RSC – Org. Chem. Front. latest articles- Synthesis of sulfilimines via electron donor−acceptor complexes September 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01017A, Research ArticleWu Ke, Junliang Zhang, Junfeng YangSulfur-containing compounds have broad application prospects in chemical biology and medicinal chemistry. Herein we reported a Cu-catalyzed sulfilimine synthesis via arylation, alkylation and alkenylation of sulfenamides using readily accessible thianthrenium...The content of this RSS Feed (c) The Royal Society of ChemistryWu Ke
- Nickel-Catalyzed Synthesis of Aryl Ketones from Arylsulfonium Salts and Nitriles September 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01173F, Research ArticlePing Wu, Guan-Sheng Jiao, Cheng-Pan ZhangA useful method for the preparation of aryl ketones from arylsulfonium salts and nitriles via nickel catalysis is described. The reaction proceeds smoothly under mild conditions and exhibits obvious advantages,...The content of this RSS Feed (c) The Royal Society of ChemistryPing Wu
- Diels-Alder Reaction of Substituted Cyclopentadienones with Benzothiophene S, S-dioxides: Synthesis of Dibenzothiophenes, Dibenzothiophene S, S-dioxides, Acenaphthenes, Phenanthrenes, Pyrenes, and Fluorenones by Exploiting Thermolysis of Diels-Alder Adducts September 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00797F, Research ArticleDivya Bharathi K, MANIKANDAN Palani, Arasambattu K MohanakrishnanDiels-Alder (DA) reaction of a series of tetra substituted cyclopentadienones (CPDs) with benzo[b]thiophene S, S-dioxide analogues in various solvents at different temperatures led to the formation carbocyclic as well as...The content of this RSS Feed (c) The Royal Society of […]Divya Bharathi K
- Facile Access to Indolo[2,3-b]quinoline Alkaloids via DMSO-Mediated Cascade Cyclization: Unveiling Their Photophysical Potential September 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01193K, Research ArticleGokulprasanth Nataraj, Ranjithkumar Chandran, Muniappan Kalipriyadharshini, Diksha Bansal, Easwaramoorthi Shanmugam, Mrinal Kanti Das, Saikat ChaudhuriA streamlined and efficient synthetic strategy has been established for the construction of Indolo[2,3-b]quinolines, utilizing C3-alkylated indole as the starting material and mediated by DMSO and HCl. This methodology enables...The content of this […]Gokulprasanth Nataraj
- New mode of sulfur ylides reactivity: stereoelectronic control provides C–C bond insertion before cyclopropanation/epoxidation directly affording homologated three-membered rings September 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01266J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vitaly Shorokhov, Beauty K. Chabuka, Albina A Nikolaeva, Sergey S. Zhokhov, Ivan A. Andreev, Nina K. Ratmanova, Igor V. Trushkov, Olga Alexandrovna Ivanova, Igor AlabuginYlides are versatile reagents known for their dual […]Vitaly Shorokhov
- Selectfluor-Promoted Electrophilic Aromatic Halogenation: A General Strategy for Iodination and Bromination via Oxidative Halide Activation September 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01114K, Research ArticleFan Wu, Yuying Weng, Xubing Hu, Feng NiAryl iodides are indispensable intermediates in organic synthesis, yet direct C-H iodination of electronically diverse arenes under mild conditions remains challenging. Herein, we disclose a general and operationally simple C-H...The content of this RSS Feed (c) The Royal Society of […]Fan Wu
- Enantioselective organocatalytic electrochemical α-chlorination of aldehydes September 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01249J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stefano Andolina, Alessandra Puglisi, Sergio Rossi, Fabrizio Medici, Maurizio BenagliaThe enantioselective organocatalytic α-chlorination of aldehydes using electrochemistry to activate the enamine intermediate through a SOMO strategy was investigated.To cite this article before […]Stefano Andolina
- Ru-Diphosphine catalyzed asymmetric hydrogenation of unprotected β-C-glycosidic ketones September 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01085C, Research ArticleLimin Xu, Yuxuan Zhang, Yan Lu, Zhaoguo ZhangRu-catalyzed asymmetric hydrogenation of β-C-glycosidic ketones as functionalized ketones has been achieved, revealing the unusual coordination effect of the chiral hydroxyl groups in the substrates.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Limin Xu
- Transition metal-free transfer hydrogenation of aryl azides with alcohols: direct synthesis of secondary amines and N-heterocycles September 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01070E, Research ArticleJinwoo Lee, Ramachandra Reddy Putta, Junhwa Hong, Seung Hyun Choi, Honghui Lee, Seok Beom Lee, Suckchang HongA transfer hydrogenation of aryl azides with alcohols, promoted exclusively by alkali metal bases, has been developed. This protocol enables efficient C–N bond formation and is broadly applicable to the synthesis […]Jinwoo Lee
- Construction of Oxabicyclo[3.2.1]octanes via Palladium-Catalyzed Intermolecular [3+4] Cycloadditions of Vinylidenecyclopropane-diesters with Pyrroles or Indoles bearing a Trifluoroacetyl Group and the Related Hydroamination Reaction September 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01027F, Research ArticleBo Zhang, Ze-Ren Yang, Yin Wei, Min ShiIn this paper, we reported a palladium-catalyzed rapid construction of oxabicyclo[3.2.1]octane skeletons through an intermolecular [3+4] cycloaddition of vinylidenecyclopropane-diesters (VDCP-diesters) with pyrroles and indoles bearing a trifluoroacetyl group at the...The content of this RSS Feed (c) The Royal Society of […]Bo Zhang
- Access to spiro-isoxazolines via a palladium-catalyzed carboetherification of cycloalkenyl-tethered oximes September 23, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01162K, Research ArticleQicai Ma, Yuanyuan Li, Zhiping Liu, Chengming Wang, Wei ZhouWe have developed a practical and efficient tandem palladium-catalyzed carboetherification protocol, enabling the synthesis of a series of biologically relevant spiro-isoxazoline compounds.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Qicai Ma
- Rh-catalyzed [3 + 2] cyclization of (hetero)cyclic 1,3-dicarbonyls with 2-aminoarylboronic esters to access carbazolones September 23, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01079A, Research ArticleBei Wan, Ce Liu, Haoyuan Xiong, Yi Deng, Zhonghua Gu, Shaoyu Mai, Feng Qiu, Qingfeng DuThe first Suzuki-type [3 + 2] cyclization of cyclic 1,3-dicarbonyls with 2-aminoarylboronic esters has been developed. With eco-friendly EtOH/H2O as solvent, a series of structurally and electronically diverse carbazolones can be readily […]Bei Wan
- Synthesis of 3,3-dialkyl-substituted isochroman-1,4-diones via copper/photoredox dual-catalyzed carbolactonization of alkenes September 23, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01082A, Research ArticlePengfei Zhou, Ziyu Jin, Qiuping Ding, Jian-Qiang Chen, Jie WuWe report a general and concise method for modular synthesis of various 3,3-dialkyl-substituted isochroman-1,4-diones via copper/photoredox dual-catalyzed carbolactonization of alkenoic acids with NHPI esters.To cite this article before page numbers are assigned, use the DOI form of citation […]Pengfei Zhou
- Overcoming Steric Constraints in C-H Arylation via Pd/Ag Dual Catalysis: A Shortcut to Ortho-Tetrasubstituted Heterobiaryl N-Oxides September 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01137J, Research ArticlePeng Ye, Ya-Ling Zhang, ln xiong, Yang-Jie Mao, Yu-Qi Cui, Yong Luo, Dan-Qian Xu, Shao-Jie LouThe selective C-H arylation of N-containing aromatics with sterically demanding 2,6-disubstituted arylating reagents represents a straightforward way for the modular synthesis of ortho-tetra-substituted heterobiaryls, yet has remained scarcely explored due...The content of […]Peng Ye
- Palladium-Catalyzed Endocyclic Bond Cleavage of Thioxanthene-derived Sulfonium Salts September 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00862J, Research Articleyazhou lou, Chengfei Fu, Xing Chen, Junjie Zhao, Linglong Wan, Zhaoyu Sun, Xinhua LiuThe breaking of endocyclic S-aryl bond of strainless thioxanthene derivatives by transition metal-catalyzed ring-opening reactions are still underdeveloped. Herein, we presented the synthesis of unsymmetric triarylmethanes by desymmetric ring-opening reactions...The content of this RSS […]yazhou lou
- Sub-room temperature transfer hydrogenation of α,β-unsaturated ketones using methanol as a hydrogen source September 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01133G, Research ArticleSandip Bapu Khatal, Rahul Daga Patil, Manohar Shivaji Padmor, Sanjay PratiharA chemoselective transfer hydrogenation of α,β-unsaturated ketones at sub-room temperature (15–25 °C) using methanol and an Ir(III) pyridylidene–indole catalyst is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Sandip Bapu Khatal
- Saddle-shaped chiral nanographenes embedded with dipleiadiene and thia[6]helicene units September 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01263E, Research ArticleYufei Xia, Wang Sun, Qiao Yang, Li Jiang, Ying Wang, Yunbin Hu, Fengkun ChenA saddle-shaped chiral nanographene 2 and triple thia[6]helicene 4 were synthesized via controlled Scholl reactions, the electronic properties of which could be modulated by oxidation of the sulfur atoms.To cite this article before page […]Yufei Xia
- Lewis acid-mediated intermolecular [2π + 2σ] cycloaddition between enol ethers and bicyclo[1.1.0]butanes September 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01194A, Research ArticleShijie Zhu, Yukun Meng, Zhifei Zhao, Shi-Wu LiA Lewis acid-promoted [2π + 2σ] cycloaddition strategy enables the construction of bicyclo[2.1.1]hexanes (BCHs) from enol ethers and bicyclo[1.1.0]butanes (BCBs), with excellent functional group tolerance observed for both reactants.To cite this article before page numbers are assigned, use the DOI […]Shijie Zhu
- Diversity-oriented synthesis of poly-substituted benzofuran derivatives bearing amino groups at 2- or 3-positions: Rh- or Ni-catalyzed cycloisomerization between ynamides and enol ethers September 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01123J, Research ArticleShohei Ohno, Ray Miyazaki, Tomoyuki Tanaka, Keita Uehara, Jiawei Qiu, Hirona Itakura, Makoto Sako, Kenichi Murai, Jun-ya Hasegawa, Mitsuhiro ArisawaAmino-substituted benzofuran derivatives have attracted attention in recent years due to their remarkable biological activity.To cite this article before page numbers are assigned, use the DOI form of […]Shohei Ohno
- Cobaloxime catalyzed carbene insertion into N–H bonds: a streamlined route to α-amino esters with mechanistic insights September 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01185J, Research ArticleKeyang Wu, Kirklin L. McWhorter, Ayzia Ford, Liming Tan, Lidia M. Waidmann, Jesus O. Vazquez Hernandez, Madeline M. Garcia, Katherine M. Davis, Gang LiA cobaloxime-catalyzed N–H carbene insertion proceeds under mild conditions with low catalyst loading and broad amine scope. Mechanistic studies support a dominant cobalt–alkyl ylide […]Keyang Wu
- Synthesis of sulfilimines via electron donor−acceptor complexes September 29, 2025
