RSC – Org. Biomol. Chem. latest articles- Preparation of poly-N-(methyl)aminooxy serine polypeptides by NCA ring-opening polymerization for modification with reducing oligosaccharides September 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00985E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Palmieri, Marlinde D. Waardenburg, Justyna M. Dobruchowska, Elena Roditis, Tina Vermonden, Geert-Jan BoonsN-carboxyanhydride (NCA) ring-opening polymerization offers an attractive approach for the construction of polypeptides. Here, we report the synthesis of a […]Francesco Palmieri
- Transition Metal-Free Stereospecific Di-Chalcogenations of Substituted Acetylenes September 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01108F, PaperYen-Ting Chang, Indrajit Karmakar, Rekha Bai, Chin-Fa LeeWe report a one-pot, transition metal-free, stereospecific di-chalcogenation reaction for the synthesis of a diverse range of substituted Z-di-organochalcogenides. This method employs Cs2CO3 as a non-toxic basic catalyst in dimethyl...The content of this RSS Feed (c) The Royal Society of ChemistryYen-Ting Chang
- Perspectives on metal-catalysed syntheses of carbolines (α/β/γ/δ): recent advances September 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01250C, Review ArticleSarat Chatterjee, Chinmay ChowdhuryIn this review, we provide a brief yet comprehensive account of the metal-catalysed syntheses of four isomeric carbolines (α/β/γ/δ) along with the mechanistic pathways involved in the aforesaid strategies.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Sarat Chatterjee
- UV-mediated anomeric activation September 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01184A, PaperNiklas Henrik Fischer, Alicja Klaudia Bałuta, Maciej Tadeusz Szpak, Peter Waaben Thulstrup, Christian Marcus PedersenNonaromatic photoinitiation of trichloroacetimidates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryNiklas Henrik Fischer
- Rhodium-catalyzed ortho-C–H alkylation of benzaldehydes with maleimides free of transient directing groups September 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01336D, CommunicationJing-Wen Jia, Wen-Ting Wei, Xiao-Zuan Chen, Xian-Ying ShiA rhodium-catalyzed conjugate addition of C–H bonds to maleimides directed by a weakly coordinating aldehyde group was developed as a facile protocol to synthesize ortho-alkylated benzaldehydes in moderate to excellent yields (up to 90% yield).To cite this article before page numbers […]Jing-Wen Jia
- Visible-light-driven domino reactions toward nitrogen-containing heterocycles September 11, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01274K, Review ArticleYang Li, Dong Xia, Wen-Chao YangThis review highlights recent advances in visible-light-induced domino reactions for the synthesis of nitrogen-containing heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYang Li
- Efficient synthesis of tetrahydroquinolines via selective reduction of quinolines with copper salts and silanes September 11, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01085C, CommunicationYulong Zhang, Xinyu Luo, Yushuang ChenWe developed a cost-effective catalytic system using cheap copper salts and silanes to achieve efficient partial hydrogenation of quinolines under mild conditions, yielding diverse 1,2,3,4-tetrahydroquinolines with up to 98% efficiency.To cite this article before page numbers are assigned, use the DOI form of […]Yulong Zhang
- Tunable regiodivergent C–H alkenylation of 2-arylthiazoles via catalyst control September 10, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01310K, PaperGuibin Wan, Cheng Wang, Pengfei Zhou, Yi Tang, Dingyi Xu, Taoyuan Liang, Zongwu Wei, Zhuan ZhangWe have developed a novel and efficient Pd(II)- and Ru(II)-catalyzed switchable C–H alkenylation of 2-arylthiazoles with alkenes, achieving high levels of regio- and stereoselectivity.To cite this article before page numbers are assigned, use […]Guibin Wan
- Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application in drug modification September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01389E, CommunicationSheng Yu, Yangjian Cheng, Changduo Pan, Jin-Tao YuA photocatalytic radical cascade cyclization of N-acryloylhydrazides with α-bromoketones, α-bromo difluoroacetamides and 2-bromoacetonitrile was developed for the construction of functionalized pyrazolones.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Sheng Yu
- Eco-efficient C–H alkynylation of indoles via mechanochemical ruthenium catalysis September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01198A, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rajaram Maayuri, Vikash Kumar, Sourav Maiti, Parthasarathy GandeepanMechanochemical ruthenium(II)-catalyzed C2-alkynylation of indoles offers a sustainable alternative to solution-phase methods with improved green metrics and broad synthetic scope.To cite this article before page numbers […]Rajaram Maayuri
- Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01223F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Katarzyna Jastrzębska, Agata Szymańska, Tomasz Pawlak, Rafał DolotWe demonstrate the oxathiaphospholane-based synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs with confirmed stereochemistry and enzymatic stability, highlighting their potential for therapeutic applications.To cite this […]Katarzyna Jastrzębska
- Advances in the direct transformations of propargylic alcohols and sulphur-containing reagents September 9, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01220A, Review ArticleJiayi Chao, Rumeng Yang, Jiarui Huang, Xi Chen, Xian-Rong Song, Qiang XiaoSulphur-containing compounds are regarded as an important class of organic compounds that are widely applied in pharmaceuticals, agriculture, material sciences, natural products, and organic synthesis. Consequently, the development of synthetic...The content of this RSS Feed (c) […]Jiayi Chao
- Annulative coupling of dicoumarols and β-ketosulfoxonium ylides: access to dihydrofuran-fused coumarins September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01305D, PaperRahul Kumar Saini, Satyendra Kumar PandeyA reagent- and catalyst-free cascade annulation of dicoumarols with β-ketosulfoxonium ylides has been developed, offering a scalable and versatile route to bioactive dihydrofuran-fused coumarins through concurrent C–C and C–O bond formation.To cite this article before page numbers are assigned, use the DOI form […]Rahul Kumar Saini
- Anthracene-isatoic anhydride hybrids for bioconjugation: chromophores with nucleophile dependent response September 9, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01187F, PaperChloe D. Fordyce, Callum J. Robinson, Gabriel E. RudebuschAnthracene-based bioconjugate reagents transform into unique donor–acceptor chromophores when reacted with amines, alcohols or thiols. An 11-residue peptide is selectively labeled at the lysine side chain.To cite this article before page numbers are assigned, use the DOI form of citation […]Chloe D. Fordyce
- Stereoselective synthesis of 3,3′-spirooxindoles with higher order heterocycles September 8, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01278C, Review ArticleR. T. Starthring, Biplob Borah, L. Raju ChowhanIn this article, the stereoselective construction of spirooxindoles featuring larger ring size heterocycles are disclosed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]R. T. Starthring
- A Synthesis of 1β-Hydroxytestosterone, a Metabolite of Xenobiotic Human Cytochrome P450 Enzymes, Beginning with a Borylation of Boldione September 8, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01218J, PaperAnna I. Elizondo, Kevin D. McCarty, Hadi Arman, F. Peter Guengerich, Francis YoshimotoXenobiotic cytochrome P450 enzymes have been shown to hydroxylate testosterone at various positions in the steroid backbone, including C1 to produce 1β-hydroxytestosterone. Despite the potential application to study the biochemistry...The content of this RSS Feed (c) […]Anna I. Elizondo
- DBU-catalysed cascade nucleophilic addition/cyclization to access 7-nitro (ester) imidazo[1,2-a] pyridin-8-amines September 8, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01228G, PaperDevendra Nagineni, Abburi Naga Pranathi, Prakash Suman Behera, Manasa Konderpu, Balasubramanian Sridhar, Srinivas KantevariA DBU-catalysed, solvent-free cascade approach is presented for the synthesis of C-7-nitro/ester- and C-8-amine-substituted imidazo[1,2-a]pyridines, from cyanoalkyne precursors and CH-acid via the formation of two new C–C bonds.To cite this article before page numbers are […]Devendra Nagineni
- Electrochemical N-sulfonylation of in situ generated indole-based hydrazones and antimicrobial evaluation September 8, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01107H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Parmjeet Kaur, Anuj Kumar, Tashi Palmo, Kuljit Singh, Vikas TyagiHerein, we report a novel metal-free electrochemical strategy for regioselective N-sulfonylation of in situ generated indole-based hydrazones using readily available sodium sulfinates.To cite this […]Parmjeet Kaur
- The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones September 7, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01290B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Bimod Thapa, Farideh Javid, Cameron Lawson, Mark Soesanto, Karl HemmingAminocyclopropenones undergo a stereospecific and regiospecific catalyst-free, thermal ring-opening reaction with alcohols to yield β-enamino esters (also known as vinylogous carbamates or aminoacrylates).To cite […]Bimod Thapa
- Recent advances in photoinduced amidyl radical-mediated remote C(sp3)–H activation via 1,5-hydrogen atom transfer September 7, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01197C, Review ArticleMin Liao, Yuanyuan Li, Meiling Ye, Chunjuan LiuThis review highlights the recent advances in the functionalization of remote inert C(sp3)–H bonds triggered by nitrogen-centered radicals (NCRs) via photoinduced 1,5-hydrogen atom transfer processes.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Min Liao
- Preparation of poly-N-(methyl)aminooxy serine polypeptides by NCA ring-opening polymerization for modification with reducing oligosaccharides September 16, 2025
