RSC – Org. Biomol. Chem. latest articles- Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process：modular access to functionalized α-(hetero)aryl-α-aminoketones March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00290G, CommunicationHaibo Huang, Yu Zhao, Li Zhang, Yan Li, Yewen FangHerein, using reductive radical-polar crossover as a key process, a robust and practical protocol dealing with N→C acyl migration reaction has been successfully developed. A range of enamides could react...The content of this RSS Feed (c) The Royal Society […]Haibo Huang
- Organocatalytic Cyclization-Rearrangement Cascade Reaction: Asymmetric Construction of γ-Lactams March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00010F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sheng-Feng Wu, Zhi-Yuan Wang, Xing-Wen SunWe report a chiral thiourea-catalyzed Michael/ring-reorganization cyclization of 3-methyleneoxindoles with N-(p-toluenesulfonyl)-α-amino ketones, facilitating the asymmetric synthesis of γ-lactams. This method efficiently generates a range of optically pure γ-lactams, […]Sheng-Feng Wu
- A Versatile Approach to the Enantiospecific Synthesis of Sugar-Linked Oxapolyquinanes via IPKR March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB02016B, PaperKanchan Maurya, Krishna P. KaliappanAn efficient and enantiospecific synthetic strategy for the construction of [6/5/5/5] and [5/5/5/5] fused oxatetraquinanes, using a D-glucose-derived enyne has been described. The approach integrates oxidative cleavage, organoaluminium-mediated propargylation, and...The content of this RSS Feed (c) The Royal Society of ChemistryKanchan Maurya
- Palladium-Catalyzed Regio- and Enantio-selective Trifluoromethylated Allylic Alkylation of Diphenylphosphine Oxides March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00096C, PaperShuaibo Zhang, Yunzhe Liu, Luyang Sun, Bangzhong Wang, Jinfeng Zhao, Jingping Qu, Yuhan ZhouThe first and convenient method of allylic alkylation of diphenylphosphine oxides catalyzed by palladium was designed and developed, affording various chiral allylphosphine oxide bearing CF3 group with exclusive regio-selectivity and...The content of this RSS Feed […]Shuaibo Zhang
- Kinetic Resolution of Binols and Biphenols via Dehydrogenative Coupling with Hydrosilanes Catalyzed by Chiral FLPs March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00347D, CommunicationZijia Zhang, Xiangqing Feng, Haifeng DuA kinetic resolution of binols and biphenols has been realized via the dehydrogenative coupling with hydrosilanes catalyzed by a frustrated Lewis pair of chrial borane and chiral phosphine. A variety...The content of this RSS Feed (c) The Royal Society of ChemistryZijia Zhang
- One-pot four-component olefin 1,2-Se (S) bifunctionalization: efficient synthesis of β-selenylethyl dithiocarbamates March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00248F, PaperHong Yang, Gaowen Ren, Zhang-Gao Le, Zong-Bo XieA one-pot, four-component reaction for simultaneously constructing C–Se, C–S, and C–N bonds via iron-mediated olefin 1,2-bifunctionalization is described. β-Selenylethyl dithiocarbamates were obtained highly efficiently with good functional-group tolerance, broad substrate...The content of this RSS Feed (c) The Royal Society of ChemistryHong Yang
- Photoswitchable agonists for visible-light activation of the Wnt signaling pathway March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB01827C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shifa Ahmad, P. K. Hashim, Masamichi Imajo, Nusaiba Madappuram Cheruthu, Kiyonori Takahashi, Shinya Tanaka, Takayoshi Nakamura, Nobuyuki TamaokiBased on a known Wnt agonist BML-284 we designed and synthesized photoswitchable azo derivatives that act […]Shifa Ahmad
- Electrochemically Driven Reductive Cyclization of o-Nitroanilines: Synthesis of 1,2-Fused Benzimidazole and Benzo[d]imidazole March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00214A, PaperJutamart Saetan , Nitchakan Purahong , Kannika La-ongthong, Nattawoot Hassa , Nawasit Chotsaeng, Chutima Kuhakarn, Jatuporn MeesinThe electrochemical synthesis of 1,2-fused benzimidazoles and benzo[d]imidazoles from o-nitroanilines in an undivided cell under constant current conditions was developed. The electrosynthesis proceeded through a tandem process involving nitro reduction/C(sp3)‒H...The content of […]Jutamart Saetan
- Combined antifungal nanocarriers based on self-assembled nystatin and pillar[5]arene with terpene moiety March 30, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00352K, PaperRustem Gamirov, Alan Akhmedov , Dmitriy Burdyugov, Yulia Panina, Mikhail Sergeevich Bukharov, Eugeniya Sokolova, Evgenia Subakaeva, Yulia Bukarinova, Pavel Zelenikhin, Dmitriy Shurpik, Ivan StoikovIn this study, nanocarriers based on self-assembled nystatin and pillar[5]arene were proposed. It was shown that pillar[5]arene with terpene moiety are capable of targeted delivery […]Rustem Gamirov
- On the divergent reactivity of allenylstannanes generated from the O-directed free radical hydrostannation reaction of (±)-trans-3-(2-phenylcyclopropyl)prop-2-yn-1-ol. EPR evidence for the reversible addition of Ph3Sn radicals to vinyl triphenyltins March 28, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01847H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.K. Lawrence E. Hale, Alistair J. Fielding, Karl J. HaleO-Directed hydrostannation of the probe 5 with Ph3SnH/cat. Et3B and O2 in PhMe gave rise to 23 and 24 in 67% yield. When studied […]K. Lawrence E. Hale
- A Novel Acenaphthoimidazolyidene Oxazolinic Palladium Complex and its Efficient Catalysis in Suzuki Cross-Coupling Reactions of N-Acyl-Glutarimides via N-C Cleavage March 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00279F, CommunicationQinyue Deng, Tenglong Lin, Xiaohu Liu, Han Shao, Xiaojun Lyu, Xiaoting Wu, Fei Xiong, Wanfang LiHerein we synthesized a new Pd–N-heterocyclic carbene (Pd-NHC) complex which featured an acenaphthoimidazolylidene (AnIm) skeleton and 2-phenyl-2-oxazoline. This catalyst exhibited extremely high efficiency in Suzuki–Miyaura couplings between N-acyl-glutarimides and organoboronic...The content of this […]Qinyue Deng
- Synthesis of indole-linked β-cyano-enones: a pathway to indolyl-2-pyrrolones March 27, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00328H, PaperNurabul Mondal, Vidya Kumari, Danish Ali, Lokman H. ChoudhuryThe multicomponent reaction of arylglyoxal, malononitrile, and indoles in DMF yields indole-linked β-cyano-enones, which serve as precursors for medicinally relevant 2-pyrrolones, 1,2-diketones, and quinoxalines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Nurabul Mondal
- Transition metal- and oxidant-free [3 + 2] cycloaddition of N-amino(iso)quinolinium salts with vinyl acetate as an acetylene surrogate March 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00289C, Communicationhui wu, Wenfeng Zhao, Nan Jiang, Mao Liu, Qingmei Ge, Hang CongA metal- and external oxidant-free [3 + 2] annulation of N-amino(iso)quinoline salts with vinyl acetate as acetylene surrogate under simple and mild reaction conditions was described. A series of valuable...The content of this RSS Feed (c) The […]hui wu
- Mn-Catalyzed oxo-alkylation of 1,2,4-triazine-3,5(2H, 4H)-diones with cyclic alkanols via oxidative cross-dehydrogenative-coupling March 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00098J, PaperQianqian Liang, Shuomeng Bai, Yushi Tan, Hong-Yu Zhang, Yuecheng Zhang, Jiquan ZhaoAn efficient and convenient pathway to synthesize diversified 3 or 4-oxo-alkyls substituted 1,2,4-triazine-3,5(2H, 4H)-diones has been reported via the atom- and step-economic cross-dehydrogenation coupling strategy with good functional group tolerance...The content of this RSS Feed (c) The […]Qianqian Liang
- Copper-catalyzed N-arylation of 1,2,4-oxadiazin-5(6H)-ones by diaryliodonium salts March 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00204D, PaperSofia Presnukhina, Svetlana O. Baykova, Elizaveta A. Chukanova, Nadezhda Metalnikova, Sergey Baykov, Natalia S. Soldatova, Pavel S Postnikov, Vadim BoyarskiyHere, we developed a new synthetic approach to the preparation of N-arylated 1,2,4-oxadiazin-5-(6H)-ones by direct arylation with diaryliodonium salts. The reaction with symmetrical diaryliodonium salts using CuI as a […]Sofia Presnukhina
- A review on benzoselenazoles: synthetic methodologies and potential biological applications March 26, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D4OB01897D, Review ArticleManisha Yadav, Vijay P. SinghThis review highlights the recent advances in the most current synthetic routes for benzoselenazoles and their biological properties, including antioxidant, antitumor, antibacterial activities and as inhibitors of pancreatic lipase.To cite this article before page numbers are assigned, use the DOI form of citation […]Manisha Yadav
- Visible-light-driven nickel-catalyzed reductive cross-coupling of benzyltrimethylammonium triflates with aryl bromides March 26, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00215J, CommunicationRen-Gui Tian, Mengyao Yu, Bo Ni, Muliang Zhang, Shi-Kai TianA visible-light-driven nickel-catalyzed cross-coupling of benzyltrimethylammonium triflates with aryl bromides was developed, enabling the direct synthesis of various diarylmethane products under mild conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Ren-Gui Tian
- Enhanced Ester Dechloroacetylation through Transesterification with Trimethoxyborane March 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00255A, CommunicationSheng Zhang, Xiangrong Wang, Renhua Li, Zhangrong Lou, Haoyun Zhan, Masahiko YamaguchiA new strategy to remove chloroacetyl group using B(OMe)₃ and K₃PO₄ in the presence of organophosphine is described. The reaction was performed on O-AcCl-protected benzylic, aliphatic primary, aliphatic secondary, allyl,...The content of this RSS Feed (c) The […]Sheng Zhang
- Ionic Liquids in C-H Activation: Synthesis and Functionalization of Heterocycles and Carbocycles March 26, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB02109F, Review ArticleKamal Kant, Priyadarshini Naik, Jyoti ., Nayyef Aljaar, Chandi Charan MalakarThis review illustrates various roles of ionic liquids in organic transformations such as solvents, pre-catalysts, and catalysts for the synthesis and functionalization of heterocycles and carbocycles through C-H activation reactions....The content of this RSS Feed (c) The […]Kamal Kant
- Rh(III)-catalyzed C–H alkenylation of NH-sulfoximine with vinylsilanes March 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00213C, CommunicationYu Gao, Ya-Li Xu, Lin DongThe rhodium(III)-catalysed ortho-C–H alkenylation of NH-sulfoximine using readily available vinylsilanes has been achieved. The vinylsilane groups can bes electively changed into a variety of substituents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Yu Gao
- Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process：modular access to functionalized α-(hetero)aryl-α-aminoketones March 30, 2025
