RSC – Org. Chem. Front. latest articles- AgOTf-Promoted Transetherification of p-Methoxybenzyl Ethers with Allyl and Benzyl Bromides September 8, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00945F, Research ArticleYufan Yang, Dongyang Jiang, Xuan Li, Juxi Wang, Lu Gao, Wanshu Wang, Zhenlei SongConventional transetherification involves activation of the ether C-O bond, enabling either C-O/O-H bond metathesis with alcohols or C-O/C-O metathesis with other ethers. Here, we report an alternative approach based on...The content of this RSS […]Yufan Yang
- Electrochemical water activation for the oxidative cleavage of alkenes September 8, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00944H, Research ArticleNing Zhang, Hui Zhou, Guojuan Liang, Gaochen Liu, Xing Liu, Pengfei Zhou, Dong Zhang, Jing ZhouOxidative cleavage of alkenes allows rapid access to valuable products, starting from simple petrochemicals. Water is an ideal carrier of oxygen. Here, we report a novel electrochemical water activation for...The content of […]Ning Zhang
- Highly stereoselective synthesis of N-sulfonyl amidines with calcium carbide as an acetylene source September 8, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01010A, Research ArticleRui An, Weihao Cui, Peiming Gu, Meng-Xue WeiA practical and convenient approach for the highly stereoselective synthesis of N-sulfonyl amidines via a one-pot multi-component cascade reaction of sulfonyl azides, amines, water, and calcium carbide as an acetylene source has been developed.To cite this article before page numbers […]Rui An
- Electrophilic insertion and ring growth in 1,2,5-azadiborolidines: theoretical evidence for boron-driven expansion September 7, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01081K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Victor A. Lucas-Rosales, Miguel A. Vázquez, Gabriel Merino, Albert Poater, J. Oscar C. Jiménez-HallaDFT calculations predict endocyclic CO insertion in 1,2,5-azadiborolidines followed by dimerization and double [1,2]-migration, defining a fourth class of […]Victor A. Lucas-Rosales
- Facile N-directed Ru-catalyzed C(3)-H acylation of heterocyclopentadienes with acyl chlorides September 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00965K, Research ArticleKonstantin Shepelenko, Irina Gnatiuk, Andrey Aleksandrov, Mikhail Evgenevich Minyaev, Victor Chernyshev, Valentine P. AnanikovThe selective C3‒H functionalization of 2-substituted heterocyclopentadienes (furan, thiophene and pyrrole) remains challenging owing to the typically higher reactivity of the C5‒H and C4‒H bonds. In this study, we report...The content of this RSS […]Konstantin Shepelenko
- Site Selective Heck Arylation of N-Vinyl-7-Azaindole Engineered by N-Oxide Activation: Scope and Mechanistic Studies September 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00976F, Research ArticleSusanta Patra, Arunava Sengupta, Parthasarathi DasThe palladium-catalyzed site-selective arylation of N-vinyl-7-azaindole (AI) derivatives using (hetero)iodoarenes is reported. While N-vinyl-7-azaindole displays moderate regioselectivity, predominantly favoring α-arylation, N-oxide activation (AINO) induces a complete switch to exclusive β-arylation...The content of this RSS Feed (c) The Royal Society of ChemistrySusanta Patra
- Wavelength-tuned, photocatalytic chemoselective hydrodefluorination September 4, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01012H, Research ArticleMeng Guo, Zhi-Peng Ye, Yong-Qing Ye, Xiao-Qing Chen, Kai Chen, Hua YangA chemoselective hydrodefluorination of trifluoroacetamides enabled by switching the SET/EDA pathway through simply tuning the wavelength of irradiation, delivering the corresponding CFH2 and CF2H analogues selectively.To cite this article before page numbers are assigned, use the […]Meng Guo
- Streamlined synthesis of meta- or para-substituted triphenylamine[3]arenes and their hierarchical assembly into polyhedral cages September 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01089F, Research ArticleWangjian Fang, Xin Li, Audrey Nathania, Yimin Zhang, Guoqiang Jiang, Andrew C.-H. SueTriphenylamine[3]arenes (TPA[3]s) are a novel class of macrocyclic scaffolds with remarkable potential in supramolecular chemistry. In this study, we present a streamlined synthesis of TPA[3]s featuring meta or para-substituted bromophenyl...The content of this RSS Feed […]Wangjian Fang
- Contributors to the Organic Chemistry Frontiers Emerging Investigator Series 2024 September 3, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90065D, ProfileThis editorial showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator series.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
- Rh(III)-Catalyzed Cascade Cyclization of Enaminones with Diazo compounds: Switchable Syntheses of 2-Pyrones and Pyrido-quinazolinones September 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01086A, Research ArticleHongxiang Huang, Ruimeng Zhang, Leiqing Fu, Jie-Ping WanThe Rh-catalyzed C−H activation of N-pyridinyl enaminones and cascade cyclization with diazo compounds are reported to construct 2-pyrones and pyrido-quinazolinones with a broad range of substrates and good yields. The...The content of this RSS Feed (c) The Royal Society of […]Hongxiang Huang
- Recent Advances of Intermolecular Carbonyloxy Radicals Addition to Alkenes August 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01045D, Review ArticleJun Pan, Yuting Feng, Huijun Qian, Leiyang Lv, Zhiping LiOxygen-centered radicals are highly reactive intermediates that serve as key roles in radical-mediated organic transformations.Carbonyloxy radicals, a distinct subset of oxygen-centered radicals, not only exhibit the general reactivity patterns of...The content of this RSS Feed (c) The Royal […]Jun Pan
- Correction: One-pot ipso-hydroxylation and ortho-/para-halogenation of (hetero)arylboronic acids under tungsten catalysis August 28, 2025Org. Chem. Front., 2025, 12,5105-5105DOI: 10.1039/D5QO90069G, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zhilong Chen, Jiao KangThe content of this RSS Feed (c) The Royal Society of ChemistryZhilong Chen
- Recent advances in C(sp3)–H functionalization via molecular electrocatalysis August 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01036E, Review ArticleXiao-Li Lai, Ying-Kai Lai, Peng Xiong, Hai-Chao XuMolecular electrocatalysis provides a sustainable platform for C(sp3)–H activation by enabling catalyst-controlled electron transfer or atom transfer under mild conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Xiao-Li Lai
- Photocatalyzed defluorinative allylsulfonylation of alkynes to access gem-difluorinated sulfonyl-1,4-dienes August 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01008J, Research ArticleMeng-Dan Wang, Hua-Hua Wang, Lin-Xi Xiao, Xing-Guo Zhang, Hai-Yong TuA photocatalyzed three-component gem-difluoroallylsulfonylation of alkynes with trifluoromethyl alkenes and sodium sulfinates via selective C–F bond activation has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Meng-Dan Wang
- Structurally divergent reactivity of 2,2-disubstituted azetidines – mechanistic insights and stereochemical implications of amide coupling and ring expansion to 5,6-dihydro-4H-1,3-oxazines August 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00804B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aditya K. Sahay, Callum S. Begg, Xiurong Zhang, James. A. Bull, Alan C. SpiveySubjecting 2,2-disubstituted azetidines to amide coupling with carboxylic acids is found to effect either N-acylation or ring expansion to […]Aditya K. Sahay
- Core modified N-confused pentaphyrin variants with adaptive (anti)aromaticity August 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01088H, Research ArticleHarapriya Rath, Manik Jana, Gunasekaran Velmurugan, Sumit Sahoo, Peter CombaRetrosynthetically designed and syntheses of three unprecedented core modified N-confused pentaphyrins(sapphyrin) possessing E-ethylene bithiophene moiety with tunable Hückel (anti)aromaticity is reported. The solution-state spectroscopic analyses reveal the sustained E-conformation for...The content of this RSS Feed (c) The Royal […]Harapriya Rath
- Clean and Economic Synthesis of N-sulfonyl Isothioureas from Isocyanides, Sulfonamides and Disulfides August 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00867K, Research ArticleChangping Xun, Zhibin Nong, Kun Hu, Wenfeng Lv, Jiajun Zhao, Ziqiong Yin, Jialu Lv, Feng Jiang, Qing-Wen GuiAn electrochemical three-component reaction involving isocyanides, sulfonamides and disulfides was developed, using nBu4NI as a redox catalyst and electrolyte. A rare of N-to-N [1,3]-H shift was observed in this transformation....The […]Changping Xun
- Harnessing the synergistic power of light and electricity: an emerging frontier in catalytic heterocycle synthesis August 26, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01097G, HighlightYanchen Chen, Binbin HuangThe strategic integration of photochemistry and electrochemistry in organic synthesis has opened new avenues for catalytic heterocycle synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryYanchen Chen
- Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls August 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00816F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lucía Sánchez-Jiménez, Adrián Gargantiel, Manuel A. Fernández-Rodríguez, Patricia García-GarcíaDivergent gold-catalyzed cycloisomerizations of o-cyclopropylidenemethyl-o′-alkynylbiaryls give access to two distinct polycyclic scaffolds containing a tricyclic bridgehead carbon center, with selectivity controlled by temperature.To cite […]Lucía Sánchez-Jiménez
- Pd-catalyzed hydroesterification of vinyl cyclopropanes with aryl formates August 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00634A, Research ArticleJunhua Li, Chunyin Li, Jing Li, Zhanwei Wang, Fengyin Wang, Yian ShiVinyl cyclopropanes can be efficiently hydroesterified with Pd(OAc)2-Xantphos as a catalyst and aryl formates as a carbonyl source under mild reaction conditions, providing a wide variety of carboxylic esters in up to 86% yield.To cite this […]Junhua Li
- AgOTf-Promoted Transetherification of p-Methoxybenzyl Ethers with Allyl and Benzyl Bromides September 8, 2025
