RSC – Lab Chip latest articles- Enabling the recirculation of leukocytes in a high-throughput microphysiological system (MPS) to study immune cell-vascular tissue interactions January 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01001B, PaperTyler Gerhardson, Nerses J. Haroutunian, Ryan Dubay, Joseph N. Urban, Anthony Quinnert, Brett C. Isenberg, Samuel H. Kann, Halee Kim, Robert Gaibler, Hesham Azizgolshani, Elizabeth L. Wiellette, Corin WilliamsA high-throughput microphysiological system (MPS) to study immune cell-vascular tissue interactions is achieved through advanced recirculation controls.To cite this article before […]Tyler Gerhardson
- Formation of an endometrial epithelial monolayer in a microfluidic device with human tissue-derived endometrial organoids January 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00278H, PaperSeung-cheol Shin, Yale Hahm, Yeju Jeong, Yup Kim, Junsik Park, Ji Hun Yang, Jin-A Kim, Jihee Won, Seok Chung, Jung-Yun LeePatient-derived endometrial organoids are induced to spread into a polarized epithelial monolayer inside a microfluidic chip, enabling apical-basal organization and assay-ready interfaces.To cite this article before page numbers are […]Seung-cheol Shin
- High-throughput biomimetic cycling of red blood cells: Elucidating the morpho-mechanical determinants of fatigue and clearance January 5, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01022E, PaperYahui Du, Wenjiao Wu, Yuexiu Chen, Lihang Zhu, Shuhao Ma, Fengjiang Zhang, Xuejin LiDuring their 120-day circulatory lifespan, red blood cells (RBCs) undergo repeated mechanical deformation as they traverse microcapillaries and splenic inter-endothelial slits (IES). This cyclic mechanical loading gradually impairs RBC deformability,...The content of this RSS Feed (c) […]Yahui Du
- Fully Printed and Flexible Patch for Real-Time Wireless Monitoring of Sweating Rate with Physiological Detecting January 3, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00755K, PaperHao Wen, Kailong Dong, Feiyang Huang, Zhiqing Gao, Zijian An, Rujing Sun, Xin Li, Qing Ye, Qingjun LiuHuman sweating rate reflects body hydration status and holds intrinsic significance for monitoring physiological health. This work presents a fully printed sweat rate sensor architecture, where the internal sensing layer...The content of […]Hao Wen
- CombiCTx: Screening diffusion gradients of anti-cancer drug combinations January 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00686D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christina Stelzl, Ada Lerma-Clavero, Selina Camenisch, Benoit Simon, Olle Eriksson, Oliver Degerstedt, Hans Lennernas, Femke Heindryckx, Johan Kreuger, Paul O'CallaghanThe reduced effectiveness of chemotherapy in many patients highlights the need for novel drug combinations […]Christina Stelzl
- Integrated High-Performance Microcapsule Fire Extinguishing System for Confined Spaces with Real-Time Monitoring and Early Warning Capabilities December 30, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01053E, PaperQiaosheng Pan, Jiachao Zhang, Jijie Fu, Ning Sang, Dang Ding, Peng Zhang, Chen Li, Tianpei Zhou, Ting Si, Fangsheng Huang, Zhiqiang ZhuSmall-scale fires in confined spaces represent critical precursors to catastrophic disasters, making their early suppression essential for safeguarding lives and property. However, conventional fire extinguishing systems in confined […]Qiaosheng Pan
- Gravity-induced tunable asymmetric droplet splitting for flexible and precise reagent formulation on vertical digital microfluidics. December 29, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00868A, PaperJuyue Dong, Zerui Song, kunlun guo, Hang Xu, Zhibei Qu, Zhen Gu, Hui-Feng WangDigital microfluidic enables parallel, quantitative and flexible handling of discrete droplets via electrowetting on dielectric (EWOD) force. However, droplet splitting behavior in conventional digital microfluidics is limited by the geometry...The content of this RSS Feed (c) […]Juyue Dong
- A mechanomimetic model of skin fibrosis December 29, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00560D, PaperAlberto Pappalardo, Deniz Ornek, Laura Garriga Cerda, Charlotte Y. Lee, Kristin Myers, Jeffrey W Kysar, Hasan Erbil AbaciSkin fibrosis results from excessive extracellular matrix (ECM) deposition and tissue remodeling due to persistent inflammation and mechanotransduction dysregulation. Current in vivo animal models lack human relevance, while conventional 2D...The content of […]Alberto Pappalardo
- A comprehensive toolkit for manipulation and analysis of sprouting capillary networks based on magnetic ordering of multiple EC-coated microcarriers and their use in tissue modelling and drug testing December 24, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00664C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Katarzyna O. Rojek, Antoni Wrzos, Fabio Maiullari, Konrad Giżyński, Maria Grazia Ceraolo, Claudia Bearzi, Roberto Rizzi, Piotr Szymczak, Jan GuzowskiVascularized tissue micro-arrays for high-throughput phenotypical screening.To cite this article before page numbers are assigned, […]Katarzyna O. Rojek
- Magnetophoretic long jump of magnetic microparticles in an engineered magnetic stray field landscape for highly localized and large throughput on-chip fractionation December 23, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01000D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rico Huhnstock, Lukas Paetzold, Piotr Kuświk, Arno EhresmannOn-chip spatial separation of superparamagnetic microparticles was achieved using an engineered magnetic stray field landscape created by an artificial magnetic domain pattern. It potentially enables pre-sorting of […]Rico Huhnstock
- A Tumor Spheroid Array Chip for High-Fidelity Evaluation of Liposomal Drug Delivery Through the EPR Effect December 23, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00893J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yedam Lee, Sujin Kim, Hyeyeon Koh, Jung Yeon Han, Jihoon Ko, Yeonwoo ParkConventional two-dimensional (2D) culture systems fail to recapitulate the structural and functional complexity of the tumor microenvironment (TME), limiting their translational relevance […]Yedam Lee
- A novel microfluidic multichannel electrochemical cell for multiplexed monitoring of water pollutants December 22, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00825E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tong Liu, Ivo Tichý, Jiří Homola, Amir M. AshrafiA microfluidic multichannel (4×) electrochemical cell (MMEC) was developed. Multiplexed determination of selected water pollutants Hg2+ and Pb2+ ions, catechol, and H2O2 was carried out with […]Tong Liu
- Gut health monitoring via intestinal barrier function screening using a transepidermal microneedle-based sensor December 19, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01004G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nicolas Maïno, Sihui Xu, Petter Brodin, Onur ParlakA novel microneedle sensor designed for rapid, non-invasive monitoring of intestinal barrier health.To cite this article before page numbers are assigned, use the DOI form of citation […]Nicolas Maïno
- Direct access and recovery feature of solid precipitates embedded in a microfluidic device December 19, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00816F, PaperMasashi Kobayashi, Risa Fujita, Faisal bin Nasser Sarbaland, Masahiro Furuya, Daiki TanakaOur ‘trap-and-harvest’ device integrates in situ solid formation in trapped droplets with transfer to a physically accessible chamber, facilitating the direct harvesting of solid precipitates from the microfluidic device.To cite this article before page numbers are assigned, use […]Masashi Kobayashi
- Magnetic smartphone microflow cytometry enables rapid CD4/CD8 T cell quantification December 19, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00801H, PaperHee Sik Shin, Sung Joo Lee, Jae In Kim, Jung Ho Kim, Jun Yong Choi, Su Jin Jeong, Sungyoung ChoiWe present MACC, a smartphone-based microflow cytometry platform for rapid, fully quantitative CD4+/CD8+ T-cell counting without fluorescent labels.To cite this article before page numbers are assigned, use the DOI form […]Hee Sik Shin
- Directed dielectrophoretic assembly and separation on microelectrodes patterned via stereolithography 3D-printed shadow masks December 18, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00829H, PaperEunhwa Jo, Chanwook Cha, Yeongjun Kim, Jeongjae Seo, Eun Jung Lee, Koohee HanBy employing an SLA-fabricated shadow mask for precise electrode patterning, this work demonstrates that dielectrophoretic separation and assembly can be robustly and reliably controlled.To cite this article before page numbers are assigned, use the DOI form of […]Eunhwa Jo
- Sacrificial Oil Shell Method for the Generation of Alginate Microbeads Adapted to Multicellular Spheroid Culture December 17, 2025Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00913H, PaperLeon Rembotte, Jean Cappello, Adrien Dewandre, Marie Mettler, Jean Marcel Constantin Septavaux, Pierre Nassoy, Benoit ScheidThree-dimensional cell culture provides a powerful framework for studying the growth of tissue in vitro. To account for biological variability, it is important to generate a large number of model...The content of this RSS […]Leon Rembotte
- QuickDraw: detecting HIV in whole blood using an integrated paper-based consumable that enables direct amplification of purified RNA from paper December 17, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00897B, PaperAlexander L. Evans, Alexandra K. Sogn, Andrea C. Mora, Moses N. Arthur, Justin R. Leach, Sebastian I. Bosch, Shruthika Araselvan, Jeffrey W. Beard, Stephen Dewhurst, Charles R. Mace, Benjamin L. MillerA device for passive isolation of viral RNA from whole blood enables HIV testing at the point of care.To […]Alexander L. Evans
- Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow December 17, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00742A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aaron D. Morgan, Robert Dzhanaev, Andrea Gorgels, Jan Ritter, Johanna C. Clauser, Felix Stockmeier, Lucas Stüwe, Christian Böhm, Stefan Jockenhoevel, Ulrich Steinseifer, Willi Jahnen-DechentA miniaturized biohybrid material testing system, compatible with live cells, that […]Aaron D. Morgan
- An integrated valved microfluidic platform for rapid and simultaneous nucleic acid detection December 17, 2025Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01096A, PaperZihan Wang, Fuwan Yang, Shuai Zeng, Rui Sun, Qifei Hu, Yichen DuAn integrated valved microfluidic device was developed combining RPA, CRISPR, and lateral flow for nucleic acid detection. With pre-lyophilized reagents and simple valve operation, it achieves 20-copy sensitivity for HPV16/18 detection.To cite this article before page numbers are […]Zihan Wang
- Enabling the recirculation of leukocytes in a high-throughput microphysiological system (MPS) to study immune cell-vascular tissue interactions January 6, 2026
