RSC – Lab Chip latest articles- Integrated bacterial cell lysis and DNA extraction using paper-based isotachophoresis January 27, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D3LC00604B, PaperShruti Soni, Bhushan J ToleyBacterial infections remain a global threat, particularly in low-resource settings, where access to accurate and timely diagnosis is limited. Point-of-care nucleic acid amplification tests have shown great promise in addressing...The content of this RSS Feed (c) The Royal Society of ChemistryShruti Soni
- Multi-reactive hydrogel nanovials for temporal control of secretion capture from antibody-secreting cells January 27, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC01056F, PaperMichael Patrick Mellody, Yuta Nakagawa, Richard James, Dino Di CarloAntibody discovery can benefit from techniques to screen antibody-secreting cells (ASCs) at scale for the binding and functionality of a diverse set of secreted antibodies. Previously, we demonstrated the use...The content of this RSS Feed (c) The Royal Society of […]Michael Patrick Mellody
- Synergistic Binding Ability of Electrostatic Tweezers and Femtosecond Laser-Structured Slippery Surfaces Enabling Unusual Droplet Manipulation Applications January 23, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC01084A, PaperXinlei Li, Chaowei Wang, Zhenrui Chen, Cunyuan Chen, Suwan Zhu, Dong Wu, Jiale YongWe propose a novel contactless droplet manipulation strategy that combines electrostatic tweezers (ESTs) with lubricated slippery surfaces. Electrostatic induction causes the droplet to experience an electrostatic force, allowing it to...The content of this RSS Feed (c) […]Xinlei Li
- A pumpless microfluidic co-culture system to model the effects of shear flow on biological barriers January 23, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00835A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marsel Lino, Henrik Persson, Mohammad Paknahad, Alisa Ugodnikov, Morvarid Farhang Ghahremani, Lily E Takeuchi, Oleg Chebotarev, Caleb Horst, Craig SimmonsBiological barriers formed by the endothelium and epithelium regulate nutrient exchange, disease development, and drug […]Marsel Lino
- Point-of-need diagnostics in a post-Covid world: an opportunity for paper-based microfluidics to serve during syndemics January 23, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00699B, Perspective Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria-Nefeli Tsaloglou, Dionysios C. Christodouleas, Jonathan Milette, Kendall Milkey, Isabelle C. Romine, Judy Im, Shefali Lathwal, Duraipandian Thava Selvam, Hadley D. Sikes, George M. WhitesidesA post-pandemic perspective on paper-based microfluidics by George Whitesides and […]Maria-Nefeli Tsaloglou
- Worth Your Sweat: Wearable Microfluidic Flow Rate Sensors for Meaningful Sweat Analytics January 22, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00927D, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rens Franciscus Rudolf Ursem, Annemarijn Steijlen, Marc Parrilla, Jeroen Bastemeijer, Andre Bossche, Karolien De WaelWearable microfluidic sweat sensors could play a major role in the future of monitoring health and wellbeing. Sweat contains […]Rens Franciscus Rudolf Ursem
- Large-Scale Acoustic Single Cell Trapping and Selective Releasing January 22, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00736K, PaperXiang Zhang, Jacob Smith, Amanda Chengyi Zhou, Jacqueline Thuy-Tram Duong, Tong Qi, Shilin Chen, Yen-Ju Lin, Alexi Gill, Chih-Hui Lo, Neil Y. C. Lin, Jing Wen, Yunfeng Lu, Pei-Yu ChiouRecent advancements in single-cell analysis have underscored the need for precise isolation and manipulation of individual cells. Traditional techniques for […]Xiang Zhang
- Integrating impedance cytometry with other microfluidic tools towards multifunctional single-cell analysis platforms January 22, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00957F, Critical ReviewMarta Righetto, Cristian Brandi, Riccardo Reale, Federica CaselliMicrofluidic impedance cytometry (MIC) is a label-free technique that characterizes individual flowing particles/cells based on their interaction with a multifrequency electric field. The technique has been succesfully applied in different...The content of this RSS Feed (c) The Royal Society of ChemistryMarta Righetto
- Exploring microfluidics-based organoid interactions through analysis of albumin secretion January 22, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC01085J, PaperYang Yang, Yueyang Qu, Jing Wang, Yuxiu Wang, Jiamin Zhao, Miaomiao Wang, Wanqing Hu, Jiaqi Zhao, Bingcheng Lin, Xiuli Zhang, Yong LuoOrganoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity to facilitate interactions among organoids.To cite this article before page […]Yang Yang
- Densimeter-on-Chip (DoC): measuring a single-cell mass density by sedimentation in microchannel flows January 21, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00916A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.David Dannhauser, Maria Isabella Maremonti, Paolo Netti, Filippo CausaIntrinsic biophysical and morphological features are essential for the label-free identification of different cell types. Indeed, beside the object size, density could represent a key parameter […]David Dannhauser
- Microfluidic-based redesign of a humidity-driven energy harvester January 21, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00958D, PaperHirotada Hirama, Yusuke KomazakiIntegrating microfluidic elements onto a single chip offers many advantages, including miniaturization, portability, and multifunctionality, making such systems highly useful for biomedical, healthcare, and sensing applications. However, these chips need...The content of this RSS Feed (c) The Royal Society of ChemistryHirotada Hirama
- Microfluidic Paper-based Analytical Soft Actuators (μPAC) January 20, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00602J, PaperKoki Yoshida, Masahiro Takinoue, Hiroaki Onoe, Michinao HashimotoSoft actuators have developed over the last decade for diverse applications including industrial machines and biomedical devices. Integration of chemical sensors with soft actuators would be beneficial in analyzing chemical...The content of this RSS Feed (c) The Royal Society of ChemistryKoki Yoshida
- Development and evaluation of a microfluidic human testicular tissue chip: a novel in vitro platform for reproductive biology and pharmacology studies January 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00780H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiaming Shen, Xinlong Wang, Chenghua Yang, Guanyu Ren, Lei Wang, Shuguang Piao, Boyang Zhang, Weihao Sun, Xie Ge, Jun Jing, Yijian Xiang, Zhaowanyue He, Linhui Wang, Bing Yao, Zhiyong LiuOrgan-on-a-chip culture systems using human […]Jiaming Shen
- A single microfluidic device for multi-omics analysis sample preparation January 17, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00919C, PaperRanjith Kumar Ravi Kumar, Iman Haddad, Massamba Mbacké Ndiaye, Martial Marbouty, Joëlle Vinh, Yann VerdierThe ChipFilter device is suited to prepare microorganism samples for parallel proteomic and genomic analyses, which is particularly relevant in the case of low-abundant samples and drastically reduces sampling bias.To cite this article before page […]Ranjith Kumar Ravi Kumar
- Dynamic Fluidic Manipulation in Microfluidic Chips with Dead-End Channels Through Spinning: The Spinochip Technology for Hematocrit Measurement, White Blood Cell Counting and Plasma Separation January 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00979G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cemre Oksuz, Can Bicmen, Huseyin Cumhur TekinCentrifugation is crucial for size and density-based sample separation, but low-volume or delicate samples suffer from loss and impurity issues during repeated spins. We introduce the "Spinochip," a […]Cemre Oksuz
- Retina-on-Chip: Engineering Functional in vitro Models of the Human Retina using Organ-on-Chip Technology January 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00823E, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tarek Gensheimer, Devin Veerman, Edwin Meine Van Oosten, Loes Segerink, Alejandro Garanto, Andries D. van der MeerThe retina is a complex and highly metabolic tissue in the back of the eye essential for […]Tarek Gensheimer
- Microfluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions January 14, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00824C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mohammadhassan Ansarizadeh, Hoang-Tuan Nguyen, Bojana Lazovic, Jere Kettunen, Laknee De Silva, Ragul Sivakumar, Pauliina Junttila, Siiri-Liisa Rissanen, Ryan Hicks, Prateek Singh, Lauri EklundIn-line shear stress modulation and cell microscopic analysis.To cite this article before […]Mohammadhassan Ansarizadeh
- An integrated paper-based microfluidic platform for screening of early-stage Alzheimer's disease by detecting Aβ42 January 13, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00748D, PaperSixuan Duan, Tianyu Cai, Lizhe Chen, Xiaoyan Wang, Shuailong Zhang, Bing Han, Eng Gee Lim, Kai Hoettges, Yong Hu, Pengfei SongA single rotary-valve assisted paper-based immunoassay device (RAPID) for early screening of Alzheimer's disease (AD), enables fully automated and efficient detection of the AD biomarker.To cite this article before […]Sixuan Duan
- Geometry of obstructed pathway regulates upstream navigational pattern of sperm population January 13, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00797B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ali Karimi, Mohammad Yaghoobi, Alireza AbbaspourradSperm navigation through the complex microarchitecture of the fallopian tube is essential for the successful fertilization. Spatiotemporal structural alteration due to folded epithelium or the muscle contractions in the […]Ali Karimi
- Selective adsorption of unmethylated DNA on ZnO nanowires for separation of methylated DNA January 10, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00893F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marina Musa, Zetao Zhu, Hiromi Takahashi, Wataru Shinoda, Yoshinobu Baba, Takao YasuiThis study presents a ZnO nanowire-based microfluidic device that collects methylated DNA by selectively capturing unmethylated DNA, providing a simple and efficient method […]Marina Musa
- Integrated bacterial cell lysis and DNA extraction using paper-based isotachophoresis January 27, 2025
