RSC – Org. Chem. Front. latest articles- Conversion of Phenols to Phosphamides and Sulfonamides through a Sequential Dearomative Functionalization followed by Reductive Coupling Strategy July 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00811E, Research ArticleHaripriya Bhumannagari, Nagaraju Rajana, Kiranmai NayaniEfficient and direct conversion of phenols to arylphosphamides and arylsulfonamides has been achieved using a sequential oxidative dearomative functionalization-reductive coupling strategy. The earlier methods involve use of azides or amines...The content of this RSS Feed (c) The Royal Society of ChemistryHaripriya Bhumannagari
- Phosphorus Catalysis Enabling α-sp3-C-H Amination of 2-Alkylpyridines July 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00960J, Research ArticleYoshito Heike, Asa Tagata, Akira Yada, Kanako Nozawa-Kumada, Masaya Sawamura, Yohei ShimizuPhosphorus-catalyzed sp3-C-H amination of 2-alkylpyridines was developed as a notable advancement of a catalytic sp3-C-H functionalization by an organophosphorus compound. Racemic 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) acted as a particularly efficient catalyst precursor...The content of this RSS Feed (c) […]Yoshito Heike
- Exploring the intricacies of inverse hydride shuttle catalysis in azabicyclic scaffold construction with contiguous stereocenters July 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00627A, Research ArticleDamanpreet Kaur, Saurabh Vinod Parmar, Aniket Nigade, Vidya AvasareFrom achiral to chiral: elucidating the reaction mechanism involved in the construction of three contiguous stereocenters in azabicyclic compounds without chiral precursors or catalysts.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Damanpreet Kaur
- Inorganic Reagents in photochemical Reactions July 17, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00888C, Review ArticleZhan-Yong Wang, Ziyan Zhang, Yang Liu, Yumeng Li, Xinyue Dong, Ran XiaInorganic reagents are safe, low-cost, easy to store, and easy to remove after a reaction. These properties make them attractive for direct use in organic synthesis. Inorganic reagents can serve...The content of this RSS Feed (c) […]Zhan-Yong Wang
- Combined Photoredox and Carbene Catalysis: Alkene Borocarbonylation via the Persistent Radical Effect July 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00819K, Research ArticleXiaochen Wang, Senhui Wu, Hongyu Zhang, Qingmin Wang, Shu-Rong BanHerein, we report a mild and operationally simple dual-catalytic method for the synthesis of β-boryl carbonyl compounds via alkene difunctionalization. Specifically, combining N-heterocyclic carbene catalysis and photocatalysis enables a three-component...The content of this RSS Feed (c) The Royal […]Xiaochen Wang
- Construction of Fused BN-Heterocycles via Boron Atom Insertion: DFT Insights into the Lewis Acid-Base (BBr3/NEt3) Cooperative Mechanism and Selectivity July 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00870K, Research ArticleJingxin Hu, Lin Zhang, Zexing CaoThe BBr3-mediated N-heterocycle editing reaction through boron atom insertion strategy reported by Song et al. (Angew. Chem., Int. Ed. 2024, 63, e202318613), has been systematically explored by density functional theory...The content of this RSS Feed (c) The Royal Society of ChemistryJingxin Hu
- Photoredox/Cobalt Dual-Catalyzed Regioselective Hydroalkoxylation of 1,3-Dienes with Alcohols July 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00777A, Research ArticleBei Chen, Zhimeng Song, Yukun Chen, Xingru Yan, Ge Zhang, Qian ZhangCatalytic hydroalkoxylation of alkenes with oxygen-nucleophiles is of great interest and importance but remains an under developing task in synthetic chemistry. Here, we developed a photoredox and Co-catalyzed regioselective hydroalkoxylation...The content of this RSS Feed (c) […]Bei Chen
- One-Pot Cobalt-Catalyzed Ring-Opening of Diaziridines for Bismuth-Promoted Fischer Indole Synthesis July 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00802F, Research ArticleXiao-Lei Zhang, Le Wang, Cheng-Long Wang, Shen-Yuan Zhang, Zi-Hao Li, Shuyu Zhang, Heyuan BaiIndole serves as a privileged scaffold in numerous natural products and pharmaceuticals, with Fischer indole synthesis representing the most widely employed synthetic methodology. In this study, we introduce a cobalt-catalyzed,...The content of this RSS […]Xiao-Lei Zhang
- Terpene cyclization catalysis with a functional cavitand: driving selectivity through precise molecular recognition July 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00922G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ricard López-Coll, Agustí LledóA three-walled self-folding cavitand receptor derived from resorcin[4]arene featuring phenol groups near the confined space catalyzes the cyclization reaction of nerol, using HCl as co-catalyst. In contrast to terpene […]Ricard López-Coll
- Copper-catalyzed synthesis of hydrazone derivatives between oxime esters and azodicarboxylates July 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00775E, Research ArticleHengming Yang, Jiangna Yue, Hongda Xia, Chongchong Ma, Chenjie Lu, Xike Wang, Zhuochen Hu, Zhaoyang Yu, Xia Fan, Rongshun ChenA novel copper-catalyzed reaction of oxime esters with azodicarboxylates is herein described, affording a range of unsymmetrically substituted N-acyl hydrazone derivatives with excellent E selectivity in 31-77% yields. […]Hengming Yang
- Lumiflavine-catalyzed, visible-light-driven allylation of cyclobutanone oximes: a sustainable approach to distally unsaturated nitriles July 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00695C, Research ArticleYanyu Lu, Kaiyu Yan, Yanzhe Shi, Cuiqing Gao, Yitao Zhu, Yinlei Zhang, Teck-Peng Loh, Peizhong XieA naturally derived organophotoredox catalyst system enables the metal-free, stereoselective ring-opening allylation of cyclobutanone O-acetyl oxime esters under mild conditions.To cite this article before page numbers are assigned, use the DOI form […]Yanyu Lu
- Metal- and Base-Free Spirocyclization of Alkylidene Oxindoles via Photo- and Mechanochemically Generated Nitrile Ylides and Nitrile Imines as 1, 3-Dipoles July 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00851D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shweta Singh, Roopam Pandey, Varun Christopher, Mahesh Kumar Ravva, Rakesh Ganguly, Subhabrata SenHerein we have reported an expedient synthesis of spiro[pyrrolidine-3, 3′-oxindole] and 2'-aryl-2',4'-dihydrospiro[indoline-3,3'-pyrazol]-2-one under metal and base free conditions through the […]Shweta Singh
- B(C6F5)3-catalyzed TMSOTf-assisted intermolecular redox-neutral cyclization of N,N-dialkyl arylamines and allylic esters July 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00863H, Research ArticleQin-Long Wang, Wen-Jing Wang, Shuo Peng, Cuifen Lu, Junqi Nie, Sheng-Chao Huang, Chao MaHere，we present an unprecedented intermolecular redox-neutral cyclization of tertiary anilines and allylic esters to deliver a wide range of substituted tetrahyroquinolines in high efficiency. This one-pot strategy is initiated by...The content of this RSS […]Qin-Long Wang
- Countercation- and solvent-controlled selective borohydride hydrogenation of alkenes in diaryl enones July 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00883B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Miguel Espinosa, Miquel Molina-García, Daniel Ciscares-Velázquez, Antonio Leyva-PérezGem-diaryl enones and trans-diaryl enones (chalcones) are selectively hydrogenated at the alkene rather than at the ketone functionality under standard uncatalyzed reaction conditions with metal […]Miguel Espinosa
- Synthesis of 1,1-bis(indolyl)alkenes via nickel-catalyzed selective alkynylation of indoles with haloalkynes July 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00787A, Research ArticleShuqi Guo, Xinni Qiu, Huanfeng Jiang, Shaorong Yang, Wanqing WuA novel nickel-catalyzed cascade alkynylation and nucleophilic addition of indoles with haloalkynes to synthesize 1,1-bis(indolyl)alkenes has been accomplished.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Shuqi Guo
- DFT study of nickel-catalyzed regio- and enantioselective hydroalkoxylation of 1,3-dienes with methanol: inner-sphere versus outer-sphere mechanisms July 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00814J, Research ArticleXia Zhao, Yong Xia, Xiaotai WangComputational analysis, guided by the Curtin–Hammett principle, elucidates the mechanism of a Ni-catalyzed regio- and enantioselective hydroalkoxylation of 1,3-dienes with methanol, revealing novel insights into C–O bond formation.To cite this article before page numbers are assigned, use the DOI form of citation […]Xia Zhao
- Dynamic clipping strategy to synthesize [2]rotaxanes consisting of borate ion-containing crown ether and ammonium ions with kinetic and thermodynamic control July 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00880H, Research ArticleTakumi Takizawa, Shinobu Miyagawa, Yuji TokunagaRotaxanes consisting of borate crown and ammonium ions were synthesized using a dynamic clipping approach. In competitive rotaxane-forming reaction involving two amines, each rotaxane is selectively formed under kinetic and thermodynamic conditions.To cite this article before page numbers are assigned, use the […]Takumi Takizawa
- Multistage Organic Redox Systems. Aromaticity as a Guiding Principle for Materials Chemistry July 9, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00746A, Review ArticleMarcin Stępień, Ishfaq Ahmad Bhat, Ankit Kumar Gaur, Natasza SpruttaOrganic π-conjugated molecules capable of undergoing multistage redox processes have emerged as versatile platforms for applications in energy storage, molecular electronics, and optical devices. This review highlights the critical role...The content of this RSS Feed (c) The Royal […]Marcin Stępień
- Triple C–F bond functionalization via an orderly elimination–oxidation–substitution relay reaction July 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00864F, Research ArticleXiongda Xie, Haoran Xu, Lixin Qian, Gang Chen, Yufei Zhang, Hui Miao, Kewei Chen, Xiao-Song Xue, Xinfang XuA comovement group strategy is presented, which enables an orderly triple C–F bond functionalization process, providing practical access to α-ketoamides from readily available reagents by using water and oxygen in […]Xiongda Xie
- A general rhodium-catalyzed regioselective C–H functionalization: accessing heteroarylated and alkenylated arenes July 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00647C, Research ArticleTian Cao, Yan Wang, Shiping Zhan, Wenqian Ding, Xiaowei WuAn efficient rhodium-catalyzed C–H heteroarylation and alkenylation of pyridotriazoles and ortho-aryl heterocycles with iodonium ylides is reported. This strategy enables the synthesis of heteroarylated and alkenylated heterocycles and arenes.To cite this article before page numbers are assigned, use […]Tian Cao
- Conversion of Phenols to Phosphamides and Sulfonamides through a Sequential Dearomative Functionalization followed by Reductive Coupling Strategy July 18, 2025
