RSC – Org. Chem. Front. latest articles- Flow Chemistry-Assisted Visible Light-Induced Radical Addition of β-Amino Iodides with Enones en Route to Efficient Construction of cis-2,6-Piperidines February 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01747E, Research ArticleYufan Yang, Dongxu Wang, Dongyang Jiang, Kaixuan Pan, Yingchen Wang, Luai Ji, Wanshu Wang, Lu Gao, Fu Peng, Zhenlei SongA visible light-induced radical coupling of β-amino iodides and enones has been developed. This transformation offers efficient access to 1,5-amino ketones (25 examples, 71-96% yield), which serve as […]Yufan Yang
- Electrochemically Enabled C7 Functionalization of Quinolines from o-Propynolanilines: Divergent Access to 4,7-Dichloro and 4-Chloro-7-alkyl (aryl) Quinolines February 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01687H, Research ArticleXin Feng, Qiuqin He, Renhua Fan, Jiwen HeThe regioselective functionalization of the C7 position of quinoline remains a formidable challenge due to its inherent electronic deactivation. Herein, we report an electrochemical strategy that enables divergent synthesis of...The content of this RSS Feed (c) The Royal Society of […]Xin Feng
- Electrochemical Deuteration of Allylic Esters with Divergent Site-Selectivity February 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01759A, Research ArticleXu Zhang, Ke Liu, Mohan Wang, Chao Wu, Xiaoli Wang, Man-Bo Li, Sheng ZhangDeuterium-labelling technology has emerged as a new promising direction for the pharmaceutical discovery. Developing a divergent protocol to incorporating deuterium into different sites of bioactive molecules is highly desirable, as...The content of this RSS […]Xu Zhang
- Synthesis of α-sulfenylated carbonyl compounds via combining gold-catalyzed rearrangement and photoinduced nickel-catalyzed Giese reaction February 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01721A, Research ArticleYue-Liu-Ting Fu, Yun-Long Han, Liang-Qiu Lu, Ying Cheng, Wen-Jing XiaoA general process for synthesizing α-sulfenylated carbonyl compounds has been developed, involving a two-step procedure. This protocol employs gold-catalyzed rearrangement of propargylic sulfoxides followed by visible-light-induced nickel-catalyzed Giese reaction of...The content of this RSS Feed (c) The Royal […]Yue-Liu-Ting Fu
- Recent Advances in Visible-Light-Induced Defluorinative Functionalization of α-Trifluoromethyl Arylalkenes February 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01732G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yanyan He, Leiyang Lv, Zhenhua Jia, Teck Peng LohFluorine-containing organic molecules have been widely utilized in the fields of medicinal chemistry, synthetic chemistry, agrochemistry and materials science, due to their higher lipophilicity, […]Yanyan He
- Blue light-promoted [2 + 4] cycloaddition of phosphe-nes and N-acylimines: Highly diastereoselective access to 3,4-dihydro-1,5,2-oxazaphosphinine 2-oxides February 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00019C, Research ArticleMengyao Zhang, Chongjie Su, Hongguang Du, Jiaxi XuBlue light promoted reaction of phosphoryl diazomethanes and N-acylimines accesses 3,4-dihydro-1,5,2-oxazaphosphinine 2oxides in satisfactory to excellent yields with excellent diastereoselectivities. The reaction is a tandem sequence of the light-induced Wolff...The content of this RSS Feed (c) The Royal Society of […]Mengyao Zhang
- Pd(II)-Catalyzed Aerobic Dual C–N Bond Formation: Oxygen-Dependent Divergence between Dihydroquinazolinone and Aza-Michael Pathways, an Experimental and Computational Study February 6, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01381J, Research ArticleNarges Mohammadi, Farnaz Jafarpour, Leyla Mohammadkhani, Alireza AriafardWe report an aerobic three-component reaction of isatoic anhydrides, anilines, and acrylamides that simultaneously forms two distinct C–N bonds through two sequential Pd(II)-catalyzed cycles, affording 2,3-dihydroquinazolin-4(1H)-ones (DHQs) incorporating β-amino carbonyl...The content of this RSS Feed (c) The Royal Society of […]Narges Mohammadi
- CHA-Initiated [3 + 2 + 1] Spiroannulation of Enaminone with Diazo Oxindole Leading to Concise and Divergent Synthesis of Oxindole Spirohydropyridines February 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01702E, Research ArticlePengkuo Shi, Chun Yang, Nana Shen, Haiyun Xu, Xinying Zhang, Xuesen FanPresented herein is a concise and divergent synthesis of oxindole spirohydropyridine derivatives based on the reaction of enaminone with diazo oxindole. In forming the hydropyridine skeleton, one enaminone acts as...The content of this RSS Feed (c) […]Pengkuo Shi
- Diels-Alder Dimerization of Ene-Allenes and Enyne-Allenes Generated via the Propargylic Alder-Ene Reaction of Diynes and Triynes February 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01454A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kumudi Jayanada Weerasinghe Rajapaksa, Duy-Viet Vo, Wu Tong Tong, Yanshu Luo, Eunhye Lee, Yuanzhi Xia, Daesung LeeEfficient Diels-Alder dimerizations of ene-allenes and enyne-allenes to generate highly functionalized spirocycles and the DFT studies […]Kumudi Jayanada Weerasinghe Rajapaksa
- Skeletal diversity-oriented synthesis of cycloheptatriene[b]indole, spiro-cyclopentene[b]indole and carbazole derivatives via Pd-catalyzed domino reaction involving indolyl allene intermediates February 3, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01651G, Research ArticleYu Xin, Xinxin Chen, Zebang Meng, Ruwei Shen, Shugao ZhuThe Pd-catalyzed tandem reactions provide efficient access to cycloheptatriene[b]indole, spiro-cyclopentene[b]indole and carbazole skeletons with high selectivity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Yu Xin
- A metal-free or metal e-waste catalysed alkyne hydration–condensation–decarboxylation cascade reaction in water gives access to (fused) carbocycles February 3, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01729G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alejandro Lumbreras-Teijeiro, Daniel Pérez de los Cobos-Pérez, Susi Hervàs-Arnandis, Marta Mon, Judit Oliver-Meseguer, Antonio Leyva-PérezThe ester-assisted hydration reaction of alkynes proceeds with just protons and recovered e-waste gold catalysts in aqueous media […]Alejandro Lumbreras-Teijeiro
- Palladium-catalyzed Z-selective alkynylation of gem-difluoro alkenes via carbon–fluorine bond activation: mechanistic insights into oxygen-directed regiocontrol January 29, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01674F, Research ArticleXin Liu, Min Liang, Jingyi Guo, Jin Yang, Jingyu Zhang, Yingsheng ZhaoPd-catalyzed fluoroamino acid C–C coupling achieves Z-alkene synthesis via O-Pd stereocontrol. Validated mechanistically, pioneers amino acids as catalytic directors for fluorinated dehydroalkynyl derivatives.To cite this article before page numbers are assigned, use the DOI form of […]Xin Liu
- Synthesis of Chiral α-Trifluoromethyl amines via Asymmetric reaction of Trifluoromethylated Imines January 29, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00001K, Review ArticleWei Chen, Wei Chen, Qin Yang, Yiyuan PengChiral fluorinated amine compounds are valuable and important synthetic intermediates for the synthesis of biologically active compounds and natural products. Therefore, developing efficient synthetic methods for these compounds holds great...The content of this RSS Feed (c) The Royal Society of […]Wei Chen
- An iodonium based cross-linking tool for tyrosine conjugation January 29, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01572C, Research ArticleRihárd Sisa, János T. Csenki, Flavián Domány, Dóra Ágocsi-Kiss, Levente Dókus, Gábor Mező, Péter P. Fehér, András Stirling, Anna J. Kiss-Szemán, Zoltán NovákSelective fluoroalkenylation of tyrosine enables peptide cross-linking using a fluoroalkyl-aryl iodonium salt derived from HFO1234yf gas, forming unique 1,2-diaryloxyethene linkers. The mechanism was investigated and […]Rihárd Sisa
- Tandem Scholl reaction for the synthesis of twisted nanographenes January 28, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00004E, Research ArticleZixian Wu, Zheng Zhou, Yuanjian Zhang, Yong YangTwo twisted nanographene molecules are synthesized by the one-pot tandem Scholl reaction. The unique helical–axial–helical structure endows three stereogenic elements in a π-framework.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Zixian Wu
- Palladium-catalyzed decarboxylative [4 + 2] cycloaddition of δ-vinylvalerolactones for the synthesis of spirocyclohexane compounds January 28, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01724F, Research ArticleWei Sun, Xue-Song Peng, Guo-Yin Sun, Juan Liao, Lei Yang, Yan-Ping Zhang, Jian-Qiang Zhao, Ming-Qiang Zhou, Wei-Cheng YuanAll-carbon π-allylpalladium species, generated in situ from α,α-diester-δ-vinylvalerolactones, were first used as 1,4-dipoles in [4 + 2] cycloaddition reactions for the construction of structurally diverse spirocyclohexanes.To cite this article before […]Wei Sun
- Hydrogen-bond-assisted configurational diversity of benzamidines: experimental and theoretical study January 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01450F, Research ArticleEdem R. Chakalov, Daria I. Tonkoglazova, Anna A. Titova, Maxim L. Kruglov, Elena Yu. Tupikina, Alexander S. Antonov, Peter M. TolstoyNMR spectroscopic studies of N,N′-diarylbenzamidines reveal the solvent-dependent dynamic interconversion between all four isomers, E-anti, E-syn, Z-anti and Z-syn, some of which are prone to either linear […]Edem R. Chakalov
- Remote C(sp3)–H cyanation and deuteration of amides via photoredox catalysis January 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01746G, Research ArticleWen-Jie Yan, Jia-Lin Tu, Zhuohua Li, Lin Guo, Jiabin Shen, Chao Yang, Wujiong XiaA photo-induced remote and selective C(sp3)–H cyanation and deuteration reaction of amide is herein reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Wen-Jie Yan
- Samarium diiodide-mediated radical thioetherification of alkyl bromides with thiols by ruthenium catalysis January 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01523E, Research ArticleYongqi Liang, Kexin Li, Yongmei Cui, Chengwei LiuA robust samarium diiodide-mediated radical thioetherification of alkyl bromides with thiols via ruthenium catalysis is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Yongqi Liang
- Densely-functionalized bicyclic cyclopentanones by combined photoinduced 6-endo-trig Giese additions and mild aldol cyclizations January 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01635E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Júlia Viñas-Lóbez, Nicolas Sellet, Bibiana Fabri, Guillaume Levitre, Adiran de Aguirre, Amalia I. Poblador-Bahamonde, Céline Besnard, Jérôme LacourA photoredox-enabled synthesis of trans-fused [n.3.0] bicyclic ketones via 6-endo-trig radical additions and mild aldol […]Júlia Viñas-Lóbez
- Flow Chemistry-Assisted Visible Light-Induced Radical Addition of β-Amino Iodides with Enones en Route to Efficient Construction of cis-2,6-Piperidines February 7, 2026
