RSC – Org. Chem. Front. latest articles- One-pot synthesis of pyrimido[1,2-a]benzimidazoles using calcium carbide as an acetylene source June 14, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00446F, Research ArticleCuimei Liu, Rui An, Peiming Gu, Meng-Xue WeiA highly pot-, atom-, and step-economical strategy for the synthesis of pyrimido[1,2-a]benzimidazoles exhibiting strong yellow photoluminescence.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Cuimei Liu
- Radical cyclization via selective C–X bond transformation June 11, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00445H, Review ArticleHong-Lin Wu, Jie-Xi Guo, Cuiyan Wu, Ya-Ge Zheng, Jun-Qi Liu, Shi-Qing Zhang, Jia-Wei Wu, Wei Yang, Wen-Ting WeiThis review systematically summarizes recent advances in four radical activation pathways for carbon-halogen bonds: Direct C–X bond homolysis, PET, SET, and XAT, covering their reaction mechanisms, catalytic systems, and substrate […]Hong-Lin Wu
- Photoinduced Asymmetric Cross-Couplings via a Radical Brook Rearrangement June 11, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00624H, Research ArticleSongwei Wen, Danhua QianPhotocatalytic asymmetric cross-coupling of aryl bromides with organosilicon reagents bearing an α-hydroxyalkyl group has been achieved via a dual catalysis strategy. The use of a benzophenone derivative that allows PCET...The content of this RSS Feed (c) The Royal Society of ChemistrySongwei Wen
- Thioxanthone modified flavin for photo-decarboxylation of aromatic acids to enable C-2 arylation of nitrogen heterocycles June 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00493H, Research ArticleYuying Gu, Hao Wang, Yao Zhao, Yu Zhang, Houhai Fan, Xiliang Xu, Weiwei Zhang, Xianbo Du, Wenyi ChuVisible-light-induced decarboxylation of aryl carboxylic acids has become a promising for the generation of aryl radical precursors. Due to the inherent limitations of traditional photosensitizers, the application of this strategy...The […]Yuying Gu
- Transition metal-catalyzed monodentate directing group-assisted C–H functionalization: an overview of advances (2015–2024) June 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00602G, Review ArticleLei Wang, Fei Yao, Pu-Fan Qian, Xin-Shang Hui, Bing-Jie Wang, Jun-Yi Li, Ming-Ya Teng, Tian-Yu Jiang, Ke-Xin Kong, Chen-Yue Wang, Zi-Jia Chen, Yao-Le Jiang, Yan-Xuan Wu, Ao-Lian Jiang, Boyang Jiang, Yi-Jie Gao, Liu De-Yang, Jia-Heng Hu, Qi-Jun Yao, Tao Zhou, Bing-Feng ShiTransition-metal-catalyzed directed C–H activation provides an […]Lei Wang
- Solvent Controlled Regioselective Iodocyclization of Propargylic Amides June 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00517A, Research ArticleHuilin Zhan, Run Yu, Shuxuan Liu, Zhengyu Han, Hai HuangThe development of controllable reactions, due to their particularity of generating diverse products from a single starting material, has long been an important research area in organic synthesis. In this...The content of this RSS Feed (c) The Royal […]Huilin Zhan
- Theoretical Insights into the Mechanism and Ligand-Controlled Chemoselectivity of Multicomponent Carbonylation toward γ-Butenolide and Ynone June 10, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00634E, Research ArticleGuanghui Song, Wen Zeng, Yanting Lan, Xuande Su, Juan LiPalladium-catalyzed multicomponent carbonylation reactions provide an efficient platform for the ligand-controlled, switchable synthesis of structurally diverse carbonyl compounds. However, the intrinsic complexity of these multicomponent catalytic systems, particularly the origin...The content of this RSS Feed (c) The Royal […]Guanghui Song
- Advances in Synthesis of the Chiral Benzo-Fused N-Heterocycles June 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00466K, Review ArticleKhuzaifa Muhammad, Irsa Kainat, Qingle ZengChiral benzo-fused N-heterocycles are common in natural products, drugs, and materials. Over the last twenty years, their asymmetric synthesis has evolved from stoichiometric chiral-pool methods to advanced catalytic techniques that...The content of this RSS Feed (c) The Royal Society of ChemistryKhuzaifa Muhammad
- Supramolecular modulation of π-extended pyridinium photosensitizers for enhanced dual reactive oxygen species photocatalysis June 9, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00592F, Research ArticleYusong Bi, Man Jiang, Wen-Qiang Liu, Ling-Bao XingThe efficient and simultaneous generation of multiple reactive oxygen species (ROS) by a single photosensitizer under mild and environmentally benign conditions remains challenging. Herein, we present a supramolecular host-guest approach...The content of this RSS Feed (c) The Royal Society of […]Yusong Bi
- High-throughput hydrogen isotope exchange via transfer deuteration June 8, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00301J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anika Schick, Christoph Bauer, Tove Slagbrand, Michael Guerzoni, Maria Johansson, Sahil Gahlawat, Magnus Johansson, Per-Ola Norrby, Charles S. Elmore, Markus ArtelsmairWe developed a rapid screening protocol based on transfer deuteration using formic […]Anika Schick
- Unlocking XAT/HAT selectivity: a machine learning-guided discovery of governing physicochemical principles June 8, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00596A, Research ArticleSiqi Liu, Wenqiang Xu, Tian-Yu Sun, Longjie Huang, Yun-Dong Wu, Xinhao ZhangMachine learning couples with DFT calculations to unlock the governing principles of HAT/XAT selectivity, establishing a robust predictive platform for physical organic chemistry.To cite this article before page numbers are assigned, use the DOI form of […]Siqi Liu
- Physical organic origin of ligand-controlled β/γ-regiodivergence in NiH-catalyzed hydroalkylation June 8, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00581K, Research ArticleSimeng Qi, Ran Fang, Lizi YangLigand-controlled NiH hydroalkylation: β/γ regiodivergence arises from competition between chain walking and radical rebound. DFT shows ligand-dependent spin-state access and β-H elimination govern selectivity, enabling descriptor-guided design.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Simeng Qi
- Chemo- and stereoselective Rh(III)-catalyzed coupling of indoles with CF3-imidoyl sulfoxonium ylides via thioamide-directed C–H activation June 8, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00532B, Research ArticleHongliang Wu, Ruirui Zhai, Liming Zhou, Siyu Chang, Guiwei Yao, Chen Li, Fengjuan Chen, Dulin Kong, Xun ChenA thioamide-directed, Rh(III)-catalyzed divergent coupling of indoles with CF3-imidoyl sulfoxonium ylides is developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Hongliang Wu
- Cycloaddition/Ring-Opening Cascade Reaction of Alkylidene Azlactones for the Synthesis of α,α-Disubstituted α-Amino Acid Esters June 7, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00556J, Research ArticleJyoti Sikarwar, Jyoti Chauhan, Rama Krishna PeddintiA metal-free, one-pot cascade reaction between alkylidene azlactones and N-phenacylbenzothiazolium salts, enabling efficient access to pyrrolo[2,1-b]benzothiazole-based amino acid esters. This solvent-controlled [3+2] annulation and methanol-triggered azlactone ring-opening constructs two C–C...The content of this RSS Feed (c) The Royal Society of ChemistryJyoti Sikarwar
- Twofold 4-to-6 ring expansion of azetines to bis-halogenated pyridines June 7, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00502K, Research ArticleRahma Ghazali, Elias Schick, Stefan Immel, Dorian DidierA sequence of two consecutive skeletal editing steps through carbon insertions has been developed and allows the regioselective ring expansion of functionalized 2H-azetines to 3,5-bis-halogenated pyridines.To cite this article before page numbers are assigned, use the DOI form of citation […]Rahma Ghazali
- Manganese(I)–CNP complex-catalyzed multicomponent synthesis of 2-pyrazolines by acceptorless alcohol dehydrogenation June 7, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00513F, Research ArticleXiaohui Zhu, Jiangui Zhao, Hua Chen, Xueli Zheng, Haiyan Fu, Weichao Xue, Ruixiang LiThis study disclosed an efficient multicomponent cascade reaction for the synthesis of structurally diverse 2-pyrazolines through inexpensive first-row manganese(I) complex-mediated acceptorless alcohol dehydrogenation.To cite this article before page numbers are assigned, use the DOI […]Xiaohui Zhu
- Redox-neutral electrochemical diazo coupling: controlled synthesis of olefins and azines via modulating reaction conditions June 5, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00499G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abinash Mohapatra, Vikas TyagiWe report a metal-free, linear paired redox-neutral electrochemical diazo coupling that enables the controllable synthesis of olefins and azines by modulating reaction conditions.To cite this article before page numbers […]Abinash Mohapatra
- One stone, two birds: diverse glycopeptide synthesis via radical Ullmann coupling from serine June 5, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00586A, Research ArticleShuang Wang, Qiuju Zhong, Xinru Liang, Gaoqiang Li, Mingyu YangHerein, we reports a two-in-one strategy to streamline glycopeptide synthesis by sequentially modifying identical peptide precursors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Shuang Wang
- Remote Asymmetric amination of Naphthalene-Blocked Alkynes with various amines June 4, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00609D, Research ArticleShi-Wu Li, Su XieIn this study, we rationally designed and successfully established a versatile copper-catalyzed divergent reaction system by employing alkynyl naphthalates as key substrates. This tunable catalytic strategy exhibits distinct and controllable...The content of this RSS Feed (c) The Royal Society of ChemistryShi-Wu Li
- Three-component synthesis of β-phostams June 4, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00590J, Research ArticleWenlong Tong, Chengzhuo Wang, Mengyao Zhang, Jiaxi XuVarious β-phosphinolactams (β-phostams) are directly synthesized from readily available diarylmethylphosphonochloridates, cinnamaldehydes, and lithium hexamethyldisilylamide via the [2 + 2] annulation of imines and phosphenes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Wenlong Tong
- One-pot synthesis of pyrimido[1,2-a]benzimidazoles using calcium carbide as an acetylene source June 14, 2026
