RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• The γ-Secretase Complex: From Discovery to Therapeutic Target June 4, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00022C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shweta R. Malvankar, Michael Scott Wolfeγ-Secretase is an intricate intramembrane aspartyl protease that cleaves within the transmembrane domain of ~150 substrates and considered the 'proteasome of membrane'. This enzyme consists of four […]
  Shweta R. Malvankar
• Thio-Modification Effects on mRNA Translation Using a PureCap-Based Capping Method June 4, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00047A, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zheyu Meng, Yiwei Liu, Yuko Nakashima, Masahito Inagaki, Seigo Kimura, Yukari Kondo, Fumitaka Hashiya, Naoko Abe, Noriko Saito Tarashima, Noriaki Minakawa, Yasuaki Kimura, Hiroshi AbeControlling translational efficiency, stability, and innate immune recognition remains […]
  Zheyu Meng
• Methylation of DNA duplexes regulates cGAS-mediated innate immune activation via condensate formation June 3, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00059B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kunihiko Morihiro, Manami Baba, Moeko Yamada, Akimitsu OkamotoExogenous DNA activates innate immunity via the cGAS–STING pathway, but the impact of chemical modifications has not been investigated sufficiently. Here, we show that DNA duplexes […]
  Kunihiko Morihiro
• Precursor Gene Engineering Expands the Loop Region of the Lasso Peptide Microcin J25 June 1, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00126B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.HUI NI TAN, Julian Hegemann, Manuel Maestre-Reyna, John ChuMicrocin J25 ( MccJ25) is the prototypical member of the lasso peptide family, characterized by a mechanically interlocked structure. Scientists have long been interested in […]
  HUI NI TAN
• Synthesis and characterization of a novel phosphatidylinositol 5-phosphate (PI(5)P) photoaffinity probe May 31, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00148C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Glen Brodie, Ahmed Sayed, Sarah Kreuz, Wolfgang Fischle, Stuart J. ConwayA novel PI(5)P photoaffinity probe was synthesized. The probe was characterized in copper-catalyzed alkyne-azide click reactions with the known PI(5)P nuclear binding proteins […]
  Glen Brodie
• Real-time monitoring of glycocarrier formation unravels cryptic details in glycosyl transfer May 31, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00069J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryan D. Packer, Angelo Gallo, Alexander D. Cameron, Somnath Mondal, Józef R. Lewandowski, Manuela TosinA real-time fluorescence-based assay has been developed to unveil molecular details of glycocarrier formation in health and disease.To cite […]
  Ryan D. Packer
• Exploring the GM-CSF histidine triad as a modulator of structure, molecular motion, and ligand binding May 31, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00019C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jennifer Y. Cui, Iz Varghese, Anna S. Bock, Mariana Floody, Fuming Zhang, Brenda M. Rubenstein, George P. LisiCan mutations in the GM-CSF histidine triad mimic the structural, dynamic and binding properties of its […]
  Jennifer Y. Cui
• Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4 May 28, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00315F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Andrej Kovacevic, Aleksandar Salim, Crisálida Borges, Patrick Meraldi, Sascha HoogendoornBifunctional degraders based on the PLK4 inhibitor centrinone exhibit diverging cellular profiles of stabilization through inhibition and degradation through a PROTAC-mechanism – depending on […]
  Andrej Kovacevic
• Pharmacology of estrogen-related receptors (ERRs) agonists May 28, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00077K, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mohamed O. Radwan, Soumitra Guin, Thomas P. BurrisRecent advances in the development of synthetic agonists for the orphan receptors, estrogen-related receptors (ERRs), has revealed their exercise mimetic activity and beneficial effects in […]
  Mohamed O. Radwan
• The inhibitors of 17beta-HSD10: are they any good? May 27, 2026
  RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00093B, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ernst Kwa, Charlene E Ogilvie, Natalie C Kormos, Alison J.E. Green, Terry Smith, Frank J Gunn-MooreThe advent of the first disease-modifying therapies for Alzheimer’s disease (AD) has renewed optimism for effective prevention […]
  Ernst Kwa