RSC – Lab Chip latest articles- Inkube: an all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange March 2, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00971E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Benedikt Maurer, Selina Fassbind, Tobias Ruff, Jens Duru, Giusy Spacone, Theo Rodde, János Vörös, Stephan J. IhleA compact open-source platform merging cell culturing, electrophysiology, and automated perfusion, which provides robust environmental control and continuous […]Benedikt Maurer
- High-Throughput and Efficient Fabrication of Engineered Skeletal Muscle Tissue via Streamlined 3D Multimaterial Bioprinting March 2, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01040C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tae-Eun Lim, Ashfaq Ahmad, Yeong-Jin Choi, Hee Gyeong YiSkeletal muscle diseases have led to an increasing need for a range of physiologically relevant organ-on-a-chip and three-dimensional (3D) culture platforms owing to their clinical significance […]Tae-Eun Lim
- Real-Time Impedance-Based Cell Migration Measurements with Integrated Electrodes on Porous Membranes for Next Generation Microphysiological Systems March 2, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00898K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Karina Torres-Castro, Aditya Rane, Darwin R. ReyesWe present a novel microfluidic device capable of electrically interrogating both surfaces of a porous membrane quantitatively and in real time using electrical impedance spectroscopy to monitor cell […]Karina Torres-Castro
- 3D ECM-Inflammation Model on a Microfluidic Chip for Neutrophil Transmigration from Whole Blood Investigations February 27, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00554J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shide Bakhtiari, Vanessa Velasco, Ronald DavisNeutrophils have been linked to several inflammation diseases. To study the role of neutrophils in inflammation diseases and conditions, in vitro inflammation assays have been developed. Two drawbacks of […]Shide Bakhtiari
- Vascularizing organoids-on-chip for perfused and personalized models February 27, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00890E, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bianca Menzani, Priscille De Gea, Xavier Gidrol, Emily TubbsThis review discusses the current strategies and technical considerations for vascularizing organoids-on-chip, highlighting their potential to improve physiological relevance, functional performance, personalization and translational applicability.To […]Bianca Menzani
- Hydrogel microwell with pneumatic soft actuator for compression formation of three-dimensional cellular tissue February 27, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00731C, PaperRyota Kawamae, Atsushi Takata, Kenjiro Takemura, Yuta KurashinaA unique culture system was devised by integrating a pneumatic soft actuator and a hydrogel microwell for cellular tissue formation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Ryota Kawamae
- Dual Vision-equipped Microfluidic Chip for Spatiotemporal Sequential Pick-and-Place of Oocytes February 27, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01118C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shuzhang LIANG, Hao Mo, Yuguo Dai, Hirotaka Sugiura, Satoshi Amaya, Fumihito AraiOocytes have long been used as a fundamental biological model in bioengineering research such as gene expression analysis, electrophysiological measurements, and drug screening. […]Shuzhang LIANG
- Integrated Strategy for Breast Cancer Biomarker Analysis Using Dual Ionic Liquid Aqueous Biphasic Systems and Microfluidic Immunoassays February 26, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01010A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria S. M. Mendes, Inês Agostinho, Maria C. Souza, Virginia Chu, Mara G. Freire, Francisca A. e Silva, Joao Pedro CondeHuman epidermal growth factor receptor 2 (HER2) is a key biomarker in breast cancer […]Maria S. M. Mendes
- Integrated microfluidic platform based on potentiometric Sonogel-Carbon sensors for the simultaneous determination of Na⁺ and K⁺ in untreated human plasma and serum February 25, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00117C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Álvaro Jesús Sainz-Calvo, Álvaro Cordero-Hernández, Marina Jiménez-Rodríguez, Virginia García- Rodríguez, Juan Josè Garcia-Guzman, Dolores Bellido-Milla, José María Palacios-Santander, Laura Cubillana AguileraIn the present work, two potentiometric sensors for the simultaneous determination of sodium and […]Álvaro Jesús Sainz-Calvo
- On-chip acoustic chaotic micromixer for point-of-care applications February 24, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01183C, PaperXian Chen, Chuanchao Zhang, Yaping Wang, Xuexin Duan, Yunhua GaoWe proposed an acoustofluidic platform actuated by the Lamb wave resonator array, which facilitates sample pretreatment, chaotic mixing, analyte trapping and detection on a single chip for the truly “sample-in-answer-out” point-of-care detection.To cite this article before page numbers are assigned, […]Xian Chen
- Stroke Volume Analog on a Chip - In Vitro Hydrodynamic Model of Cardiac Pumping Efficiency February 23, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00547G, PaperJohn Zimmerman, Luke A. MacQueen, Douglas Henze, Daniel J. Drennan, Sean L. Kim, Herdeline Ann Ardoña, Suji Choi, Qianru Jin, Kevin Kit ParkerStroke volume serves as a key metric of heart performance. Despite its central importance in diagnosing many cardiomyopathies, there exists limited in vitro models whose readouts can […]John Zimmerman
- Correction: Reversible and reusable compartmentalized thermoplastic chip for coculture of dorsal root ganglion neurons February 20, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC90129D, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Solène Moreau, Raul Flores-Berdines, Anne Simon, Tatiana El Jalkh, Guillaume Taret, Anna Fomina, Céline Dargenet-Becker, André Estevez-Torres, Sophie Bernard, Hugo SalmonTo cite this article before page numbers are assigned, use the DOI form of […]Solène Moreau
- Vector-free DNA transfection by nuclear envelope mechanoporation February 20, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00871A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Leyla Akh, Apresio K. Fajrial, Sunwoo Sohn, Benjamin Seelbinder, Xin Xu, Wei Tan, Jill E. Slansky, Corey P. Neu, Xiaoyun DingA nanolancet-based microfluidic mechanoporation device can produces reliable pores on the cell membrane and […]Leyla Akh
- A portable, low-cost, point-of-care DNA amplification kit with impedance-based detection for decentralized antimicrobial resistance diagnostics February 20, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00062B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Koosha Karimi, Miriam Arroyo, Erin E. Chille, Timothy G. Stephens, Donal Barrett, Vicent Pelechano, Debashish Bhattacharya, Mehdi JavanmardThis study presents a low-cost, portable DNA amplification kit that performs modified LAMP to produce DNA nanoballs, […]Koosha Karimi
- Intelligent image-activated sorting of large cells enabled by elasto-inertial focusing February 19, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01143D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuzuki Nagasaka, Akihiro Isozaki, Hiroki Matsumura, Natsumi Tiffany Ishii, Norah Roels, Mina Rassuli, Kelvin C. M. Lee, Walker Peterson, Tianben Ding, Keisuke GodaWe integrated a long, straight, elasto-inertial focuser into an intelligent image-activated cell […]Yuzuki Nagasaka
- Engineering organs-on-a-chip via multi-channel microfluidics February 19, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00598A, Critical ReviewJi Qiu, Jia Yang, Lihao Liu, Jiameng Wen, Jiachen Yang, Wenwan Shi, Xiaoxiang Gao, Jing Sun, Ling Bai, Xiaojiang Liu, Zhongze GuThis review summarizes the design strategies, fabrication methods and applications of multi-channel microfluidic organ-on-a-chip systems, and outlines the key challenges and future opportunities for advancing disease modeling […]Ji Qiu
- Bone-on-leaf-chip for the study of lung cancer bone metastasis February 18, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00951K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Qi Liu, Di Suo, Renxian Wang, Shuai Zhao, Mao Mao, Wei-Ning Lee, Yuhe Yang, Xin ZhaoA leaf vein chip was developed for simulating the actual process of lung cancer bone metastasis through a multi-scale […]Qi Liu
- WAFFLE – an automated platform for enhancing the performance of electrochemical biosensors February 18, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00988J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexandra Dobrea, Rowan Blake, Daniel Macdonald, Cormack McKenzie, Yoann Altmann, Damion K. Corrigan, Melanie JimenezWe introduce the WAFFLE – a fully automated, open-source platform combining sensor fabrication and MCMC-based analysis for enhanced electrochemical biosensing.To […]Alexandra Dobrea
- Autonomous microfluidic labs: progress and prospects February 17, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00908A, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Suyash Damir, Fernando Delgado-Licona, Andrew deMello, Milad AbolhasaniClimate change, energy demands, and health equity require rapid innovation. Autonomous microfluidic labs integrate continuous experimentation with machine learning to navigate complex experimental landscapes, dramatically accelerating discovery.To […]Suyash Damir
- Progress toward real-world diagnostic applications of microfluidic paper-based analytical devices (μPADs) February 13, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01085C, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yohei Tanifuji, Daniel CitterioProgress in μPAD development from 2017 to 2025 has been comprehensively analyzed primarily focusing on diagnostic applications, including critical comments and future perspectives.To cite this article before page numbers are […]Yohei Tanifuji
- Inkube: an all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange March 2, 2026
