RSC – RSC Chem. Biol. latest articles- Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase. December 9, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00278H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mia Ellen Foran, Y. T. Candace Ho, Józef Romuald Lewandowski, Matthew JennerIterative polyketide synthases (iPKSs) rely on communication between acyl carrier protein (ACP) and acyltransferase (AT) domains to ensure efficient delivery of starter […]Mia Ellen Foran
- Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue DEAtC December 7, 2025RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00243E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ana Shalamberidze, Harrison R. Pearce, Andrew L. Cooksy, Byron W. PurseIn solution and single-stranded DNA, DEAtC predominantly adopts a weakly emissive thymine-like tautomer, whereas base pairing with guanine or inosine stabilizes its bright […]Ana Shalamberidze
- A nonavalent BODIPY with a multivalent arrangement of α-mannosides enables lectins recognition in fluorescence-based assays December 5, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00190K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Edvin Purić, Giacomo Biagiotti, Jacopo Tricomi, Janez Mravljak, Stefano Cicchi, Marco Laurati, Yvette van Kooyk, Fabrizio Chiodo, Iztok Urbancic, Marko Anderluh, Barbara RichichiWe report here on the use of the Tris-BODIPY-OH as a […]Edvin Purić
- Protein Mannosylation in Actinobacteria an Enigmatic Post-translational Modification December 5, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00270B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cameron B King, Warren WakachukProtein glycosylation is a very common post-translational modification seen in all branches of biology. The functional roles for protein glycosylation are many and varied, essential in eukaryotes but […]Cameron B King
- Heterologous biosynthetic crosstalk with the native mansouramycin cluster in Streptomyces albus Del14 reveals unexpected metabolites December 3, 2025RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00235D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marc Stierhof, Liliya Horbal, Patrick Oberhäuser, Anja Palusczak, Peyton Cox, Maria Lopatniuk, Christopher Ruf, Josef Zapp, Andriy LuzhetskyyBiosynthetic interactions between Streptomyces albus Del14 and heterologous gene clusters lead to the production of new metabolites.To cite […]Marc Stierhof
- DNA-programmed bispecific peptide assemblies for delivering cytotoxic payload to cells expressing EGFR and MET receptors December 3, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00238A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pritam Ghosh, Huyen Dinh, Oliver SeitzInteractions of bispecific DNA–peptide complexes with EGFR and MET on A549 cells showed a marked distance-affinity profile. The conditional cytotoxicity of constructs armed with auristatins is contingent on […]Pritam Ghosh
- Differential Regulation of SIRT5 Activity by Reduced Nicotinic Acid Riboside (NARH) December 2, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00191A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abu Hamza, Dickson Donu, Emily Boyle, Rasajna Madhusudhana, Alyson M Curry, Yana CenSIRT5, one of the human sirtuins, catalyzes the removal of acyl substitutions from lysine residues in a NAD+-dependent manner. In addition […]Abu Hamza
- Subunit-specific isotope labelling of heteromeric complexes using cell-free protein expression: application to the 760 kDa ClpXP molecular machine December 2, 2025RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00259A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Astrid Audibert, Annelise Vermot, Mathieu Trauchessec, Karine Giandoreggio, Daphna Fenel, Aline Le Roy, Chloee Tymen, Basile Moscatello, Lauren Gandy, Caroline Mas, Lionel Imbert, Jerome BoisbouvierAn optimised, economical cell-free protocol for producing perdeuterated, methyl-labelled […]Astrid Audibert
- Late-stage peptide modification with salicylaldehyde tag enhances affinity for nuclear factor-kappa B essential modulator December 1, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00282F, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mattia Mason, Kaliroi Peqini, Federico Uggeri, Diego Rondelli, Sara Sattin, Luca Pignataro, Sara Pellegrino, Laura Belvisi, Edoardo Scarpa, Raffaella Bucci, Alberto Dal CorsoWe introduce a versatile click-chemistry strategy for a tailored insertion of […]Mattia Mason
- Identification of mono-ADP-ribose readers using well-defined photoaffinity-based probes November 28, 2025RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00176E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Femke L. A. M. van der Heijden, Suzanne A. Weijers, Spyridoula Kondyli, Onno Bleijerveld, Michiel Vermeulen, Dmitri V. FilippovThis study introduces new photoaffinity-based probes to identify mono-ADP-ribose readers. Using human cell extracts, it […]Femke L. A. M. van der Heijden
- Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase. December 9, 2025
