RSC – Org. Chem. Front. latest articles- Aromatization-driven intramolecular 1,5-hydride transfer reductive amination June 28, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00632A, Research ArticleWenquan Wang, Yu He, Jinhui YangAn aromatization-driven intramolecular 1,5-hydride transfer reductive amination for the synthesis of N-benzyl-2-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline derivatives has been established.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryWenquan Wang
- Metal-Free Photocatalytic Alkylation Using Alkylboronic Pinacol Esters June 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00418K, Research ArticleDingyi Wang, Cong Wu, Lujing NiuThis study describes an environmentally friendly, visible-light-driven catalytic strategy that generates carbon radicals from alkyl boronates under metal-free conditions, thereby circumventing the cost and toxicity issues associated with traditional methods....The content of this RSS Feed (c) The Royal Society of ChemistryDingyi Wang
- Electrophile-Triggered Dearomatization of Indolylethylhydroxamic Acids for the Synthesis of Spiro[indole-3,2'-pyrrolidine] derivatives June 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00626D, Research ArticleYeyao Yeyao Li, zhao fengyuan, Tianli Gao, Gao Yuting, Bo Han, Ruili Guo, Haojie Ma, Ji-Jiang Wang, Yuqi Zhang, Zhiqiang RenA dearomatization of indolylethylhydroxamic acids for the synthesis of spiro[indole-3,2'-pyrrolidine] derivatives have been developed for the first time. This method features mild reaction conditions, excellent yields, and […]Yeyao Yeyao Li
- Difluorocarbene-enabled N-deuteroformylation of amines and sulfonamides: access to formamide-1-d and N-CH2D motifs June 28, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00639F, Research ArticleSandeep Kumawat, Kallakuri Leela Manikya Naga Siva Jyothi, Venkata Narayana Kalevaru, Kotha Middela Rahul Reddy, Thota Munikrishna Teja, V. Pratap Reddy Gajulapalli, Sebastian Wohlrab, Kishore NatteA straightforward protocol for the deuteroformylation of complex amines and sulfonamides using BrCF2CO2K and D2O is described, providing versatile N-C(=O)D intermediates for […]Sandeep Kumawat
- Copper-Catalyzed Remote η-Aminoalkylation of 4-Yne-Naphthalene Esters with Amines June 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00672H, Research ArticleHuanshi Wang, Guangyuan Shi, Jiaqi Pu, Shi-Wu LiA copper-catalyzed asymmetric remote η-aminoalkylation of 4-yne-naphthalene esters with various amines is reported. This transformation represents the first example of amination of propargylic substrates spaced by a naphthalene ring. A...The content of this RSS Feed (c) The Royal Society of […]Huanshi Wang
- Benzophenone-mediated deconstructive cross-coupling of secondary alcohols with data-driven mechanistic insights June 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00813E, Research ArticleKodai Takayama, Naoki Noto, Susumu Saito, Takamitsu Hosoya, Yuto SumidaWe report a Ni-catalyzed deconstructive cross-coupling of secondary alcohols under photochemical conditions using a benzophenone-derived organic photocatalyst. The reaction provides access to alkyl radicals from electron-rich benzylic alcohols and enables...The content of this RSS Feed (c) The Royal […]Kodai Takayama
- Recent Advances in Light-Mediated Dearomative Fun ctionalization of Naphthalene and Its Derivatives June 28, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00701E, Review ArticleQuan Wang, Bin Feng, Jiahong LiPhotocatalysis, with its mild conditions, excited state mechanisms, and precise site selectivity, has emerged as a key technology for the dearomatization of fused polycyclic arenes. Naphthalene exhibits intrinsic differences in...The content of this RSS Feed (c) The Royal Society of ChemistryQuan Wang
- A General Photocatalytic Strategy for Allylic C(sp3)–H Functionalization with Nucleophiles using Cyclohexyl Radical as a Hydrogen Atom Abstractor June 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO00991J, Research ArticleQinhui Qinhui Chen, Yigao Tao, Rong HuThe selective transformation of hydrocarbons has become an exceedingly difficult challenge, especially in a stereo-selective manner. Despite remarkable progress, the simultaneous achievement of strong bond activation and versatile functionalization with...The content of this RSS Feed (c) The Royal Society of ChemistryQinhui Qinhui Chen
- Long Visible-Light-Driven Bilin-Based Rotary Molecular Systems: from batch to microfluidics techniques June 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00273K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lidia Hortigüela, Juan Antonio Garcia-Romero, Jose Justicia, Antonio J. Mota, Fátima Fernández-Álvarez, Ana M. Garcia, Araceli G. Campaña, Victor Blanco, Maria Victoria Gomez, Sara P. MorcilloExpanding the library of visible-light-driven rotary molecular […]Lidia Hortigüela
- Nickel-catalyzed annulation of strained cyclic allene and benzodicarboxylic anhydride June 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00720A, Research ArticleGuo Yifeng, Zijun Zhou, Lei Cui, Peng Xu, Xinyao Li, Jian LiStrained cyclic allenes represent a class of in situ-generated transient intermediates with considerable ring strain and high chemical reactivity. These species are advantageous building blocks for the synthesis of complex...The content of this RSS Feed (c) […]Guo Yifeng
- Cobalt-Catalyzed Aerobic Intramolecular Hydroarylation of Allylic Alcohols via Hydrogen Atom Transfer and 1,2-Aryl Migration in HFIP June 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00689B, Research ArticleXiao-Qing Xie, Chen-Jin Rao, Zi-Qiong Li, Chaozhihui Cheng, Lin Lu, Xian-Rong Song, Mu-Jia Luo, Qiang XiaoAryl migration represents a powerful strategy for the selective reconstruction of carbon-skeleton with high atom- and step-economy. Herein, an efficient cobalt-catalyzed 1,2-aryl migration for the intramolecular hydroarylation of allylic alcohols...The content of […]Xiao-Qing Xie
- Tandem catalytic Wittig reaction prepared isocoumarins: New family with tunable multi-stimuli-responsive fluorescence and bioactivity via halogen engineering June 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00408C, Research ArticleMei Sun, Jie Zhou, Qiaoqiao Jia, Xiaogang Zhang, Wenya Song, Kai Chen, Cuie Shi, Jiaxin Hong, Chongyang Zeng, Mingwu DingTo address the limitations of current stimuli-responsive fluorophores in precision medicine and elucidate the role of halogen atoms, a novel family of isocoumarins (ICP-X) featuring both multi-stimuli-responsiveness and […]Mei Sun
- Base-Mediated Double Defluorination and Bisthiolation of α-Trifluoromethyl Alkenes toward Monofluoroalkenes June 26, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00557H, Research ArticleXin Guo, Hang Zhang, Long Xiao, Jiarui Liang, Guoliang Pu, Peng Guo, Jilin Wen, Jia Jia, Chun-Yang HeMonofluoroalkenes are valuable mimics of enol and amide bonds, making them pivotal in drug discovery. Here, we report a transition-metal-free defluorinative bisthioetherification of α-trifluoromethyl alkenes using thiols as the sulfur...The […]Xin Guo
- Enantioselective Diastereodivergent Reactions between Aldehydes and Bicyclo[1.1.0]butanes June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00662K, Research ArticleChengzhuo Wang, Shi Cheng, Zhidong Zhang, Liu Li, Ning Chen, Zhanhui Yang, Jiaxi XuDeveloping diastereodivergent and enantioselective catalytic reactions to access structurally and stereogenically diverse molecules from identical starting materials remains a central challenge in organic synthesis. Optically active three-dimensional saturated oxabicyclo[2.1.1]hexanes (oxaBCHs)...The content of this RSS […]Chengzhuo Wang
- Synthesis of Rigid-Flexible Chiral Borinic Acids and Application in Desymmetrization of Diols June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00673F, Research ArticleShan-SHan Xun, Gao-Wei Wang, Muwang Chen, Yong-Gui Zhou, Sheng-Mei LuDespite recent progress achieved in the development and application of chiral organoboron acid catalysts, the efficient chiral catalysts remain scarce due to the inferior stereocontrol arising from planar geometry of...The content of this RSS Feed (c) The Royal […]Shan-SHan Xun
- Unravelling the Assembly Pathways of Hydrogen-Bonded Amide-based [2]Rotaxanes: a Computational and Experimental Study June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00724D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel Hernandez-Hidalgo, Jose Manuel Garcia-Romera, Marta Marin-Luna, Alberto Martinez-Cuezva, Jose BernaThe assembly mechanism of hydrogen-bonded tetraamide-based [2]rotaxanes is studied through a combined computational and experimental approach. Two possible pathways, involving U-shaped and […]Daniel Hernandez-Hidalgo
- Enantioselective Cyanation-Brook Rearrangement-Protonation of Acylsilanes and Stereospecific Inversion in Brook Rearrangements Generating α-Nitrile Carbanion Equivalents June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00669H, Research ArticleMichiko Sasaki, Kei TakedaThe stereochemical course of Brook rearrangements that generate formal α-nitrile carbanion equivalents remains difficult to define because the resulting anionic species are intrinsically configurationally labile. Here we report two complementary...The content of this RSS Feed (c) The Royal Society of ChemistryMichiko Sasaki
- C-H functionalization reactions of heterocycles with alkyl halides via halogen atom transfer June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00654J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sudip Senapati, Anindya Das, Lilia Weizel, Daniel Merk, Ewgenij Proschak, Sandip Murarka, Rene M KoenigsDirect C-H alkylation of heterocycles is a fundamentally important strategy for the late-stage diversification of natural products and […]Sudip Senapati
- Dearomative 1,6-Difunctionalization of Styrenes via Photoredox Palladium Catalysis June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00706F, Research ArticleXin-Han Wang, Xin-He Han, Chun-Lin Zhang, Song YeAn efficient dearomative 1,6-difunctionalization of styrenes was developed via photoredox palladium catalysis, giving the corresponding alkylidenecyclohexadienes in moderate to good yields. Axially chiral alkylidenecyclohexadienes was obtained with promising enantioselectivity when...The content of this RSS Feed (c) The Royal Society of […]Xin-Han Wang
- Photoelectrochemical hydroxymethylation and cyclization of N-aryl-2-CF3-acrylamides with TMSCH2OH June 25, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00697C, Research ArticleLei Wang, Zhong-Wei Hou, Fei-Fei Xu, Quan ZhouAn organocatalyzed photoelectrochemical approach for the radical-mediated hydroxymethylation and cyclization of N-aryl-2-CF3-acrylamides with (trimethylsilyl)methanol (TMSCH2OH) has been developed. This reaction employs 2chloroanthraquinone (2-Cl-AQ) as the organocatalyst and TMSCH2OH as the...The content of this RSS Feed (c) The Royal Society of […]Lei Wang
- Aromatization-driven intramolecular 1,5-hydride transfer reductive amination June 28, 2026
