RSC – Lab Chip latest articles- Stretchable impedance electrode array with high durability for monitoring of cells under mechanical and chemical stimulations December 18, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00680A, PaperAri Kim, Hong Seok ju, Han-Byeol Lee, Nae Eung LeeElectrochemical impedance spectroscopy (EIS) serves as a non-invasive technique for assessing cell status, while mechanical stretching plays a pivotal role in stimulating cells to emulate their natural environment. Integrating these...The content of this RSS Feed (c) The Royal Society of […]Ari Kim
- 3D-printed acoustic metasurface with encapsulated micro-air-bubbles for frequency-selective manipulation December 18, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00890A, PaperMiaomiao Ji, Yukai Liu, Zheng Zhang, Rui Xu, Fanyun Pan, Ya Zhang, Rouyu Su, Minghui Lu, Xiujuan Zhang, Guanghui WangA low-frequency acoustic metasurface with PDMS-stabilized microbubbles achieves stable vibration modes, precise control over micro-object aggregation, rotation, separation, and selective trajectory manipulation through frequency-tuned excitation.To cite this article before page […]Miaomiao Ji
- A universal framework for design and manufacture of deterministic lateral displacement chips December 18, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00838C, PaperAryan Mehboudi, Shrawan Singhal, S. V. SreenivasanDespite being a high-resolution separation technique, deterministic lateral displacement (DLD) technology is facing multiple challenges with regard to design, manufacture, and operation of pertinent devices. This work specifically aims at...The content of this RSS Feed (c) The Royal Society of ChemistryAryan Mehboudi
- An FET-Based Flexible Biosensor System For Dynamic Behavior Observation Of Lipid Membrane With Nanoparticles In Vitro December 18, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00801D, PaperKeyi Zhu, Hanjing Lu, Qiannan Xue, Feng Zhou, Wenlan Guo, Chen Sun, Xuexin DuanNanoparticles have become a widely used material in various fields, yet their mechanism of action at the cellular level after entering the human body remains unclear. Accurate observing the effect...The content of this RSS Feed (c) […]Keyi Zhu
- Engineering the acoustic field with a Mie scatterer for microparticles patterning December 18, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00577E, PaperXingyu Jiang, yunpeng zhao, Minjie Shen, Xiao Zhou, Bin Chen, Bruce Drinkwater, Liangfei TianThe utilization of acoustic fields offers a contactless approach for microparticle manipulation in a miniaturized system, and plays a significant role in medicine, biology, chemistry, and engineering. Due to the...The content of this RSS Feed (c) […]Xingyu Jiang
- STEPWISE ISOLATION OF DIVERSE METABOLIC CELL POPULATIONS USING SORTING BY INTERFACIAL TENSION (SIFT) December 17, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00792A, PaperMatthew Shulman, Thomas Mathew, Aria Trivedi, Azam Gholizadeh, Charlotte Colcord, Ryan Wiley, Kiron Stephen Allen, Lakshmi Thangam, Kelsey Voss, Paul AbbyadWe present here a passive and label-free droplet microfluidic platform to sort cells stepwise by lactate and proton secretion from glycolysis. A technology developed in our lab, Sorting by […]Matthew Shulman
- An agarose fluidic chip for high-throughput in toto organoid imaging December 17, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00459K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sarah De Beuckeleer, Andres Vanhooydonck, Johanna Van Den Daele, Tim Van De Looverbosch, Bob Asselbergh, Hera Kim, Coen Campsteijn, Peter Ponsaerts, Regan Watts, Winnok H. De VosCell and developmental biology increasingly relies on tissue […]Sarah De Beuckeleer
- Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell December 17, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00817K, PaperYimin Shi, Sheng Sun, Hui Liu, Mingda Zhao, Meiyan Qin, Jinlong Liu, Jingfang Hu, Yang Zhao, Mingxiao Li, Lingqian Zhang, Chengjun HuangWe introduced a spatial TEER strategy and measured the spatial TEER of the cells cultured on a Transwell. We established a new equivalent circuit model, achieving a close […]Yimin Shi
- High-throughput, combinatorial droplet generation by sequential spraying December 17, 2024Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00656A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rena Fukuda, Nate J CiraAdvancements in bulk and microfluidic emulsion methodologies have enabled highly efficient, high-throughput implementations of biochemical assays. Spray-based techniques offer rapid generation, droplet immobilization, and accessibility, but remain relatively underutilized, likely...The […]Rena Fukuda
- An intimal-lumen model in a microfluidic device: potential platform for atherosclerosis-related studies December 16, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00868E, PaperFahima Akther, Dimple Sajin, Shehzahdi S. Moonshi, Jessica Pickett, Yuao Wu, Jun Zhang, Nam-Trung Nguyen, Hang Thu TaA microfluidic early atherosclerosis intimal-lumen model for in vivo-like monocyte transmigration and foam cell formation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Fahima Akther
- A Vascularized Microfluidic Model of the Osteochondral Unit for Modeling Inflammatory Response and Therapeutic Screening. December 13, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00651H, PaperKevin D Roehm, Irene Chiesa, Dustin W. Haithcock, Riccardo Gottardi, Balabhaskar PrabhakarpandianOsteoarthritis (OA) has long been considered a disease of the articular cartilage. Within the past decade it has become increasingly clear that OA is a disease of the entire joint...The content of this RSS Feed (c) The Royal […]Kevin D Roehm
- Liquid metal electrodes enabled cascaded on-chip dielectrophoretic separation of large-size-range particles December 12, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00942H, PaperHuichao Chai, Liang Huang, Junwen Zhu, Jialu Tian, Wenhui WangThe separation of large-size-range particles of complex biological samples is critical but yet well resolved. As a label-free technique, dielectrophoresis (DEP)-based particle separation faces the challenge of how to configure...The content of this RSS Feed (c) The Royal Society of […]Huichao Chai
- Beveled microneedles with channel for transdermal injection and sampling, fabricated with minimal steps and standard MEMS technology December 12, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00880D, PaperAlvise Bagolini, Nicolò G. Di Novo, Severino Pedrotti, Matteo Valt, Cristian Collini, Nicola M. Pugno, Leandro LorenzelliMicroneedles hold the potential for enabling shallow skin penetration applications where biomarkers are extracted from the interstitial fluid (ISF) and drugs are injected in a painless and effective manner.To cite this article before […]Alvise Bagolini
- Injury-On-A-Chip for Modelling Microvascular Trauma-Induced Coagulation December 11, 2024Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00471J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Halston Deal, Elizabeth Byrnes, Sanika Pandit, Anastasia Sheridan, Ashley Brown, Michael DanieleBlood coagulation is a highly regulated injury response that features polymerization of fibrin fibers to prevent the passage of blood from a damaged […]Halston Deal
- Intelligent optoelectrowetting digital microfluidic system for real-time selective parallel manipulation of biological droplet arrays December 11, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00804A, PaperTianyi Wang, Shizheng Zhou, Xuekai Liu, Jianghao Zeng, Xiaohan He, Zhihang Yu, Zhiyuan Liu, Xiaomei Liu, Jing Jin, Yonggang Zhu, Liuyong Shi, Hong Yan, Teng ZhouAn intelligent optoelectrowetting system integrates AI-based detection and tracking to dynamically manipulate and auto-correct droplet movements. This enables precise multivariate independent microalgae cultivation in […]Tianyi Wang
- Reusable EWOD-based microfluidic system for active droplet generation December 10, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00744A, PaperSuhee Park, Jaewook Ryu, Ki-Ho HanA reusable EWOD device enables rapid, precise droplet generation, reducing costs and improving control, ideal for applications like single-cell genomics and drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Suhee Park
- Highly efficient combination of multiple single cells using a deterministic single-cell combinatorial reactor December 10, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00951G, PaperMina Yoshida, Saori Tago, Kunihiko Iizuka, Teruo Fujii, Soo Hyeon KimThis study presents a novel microfluidic device coupled with a multilayer interconnect Si/SiO2 control circuit, named the deterministic single-cell combinatorial reactor, for the highly efficient combination of multiple single cells.To cite this article before page numbers are assigned, use […]Mina Yoshida
- Correction: Distal renal tubular system-on-a-chip for studying the pathogenesis of influenza A virus-induced kidney injury December 10, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC90105C, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yueyue Huangfu, Ji Wang, Jiao Feng, Zhi-Ling ZhangTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYueyue Huangfu
- High-throughput microfluidic spheroid technology for early detection of colistin-induced nephrotoxicity with gradient-based analysis December 10, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00782D, PaperYugyeong Lee, Yunsang Choi, Ju Lan Chun, Hong Bin Kim, Sejoong Kim, Eu Suk Kim, Sungsu ParkA Spheroid Nephrotoxicity Assessing Platform (SNAP) is a microfluidic device designed to detect colistin-induced toxicity in RPTEC spheroids within 48 hours. It operates with 200 μL of patient plasma, making it suitable for […]Yugyeong Lee
- A gravity-driven microfluidic metering system for automation of multiplexed bioassays December 5, 2024Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00800F, PaperLu Zhang, Johnson Q. Cui, Shuhuai YaoOur gravity-driven microfluidic metering system enables automated multiplexed fluid metering, multistep fluid control, and multi-chamber signal readout.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryLu Zhang
- Stretchable impedance electrode array with high durability for monitoring of cells under mechanical and chemical stimulations December 18, 2024
