RSC – Lab Chip latest articles- Polyarginine-functionalized AP site probes for mechanistic analysis of uracil-DNA glycosylase via nanopore-based single-molecule sensing June 25, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00388A, PaperTing Li, Shaojiao Song, Wei Lu, Xin Zheng, Hui Tian, Yu Cao, Qiuyue Zhao, Hongying Xie, Jiexin Ita Zheng, Hailong WangThe interaction between abasic (apurinic/apyrimidinic, AP) sites and aberrant uracil DNA glycosylase (UDG) contributes to cancer progression, establishing AP site recognition and UDG detection as critical tools for bioanalytical […]Ting Li
- Spheroid-based skin-on-a-chip platform for the evaluation of the toxicity of small molecules and nanoparticles June 25, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00311C, PaperDianoosh Kalhori, Faeze Rakhshani, Yingshan Ma, Ilya Yakavets, Sina Kheiri, Ophelie Zeyons, Susanne N. Kolle, Ted Deisenroth, Liangliang Echo Qu, Zhengkun Chen, Eugenia KumachevaExposure of human skin to chemical agents may lead to skin sensitization, irritation, and corrosion. Time-efficient toxicity screening can be achieved using in vitro skin-on-a-chip models, […]Dianoosh Kalhori
- Statistical distribution of elevation from a planar interface of phoretically active microparticles June 24, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC01092B, PaperFabian Rohne, Daniela Vasquez Munoz, Isabel Meier, Nino Lomadze, Svetlana Santer, Marek BekirIn this article, we study the height distribution of phoretically active microparticles exposed to external flow. Sedimented particles hover under light illumination and experience a stronger shear force proportional to...The content of this RSS Feed (c) The […]Fabian Rohne
- Orientation-independent bubble trap with internal partition for robust operation of microfluidic systems June 22, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC01060D, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bhavagyna Vegunta, Charmaine Lui, Max Kim, Joshua Tran, Maya Papez, Anand K. Ramasubramanian, Sang-Joon John LeeThe bubble trap has a spherical cavity and a partition with internal passages. Ingress and egress ports near the […]Bhavagyna Vegunta
- Portable platform for measuring amyloid beta 42/40 ratio via photooxidation-induced fluorescence amplification June 22, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00235D, PaperSanghag Ko, Hyunjun Bae, Daewon Kim, Yeonju Lee, Isaac Choi, Dain Lee, Dong hwan Choi, Hyung Chul Kim, Seo Young Sohn, Yohan Jeong, Seok Chung, Young Hee JungWe developed a portable immunoassay platform using photooxidation-induced fluorescence amplification to measure Aβ 42/40 in plasma, offering a more accessible alternative to […]Sanghag Ko
- Micro-/Nanoparticle Separation Combining Inertial and Thermophoretic Effects in Three-dimensional Serpentine-Spiral Channels June 19, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00420A, PaperJunho Kim, Hwisu Jeon, Kyunghun Lee, Taesung KimThe separation of micro-/nanoparticles on a chip is an important research area with significant applications in biology, biomedical engineering, and materials science. However, separation mechanisms that are effective for microparticles...The content of this RSS Feed (c) The Royal Society of ChemistryJunho Kim
- Advancing sustainable energy solutions with microfluidic porous media June 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00206K, Critical ReviewWenhai Lei, Yuankai Yang, Shuo Yang, Ge Zhang, Jenna Poonoosamy, Anne Juel, Yves Méheust, Shervin Bagheri, Moran WangMultiphase reactive flow in sustainable energy solutions (CCS, UHS, NWGD), coupling the multiphase flow, reactive transport, and microbial activities. The internal schematic diagram is the subsurface storage of CO2, H2, and […]Wenhai Lei
- Analysis of and methods for void-free liquid filling of blind microchambers in centrifugal microfluidics June 16, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00323G, PaperWeiyao Ni, Yi Gao, Enming Cui, Yifei Li, Yangyang Wang, Yahua Liu, Yi Li, Mengxi Wu, Junshan LiuTapered microchannels modify the gas–liquid flow to the annular regime, enabling void-free filling of blind microchambers without the need for complex treatments or external forces.To cite this article before page numbers are […]Weiyao Ni
- Functional screening of antibody-secreting cells by co-culture with reporter T cells using PicoShells June 15, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00319A, PaperKazuki Nishimoto, Rajesh Ghosh, Mark van Zee, Darren Fang, Zhiyuan Mao, Miyako Noguchi, Dino Di CarloAntibody secreting cells (ASCs) and reporter T cells are co-cultured in PicoShells, hollow hydogel particles. T cell-activating antibodies are identified via reporter signals using standard FACS, enabling recovery of high-functioning ASCs.To cite this article […]Kazuki Nishimoto
- Vascular microphysiological systems (MPS): biologically relevant and potent models June 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00014A, Critical ReviewLucas Breuil, Atsuya Kitada, Sachin Yadav, Hang Zhou, Kazuya Fujimoto, Ryuji YokokawaExtensive research focused on the vasculature, aiming to understand its structural characteristics, functions, interactions with surrounding tissues, and the mechanisms underlying vascular-related pathologies. However, advancing our understanding of vascular biology...The content of this RSS Feed (c) The […]Lucas Breuil
- Mammalian cell culture and analysis in digital microfluidic platforms June 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00250H, Tutorial Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Burcu GumuscuThis tutorial review covers mammalian cell culture integration within digital microfluidic devices, exploring scaffolds, AC/DC effects on cell behavior, physical/biochemical stimuli delivery, on-chip analytics, sorting, and organ-on-chip aspects.To cite this article before […]Burcu Gumuscu
- Impact of multiphasic pore-scale interactions on gas hydrate formation and dissociation characteristics and kinetics: a microfluidic study June 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00093A, PaperYuze Wang, Jianyu Yang, Pengfei Wang, Jinlong Zhu, Yongshun John ChenMicrofluidic observation with methylene blue enhanced gas–water–hydrate phase distinction, revealing five hydrate morphologies shaped by multiphase interactions and showing that gas contact significantly accelerates hydrate dissociation.To cite this article before page numbers are assigned, use the DOI form of […]Yuze Wang
- Droplet microfluidics integrated with machine learning reveals how adipose-derived stem cells modulate endocrine response and tumor heterogeneity in ER+ breast cancer June 12, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00320B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Braulio Andrés Ortega Quesada, Calley Chauvin, Elizabeth Martin, Adam MelvinAbout 40% of breast cancer patients treated with endocrine therapy develop resistance at some point. It is suspected that stromal cells and cell heterogeneity play […]Braulio Andrés Ortega Quesada
- A microfluidic platform for studying supercritical fluid crystallization and its applications June 11, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC01032A, PaperFatma Ercicek, Arnaud Erriguible, Olivier Nguyen, Christelle Harscoat-Schiavo, Pascale Subra-Paternault, Samuel MarreA HP microfluidic set-up coupled with in situ Raman spectroscopy for monitoring CO2-cosolvent diffusion and studying supercritical anti-solvent crystallization. This approach allows rapid screening for discovering new organic co-crystals.To cite this article before page numbers are assigned, use […]Fatma Ercicek
- A disease-inspired in vitro model of aortic valve stenosis to investigate the drivers of endothelial–mesenchymal transition June 10, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00484E, PaperYasmin Mirzaalikhan, Austin Lai, Manijeh Khanmohammadi, Chanly Chheang, Azadeh Mirabedini, Shadi Houshyar, Jonathan Noonan, Anna M. D. Watson, Nalin Dayawansa, Silvana Marasco, Karlheinz Peter, Sara BaratchiA biomimetic hydrogel model of CAVD reveals that hyaluronic acid-rich ECM and reduced stretch synergistically drive EndMT and inflammation, highlighting biomechanical and matrix cues […]Yasmin Mirzaalikhan
- Fast capillary flow on μPADs with hollow channels packaged by a thermal contraction tube June 10, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00086F, PaperXinyi Chen, Haonan Li, Xionghui Li, Muyang Zhang, Qinghao He, Jie Zhou, Jiahua Zhong, Hao Chen, Yixi Shi, Huilin Chen, Huiru Zhang, Lok Ting Chu, Weijin GuoThis work presents a novel μPAD packaging method using thermal contraction tubes to create hollow channels, significantly enhancing capillary flow rates (up to […]Xinyi Chen
- High frequency capillary wave-enabled ultra-small droplets for inhaled drug delivery June 10, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00390C, PaperHaitao Zhang, Zirui Zhao, Yangchao Zhou, Zaoxian Mei, Xuexin DuanA gigahertz-acoustic-wave-based portable nebulizer is introduced for more efficient drug delivery via inhalation. By integrating a bulk acoustic resonator and microchannel, near-monodisperse aerosols with tunable sizes are generated.To cite this article before page numbers are assigned, use the DOI form […]Haitao Zhang
- Hybrid GC platform: a micro gas chromatography system with a simple configuration for low-concentration VOC analysis June 9, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00268K, PaperYeongseok Lee, Sangkyun Lee, Woojin Jang, Junwoo Lee, Yuntaek Choi, Si-Hyung LimA hybrid GC platform was developed with a simple configuration, a small volume, and analysis performance applicable to VOC monitoring.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Yeongseok Lee
- Outstanding Reviewers for Lab on a Chip in 2024 June 9, 2025Lab Chip, 2025, 25,3037-3037DOI: 10.1039/D5LC90059J, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Lab on a Chip in 2024, as selected by the editorial team for their significant contribution to the journal.The content of this RSS Feed (c) The Royal Society of Chemistry
- Point-of-care analysis for foodborne pathogens in food samples based on a fully enclosed microfluidic chip cartridge June 9, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00819G, PaperDayun Tang, Peng Li, Shuo Qi, Qiong Wu, Ruili Yu, Mei Liu, Zhouping WangA fully automated detection device based on a fully enclosed microfluidic chip cartridge was successfully designed for the detection of foodborne pathogenic microorganisms.To cite this article before page numbers are assigned, use the DOI form of […]Dayun Tang
- Polyarginine-functionalized AP site probes for mechanistic analysis of uracil-DNA glycosylase via nanopore-based single-molecule sensing June 25, 2025
