RSC – Org. Chem. Front. latest articles- Access to Chiral α-Methyl-α-Aryl Carboxylic Acids via Phosphoric Acid-Catalyzed Kinetic Resolution of Biaryl Oxazepines July 24, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00953G, Research ArticleGuimei Dai, Yifei Ma, Weiwei Tan, Ting Tu, Bowen Zhu, Zhikang Wei, Liejin Zhou, Shi-Chao Ren, Xing YangWe disclose herein a chiral phosphoric acid-catalyzed kinetic resolution of racemic biaryl oxazepines with alcohols, giving a series of biaryl oxazepines and imidate products bearing a chiral center in good...The […]Guimei Dai
- Synthesis of Multisubstituted Cyclohexenes and Cyclopentenes via Cascade Michael/Aldol/Annulative SuFEx/β-Sultone Desulfonation of β-Arylethenesulfonyl Fluorides July 24, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00837A, Research ArticleFang Zhang, Qichao Zhang, Pei Xie, Qifan Wang, Lin He, Zhihua Cai, Guangfen DuThe first β-sultone desulfonation facilitated diastereoselective synthesis of functional cyclohexenes and cyclopentenes is described. Under the mediation of Cs2CO3, γ-ketomalononitriles reacted with β-arylethenesulfonyl fluorides through a cascade Michael addition/aldol reaction/annulative...The content of this RSS […]Fang Zhang
- Electrostatic interaction-assisted regiospecific and oxidant free [4+2] annulation enabled by RhIII catalyzed C−H bond activation July 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00765H, Research ArticleXiaogang Cui, Renyi Diao, Rui Ma, Minglong Zhang, Chuan Zhu, Cheng-Qiang Wang, Chao FengA RhIII-catalyzed intermolecular [4+2] annulation reaction, employing N-tosylamide and carboxyl as the directing groups, has been developed herein. The utilization of readily accessible propargylic aminium triflate salts as coupling partners...The content of this RSS […]Xiaogang Cui
- Intramolecular Exciplex Formation Between Pyrene and Tetraazapyrene in Supramolecular Assemblies July 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00941C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xinyi Liu, Camila Negrete-Vergara, Simon Matthias Langenegger, Lorraine A. Malaspina, Simon Grabowsky, Robert Häner, Shi-Xia LiuTetraazapyrene (TAP), a nitrogen-substituted analogue of pyrene, features a planar and electron-deficient π-conjugation system, and thus can […]Xinyi Liu
- Utilisation of CO2 in the Simultaneous Installation of the C—C and C=C Bonds of α,β-Unsaturated Carboxylic Acids July 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00770D, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Amy Lowry, rachel E Lynch, Gerard P. McGlacken, Peter ByrneDevelopment of methods for the conversion of CO2 (a major waste product) into value-added chemicals has become an area of great interest. Herein […]Amy Lowry
- Correction: HBF4-mediated direct alcoholysis of amides under mild conditions July 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90055G, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shi-Zheng Liu, Wen-Heng Liu, Yaotai Deng, Qiang Li, Ming-Yu Dou, Yu Cui, Jian-Min DouTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Shi-Zheng Liu
- A main-chain [6]rotaxane: from synthesis to multi-stimuli-responsive motions July 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00930H, Research ArticleWentao Yu, Yidan Zhou, Zhiyao Yang, Juting Tan, Yimin Cai, Xiaowei Li, Wen Feng, Lihua YuanThe synthesis of higher order oligo[n]rotaxanes (usually n ≥ 3) featuring multi-stimuli responsive motions at the molecular level is critical for advancing artificial molecular machines and smart materials, yet achieving...The content of […]Wentao Yu
- Sulfonium salt formation-triggered regio-and Z-stereoselective phenoxythiolation of alkynes July 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00899A, Research ArticleMengke Su, Hanmiao Xu, Zengwei Lai, Jian WenSulfonium salts formation-triggered regio-and Z-stereoselective phenoxythiolation of terminal alkynes with phenols and sulfoxides which allows the synthesis of sulfur-containing aryl alkenylethers under the mild one-pot reaction conditions is reported. This...The content of this RSS Feed (c) The Royal Society of […]Mengke Su
- Computational investigation of palladium-catalyzed allene–allene cross-coupling July 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00617A, Research ArticleFeiyun Jia, Chenghua Zhang, Yongsheng Yang, Xueting Zheng, Mingjin Shen, Jun Dong, Mingsong ShiA palladium-catalyzed allene–allene cross-coupling mechanism was established.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryFeiyun Jia
- Rh2(II)-catalyzed cyclization/gem-hydrosilylation of benzene-fused 1,6-enynones July 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00835B, Research ArticleZurong Xu, Jiajun Lu, Rui Wu, Shifa ZhuDirhodium(II)-catalyzed cyclization/geminal hydrosilylation of 1,6-enynes that accommodates primary, secondary and tertiary silanes is reported. This protocol enables one-step synthesis of bicyclo[3.1.0]hexanone silanes and naphthol-derived silanes.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Zurong Xu
- Quinoline-Substituted Excited-State Intramolecular Proton Transfer Fluorophores as Stimuli-Sensitive Dual-State Fluorophores July 20, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00639B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Timothée Stoerkler, Gilles Ulrich, Adèle D Laurent, Denis Jacquemin, Julien MassueThis article describes the synthesis along with full photophysical and ab initio properties of a series of 2-(2’-hydroxyphenyl)benzoxazole (HBO) fluorophores, a family […]Timothée Stoerkler
- Visible-light induced C(sp3)–S cross-coupling via electron donor–acceptor complexes and 1,2-hydrogen atom transfer July 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00824G, Research ArticleXue Zhang, Liulin Jiao, Jian Chen, Hongying Fan, Jinyu Hou, Guanghui Lv, Zhongzhen Yang, Yong WuHerein, we disclose a visible light-mediated protocol for the C(sp3)–S cross-coupling reaction via 1,2-hydrogen atom transfer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Xue Zhang
- An umpolung of transient arylidene malonates via photoactivated one-electron reduction: the application to the catalyst-free multicomponent synthesis of imidazolinone malonic acids July 20, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00768B, Research ArticleAidar Z. Kamaletdinov, Elizaveta A Kuznetsova, Andrey V Smolobochkin, Almir Gazizov, Tatyana Gerasimova, Aliya Saitova, Anna Strelnik, Victor Vasil'evich Syakaev, Sergey Efimov, Vladimir Klochkov, Olga Babaeva, Vasily Babaev, Lyubov V Frantsuzova, Daria P. Gerasimova, Mikhail Khrizanforov, Alexander Burilov, Michail PudovikThe Meldrum’s acid-based multi-component reactions have emerged as […]Aidar Z. Kamaletdinov
- Zwitterionic triple- and quadruple hydrogen-bonding motifs July 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00874C, Research ArticleQixun Shi, Kai Liu, Chuang Ye, Augustina Jozeliūnaitė, Vytautas Klimavičius, Jas S. Ward, Kari Rissanen, Edvinas OrentasNovel stimuli-responsive zwitterionic modules based on ureidopyrimidinone and isocytosine scaffolds are presented in this work.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Qixun Shi
- Phosphorus catalysis enabling α-sp3-C–H amination of 2-alkylpyridines July 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00960J, Research ArticleYoshito Heike, Asa Tagata, Akira Yada, Kanako Nozawa-Kumada, Masaya Sawamura, Yohei ShimizuPhosphorus-catalyzed sp3-C–H amination of 2-alkylpyridines was developed as a notable advancement of a catalytic sp3-C–H functionalization by an organophosphorus compound.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Yoshito Heike
- Conversion of Phenols to Phosphamides and Sulfonamides through a Sequential Dearomative Functionalization followed by Reductive Coupling Strategy July 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00811E, Research ArticleHaripriya Bhumannagari, Nagaraju Rajana, Kiranmai NayaniEfficient and direct conversion of phenols to arylphosphamides and arylsulfonamides has been achieved using a sequential oxidative dearomative functionalization-reductive coupling strategy. The earlier methods involve use of azides or amines...The content of this RSS Feed (c) The Royal Society of ChemistryHaripriya Bhumannagari
- Inorganic Reagents in photochemical Reactions July 17, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00888C, Review ArticleZhan-Yong Wang, Ziyan Zhang, Yang Liu, Yumeng Li, Xinyue Dong, Ran XiaInorganic reagents are safe, low-cost, easy to store, and easy to remove after a reaction. These properties make them attractive for direct use in organic synthesis. Inorganic reagents can serve...The content of this RSS Feed (c) […]Zhan-Yong Wang
- Exploring the intricacies of inverse hydride shuttle catalysis in azabicyclic scaffold construction with contiguous stereocenters July 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00627A, Research ArticleDamanpreet Kaur, Saurabh Vinod Parmar, Aniket Nigade, Vidya AvasareFrom achiral to chiral: elucidating the reaction mechanism involved in the construction of three contiguous stereocenters in azabicyclic compounds without chiral precursors or catalysts.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Damanpreet Kaur
- Construction of fused BN-heterocycles via boron atom insertion: DFT insights into the Lewis acid–base (BBr3/NEt3) cooperative mechanism and selectivity July 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00870K, Research ArticleJingxin Hu, Lin Zhang, Zexing CaoDFT calculations indicate that the Lewis acid–base cooperation between BBr3 and NEt3 facilitates the formation of the nucleophilic species BBr4− and enables the ring-opening of N-heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Jingxin Hu
- Combined photoredox and carbene catalysis: alkene borocarbonylation via the persistent radical effect July 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00819K, Research ArticleXiaochen Wang, Senhui Wu, Hongyu Zhang, Qingmin Wang, Shurong BanHerein, we report a mild and operationally simple dual-catalytic method for the synthesis of β-boryl carbonyl compounds via alkene difunctionalization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Xiaochen Wang
- Access to Chiral α-Methyl-α-Aryl Carboxylic Acids via Phosphoric Acid-Catalyzed Kinetic Resolution of Biaryl Oxazepines July 24, 2025
