RSC – Org. Biomol. Chem. latest articles- PyBroP/base-promoted one-pot three-component sequential decarboxylative addition reaction of β-keto acids, isatylidene malononitriles and pyridine N-oxides January 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01772F, PaperFuzhong Han, Yingdong Na, Lina Jia, Xiang-Ping HuA PyBroP/base-promoted three-component sequential decarboxylative nucleophilic addition protocol has been developed. Under the optimized conditions, a wide array of β-keto acids, isatylidene malononitriles and pyridine N-oxides couple efficiently to deliver...The content of this RSS Feed (c) The Royal Society of ChemistryFuzhong Han
- Diastereoselectivity construction of spiro-cyclopropyl-pyrazoles via a [2+1] annulation reaction of iminoindoline-derived alkenes and 4-bromo-pyrazolons January 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01841B, PaperDan Hu, Heng Yin, Fuyu Li, Jiao He, Chenglong Deng, Lixia Liu, Wen Xia, Yu-Long Li, Chenyi LiA base-promoted [2+1] annulation reaction between iminoindoline-derived alkenes and 4-bromo-pyrazolons has been disclosed under mild conditions, affording a series of novel, pharmaceutically-interesting spiro-cyclopropyl pyrazolones containing indolines in good to excellent...The content […]Dan Hu
- Four-Component Assembly of Polysubstituted Pyrimidines via Dual C(sp3)-H Functionalization of Primary Aliphatic Amines January 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01866H, CommunicationKang Liu, Jiaoling Li, Sichen Xu, Xi Zhang, Xue Peng, Yao-Fu Zeng, Xinping Liu, Ying Peng, Zhen Wang, Jinjin ChenAn efficient iodine-promoted four-component reaction has been developed for the synthesis of diverse polysubstituted pyrimidines. The multicomponent strategy utilizes primary aliphatic amines as C-C-N synthons, aromatic aldehydes as the […]Kang Liu
- BF3·Et2O-catalyzed dearomative spirocyclization of ynones for the synthesis of spirolactams and spirolactones January 6, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01826A, CommunicationYu Zhao, Jingfu Zhu, Quanye Liu, Kangyi Li, Shu Chen, Yu Cheng, Wei Li, Di WuThis metal-free catalytic system achieves highly efficient and selective synthesis of spiro-γ-lactams and spiro-γ-lactones under mild conditions, while demonstrating excellent tolerance toward diverse substituents and heteroaromatic rings.To cite this article before page numbers […]Yu Zhao
- Iron-catalyzed Oxidative Cleavage of C-N Bonds of Tertiary Amines: Syntheses of Unsymmetrical Ureas from Isocyanates January 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01697E, PaperBumairemu Aizezi, Bulunuer Yusan, Pinchang Sun, Abudureheman WusimanAn iron-catalyzed protocol has been developed for the synthesis of unsymmetrical ureas via a cascade of oxidative C–N bond cleavage of tertiary amines and hydroamination of isocyanates. This strategy employs...The content of this RSS Feed (c) The Royal Society of ChemistryBumairemu Aizezi
- Synthesis of carbazoles via aryl C–H activation triggered by surfactant-associated palladium nanoparticles under microwave-assisted heating in aqueous medium January 6, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01749A, PaperSafiul Alam, Aminur Khan, Asifur Rahaman Mallick, Samiul Islam, Abhimanyu Sarkar, Bibhutibhushan Show, Jakir Ahmed, Amit Kumar, Antoine Maruani, Hamid DhimaneHerein, we present a novel and environmentally friendly method for synthesizing carbazoles relying on palladium catalysis in water as a green reaction medium. The process utilizes surfactant-associated palladium […]Safiul Alam
- Design, Synthesis, and Structural Analysis of an Inhibitor of the Gastric Proton Pump with a Diaza-tricyclic Skeleton January 5, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01828E, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nariyoshi Umekubo, Airi Hashizume, Haruki Saito, Satoru Kato, Chisato Kanai, Chai Chandru Gopalasingam, Christoph Gerle, Hideki Shigematsu, Atsushi Yoshimori, Kazuhiro Abe, Satoshi YokoshimaThe development of potent K + -competitive acid blockers (P-CABs) as […]Nariyoshi Umekubo
- Convergent synthesis of quinoxalinone-pyridine scaffolds via C3-H alkenylation of quinoxalin-2(1H)-ones with Hantzsch esters and its in-silico studies January 5, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01795E, PaperSaurabh Kumar, Amit K. Pathak, Uma Devi Newar, Abhimanyu Nayak, Monjuri Bora, Hrishikesh Sarmah, Subrata Ghosh, Ram Awatar MauryaA novel and efficient method for the C3-H alkenylation of quinoxalin-2(1H)-ones has been developed using trifluoroacetic acid (TFA) as a Brønsted acid catalyst and Hantzsch esters (HEs) as the alkenylating...The […]Saurabh Kumar
- A computational investigation of the thermal elimination chemistry of β-borylated sulfoxides. Sulfenic acid vs. boryl sulfenate elimination January 5, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01455G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eric A. Nicol, Adrian L. SchwanComputational analysis reveals that boryl substituents lower barriers for the classical Ei reaction of sulfoxides leading to sulfenic acids and olefins; however, the preferred elimination is that of […]Eric A. Nicol
- TMEDA-Catalyzed Synthesis of Pentasubstituted 2-Aminopyrroles from Ynehydrazides and Dialkyl Acetylenedicarboxylates January 5, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01825K, CommunicationZhiwei Zeng, Jingwei Lin, Yongchao Xie, Jiangbin Guo, Nan Ma, Jian Lei, Lin Jinguo, Xiaolan XieHerein, we report a mild and highly atom-economic synthesis of pentasubstituted 2-aminopyrroles from ynehydrazides and dialkyl acetylenedicarboxylates under ambient conditions. This transformation proceeds through a tandem sequence that combines conjugate...The content of this […]Zhiwei Zeng
- Use of homoserinyl γ-aldehyde–containing peptides in solid-phase reductive amination January 5, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01718A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dimitrios Tolis, Dimitra Magkafa, Spyridon MourtasSide-chain–deprotected homoserinyl (Hse) peptides are converted into γ-aldehydes and engaged in solid-phase reductive amination.To cite this article before page numbers are assigned, use the DOI form of citation […]Dimitrios Tolis
- Optically active dihydro-1,4-benzoxazines: synthetic, separation, and enzymatic approaches January 5, 2026Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01724F, Review ArticleBenjamin Coquelle, Hong-Ngoc Pham, Axelle Arrault, Samir AcherarAsymmetric and chemoenzymatic syntheses, kinetic resolution and chiral HPLC enantioseparation enable access to optically active dihydro-1,4-benzoxazines, an important class of biologically active heterocycles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Benjamin Coquelle
- pH Related Activity and Reaction Mechanism of CatA: A DFT Study January 5, 2026Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01513H, PaperBerkehan Kura, Nurcan Senyurt TuzunCathepsin A (CatA) is a human form serine type carboxypeptidase enzyme which functions optimally around pH 4-5 and displays deamidase/esterase activity at elevated pH levels around 7-8. The activity of...The content of this RSS Feed (c) The Royal Society of ChemistryBerkehan Kura
- Metal-free quinoline synthesis via Brønsted acid-promoted cyclization of ene-ynamides December 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01680K, PaperYijie Wang, Yu Li, Lisha Zhang, Junbiao Chang, Xiao-Na WangWe report a metal-free strategy for the efficient synthesis of polysubstituted quinolines via Brønsted acid-promoted cyclization of readily accessible ene-ynamides. Promoted by stoichiometric TfOH under mild conditions (30 °C), this...The content of this RSS Feed (c) The Royal Society […]Yijie Wang
- Base-dependent divergent α-cyanation and pyridylation of tertiary amines with cyanoaromatics † December 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01754H, CommunicationKai Ge, Yezhe Zhao, Haowen Dang, Min Wang, Jiabin ShenDivergent synthesis has emerged as a powerful and economical approach in synthetic chemistry. Herein, we show a basedependent divergent photochemical C-C coupling reaction of tertiary amines with cyan aromatic. Remarkably,...The content of this RSS Feed (c) The Royal Society […]Kai Ge
- Determinants of undesired α2-6-sialoside formation by PmST1 M144D December 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01796C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Fahima Mozaneh, Maju Joe, Warren Wakachuk, Peng Wu, Matthew S MacauleySialyltransferases catalyze the regioselective glycosidic bond formation between sialic acid and a glycan acceptor. Pasteurella multocida α2-3-sialyltransferase 1 (PmST1) is a widely used […]Fahima Mozaneh
- Recent advances in tert-butyl nitrite-mediated nitration cyclization/spirocyclization reactions December 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB01761K, Review ArticlePu Guo, Yunfei Tian, Luping Zheng, Xiaojun Li, Mengyun Niu, Weijun Fu, Yuzhen Zhao, Zejiang LiNitro-functionalized compounds and their derivatives have attracted considerable attention because of their synthetic value/special biological activities. Direct cascade cyclization reactions of unsaturated hydrocarbons with nitro-reagents are of particular interest to...The content of […]Pu Guo
- Recent advances in Pd-catalysed decarboxylative asymmetric allylic alkylation December 24, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01686J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Niamh Lehane, Patrick J. GuiryThis review collates recent developments of this transformation. Selected examples of this methodology being applied in natural product synthesis are given, along with details of our current understanding […]Niamh Lehane
- Synthesis-enabled conformational assignment of natural N-acyl L-phenylalanine derivatives from freshwater sponge–associated Micromonospora sp. MS-62 December 23, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01886B, CommunicationJiyool Kim, Jueun Kang, Yongseong Han, Jinchan Sim, Young-Tae Park, Young-Joo Kim, Jaeyoung Kwon, Ja Young Cho, Taejung KimConcise total synthesis of N-acyl-L-phenylalanine derivatives from Micromonospora sp. MS-62 confirming S configuration by X-ray analysis.To cite this article before page numbers are assigned, use the DOI form of citation […]Jiyool Kim
- High-throughput DoE synthesis of chalcones and pyrazolines for fluorescent sensing December 23, 2025Org. Biomol. Chem., 2026, Advance ArticleDOI: 10.1039/D5OB01684C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander CiupaPyrazolines are attractive scaffolds for fluorescent sensors due to their unique photophysical properties and the ease of their synthesis from chalcone precursors.To cite this article before page numbers are assigned, use the […]Alexander Ciupa
- PyBroP/base-promoted one-pot three-component sequential decarboxylative addition reaction of β-keto acids, isatylidene malononitriles and pyridine N-oxides January 6, 2026
