RSC – Org. Chem. Front. latest articles- Divergent Synthesis of Planar/Central-Chiral [n]Metacyclophanes by Asymmetric Acylation March 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00146G, Research ArticleZiyang Wang, Tingting Du, Haisong Xu, Yidan Sun, Xin LiAcquisition of a single enantiomeric configuration for planar-chiral [n]metacyclophanes, has persistently posed a formidable challenge. Herein, we report the stereodivergent synthesis of planar/central-chiral [n]metacyclophanes through chiral phosphoric acid-catalyzed reactions of...The content of this RSS Feed (c) The Royal […]Ziyang Wang
- Carbon dioxide as a methylene donor: modular synthesis of 3-aminomethyl chromones via a reductive tandem reaction † March 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00205F, Research ArticleYubing Zhou, Zhongrong Xu, Wei Li, Yimei Zeng, Wenxin Jiang, Jie-Ping Wan, Huanfeng Jiang, Chaorong QiA reductive tandem protocol that harnesses CO₂ as a methylene source is reported, enabling direct and modular assembly of biologically relevant 3-aminomethyl chromones from simple o-hydroxyaryl enaminones and amines. The...The content of […]Yubing Zhou
- Visible-Light-Driven Radical Cascade Cyclization of 4-(N-Alkyl-Nacrylamido)coumarins: Access to Difluoroalkylated 4,5-Fused Coumarins and Coumarin[4,3-b]pyridinones March 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00192K, Research ArticleJin-Wei Yuan, Shi-Long Zhang, Xin-Ya Wang, Meng Yan, Yong-Mei Xiao, Donghui Wei, Lingbo QuAn efficient and practical visible-light-driven cascade difluoroalkylation/cyclization of 4-(N-alkyl-N-acrylamido)coumarins has been developed using readily accessible bromodifluoromethylphosphonium bromide ([Ph3PCF2H]+Br-) as a difluoromethyl radical precursor. This protocol enables the rapid construction of...The content of this RSS […]Jin-Wei Yuan
- Efficient Access to 5-Acylated Benzoxasilepines Enabled by NHC/Pd Cooperative Catalysis March 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00100A, Research ArticleLala Wang, Jixing Li, Ziye Cheng, Tingting Li, Huimin Xia, Shi-Chao RenThe termination of the endo-selective cyclization of 2-vinylphenol-derived iodomethylsilyl ether has been limited to hydrogen atom abstraction or transition metal-induced β-hydride elimination, affording non-substituted benzoxasilepines. Herein, we report the efficient...The content of this RSS Feed (c) […]Lala Wang
- DFT and Machine Learning Insights into Ru(II) Complex-Catalyzed Transfer Hydrogenation March 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00178E, Research ArticleGui-Xiang Zhou, Cheng HouTransfer hydrogenation (TH), as a mild reduction strategy that avoids the use of high-pressure molecular hydrogen, has attracted significant interest for the selective reduction of carbonyl compounds. In this study,...The content of this RSS Feed (c) The Royal Society of ChemistryGui-Xiang Zhou
- Computational and synthetic studies on the conversion of isothiocyanates into isocyanides: inspirations from the Corey–Winter olefination March 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00120C, Research ArticleDominik Bauer, Jonas Kaffenberger, Michael Reggelin, Stefan ImmelInspired by theoretical studies of the Corey–Winter-olefination, the Corey–Hopkins reagent has been found to be a very effective means to desulfurize isothiocyanates to isocyanides featuring excellent functional group tolerance.To cite this article before page numbers are assigned, use the DOI […]Dominik Bauer
- Correction: Interactions beyond H-bonding: unveiling the role of unorthodox noncovalent interactions in charged thiourea and its catalytic efficiency March 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO90023B, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Prabhahar Murugan, Parul Rathour, Dipankar Das, Brijesh Patel, Srinu Tothadi, Bishwajit Ganguly, Saravanan SubramanianTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Prabhahar Murugan
- Origin of Enantioselectivity in Copper-Catalyzed Aziridination of Enol Silyl Ethers: A Comprehensive DFT Study March 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00231E, Research ArticleJia-Long Wu, Yuchen Yang, Sheng-Ye Zhang, Xu Liu, Teng Sun, Yanan Zhao, Lijia WangChiral 1,2-amino alcohols are indispensable structural motifs in organic synthesis and pharmaceutical development, with the synthesis of chiral aziridine intermediates being a crucial step. Although experimental data indicate that the...The content of this RSS […]Jia-Long Wu
- Lewis Base/Alkali Metal Halide Co-catalyzed Allylic Alkylation of gem-Diborylalkanes with MBH Carbonates for the Construction of tert-Alkylboronic Esters March 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00181E, Research ArticleZhen-Xu Yang, Bing-Xia Yan, Lei Shi, Lidong Gong, Zhi-Shi YeA mild and efficient DMAP/KF co-catalyzed allylic alkylation of gem-diborylalkanes with MBH carbonates has been developed, providing a series of tertiary alkylboronate esters in moderate to excellent yields. Moreover, this...The content of this RSS Feed (c) The Royal […]Zhen-Xu Yang
- Isothiourea-catalyzed acylation of paracyclophanols for the construction of planar chirality: the mechanism and origin of stereoselectivity March 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00184J, Research ArticleHaowen Chen, Lan Yu, Donghui WeiThis study used DFT to investigate the mechanism and stereoselectivity origin of isothiourea-catalyzed acylation of planar chiral paracyclophanols with isobutyric anhydride via the projection of orbital coefficient vector (POCV) method.To cite this article before page numbers are assigned, use the DOI form […]Haowen Chen
- An expedient modeling construction of the BCDEF pentacyclic ring system analog of aconitine and racemulosine March 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00212A, Research ArticleSuyan Cao, Hailian Li, Jie Zhao, Yuxuan Tang, Liang XuIn this study, we report an expedient strategy for the construction of a highly bridged model pentacyclic framework resembling the BCDEF ring system of aconitine and racemulosine. Key transformations include...The content of this RSS Feed (c) The Royal […]Suyan Cao
- Green synthesis of a 4-hydroxydithiocoumarin-imidazole bis-heterocycle scaffold, and its antiproliferative study and unusual single-crystal XRD pattern March 24, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00082G, Research ArticleAhmad Ali, Nur Amin, Sikhamoni Begam, Pijush Kanti Khanra, Siddhartha Sankar Ghosh, Abu Taleb KhanCatalyst-free synthesis of novel tetra-substituted imidazole-bound bis-heterocycles via a pseudo-five-component reaction. Using 4-hydroxydithiocoumarin, isocyanide, ammonium acetate, and aryl aldehydes forms multiple C–C and C–N bonds in one step.To cite this article before page […]Ahmad Ali
- Enantioselective BIMP-catalysed [2,3]-Wittig Rearrangements of Oxindole-Derived Allylic and Propargylic Ethers March 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00342G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Órla Conboy, Justin O’Yang, Kevin Kasten, David Bradford Cordes, Aidan P. McKay, Tengfei Kang, Andrew D. SmithThe organocatalytic enantioselective [2,3]-Wittig rearrangement of a range of oxindole-derived allylic and propargylic ethers using bifunctional […]Órla Conboy
- Correction: Cu(I)-catalyzed 1,2-carbofluorination of unactivated alkenes enabled by N-fluorobenzamides via free radical relay March 23, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO90022D, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hong Ji, Haifeng Qiao, Boyi Wang, Tianyu Lu, Weixing Chang, Lingyan Liu, Jing LiTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Hong Ji
- Deciphering Light-Triggered Mg2+-Assisted FeCl3 Ion-Pairing: An Efficient Photo-Oxidant for Chemo-Divergent Functionalization of 3-Arylidene Indoline March 21, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01738F, Research ArticleUmasish Jana, Gopal Rana, Maynak Pal, Abhishek Kar, Rajkamal SahooIron-based photocatalysis has emerged as an appealing “green alternative” to precious-metal photocatalysts that rely on ligand-to-metal charge-transfer (LMCT) activation, facilitating advanced organic transformations. Here, we investigate Mg2+-assisted photocatalytic behaviour of...The content of this RSS Feed (c) The Royal […]Umasish Jana
- Hydrogen atom transfer enabled acylsugar synthesis via cooperative copper and NHC catalysis March 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00128A, Research ArticleYuqiong Tan, Yu Xiang, Yang YeIn this study, we report a direct acylation method for saccharides, achieved through the combination of copper and N-heterocyclic carbene (NHC) catalysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Yuqiong Tan
- Photocatalytic coupling of phenols with imines via polarity reversal March 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00103C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cindy R. Liu, Christopher A. Sojdak, Marisa C. KozlowskiA polarity-reversed coupling of phenols with imines is reported by means of photocatalytic conditions.To cite this article before page numbers are assigned, use the […]Cindy R. Liu
- Anion/ion pair binding and chiral modulation investigation based on an 18-crown-6-functionalized Schiff base macrocyclic receptor March 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00203J, Research ArticleChanni Cheng, Shoucheng Sun, Dezhi Zhao, Chengyou Han, Feng WangA novel macrocycle with two 18-crown-6 moieties was synthesized. It exhibits anion recognition and ion pair binding-enhanced complexation and can modulate the CD and CPL absorption properties of chiral phosphate anions via host–guest interactions.To cite this article before […]Channi Cheng
- Visible-light-driven dehalogenative oximation of alkyl halides March 20, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00020G, Research ArticleFeng Xu, Dayong Shi, Ruihua LiuThis study develops a visible-light-driven dehalogenative oximation of alkyl halides via boryl radical-mediated halogen atom transfer, yielding diverse oximes under mild conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Feng Xu
- A mono-meso-free N-confused hexaphyrin with tunable NIR absorption: synthesis, coordination, and oxidative dimerization March 20, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00221H, Research ArticleLingfang Zhang, Zhengpeng Huang, Qizhao Li, Glib Baryshnikov, Bin Zhu, Mingbo Zhou, Chengjie Li, Hans Ågren, Shijun Li, Jianxin Song, Yongshu XieOxidation and Cu(II) metallation of a mono-meso-free N-confused hexaphyrin afforded a dimer (1)2 and mono-copper complexes (1-Cu, 1O2-Cu, and their methoxy derivatives), modulating the structures and […]Lingfang Zhang
- Divergent Synthesis of Planar/Central-Chiral [n]Metacyclophanes by Asymmetric Acylation March 28, 2026
