RSC – Org. Biomol. Chem. latest articles- High-yielding Total Synthesis of Embelin, Rapanone, and Irisoquin A, D, F January 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01706D, PaperEtikala Ashok, Pandhiti R. Lakshmi, Shyam D. Sanwal, Dhevalapally B. RamacharyA simple and sustainable three- and four-step sequences of di-OH-protection/mono-OMe-deprotection/OrgRC and di-OH-protection/mono-OMe-deprotection/OrgRC/OMe-deprotection protocols were developed to construct biologically active natural products of irisoquin, irisoquin A, irisoquin D, irisoquin F, sorgoleone-364,...The content of this RSS Feed (c) The Royal […]Etikala Ashok
- Regioselective synthesis of 5-azaindazoles based on the intramolecular amination reaction of 5-acyl-4-pyridones with hydrazines January 16, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01969E, Paperviktoria Vladimirovna Viktorova, Dmitrii L'vovich Obydennov, Аlsu F. Mustafina, Maria V. Ulitko, Mikhail Yurievich Kornev, Vyacheslav SosnovskikhThe labile tautomerism of N-unsubstituted 5-acyl-4-pyridones, which exist in the form of 4-pyridone or 4-hydroxypyridine depending on the solvent, has been demonstrated. This equilibrium determines reactivity of pyridones and ability...The content of […]viktoria Vladimirovna Viktorova
- Correction: A novel platinum(II) complex with a berberine derivative as a potential antitumor agent targeting G-quadruplex DNA January 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90007G, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shu-Lin Zhang, Haimei Fu, Yingxia Ma, Qifu Lin, Yanli Xu, Qiyuan Yang, Peng He, Zuzhuang WeiTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Shu-Lin Zhang
- A silicon rhodamine 1,2-dioxetane chemiluminophore for in vivo near-infrared imaging January 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB02002B, CommunicationRokia Osman, Uroob Haris, Maidileyvis C. Cabello, Ralph Mason, Alexander R. LippertNear-infrared (NIR) chemiluminescent probes have attracted increasing attention in recent years due to their attractive properties for in vivo imaging. Herein, we developed a NIR chemiluminophore silicon rhodamine (SiRCL-1) based...The content of this RSS Feed (c) The […]Rokia Osman
- Dichlorination of olefins with trichloroisocyanuric acid (TCCA) and tetrabutylammonium chloride (TBACl) January 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01962H, PaperRamazan KoçakA new metal-free, molecular chlorine-free, environmentally friendly, atom-economical, short time, inexpensive and simple operation method with mild reaction conditions for chlorination of olefins was reported using TCCA and TBACl.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Ramazan Koçak
- Copper (I) Catalyzed Coupling of Alkynyl Glycosides: Synthesis of Buta 1,3-Diyne Linked Disaccharides and Dinucleosides January 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01872A, CommunicationJunaid Banday, Sajjad Ahmed, Qazi Naveed AhmedHerein we report copper-catalyzed coupling of alkynyl glycosides facilitating the synthesis of buta 1,3 diyne linked disaccharides. The reaction is characterized by mild conditions, employing eco-friendly reagents resulting in good...The content of this RSS Feed (c) The Royal Society of ChemistryJunaid Banday
- Direct Organocatalytic Chemoselective Synthesis of Pharmaceutically Active Benzothiazole/Benzoxazole-Triazoles January 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01527D, PaperBadaraita Gorachand, Pandhiti R. Lakshmi, Dhevalapally B. RamacharyBenzothiazole and benzoxazole heterocyclic rings containing 1,4,5-trisubstituted-1,2,3-triazoles are well-known for their wide range of applications in pharmaceutical and medicinal chemistry, but their high-yielding metal-free selective synthesis has always remained challenging,...The content of this RSS Feed (c) The Royal Society of ChemistryBadaraita Gorachand
- Preparation of ethynylsulfonamides and study of their reactivity with nucleophilic amino acids January 15, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01873G, PaperTatsuhiro Kyoya, Hiroaki Ishida, Toshiaki Saitoh, Toshimasa ItohA facile synthesis for ethynylsulfonamides was developed, and reactivity of the ethynylsulfonamides with cysteine was enhanced in PBS. Propynylsulfonamides show promise as suitable Michael acceptors for selective bioconjugation with cysteine.To cite this article before page numbers are assigned, use the DOI […]Tatsuhiro Kyoya
- Facile synthesis of the unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-propargyl β-enaminones January 15, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01884B, PaperElif Serel Yılmaz, Kerem Kaya, Metin ZoraIn this paper, we have uncovered a new reaction of N-homopropargylic β-enaminones, i.e. N-(4-phenyl-3-butynyl)-β-enaminones. When subjected to the reaction with excess molecular iodine or N-iodosuccinimide in the presence of cesium...The content of this RSS Feed (c) The Royal Society of ChemistryElif Serel Yılmaz
- BF3·Et2O-promoted unconventional reactions of 2-oxoaldehyde: access to 4-amidooxazoles and β-keto amides/sulphonamides January 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01956C, CommunicationAshiq Hussain Padder, Bhawna Ghora, Feroze Hussain, Mohammad Yaqoob Bhat, Qazi Naveed AhmedThis study investigates the potential of boron trifluoride etherate (BF3·OEt2) to trigger unprecedented reactions of 2-oxoaldehydes with nitriles and amides/sulphonamides.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Ashiq Hussain Padder
- Recent Progress in C–S Bond Formation via Electron Donor-Acceptor Photoactivation January 14, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01951B, Review ArticleSi-Chang Wang, Liting Wang, Jin Cui, Liying Zhang, Qunzheng Zhang, Congyu Ke, Shenlin HuangRecent advancements in C–S bond formation via electron donor-acceptor (EDA) photoactivation have been highlighted. EDA complexes, which composed of electron donors and acceptors, facilitate C–S bond construction under mild conditions...The content of this RSS […]Si-Chang Wang
- Genome mining and heterologous expression reveal streptacidin, a new lasso peptide from Streptacidiphilus jiangxiensis January 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01998A, PaperJiwu Huang, Botao Cheng, Chunyang Cao, Wen LiuWe heterologously produced a type II lasso peptide gene cluster that was mined from Streptacidiphilus jiangxiensis in E. coli. Streptacidin is the first lasso peptide documented to maintain its 3D structure with methionine as a steric lock.To cite this article before […]Jiwu Huang
- Copper-catalysed radical cascade reaction of N-(2-oxo-2-phenylethyl) substituted 2-pyridones with styrene to access 1,6-carboannulated 2-pyridone scaffolds January 14, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01965B, CommunicationShengkui Jin, Liqiang Hao, Cunneng Li, Xian Liu, Xiao Yu, Jiaqian Mao, Dong Ding, Yafei JiHerin, we present a DTBP-mediated 3 + 2 cycloaddition reaction between N-(2-oxo-2-phenylethyl) substituted 2-pyridones and styrene; this reaction can afford 1,6-carboannulated 2-pyridone scaffolds with up to 79% yields.To cite this article before page […]Shengkui Jin
- Halonium and Chalconium Salt-Catalyzed Schiff Condensation: Kinetics and DFT Insights into Organocatalyst Activity Parameters January 13, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01798F, PaperAlexandra A. Sysoeva, Yana V. Safinskaya, Mikhail Il'in, Alexander S. Novikov, Dmitrii BolotinSchiff condensation between 4-methylbenzaldehyde and 2-aminopyridine, catalyzed by chloronium, bromonium, iodonium triflates, as well as sulfonium, selenonium, and telluronium triflates, was investigated. ¹H NMR monitoring revealed that the catalytic activity...The content of this RSS Feed (c) […]Alexandra A. Sysoeva
- Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines January 11, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01985G, PaperAo-Yun Li, Rong Xie, Quan Zhou, Peng-Fei Huang, Yu LiuA photochemical radical cascade cyclization reaction of isocyanides with α-carbonyl bromides under mild conditions is disclosed for accessing 1,4-dibenzodiazepines, demonstrating good tolerance towards various functional groups.To cite this article before page numbers are assigned, use the DOI form of […]Ao-Yun Li
- DBU-catalyzed annulation strategy for modular assembly of 2,3-difunctionalized dihydrobenzofurans January 10, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01406E, CommunicationLili Yuan, Jie Wang, Qiang Tang, Yiping Wang, Beibei Ma, Yongjia Shang, Xinwei HeWe have developed an organocatalytic approach for the construction of a 2,3-dihydrobenzofuran scaffold through a formal [4 + 1] annulation of 2-(2-nitrovinyl)phenols and α-bromoacetophenones in the presence of DBU.To cite this article before page numbers […]Lili Yuan
- Photocatalyst-free formate-mediated C-O cleavage by EDA complex and SCS strategy for synthesis of diaryl 1,4-diketone in air January 10, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01913J, CommunicationMolai Zhao, Yutong Liu, Xueqin Chen, Min Peng, Ya-Wen Wang, Xiang-Wei Liu, He Zhong Jiang, Rui Tan, Jiahong LiUnder mild visible light conditions, formates facilitate C-O cleavage via the EDA complex and SCS strategy, yielding the α-carbonyl alkyl radicals. This radical then reacts with olefins under air condition,...The […]Molai Zhao
- Nickel(II)-hydrazineylpyridine catalyzed regioselective synthesis of α-benzyl substituted β-hydroxy ketones via a Fenton free radical reaction January 10, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01840K, PaperApurva Singh, Naseem AhmedNi-PyH-catalyzed regioselective synthesis of α-benzyl substituted β-hydroxy ketones is reported via a Fenton free-radical reaction. Protocol enables facile access to products in good to excellent yields in toluene at room temperature to 100 °C.To cite this article before page numbers are assigned, use the DOI […]Apurva Singh
- Scalable Synthesis of (±)-Gregatin A via 1, 3-dipolar Cycloaddition Strategy January 10, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB02108H, CommunicationYiming Ding, Xiaoli Zhao, Qu Chunlei, Xianwen Long, Yaqiu Zhao, Jun DengA 6-step gram-scale synthesis of fungal polyketide (±)-gregatin A was described. The synthetic route features an intermolecular 1,3-dipolar cycloaddition, a Mo-mediated disconnection of isoxazole skeleton, and an acid-mediated deprotection/enamine hydrolysis...The content of this RSS Feed (c) The […]Yiming Ding
- Strain-promoted azide-alkyne cycloaddition enhanced by the secondary interactions† January 10, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01752H, CommunicationRiko Yoshikawa, Shohei Hamada, Jun-ichi MatsuoAzide-alkyne cycloaddition of cyclooct-2-yn-1-ol and 2-(azidophenyl)boronic acid proceeded rapidly at room temperature with complete regioselectivity to afford a triazole having a boronate ester group. The secondary covalent interaction of the...The content of this RSS Feed (c) The Royal Society of ChemistryRiko Yoshikawa
- High-yielding Total Synthesis of Embelin, Rapanone, and Irisoquin A, D, F January 16, 2025
