RSC – RSC Chem. Biol. latest articles- The Position of Hydrophobic Residues Impacts Cellular Uptake and Intracellular Localization of Cell Penetrating Peptides May 13, 2026RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00107F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Adeline Schmitt, Helma WennemersCell-penetrating peptides (CPPs) are widely used to deliver cargo into mammalian cells, yet efficient cellular uptake and endosomal escape remain key challenges. In this study, we evaluated how hydrophobic (4S)-4-cyclohexylproline...The […]Adeline Schmitt
- Scarless One-Tube Genome Assembly via Computationally Optimized Uracil-DNA Glycosylase Reactions May 12, 2026RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D5CB00317B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rachel Marie Carson, Patrick Martin Needham, Pedro Fernandez Mendoza, Sam R. NugenSynthetic biology enables the creation of systems such as bacteriophage (phage)-based biosensors, leveraging the innate specificity and efficiency of phages to rapidly […]Rachel Marie Carson
- Ortho-Substituents Govern Aryl Aldehyde Reactivity: Toward Lysine-Targeted, Tunable Inhibitors of Glucose-6-Phosphate Dehydrogenase May 11, 2026RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00070C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bronwyn E Rowland, Kelsey D. Roy, Adil Alkaş, Mirele Barsoum, Tangweth Kuot, Jesse C Fuller, Adrien J. Naudet, Elisa Ospanow, David L JakemanCertain drugs achieve highly potent and long-lasting enzyme inhibition by forming […]Bronwyn E Rowland
- The working lives of neuronal 5-HT2A receptors from the outside in May 6, 2026RSC Chem. Biol., 2026, Accepted ManuscriptDOI: 10.1039/D6CB00014B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aneesah Jabar, Mikayla Pinto, Terry Hebert5-HT2A receptors have been shown to play critical roles in regulating neuronal signalling networks and brain plasticity. They have become important targets for the treatment of resistant […]Aneesah Jabar
- Native MS and ligand observed NMR uncovers subtle SLiM binding variations that mediate HSP90-Hop PPI modulation May 5, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00112B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tara K. Davids, Daniel A. Kusza, Shannon K. Misplon, Josef C. Späth, Richwell Mhlanga, David J. Clarke, Beatriz G. de la Torre, Fernando Albericio, Adrienne L. Edkins, Marwaan Rylands, Clinton G. L. VealeOrthogonal […]Tara K. Davids
- Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design May 5, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00062B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zhuoheng Pan, Yufei Pan, Huarui Zhang, Zefeng Chen, Yihao Zhang, Baoting Zhang, Aiping Lu, Ge Zhang, Sifan YuNucleic acid aptamers are synthetic, single-stranded oligonucleotides that bind targets with high affinity and specificity, […]Zhuoheng Pan
- Correction: Dynamic conformational equilibria in the active states of KRAS and NRAS May 4, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB90018F, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Enrico Rennella, Chrystèle Henry, Callum J. Dickson, Florian Georgescauld, Thomas E. Wales, Dirk Erdmann, Simona Cotesta, Michel Maira, Richard Sedrani, Saskia M. Brachmann, Nils Ostermann, John R. Engen, Lewis E. Kay, Kim S. […]Enrico Rennella
- Synthesis of Thermostable Artificial Nicotinamide Cofactors: Carba-NAD+ and Carba-NADP+ May 4, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00036C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zinnia Dsouza, Jan-Simon Jeshua Friedrichs, Manuel Döring, Nicolás Rincón Téllez, Luca Schmermund, Volker SieberCarbocyclic nicotinamide cofactors are attractive NAD(P)⁺ analogues that retain native redox activity while offering substantially enhanced chemical and thermal stability. […]Zinnia Dsouza
- A new 4-atom linker enables PROTAC development and imaging April 29, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00127K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Spyros Letsios, Giovana Carrasco, Martin Lee, Mateen Wagiet, Marta Madureira, Marley Samways, Zaid Khan, Valerie G. Brunton, Olivera Grubisha, Alison N. HulmeA rigid diyne linker gives a potent PROTAC that can be directly […]Spyros Letsios
- A fluorescence-activated droplet sorting assay for ultra-high-throughput screening of PET hydrolases based on a pH indicator April 28, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00122J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maxine Yew, Haizhen Bi, Dingjie Wang, Rui Qi, Huiling Yuan, Huanhuan Zhai, Gen Li, Qinhong Wang, Leilei ZhuUltra-high-throughput screening of PET hydrolases enabled by a pH-based fluorescence-activated droplet sorting (FADS) assay.To cite this […]Maxine Yew
- The Position of Hydrophobic Residues Impacts Cellular Uptake and Intracellular Localization of Cell Penetrating Peptides May 13, 2026
