RSC – Lab Chip latest articles- Dynamic Fluidic Manipulation in Microfluidic Chips with Dead-End Channels Through Spinning: The Spinochip Technology for Hematocrit Measurement, White Blood Cell Counting and Plasma Separation January 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00979G, PaperCemre Oksuz, Can Bicmen, Huseyin Cumhur TekinCentrifugation is crucial for size and density-based sample separation, but low-volume or delicate samples suffer from loss and impurity issues during repeated spins. We introduce the "Spinochip," a novel microfluidic...The content of this RSS Feed (c) The Royal Society of ChemistryCemre Oksuz
- Retina-on-Chip: Engineering Functional in vitro Models of the Human Retina using Organ-on-Chip Technology January 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00823E, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tarek Gensheimer, Devin Veerman, Edwin Meine Van Oosten, Loes Segerink, Alejandro Garanto, Andries D. van der MeerThe retina is a complex and highly metabolic tissue in the back of the eye essential for […]Tarek Gensheimer
- Microfluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions January 14, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00824C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mohammadhassan Ansarizadeh, Hoang-Tuan Nguyen, Bojana Lazovic, Jere Kettunen, Laknee De Silva, Ragul Sivakumar, Pauliina Junttila, Siiri-Lisa Rissanen, Ryan Hicks, Prateek Singh, Lauri EklundA novel microfluidic platform was designed to study the cellular architecture of […]Mohammadhassan Ansarizadeh
- An integrated paper-based microfluidic platform for screening of early-stage Alzheimer's disease by detecting Aβ42 January 13, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00748D, PaperSixuan Duan, Tianyu Cai, Lizhe Chen, Xiaoyan Wang, Shuailong Zhang, Bing Han, Eng Gee Lim, Kai Hoettges, Yong Hu, Pengfei SongA single rotary-valve assisted paper-based immunoassay device (RAPID) for early screening of Alzheimer's disease (AD), enables fully automated and efficient detection of the AD biomarker.To cite this article before […]Sixuan Duan
- Geometry of obstructed pathway regulates upstream navigational pattern of sperm population January 13, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00797B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ali Karimi, Mohammad Yaghoobi, Alireza AbbaspourradSperm navigation through the complex microarchitecture of the fallopian tube is essential for the successful fertilization. Spatiotemporal structural alteration due to folded epithelium or the muscle contractions in the […]Ali Karimi
- Selective adsorption of unmethylated DNA on ZnO nanowires for separation of methylated DNA January 10, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00893F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marina Musa, Zetao Zhu, Hiromi Takahashi, Wataru Shinoda, Yoshinobu Baba, Takao YasuiThis study presents a ZnO nanowire-based microfluidic device that collects methylated DNA by selectively capturing unmethylated DNA, providing a simple and efficient method […]Marina Musa
- A single droplet dispensing system for high-throughput screening and reliable recovery of rare events January 10, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00536H, PaperMarian Weiss, Sadat Hasan, Robert Genth, Mohammad Mollah, Elea Robert, Alejandro Gil, Lars HufnagelMicrofluidic droplet sorting has emerged as a powerful technique for a broad spectrum of biomedical applications, ranging from single cell analysis and high-throughput drug screening to biomarker detection and tissue...The content of this RSS Feed (c) […]Marian Weiss
- Microfluidics for morpholomics and spatial omics applications January 10, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00869C, Perspective Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nishanth Venugopal Menon, Jeeyeon Lee, Tao Tang, Chwee Teck LimCreative designs, precise fluidic manipulation, and automation have supported the development of microfluidics for single-cell applications. Together with the advancements in detection technologies and artificial […]Nishanth Venugopal Menon
- Time-resolved single-cell secretion analysis via microfluidics January 10, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00904E, Critical ReviewYing Xu, Mei Tsz Jewel Chan, Ming Yang, Heixu Meng, Chia-Hung ChenInnovative microfluidic devices are essential for tracking single-cell secretion over time, enabling a deeper understanding of cell state transitions and molecular activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Ying Xu
- Microsensor systems for cell metabolism – from 2D culture to organ-on-chip (2019–2024) January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00437J, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Johannes Dornhof, Jochen Kieninger, Stefan J. Rupitsch, Andreas WeltinWe review the latest developments in microsensor systems for monitoring the metabolism of cell cultures and organs-on-chip, including sensor principles, requirements, performance, notable achievements, and […]Johannes Dornhof
- Advances in microfluidic platforms for tumor cell phenotyping: from bench to bedside January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00403E, Critical ReviewRutwik Joshi, Hesaneh Ahmadi, Karl Gardner, Robert K. Bright, Wenwen Wang, Wei LiHeterogeneities among tumor cells significantly contribute towards cancer progression and therapeutic inefficiency. Herein, we discuss recent microfluidic platforms for sorting and profiling of tumor cells for prognostics and personalized therapies.To cite this article before page numbers […]Rutwik Joshi
- Droplet microfluidics: unveiling the hidden complexity of the human microbiome January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00877D, Critical ReviewYibin Xu, Zhiyi Wang, Caiming Li, Shuiquan Tian, Wenbin DuThe human microbiome is vital for health. Droplet microfluidics offers a versatile toolbox for microbiome research, enabling single-cell sequencing, cultivation, and functional analyses to deepen our understanding and drive innovations.To cite this article before page numbers are assigned, use […]Yibin Xu
- Challenges in blood fractionation for cancer liquid biopsy: how can microfluidics assist? January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00563E, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Robert Salomon, Sajad Razavi Bazaz, Kirk Mutafopulos, David Gallego-Ortega, Majid Warkiani, David Weitz, Dayong JinMicrofluidic blood fractionation has a critical role in enhancing liquid biopsy. Liquid biopsy allows molecular and phenotypic characteristics of […]Robert Salomon
- Developing 3D bioprinting for organs-on-chips January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00769G, Critical ReviewZhuhao Wu, Rui Liu, Ning Shao, Yuanjin ZhaoOrgans-on-chips (OoCs) can be directly fabricated by 3D bioprinting techniques, which enhance the structural and functional fidelity of organ models and broaden the applications of OoCs.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Zhuhao Wu
- Particle manipulation under X-force fields January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00794H, Critical ReviewChundong Xue, Yifan Yin, Xiaoyu Xu, Kai Tian, Jinghong Su, Guoqing HuThis review highlights recent technological advances for progress in particle manipulation under X-force fields, and forecasts the trajectory of future developments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Chundong Xue
- Aptamer selection via versatile microfluidic platforms and their diverse applications January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00859F, Critical ReviewYi-Da Chung, Yi-Cheng Tsai, Chi-Hung Wang, Gwo-Bin LeeThis review examines contributions of microfluidic technology to SELEX-based aptamer identification, with alternative methods such as in vivo-like SELEX and Non-SELEX for selecting aptamers and discussed critical SELEX steps over the past decade.To cite this article before page numbers are assigned, […]Yi-Da Chung
- Micro- and milli-fluidic sample environments for in situ X-ray analysis in the chemical and materials sciences January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00637B, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark A. Levenstein, Corinne Chevallard, Florent Malloggi, Fabienne Testard, Olivier TachéWe review the application of micro- and milli-fluidic devices for in situ X-ray scattering, spectroscopy, and imaging in the physical sciences. In particular, […]Mark A. Levenstein
- Sample-to-answer microfluidic device towards the point-of-need detection of Staphylococcus aureus enterotoxin genes in ruminant milk January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00907J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maha Shalaby, Valentina Busin, Xiaoxiang Yan, Seyda Cengiz, Mehmet Cemal Adiguzel, Jonathan M. Cooper, Taya Forde, Julien ReboudWe developed a sample-to-answer point-of-need molecular test for detecting bacteria toxin genes in milk, integrating a simple […]Maha Shalaby
- Demystifying EV heterogeneity: emerging microfluidic technologies for isolation and multiplexed profiling of extracellular vesicles January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00777H, Critical ReviewGuihua Zhang, Xiaodan Huang, Sinong Liu, Yiling Xu, Nan Wang, Chaoyong Yang, Zhi ZhuThe microfluidic-based technique that combines efficient isolation of EVs and multiple detection of EV cargos like proteins, nucleic acids, and glycans at bulk, single/single cell level to further demystify EV heterogeneity.To cite this article before […]Guihua Zhang
- Droplets in open microfluidics: generation, manipulation, and application in cell analysis January 8, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00646A, Tutorial ReviewJiaxu Lin, Ying Hou, Qiang Zhang, Jin-Ming LinThis review focuses on droplets in open microfluidics, covering their generation, manipulation and application in cell analysis. It could serve as a comprehensive guide for readers to understand and explore open droplet systems.To cite this article before page numbers are assigned, […]Jiaxu Lin
- Dynamic Fluidic Manipulation in Microfluidic Chips with Dead-End Channels Through Spinning: The Spinochip Technology for Hematocrit Measurement, White Blood Cell Counting and Plasma Separation January 15, 2025
