RSC – Lab Chip latest articles- Microfluidic-Assisted Sperm Sorter: A High-Throughput Sperm Selection Device November 19, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00734H, PaperDhiraj B Puri, Vadiraj Hemadri, Gautam Biswas, Siddhartha TripathiInfertility affects millions of people around the world, making it a significant health issue. The success of Assisted Reproductive Techniques (ART) largely depends on quality and method used for sperm...The content of this RSS Feed (c) The Royal Society of ChemistryDhiraj B Puri
- Multifunctional microfluidic bioelectronic suture for accelerated healing and wound monitoring November 19, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00880H, PaperYesol Kim, Chanhui Park, Gi Doo Cha, Sung-Hyuk Sunwoo, Dae-Hyeong KimA multifunctional microfluidic bioelectronic suture enables real-time wound monitoring and electrical stimulation to accelerate healing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Yesol Kim
- Engineering Spatially Defined Extracellular Matrix Gradients to Govern Self-Organized Multicellular Aggregates in a Glioblastoma-on-a-Chip November 18, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC01018G, PaperJianing Li, Xinghua Gao, Xiaoling Yang, Hongcai Wang, Xindi Sun, Chang Xue, Jingyun MaThe spatial heterogeneity of biochemical cues within the tumor microenvironment (TME) critically influences cancer progression and therapeutic resistance. However, existing models often lack the capacity to generate stable, quantitative concentration...The content of this RSS Feed (c) […]Jianing Li
- Carbonate reservoir surface-mimicking platform for CO₂-seawater-concrete flooding November 18, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00775E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Abhishek Ratanpara, Daniel Guerrero, Diana Cho, Abhishek ., Adib Mahmoodi Nasrabadi, Myeongsub Mike KimMicrofluidic platforms are increasingly used in enhanced oil recovery (EOR) studies due to their ability to visualize and control fluid displacement […]Abhishek Ratanpara
- Multi-zone patterning enables hematocrit-independent, precision metering of dried plasma for decentralized diagnostics November 17, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00844A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Amanda Code, Giorgio Gianini Morbioli, Keith R. Baillargeon, Jack Soloway, Yanran Sun, Charles R. MaceThere has been a notable increase in decentralized sample collection to facilitate diagnostic testing or wellness screening conducted by clinical […]Amanda Code
- Application of a bioengineered intestinal epithelium for drug permeability and metabolism studies November 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00626K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elisabeth Gill, Stephanie Muenchau Schoepp, Sina Simon, Marius F. Harter, Mikhail Nikolaev, Iago Pereiro, Inês Silva, Rubén López-Sandoval, Marco Berrera, Tony Kam-Thong, Marco Michalski, Michael Zaayman, Julien Aubert, Irineja Cubela, Janneke Keemink, Cordula Stillhart, […]Elisabeth Gill
- Mechanobiological Regulation of T Cells via Transient Viscoelastic Microfluidic Confinement November 17, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00833F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mohammad Asghari, Morteza Aramesh, Prerit Mathur, Yingchao Meng, Margherita Bernero, Viola Vogel, Stavros Stavrakis, Andrew deMelloT cell migration through confined spaces, such as venular blood vessel walls or tumor tissues, is crucial for delivering […]Mohammad Asghari
- Realization of rapid diabetic retinopathy screening with lipocalin 1 in tear using enhanced immunofluorescence photonic crystal microchip November 14, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00919G, PaperKullaphat Nitayachat, Dhrubajyoti Das, Pei-Yi Chen, Sheng-Min Hsu, Jhih-Cheng Wang, Han-Sheng ChuangA portable lateral-flow microfluidic chip integrated with a photonic crystal biosensor that enhances immunofluorescence, enabling sensitive detection of diabetic retinopathy from human tear samples using lipocalin-1 as a biomarker.To cite this article before page numbers are assigned, use […]Kullaphat Nitayachat
- Oxygen-free discontinuous dewetting in a degassed mold for anisotropic colloidal hydrogel microparticle synthesis November 14, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00928F, PaperJiwoo Kim, Jun Hee Choi, Jeongmin Kim, Jihyun Kim, Yoon Ho Roh, Ki Wan BongWe develop oxygen-free discontinuous dewetting in a degassed mold for anisotropic colloidal hydrogel microparticle synthesis. By eliminating oxygen from the reactants, we achieve fabrication of particles with feature sizes as small as 600 nm.To cite […]Jiwoo Kim
- Sol–gel coating-derived liquid marbles as highly efficient micro-photobioreactors for cyanobacterial cultivation November 13, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00759C, PaperMei Duan, Wenjun Tian, Xianglong Pang, Rongtao Li, Junjie Wang, Xinxin Cui, Lingao Yang, Xiaoguang LiMonolayer nanoparticle-coated liquid marbles (mNPc LMs) are developed to serve as micro-photobioreactors (PBRs), exhibiting superiority over conventional PBRs for cyanobacterial cultivation.To cite this article before page numbers are assigned, use the DOI form of […]Mei Duan
- Cement-on-a-chip: a microreactor for operando studies of the carbonation curing of cementitious materials November 13, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00638D, PaperValentin Hérault, Eddy Foy, Émeline Charon, Gaëtan Touzé, Céline Cau Dit Coumes, Stéphane Poyet, Corinne Chevallard, Mark A. LevensteinWe report the first miniaturized device for studying cement curing, enabling operando measurements and higher experimental throughput than previously possible.To cite this article before page numbers are assigned, use the DOI […]Valentin Hérault
- Use of poly(glycerol sebacate) as an alternative to poly(dimethylsiloxane) as a platform for making micro-fluidic channels November 13, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00851D, PaperYasmeena Ashraf, Animangsu GhatakPoly(dimethylsiloxane) (PDMS) has been used extensively for making microfluidic devices because of several favorable features: optical transparency, bio-compatibility, easy moldability and its inertness towards most materials.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Yasmeena Ashraf
- High frequency acoustofluidic based controllable drug delivery system November 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00771B, PaperRui You, Shuting Pan, Yuan Ning, Hongxiang Zhang, Tiechuan Li, Bo Long, Dapeng Ye, Xuexin DuanHerein, we report a GHz acoustofluidic-based implantable drug delivery system (GADDS) that leverages nanochannel-based molecular diffusion and acoustic streaming effect-based release modulation for controllable drug delivery.To cite this article before page numbers are assigned, […]Rui You
- Dual-channel six-step linear concentration gradient microfluidic chip for orthogonal combination drug screening in head and neck tumor cells November 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00572H, PaperJingru Liao, Zhimi Zhang, Guiquan Zhu, Dan Liu, Zhihao Tu, Wangang Zhu, Tao Dong, Ling Li, Zhuqing WangA dual-channel microfluidic chip generates stable six-step drug gradients for head and neck tumor organoids, enabling rapid, low-cost, and precise combination drug screening with results matching conventional assays.To cite this article before […]Jingru Liao
- A microfluidic chip recapitulating the human neurovascular unit with a functional blood–brain barrier for modeling gut–brain interactions November 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00937E, PaperWenxin Wang, Jingwei Cui, Yufei Guo, Xuesong Kang, Hong Liu, Zikai HaoA human neurovascular unit chip recreates a functional blood–brain barrier and reveals how gut microbial metabolites modulate brain neurotransmitter metabolism.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Wenxin Wang
- An integrated microfluidic system with shear force control for automatically modified mRNA display technique for screening high-specificity peptide probes November 12, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00914F, PaperHao-Yen Wang, Shih-Yu Shen, Lily Hui-Ching Wang, Gwo-Bin LeeWe developed a low-cost, integrated microfluidic system (IMS) featuring micropumps, microvalves, micromixers, and thermoelectric modules that, for the first time, fully automated the modified-mRNA display technique for the screening of...The content of this RSS Feed (c) The Royal Society of ChemistryHao-Yen Wang
- Microfluidic analysis of salt-stress-mediated antibiotic tolerance in Mycobacterium smegmatis November 11, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00713E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Akanksha Agrawal, Dhananjay Udaya Kumar, Raju Mukherjee, Dileep MampallilUnderstanding how bacteria respond to complex environmental stresses is essential for addressing antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form […]Akanksha Agrawal
- Engineering osteoclast resorption units via sacrificial microgels in a bone-on-chip platform November 11, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00682A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francisco Conceição, Nuno Araújo-Gomes, Johanna F. A. Husch, Malin Becker, Jeroen J. J. P. van den Beucken, Jeroen Leijten, Liliana Moreira TeixeiraA bone-on-chip model integrating encapsulated osteoclasts within biomimetic mineralized collagen was established to […]Francisco Conceição
- Reversible and reusable compartmentalized thermoplastic chip for coculture of dorsal root ganglion neurons November 11, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00666J, PaperSolène Moreau, Raul Flores-Berdines, Anne Simon, Tatiana El Jalkh, Guillaume Taret, Anna Fomina, Céline Dargenet-Becker, André Estevez-Torres, Sophie Bernard, Hugo SalmonA reusable, reversibly bonded, thermoplastic chip and its life cycle analysis for dorsal root ganglia compartmentalized culture for modeling the peripheral nervous system.To cite this article before page numbers […]Solène Moreau
- Advancing Liquid Biopsy: Whispering Gallery Mode Laser Detection of HER2 on Extracellular Vesicles November 10, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00269A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sentayehu Fetene Wondimu, Richa Khanduri, John Atanga, Marc Hippler, Andreas Hofmann, Christoph Hussal, Daria Kohler, Sarah Kraemer, Uwe Bog, Tobias Wienhold, Meike Koenig, Sebastian Köber, Timo Mappes, Heinz Kalt, Jörg Lahann, Wolfgang Freude, Johnathan […]Sentayehu Fetene Wondimu
- Microfluidic-Assisted Sperm Sorter: A High-Throughput Sperm Selection Device November 19, 2025
