RSC – Org. Biomol. Chem. latest articles- I2‑DMSO-mediated [4+ 2 ] cyclization of methyl ketone with 2-aminobenzimidazole to construct 2,4-disubstituted benzo[4,5]imidazo[1,2-a]pyrimidines April 25, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00314H, PaperQian Guo, Mengyi Guo, Luoteng Cheng, Yifan Song, Wanqian Ma, Yibo Song, Suzhen Li, Xiaoqiong Deng, Xinxin Jia, Jianyong YuanAn efficient synthetic method for constructing 2,4-disubstituted benzo[4,5]imidazo[1,2-a]pyrimidines skeletons through I2-DMSO-mediated and Aldol condensation regioselective [4+2] cyclization is reported. A multicomponent reaction mediated by I2-DMSO using 2-aminobenzimidazole and acetophenone […]Qian Guo
- Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles April 25, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00339C, Review ArticleFatemeh Doraghi, Mohammad Hadi Edareh, mehdi ghanbarlou, Bagher Larijani, Mohammad MahdaviBenzothiazoles are one of the most important heterocycles in pharmaceuticals, natural products, and functional materials. Hence, the development of direct and sustainable routes by replacing hazardous/toxic thiol reagents with nontoxic...The content of this RSS Feed (c) The […]Fatemeh Doraghi
- Water-Compatible Electrogenerated Chemiluminescence Effect Derived from Readily Accessible Tripyridinium Salts April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00417A, PaperLewei Wang, Ru Zhang, Wenrong Cai, Junyao Li, Junming Chen, Datong WuConsidering that numerous studies have shown pyridinium salts can be reduced electrochemically to form cationic radicals, we wonder whether these cationic radicals can further react with co-reactants to create excited-state...The content of this RSS Feed (c) The […]Lewei Wang
- Investigation the influence factors on the selectivity and response time of the glyoxal-selective probe April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00366K, PaperXianshun Zeng, Yuanyuan Wu, Chang Liu, Huirong Yao, Song He, Liancheng ZhaoIn this work, four o-phenylenediamine conjugated fluorescent probes 1-4 with different substituents on the amino group have been designed and prepared for investigation the influence factors including selectivity and response...The content of this RSS Feed (c) The […]Xianshun Zeng
- Enhanced Glucose Regulation Potential of C-peptide Mimics April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00318K, PaperAlpana Boruah, Nazim Uddin Afzal, Sayari Saha, Anusmrita Mazumdar, Dibyajyoti Ozah, Thaneswar Bora, Panchami Prabhakaran, Prasenjit Manna, Arup RoyThe Connecting peptide (C-peptide) once relegated as an epiphenomenon in insulin biosynthesis, has now been recognized for its capacity to instigate molecular effects along with important physiological functions. These findings...The […]Alpana Boruah
- Regulation of chromenylium fluorophore with a built-in recognition site for the detection of sulfite April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00504C, PaperAnqi Hou, Yuanyuan Wu, Yumeng Liu, Chang Liu, Huirong Yao, Xianshun ZengA double charged cationic pyridinium-fused chromenylium analogue DMCQ with an acceptor-π-acceptor (A-π-A) electronic structure was designed and prepared for the sensitive and selective detection of SO32-. Undergoing a Michael addition...The content of this RSS Feed (c) The […]Anqi Hou
- Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00554J, CommunicationJinhui Cai, Chuanquan Chu, Yu Liu, Min Mao, Dahan Wang, Jinbing Liu, Huaixin Wei, Mingming YuA variety of 2,5-disubstituted 1,3,4-thiadiazoles is efficiently synthesized in 28-84% yields via three-component cyclization of 2-methylquinolines, arylhydrazides, and S powder under metal-free conditions which is successfully demonstrated here. This approach...The content of this […]Jinhui Cai
- Deciphering the Mechanism and Stereoselectivity of the [3+2] Cycloaddition Between C-(D-Glucoso)-N-Methyl Nitrone and 1H-Pyrrole-2,5-Dione: A MEDT Investigation April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00529A, PaperMohamed CHELLEGUI, Simplice KOUDJINA, Ines Salhi, Sofiane Benmetir, Raad Nasrullah Salih, Haydar Mohammad-Salim, Guy Y.S. Atohoun, Jesus Vicente de Julián-OrtizIn this study, a molecular electron density theory (MEDT) is used to describe the reaaction mechanism and the experimental stereoselctivity of the [3+2] cycloaddition (32CA) reactions of C-(D-glucoso)-N-methyl nitrone […]Mohamed CHELLEGUI
- A Formal [4+1] Annulation incorporating Styrylogous Aldol Condensation to Access Substituted 2-Styryl-benzofurans April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00348B, CommunicationMANYAM SUBBI REDDY, Kandivalasa Kamala, Surisetti SureshDespite the well-established aldol reaction and its vinylogous variants, the styrylogous version has been scarcely reported. Herein, we have introduced a styrylogous aldol condensation reaction. A novel base-mediated formal [4+1]...The content of this RSS Feed (c) The Royal Society of ChemistryMANYAM SUBBI REDDY
- Visible-light-promoted phosphine-mediated synthesis of thioesters and thioalkynes from sodium arylsulfinates April 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00453E, PaperSen Chen, Yu Yu, Min ChenWe herein report a facile access to thioesters and thioalkynes by the visible-light-promoted phosphine-mediated radical deoxyfunctionalization of sodium arylsulfinates, with activated acids and iodoalkynes respectively. The introduction of acid additives...The content of this RSS Feed (c) The Royal Society of ChemistrySen Chen
- Photoinduced N‑Heterocyclic Nitrenium-Catalyzed Single Electron Reduction of α-Chloro Esters for Phenanthridine Synthesis April 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00530B, CommunicationLing Zhou, Xiao-Xue Pei, Wei Gong, He Sheng, Zhusheng YangVisible-light photoredox catalysis has revolutionized synthetic methodologies by enabling sustainable radical-mediated transformations under mild conditions. Herein, we report a catalytic protocol employing N-heterocyclic nitrenium (NHN) iodide salts to drive the...The content of this RSS Feed (c) The Royal Society […]Ling Zhou
- Efficient thiol-ene click reactions of acryloyl-derivatized carbohydrates on mammalian cell surfaces April 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00373C, CommunicationYasuhiko Iwasaki, Yuto Tabe, Ryosuke Tanaka, Yota OkunoWe present a method for noninvasive surface engineering of mammalian cells using thiol-ene click reactions with acryloyl-derivatized carbohydrates. This optimized process allows rapid and efficient light-assisted ligation of thiol-bearing molecules...The content of this RSS Feed (c) The Royal Society of ChemistryYasuhiko Iwasaki
- Electrophilic fluorination of cannabinol (CBN) April 23, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00378D, Communication Urvashi, Melvin Druelinger, John Hatfield, Kenneth J. OlejarSeveral fluorinated cannabinol compounds (3a–g) were synthesised via an electrophilic fluorination process.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryUrvashi
- Concise organocatalyzed epoxidation based total synthesis of (−)- and (+)-trans-posticlures and (−)-(6Z,9Z,4S,5S)-trans-4,5-epoxynonadeca-6,9-diene April 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00597C, PaperRodney Agustinho Fernandes, Gulenur N. KhatunA concise, flexible and efficient organocatalytic strategy has been developed for the enantioselective synthesis of (−)-trans- and (+)-trans-posticlures, along with (−)-(6Z,9Z,4S,5S)-trans-4,5-epoxynonadeca-6,9-diene which are remarkable natural trans-epoxide pheromones. The key transformations...The content of this RSS Feed (c) The Royal Society of ChemistryRodney Agustinho Fernandes
- Constructing chiral bicyclo[3.2.1]octanes via low-loading organocatalysis April 23, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00203F, PaperEtikala Ashok, Pandhiti R. Lakshmi, Revoju Sravanthi, Dhevalapally B. RamacharyMulti-centric ambident 2-hydroxy-3,5-dialkyl-p-quinones selectively reacted with α-alkylnitroethylenes under the low-loading of (1.0 mol% to 500 ppm) Rawal’s quinine-squaramide-catalyst followed by in situ acid-catalysed tert-hydroxy group acetylation constructed the high-yielding chiral...The content of this RSS Feed (c) The Royal Society […]Etikala Ashok
- A synthetic investigation into the biosynthesis of hypsampsone A April 22, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00045A, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jhayden J. A. Jarman, Andreas B. zur Bonsen, Jonathan H. GeorgeA sequence of an intramolecular carbonyl–ene reaction, an α-hydroxy-β-diketone rearrangement and an intramolecular aldol reaction is suggested to explain the biosynthesis of hypsampsone A, […]Jhayden J. A. Jarman
- Pd-Catalyzed Efficient Synthesis of 3-Formylindole Derivatives with Diaziridinone April 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00246J, PaperJianjun Wang, E Yang, Wei Liu, Shiwei Zhang, Yian ShiThis work describes an efficient Pd-catalyzed annulation process of acetal alkynes, aryl iodides, and di-t-butyl diaziridinone to afford a variety of 3-formylindoles and their derivatives. The reaction likely proceeds through...The content of this RSS Feed (c) The Royal Society […]Jianjun Wang
- Hydrogen-Bonding-Controlled Stereospecific Synthesis of Z-Enamides April 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00333D, CommunicationXiaoyu Zhang, Xiangyu Lu, Yajun Zou, Jia-Jia Lang, Gang Zhao, Ying-Wei WangIn this study, a series of Z-enamide compounds were synthesized from α-amino ketones and alkynyl esters. Using triethylamine as the base catalyst, the reaction proceeded smoothly at room tem-perature to...The content of this RSS Feed (c) The […]Xiaoyu Zhang
- Novel indolespiro bicoumarins: synthesis and their antifungal activity April 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00448A, PaperZhengyu Liu, Qihe Liu, Li Chen, Yukang Liu, Ting Zhao, Liuqing Yang, Min Zhang, Changsheng YaoThis article reports a spiro cyclic system that contains an oxoindole and two coumarin rings. Dozens of compounds with such structure have been synthesized via a facile three-component reaction of...The content of this […]Zhengyu Liu
- Electrooxidative synthesis of 1,2,3-triazolone 1-amines April 22, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00481K, PaperKseniia Yu. Titenkova, Daniil Chaplygin, Leonid L. FershtatA new method for the synthesis of newly reported heterocycles, namely 1,2,3-triazolone 1-amines, via electrochemically induced intramolecular N-N bond formation was performed. The process involves electrooxidative cyclization of the readily...The content of this RSS Feed (c) The Royal Society of ChemistryKseniia Yu. Titenkova
- I2‑DMSO-mediated [4+ 2 ] cyclization of methyl ketone with 2-aminobenzimidazole to construct 2,4-disubstituted benzo[4,5]imidazo[1,2-a]pyrimidines April 25, 2025
