RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• RNA-binding fluorogenic probes: G-clamp conjugated with a thiazole orange derivative for screening RNA-binding small molecules Tháng mười một 3, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00078E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ryosuke Nagasawa, Kazumitsu Onizuka, Ryohei Iwata, Kosuke Tsuzuki, Kaoru R. Komatsu, Emi Miyashita, Sayaka Dantsuji, Hirotaka Murase, Hirohide Saito, Fumi NagatsugiWe developed a novel fluorescent indicator, TO-G-clamp, by conjugating a thiazole orange derivative […]
  Ryosuke Nagasawa
• High-Resolution structure of proIAPP(1-48) fibrils suggests a mechanistic pathway for diabetes-associated IAPP fibril polymorphs Tháng 10 31, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00228A, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dylan Valli, Michał MajThe human islet amyloid polypeptide (hIAPP) aggregates into amyloid fibrils that contribute to β-cell failure in type 2 diabetes. hIAPP is produced from a 67-residue precursor, proIAPP, but incomplete cleavage...The […]
  Dylan Valli
• Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders Tháng 10 29, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00125K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kohei Tsuji, Xueyuan Huang, Maho Miyamoto, Sayaka Sukegawa, Hidetomo Yokoo, Hiroaki Takeuchi, Yosuke Demizu, Hirokazu TamamuraAn HIV-1 accessory protein Vpr-derived peptide functions as an E3 ligase ligand, and this peptide-containing molecules successfully degraded […]
  Kohei Tsuji
• Investigating the utilization mechanism and kinetics of sialic acid mimetics in mammalian cell lines Tháng 10 29, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00193E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Eline A. Visser, Daniël L. A. H. Hornikx, Moritz Rahm, Özden Öztürk, Venetia Psomiadou, Matteo Calzari, Celine Mennen, Sam J. Moons, Martin Jaeger, Dirk J. Lefeber, Christian Büll, Thomas J. BoltjeSialic acid mimetics […]
  Eline A. Visser
• Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1 Tháng 10 28, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00323C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Emily C. Hank, Nicholas D. D’Arcy-Evans, Emma Rose Scaletti, Carlos Benítez-Buelga, Olov Wallner, Florian Ortis, Kaixin Zhou, Liuzhen Meng, Alicia del Prado, Patricia Calvo, Ingrid Almlöf, Elisée Wiita, Karen Nierlin, Sara Košenina, Andreas […]
  Emily C. Hank
• Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2 Tháng 10 28, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00177C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cassandra R. Kennedy, Katherine A. McPhie, Aini Vuorinen, Jane Dudley-Fraser, Diego Esposito, Sarah Maslen, William J. McCarthy, Jonathan Pettinger, J. Mark Skehel, Jacob Bush, David House, Katrin RittingerIdentification of active site inhibitors of […]
  Cassandra R. Kennedy
• A novel class of small-molecule inhibitors targeting bacteriophage infection Tháng 10 27, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00120J, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Konstantin Plöchl, Thomas BöttcherDiscovery of benzimidazylpyrazoles as a new class of synthetic bacteriophage antivirals provides a chemical tool enabling the study of disease-related phage–host interactions.To cite this article before page numbers are assigned, […]
  Konstantin Plöchl
• A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition Tháng 10 23, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00233H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Paige A. Barta, Leopold Garnar-Wortzel, Timothy R. Bishop, Rachel E. Hayward, Lauren M. Hargis, James B. Shaum, Hui Si Kwok, Brian B. Liau, Benjamin F. Cravatt, Michael A. ErbTranscriptional regulatory proteins are frequent […]
  Paige A. Barta
• Screening and machine learning-based prediction of translation-enhancing peptides that reduce ribosomal stalling in Escherichia coli Tháng 10 21, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00199D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Teruyo Ojima-Kato, Gentaro Yokoyama, Hideo Nakano, Michiaki Hamada, Chie MotonoTranslation-enhancing peptides (TEPs) that reduce ribosomal stallling in Escherichia coli were identified through comprehensive screening, and their activity was predicted using a machine learning […]
  Teruyo Ojima-Kato
• Native mass spectrometry of membrane proteins reconstituted in peptidiscs Tháng 10 21, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00236B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Agrima Deedwania, Yi Wang, Carol V. Robinson, Jani R. BollaMembrane proteins and lipids are essential for a wide range of cellular processes, making their structural characterisation essential for understanding biological function.To cite this […]
  Agrima Deedwania