RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• A Non-Canonical Function of RNF8 Opposes TRAF6-Mediated Stabilization of HIF1α Tháng 6 7, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D5CB00209E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Larissa Ringelstetter, Elisabeth Mersdorf-Weber, Kenji Schorpp, Kamyar HadianUbiquitination is a central regulatory mechanism controlling protein stability and signaling in eukaryotic cells. The precise control of this machinery is crucial to avoid the development […]
  Larissa Ringelstetter
• Introducing Azobenzenes as Solid Phase Peptide Synthesis Linkers Tháng 6 7, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00028B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Connor B Śmieja, Lizun Xin, Tianhui Tang, Ryan Tan, Martin Lee, Alison N HulmeOrthogonally cleavable linkers are essential tools in solid-phase peptide synthesis (SPPS). We present a fluorogenic Cotext-decoration:underline"umarin-Ltext-decoration:underline"oaded Aztext-decoration:underline"obenzene (COLAZ) linker for […]
  Connor B Śmieja
• Thio-Modification Effects on mRNA Translation Using a PureCap-Based Capping Method Tháng 6 4, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00047A, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zheyu Meng, Yiwei Liu, Yuko Nakashima, Masahito Inagaki, Seigo Kimura, Yukari Kondo, Fumitaka Hashiya, Naoko Abe, Noriko Saito Tarashima, Noriaki Minakawa, Yasuaki Kimura, Hiroshi AbeControlling translational efficiency, stability, and innate immune recognition remains […]
  Zheyu Meng
• The γ-Secretase Complex: From Discovery to Therapeutic Target Tháng 6 4, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00022C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shweta R. Malvankar, Michael Scott Wolfeγ-Secretase is an intricate intramembrane aspartyl protease that cleaves within the transmembrane domain of ~150 substrates and considered the 'proteasome of membrane'. This enzyme consists of four […]
  Shweta R. Malvankar
• Methylation of DNA duplexes regulates cGAS-mediated innate immune activation via condensate formation Tháng 6 3, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00059B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kunihiko Morihiro, Manami Baba, Moeko Yamada, Akimitsu OkamotoExogenous DNA activates innate immunity via the cGAS–STING pathway, but the impact of chemical modifications has not been investigated sufficiently. Here, we show that DNA duplexes […]
  Kunihiko Morihiro
• Precursor gene engineering expands the loop region of the lasso peptide microcin J25 Tháng 6 1, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00126B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hui-Ni Tan, Julian D. Hegemann, Manuel Maestre-Reyna, John ChuThe lasso peptide microcin J25 has a unique mechanically interlocked structure. We show that multiple amino acids of diverse types can be inserted into its […]
  Hui-Ni Tan
• Real-time monitoring of glycocarrier formation unravels cryptic details in glycosyl transfer Tháng 5 31, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00069J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryan D. Packer, Angelo Gallo, Alexander D. Cameron, Somnath Mondal, Józef R. Lewandowski, Manuela TosinA real-time fluorescence-based assay has been developed to unveil molecular details of glycocarrier formation in health and disease.To cite […]
  Ryan D. Packer
• Exploring the GM-CSF histidine triad as a modulator of structure, molecular motion, and ligand binding Tháng 5 31, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00019C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jennifer Y. Cui, Iz Varghese, Anna S. Bock, Mariana Floody, Fuming Zhang, Brenda M. Rubenstein, George P. LisiCan mutations in the GM-CSF histidine triad mimic the structural, dynamic and binding properties of its […]
  Jennifer Y. Cui
• Synthesis and characterization of a novel phosphatidylinositol 5-phosphate (PI(5)P) photoaffinity probe Tháng 5 31, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00148C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Glen Brodie, Ahmed Sayed, Sarah Kreuz, Wolfgang Fischle, Stuart J. ConwayA novel PI(5)P photoaffinity probe was synthesized. The probe was characterized in copper-catalyzed alkyne-azide click reactions with the known PI(5)P nuclear binding proteins […]
  Glen Brodie
• Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4 Tháng 5 28, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00315F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Andrej Kovacevic, Aleksandar Salim, Crisálida Borges, Patrick Meraldi, Sascha HoogendoornBifunctional degraders based on the PLK4 inhibitor centrinone exhibit diverging cellular profiles of stabilization through inhibition and degradation through a PROTAC-mechanism – depending on […]
  Andrej Kovacevic