RSC – RSC Chem. Biol. latest articles- New Insights into the Structure and Dynamics of the Epigenetic Modifications on DNA October 12, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00207A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dineshbabu Takkella, Javier Cerezo, Lara Martinez-Fernandez, Krishna GavvalaDNA methylation is a key epigenetic modification involved in genomic imprinting, Xchromosome inactivation, and repression of repetitive element transcription and transposition.Despite its biological significance, the impact […]Dineshbabu Takkella
- Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan October 9, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00187K, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lloyd Declan Murphy, Saeed Akkad, Angelo Lopez, Morgan Batiste-Simms, Greg Laughlan McNeil, Eva Wu-Di Wan, Kathryn Huxley, Luke Julyan, Mia Shandell, Lianne WillemsThe glycoprotein α-dystroglycan is essential in establishing cell-matrix interactions and is […]Lloyd Declan Murphy
- Chemically Inducible Antisense Oligonucleotides for Cell-Specific Gene Silencing October 8, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00186B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zhen Xun, Yang Hai, Lijuan Tang, Jian-Hui Jiang, Zhenkun WuThe ability of cell-specific control of the function of antisense oligonucleotides (ASO) is highly desirable for precise gene therapy with minimizing adverse effect in […]Zhen Xun
- A disubstituted aniline probe for enhanced peroxidase-based proximal protein labelling October 7, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00095E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pornchai Kaewsapsak, Nattavorapon Tantisasirat, Sucheewin Krobthong, Peeraphan Compiro, Ariya Khamwut, Kidakarn Ratchakitprakarn, Naphat Chantaravisoot, Kriangsak Faikhruea, Withsakorn Sangsuwan, Medena Noikham, Worawan Bhanthumnavin, Tirayut Vilaivan, Sunchai Payungporn, Yodying Yingchutrakul, Watthanachai Jumpathong, Chanat AonbangkhenProteins are […]Pornchai Kaewsapsak
- Biocatalytic Synthesis of Phenyl Benzoate Esters Using the Amide Ligase ClxA October 7, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00205B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alex Ascham, Qingyun Tang, Ian J. S. Fairlamb, Gideon GroganThe synthesis of ester bonds using lipases is one of the most frequently performed reactions in biocatalysis, yet examples of the enzymatic synthesis of […]Alex Ascham
- Comparative Aptamer Profiling Reveals Cell Surface Remodeling and Emergence of Noncanonical Cell Surface Protein Under Oncogenic Signaling October 2, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00110B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jungo Kakuta, Kenji Ohba, Hideaki Ogasawara, Kyohei Okahara, Kazumi Emoto, Hiroaki Sako, Miho Sekai, Yasuyuki Fujita, Toshio Imai, Yogo SakakibaraIdentifying cell type-specific molecular markers on the cancer cell surface is essential for understanding […]Jungo Kakuta
- Glyco-functionalization of ECM mimics, influence in morphology and cell behaviour Authors October 2, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00185D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maddalena Bracchi, Francesco Nicotra, Laura RussoCurrent tissue engineering strategies primarily focus on replicating mechanical properties of the extracellular matrix (ECM); however, several studies have underscored the critical role of the ECM biochemical cues […]Maddalena Bracchi
- Thiazole peptidomimetics as chemical modulators of KRAS gene expression via G-quadruplex stabilization October 1, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00046G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Debasmita Biswas, Ananta Ananta Gorai, Sandip Maiti, Ritapa Chaudhuri, Sayantan Pradhan, Jyotirmayee DashKRAS is one of the most frequently mutated oncogenes in human cancers and remains a challenging target for therapeutic intervention, often […]Debasmita Biswas
- Identification of ligands for E3 ligases with restricted expression using fragment-based methods October 1, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00198F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alex G. Waterson, Brian D. Lehmann, Zhenwei Lu, John L. Sensintaffar, Edward T. Olejniczak, Bin Zhao, Tyson Rietz, William G. Payne, Jason Phan, Stephen W. FesikNMR-based screening identified fragment hits that bind to […]Alex G. Waterson
- Selective Labeling and Visualization of Viral and Bacterial Neuraminidases using Ortho-Quinone Methide-Based Probes September 30, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00170F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Erianna Alvarado Melendez, K. Strijbis, Tom WennekesNeuraminidases (NAs) are critical virulence factors in pathogens. In viruses such as influenza A, neuraminidase facilitates the release of virions, thereby enabling infection propagation. In pathogenic bacteria, […]Erianna Alvarado Melendez
- New Insights into the Structure and Dynamics of the Epigenetic Modifications on DNA October 12, 2025
