RSC – Org. Chem. Front. latest articles- Enantioselective polar [2σ + 2π] cycloadditions of bicyclo[1.1.0]butanes and ortho-quinone methides enabled by chiral phosphoric acid catalysis November 1, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01029B, Research ArticleLun Xu, Qingwei Zhong, Yalan Zhou, Runqin Liu, Xian Sun, Xiao-Yu Liu, Yong Qin, Hao SongHerein, we report a chiral phosphoric acid-catalyzed enantioselective synthesis of spiro-bicyclo[2.1.1]hexanes featuring vicinal tertiary-quaternary stereocenters. This method employs a formal [2σ + 2π] cycloaddition between bicyclo[1.1.0]butanes and ortho-quinone methides under...The content of […]Lun Xu
- Recent advances in light-enabled deoxygenative transformation of alcohols November 1, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01215E, Review ArticleShiwei Lü, Jie Ding, Zhenda TanAlcohols, serving as fundamental building blocks in organic synthesis, face inherent challenges in deoxygenative functionalization due to the strong chemical inertness of C-O bond characterized by high bond dissociation energy.Recent...The content of this RSS Feed (c) The Royal Society of ChemistryShiwei Lü
- Investigations of Palladium Catalysed 1,1-Aminoacyloxylation of Unsaturated Carboxylic Acids via Experiments and Machine Learning November 1, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01214G, Research ArticleXiangwen Tan, Yinwu Li, Jiahao Wu, Wanqing Wu, Zhuofeng Ke, Huanfeng JiangPalladium catalyzed aza-Wacker oxidation is one of the most effective ways to construct heterocycles. The understanding of the mechanism underlying these approaches facilitate the development of new efficient and practical...The content of this RSS Feed (c) […]Xiangwen Tan
- Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with (hetero)cyclic iodonium ylides to access pyrano[4,3-b]pyridin-5one derivatives October 31, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01370D, Research ArticleHailang Cui, Shijin Zhou, Borong Su, Bin Yang, Shaoyu Mai, Huaming TaoWe herein report a Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with iodonium ylides, enabling efficient access to medicinally valuable pyrano [4,3-b]pyridin-5-one derivatives. This external oxidant-free approach demonstrates broad...The content of this RSS Feed (c) […]Hailang Cui
- Lewis Acid Catalyzed Tandem Difunctionalization/Fragmentation Reactions of Bicyclobutanes: Access to 2-Vinylidenyl 1,4-Dicarbonyl Compounds October 31, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01031D, Research ArticleKun Deng, Xue-Chun Yang, Jian-Jun Feng, Zhaofeng WangStrain-release-driven transformations of bicyclo[1.1.0]butanes (BCBs) have emerged as a highly effective strategy for generating chemical complexity under mild reaction conditions. Herein, we report a tandem ring-opening reaction of acyl BCBs...The content of this RSS Feed (c) The Royal Society of […]Kun Deng
- Photo-catalyzed Bis-disulfidation of Vinyl Arenes with Tetrasulfides in Aqueous Phase October 30, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01389E, Research ArticleYingming Song, Binbin Huang, Yao Xiao, Zi-Shan Liu, Chen Zhang, Hua Cao, Yue YuIn this study, we developed a green and efficient strategy that photo-catalyzed bis-disulfidation of vinyl arenes in aqueous phase. This method featured mild conditions, achieving the simultaneous and efficient construction...The content of this RSS […]Yingming Song
- Novel antimicrobial self-assembled cyclic peptide nanotubes containing (1R,3S,4R,5R)-3-amino-4,5-dihydroxycyclohexane-1-carboxylic acid, a new building block for developing mimetics of saccharide-peptide hybrids October 30, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01374G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eva González Freire, Marcos Vilela-Picos, Antonio Javier Estevez, Rafael Seoane, Manuel Amorín, Verónica Prado, Concepcion Gonzalez-Bello, Juan R GranjaA new class of supramolecular antimicrobials based on D,L-cyclic peptides containing a dihydroxylated-γ-residue, which […]Eva González Freire
- Enantioselective synthesis of aziridine-fused polycyclic archi-tectures via catalytic asymmetric aza-darzens reaction and reductive cyclization October 30, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01362C, Research ArticleZi-Yi Xie, Cong-Lun Xu, Yu Zhu, Jian-Peng Tai, Yang Liu, Hao-Ting Duan, Yi-Jie Jing, Chao-Nan Chen, Chongqing Pan, Jun XuanAziridine-fused polycyclic architecture is prevalent in biological and natural molecules, but the asymmetric synthesis of such strained frameworks with multiple chiral centers is highly challenging and has not […]Zi-Yi Xie
- [2.2]Paracyclophane–Dicyanorhodanine Conjugates as Planar Chiral Molecular Photoswitches October 28, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01401H, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Parag Das, Cole D Stearns, Ion Ghiviriga, Lukasz Dobrzycki, Ronald K Castellano(Chir)optical molecular photoswitches have garnered significant attention for their applications in asymmetric synthesis, supramolecular chemistry, and the materials sciences. The planar […]Parag Das
- Cobalt-catalyzed cross-electrophile coupling of aryl bromides and linear secondary alkyl bromides October 23, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01310K, Research ArticleRuobin Wang, Qiang Hu, Jun ZhuAn efficient cobalt-catalyzed cross-electrophile coupling (XEC) reaction of aryl halides with linear secondary alkyl halides to construct C(sp3)–C(aryl) motif was reported. The key to the reaction is the use of a phosphino-oxazoline (PHOX) ligand.To cite this article before page numbers are assigned, […]Ruobin Wang
- Bis-Guanidinate Magnesium Amide-Catalyzed Hydroboration of Nitriles and Isocyanides via a Non-Hydride Pathway October 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01184A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sayantan Mukhopadhyay, Smrutirani Padhan, Anubhab Das, Sharanappa NembennaThe bis-guanidinate amido magnesium (II) compound [LMgN(SiMe3)2; L = {(ArHN)(ArN)-C=N−C=(NAr)(NHAr); Ar = 2,6-Et2-C6H3] (Mg-1) has been employed as a pre-catalyst for the dihydroboration of nitriles, […]Sayantan Mukhopadhyay
- cis-Diphosphine Ethene Ligands Enable Ni-Catalyzed Amination of Aryl Chlorides October 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01105A, Research ArticleGuizhi Zhai, Xulu Lv, Xiaoli Li, Yalong Li, Xiaofen Wang, Fengqian Zhao, Junliang WuA class of cis-diphosphine ethene ligands has been designed for the Ni-catalyzed C-N coupling reaction of aryl chlorides. Rigid structure, large steric hindrance and easily adjustable electronic effects are the...The content of this RSS […]Guizhi Zhai
- Transition Metal-Free Transfer of Iodoarenes by Organohypervalent Iodine Compounds. October 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01262G, Review ArticleIshita Neogi, Simi Achankunju, Gourab Mohanty, Keshaba Nanda ParidaIodoarenes are important precursors used for the synthesis of compounds with C-C and C-heteroatom bonds; and are accessed either by arene iodination or by multistep functional group transformations, for instance,...The content of this RSS Feed (c) The Royal Society […]Ishita Neogi
- Photoredox-catalyzed three-component radical coupling of potassium alkyltrifluoroborates, DABSO and polyfluoroarenes October 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01163A, Research ArticleYunliang Guo, Jiuli Xia, Kaixuan Chen, Kehan Jiao, Ying Dong, Guangfan Zheng, Jiao Qu, Jiaqiong Sun, Tao Xiong, Qian ZhangVisible light-driven three-component coupling of RBF4K, DABSO, and polyfluoroarenes through radical–polar crossover mechanisms provides a modular platform for synthesis of polyfluoroarylsulfones.To cite this article before page numbers are […]Yunliang Guo
- Regioselective α-alkylation of benzo-fused cyclic amines via organic photoredox catalysis October 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01322D, Research ArticleZiwei Xia, Richang Wen, Chuang Lei, Lelin Zhou, Fuhong Xiao, Jinhui Cai, Guo-Jun Deng, Ya ChenAn organophotoredox catalytic method has been developed for the selective α-alkylation of benzo-fused cyclic amines with alkenes.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Ziwei Xia
- Molecular editing of 3-hydroxyphenyl oxindole derivatives via formal O-insertion and N-insertion: synthesis of dioxolane spirooxindoles and quinoxalin-2(1H)-ones October 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01334H, Research ArticleYao-Bin Shen, Jia-Wei Li, Peng Wang, Houchen Wang, Tiesheng Shi, Fangzhi Hu, Shuai-Shuai LiMolecular editing of 3-hydroxyphenyl oxindole derivatives via formal O-insertion and N-insertion has been developed for synthesis of dioxolane spirooxindoles and quinoxalin-2(1H)-ones.To cite this article before page numbers are assigned, use the DOI form of […]Yao-Bin Shen
- Synthesis of chiral spiro-heterocyclic azides via asymmetric [4 + 2]-cycloaddition of conjugated vinyl azides October 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01290B, Research ArticleYican Lu, Yinhe Qu, Bingqian Yang, Hailong Zhang, Weidi Cao, Xiaoming FengSynthesis of chiral spiro-heterocyclic azides via asymmetric [4 + 2]-cycloaddition of conjugated vinyl azides with aurones and (E)-alkenyloxindoles mediated by chiral N,N′-dioxide/metal complexes.To cite this article before page numbers are assigned, use the DOI form of […]Yican Lu
- Nickel-catalyzed C(sp2)–H bond aminoalkylation of alkenes and arenes for the synthesis of δ-amino acid derivatives October 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01273B, Research ArticleJie-Sheng Tian, Rui-Qi Li, Duan-Yang Liu, Jie Tan, Yong-Xin Yang, Teck-Peng LohEfficient Ni-catalyzed C(sp2)-H aminoalkylation enables chiral amine synthesis with facile operation, accessible building blocks, and retained stereochemistry, advancing drug late-stage diversification.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Jie-Sheng Tian
- Pd-catalysed flow Tsuji–Trost allylation of phenols: continuous-flow, extraction-free synthesis of esmolol via allylation, epoxidation, and aminolysis October 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01336D, Research ArticleKwihwan Kobayashi, Maiko Yamashita, Takenori Kimura, Yoshihiro Kon, Takuya Nakashima, Shun-ya Onozawa, Shū KobayashiA Tsuji–Trost allylation for phenols using a heterogeneous Pd catalyst and allyl methyl carbonate, eliminating the need for halide-based reagents and bases, is reported. Through the integrated continuous-flow process, esmolol can be synthesized.To cite […]Kwihwan Kobayashi
- Visible Light Induced Cross-Dehydrogenative Coupling of N-Heterocyclic Compounds: Green and Efficient Synthetic Strategies October 20, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01346A, Review ArticleDivyani P. Patel, Vishwa K. Patel, Satish Kumar SinghCross-dehydrogenative coupling (CDC), which directly modifies C–H bonds, is a powerful tool in modern organic synthesis. It saves atoms and steps while making it easier to obtain a wide variety...The content of this RSS Feed (c) The Royal Society […]Divyani P. Patel
- Enantioselective polar [2σ + 2π] cycloadditions of bicyclo[1.1.0]butanes and ortho-quinone methides enabled by chiral phosphoric acid catalysis November 1, 2025
