RSC – Org. Biomol. Chem. latest articles- Photoactive chiral structures for light driven enantioselective carbon-carbon bond forming reactions April 14, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00420B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vijay Kumar S, A. Hameed Ibrahim, Anjan DasThe asymmetric photocatalysis has appeared as a powerful strategy for forming enantioselective carbon-carbon bonds under mild conditions with high levels of enantioselectivity. Within this area, […]Vijay Kumar S
- Room-Temperature Metal-Free Oxidative Alkoxylation/Amidation of Benzofuran-3(2H)-ones with Simple Alcohols and Nitriles April 14, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00357E, CommunicationYuting Bao, Kexin Zhou, Shenshen Xu, Qianqian Yi, Min Wang, Yuhao Chen, Yuepiao Cai, Qinqin XiaMetal-free oxidative alkoxylation/amidation of benzofuran-3(2H)-ones with alcohols and nitriles is disclosed, which enables the synthesis of a broad range of 2-monosubstituted benzofuran-3(2H)-ones in moderate to excellent yields under mild conditions....The content of this […]Yuting Bao
- First total synthesis and evaluation of the α-glucosidase inhibitory activity of (±)-methyl dihydromarmesinate, an anti-inflammatory phenylpropanoid from Ficushirta Vahl., and related benzofurans April 14, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00365F, PaperPaula K K Paz Armero, NATALIA L. CALVO, Mario Oscar Salazar, R Furlan, Teodoro S Kaufman, Andrea B.J. BraccaThe first total synthesis of (±)-methyl dihydromarmesinate (6 steps, 52% yield), an anti-inflammatory phenylpropanoid from the hairy fig, is reported from 2,4-dihydroxybenzaldehyde. The concise reaction sequence involved minimal use of...The […]Paula K K Paz Armero
- Visible-Light-Induced Oxidant-Free Thiol–Disulfide Transformation April 13, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00450D, CommunicationJunhui Wang, Dan-Dan Fan, Zhijie Li, Junhui Tian, Jie Sun, Jian Wang, Jiang-Kai Qiu, Canliang Ma, Kai GuoDisulfides are of great value in various fields, including natural products, proteins, pharmaceutical molecules, and materials science. However, conventional synthesis methods typically rely on transition metal catalysts and require the...The content […]Junhui Wang
- Synthesis, molecular modeling and anti-inflammatory activity of new benzo[a]pyrano[2,3-c]phenazine compounds April 13, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00411C, PaperQuynh Giang Nguyen Thi, Tuan Anh Nguyen, Ha Thanh Nguyen, Hai Pham‑The, Hoang Thi Phuong, Thach Lien Nguyen, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Mai T. Dang, Thu Ha Nguyen Thi, Julien Braire, Tuyen Van NguyenA convenient microwave-assisted three-component synthetic approach was developed for the synthesis of new […]Quynh Giang Nguyen Thi
- Macrocyclic Peptides as Protein-Protein Interaction Modulators: A Review April 13, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00106H, Review ArticleErin Ann Sunny Sunny, Sandhya SadanandanProtein-protein interactions (PPIs) are essential for cellular function, mediating processes such as signal transduction, enzymatic catalysis, and the formation of macromolecular complexes. PPIs are crucial for targeting therapeutics, as disruptions...The content of this RSS Feed (c) The Royal Society of ChemistryErin Ann Sunny Sunny
- Construction of 2H-1,4-selenazin-3(4H)-one framework via cyclization of pyrazole derivatives bearing chloroacetamide and selenocyanate fragments April 13, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00263C, PaperTatiana A Kudryavtseva, Ekaterina Kudryavtseva, Boris V. LichitskyFor the first time, we developed an efficient three-step method for the synthesis of substituted 1,7-dihydropyrazolo[4,3-b][1,4]selenazin-6(5H)-ones starting from readily accessible 5-aminopyrazoles. The presented approach is based on preliminary preparation of...The content of this RSS Feed (c) The Royal Society of ChemistryTatiana A Kudryavtseva
- Pentaphosphorylated Magic Spot Nucleotides: Chemoenzymatic Synthesis and Disassembly-Based Sensing April 13, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00328A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patrick Moser, Subhra K Roy, Marvin Herzog, Felix Bauer, Felix Wollensack, Bernhard Breit, Henning Jacob JessenThe magic spot nucleotides (MSNs), (p)ppGpp and (p)ppApp, play central roles in bacterial stress signaling, yet their selective […]Patrick Moser
- Synthesis of optically active cyclopropanes by functionalization of cyclopropenes April 12, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00312E, Review ArticleTomohiro Yasukawa, Janine CossyOptically active cyclopropanes are accessed by reduction and functionalization of racemic cyclopropenes via enantioselective catalysis or by diastereoselective transformations of optically active cyclopropenes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Tomohiro Yasukawa
- Synthesis and properties of nonaromatic stable N-methylated triphyrin(2.1.1)s April 9, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00349D, PaperAkrti Sharma, Mangalampalli RavikanthN-Methylation of 14π aromatic triphyrin(2.1.1)s with CH3I in THF at 60 °C affords stable nonaromatic N-methylated derivatives via meso-sp2 to sp3 conversion. These show stronger visible-NIR absorption and are more electron-rich than aromatic analogues.To cite this article before page numbers are assigned, use the DOI […]Akrti Sharma
- Electrochemical Synthesis of Cyanated Imidazo[1,5-a]pyridines April 9, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00336B, PaperHao Yang, Kai Li, Yupu Zhang, Qi Sun, Zhiyong WangAn electrochemical cyanidation reaction was developed in the presence of iodine under metal-free and chemical-oxidantfree conditions. Using this synthetic method, a novel class of cyano-functionalized imidazopyridine N-heterocycles was prepared smoothly...The content of this RSS Feed (c) The Royal Society […]Hao Yang
- A convenient synthesis of 2,4-diarylpyrroles from β-cyanoketones via reductive rearrangement of in situ generated 2-aminofurans April 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00423G, PaperDmitrii A. Aksenov, Tatyana S. Galushko, Daniil S. Garkusha, Maria S. Volosovtsova, Nicolai A. Aksenov, Nikolai A. Arutiunov, Daria I. Murashkina, Alexander V. AksenovA new, efficient, and regioselective method for the synthesis of 2,4-diarylpyrroles starting from readily available aryl-substituted β-cyanoketones has been described.To cite this article before page […]Dmitrii A. Aksenov
- Substituent effects direct anion transport in aryl-triazole derivatives April 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00449K, CommunicationJuejiao Fan, Wei Wu, Xinyi Dou, Jiakai Huo, Xu Tang, Songze Li, Chunyan BaoA series of aryl triazole compounds were designed as synthetic chloride carriers, with their activity enhanced by strong electron-withdrawing substituents through facilitating chloride binding, transmembrane diffusion, and release.To cite this article before page numbers are […]Juejiao Fan
- Cyclooctadiene-derived cage-divergent synthesis of heteroadamantanes and alternative polycyclic systems April 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00368K, CommunicationVladyslav Lysenko, Ioann O. Popov, Evgeniy Y. Slobodyanyuk, Eduard B. Rusanov, Olexandr Ye. Pashenko, Dmytro M. Volochnyuk, Serhiy V. RyabukhinStarting from cycloocta-1,5-diene, scalable protocols provide oxygen- and nitrogen-doped adamantane analogues and novel spherical morpholine mimetics. The route uses inexpensive reagents and supports multigram to multi-hundred-gram preparation.To cite this […]Vladyslav Lysenko
- Visible light-induced synthesis of benzofuro[3,2-b]pyridines from aurone-derived azadienes April 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00444J, CommunicationJiale Fan, Jianwei Xie, Pinxg Lu, Yanguang WangThe visible light-induced regioselective synthesis of benzofuro[3,2-b]pyridines from aurone-derived azadienes is achieved through a radical dimerization/aromatization mechanism under catalyst-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Jiale Fan
- tert-Butyl hydroperoxide mediated Wacker-type oxidations: taking advantage of hexafluoro-2-propanol for challenging substrates April 8, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01683E, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Calum Maguire, Qun Cao, Selena C. L. Gilmer, Bill C. Hawkins, Peter C. Knipe, Mark J. MuldoonHFIP improves Pd-catalysed Wacker-type oxidation reactions using TBHP as the oxidant. The method was applied to a […]Calum Maguire
- Dual Strategy Approach for an Aliphatic Nitrile Directing Group Assisted Palladium-Catalyzed meta-C–H Arylation/Acetoxylation of Arenes April 8, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00415F, CommunicationRaut Kaustubh, Dasari Srinivas, Ch Subrahamayam, Satyanarayana GeduThe meta-selective arylation of simple aliphatic nitirile-bearing arylmethanesulfonic acid derivatives under microwave-accelerated conditions has been developed. Also presents the meta-arylation of 3-phenylpropanoic acid esters tethered to a nitrile template under...The content of this RSS Feed (c) The Royal Society of ChemistryRaut Kaustubh
- Deoxygenation of carboxylic acids-based radical-polar crossover process for modular access to functionalized cyclopropanes April 8, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00409A, CommunicationHaiyan Ding, Yan Li, Li Zhang, Yewen FangHerein, a photoredox-catalyzed strategy has been successfully developed for the preparation of arylformylmethyl cyclopropanes via acylative coupling of (hetero)aryl carboxylic acids with homoallyl tosylates. This deoxygenation-based radical-polar crossover process was...The content of this RSS Feed (c) The Royal Society of ChemistryHaiyan Ding
- Metal-free electrochemical decarboxylative cyclization of N-aryl glycines with azobenzenes April 7, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00350H, PaperWenji Zhu, Xuyuan He, Yujun Gao, Mengqi Liu, Jincheng Ye, Shulin NingA highly regioselective decarboxylative cyclization strategy of N-aryl glycines with azobenzenes under mild electrochemical conditions is introduced, which could provide direct access to a diverse set of 1,2,4-triazolidines.To cite this article before page numbers are assigned, use […]Wenji Zhu
- Access to arylurazoles bearing both central and C–N axial chirality via asymmetric desymmetrization catalyzed by chiral phosphoric acid April 7, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00223D, CommunicationWenhui Wu, Wenkai Li, Yongqiang Xu, Yuhan Zhou, Jingping Qu, Baomin WangA chiral phosphoric acid-catalyzed desymmetrization of N-aryl urazoles with pyrazolones is reported, enabling simultaneous construction of central and C–N axial chirality to afford the atropisomer with high stereocontrol.To cite this article before page numbers are assigned, use […]Wenhui Wu
- Photoactive chiral structures for light driven enantioselective carbon-carbon bond forming reactions April 14, 2026
