RSC – Org. Biomol. Chem. latest articles- Photocatalytic Three-component Reaction for Synthesis of Dithio-carbamates April 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00489F, PaperXin-Yu Mei, Hui-Lin Lu, Shi-Long Zhong, Bo-Jiang Chen, Zi-Wei Xi, Qiliang Yuan, Yong-miao ShenThis manuscript describes a visible light induced photocatalytic three-component reaction of an alkyl halide ([(iodomethyl) sulfonyl] benzene or arylmethyl bromide), carbon disulfide, and amine for the synthesis of dithiocarbamates under...The content of this RSS Feed […]Xin-Yu Mei
- Direct C-H Fluorination/Heteroarylation of Oxindoles with Quinoxalin-2(1H)-ones Using Selectfluor April 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00427F, PaperHui Qin, Guoliang Wei, Wen-Geng Xie, Xiaohong Mao, Fu-Wei Wang, Meihua Bao, Xiaowei Zheng, Yiwen Zhang, Ping HuangHerein, we present an efficient and feasible strategy for direct C-H fluorination and heteroarylation of oxindoles on C-3 position owning C(sp3)-H bond with quinoxalin-2(1H)-ones based on a radical coupling reaction...The content […]Hui Qin
- Construction of a 1,2-diazetidine core based on a multicomponent reaction of N,N′-(2,3-dimethylbutane-2,3-diyl)bis(hydroxylamine), arylglyoxals, and Meldrum's acid April 29, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00545K, PaperNadezhda A. Bakuleva, Boris V. Lichitskii, Andrey N. Komogortsev, Evgeny V. TretyakovIn the present paper we describe the first example of construction of a 1,2-diazetidine core based on vicinal bis(hydroxylamine).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Nadezhda A. Bakuleva
- Chemical modification of sialylated oligosaccharides to functionalize nanostructured lipid carriers: exploring two different strategies April 29, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00270B, PaperPaul Rivollier, Emeline Richard, Antoine Hoang, Aurélien Traversier, Manuel Rosa-Calatrava, Dorothee Jary, Isabelle Texier, Sebastien FortNanostructured lipid carriers (NLCs) are innovative lipid-based formulations made up of a carefully balanced mixture of solid and liquid lipids in their core. This unique architecture offers several advantages over...The content of this […]Paul Rivollier
- Silver-Catalyzed Generation of Acyl Radicals from α-Imino-Oxy Acids: Access to Acylated 3-CF3-2-Oxindoles April 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00262A, CommunicationYating Cao, Yushan Wei, Yingxin Hu, Daosheng Liu, Mengyao Liu, Jingjing Wang, Chong Li, Pinpin Wang, Liyan Hu, Feng LiA unified strategy to generate acyl radical from α-imino-oxy acids via selective C-C bond activation is reported. In the presence of silver catalyst, α-imino-oxy acids could undergo the decarboxylation, […]Yating Cao
- Correction: Computational methods for investigating organic radical species April 28, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB90053K, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tim Renningholtz, Ethan R. X. Lim, Michael J. James, Cristina TrujilloTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Tim Renningholtz
- Metal-free, Visible-Light-Mediated Phototransformations of ortho-Biaryl Appended Chalcones: Access to Oxathia[5]helicenes and 1,2,3,4-Tetrasubstituted Cyclobutanes. April 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00490J, PaperValerii Z. Shirinian, Alexey V. Zakharov, Eva E. Evsikova, Polina D. Grebennikova, Maria A. Krylova, Artem FakhrutdinovVisible-light-mediated metal-free irreversible phototransformations of ortho-bihetaryl appended chalcones are reported. Isosteric replacement of one of the aryl residues with a chalcone fragment in diarylethene (terarylene) molecules leads to a significant...The content of […]Valerii Z. Shirinian
- Synthesis of Dihydropyrimidinones via Urea-Based Multicomponent Reactions April 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00180C, Review ArticleAnirban Mandal, Prasanjit Ghosh, Sajal DasMulticomponent reactions (MCRs) have emerged as powerful tools in organic chemistry, enabling the rapid and efficient assembly of complex molecular architectures. Urea-based multicomponent reactions have gained significant attention due to...The content of this RSS Feed (c) The Royal Society of ChemistryAnirban Mandal
- Ene-Azide Chemistry in the Synthesis of 1,2,3-Triazoline/Triazole and Mechanistic Aspects April 28, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00236B, Review ArticleKunj Bihari MishraAlkenes and azides have been proven to be significant synthon in organic chemistry for the preparation of diverse medicinally valued nitrogen-containing heterocycles. The ene-azide cycloaddition reaction appears as an alternative...The content of this RSS Feed (c) The Royal Society of ChemistryKunj Bihari Mishra
- Bismuth(III)chloride catalyzed one-pot synthesis of thioenol ethers from 1,3-dicabonyls/2-oxindoles under ultrasonic irradiation April 27, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00250H, PaperBhoomikaben Panchal, Bhaveshkumar Panchal, Mrinal Talukdar, Anindita Bhar, Togati Naveen, Eeshwaraiah BegariBiCl3-catalyzed one-pot, three-component strategy has been developed for the construction of thioenol ethers from β-ketoesters or 1,3-diones or 2-oxindoles, N,N-dimethylformamide dimethylacetal, and thiols.To cite this article before page numbers are assigned, use the DOI form of citation […]Bhoomikaben Panchal
- Chemoselective Benzylic Csp3-H Bond Oxidation Reactions Catalyzed by AgII(bipy)2S2O8 Complex April 27, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D4OB02074J, PaperZaheen Akhter, Sumit Sharma, Radhika Anand, Muzamil Samad, Praveen Kumar Verma, Parvinder Pal SinghHere, we present a silver-catalyzed method for the selective oxidation of benzylic Csp³–H bonds with high chemo- and regioselectivity. This approach efficiently converts toluenes into aldehydes, methylenes into ketones, and...The content of this RSS Feed […]Zaheen Akhter
- Unconventional approaches for synthesis of 2-substituted benzothiazoles April 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00339C, Review ArticleFatemeh Doraghi, Mohammad Hadi Edareh, Mehdi Ghanbarlou, Bagher Larijani, Mohammad MahdaviBenzothiazoles are an important class of heterocycles for the synthesis of pharmaceuticals. This review describes many direct and green methods for the synthesis of 2-substituted benzothiazoles under transition metal catalysis or metal-free systems.To cite this article before […]Fatemeh Doraghi
- I2-DMSO-mediated [4 + 2] cyclization of methyl ketone with 2-aminobenzimidazole to construct 2,4-disubstituted benzo[4,5]imidazo[1,2-a] pyrimidines April 25, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00314H, PaperQian Guo, Mengyi Guo, Luoteng Cheng, Yifan Song, Wanqian Ma, Yibo Song, Suzhen Li, Xiaoqiong Deng, Xinxin Jia, Jianyong YuanA novel and efficient synthesis of 2,4-disubstituted benzo[4,5]imidazo[1,2-a]pyrimidine skeletons is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Qian Guo
- Regulation of a chromenylium fluorophore with a built-in recognition site for the detection of sulfite April 24, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00504C, PaperAnqi Hou, Yuanyuan Wu, Yumeng Liu, Chang Liu, Huirong Yao, Xianshun ZengA double charged cationic chromenylium analogue with a built-in pyridinium recognition site showed high sensitivity and selectivity for the detection of sulfite.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Anqi Hou
- Mechanism and stereoselectivity of a [3 + 2] cycloaddition involving a glucosyl nitrone: a MEDT study April 24, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00529A, PaperMohamed Chellegui, Simplice Koudjina, Ines Salhi, Sofiane Benmetir, Raad Nasrullah Salih, Haydar A. Mohammad-Salim, Guy Y. S. Atohoun, Jesus Vicente de Julián-OrtizThe [3 + 2] cycloaddition between C-(D-glucoso)-N-methyl nitrone and 1H-pyrrole-2,5-dione proceeds via an asynchronous one-step mechanism. The endo product shows strong 1CIN protease binding and promising drug-like […]Mohamed Chellegui
- Water-compatible electrogenerated chemiluminescence effect derived from readily accessible tripyridinium salts April 24, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00417A, PaperLewei Wang, Ru Zhang, Wenrong Cai, Junyao Li, Junming Chen, Datong WuA novel water-compatible ECL system composed of tripyridinium salts and potassium persulfate was developed, yielding emission at 478 nm.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Lewei Wang
- Enhanced Glucose Regulation Potential of C-peptide Mimics April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00318K, PaperAlpana Boruah, Nazim Uddin Afzal, Sayari Saha, Anusmrita Mazumdar, Dibyajyoti Ozah, Thaneswar Bora, Panchami Prabhakaran, Prasenjit Manna, Arup RoyThe Connecting peptide (C-peptide) once relegated as an epiphenomenon in insulin biosynthesis, has now been recognized for its capacity to instigate molecular effects along with important physiological functions. These findings...The […]Alpana Boruah
- A Formal [4+1] Annulation incorporating Styrylogous Aldol Condensation to Access Substituted 2-Styryl-benzofurans April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00348B, CommunicationMANYAM SUBBI REDDY, Kandivalasa Kamala, Surisetti SureshDespite the well-established aldol reaction and its vinylogous variants, the styrylogous version has been scarcely reported. Herein, we have introduced a styrylogous aldol condensation reaction. A novel base-mediated formal [4+1]...The content of this RSS Feed (c) The Royal Society of ChemistryMANYAM SUBBI REDDY
- Investigation of the factors influencing the selectivity and response times of glyoxal-selective probes April 24, 2025Org. Biomol. Chem., 2025, Advance ArticleDOI: 10.1039/D5OB00366K, PaperYuanyuan Wu, Chang Liu, Huirong Yao, Song He, Liancheng Zhao, Xianshun ZengFluorescent probes with different substituents on the amino group were designed to investigate their selectivity toward glyoxal and their applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Yuanyuan Wu
- Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions April 24, 2025Org. Biomol. Chem., 2025, Accepted ManuscriptDOI: 10.1039/D5OB00554J, CommunicationJinhui Cai, Chuanquan Chu, Yu Liu, Min Mao, Dahan Wang, Jinbing Liu, Huaixin Wei, Mingming YuA variety of 2,5-disubstituted 1,3,4-thiadiazoles is efficiently synthesized in 28-84% yields via three-component cyclization of 2-methylquinolines, arylhydrazides, and S powder under metal-free conditions which is successfully demonstrated here. This approach...The content of this […]Jinhui Cai
- Photocatalytic Three-component Reaction for Synthesis of Dithio-carbamates April 29, 2025
