RSC – Org. Biomol. Chem. latest articles- Green Synthesis of α-Aminophosphonates: From Hydrogen-Bonded Janus Dimers to Pharmaceutical Potential November 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01712B, PaperRawda Kholany, Alaa A Mardini, Ksenia Shakirova, Daut Islamov, Alexander Gerasimov, Alexander Klimovitskii, Alena A. Vavilova, Olga Mostovaya, Asiya Gazizova, Ivan StoikovA family of α-aminophosphonates, dimethyl (A), dipropyl (B), and diisopropyl (C), was synthesized through a green, catalyst-free Kabachnik–Fields reaction and characterized using FT-IR, NMR, UV–Vis, single-crystal X-ray […]Rawda Kholany
- Nickel-Catalyzed Isocyanide Insertion Reaction with Aromatic Amines: Direct Access to Open-Chain Guanidines November 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01509J, CommunicationZhe Zheng, Hongqiang Ma, Hongwei Jin, Bingwei Zhou, Yuanyuan HuHerein, a nickel-catalyzed isocyanide insertion reaction with aromatic amines under open-air conditions is disclosed. A number of open-chain guanidines are successfully synthesized in moderate to good yields and the structure...The content of this RSS Feed (c) The Royal Society […]Zhe Zheng
- A telescoped diastereoselective synthesis of phthalimido-substituted spiro-oxazoline oxindoles via aziridine expansion strategy November 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01645B, PaperAnna A Nikolaeva, Ilya P. Filippov, Oleg E Polekh, Alena S. Pankova, Nikolai V. RostovskiiA diastereoselective efficient synthesis of 5'H-spiro[indoline-3,2'-oxazol]-2-ones bearing the pharmacophore phthalimide fragment was developed. The approach is based on the thermal ring opening of spiro-aroyl-N-phthalimidoaziridine oxindoles readily available by aminoaziridination of...The content of this RSS […]Anna A Nikolaeva
- Carboxylate migration from ethyl cyanoformate to methylene: rapid access toward pyrrolo[1,2-a]pyrazines November 28, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01529D, PaperNithiniyal Patamajhi, Sandya Tambi Dorai, Surbhi Mahender Saini, Bikash Kumar Behera, Arbaz Khan, Sandeep ChandrashekharappaA novel synthetic strategy to construct pyrrolo[1,2-a]pyrazines has been developed utilizing a 1,5-dicarbonyl precursor through C–C bond formation between methylene group and ethyl cyanoformate under basic conditions.To cite this article before page numbers are […]Nithiniyal Patamajhi
- Selective synthesis of 4,5-dihydropyrenes by a Brønsted acid-catalyzed cyclization cascade of biphenyl-embedded enynes November 28, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01626F, CommunicationJaime Tostado, Lucía Sánchez-Jiménez, Manuel A. Fernández-RodríguezA Brønsted acid-catalyzed cascade provides a sustainable alternative to metal-catalyzed routes, delivering 4,5-dihydropyrenes relevant to bioactive compounds and materials.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]Jaime Tostado
- Ruthenium-Catalyzed Late-Stage C–H Alkenylation of N-arylpyridazino[4,5-b] quinolin-1(2H)-ones November 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01511A, PaperChinnagounder Kameshwaran, Fazlur-Rahman Nawaz KhanA ruthenium-catalyzed one-pot sequential cascade has been developed for the synthesis of functionalized pyridazino[4,5-b]quinolin-1(2H)-ones. The sequence comprises Ru/Cu-catalyzed C(sp3)–H oxidation, cyclization with hydrazine hydrate, Chan–Lam N–H arylation, and Ru/Cu-mediated ortho-selective...The content of this RSS Feed (c) The Royal Society of ChemistryChinnagounder Kameshwaran
- Theoretical Exploration of the Diene-Transmissive Hetero-Diels-Alder Strategy Toward Boron-Functionalized Octahydroquinolines November 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01638J, PaperAmine Rafik, Abdeljabbar Jaddi, Khalid Abbiche, Mohammed Salah, Miguel Carvajal, khadija MarakchiA diene-transmissive hetero-Diels–Alder strategy, grounded in previous experimental works and employing boronated dienophiles, is proposed for the synthesis of boron-bearing octahydroquinolines. To assess its feasibility, three representative reactions were investigated,...The content of this RSS Feed (c) The […]Amine Rafik
- Pd-Catalyzed Efficient Synthesis of Benzo[4,5]imidazo[1,2-a]indoles with Diaziridinone November 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01335F, CommunicationJianjun Wang, Xiao Zhang, Shiwei Zhang, Wei Liu, Yian ShiThis work describes an efficient Pd-catalyzed synthesis of benzo[4,5]imidazo[1,2-a]indoles from readily available 1-(2-iodophenyl)-1H-indoles and di-t-butyldiaziridinone. A vareity of benzo[4,5]imidazo[1,2-a]indoles can be obtained in up to 96% yield. The reaction likely...The content of this RSS Feed (c) The Royal Society […]Jianjun Wang
- Recent Advances in Applications of Metal Hydride Hydrogen Atom Transfer for Natural Product Synthesis November 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01671A, Review ArticleYogesh G Shelke, Surasmita DhalMetal hydride hydrogen atom transfer (MHAT) has emerged as a powerful strategy for alkene hydrofunctionalization, offering high levels of chemo-, regio-, and stereocontrol. In recent years, this reaction has provided...The content of this RSS Feed (c) The Royal Society of ChemistryYogesh G Shelke
- Stereoselective synthesis of functionalized perhydropyrrolo[1,2-b]isoxazoles based on (3+2)-annulation of donor-acceptor cyclopropanes and isoxazolines November 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01604E, PaperKonstantin V. Potapov, Maxim A. Novikov, Yaroslav V. Kozmenko, Pavel N. Solyev, Alexander D Volodin, Alexander Korlyukov, Roman A Novikov, Yury TomilovA Stereoselective route to substituted pyrrolidine core via Lewis acid catalyzed (3+2)-annulation of donor-acceptor cyclopropanes (DAC) to isoxazolines was developed. Exclusive cis-2,5-stereoselectivity was governed by kinetically-controlled conditions […]Konstantin V. Potapov
- Correction: Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs November 27, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90153G, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar AhmedTo cite this article before page numbers are assigned, use the DOI form […]Sidra Siddique
- Correction: C–H bond cyanation: electrochemical synthesis of phenylbenzimidoyl cyanide derivatives November 27, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90154E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Najoua Sbei, Seyfeddine Rahali, Nisar AhmedTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryNajoua Sbei
- Elucidating the mechanism, origin of regioselectivity and substrate scope of structurally diverse 1,2,4-triazoles synthesis via rare type of diazo compounds reactivity November 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01650A, PaperRoman Kuznetsov, Grigory Kantin, Alexander Sapegin, Mikhail Sergeevich Novikov, Dmitry Dar'inThe 1,2,4-triazole scaffold plays a significant role in drug development, and efficient methods for synthesizing its derivatives are in high demand. In this work, we propose a convenient approach to...The content of this RSS Feed (c) The Royal […]Roman Kuznetsov
- Fe(NO₃)₃•9H₂O-Mediated Visible-Light Photocatalysis for the Nitration of Cyclobutanols: Access to Functionalized Nitrocyclobutenes November 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01627D, PaperDongfang Jiang, Can Yang, Xinying Man, Xin Li, Haifei Wang, Zhenjie Qi, Yunlin SongA straightforward method for the synthesis of nitrocyclobutenes derivatives from cyclobutanols with Fe(NO3)3•9H2O has been developed via visible-light photocatalytic radical addition reaction. The reaction utilizes Fe(NO3)3•9H2O as nitro source and...The content of this RSS Feed […]Dongfang Jiang
- Nitrones as directing groups in transition metal-catalysed C-H activation November 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01568E, Review ArticleBarbara Stańska, Anjali Dahyia, Rafał LoskaDuring the last about 15 years, nitrones have emerged as versatile directing groups for transition metal-catalysed C-H activation reactions. Apart from simple functionalization of the aryl ring attached to the...The content of this RSS Feed (c) The Royal Society of ChemistryBarbara Stańska
- Electrochemically-Generated Ferricyanide Enables Thiol-ene Capture of Protein-Protein Binding November 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01728A, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Joanna Francelle McGouran, André Campaniҫo, Denise Sommer, Chris Batchelor-McAuleyDue to its efficiency, selectivity and biocompatability, the thiol-ene coupling has demonstrated its potential for protein labelling. Here, we report the electrochemical thiol-ene activation to […]Joanna Francelle McGouran
- FLARE: A label-free FLuorescence Assisted method for RNA Engineering of three-way junctions November 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01756D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.A Murali Krishna, Nida Fathima, Jothi Basu, Ashwani SharmaRNA three-way junction (3WJ) motif is an important structural element found in the majority of RNAs, and the thermal stability of these structural motifs is […]A Murali Krishna
- Photoredox/NHC-catalyzed remote alkylation of γ-functionalized enals with N-substituted pyridinium salts November 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01714A, CommunicationYuan-Yuan Xu, Chang-Chun Liu, Zhi-Hao Shen, Ben-Cai Dai, Junan Ma, Yang ZhouWe report a dual photoredox/NHC-catalyzed method for the regioselective remote alkylation of γ-functionalized enals. Using abundant Katritzky pyridinium salts as alkyl radical precursors and γ-functionalized enals to form trienolate intermediates,...The content of this RSS Feed (c) The […]Yuan-Yuan Xu
- A pathway to synthesize 2-methylbenzothiazole derivatives via a hydrogen sulfide promoted tandem reaction of calcium carbide and 2-iodoaniline November 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01633A, PaperYunzhe Du, Shuyi Li, Siliu Cheng, Ligang Yan, Ruijun Xie, Limin Han, Ning ZhuIn this study, a new method for synthesizing 2-methylbenzothiazole derivatives was developed through a multi-component tandem reaction of 2-iodoaniline/1-iodo-2-nitrobenzene, CaC2, and H2S.To cite this article before page numbers are assigned, use the DOI form of […]Yunzhe Du
- Dicarboxylate and dicarboxylic acid appended supramolecular self-associating amphiphiles as antimicrobial agents against high priority bacterial pathogens November 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01615K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lisa J. White, Bree Streather, J. Mark Sutton, Jennifer Rankin, Jennifer Baker, Charlotte Bennett, Hollie B. Wilson, Charlotte K. Hind, Jennifer R. HiscockChiral SSAs show antimicrobial activity, targeting key pathogens, with potential for […]Lisa J. White
- Green Synthesis of α-Aminophosphonates: From Hydrogen-Bonded Janus Dimers to Pharmaceutical Potential November 29, 2025
