RSC – Org. Chem. Front. latest articles- 1,2,3-Trifunctionalization of α,α-Disubstituted Vinyl Aldehydes Enabled by Radical 1,2-Migration of Formyl May 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00461F, Research ArticleXiong Yang, Jinmin Luo, Ji Li, Yao Yuan, Gangguo ZhuAs compared to the well-established 1,2-difunctionalizations, the 1,2,3-trifunctionalization of alkenes has been much less developed, due to the formidable challenges in controlling site-, regio- and diastereoselectivity. Enabled by an uncommon...The content of this RSS Feed (c) The Royal […]Xiong Yang
- Dynamic supramolecular nanosheet structures formed by aromatic amphiphiles and their functions May 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00561B, Review ArticleYanqiu Wang, Myongsoo LeeThis review describes the recent progress in the development of nanosheet structures through the self-assembly of π-conjugated aromatic amphiphiles. We expect our research progress will provide a new strategy for broadening the application areas of self-assembled 2D nanosheet structures.To cite this article before page […]Yanqiu Wang
- Cobalt-Catalyzed Enantioselective Radical Hydroamination of Alkenes with N-Fluorobenzenesulfonimides: Theoretical Insight of Enantio-Determining SN2-like Reductive Elimination May 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00696A, Research ArticleYujie Liang, Bo Zhu, Yabin Jiang, Wei GuanThe cobalt-catalyzed enantioselective radical hydroamination of alkenes with N-fluorobenzenesulfonimides has been systematically investigated using density functional theory (DFT) calculations. The favorable reaction mechanism consists of six key processes: halogen atom...The content of this RSS Feed (c) The Royal Society of […]Yujie Liang
- Azlactone Rings: Uniting Tradition and Innovation in Synthesis May 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00657K, Review ArticleMarcelo H. R. Carvalho, Geovana F. Vargas, João P. R. S. Ribeiro, Pedro P. de Castro, Giovanni Wilson AmaranteAzlactones, also known as oxazolones, are a class of heterocyclic compounds with significant relevance in the synthesis of non-natural amino acids and their derivatives. Their reactivity stems from the […]Marcelo H. R. Carvalho
- A photocatalytic electron-rich acceptor-involved EDA complexes for Markovnikov addition of alkynes with N-sulfonyl-azoles May 26, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00544B, Research ArticleJinhua Liu, Tang Xiao, Weixiong Chen, Zongjing Hu, Yun Zhao, Shunying LiuA Markovnikov addition reaction to synthesize α-sulfonyl-β-triazole olefins mediated by photocatalysis via a ternary EDA complex intermediate has been reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Jinhua Liu
- Access to (E)-δ-Vinyl-Homoallylic Alcohols/Ethers/Pyrazoles by Ring-opening Nucleophilic Substitution of cyclopropyl allylic alcohols May 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00678C, Research ArticleYulu Zhang, Ying Shao, Jiangtao Sun, Shengbiao TangA highly efficient Lewis acid-catalyzed ring-opening nucleophilic substitution of cyclopropyl allylic alcohols has been developed. The use of pyrazoles as nucleophiles, under catalysis with Yb(OTf)3, a series of (E)-δ-vinyl-homoallylic pyrazoles...The content of this RSS Feed (c) The Royal Society of […]Yulu Zhang
- Chelation-controlled stereospecific ring-opening arylation of α-aminoaryl-tethered alkylidenecyclopropanes: stereoselective synthesis of polysubstituted conjugated dienes May 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00496A, Research ArticleMiao-Miao Ji, Ying Tang, Wen-Mei Luo, Yong-Yu He, Ai-Jun Ma, Jin-Bao PengA palladium-catalyzed stereospecific ring-opening arylation of α-aminoaryl-tethered alkylidenecyclopropanes for the stereoselective synthesis of 1,1,2-trisubstituted conjugated dienes has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Miao-Miao Ji
- Photoinduced β-fragmentation for efficient pyridine alkylation via N-alkoxypyridinium salts May 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00400D, Research ArticleHeng Liu, Fangrui Wu, Zhidong Wan, Changhai Yue, Changsheng Wang, Chengkou Liu, Yuguang Li, Zheng Fang, Hong Qin, Zhao YangWe established a mild and atom-economical photocatalytic strategy for direct pyridine alkylation via β-fragmentation of N-alkoxypyridinium salts, serving dually as alkyl radical precursors and pyridine sources.To cite this […]Heng Liu
- Recent progress in selective functionalization of diols via organocatalysis May 22, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00645G, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liaba Niaz, Sojeong Bang, Jeonghyo LeeThis work provides a comprehensive overview of recent advances in the selective transformation of diols, focusing on diverse organocatalytic strategies and the mechanistic principles underlying selectivity control.To […]Liaba Niaz
- BF3-enabled unusual (3 + 2) cycloaddition of bicyclobutanes with aldimine ester: access to 2-azabicyclo[2.1.1]hexanes May 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00579E, Research ArticleQin Jiang, Jianyang Dong, Dejiang Yu, Fang Lei, Ting Li, Tengfei Kang, Juan Fan, Huaming Sun, Dong XueWe disclose a method for BF3-enabled, unusual (3 + 2) cycloaddition between BCBs and aldimine esters, providing access to previously elusive 2-aza-BCH derivatives.To cite this article before page numbers are […]Qin Jiang
- A formal vinylogous Schmidt reaction: nitrogen insertion of para-quinone methides May 19, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00476D, Research ArticleBo Wang, Chen Zhu, Yanhao Dong, Chen Kong, Hanxiao Zhu, Tiandi Ding, Guoyue Wei, Yatong Yang, Xin Zhao, Magnus Rueping, Qingqiang Yao, Kun Zhao, Yan Li, Ying ZhiWe report a facile introduction of a nitrogen-containing group into p-QM substrates, which delivering the benzoxazolidine motif through a formal […]Bo Wang
- Palladium-catalyzed intramolecular redox-relay Heck cyclization: access to heterocycles bearing all-carbon quaternary centers May 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00431D, Research ArticleLinjun Qi, Rongjing He, Xiaofeng Tong, Shuling YuWhile the intramolecular Heck reaction of aryl/vinyl halides with various alkenes has been well studied, the exploration of acyclic alkenol systems via a redox-relay strategy remains unexploited.To cite this article before page numbers are assigned, use the DOI form of […]Linjun Qi
- 2-Pyridone-enabled manganese-catalyzed ortho-selective deuteration of aromatic amides with D2O May 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00606F, Research ArticleTao Qian, Zhi-Jiang Jiang, Jinfeng Zheng, Jia Chen, Zhanghua Gao, Jian-Fei BaiA manganese-catalyzed protocol for the ortho-selective deuteration of aromatic amides has been developed, featuring Mn(CO)5Br as the catalyst, 2-pyridone-assisted C–H activation, and D2O as the deuterium source.To cite this article before page numbers are assigned, use […]Tao Qian
- α-Sulfonylated ketazine synthesis from vinyl azides and sodium sulfinates using CAN: radical C–S/N–N coupling cascade as a key reaction pathway May 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00508F, Research ArticleMikhail M. Doronin, Alexander S. Klikushin, Olga M. Mulina, Michael G. Medvedev, Vera A. Vil’, Liang-Nian He, Alexander O. Terent'evSynthesis of α-sulfonylated ketazines from vinyl azides and sodium sulfinates proceeding via radical C–S/N–N coupling cascade has been developed.To cite this article before page numbers are assigned, use […]Mikhail M. Doronin
- Selective separation of meta- and para-cresol using nonporous adaptive crystals of perpropoxylated pillar[5]arene May 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00620A, Research ArticleHongyan Zhang, Ming Li, Li Shao, Haozhong Liang, Bin Hua, Niveen M. Khashab, Feihe HuangHerein we report an efficient strategy for the separation of meta-cresol and para-cresol based on nonporous adaptive crystals of perpropoxylated pillar[5]arene.To cite this article before page numbers are assigned, use the DOI form […]Hongyan Zhang
- Pyrrolyl-radical-based di-/tri-functionalization of alkenes using sulfonyl pyrroles via radical/radical cross-coupling May 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00557D, Research ArticleJia-Xuan Luo, Ze Zhuang, Yu-Zhang Huang, Xiaohui Kang, Yong LuoSynthesis of dipyrrolyl acetonitriles and benzhydryl pyrroles by multi-functionalization of alkenes with sulfonyl pyrroles was developed under visible-light irradiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Jia-Xuan Luo
- Modular access to functionalized azetidines via electrophilic azetidinylation May 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00552C, Research ArticleDayu Tian, Guang Chen, Xian Xiao, Xiaocheng Wang, Hai-Jun ZhangElectrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Dayu Tian
- Cascade cyclization/fluoromethylthiolation of alkynes, unsaturated α-bromocarbonyls and PhSO2SRF May 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00585J, Research ArticleCui Zhang, Yun-Tao Shen, Ning-Xin Xia, Xin-Song Zhou, Li-Bo Yang, Jia Hu, Ya-Min LiA copper-catalyzed cyclization/fluoromethylthiolation cascade of alkynes, unsaturated α-bromocarbonyls and PhSO2SCF2H/PhSO2SCF3 has been developed to access fluoromethylthiolated cyclopentenes and cyclohexenes.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Cui Zhang
- Active electropositive α-chlorine: trichloroacetonitrile as an electrophilic chlorination reagent May 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00379B, Research ArticleBingxing Zhou, Lei Bai, Changming XuAn inverse-electron C–Cl bond cleavage of Cl3CCN under basic conditions to give the chlorine cation, which was used as an unprecedented active electrophilic chlorine source for α-mono- and α-dichlorination of carbonyl compounds.To cite this article before page numbers are assigned, use the […]Bingxing Zhou
- Brønsted acid enabled metal-free remote oxygenation and amidation of unstrained C–C bonds via 1,4-heteroaryl migration chaperoned radical-polar crossover May 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00549C, Research ArticleXiaofei Xie, Yun Shi, Yukun Li, Jinge Gui, Yingguang Zhu, Kang ChenA Brønsted acid enabled metal-free remote functionalization of NHPI esters via 1,4-group migration chaperoned radical-polar crossover has been established, affording a variety of alcohols, ethers and amides in moderate to good yields.To cite this article before […]Xiaofei Xie
- 1,2,3-Trifunctionalization of α,α-Disubstituted Vinyl Aldehydes Enabled by Radical 1,2-Migration of Formyl May 27, 2025
