RSC – Lab Chip latest articles- Topology-Based Coordination Control for Multi-Droplet Tasks in Autonomous Digital Microfluidics April 8, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00147E, PaperZhen Gu, kunlun guo, Zerui Song, Boyi Feng, Tiaofen Qiu, Jiale Zhou, Bin Shen, Bingyong Yan, Hui-Feng WangDigital microfluidics (DMF) is a versatile technique for parallel and field-programmable control of individual droplets. The challenge of large-scale parallel droplet manipulation in DMF is essentially a cross-scale complex system...The content of […]Zhen Gu
- Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood April 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00039H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lewis Krzeczkowski, Georgios Nteliopoulos, Simak Ali, Paul Davey, R. Charles Coombes, Ali Salehi-ReyhaniA microfluidic band-stop filter selectively enriches viable CTC-sized cells from undiluted whole blood while excluding smaller and larger blood cells. Captured cells […]Lewis Krzeczkowski
- High-Throughput Microfluidic Platform for Modelling Inflammatory Responses of Human Articular Chondrocytes under Variable Fluid Shear Stress April 7, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01167A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aldeliane Maria da Silva, Priscila C Rodrigues, Meriem Lamghari, Hoang-Tuan Nguyen, Jere Kettunen, Sebastien Mosser, Prateek Singh, Ali Mobasheri, Gabriela LoriteInflammation plays a critical role in osteoarthritis (OA), a debilitating joint disease characterized by […]Aldeliane Maria da Silva
- Correction: Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays April 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC90032A, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ali Khademhosseini, Judy Yeh, George Eng, Jeffrey Karp, Hirokazu Kaji, Jeffrey Borenstein, Omid C. Farokhzad, Robert LangerTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Ali Khademhosseini
- Robotic acoustofluidic single-cell picking and placement platform April 7, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01129A, PaperWanqi Li, Qiu Yin, Jiahui Wu, Chenfan Zhang, Xiaochen Li, Chenyang Zhou, Xianting Ding, Xiang ChenSingle-cell manipulation is essential for investigating cellular heterogeneity and enabling downstream assays, such as single-cell proteomics and drug screening.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Wanqi Li
- A dual-antibody gold nanoparticle-based lateral flow assay for rapid and selective detection of mesenchymal stem cell stemness April 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00037A, PaperDrishya Prakashan, C. A. Amarnath, Shilpa N. Sawant, G. Taru Sharma, Sonu GandhiSmartphone readable AuNPs-LFA enables rapid, visual, and qualitative detection of stemness of MSCs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]Drishya Prakashan
- Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells April 6, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00067C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Louis P Widom, Panteha Torabian, Michelle A Trempel, Molly C McCloskey, Lea Vacca Michel, James L McGrath, Thomas R. GaborskiPathogenic bacterial extracellular vesicles (BEVs) can disrupt the blood-brain barrier (BBB), leading to neuroinflammation. Prior […]Louis P Widom
- Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva April 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01063B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ling Ding, Huizi Zhang, Yao Li, Jun KameokaA stitched lyocell–modal microfluidic platform guides saliva to a microneedle-based electrochemical sensor, providing a simple route for low-concentration lactate detection in human saliva.To cite this article before […]Ling Ding
- Cap-Sweat: a capillary microfluidic platform for digitized sweat sampling and time-resolved biomarker analysis April 6, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01172H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pezhman Jalali, Amir Sanati NezhadWearable capillary device for time-resolved sweat analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Pezhman Jalali
- An automated modular microfluidic platform for end-to-end mRNA synthesis and purification April 5, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00118A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vikas Sharma, Amirreza Mottafegh, Jeong-Un Joo, Dong-Pyo KimManual, batchwise downstream operations remain a major bottleneck in translating microfluidic mRNA synthesis into practical production workflows. Building on an oscillatory microfluidic IVT module (Os(IVT)) previously established […]Vikas Sharma
- Flow-Programmable and Reversible Surface-Induced LLPS in Nanofluidic Channels April 2, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00003G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryoichi Ohta, Zhixin Zhao, Xuan Yan, Ruying Wang, Kazuma MawatariLiquid–liquid phase separation (LLPS) functions as a high-performance reactor strategy in cells, creating dynamic "membrane-less organelles" that selectively concentrate biomolecules. Mimicking this volumetric strategy on […]Ryoichi Ohta
- Compact Superlattice as Label-free Surface-Enhanced Raman Scattering Substrate for Noninvasive Urine Test in the Diagnosis of Lung Cancer April 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01177A, PaperKaili Zhang, Yuancai Ge, Yi Xu, Yujie Liu, Chaoyue Cui, Yuxin Liang, Yangxuan Lin, Jungeng Zhang, Qingwen Zhang, Yi Wang, Xiaoming LinThe development of noninvasive cancer diagnosis may provide the convenience of remote painless diagnosis, instant healthcare and postoperative follow-up. Label-free surface-enhanced Raman spectroscopy (SERS) is becoming as a […]Kaili Zhang
- Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting April 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00072J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alison Skelley, Yasna Behmardi, Luke Peterson, David Inglis, Mabel Shehada, Laurissa Ouaguia, Khushroo Gandhi, Roberto Campos-González, Tony WardAutologous CAR-T cell therapy has demonstrated remarkable clinical efficacy in hematologic malignancies, yet its broader application remains […]Alison Skelley
- Numerical microfluidic chip modeling of laminar vortex dynamics induced by biomineralization in evolving porous media April 1, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01002K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yajie Chu, Dianlei FengNaturally evolving porous media, such as those undergoing mineral precipitation, biofilm growth, and freeze-thaw cycling, dynamically alter pore structure, inducing vortices that influence mass transport and mixing. Yet, due to...The content […]Yajie Chu
- Low-temperature inkjet-printed electrochemical sensors on OSTE+ microfluidics for oxygen monitoring and scavenging April 1, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01117E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Denise Marrero, Ferran Pujol-Vila, Eva Tuset, Gemma Gabriel, Rosa Villa, Mar Alvarez, Xavi IllaPhotonic curing sinters gold and silver nanoparticle inks without damaging polymer substrates. Real-time oxygen scavenging is monitored using electrochemical sensors. Tunable […]Denise Marrero
- Integration of continuous microfluidic electrokinetic bioparticle preconcentration with programmable extraction into a discrete microfluidic platform March 30, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00647C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amir Hillman, Sinwook Park, Gilad YossifonIon concentration polarization-based electrokinetic molecular preconcentration in a flowing microchannel, followed by electrowetting-on-dielectric extraction into discrete droplets within an integrated continuous-digital microfluidic platform.To cite this article before page numbers […]Amir Hillman
- A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks March 29, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01171J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Delaney Gray-Scherr, Terry Ching, Katherine Beran, Sarah C. Adams, Emily Davis, Abraham C. I. van Steen, Trisha Raman, Wilson W. Wong, Jeroen Eyckmans, Christopher S. ChenA 3D microfluidic platform for studying cross-network transport and […]Delaney Gray-Scherr
- A 3D-Printed Electromagnetically Actuated Microgripper System for Precision Single-Cell Manipulation March 27, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00081A, PaperXi Chen, Qingying Ren, Wenshuo Zhao, Minhao Wang, Yining Guo, Jing Huang, Xuhui Zhao, Xinyu Lu, Yuan Liu, Haifeng XuCell manipulation is an important technique in biomedical research, yet existing micromanipulation tools still face challenges in force-control precision, multiscale adaptability, and biocompatibility. To address these limitations, this paper presents...The […]Xi Chen
- Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions March 26, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01094B, PaperYue Yu, Tian Lin, Xiao Ye, Yupeng Wang, Rong-Rong Xiao, Baiyang Sun, Manman Zhao, Jie Song, Bo Li, Xiaobing ZhouCurrent preclinical models face challenges in recapitulating organ-level interactions affecting drug safety and there has been little investigation into drug toxicity and related DILI. We presented a pump-less gut-liver-on-chip enabling...The […]Yue Yu
- Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations March 25, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01042J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Esra Yilmaz, Zhimeng Fan, Jason Paul Beech, Vinay Swaminathan, Jonas Olof TegenfeldtCancer cells display marked heterogeneity in size and morphology, traits long recognized in pathology as indicators of pleomorphism and poor prognosis. Yet, the […]Esra Yilmaz
- Topology-Based Coordination Control for Multi-Droplet Tasks in Autonomous Digital Microfluidics April 8, 2026
