RSC – Org. Chem. Front. latest articles- Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls August 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00816F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lucía Sánchez-Jiménez, Adrián Gargantiel, Manuel A. Fernández-Rodríguez, Patricia García-GarcíaDivergent gold-catalyzed cycloisomerizations of o-cyclopropylidenemethyl-o′-alkynylbiaryls give access to two distinct polycyclic scaffolds containing a tricyclic bridgehead carbon center, with selectivity controlled by temperature.To cite […]Lucía Sánchez-Jiménez
- Pd-Catalyzed Hydroesterification of Vinyl Cyclopropanes with Aryl Formates August 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00634A, Research ArticleJunhua Li, Chunyin Li, Jing Li, Zhanwei Wang, Fengyin Wang, Yian ShiA Pd-catalyzed hydroesterification of vinyl cyclopropanes with aryl formates is described. A wide variety of cyclopropane-containing or ring-opening carboxylic esters can be obtained in good yields under mild reaction conditions....The content of this RSS Feed (c) […]Junhua Li
- Light-Promoted Cobalt-Catalyzed Radical Markovnikov Hydrothiolation of Alkenes with N-Arylsulfenyl Phthalimides August 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01020A, Research ArticleXiang-Rui Li, Rong-Jin Zhang, Ting-Ting Miao, Yonghong Xiao, Kun-Quan Chen, Jian-Ji ZhongIn recent years, transition-metal hydride catalysis has emerged as a powerful strategy for radical Markovnikov hydrothiolation of alkenes, providing efficient access to branched thioethers. However, this approach remains underexplored, with...The content of this RSS Feed (c) […]Xiang-Rui Li
- Diastereo- and enantioselective construction of 1,4-nonadjacent alkyne-tethered products through CuI-promoted deprotonation and addition of terminal alkynes August 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00995B, Research ArticleJiale Zheng, Wan-Hong Yuan, Han-Wen Zheng, Wei Du, Ying-Chun ChenWhile catalytic asymmetric alkynylation reaction has been extensively studied, existing examples predominantly focus on the construction of stereogenic center at the addition site. Here we disclose a chiral CuI complex-catalysed...The content of this RSS Feed (c) The Royal […]Jiale Zheng
- Radical Conjugate Addition to 2-Substituted Chromones via Electron Donor-Acceptor Complex August 20, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00933B, Research ArticleYunbi Koh, GaYeon Yoo, Jinsung Tae, Sanghee Lee, Ansoo LeeA novel photocatalyst-free radical conjugate addition to 2-substituted chromones has been developed, utilizing Hantzsch esters and TMSOTf to efficiently access diverse 2,2-disubstituted chroman-4-ones under mild conditions. Mechanistic studies, including UV–vis...The content of this RSS Feed (c) The Royal […]Yunbi Koh
- Conformation-tunable hydrogen-bonded calix[2]aramide macrocycles: bridging aggregation-induced emission and charge-transfer host-guest chemistry August 20, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00987A, Research ArticleZiying Lu, Xiongrui Ai, Yingxiao Mu, Mingbing Lian, Yanping Huo, Zecong YeTwo novel hydrogen-bonded calix[2]aramide (C[2]A) macrocycles were successfully synthesized by linking crescent aramide tri-mers via methylene bridges. The macrocycles exhibited aggregation-induced emission and clusterization-triggered emission phe-nomenon, enhanced solid-state luminescence efficiency...The content of this RSS Feed (c) […]Ziying Lu
- Synergistic Ni/Co Catalysis in C(sp 2 )-C(sp 3 ) Reductive Coupling: A DFT Study August 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00975H, Research ArticleJunjie Liu, Fengjiao Xiao, Weichi Chen, Abing DuanIn nickel-catalyzed C(sp 2 )-C(sp 3 ) cross-coupling, employing cost-effective cobalt complexes as co-catalysts presents distinct advantages. The Ni/Co dual-catalyzed reductive coupling of aryl halides and alkyl has emerged as...The content of this RSS Feed (c) The Royal Society of […]Junjie Liu
- The Stereochemistry of Substitution at S(VI) August 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01043H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Oliver Symes, James A BullSince the re-birth of sulfur-fluoride exchange (SuFEx) chemistry, coined by Sharpless in 2014 as a ‘click’ reaction, the prevalence of sulfur(VI) moieties in medicinal, polymer and materials chemistry […]Oliver Symes
- Cooperative N-Heterocyclic Carbene/Photocatalysis: Visible-light promoted tandem α-sp3 C–H activation and reductive N-alkylation of Tetrahydroisoquinolines August 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01032B, Research ArticleKarthiyayini Gnanaoli, Deepan Babu Rajkumar, Uma C. MaheswariWhile N-heterocyclic carbenes (NHCs) have played a vital role as organocatalysts due to their Umpolung reactivity toward carbonyl or imine carbons, activation of sp³-carbons via single-electron transfer (SET) processes remains...The content of this RSS Feed (c) The Royal Society of […]Karthiyayini Gnanaoli
- Bypassing the Abnormal Chichibabin Reaction Dead-End Provides a Biomimetic Access to Pre-Haouamine August 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01111F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Axel Leblond, Erick Caique Costa, Karine Leblanc, Edmond Gravel, Jean-François Gallard, Mehdi Beniddir, Erwan PouponHaouamines are highly constrained marine alkaloids possessing a unique in nature skeleton. The high degree of complexity of […]Axel Leblond
- Nickel-catalyzed [4 + 1] sila-cycloaddition: a divergent synthesis of silacarbocycles from trichlorosilanes August 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01018G, Research ArticleLiangliang Qi, Peng-Fei Xu, Yu-Ke Wu, Xiaobo Pang, Xing-Zhong ShuCyclic chlorosilane transformations present a valuable opportunity for the divergent synthesis of silacarbocycles, but their low availability has hindered this potential.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Liangliang Qi
- Manipulating stereo-communication in binaphthol-bridged α- and β-cyclodextrins to develop β-selective chiroptical pH switching and anion sensing in water August 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00910C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Giovanni Preda, Sonia La Cognata, Laura Pedraza-González, Laurine Carlier, Maxime Kolb, Gennaro Pescitelli, Valeria Amendola, Dominique Armspach, Dario PasiniThe unfavourable stereocommunication mode between cyclodextrins and binaphthyls translates into highly responsive chiroptical behavior, […]Giovanni Preda
- Rhodium-Catalyzed Hydroselenation of Unsymmetric 1,3-Dienes with 3,4-Markovnikov Regioselectivity August 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00926J, Research ArticleAnee Taj, Chen Cui, Zhenwei Shi, Xuebin Huang, Xiao-Hui YangCatalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetrical 1,3-dienes, including...The content of this RSS Feed (c) The Royal […]Anee Taj
- Copper-catalyzed three-component 1,2-aryl sulfonylation of vinylarenes and 1,3-dienes with sodium sulfinates August 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00993F, Research ArticleWei-Hao Rao, Chang Gao, Li-Li Jiang, Xiao-Wen Dong, Yi-Wen Li, Chen-Xi Ge, Jia Li, Meng-Cheng ZhangA copper-catalyzed three-component 1,2-aryl sulfonylation of vinylarenes and 1,3-dienes with sodium sulfinates is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Wei-Hao Rao
- Photocatalytic ketone synthesis: recent advances in radical-based approaches from carboxylic acids and derivatives August 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01059D, Review ArticleShengbiao Yang, Xiaochen Wang, Lan Bao, Tianzhen Wang, Lingang Wu, Qingmin WangThis review systematically summarizes the photocatalytic strategies for constructing ketones from carboxylic acids and their derivatives, emphasizing single-electron radical pathways.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Shengbiao Yang
- Palladium/photoredox catalysis for a decarboxylative radical C(sp3)–C(sp3) cross-coupling reaction of γ-methylidene-δ-valerolactones with alkyl carboxylic acids August 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01005E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ran Song, Jiaxing Li, Lin Li, Huaixi Mu, Wei Feng, Daoshan Yang, Wen Si, Jian LvA radical decarboxylative Csp3–Csp3 cross-coupling of γ-methylidene-δ-valerolactones and non-preactivated alkyl carboxylic acids was developed by combining photocatalysis […]Ran Song
- Atroposelective [5 + 5] formation of benzo[c]chromenone and phenanthridinone by carbene organocatalysis August 12, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00986C, Research ArticleKe Xu, Kejun Lin, Jiayi Zhao, Jingmei Zeng, Tingshun ZhuAn atroposelective [5 + 5] annulation strategy for synthesizing chromenones and phenanthridinones via carbene organocatalysis has been developed. The method enables the efficient construction of axially chiral biaryls with gradient rotation barriers.To cite this article before page numbers […]Ke Xu
- Mechanochemical Production of Biphenyls from Nitrogen-Containing Organic Compounds: Amides, Anilines, and Sulfonamides August 11, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01041A, Research ArticleSatenik Mkrtchyan, Gabriela Addová, Juraj Filo, Khurshid Ayub, Michael G Garcia, Spartak Spiridonovich Khutsishvili, Yevhen Karpun, Elena Kupcová, Vishal B. Purohit, Sehrish Sarfaraz, Mohanad Shkoor, Barbora Benicka, Oleksandr Shalimov, Vitaliy Yepishev, Jiří Zapletal, Viktor IaroshenkoThe presence of C(sp2)–NH2 in pharmaceutical building blocks provokes a pressing demand for […]Satenik Mkrtchyan
- Ru(II)-catalyzed direct alkynylation of 2-acylimidazoles with TIPS-alkynes or TIPS-bromoalkynes under air August 11, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00868A, Research ArticleYuting Gui, Xingchi Li, Ting Fu, Taoyuan Liang, Zequan Li, Shuangliang Zhao, Zhuan ZhangA Ru(II)-catalyzed ortho-alkynylation of 2-acylimidazoles is reported, demonstrating compatibility with TIPS-protected terminal alkynes or TIPS-protected bromoalkynes as alkynylating reagents.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Yuting Gui
- A novel class of 1,2,4-diselenazoles obtained via cationic polar cycloaddition between ambiphilic 2-pyridylselenyl reagents and isoselenocyanates exhibiting high antifungal activity August 11, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00927H, Research ArticleAlexander A. Sapronov, Olga G. Chusova, Alexander S. Peregudov, Alexey S. Kubasov, Victor N. Khrustalev, Alexander V. Borisov, Zhanna V. Matsulevich, Evgeny V. Chipinsky, Vladimir K. Osmanov, Rosa M. Gomila, Antonio Frontera, Valentine G. Nenajdenko, Alexander G. TskhovrebovWe report novel class of pyridinium-fused 1,2,4-diselenazoles. Most compounds demonstrated […]Alexander A. Sapronov
- Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls August 25, 2025
