RSC – Org. Chem. Front. latest articles- Recent Advances in Asymmetric C-H Bond Functionalization Enabled by Chiral Directing Groups November 5, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01354B, Review ArticleYun Wang, Shuang Wang, Jiayang Wang, Shao-Jie LouThe asymmetric activation and functionalization of inert C-H bonds represent a central challenge in modern organic synthetic chemistry. Transition-metal-catalyzed strategies have emerged as pivotal solutions for the efficient construction of...The content of this RSS Feed (c) The Royal Society of […]Yun Wang
- BisBF2 pyridoins: A new platform for the design of efficient two-photon absorbers November 4, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01391G, Research ArticlePatryk Rybczyński, Manuela Grelich-Mucha, Elizaveta Petrusevich, Damian Plazuk, Liliana Dobrzańska, Borys Ośmiałowski, Joanna Olesiak-BanskaWe report the synthesis and photophysical studies of quadrupolar dyes based on a new core bearing two BF2 moieties. The photophysical measurements showed the direct vs via-spacer attachment of strong...The content of this RSS […]Patryk Rybczyński
- Computational Investigation of Rh-Catalyzed Three-Component Arylamidation of Alkene: Mechanism, Regio- and Enantioselectivity November 4, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO00998G, Research ArticleJuping Wang, Qifeng Jiang, Peizhi Han, Meng Lu, Tao FengThe Rh-catalyzed three-component arylamidation of allylic sulfides was studied computationally to explore mechanism, regio- and enantioselectivity. In one-pot multicomponent reactions, a significant challenge is that substrate promiscuity promotes com-peting two-component...The content of this RSS Feed (c) The Royal […]Juping Wang
- "Sacrificial reagent" strategy for tailoring adaptive aromaticity in pyrrole rings with its application to singlet fission: a combined DFT and machine learning study November 3, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01255D, Research ArticleQianqian Deng, Sajid Imran, Zijie Qiu, Daigo Miyajima, Jun ZhuAdaptive aromaticity has attracted substantial attention due to its unconventional two-state aromaticity in both the lowest singlet state (S0) and the lowest triplet state (T1) and its application to the...The content of this RSS Feed (c) The Royal […]Qianqian Deng
- syn-Selective carboacylation of terminal alkynes via organic photoredox and nickel catalysis November 3, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01295C, Research ArticleLi-Fang Wang, Chang-Xin Shi, Ming-Jie Xu, Zhe Qi, Tian-Chen Wang, Xian-Hua Pan, Lei GuoA generally mild, efficient, catalytic method for syn-selective intermolecular carboacylation of terminal alkynes via photoredox–Ni dual catalysis is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Li-Fang Wang
- Investigations of Palladium Catalysed 1,1-Aminoacyloxylation of Unsaturated Carboxylic Acids via Experiments and Machine Learning November 1, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01214G, Research ArticleXiangwen Tan, Yinwu Li, Jiahao Wu, Wanqing Wu, Zhuofeng Ke, Huanfeng JiangPalladium catalyzed aza-Wacker oxidation is one of the most effective ways to construct heterocycles. The understanding of the mechanism underlying these approaches facilitate the development of new efficient and practical...The content of this RSS Feed (c) […]Xiangwen Tan
- Enantioselective polar [2σ + 2π] cycloadditions of bicyclo[1.1.0]butanes and ortho-quinone methides enabled by chiral phosphoric acid catalysis November 1, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01029B, Research ArticleLun Xu, Qingwei Zhong, Yalan Zhou, Runqin Liu, Xian Sun, Xiao-Yu Liu, Yong Qin, Hao SongHerein, we report a chiral phosphoric acid-catalyzed enantioselective synthesis of spiro-bicyclo[2.1.1]hexanes featuring vicinal tertiary-quaternary stereocenters. This method employs a formal [2σ + 2π] cycloaddition between bicyclo[1.1.0]butanes and ortho-quinone methides under...The content of […]Lun Xu
- Recent advances in light-enabled deoxygenative transformation of alcohols November 1, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01215E, Review ArticleShiwei Lü, Jie Ding, Zhenda TanAlcohols, serving as fundamental building blocks in organic synthesis, face inherent challenges in deoxygenative functionalization due to the strong chemical inertness of C-O bond characterized by high bond dissociation energy.Recent...The content of this RSS Feed (c) The Royal Society of ChemistryShiwei Lü
- Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with (hetero)cyclic iodonium ylides to access pyrano[4,3-b]pyridin-5one derivatives October 31, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01370D, Research ArticleHailang Cui, Shijin Zhou, Borong Su, Bin Yang, Shaoyu Mai, Huaming TaoWe herein report a Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with iodonium ylides, enabling efficient access to medicinally valuable pyrano [4,3-b]pyridin-5-one derivatives. This external oxidant-free approach demonstrates broad...The content of this RSS Feed (c) […]Hailang Cui
- Lewis Acid Catalyzed Tandem Difunctionalization/Fragmentation Reactions of Bicyclobutanes: Access to 2-Vinylidenyl 1,4-Dicarbonyl Compounds October 31, 2025Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01031D, Research ArticleKun Deng, Xue-Chun Yang, Jian-Jun Feng, Zhaofeng WangStrain-release-driven transformations of bicyclo[1.1.0]butanes (BCBs) have emerged as a highly effective strategy for generating chemical complexity under mild reaction conditions. Herein, we report a tandem ring-opening reaction of acyl BCBs...The content of this RSS Feed (c) The Royal Society of […]Kun Deng
- Enantioselective synthesis of aziridine-fused polycyclic architectures via a catalytic asymmetric aza-Darzens reaction and reductive cyclization October 30, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01362C, Research ArticleZi-Yi Xie, Cong-Lun Xu, Yu Zhu, Jian-Peng Tai, Yang Liu, Hao-Ting Duan, Yi-Jie Jing, Chao-Nan Cheng, Chongqing Pan, Jun XuanA novel protocol to access an aziridine-fused heterotricyclo[4.3.0.02,9]decane framework was developed via a CPA-catalyzed asymmetric aza-Darzens reaction of quinoxalin-2(1H)-ones with diazoacetates, followed by LiAlH4-mediated reductive cyclization.To cite this […]Zi-Yi Xie
- Novel antimicrobial self-assembled cyclic peptide nanotubes containing (1R,3S,4R,5R)-3-amino-4,5-dihydroxycyclohexane-1-carboxylic acid, a new building block for developing mimetics of saccharide–peptide hybrids October 30, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01374G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eva González-Freire, Marcos Vilela-Picos, Verónica Prado, Antonio Pérez-Estévez, Rafael Seoane, Manuel Amorín, Concepción González-Bello, Juan R. GranjaA new class of supramolecular antimicrobials based on D,L-cyclic peptides containing a dihydroxylated-γ-residue, which was designed […]Eva González-Freire
- Photo-catalyzed bis-disulfidation of vinyl arenes with tetrasulfides in aqueous phase October 30, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01389E, Research ArticleYing-Ming Song, Binbin Huang, Yao Xiao, Zi-Shan Liu, Chen Zhang, Hua Cao, Yue YuWe developed a photoredox-catalyzed system for the bis-disulfuration of vinyl arenes in the aqueous phase. The 1,2-bis(disulfidation)ethane products showed great potential for application in cathode materials of lithium-ion batteries.To cite this article before page […]Ying-Ming Song
- [2.2]Paracyclophane–dicyanorhodanine conjugates as planar chiral molecular photoswitches October 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01401H, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Parag Das, Cole D. Stearns, Ion Ghiviriga, Łukasz Dobrzycki, Ronald K. Castellano[2.2]pCp–RCN conjugates are presented as planar chiral photoswitches showing well-controlled Z/E photoisomerization and reversible chiroptical response upon visible-light-irradiation.To cite this article […]Parag Das
- Bis-Guanidinate Magnesium Amide-Catalyzed Hydroboration of Nitriles and Isocyanides via a Non-Hydride Pathway October 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01184A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sayantan Mukhopadhyay, Smrutirani Padhan, Anubhab Das, Sharanappa NembennaThe bis-guanidinate amido magnesium (II) compound [LMgN(SiMe3)2; L = {(ArHN)(ArN)-C=N−C=(NAr)(NHAr); Ar = 2,6-Et2-C6H3] (Mg-1) has been employed as a pre-catalyst for the dihydroboration of nitriles, […]Sayantan Mukhopadhyay
- Cobalt-catalyzed cross-electrophile coupling of aryl bromides and linear secondary alkyl bromides October 23, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01310K, Research ArticleRuobin Wang, Qiang Hu, Jun ZhuAn efficient cobalt-catalyzed cross-electrophile coupling (XEC) reaction of aryl halides with linear secondary alkyl halides to construct C(sp3)–C(aryl) motif was reported. The key to the reaction is the use of a phosphino-oxazoline (PHOX) ligand.To cite this article before page numbers are assigned, […]Ruobin Wang
- cis-Diphosphine Ethene Ligands Enable Ni-Catalyzed Amination of Aryl Chlorides October 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01105A, Research ArticleGuizhi Zhai, Xulu Lv, Xiaoli Li, Yalong Li, Xiaofen Wang, Fengqian Zhao, Junliang WuA class of cis-diphosphine ethene ligands has been designed for the Ni-catalyzed C-N coupling reaction of aryl chlorides. Rigid structure, large steric hindrance and easily adjustable electronic effects are the...The content of this RSS […]Guizhi Zhai
- Photoredox-catalyzed three-component radical coupling of potassium alkyltrifluoroborates, DABSO and polyfluoroarenes October 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01163A, Research ArticleYunliang Guo, Jiuli Xia, Kaixuan Chen, Kehan Jiao, Ying Dong, Guangfan Zheng, Jiao Qu, Jiaqiong Sun, Tao Xiong, Qian ZhangVisible light-driven three-component coupling of RBF4K, DABSO, and polyfluoroarenes through radical–polar crossover mechanisms provides a modular platform for synthesis of polyfluoroarylsulfones.To cite this article before page numbers are […]Yunliang Guo
- Transition metal-free transfer of iodoarenes by organohypervalent iodine compounds October 22, 2025Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01262G, Review ArticleIshita Neogi, Simi Achankunju, Gourab Mohanty, Keshaba Nanda ParidaOrganohypervalent iodine compounds serve as iodoarene precursors. A library of iodoarene end-products with diverse functionalities could be synthesized using these compounds in transition metal-free protocols.To cite this article before page numbers are assigned, use the DOI form of citation […]Ishita Neogi
- Regioselective α-alkylation of benzo-fused cyclic amines via organic photoredox catalysis October 21, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01322D, Research ArticleZiwei Xia, Richang Wen, Chuang Lei, Lelin Zhou, Fuhong Xiao, Jinhui Cai, Guo-Jun Deng, Ya ChenAn organophotoredox catalytic method has been developed for the selective α-alkylation of benzo-fused cyclic amines with alkenes.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Ziwei Xia
- Recent Advances in Asymmetric C-H Bond Functionalization Enabled by Chiral Directing Groups November 5, 2025
