RSC – Org. Chem. Front. latest articles- Theoretical Insight into the Mechanism, Selectivity, and Substituent Effects in Rh-Catalyzed Asymmetric Arylation of Cyclobutenone Ketals with Arylboronic Acids March 12, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00087H, Research ArticleJinZhao Wang, qiang zhang, Li Jiang, Rong-Xiu Zhu, Dongju ZhangDFT calculations were conducted to elucidate the reaction mechanism, the origin of selectivities, and substituent effects in the rhodium-catalyzed asymmetric arylation of cyclobutenone ketals with arylboronic acids. The results reveal...The content of this RSS Feed (c) The Royal […]JinZhao Wang
- Reaction Profiling of Visible Light-Mediated [2+1] Dearomatization vs Alkylation of Electron-Rich Arenes with Aryldiazoacetates: Real-Time NMR Monitoring, Kinetics, and Computational Analysis March 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00072J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Karlo Petrić, Ana Čikoš, Ivana Nikšić-Franjić, Guy C. Lloyd-Jones, Matija Gredičak, Nikola TopolovcanDearomative [2+1] reaction between electron-rich arenes and aryldiazoesters for the regioselective and diastereoselective synthesis of norcaradienes is reported. Strategic tuning […]Karlo Petrić
- Ligand-Enabled Hydrohydrazidation of Alkynes Catalyzed by Unsymmetrical Gold(I)-Thiazol-2-ylidenes March 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01755F, Research ArticleShidi Ma, Jin Zhang, Yawei Zhu, Sijie Zhou, Li Sun, Jianglong Cai, Weixi Yang, Michal SzostakAcyl hydrazines represent a privileged class of amide derivatives in organic synthesis and drug discovery, however, methods for effecting site-selective hydrohydrazidation remain underdeveloped. Herein, we report highly selective Au(I)-NHC catalyzed...The content of […]Shidi Ma
- Palladium-Catalyzed Hydrofunctionalization Cyclization of 1,3-Enynes to Access Cyclopenta[b]indoles March 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00090H, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zonglin Ma, Xihang Lu, Hequan Yao, Aijun LinWe herein present a palladium-catalyzed sequential hydroarylation and hydroalkylation of readily available 1,3-enynes with indole-2-malonates. This redox-neutral strategy provides a facile, atom and step-economical route […]Zonglin Ma
- Alkali/alkaline earth metal-mediated mechanochemical Wurtz reactions March 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00142D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yoshifumi Toyama, Hideto ItoThe Wurtz reaction is a classical C(sp3)–C(sp3) bond-forming reaction involving alkyl halides and alkali metals. However, this reaction generally requires molten or dispersed metals in large amounts of solvent, […]Yoshifumi Toyama
- High-throughput screening and machine learning prediction of Rh-catalyzed ortho-C(sp2)–H amidation of arylaldehyde hydrazones March 6, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00026F, Research ArticleYan Zhang, An Lin, Cuitong Zhou, Jingyuan Liu, Yahuan Wang, Xinwei Zhu, Lebin Su, Kuangbiao LiaoA high-throughput, machine learning-assisted protocol enables efficient Rh-catalyzed ortho-C(sp2)–H amidation of arylaldehyde hydrazones with dioxazolones.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Yan Zhang
- Electronic Modification of Hexa-2,4-diyne-1,6-diols: Predictive Access to Strained Cyclobutenes and 3(2H)-Furanones March 5, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00056H, Research ArticleSeyed Mohammad-Bagher-Hosseini Ghazvini, Diego Cordova, Ingrid Dell, Elena Dallerba, Carol Hua, Paul Low, Massimiliano Massi, Marcus KorbThe acid-mediated activation of hexa-2,4-diyne-1,6-diols (1) is the standard protocol for the formation of valuable strained 1,2-dihalocyclobutenes/1,2-dihalobutafulvenes (3). However, the reaction is sluggish, associated with poor yields caused by formation...The content […]Seyed Mohammad-Bagher-Hosseini Ghazvini
- Unveiling the mechanisms of gold/copper bimetallic catalysis in the synthesis of complex heterocyclic compounds March 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01639H, Research ArticleFengjuan Ma, Qing Sun, Jingxin Hu, Xin Cheng, Huiwen Zheng, Lei Zhou, Xin Lu, Yidong Luo, Ren-Jie SongBimetallic catalysis offers enhanced reactivity, selectivity, and cooperative effects compared to traditional monometallic catalysis. However, the detailed understanding of coordination and metal interactions in such bimetallic systems is still elusive....The […]Fengjuan Ma
- A Divergent Electrochemical Platform for Diazene Radical Generation and C–N Coupling Reactions March 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00078A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Roopam Pandey, Suchismita Rath, Yashika Tyagi, Shivani Jadoni, Tejas Prabakar, Shreemad Patel, Debajit Maiti, Subhabrata SenThe development of sustainable methods for controlled C-N bond formation remains a central challenge in modern synthesis. […]Roopam Pandey
- A copper-catalyzed B–H bond insertion reaction of triboranes (L·B3H7) with diazo compounds March 3, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00098C, Research ArticleLei Cao, Jia-Rui Chang, Xi-Meng Chen, Yan-Na Ma, Xuenian ChenA copper-catalyzed protocol for regioselective B–H bond insertion of triborane with diazo compounds provides a versatile route to functionalized organoboranes and boron-stereogenic centers, and potential applications in 10B-labeled drugs for BNCT.To cite this article before page numbers are […]Lei Cao
- Tunable ring-opening of 2H-azirines via visible-light-driven novel selective C–C/C–N or CN bond cleavage March 3, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00168H, Research ArticleBao-Gui Cai, Li-Hua Zhang, Yang Xie, Qiong Zhang, Jun XuanA catalyst-free, visible-light-induced annulation of 2H-azirines and hydrazonyl chlorides via EDA activation affords 1,3,5-triazines or imidazoles. The 2H-azirine substitution pattern controls reactivity, giving a practical route to N-heterocycles.To cite this article before page numbers are assigned, use the […]Bao-Gui Cai
- Site-selective iron-catalyzed C–H alkylation of pyrazinones, azauracils and quinoxalinones March 3, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00044D, Research ArticleVaibhav Ramchandra Pansare, Sreelakshmi N, Nagaraju BarsuDescribed herein is an unprecedented iron-catalyzed C(sp2)–H alkylation of pyrazinone, azauracil, and quinoxalinone analogues using ethers and benzyl derivatives, offering broad scope and high functional group tolerance.To cite this article before page numbers are assigned, use the DOI form of citation […]Vaibhav Ramchandra Pansare
- Photocatalyzed regioselective arylation of trialkylamines March 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01719J, Research ArticleJiamin Wu, Xin Wang, Kuai Wang, Ling-Guo MengEasily available trialkylamines are increasingly utilized as coupling partners with diverse hydrocarbons to construct various complicated amine frameworks. However, controlling the regioselectivity of these reactions remains a significant challenge. We...The content of this RSS Feed (c) The Royal Society of […]Jiamin Wu
- Cu(I)-catalyzed 1,2-carbofluorination of unactivated alkenes enabled by N-fluorobenzamides via free radical relay March 2, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01763G, Research ArticleHong Ji, Haifeng Qiao, Boyi Wang, Tianyu Lu, Weixing Chang, Lingyan Liu, Jing LiWith N-fluorobenzamide as carbofluorine-bifunctional reagent, 1,2-carbofluorination of unactivated alkenes via radical-relay gives complete atom economy and various long-chain fluorinated compounds in moderate to good yields.To cite this article before page numbers are assigned, use the […]Hong Ji
- Halogen Atom Transfer-Induced Radical Cascades Cyclization of N-(o-Cyanobiaryl)acrylamides with Alkyl Halides via Boryl Radical-Mediated March 2, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01481F, Research ArticleLong-Jin Zhong, Xuan Shang, Pengfei Huang, Quan Zhou, Changhui Liu, Yu LiuWe report a study on the use of ligated boryl radicals for the synthesis of nitrogen-containing polycyclic compounds under photocatalytic conditions through a halogen-atom transfer (XAT) strategy. This approach leverages...The content of this RSS Feed (c) […]Long-Jin Zhong
- EtAlCl2-promoted defluorinative thiolation of α-trifluoromethyl alkenes March 2, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00011H, Research ArticleXin Guo, Guoliang Pu, Long Xiao, Jiarui Liang, Hang Zhang, Yu Chen, Yang Huang, Qiuli Yao, Chun-Yang HeA method for the EtAlCl2-promoted thiolation of trifluoromethyl alkenes has been developed, achieving complete defluorination to yield trisubstituted alkenes.To cite this article before page numbers are assigned, use the DOI […]Xin Guo
- Engineering tetraphenylethene-based Z and E stereoisomers: structural analysis and sensing applications February 28, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00075D, Research ArticleHan-Jiang Yang, Yatuan Ma, Xinpei Zhong, Xin Yang, You Xu, Xiaoxue Zhang, Zhixin Xiang, Xiujuan Huang, Wenji Wang, Jinyi Wang, Mao-Sen YuanThis work extends the family of stereoisomers available in molecular engineering with new structures and correlated morphologies and functionalities and demonstrates the design, separation and differentiation […]Han-Jiang Yang
- Oxidation Reactions in the Current Total Synthesis of Natural Products February 27, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00050A, Review ArticleJian-Feng Zheng, Anqi Chen, Yan-Jiao Gao, Pei-Qiang HuangOxidation and oxidative reactions are a type of fundamental transformation in organic chemistry, which are indispensable for organic synthesis, especially for the total synthesis of natural products. Although there are...The content of this RSS Feed (c) The Royal Society of […]Jian-Feng Zheng
- Polysubstituted bicyclo-[2.1.1]-hexanes as benzene isosteres for medicinal chemistry February 27, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01662B, Review ArticleEugenio Roà, Quentin LefebvreThis comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Eugenio Roà
- Interactions beyond H-bonding: unveiling the role of unorthodox noncovalent interactions in charged thiourea and its catalytic efficiency February 26, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D5QO01735A, Research ArticlePrabhahar Murugan, Parul Rathour, Dipankar Das, Brijesh Patel, Srinu Tothadi, Bishwajit Ganguly, Saravanan SubramanianClassic scaffold with new identity: We report the functional modification of thiourea moiety via the charge incorporation that enhances its acidity and imparts beneficial non-covalent interactions, leading to an efficient catalyst.To cite this article […]Prabhahar Murugan
- Theoretical Insight into the Mechanism, Selectivity, and Substituent Effects in Rh-Catalyzed Asymmetric Arylation of Cyclobutenone Ketals with Arylboronic Acids March 12, 2026
