RSC – RSC Chem. Biol. latest articles- Cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis. April 8, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00004E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rubaba R. Abanti, Dongqing Wu, Pavel KielkowskiChemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on proteome-wide scale. The strategy relies on reactivity and specificity […]Rubaba R. Abanti
- Influence of Linker Design on the Stability, Folding, and Assembly of Tethered Collagen-Mimetic Peptides April 7, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00298B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Debasis Ghosh, Anthony Robert Perez Perez, S M Mobin Sikder, Jesus Ivan Ivan Rodriguez Vasquez, Claire Zhang, Anjan Maity, Tao Ye, Andrea MergCovalently tethered collagen-mimetic peptides (CMPs) serve as synthetically programmable molecules for […]Debasis Ghosh
- Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment April 6, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00045B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sharadha Dayalan Naidu, Dina Dikovskaya, Jasmine M Walker, Charlotte J.Y. Lim Jia Yee, Annamarie J Cafferkey , Manaka Tatsuno, Jialin Feng, Terry W. Moore, Tatum Johnson, Tadashi Honda, Geoff Wells, Takafumi Suzuki, Masayuki […]Sharadha Dayalan Naidu
- Intricacies in Iron-Sulfur Cluster Function and Biogenesis: Functional Versatility, Sulfur Sources, and Enzyme Specificity April 1, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00330J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sarah M Spigelmyer, Patricia C. Dos SantosIron-sulfur (Fe-S) clusters are ancient inorganic cofactors ubiquitous across all domains of life. These cofactors associate with proteins through constitutive or transient coordination, expanding their chemistries […]Sarah M Spigelmyer
- Heck-type C-glycosylations in the synthesis of artificial nucleotides and functional nucleic acids March 26, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00078A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Robert Dörrenhaus, Andre Zenz, Stephanie Kath-SchorrHeck-reaction-mediated C-glycosylation enables efficient access to diverse artificial DNA nucleosides, supporting advanced studies of structure, function, and fluorescent nucleobase probes.To cite this article before page numbers are […]Robert Dörrenhaus
- Introduction to “Endocytosis and cellular delivery” March 26, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB90009G, Editorial Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander Kros, Georgina Such, Vincent M. RotelloAlexander Kros, Georgina Such, and Vincent Rotello introduce the RSC Pharmaceutics and RSC Chemical Biology themed collection on Endocytosis and cellular delivery.To cite this article before page […]Alexander Kros
- Synthesis and properties of L-lyxo-thioBsNA-pyrimidine nucleoside: a sulfur-containing analogue of boat-shaped pyranosyl nucleic acid March 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00034G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Miyu Ito, Suguru Matsumoto, Natsuki Yokota, Hidekazu Hiroaki, Tetsuya KodamaL-lyxo-thioBsNA, a boat-shaped nucleic acid (BsNA) analogue designed to enhance hydrophobicity – a property strongly influencing its physical characteristics – was synthesized.To cite this […]Miyu Ito
- Mutagenesis-based evolution enables rapid retargeting of L-aptamers for structured RNA recognition March 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00057F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xuan Han, Tyler Guilbault, Jonathan T. SczepanskiMutagenesis-based SELEX enables rapid retargeting of cross-chiral L-aptamers, generating orthogonal binders that discriminate structured RNAs differing by a single nucleotide.To cite this article before page numbers are […]Xuan Han
- Lipid droplet dynamics in metabolic regulation March 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00081A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ralf Weiskirchen, Sabine Weiskirchen, Amedeo LonardoLipid droplets are dynamic organelles for lipid storage and metabolic signaling. This review summarizes their biogenesis and turnover, tissue-specific roles in metabolic disease, and therapeutic targeting opportunities.To […]Ralf Weiskirchen
- Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity March 24, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00316D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maho Katsuyama, Taiki Matsubayashi, Yang Ying, Su Su Lei Mon, Takayuki Kuroda, Kie Yoshida-Tanaka, Rintaro Iwata Hara, Takeshi Yamada, Kumiko Ui-Tei, Kotaro YoshiokaGuanine bases drive acute neurotoxicity of gapmer antisense oligonucleotides after intracerebroventricular […]Maho Katsuyama
- Cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis. April 8, 2026
