RSC – Org. Chem. Front. latest articles- Anion/ion pair binding and chiral modulation investigation based on an 18-crown-6-functionalized Schiff base macrocyclic receptor March 21, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00203J, Research ArticleChanni Cheng, Shoucheng Sun, Dezhi Zhao, Chengyou Han, Feng WangTwo π-conjugated fluorescent macrocyclic receptors (MR and C-MR, with C-MR bearing two 18-crown-6 moieties) were successfully synthesized. MR exhibits efficient anion recognition via stable complexes formed by multiple C(sp²)-H•••X⁻ hydrogen...The content of this RSS Feed (c) The Royal […]Channi Cheng
- Deciphering Light-Triggered Mg2+-Assisted FeCl3 Ion-Pairing: An Efficient Photo-Oxidant for Chemo-Divergent Functionalization of 3-Arylidene Indoline March 21, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01738F, Research ArticleUmasish Jana, Gopal Rana, Maynak Pal, Abhishek Kar, Rajkamal SahooIron-based photocatalysis has emerged as an appealing “green alternative” to precious-metal photocatalysts that rely on ligand-to-metal charge-transfer (LMCT) activation, facilitating advanced organic transformations. Here, we investigate Mg2+-assisted photocatalytic behaviour of...The content of this RSS Feed (c) The Royal […]Umasish Jana
- Hydrogen Atom Transfer Enabled Acylsugars Synthesis via a Cooperative Copper and NHC Catalysis March 21, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00128A, Research ArticleYuqiong Tan, Yu Xiang, Yang YeIn this study, we report a direct acylation method for saccharides, achieved through the combination of copper and N-heterocyclic carbene (NHC) catalysis. This modular Cu/NHC dual-catalysis system exhibits excellent tolerance...The content of this RSS Feed (c) The Royal Society of ChemistryYuqiong Tan
- Mono-meso-free N-confused Hexaphyrin with Tunable NIR Absorption: Synthesis, Coordination, and Oxidative Dimerization March 20, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00221H, Research ArticleLingfang Zhang, Zhengpeng Huang, Qizhao Li, Glib Baryshnikov, Bin Zhu, Mingbo Zhou, Chengjie Li, Hans Ågren, Shijun Li, Jianxin Song, Yongshu XieA weakly Möbius aromatic mono-meso-free N-confused hexaphyrin 1 was synthesized and oxidized into a Cmeso-Cmeso linked dimer (1)2. Interestingly, metallation of 1 with Cu(II) in MeCN/MeOH […]Lingfang Zhang
- Visible-light-driven dehalogenative oximation of alkyl halides March 20, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00020G, Research ArticleFeng Xu, Dayong Shi, Ruihua LiuA visible-light-driven, transition-metal-free dehalogenative oximation of simple alkyl halides has been developed, exploiting a boryl radical-mediated halogen atom transfer (XAT) process. This strategy efficiently converts readily available alkyl halides into...The content of this RSS Feed (c) The Royal Society of ChemistryFeng Xu
- Stereoselective synthesis of β-sulfonyl and β-phosphonyl (E)-fluoroalkenes via visible-light-induced multicomponent defluorinative coupling March 20, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00208K, Research ArticleLiping Wu, Kangjie Fan, Jiamei Ni, Jialuo Ying, Chaojie Wang, Zhiwei ChenHerein, we report a photocatalytic three-component radical coupling that enables the dual functionalization of alkenes with monofluoroalkenyl and sulfonyl/phosphonyl groups. This strategy offers a streamlined access to (E)-β-fluoroalkenyl sulfones and...The content of this RSS Feed (c) […]Liping Wu
- mer-Ir(pmp)3 as a strongly photoreducing and stable Ir(C^C)3 photocatalyst for metallaphotoredox catalysis March 19, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00086J, Research ArticleMáire Griffin, Eli Zysman-ColmanHere we report a new homoleptic Ir(NHC) photocatalyst, mer-Ir(pmp)3 which is the first Ir(C^C)3 photocatalyst to operate effectively using excitation sources peaking in the visible (λexc = 427, 440 and...The content of this RSS Feed (c) The Royal Society of ChemistryMáire Griffin
- Access to 3-Amino-carbazoles from CF3-3-Indolylmethanols via Sc(OTf)3-Catalyzed C2-Defluorinative Allylation and DBN-Promoted Dedluorinative Annulation March 19, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00163G, Research ArticleQing Liu, Xin Liu, Weidong RaoA novel method for constructing 3-(2-allyl)-indolyl substituted gem-difluoroalkenes that relies on Sc(OTf)3-catalyzed C2selective allylation/defluorination cascade of trifluoromethylated 3-indolylmethanols has been realized. This diazo-free protocol features exclusive regioselectivity and broad substrate...The content of this RSS Feed (c) The Royal Society of ChemistryQing Liu
- Visible-Light-Driven C-H Functionalization of Double Bonds with Diazo Compounds under Mild Reaction Conditions March 19, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01537E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Miguel Angel Valle-Amores, Benedetta Carli, Ian MacLean, Lara Martínez-Fernández, Raúl Pérez-Ruiz, Leyre Marzo, Alberto Fraile, Jose AlemanExpanding the toolbox of C-H functionalization reactions applicable to the late-stage modification of complex molecules of […]Miguel Angel Valle-Amores
- Regiodivergent N1-and C3-Carboxylation of Indoles March 18, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00306K, Research ArticleXia Liu, Zhi Li, Congman Song, Guiqing Xu, Duanyang KongRegioselective carboxylation of indoles using CO₂ remains a longstanding challenge, particularly for achieving controllable access to both N1-and C3-carboxylated products under unified conditions. Herein, we report a temperature-controlled, regiodivergent strategy...The content of this RSS Feed (c) The Royal […]Xia Liu
- Synthesis of chiral rotaxanes: Controlling the molecular chirality of bis-catechol spiroborate through threading March 18, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D5QO01744K, Research ArticleKion Takada, Rin Usui, Takumi Takizawa, Masaya Naito, Yusuke Okada, Nagao Kobayashi, Shinobu Miyagawa, Yuji TokunagaThe investigation of molecular chirality within interlocked molecules is an appealing research area however, the synthesis of optically active interlocked molecules poses considerable challenges. In this study, we combined chiral...The content of […]Kion Takada
- Comment on “Dithiocarbamate-mediated thioamidation of arylglyoxylic acids by decarboxylative–decarbonylative C–C bond formation reactions” by D. Patra and A. Saha, Org. Chem. Front., 2023, 10, 1686 March 17, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D4QO00393D, Comment Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xavier CrearyThe purported reaction occurs only in trace amounts (5% yield). 13C labelling and computational studies show that the suggested mechanism is incorrect.To cite this article before page numbers are assigned, use the […]Xavier Creary
- Reply to the ‘Comment on “Dithiocarbamate-mediated thioamidation of arylglyoxylic acids by decarboxylative–decarbonylative C–C bond formation reactions”’ by X. Creary, Org. Chem. Front., 2026, 13, DOI: 10.1039/D4QO00393D March 17, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D4QO01258E, CommentDebabrata Patra, Amit SahaThe thioamidation protocol of arylglyoxylic acids has been reproduced satisfactorily by our research group as well as by another research group from a different institute.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]Debabrata Patra
- Expression of concern: Dithiocarbamate-mediated thioamidation of arylglyoxylic acids by decarboxylative–decarbonylative C–C bond formation reactions March 17, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO90015A, Expression of Concern Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Debabrata Patra, Amit SahaTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of ChemistryDebabrata Patra
- Organocatalytic approach to vinylic nucleophilic substitution at electrophilic alkenes March 17, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00037A, Research ArticleMatvey K. Ilyushchenko, Rinat Faritovich Salikov, Yury TomilovNucleophilic catalysis is a powerful and well-developed tool for activating and manipulating carbon-centered electrophiles. However, its application to substitution at sp²-carbon atoms has been explored only for acylation reactions and,...The content of this RSS Feed (c) The Royal Society of […]Matvey K. Ilyushchenko
- Synthesis of α-C-Glycoside Conjugates via Giese-like Reaction Triggered by Photoactivated Electron Donor–Acceptor (EDA) Complexes and in situ photocatalytic species March 17, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00174B, Research ArticleFrancesco Riina, Giulio Chiarello, Lorenzo Poletti, Daniele Ragno, Carmela De Risi, Mirco Natali, Federico Droghetti, Alessandro Massi, Graziano Di CarmineTwo visible-light-mediated, catalyst-free strategies for the synthesis of α-C-glycoside conjugates are reported. The methods exploit electron donor–acceptor (EDA) complex activation and in situ generated photocatalytically active species to […]Francesco Riina
- Tuning Donor Ability of Oxygen with Inverse α-Effect: Two Levels of Kinetic Control Open Access to Four Classes of Peroxygenated Heterocycles March 16, 2026Org. Chem. Front., 2026, Accepted ManuscriptDOI: 10.1039/D6QO00028B, Research ArticleKsenia V Skokova, Yulia Yu. Belyakova, Peter S. Radulov, Dmitri I Fomenkov, Igor Krylov, Ivan A. Yaremenko, Igor Alabugin, Alexander Olegovich Terent'evTunable acid-catalyzed reaction with hydrogen peroxide open access to diverse oxygen-rich cyclic peroxides from common 1,4-diketone precursors. Precise kinetic control via acid and hydrogen peroxide loadings […]Ksenia V Skokova
- Design principles for enantiospecific para- and ortho-[3,3] rearrangements of chiral aryl–allyl ethers March 13, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00040A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Johanna Breinsperger, Maximilian Kaiser, Peter GärtnerRegioselective allyl–aryl rearrangements directed by substituents yield chiral ortho- and para-alkylated products in high enantiomeric purity.To cite this article before page numbers are assigned, use the DOI […]Johanna Breinsperger
- Silver-catalyzed regioselective direct dichlorotrifluoromethoxylation of terminal alkynes March 13, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00025H, Research ArticleMuhammad Bilal Altaf, Qingyun Huang, Pingping TangA method for silver-catalyzed dichlorotrifluoromethoxylation of terminal alkynes has been reported. This reaction demonstrates broad substrate tolerance, accommodating various functional groups, and late-stage modifications of complex molecules.To cite this article before page numbers are assigned, use the DOI form of citation […]Muhammad Bilal Altaf
- Theoretical insight into the mechanism, selectivity, and substituent effects in Rh-catalyzed asymmetric arylation of cyclobutenone ketals with arylboronic acids March 12, 2026Org. Chem. Front., 2026, Advance ArticleDOI: 10.1039/D6QO00087H, Research ArticleJinzhao Wang, Qiang Zhang, Li Jiang, Rongxiu Zhu, Dongju ZhangDFT calculations elucidate the mechanism and origins of regio- and enantioselectivity in rhodium-catalyzed asymmetric arylation of cyclobutenone ketals and reveal that electronic substituent effects of arylboronic acids control product selectivity.To cite this article before page numbers are assigned, […]Jinzhao Wang
- Anion/ion pair binding and chiral modulation investigation based on an 18-crown-6-functionalized Schiff base macrocyclic receptor March 21, 2026
