RSC – Org. Chem. Front. latest articles- Cu(I)-catalyzed, N-Fluorobenzamides Enabling 1,2-Carbofluorination of Unactivated Alkenes via Free Radical Relay March 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01763G, Research ArticleHong Ji, Haifeng Qiao, Boyi Wang, Tianyu Lu, Weixing Chang, Lingyan Liu, Jing LiThe construction of carbon-fluorine bond has always remained challenging. This work described a two-component 1,2carbofluorination bifunctionalization of unactivated alkenes through a free radical relay process. The N-fluorobenzamide was firstly used...The content of this RSS […]Hong Ji
- Photocatalyzed regioselective arylation of trialkylamines March 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01719J, Research ArticleJiamin Wu, Xin Wang, Kuai Wang, Ling-Guo MengEasily available trialkylamines are increasingly utilized as coupling partners with diverse hydrocarbons to construct various complicated amine frameworks. However, controlling the regioselectivity of these reactions remains a significant challenge. We...The content of this RSS Feed (c) The Royal Society of […]Jiamin Wu
- Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated March 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01481F, Research ArticleLong-Jin Zhong, Xuan Shang, Pengfei Huang, Quan Zhou, Changhui Liu, Yu LiuWe report a study on the use of ligated boryl radicals for the synthesis of nitrogen-containing polycyclic compounds under photocatalytic conditions through a halogen-atom transfer (XAT) strategy. This approach leverages...The content of this RSS Feed (c) […]Long-Jin Zhong
- EtAlCl2 -Promoted Defluorinative Thiolation of α-Trifluoromethyl Alkenes March 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00011H, Research ArticleXin Guo, Guoliang Pu, Long Xiao, Jiarui Liang, Hang Zhang, Yu Chen, Yang Huang, Qiuli Yao, Chun-Yang HeHere, we report a EtAlCl2-promoted thiolation of trifluoromethyl alkenes, which leads to the complete substitution of all three fluorine atoms and affords trisubstituted products. Although the transformation proceeds through a...The […]Xin Guo
- Engineering Tetraphenylethene-Based Z and E Stereoisomers: Structural Analysis and Sensing Application February 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00075D, Research ArticleHan-Jiang Yang, Yatuan Ma, Xinpei Zhong, Xin Yang, You Xu, Xiaoxue Zhang, Zhixin Xiang, Xiujuan Huang, Wenji Wang, Jinyi Wang, Maosen YuanThe exploration of Z/E stereoisomers represents an interesting and significant endeavor in molecular engineering. We developed three pairs of tetraphenylethylene (TPE) derivatives modified by heteroatom-containing trivalent […]Han-Jiang Yang
- Polysubstituted bicyclo-[2.1.1]-hexanes as benzene isosteres for medicinal chemistry February 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01662B, Review ArticleEugenio Roà, Quentin LefebvreThis comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Eugenio Roà
- Oxidation Reactions in the Current Total Synthesis of Natural Products February 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00050A, Review ArticleJian-Feng Zheng, Anqi Chen, Yan-Jiao Gao, Pei-Qiang HuangOxidation and oxidative reactions are a type of fundamental transformation in organic chemistry, which are indispensable for organic synthesis, especially for the total synthesis of natural products. Although there are...The content of this RSS Feed (c) The Royal Society of […]Jian-Feng Zheng
- Aryl Imidazoisoindoles for Intrinsic 10π Pericyclic Photochromism with Nonlinear Acid Responsiveness February 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00016A, Research ArticleTaichi Muto, Chigusa Goto, Shohei Katao, Tsuyoshi KawaiPhotochemical and thermal peri-cyclization and cycloreversion reactions of organic polyenes are typically governed by orbital symmetry considerations. Here, we report two aryl-imidazoisoindole derivatives featuring benzene and thiophene rings that undergo...The content of this RSS Feed (c) The Royal Society of […]Taichi Muto
- An air-stable chiral P,N-ligand/PdCl2 partner enables a highly enantioselective oxidative homocoupling of naphthylboronic acids/boronates only in an oxygen atmosphere February 26, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01752A, Research ArticleGuo Cheng, Jing-Liang Yu, Qian-Mao Zhang, Zhen-Yu Yang, Fang Tian, Li-Xin WangA highly enantioselective oxidative homocoupling of naphthylboronic acids/boronates was achieved for the first time in the presence of an easily available chiral P,N-ligand/PdCl2 complex only in an oxygen atmosphere at high temperature conditions.To cite this article […]Guo Cheng
- Interactions beyond H-bond: Unveiling the role of unorthodox non-covalent interactions in charged thiourea and its catalytic efficiency February 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01735A, Research ArticlePrabhahar Murugan, Parul Rathour, Dipankar Das, Brijesh Patel, Srinu Tothadi, Biswajit Ganguly, Saravanan SubramanianThe development of catalyst with a rapid turnover rate under ambient reaction condition is highly desired. Inspired by the biocatalytic systems, the field of charge-driven catalysis provide useful guidelines for...The content of this RSS […]Prabhahar Murugan
- B-spiroBODIPYs as a fluorophore responsive to hydrogen bond donors February 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00102E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aiko Kondo, Hideaki Takano, Hiroshi ShinokuboWe demonstrate an Au-catalysed synthesis of B-spiroBODIPYs with a 1,3-dioxinone moiety. The B-spiroBODIPY exhibits solvent-dependent fluorescence arising from hydrogen-bonding interactions, which offers a platform for stimulus-responsive probes.To […]Aiko Kondo
- Enantioselective synthesis of atropisomeric biaryls and heterobiaryls via transition metal-catalyzed cyclization February 25, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01492A, Review ArticleShibo Lin, Ya Zou, Yiwen Chu, Junfeng Deng, Lifeng ZhaoAtropisomeric architectures with a chiral axis are prevalent in biologically active molecules and natural products, and they are widely put to use in privileged catalysts and chiral ligands.To cite this article before page numbers are assigned, use the […]Shibo Lin
- β-and Z-Selective Metal-Free Cyanation of Ynamides: A Direct Approach to Piperidines Fused to Arenes February 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00022C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dorian Schutz, Wenwen Yang, Laurence MieschMetal-free βand Z-selective hydrocyanation of terminal ynamides using TMSCN and TBAF is described. The transformation proceeds with excellent regio-and stereoselectivity, delivering exclusively Z-configured tertiary enamides. Treatment with […]Dorian Schutz
- Group 14 heavier 1,4-dimetallabenzenes: influence of aromaticity, open-shell character and strain on small molecule activation February 24, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00006A, Research ArticleDaniel González-Pinardo, Israel FernándezThe influence of the aromaticity, diradical character and strain on the reactivity of group 14 heavier 1,4-dimetallabenzenes (E = Si, Ge, Sn, Pb) has been investigated using quantum-chemical calculations.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Daniel González-Pinardo
- Palladium/copper bimetallic system-catalyzed cascade cyclization of N-allyl ynamides and o-haloanilines: access to multifunctional benzimidazoles February 24, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00038J, Research ArticleYi-Yun Zhang, Xu-Heng Yang, Ai-Ming Wen, Fang Wang, Jian Huang, Jianfang Wang, Cheng-an TaoA one-pot synthesis of 1,2-disubstituted multifunctional benzimidazole derivatives starting from N-allyl ynamides and o-haloanilines has been introduced. The reaction could also be performed on a multi-gram scale with the same efficiency.To cite this article […]Yi-Yun Zhang
- Enantioselective Synthesis of Allylic Boronates bearing a Stereodefined (E)-Alkenyl Chloride by Cu-Catalyzed Borylation of Allylic gem-Dichlorides February 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00061D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrea Chaves-Pouso, Andrés Manuel Álvarez Constantino, Patricia Gomez Roibás, Martín Fañanás-MastralChiral α,γ-substituted allyl boron reagents are valuable tools in organic synthesis. However, asymmetric catalytic strategies for synthesising this type of compounds bearing […]Andrea Chaves-Pouso
- Divergent Transformations of N-Phenyl-N-tosylfluoroacetamides to Amides and Imides (N-Tosylamides) February 24, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00069J, Research ArticleNan Wang, Xia Chen, Chun-Yan Liu, Zhi-Ying Feng, Ming Bao, Xiao-Yu ZhouThe strained C−N bond of N-phenyl-N-tosylfluoroacetamides is activated via transition-metal-free nucleophilic addition pathway by employing suitable nucleophilic reagents, such as indoles, indolines, aryl amines and carboxylic acids. Based on this,...The content of this RSS Feed (c) […]Nan Wang
- Theoretical investigation on the mechanism of Ni0(acetylide carbanion)-ate complex-catalyzed C(sp2)–F bond activation and the origin of the counterion effect on reactivity February 23, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01757B, Research ArticleXiao-Xia You, Ling-Qi Meng, Xu Liu, Li-Li Wang, Xin-Cheng Xu, Rong-Lin Zhong, Zhong-Min SuDFT calculations reveal that C(sp2)–F bond activation proceeds via an inner-sphere Ni0-mediated SNAr pathway enabled by a Ni0(acetylide carbanion)-ate complex, where acetylide coordination enhances nucleophilicity at the Ni0 center.To cite this article before page […]Xiao-Xia You
- Pd(PPh3)4-catalyzed regioselective C–H para-allylation of N,N-dialkylanilines using vinyl benzoxazinanones February 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00093B, Research ArticleLu Pei, Xiao-Lin Liu, Ding-Jun Zhang, Hui-Hong Tian, Ling-Dan Zhu, Bang-Guo WeiA Pd(PPh3)4-catalyzed regioselective C–H para-allylation process was developed for the reaction of N,N-dialkylanilines with vinyl benzoxazinanones. A series of N,N-dialkylaniline derivatives were excellently synthesized.To cite this article before page numbers are assigned, use the DOI form […]Lu Pei
- Advances in the construction of boryl cyclobutanes February 21, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00008H, Review ArticleKanak Kanti Das, Sutapa DeyRecent advances in the synthesis of boryl-substituted cyclobutanes are summarized, highlighting strain-release, boronate complex reactivity, 1,2-migration, and catalytic strategies for stereocontrolled access to sp3-rich building blocks.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Kanak Kanti Das
- Cu(I)-catalyzed, N-Fluorobenzamides Enabling 1,2-Carbofluorination of Unactivated Alkenes via Free Radical Relay March 2, 2026
