RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin Tháng 7 18, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00124B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nils Imse, Lucia Rojas, Cristina Gil Herrero, Sebastian Thallmair, JeongSeop Rhee, Nadja SimethLight-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable […]
  Nils Imse
• Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition Tháng 7 17, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00106D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander Dahlqvist, Rob Marc Go, Chandan Kishor, Hakon Leffler, Helen Blanchard, Ulf J. NilssonGalectins are a family of carbohydrate-recognising proteins involved in regulation of cell adhesion and cell signaling, leading to roles in […]
  Alexander Dahlqvist
• Regioselective Rapid Ene-type Reaction (RRER) Enables Bioconjugation of Histone Serotonylation Tháng 7 16, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00159E, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinghua Wu, Huapeng Li, Adam Lovato, Andrew Michael Symasek, Zeng Lin, Qingfei ZhengTriazolinedione (TAD) derivatives have been commonly utilized as protection and labeling reagents for indole and phenol moieties via a reversible ene-type […]
  Jinghua Wu
• Discovery of an Exquisitely Selective WDR5 Chemical Probe Accelerated by a High-Quality DEL-ML Hit Tháng 7 16, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00109A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lasse Hoffmann, Christopher Lenz, Frederic Farges, Serah W. Kimani, Johannes Dopfer, Sabrina Keller, Martin P. Schwalm, Hanna Holzmann, Andreas Krämer, Aiping Dong, Fengling Lu, Irene Chau, Levon Halebelian, Matthias Gstaiger, Susanne Müller, Stefan […]
  Lasse Hoffmann
• Chemoenzymatic synthesis of sialylated and fucosylated mucin analogs reveals glycan-dependent effects on protein conformation and degradation Tháng 7 13, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00111K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amanda M. Wood, Casia L. Wardzala, Jessica R. KramerSynthetic mucins with tunable glycosylation were prepared by a combination of NCA polymerization and enzymatic sialylation and fucosylation and were used to probe glycan-dependent effects […]
  Amanda M. Wood
• Unravelling Structure-function Interactions Between Fluorinated Heparan Sulfate Mimetics and Signaling Proteins Tháng 7 9, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00174A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Virendrasinh Mahida, Rakesh Raigawali, Paula González, Ana Gimeno, Shani Leviatan Ben-Arye, Saurabh Anand, Sandhya Mardhekar, Jesus Jimenez-Barbero, vered Padler-karavani, Raghavendra V KikkeriFluorinated carbohydrates are emerging scaffolds in glycobiology, enabling the elucidation of the […]
  Virendrasinh Mahida
• Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein Tháng 7 9, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00141B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tommaso Garfagnini, Zvi Hayouka, Assaf FriedlerRandom peptide mixtures target multiple hotspots at once and inhibit the aggregation of the Axin RGS L106R protein more effectively than hotspot-specific inhibitors, providing a chaperone-inspired protection against […]
  Tommaso Garfagnini
• Outstanding Reviewers for RSC Chemical Biology in 2024 Tháng 7 7, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB90026C, Editorial Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.We would like to take this opportunity to highlight the Outstanding Reviewers for RSC Chemical Biology in 2024, as selected by the editorial team for their significant contribution to the journal.To cite this […]
• Exploring the immunoproteasome's substrate preferences for improved hydrolysis and selectivity Tháng 7 6, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00114E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Christine S. Muli, Cody A. Loy, Darci J. TraderThe proteasome is an integral macromolecular machine responsible for regulated protein degradation, and its barrel-like core particle (CP) hydrolyzes protein substrates into peptide fragments.To cite […]
  Christine S. Muli
• Structure-guided engineering of a polyphosphate kinase 2 class III from an Erysipelotrichaceae bacterium to produce base-modified purine nucleotides Tháng 7 6, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00108K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel M. Mitton-Fry, René Rasche, Ann-Marie Lawrence-Dörner, Jannik Eschenbach, Aileen Tekath, Andrea Rentmeister, Daniel Kümmel, Nicolas V. CornelissenThe polyphosphate kinase 2 class III from an Erysipelotrichaceae bacterium is highly promiscuous. We determined the […]
  Rachel M. Mitton-Fry