl...The content of this RSS Feed (c) The Royal […]Bhawana Jat
- Dehydroxyselenocyanation of Alcohols Under Grinding Condition April 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00305A, CommunicationXinzhe Zhao, Hongquan Yin, Fu-Xue ChenA novel strategy for dehydroxyselenocyanation of alcohols, utilizing a readily available electrophilic selenocyanating reagent N-selenocyanatophthalimide in combination with triphenylphosphine under grinding conditions within 2 min at room temperature was developed....The content of this RSS Feed (c) The Royal Society of ChemistryXinzhe Zhao
- Recent Advances in the Synthesis of 3,4-Fused Tricyclic Indoles April 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00202H, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tetsuhiro Nemoto, Shingo Harada, Takahito Kuribara, Shinji HaradaThe 3,4-fused tricyclic indole framework is a key structural motif in numerous bioactive natural products and pharmaceuticals, thus, it has drawn much attention in synthetic […]Tetsuhiro Nemoto
- Asymmetric Synthesis of C–N Axially Chiral Carbazoles via Axial-to-Axial Chirality Transfer April 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00587F, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Myllek, Philip Lencer, Moritz K. T. Klischan, Birgit Henssen, Philipp Neudecker, Martin Breugst, Jörg PietruszkaC–N axially chiral carbazole derivatives were synthesised by an intramolecular Buchwald-Hartwig amination starting from C–C axially chiral biaryls […]Sebastian Myllek
- Convenient One-Step Construction of Fused- or Zwitterionic Indanes from Tetraynes April 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00370A, PaperChencheng Liu, Yao Tong, Fenhua Wang, Qing-Hai LiA straightforward technique for the construction of fused or zwitterionic indanes by a one-pot, cascade hexadehydro-Diels-Alder (HDDA) reaction of different functionalized tetraynes with nucleophilic reagent (vinyl carbazole or DMSO). The...The content of this RSS Feed (c) The Royal Society of ChemistryChencheng Liu
- Unveiling Choline Chloride-Thiourea (1:1) DES as Greener Media and Reagent for Pyrimidinethione Synthesis from α,β-unsaturated carbonyl compounds April 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00182J, PaperApeksha Singhal, Ankit Yadav, Shashwat Vashisht, Khushi Tyagi, T. M. Rangarajan, Sharda PasrichaWidespread studies on developing greener organic chemistry techniques were prompted by growing concerns about the health and environmental issues brought on by the effects of organic compounds. Since solvents and...The content of this RSS Feed (c) […]Apeksha Singhal
- Catalyst-free and oxidant-free cyclocondensation of 2-aminobenzamides with glycosides under visible light April 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00443H, CommunicationJian Wang, Tiancheng Gong, Zirui Zhuang, Bing Sun, Fang-Lin ZhangA mild and eco-friendly approach for the synthesis of quinazolinones was developed. This method enables the cyclocondensation of 2-aminobenzamides with glycosides under visible light without catalysts and oxidants.To cite this article before page numbers are assigned, use the DOI […]Jian Wang
- Red-shifted photoredox generation and trapping of alkyl radicals towards bioorthogonality April 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00476D, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.David Montoto, Uxía Deus-Lorenzo, María Tomás-Gamasa, Jose Luis Mascareñas, Mauro MatoThe photocatalytic generation and trapping of alkyl radicals is a powerful synthetic tool in organic chemistry, but it remains underexplored in bioorthogonal settings. […]David Montoto
- Asymmetric aza-Friedel–Crafts reaction of newly developed ketimines: access to chiral indeno[1,2-b]quinoxaline architectures April 14, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00372E, CommunicationZhen-Hua Wang, Tong Zhang, Dong-Qun Huang, Jia-Xin Li, Yong You, Lei Yang, Jian-Qiang Zhao, Yan-Ping Zhang, Wei-Cheng YuanThe functionalized 11-amino-indeno[1,2-b]quinoxaline motif is crucial for a wide range of bioactive compounds. In this report, A chiral phosphoric acid-catalyzed asymmetric aza-Friedel–Crafts reaction between indeno[1,2-b]quinoxalin-11-imines and indoles was developed. With...The content […]Zhen-Hua Wang
- Configurationally Labile α-Bromoacid Derivatives for Asymmetric Preparation of Heterocycles April 14, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00207A, Review ArticleSumin Lee, Yong Sun Parkα-Bromoacid derivatives are configurationally labile under various conditions, and the dynamic resolution of them has been recognized as an effective strategy in asymmetric synthesis. This article is a concise review...The content of this RSS Feed (c) The Royal Society of ChemistrySumin Lee
- DMSO enhances the biosynthesis of epoxyquinols in Pestalotiopsis sp. (strain IQ-011) and yields new [4 + 2] cycloaddition dimers April 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00115C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Enrique Aguilar-Ramírez, José Rivera-Chávez, Mario Yair Miranda-Rosas, Diego Martínez-OteroDMSO-induced epigenetic modulation of Pestalotiopsis sp. IQ-011, and combined with metabolomic analysis, led to the discovery of four novel metabolites, including three dimeric epoxyquinols generated […]Enrique Aguilar-Ramírez
- Electrochemical regioselective reduction of α-keto amide with methanol as hydrogen source April 17, 2025
