RSC – Org. Biomol. Chem. latest articles- H-bonding, not remote participation, explains the influence of remote substituents on stereoselectivity in α-galactosylations November 5, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01495F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kate E. Donaghy, Dionissia A. Pepe, Joseph J. Ruddy, Eoghan M. McGarrigleNon-classical H-bonding of a 4-O-benzoate ortho-hydrogen with the triflate leaving group leads to highly α-selective galactosylation; thus a para-nitrobenzoate outperforms alternatives and […]Kate E. Donaghy
- Hypervalent iodine-mediated highly mono- and di-selective etherification of 8-aminoquinolines on the C5 and C6 positions† November 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01378J, CommunicationHongen Qu, Pei Liang, Shi Qiu, Shangqing Xiao, Panpan Huang, Hengshan Wang, Zhonggao Zhou, Liangxian LiuA mild, metal-free and highly regioselective approach for etherification of 8-aminoquinoline scaffolds on their C5 and C6 positions has been developed with hypervalent iodine compounds. The transformation proceeds by the...The content of this […]Hongen Qu
- Electrochemical Synthesis of Hydroxyalkylated Quinoxalines via C-H Functionalization November 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01521A, PaperShuaishuai Dai, Dongping Xu, Lizhen Jin, Yuan-Chao Zha, Wu ZhangAn efficient electrochemical C-H hydroxyalkylation of quinoxalines with aldehydes and ketones has been developed in an undivided cell. A variety of aliphatic and aromatic aldehydes as well as ketones have...The content of this RSS Feed (c) The Royal Society […]Shuaishuai Dai
- Visible-Light-Induced Radical Trifluoromethylation/Cyclization of Alkynes: Synthesis of CF3-Containing Dioxodibenzothiazepines November 5, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01520K, CommunicationXiaoyu Chen, Yang Geng, Pan Liu, Zhiyong Wu, Dapeng Zou, Yangjie Wu, Yusheng WuA simple and metal-free photoinduced radical trifluoromethylation/cyclization reaction of alkynes with readily preparable and air-stable trifluoromethyl thianthrenium triflate (TT-CF3 + OTf -) as the trifluoromethyl source has been developed. This...The content of this RSS Feed […]Xiaoyu Chen
- CuI/TEMPO Mediated Aerobic Oxidative sp3 C-H Functionalization Leading to Pyrrol-2-one Derivatives November 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01297J, CommunicationAritra Mondal, Sunanda Mandal, Saikat Khamarui, Souvik Mondal, Bholanath Maity, Tanmoy Dutta, Ayan Hazra, Paramita Das, Suman Ray5-Hydroxy-1H-pyrrol-2-ones represent a very important class of compounds; however, their syntheses rely on the precursors that are quite exotic and commercially unavailable or multistep operations. Though cascade reaction is an...The content […]Aritra Mondal
- Beyond structure and activity: Targeting Class A Carbapenemase with Monocyclic and Bicyclic Boronic Acids to Counter Antimicrobial Resistance November 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01703C, CommunicationKunal Dhankhar, Mousumi Hazra, Adwaita S. Nair, Alaa Eddin Alhmeidi Alkhatib, Narayan Chandra Mishra, Saugata HazraBicyclic boronic acids inhibit SME-1 carbapenemase via a unique π–π stacking with His105 and covalent interaction with Ser70. Ledaborbactam shows the strongest inhibition, with the lowest ki and enhanced structural...The content of this […]Kunal Dhankhar
- TBAI-catalyzed C-H bond activation to construct C(sp3)-O bond in water: the synthesis of indole-3-carboxylic-α-esters under metal-free conditions November 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01449B, CommunicationXinyuan Zhang, Yufang Sun, Yujie Qu, Shengxing Xie, Fuchun Yang, Chengyu Wang, Jiawen Du, Xiaofeng Zhu, Lingkai Kong, Neng-Fei WangAn environmentally friendly and green transition-metal-free TBAI-catalyzed C-O coupling reaction via C(sp3)-H activation was developed to construct indole-3-carboxylic-α-ester in water. This reaction exhibits a broad substrate scope and good […]Xinyuan Zhang
- Visible light photocatalytic reductive hydroalkylation and deuterium alkylation to access α-Silylated bicyclo[1.1.1]pentanes November 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01555C, CommunicationChanglong Zheng, Xin Liu, bin hu, ting Lin, Shi-Peng Luo, Chenguang LiuAs pharmacophores, both bicyclo[1.1.1]pentane(BCPs) sacaffold and silyl substituents have found widespread applications in drug discovery. However, systematic synthetic methods for α-silylated BCPs remain limited. Herein, we report a photocatalytic hydro/deutero-alkylation...The content of this RSS Feed (c) The […]Changlong Zheng
- FeCl3 Catalyzed Synthesis of Fluorene-C-9-linked Furan Hybrids from Biphenyl-linked Conjugated Ene-Yne-Ketones November 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01258A, PaperAsadujjaman Nur, Umasish Jana, Abhishek Kar, Kush Mandal, Rajkamal SahooIn this study, we present a novel and efficient synthetic strategy for the construction of fluorene-C-9-tethered furan hybrids in excellent yields, starting from biphenyl-linked conjugated ene-yne-ketones. The reaction proceeds under...The content of this RSS Feed (c) The Royal Society […]Asadujjaman Nur
- Copper-Catalyzed Cross-Coupling Reaction of Epoxides with Allyl Boron Ester November 4, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01598G, PaperXiao-Yu Lu, Jun-Long Zhang, Hao-Yu Dong, Tng-Ting Liu, Xin-Ru Hu, Jin-Tao Tao, Wen-Jing Li, Hui-Tao ZhouHerein, a copper-catalyzed ring-opening cross-coupling reaction of epoxides with allylboronates for the synthesis of γ-alkenyl alcohols is reported. This protocol demonstrates broad functional group compatibility, facilitating the production of secondary...The content of this […]Xiao-Yu Lu
- Tuning artificial oxidase catalysis by cavity modification November 4, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01574J, PaperMingzhe Ren, Mikael BolsEpimerisation of two stereocenters in an articial oxidase changes its kinetic parameters.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryMingzhe Ren
- Reactivity of an aza-dipyrrin and an aza-BODIPY motif bearing two 2-pyridyl units: an emissive NNN binding pocket November 3, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01628B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rosinah Liandrah Gapare, Roberto M. Diaz-Rodriguez, Victoria A. Williams, Mark Atwood, Michael J. Cotnam, James W. Hilborn, Erin R. Johnson, Katherine N. Robertson, Alison ThompsonPro-ligand to aza-BODIPY fluorophore provides turn-on metal sensing via […]Rosinah Liandrah Gapare
- Tandem, copper-catalyzed monodesilylation/CuAAC reactions of 1,4-bis(trimethylsilyl)-1,3-butadiyne and azides for preparation of 4-(TMS-ethynyl)-1,2,3-triazoles November 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01592H, CommunicationYibin Wang, Liyi Feng, Xinying Luo, Liuran Li, Luyong Wu, Yuxue ChenA tandem copper-catalyzed 1,4-bis(trimethylsilyl)-1,3-butadiyne (BTMSBD) monodesilylation/azide CuAAC has been developed for the efficienet syntheis of 1-substituted-4-(TMS-ethynyl)-1,2,3-triazoles. The one-pot, two-step process, which occurs in yields up to 73%, is peformed by...The content of this RSS Feed (c) The […]Yibin Wang
- Synthesis of chiral α-alkynyl-α-hydroxyamides by enantioselective alkynylation of α-keto amides November 1, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01546D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Elena Prieto, Celia Andres, Javier NietoThe α-hydroxyamide moiety is an important structural component in a wide variety of biologically active compounds as well as natural products. Herein, we describe a highly efficient and […]Elena Prieto
- Development and Applications of Heterogeneous Chiral Bifunctional Alkaloid-Thioureas as Recyclable Organocatalysts October 31, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01582K, PaperAinara Pellicer, Xabier del Corte, Nora Aramburu, Javier Vicario, Patrick Yves Toullec, Aitor MaestroThe development of heterogeneous chiral catalysts is a growing research field, as a recyclable alternative to their homogeneous counterparts. Aiming to identify a general and reliable methodology to access highly...The content of this RSS Feed […]Ainara Pellicer
- Regioselective copper-catalyzed dearomative alkynylation of N-alkyl nicotinate and isoquinoline salts October 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01487E, CommunicationJun-Ju Mai, Fei Li, Xiasen Dong, Mingyuan Shi, Xiao-Jing Li, Hua-Dong Xu, Mei-Hua Shen, Chi-Fan ZhuCopper-catalyzed dearomative alkynylation of N-alkyl pyridinium/isoquinolinium salts with terminal alkynes affords 1,6-dearomatized products in high yield and selectivity under mild conditions.To cite this article before page numbers are assigned, use the DOI form […]Jun-Ju Mai
- Correction: Silver-catalyzed synthesis of polyfunctionalized 1,7- and 2,7-benzonaphthyridine scaffolds and access to perlolidine derivatives October 30, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90140E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kirti Vashishtha, Kapil Chahal, Namita Bhoi, Donamol Tomy, Balasubramanian Sridhar, Manjula Alla, Kallu Rajender ReddyTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Kirti Vashishtha
- Ortho-C‒O arylation of aromatic amides with Grignard reagents through Meyers reaction October 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01418B, CommunicationYa Wu, Bohao Wang, Yiran Shi, Pei Liu, Jie KongThe ortho-C‒O arylation arylamides is a step-efficiency and straightforward approach for the construction of biphenyl amides but has remained a great challenge. Herein, we report an efficient ortho-C‒O arylation of...The content of this RSS Feed (c) The Royal Society […]Ya Wu
- Heterocyclic Scaffold-Fused Dimethoxy-Dibenzocyclooctynes for Photoactivatable Click Chemistry October 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01314C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nils Alfred Larsson, Taegeun Jo, Ulf Bremberg, Stefano Crespi, Luke R Odell, Daniel FürthDibenzocyclooctynes (DBCOs) are widely used in bioorthogonal chemistry for strain-promoted azide–alkyne cycloaddition (SPAAC), but generally lack reactivity toward inverse-electron-demand Diels–Alder […]Nils Alfred Larsson
- Reactivity study of 4-hydroxy-2H-chromene-2-thiones with symmetrical 1,4-acetylene dicarboxylates and methyl propiolate using ytterbium(III) triflate as catalyst: stereoselective synthesis of substituted fumarate and (Z) acrylate derivatives October 29, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB01518A, PaperEman Ali SK, Abu Taleb KhanStereoselective hydrothiolation of symmetrical 1,4-acetylene dicarboxylates with 4-hydroxy-2H-chromene-2-thione and its derivatives was carried out using 10 mol% Yb(OTf)3 in toluene at 100 °C to yield (58-83%) substituted fumarate derivatives.To cite this article before page numbers are assigned, use the DOI form of citation […]Eman Ali SK
- H-bonding, not remote participation, explains the influence of remote substituents on stereoselectivity in α-galactosylations November 5, 2025
