RSC – Org. Biomol. Chem. latest articles- Design and Synthesis of Thiophene-Based C 2 -Symmetric Chiral Phosphoric Acids on a Decahydroquinoxaline scaffold for Stereoselective Transformations March 31, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00309E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Margherita Gazzotti, Vincenzo M Abbinante, Fabrizio MEDICI, Sara Ghirardi, Sergio Rossi, Tiziana Benincori, Roberto Cirilli, Maurizio BenagliaIn this study, the design and the synthesis of a thiophene-based phosphoric acid based on a chiral […]Margherita Gazzotti
- Developing tedizolid analogues as a new class of herbicides March 31, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00242K, CommunicationCaleb Hewlett, Aleksandra Debowski, Karen Deane, Keith StubbsThe oxazolidinone antibiotic class has been shown to be a promising scaffold for developing new herbicides. Here we use tedizolid, a known antibiotic, as a scaffold for herbicide development. Tedizolid...The content of this RSS Feed (c) The Royal Society of ChemistryCaleb Hewlett
- KBr-Enabled electrochemical transformation of alkynes into α-bromoketones/1,2-diketones March 31, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00329J, CommunicationYulin Li, Siyu Lei, Yuexia ZhangIn recognition of the crucial role of ketone motifs in significant organic transformations and the synthesis of valuable molecules (e.g., pharmaceuticals, pesticides, and fine chemicals), we herein report an electrochemical...The content of this RSS Feed (c) The Royal Society of ChemistryYulin Li
- tert-Butanol as an isobutene equivalent in the IED-HDA reaction of in situ-generated oxindole-embedded o-QMs March 31, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00274A, PaperJia-Cheng Ge, Xiangyun Kong, Yao-Bin Shen, Fangzhi Hu, Li-Jun Peng, Shuai-Shuai LiAn FeCl3-promoted aerobic IED-HDA reaction of in situ-generated oxindole-embedded o-QMs has been reported, in which tert-butanol serves as an ideal equivalent of gaseous isobutene, enabling efficient access to 2,2-dimethylchromane spirooxindoles.To cite this article before page numbers are […]Jia-Cheng Ge
- Enantioselective synthesis of chiral organoborons via carbene B-H insertion catalyzed by engineered neuroglobin March 30, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00282J, CommunicationXin Shan, Lijuan Sun, Huamin Wang, Shu-Qin Gao, Ying-Wu LinThe heme-containing globin, neuroglobin (Ngb), was engineered to catalyze enantioselective carbene B-H insertion reaction, affording chiral organoboron compounds up to 66% yield and 97:3 e.r. The rationally designed quadruple mutant,...The content of this RSS Feed (c) The Royal Society […]Xin Shan
- Photocatalytic C–H amination of electron-rich arenes by novel fused quinoline-based photocatalysts March 30, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00270F, PaperQian Shu, Dinghao Li, Siyu Zheng, Xue-Lian Lu, Bing Sun, Fang-Lin ZhangA range of fused quinoline-based photocatalysts were designed via the Povarov reaction. Upon in situ protonation with protic acid, these photocatalysts catalyze the C(sp2)–H amination of electron-rich arenes with azoles.To cite this article before page numbers are […]Qian Shu
- Photoinduced FeCl₃-Catalyzed α-C(sp³)-H Azolation of Primary Aliphatic Alcohols via LMCT-Driven HAT March 30, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00200E, PaperWeikun Zeng, Shuyan Zhan, Rong Huang, Mingquan Yuan, Jianqiang Zhang, Yi JinHerein, a visible-light-driven FeCl₃-catalyzed α-C(sp³)-H azolation/coupling reaction of primary aliphatic alcohols has been reported. The reaction achieves activation of the α-C(sp 3 )-H bond in the ether formed by dehydration...The content of this RSS Feed (c) The […]Weikun Zeng
- Dual Photoredox and Palladium Catalysis Enabled Cyclization Reactions March 30, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00243A, Review ArticleXiangqian Zhao, Qi-Yan Lv, Erqing Li, Kai Sun, ZhongYan Cao, Hang Fan, Bing YuOver the past decades, light-promoted organic reactions have established themselves as powerful tools in synthetic chemistry. Notably, the integration of photocatalysis with palladium catalysis has demonstrated significant potential in enabling...The content of this RSS […]Xiangqian Zhao
- Electrochemical direct site-selective selenation of carbazoles March 27, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00206D, PaperHaodong Ma, Wei Xu, Haomin Chen, Bin Wang, Ziren Chen, Yu Xia, Shaofeng Wu, Weiwei Jin, Chenjiang Liu, Yonghong ZhangAn electrochemical direct site-selective selenation of carbazoles has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Haodong Ma
- Expediated synthesis of N-acyl-N-alkyl sulfonamide probes for protein proximity labelling March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00339G, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Phathu Masithi, Laetitia Raynal, Peter O'Brien, Christopher D. SpicerN-Acyl-N-alkysulfonamides (NASAs) can be used to site-selectively label proteins via proximitymediated reactions. However, the synthesis of NASA probes can be challenging, typically using a two-step […]Phathu Masithi
- Metabolic Labeling and Imaging of Native Saccharomyces Cerevisiae Glycan by Using N-Acetylglucosamine-6-Phosphate Analogs March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00192K, PaperNianci Li, Jiaxin Feng, Shuhui Ji, Bin Fu, Hui Zhang, Tianyou Jiao, Qichan Yi, Nicholas Gong, Yimei Guo, Huijuan Ji, Yishu Yan, Pan Zhu, Jialin Liu, Yuntao ZhuN-acetylglucosamine (GlcNAc) is an essential component of fungal glycans, which are found in N-linked glycans, chitin polysaccharides in the cell wall, […]Nianci Li
- Metal Triflimide-Mediated Acylation of Sulfonamides and Transacylation of N-Acylsulfonamides † March 26, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00269B, PaperShimin Yang, Ying Peng, Shujie Li, Juan Tian, Dayong SangA method for the acylation of sulfonamides and transacylation of N-acylsulfonamides has been developed. The acylation proceeds smoothly in the presence of Cu(NTf2)2 (0.1 mol%) using carboxylic anhydrides, acyl chlorides,...The content of this RSS Feed (c) The Royal Society […]Shimin Yang
- Ultrafast fluorescent detection of mercury(II) ions in aqueous and biological systems using a boronic acid-based reaction probe March 26, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00170J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kishor Khadka, Sumita Subedi, Eun-Taex Oh, Keun-Hyeung LeeA phenylboronic acid-based fluorescent probe enables rapid fluorescence detection of Hg2+ by an irreversible reaction between Hg2+ and a phenylboronic acid moiety via a unique intermolecular […]Kishor Khadka
- Rh(III)-Catalyzed Cascade C-H Activation/Amination Enables the Synthesis of 1,2-Disubstituted Benzimidazoles from Amidines and Arynes March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00074F, CommunicationFen Xu, Shi-Yu Zhang, Jia-Qi Huo, Fan-Wang Zeng, Fu-Kang Zhou, Luciano BarboniBenzimidazoles are versatile and indispensable scaffolds widely used in organic synthesis. Herein, we report a Rh(III)-catalyzed cascade C-H activation/amination reactions between amidines and arynes, enabling the efficient synthesis of 1,2-disubstituted...The content of this RSS Feed (c) The […]Fen Xu
- Affinity enhancement of polo-like kinase 1 polo-box domain-binding peptides by N-methylation and lipidation March 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00193A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kohei Tsuji, Kenan Bai, Xueyuan Huang, Hirokazu TamamuraSynthesized Plk1 PBD-binding peptides with N-methylation exhibited up to 4-fold improved PBD affinities and with lipidation demonstrated up to 260-fold improved PBD affinities as compared with […]Kohei Tsuji
- Rapid Catalyst-Free Synthesis of α-Selenomethyl Ketones from Sulfoxonium Ylides and Selenols † March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00428H, PaperXuyang Gong, Huaiyu Huang, Taiwen Li, Qichen Liu, Xiaoqiong Fu, Haifeng Wang, Hao Zhoud, Shuangxi GuA rapid and catalyst-free synthesis of α-arylselenomethyl ketones has been developed via the direct coupling of sulfoxonium ylides with benzeneselenol. This metal-free protocol operates under mild conditions, exhibits excellent functional...The content of this […]Xuyang Gong
- Cycloaddition of Benzo[d]thiazoles with Imidazol-4-one Activated Donor-Acceptor Cyclopropanes. Synthesis of Spirocyclic Inhibitors of HIV-1 March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00180G, CommunicationViktoria A. Ikonnikova, Olga Shchigal, Andrey Anisenko, Pavel N. Solyev, Grigory A. Krylkov, Alexander R. Romanenko, Alexander Korlyukov, Mikhail S. Baranov, Marina Gottikh, Andrey A. MikhaylovThe reaction of benzo[d]thiazoles with imidazol-4-one activated donor-acceptor cyclopropanes (DACs) represents a practicable cycloaddition resulting in new spirocyclic compounds. DACs react with a […]Viktoria A. Ikonnikova
- Practical and robust access to enimides via DMAPO-catalyzed coupling of carboxylic acids with secondary enamides March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00367B, PaperXianghe Wu, Feng Yu, Li Zhang, Yewen FangHerein, a new protocol for the preparation of α-aryl N-vinylimides has been successfully developed. With carboxylic acids as the acyl source, a range of N-vinylamide could react with carboxylic acids...The content of this RSS Feed (c) The Royal Society of ChemistryXianghe Wu
- Betaine–ZnO hybrid catalyst: a sustainable bifunctional system for solvent-free Knoevenagel condensation March 25, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D6OB00300A, PaperLema Deme Shumi, Mateusz Pilszek, Magdalena Grabowska, Sebastian Jurczyk, Dariusz Łukowiec, Piotr LatosA sustainable betaine–ZnO hybrid catalyst was synthesized via a simple mixing approach between betaine hydrochloride and zinc oxide.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Lema Deme Shumi
- Recent Advances in Organocatalytic Enantioselective Construction of Alkynyl-Containing Tetrasubstituted Carbon Stereocenters March 25, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D6OB00306K, Review ArticleJiaying Yin, Yu Li, Junbing LinAlkynyl-containing tetrasubstituted carbon stereocenter represents a frequently encountered structural motif in a series of biologically active molecules. Furthermore, the presence of alkyne-containing tetrasubstituted carbon stereocenters in a molecule offers a...The content of this RSS Feed (c) The Royal Society of ChemistryJiaying Yin
- Design and Synthesis of Thiophene-Based C 2 -Symmetric Chiral Phosphoric Acids on a Decahydroquinoxaline scaffold for Stereoselective Transformations March 31, 2026
