RSC – Lab Chip latest articles- Building multiple microenvironmental niches using a customizable 3D printed well insert September 30, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00753D, PaperLaura A Milton, Surasak Kasetsirikul, Jorge Amaya Catano, Sofia Hilmi, Zeheng Zhou, Thomas G. Molley, Kristopher Kilian, Louis Ong, James Chirnside, Nicholas Byrom, Georgia Balshaw, Sammy Liang, Laura Jane Bray, Dietmar Hutmacher, Christoph Meinert, Yi-Chin TohThe increasing demand for advanced in vitro models that replicate physiological crosstalk between cell […]Laura A Milton
- Integrated and Turnkey Custom-Built Multiplexed Portable Platform for On-Site Electrochemical Detection September 30, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00732A, PaperParvathy Nair, Aditya Balasubramanian, Sharan K, Souvik Roy, Ponnalagu R N, Sanket GoelA compact and cost-effective device is essential to bring multiplexed biosensing from lab to the point-of-care. Electrochemical sensing has emerged as a powerful choice for developing such lab-on-chip (LOC) platforms,...The content of this RSS Feed (c) The […]Parvathy Nair
- Pressurized photobonding for 3D-printed inertial and droplet microfluidics September 30, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00433K, PaperVivek Rajasenan, Edwin Sanchez Ochoa, Aiden Begole, Amrith Karunaratne, Lisa F. Horowitz, Albert Folch, Dino Di CarloPress-cure rapidly bonds SLA-printed microfluidics with sub-100 μm fidelity, multi-height 3D routing, and >300 psi operation, enabling dense droplet arrays, inertial focusing with spacing control, viscous micromixing.To cite this article before page numbers […]Vivek Rajasenan
- Multiplexed detection of respiratory viral pathogens by isothermal amplification on an autonomously loaded chip at the point-of-care September 30, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00509D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Beatrise Berzina, Krishna Gupta, Rayan Suliman, Peter Mirtschink, Alexander Dalpke, Carsten Werner, Elisha Krieg, Lars David RennerRecent viral outbreaks have shown the need for reliable diagnostic platforms to rapidly detect various viral and bacterial […]Beatrise Berzina
- Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle September 30, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00614G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Martín Ruiz-Gutiérrez, Ainoa Tejedera-Villafranca, Sergi Pujol-Pinto, Javier Ramón-Azcón, Juan M. Fernández-CostaMyo-MOVES is a versatile platform for electrical pulse stimulation (EPS) that mimics motor neuron activation in muscle tissue and enables a wide range of […]Martín Ruiz-Gutiérrez
- Pushbutton-activated microfluidic cell-free biosensor for multiplexed pathogen detection September 29, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00337G, PaperDong Hyun Han, Yurim Kim, Yu-Jin Park, Dong-Yeon Song, Jongho Park, Jeonghwan Oh, Dong-Myung Kim, Je-Kyun ParkIn this paper, we have developed a novel cell-free biosensor based on a multiplexed pushbutton-activated microfluidic device (mPAMD) that enables simultaneous detection of multiple 16S rRNAs of pathogens in a...The content of this […]Dong Hyun Han
- Programmable Cell Culture Chips for Topographical Manipulation of Living Cells September 29, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00803D, PaperXin-Yi Wu, Jian-Miao Zhang, Meng-Yao Niu, Fan-Chun Bin, Qi Duan, Jie Liu, Xian-Zi Dong, Mei-Ling ZhengThe micro-morphological characteristics of biomaterial surfaces play a critical role in influencing cell proliferation, adhesion, and differentiation. However, the underlying mechanisms by which surface features modulate cellular behavior remain inadequately...The content of this RSS […]Xin-Yi Wu
- Stimulus-Induced Mechanical Compaction of Biological Polymer Networks via Smart Hydrogel Microstructures September 29, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00477B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vicente Salas-Quiroz, Katharina Esch, Katja ZieskeThe remodeling of the extracellular matrix by mechanical forces plays a crucial role in organizing cellular microenvironments. To study these mechanical perturbations, various methods have been developed to modify […]Vicente Salas-Quiroz
- Electrical Impedance Tomography (EIT)-Based Intracellular Conductivity Imaging for Non-invasive Cell Detection September 28, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00466G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Songshi Li, Daisuke Kawashima, Zeyang Dai, Nobuyuki Aoki, Masahiro TakeiElectrical impedance tomography (EIT)-based intracellular conductivity imaging is newly proposed as a non-invasive technique for mapping the electrical properties of living cells at the single-cell […]Songshi Li
- A streamlined lateral flow immunoassay for S. typhimurium using intrinsically multifunctional magnetic nanoprobes for capture, enrichment, and signal amplification September 28, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00437C, PaperXuechi Yin, Jingxin Hou, Jiayi Zhang, Yumiao Jian, Nosirjon Sattorov, Xinnan Liu, Jianlong Wang, Qingyu Yang, Daohong Zhang, Ibrahim A. DarwishThis work developed a lateral flow immunoassay using carboxyl-functionalized Fe3O4 nanoparticles for the sensitive detection of S. typhimurium, leveraging their dual function in magnetic enrichment and peroxidase-like catalytic signal […]Xuechi Yin
- From startup to shutdown: the dramatic rise and fall of the first at-home combo test for flu and COVID-19 September 24, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00305A, Perspective Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Morgan N. Greenleaf, Gregory L. Damhorst, Eric M. Vogel, Greg S. Martin, Wilbur A. LamLucira health|innovation, rise, and fall.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Morgan N. Greenleaf
- Signal Amplification Using Ab-AuNPs Integrated with LDI-MS Analysis for Diabetes Screening in Urine and Saliva September 24, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00700C, PaperLi-Sin Tu, Tai-Wei Liu, He-Hsuan HsiaoThe global prevalence of diabetes is rising at an alarming rate, making it the third leading cause of death worldwide. This study presented a user-friendly, straightforward, and non-invasive method for...The content of this RSS Feed (c) The Royal Society of ChemistryLi-Sin Tu
- sNails: sweat-sensing nails for unobtrusive, wearable microfluidic sweat monitoring from the dorsal distal phalanges September 23, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00586H, PaperNoelle Davis, Pooja Mehta, Amanda Kang, Liam Gillan, Jussi Hiltunen, Ali JaveyA wearable microfluidic device captures sweat on the dorsal distal phalanges of the fingers during everyday activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Noelle Davis
- Label-Free Imaging Flow Cytometry with Rare Cell Classification using Motion-Sensitive-Triggered Interferometry September 22, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00634A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eden Dotan, Dana Yagoda-Aharoni, Eli Shapira, Natan T. ShakedWe present a label-free imaging flow cytometry system that integrates a microfluidic chip imaged by a motion-sensitive (event-based) camera and an interferometric-phase-microscopy module using a simple […]Eden Dotan
- Deterministic cell pairing with simultaneous microfluidic merging and sorting of droplets September 22, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00627A, PaperKevin M. Joslin, Sophia Dateshidze, Seung Won Shin, Adam R. Abate, Iain C. ClarkPICS is a high-throughput microfluidics platform that deterministically pairs reagents or cells by simultaneously merging and sorting droplets, enabling the generation of pure populations of cell pairs in droplets or hydrogel microspheres.To cite this article before […]Kevin M. Joslin
- ECM-integrated hanging drop platform for spatially controlled assessment of immune cell regulated tumour invasion September 21, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00359H, PaperChanyang Lee, Seokgyu Han, Seulgi Lee, Jaehyun Lee, Sein Kim, Seunggyu Ko, Howon Lee, Sungsu ParkECM-integrated hanging drop platform for enabling quantitative assessment of tumour cell invasion, immune cell trafficking, and matrix mediated immunosuppressive interactions.To cite this article before page numbers are assigned, use the DOI form of citation […]Chanyang Lee
- Analysis of Sperm Beating Characteristics Using Microfluidic Trapping and Machine-Learning-Based Flagellum Tracking September 19, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00389J, PaperAisha Hamidu, Omar Abdelgawad, Ahmed Azmeer, Mohamed AbdelgawadMale infertility affects a significant portion of couples worldwide, with standard semen analysis often failing to identify functional deficiencies in sperm performance. This study presents a microfluidic platform for characterizing...The content of this RSS Feed (c) The Royal Society of ChemistryAisha Hamidu
- Correction: A nanobody-based microfluidic chip for fast and automated purification of protein complexes September 18, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC90098K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Phebe De Keyser, Mitch de Waard, Ignaas S. M. Jimidar, Sandrien Verloy, Steven Janvier, Valentina Kalichuk, Thomas Zögg, Alexandre Wohlkönig, Els Pardon, Jan Steyaert, Gert DesmetTo cite this article before page numbers are assigned, […]Phebe De Keyser
- A novel holder and microfluidic system for spatially controlled hypoxia induction, mechanical stimulation and cardiac regeneration research September 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00460H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kołodziejek Dominik, Szlachetka Aleksandra, Iwoń-Szczawińska Zuzanna, Drozd Marcin, Wojasiński Michał, Jastrzębska ElżbietaA microfluidic system with magnetic nanofiber mats and a hypoxia holder was developed for iPSC-CM and iPSC co-culture. After hypoxia simulation and mechanical […]Kołodziejek Dominik
- Barcode-integrated cellulose based microfluidic system for intelligent point-of-care blood typing September 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00688K, PaperChunrui Chen, Tonghuan Zhan, Lin Hu, Mengyuan Ding, Xianchang Wu, Heng Wang, Bing XuA new concept of cellulose-based microfluidics and barcode technology analytical devices (BloodStrips) has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Chunrui Chen
- Building multiple microenvironmental niches using a customizable 3D printed well insert September 30, 2025
