RSC – Lab Chip latest articles- A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh April 24, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00182C, PaperShogo Iwai, Daisuke Sasaki, Tetsutaro Kikuchi, Katsuhisa Matsuura, Kenjiro Fukuda, Sunghoon Lee, Tatsuya Shimizu, Takao Someya, Shinjiro UmezuMechanical stretch is a vital factor influencing the structural and functional properties of cardiac tissue, including its contractile force. While various platforms using elastic substrates have been developed to measure...The content of […]Shogo Iwai
- A combinatorial screening platform for in situ gene delivery to adherent cells via digital microfluidics and flexible electrodes April 23, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00124F, PaperYi Weng, Xiangyu Ren, Fuqiang Guo, Weichao Wu, Bin Wang, Chaobo LiThe PDES platform solves the bottlenecks of traditional electroporation methods: manual operation, high reagent use, and low throughput. The micro-level automated reaction system allows multidimensional orthogonal screening and fast optimization of electrical parameters and biological components.To cite this […]Yi Weng
- Capillary microsampling enables on-site collection and storage of plant sap April 23, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00201C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ellinor Hedberg, Jaime Sebastián-Azcona, Federico Ribet, Virginia Hernandez-Santana, Göran Stemme, Antonio Diaz Espejo, Niclas RoxhedPlant sap analysis typically relies on destructive sampling and immediate freezing, limiting field deployment and longitudinal studies. We introduce a […]Ellinor Hedberg
- Rapid fabrication of solvent-compatible NOA 81 microfluidic devices for double-emulsion microfluidics April 23, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00045B, PaperRyan Garry, Vladimir Sincari, Wentao Xu, Anurag Dhande, David A. WeitzRapid, low-cost organic solvent-compatible microfluidic device with localized surface modification for w/o/w emulsion templating of capsules and giant unilamellar vesicles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Ryan Garry
- Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles April 21, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00098C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Wenyang Jing, Heewon Noh, Timothy J. C. Tan, Nicholas C. Wu, Hee-Sun HanDecoding dewetting dynamics in double emulsions establishes predictive rules for robust, tunable GUV assembly. This physics-based framework provides systematic guidance to optimize […]Wenyang Jing
- Estimating single-cell elastic modulus in a serial microfluidic cytometer from time-of-flight and fluorescence signals analysis April 20, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00930H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Graylen R. Chickering, Leroy L. Jia, Matthew DiSalvo, Megan A. Catterton, Paul N. Patrone, Eric M. Darling, Gregory A. CookseyParticles can migrate in flow based on size and deformability, resulting in measurable time-of-flight differences. […]Graylen R. Chickering
- Independent parallel production of tunable blood clot analogues in hourglass-profiled circular PDMS fluidic channels April 20, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00190D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chun-Hsin Hsu, To-Wen Chen, Wei-Jen Soong, Chihchen ChenRapid removal of occluding blood clots, whether by intravenous thrombolysis or endovascular thrombectomy, can be life-saving. Yet recanalization is not always successful, and the determinants remain incompletely […]Chun-Hsin Hsu
- Dynamic Gap Structure for High-Throughput Measurement of Cellular Mechanical Properties April 20, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01162K, Paperdoudou ma, Nobutoshi Ota, Masaya Taniguchi, Yu-Hau Ye, Kazunori Okano, Yuri Ito, Naomi Tanga, Yoichiroh Hosokawa, Kazuya Sakai, Yo Tanaka, Koki Yamamoto, Yaxiaer YalikunPrecise quantification of cellular mechanical properties (Young's modulus) is essential for understanding cellular physiology, disease progression, and therapeutic responses. In contrast to existing deformability cytometry approaches […]doudou ma
- Centrifuge-free separation of plasma from milliliters of whole blood for point-of-care diagnostics April 19, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00135A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Christia M. Victoriano, Bianca Arraiza Carlo, Abigail G. Ayers, Kelia A. Human, Samuel K. SiaPlasmaLIFT enables automated plasma separation from milliliters of whole blood by integrating immunomagnetic red blood cell depletion with dual-membrane filtration.To […]Christia M. Victoriano
- A microfluidic skin-on-a-chip enabling in situ construction of full-thickness human skin for modeling inflammatory diseases April 16, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00189K, PaperLinwei Sang, Ajing Liu, Junjie Zhu, Qian Yang, Zheng Liu, Shu-Wei Chen, Jinyi WangThis study presents a detachable microfluidic skin-on-a-chip. Using epidermal–dermal co-culture under dynamic perfusion, the chip enables on-chip construction of inflammatory phenotype and drug evaluation.To cite this article before page numbers are assigned, use the DOI form […]Linwei Sang
- Stretchable Mesoporous Electrodes as a Versatile Platform for Minimally Invasive Surgical Devices April 16, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00110F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael Abraham Listyawan, Chi Cong Nguyen, Tran Bach Dang, Nhat Minh Doan, Quang Anh Nguyen, Yulin Qiu, Eva Tomaskovic-Crook, Mostafa Kamal Masud, Yusuke Yamauchi, Jeremy Micah Crook, Mohit Naresh Shivdasani, Thanh Nho Do, Hoang-Phuong […]Michael Abraham Listyawan
- Porous microneedle-based electrochemical aptamer biosensor for collection and quantitative analysis of dry eye disease biomarkers April 15, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00230G, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eira Beryle Ko, Tianli Hu, Ya Zhang, Xueyan Wang, Yu Song, Chenjie XuDry eye disease (DED) is a prevalent ocular disorder driven by tear film instability and inflammation. The quantitative measurement of molecular biomarkers […]Eira Beryle Ko
- Selective on-chip DNA synthesis using electric field-assisted PCR April 15, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01200G, PaperDoyeon Lim, Youngjun SongAn electric field-assisted PCR platform enables selective on-chip DNA synthesis with precise spatial control using microelectrode arrays. This scalable approach achieves high-efficiency enzymatic synthesis for DNA data storage and diagnostics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Doyeon Lim
- LEGO®-inspired electrically-actuated microfluidics for on-chip protein crystallization and in situ X-ray crystallography April 14, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00021E, PaperSarthak Saha, Logan Chen, Gabrielle R. Budziszewski, Sara Koprek, Kaleb Seifert, Aina Cohen, Silvia Russi, Sarah E. J. Bowman, Sarah L. PerryLow-voltage valve actuation to facilitate protein crystallization and in situ X-ray structure determination.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Sarthak Saha
- Ultra-high throughput droplet microfluidics for cultivation and functional screening of environmental microbial strains and consortia. April 14, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01115A, Tutorial ReviewLuca Potenza, Jozef Krzak, Maciej Stefan Andrzejewski, Adam Pyzik, Tomasz KaminskiScreening of microbial diversity is critical for discovering novel strains with enhanced biocatalytic capabilities. Traditional cultivation techniques often miss rare or slow-growing microorganisms, limiting our understanding of environmental microbiomes and...The content of this RSS Feed (c) The Royal […]Luca Potenza
- Human hair regeneration using organoids and hair-on-chip technologies April 14, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00095A, PerspectiveImaan A. Ahmed, Abbas ShafieeCurrently, no therapies exist for regenerating appendage bearing skin. New developments in biofabrication, stem cell research, organoids, and other technologies hold promise for skin regeneration with optimal cosmetic and functional outcomes.To cite this article before page numbers are assigned, use the DOI form of citation […]Imaan A. Ahmed
- Microfluidic well plates integrated with passive nematode culture chambers for multiplexed chemical toxicity assays in C. elegans April 13, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01165E, PaperBushra Rahman, Purushottam Soni, Atiyya P. Saroyia, William Schenkenfelder, Siva A. VanapalliPNC well plates enable low-intervention, multiplexable C. elegans assays with translational potential for predictive toxicology.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Bushra Rahman
- Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery April 12, 2026Lab Chip, 2026, 26,2415-2438DOI: 10.1039/D5LC01131K, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Doriane Le Manach, Vincent Senez, Matthias NeesCAF-driven matrix remodeling creates quantifiable transport barriers to drug delivery. Tumor-on-chip platforms enable transport phenotyping to decode and target these stromal barriers.The content of this RSS Feed (c) […]Doriane Le Manach
- Region-specific proteomic profiling of brain interstitial fluid via a micro-invasive sampling platform April 12, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00038J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qun Cao, Hannah D. Jackson, Aidan J. Duncan, Yufei Cui, Haley O. Higginbotham, Stella Lesnik, Yunseo Jo, Jiaquan Yu, Forest M. White, Michael J. CimaThis study presents a localized, membrane-free method for sampling brain […]Qun Cao
- Microparticle-enabled single cell multiparameter electronic immunophenotyping for selective electroporation April 11, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00180G, PaperMadeline Hoyle, Josiah Rudge, Yuvraj Rallipalli, Aniruddh SarkarDetection of multifrequency impedance signatures of microparticle labeled single cells in a 3D printed microfluidic channel enables real time selective electroporation of cell subpopulations for cell engineering.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Madeline Hoyle
- A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh April 24, 2026
