RSC – Lab Chip latest articles- Towards Real-Time Myocardial Infarction Diagnosis: A Convergence of Machine Learning and Ion-Exchange Membrane Technologies Leveraging miRNA Signatures October 3, 2024Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00640B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xiang Ren, Ruyu Zhou, George Ronan, S. Gulberk Ozcebe, Jiaying Ji, Satyajyoti Senapati, Keith March, Eileen Handberg, David Anderson, Carl J. Pepine, Hsueh-Chia Chang, Fang Liu, Pinar ZorlutunaRapid diagnosis of acute myocardial infarction (AMI) […]Xiang Ren
- Integrated microfluidic platform for on-site qPCR analysis: food allergen detection from sample to result October 3, 2024Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00570H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anne-Gaëlle Bourdat, Remco den Dulk, Bastien Serrano, Gervais Clarebout, Jean Porcherot, Armelle Keiser, Nicolas Sarrut, François Boizot, Xavier Mermet, Raymond Charles, Manuel Alessio, Patricia Laurent, Myriam CubizollesImproving food safety is crucial in the contexte […]Anne-Gaëlle Bourdat
- Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model October 1, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00624K, PaperMadhu Shree Poddar, Yu-De Chu, Gaurav Pendharkar, Cheng-Hsien Liu, Chau-Ting Yeh3D liver-on-a-chip reveals AHSG and CLEC3B to mediate cancer-associated fibroblast-induced resistance to TKIs in hepatoma cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Madhu Shree Poddar
- Microfluidic Hanging Droplet as a Programmable Platform for Mammalian Egg Vitrification October 1, 2024Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00428K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Haidong Feng, Georgios Katsikis, India Napier, Gong Du, Josh Lim, Joseph Doyle, Scott R. Manalis, Linda G GriffithEgg (oocyte) vitrification is the dominant method for preserving fertility for women of reproductive age. However, the […]Haidong Feng
- Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA September 30, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00628C, PaperJijo Easo George, Rajib Basak, Indresh Yadav, Chuan Jie Tan, Jeroen A. van Kan, Frank Wien, Véronique Arluison, Johan R. C. van der MaarelUsing nanofluidics to probe protein mobility on DNA reveals how DNA base methylation impacts protein–DNA interactions.To cite this article before page numbers are assigned, use the […]Jijo Easo George
- A microfluidic system for the cultivation of cyanobacteria with precise light intensity and CO2 control: Enabling growth data acquisition at single-cell resolution. September 29, 2024Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00567H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lennart Witting, Johannes Seiffarth, Birgit Stute, Tim Schulze, Jan Matthis Hofer, Katharina Nöh, Marion Eisenhut, Andreas Weber, Eric von Lieres, Dietrich KohlheyerQuantification of cell growth is central to any study of photoautotrophic microorganisms. However, […]Lennart Witting
- Surface modification of paper-based microfluidic devices via initiated chemical vapor deposition September 29, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00414K, Tutorial ReviewStacey Bacheller, Malancha GuptaPaper-based microfluidic devices offer a low-cost platform for biological and environmental detection. This tutorial review shows that initiated chemical vapor deposition can be used to modify these devices with functional polymers.To cite this article before page numbers are assigned, use the DOI form of citation […]Stacey Bacheller
- Microfluidic antisolvent crystallization for chiral symmetry breaking September 29, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00658E, PaperJiye Jang, Gerard Coquerel, Tae Seok Seo, Woo-Sik Kim, Bum Jun ParkMicrofluidic antisolvent crystallization was used to study the effect of solution volume on chiral symmetry breaking (CSB) in NaClO3 crystals. 100% CSB occurs below a critical emulsion volume due to rapid molecule depletion and suppressed nucleation.To cite this […]Jiye Jang
- High-throughput selection of sperm with improved DNA integrity and rapidly progressive motility using a butterfly-shaped chip compared to the swim-up method September 23, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00506F, PaperAli Sharafatdoust Asl, Mohammad Zabetian Targhi, Soroush Zeaei, Iman Halvaei, Reza NosratiThe BSC is developed to isolate 25 500 rapidly progressive sperm with improved DNA integrity in 20 minutes by incorporating a dual selection mechanism for ART.To cite this article before page numbers are assigned, use the DOI form of […]Ali Sharafatdoust Asl
- Inertial co-focusing of heterogeneous particles in hybrid microfluidic channels with constantly variable cross-sections September 23, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00479E, PaperTianwei Zhao, Peng Zeng, Yuanting Zhang, Jinxia Li, Hui Sun, Imrich Gablech, Honglong Chang, Xichen Yuan, Pavel Neužil, Jianguo FengInertial focusing chips based on hybrid microfluidic channels were presented for high-efficiency heterogeneous particle co-focusing, offering significant applications in microfluidic flow cytometry and single-cell analysis.To cite this article before page […]Tianwei Zhao
- 3D printing of monolithic gravity-assisted step-emulsification device for scalable production of high viscosity emulsion droplets September 22, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00650J, PaperYoon-Ho Hwang, Je Hyun Lee, Taewoong Um, Hyomin LeeA monolithic 3D-printed step-emulsification device is fabricated for scalable and robust production of high viscosity droplets.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Yoon-Ho Hwang
- Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion September 19, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00664J, PaperMd Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman, Christopher J. EasleyDroplet-based microfluidic sampling of adipose tissue reveals unique information on lipolytic dynamics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Md Moniruzzaman
- Artificial intelligence performance in testing microfluidics for point-of-care September 19, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00671B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mert Tunca Doganay, Purbali Chakraborty, Sri Moukthika Bommakanti, Soujanya Jammalamadaka, Dheerendranath Battalapalli, Anant Madabhushi, Mohamed S. DrazAI is revolutionizing medicine by enhancing diagnostics and patient care. Our study showed ML and DL AI models […]Mert Tunca Doganay
- Label-free single-cell antimicrobial susceptibility testing in droplets with concentration gradient generation September 19, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00629A, PaperJae Seong Kim, Jingyeong Kim, Jae-Seok Kim, Wooseong Kim, Chang-Soo LeeThis study presents a droplet-based microfluidic platform for rapid single-cell AST without the use of any fluorescent molecules or genetically modified bacteria expressing fluorescent proteins.To cite this article before page numbers are assigned, use the DOI form of citation […]Jae Seong Kim
- Vibration mixing for enhanced paper-based recombinase polymerase amplification September 19, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00592A, PaperKelli N. Shimazu, Andrew T. Bender, Per G. Reinhall, Jonathan D. PosnerIsothermal nucleic acid amplification tests are a vital tool for point-of-care diagnostics. In this work, we significantly improve paper-based recombinase polymerase amplification of HIV-1 DNA and RNA by employing a vibration-based mixing platform.To cite this article before page […]Kelli N. Shimazu
- Label-free high-throughput impedance-activated cell sorting September 19, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00487F, PaperKui Zhang, Ziyang Xia, Yiming Wang, Lisheng Zheng, Baoqing Li, Jiaru ChuA label-free high-throughput impedance-activated cell sorting platform can sort cells at a throughput of 1000 events per s.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Kui Zhang
- Improved Teflon lift-off for droplet microarray generation and single-cell separation on digital microfluidic chips September 17, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00630E, PaperChuanjie Shen, Zhaoduo Tong, Xin Xu, Hongju MaoHigh-throughput automated generation of droplet microarrays based on digital microfluidic chips for single-cell isolation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryChuanjie Shen
- Utilization of microdroplets as optical lenses for surface-enhanced Raman spectroscopy (SERS) enhancement on localized silver nanoparticle-decorated porous silicon substrates September 17, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00550C, PaperChia-Wen Tsao, Zi-Yi YangWe demonstrate the use of a microdroplet as an optical lens positioned on a localized silver nanoparticle-decorated porous silicon (LocAg-PS) surface for enhanced surface-enhanced Raman spectroscopy (SERS) analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Chia-Wen Tsao
- A three-dimensional vessel-on-chip model to study Puumala orthohantavirus pathogenesis September 17, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00543K, PaperDanny Noack, Anouk van Haperen, Mirjam C. G. N. van den Hout, Eleanor M. Marshall, Rosanne W. Koutstaal, Vincent van Duinen, Lisa Bauer, Anton Jan van Zonneveld, Wilfred F. J. van IJcken, Marion P. G. Koopmans, Barry RockxWe studied PUUV infection in high-throughput 3D endothelial vessels-on-chip, that more closely […]Danny Noack
- Integrated microfluidic multiple electrode aggregometry for point-of-care platelet function analysis September 17, 2024Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00469H, PaperX. Zhao, V. R. Gopal, F. Lozano-Juan, K. Kolandaivelu, A. Sarkar, D. Wu, J. Su, Q. Cheng, R. Pang, L.-S. WuWe present a flow-based microfluidic sensor suited for POC applications with embedded microelectrode array to perform platelet aggregometry directly from whole blood by sweeping across multiple frequencies.To cite this […]X. Zhao
- Towards Real-Time Myocardial Infarction Diagnosis: A Convergence of Machine Learning and Ion-Exchange Membrane Technologies Leveraging miRNA Signatures October 3, 2024
