RSC – Org. Chem. Front. latest articles- Asymmetric [4+3] Cycloaddition of Hydroxyphenyl Indolinones to Synthesize Novel Spirooxindoles February 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00075K, Research ArticleShuhui Huang, Yongquan Xu, Mohan Li, Lihuan Liao, Weiwu RenThe first asymmetric [4+3] cycloaddition of hydroxyphenyl indolinones has been reported to afford a new series of multisubstituted spirooxindole derivatives embedded with an oxadiazepine scaffold with high stereoselectivities. The reaction...The content of this RSS Feed (c) The Royal […]Shuhui Huang
- Synthesis of Pyrrole Derivatives via Ordered Isocyanide Insertion Reaction Driven by Ring Strain Mediated by Non-covalent Bond Interactions February 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02144D, Research ArticleShan-Shan Liu, Jiang-Nan Zheng, Zhi-Wen Zhao, Yi Zhang, Ping He, Yong-Jie Wu, Jiang-Tao Feng, Long Wang, Zhi-Lin RenAn efficient synthesis of pyrrole derivatives is achieved via ordered isocyanide insertion reaction, driven by ring strain and mediated by intramolecular non-covalent bonds. This method harnesses the strategic design of...The […]Shan-Shan Liu
- Chiral Phosphoric Acid Catalyzed Intermolecular [4+2] Cycloaddition for Chiral Azomethine Imines: Mechanism and Stereochemical Model February 21, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00203F, Research ArticleWeichi Chen, Zhongqing Qu, Shuanglin Qu, Abing DuanAzomethine imines are an outstanding class of 1,3-dipolar species that are important synthetic building blocks for di-nitrogenated heterocycles. Despite their significance, the current synthesis of chiral azomethine imines relies on...The content of this RSS Feed (c) The Royal Society of […]Weichi Chen
- Organocatalytic Asymmetric Desymmetrization of Cyclopentene-1,3-diones via Formal Diaza-ene Reaction with Donor–Acceptor Hydrazones February 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00081E, Research ArticleSubhankar Biswas, Subhas Chandra PanHerein we disclose a catalytic asymmetric desymmetrization of cyclopentene-1,3-diones via formal diaza-ene reaction/tautomerization with donor-acceptor hydrazones. H8-TRIP catalyst was found to be effective for this reaction. The chiral cyclopentane 1,3-diones...The content of this RSS Feed (c) The Royal Society of ChemistrySubhankar Biswas
- In situ generated cobalt(I) catalyst for the efficient synthesis of novel pyridines: Revisiting the mechanism of [2+2+2] cycloadditions February 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00222B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Susana García-Abellán, Asier Urriolabeitia, Victor Polo, Manuel IglesiasThe [2+2+2] cycloaddition of alkynes and nitriles is an efficient and atom-economic method for the synthesis of pyridines. However, most of the examples so far […]Susana García-Abellán
- Cycloisomerization of 7-En-2-yn-1-ones to Bicyclo[3.1.0]hexanes Using Electrophilic Fluorination or Chlorination Agents February 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02373K, Research ArticleYuki Yasuda, Daisuke Sato, Akira Tsubouchi, Akio SaitoIn contrast to the π-electrophilic transition metal-catalyzed cycloisomerization of enynes, systematic studies on the reaction of enynes by activation of carbonyl groups conjugated to alkynes are lacking. Herein, we report...The content of this RSS Feed (c) The Royal Society of […]Yuki Yasuda
- Deoxygenative ortho-Benzylation of Aryl Iodides with Benzyl Alcohol via Palladium/Norbornene Cooperative Catalysis February 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00094G, Research ArticleShaowen Ling, Shuaichen Zheng, Baolong Xu, Hui Liu, Xinjin Li, Feng-Gang SunHerein, we demonstrate a robust palladium/norbornene-catalyzed deoxygenative ortho-benzylation of aryl iodides with non-derivatized benzyl alcohol, enabling assembly of various diarylmethanes with high efficiency. Assisted by carbodiimides, alcohol was transiently converted...The content of this RSS Feed (c) […]Shaowen Ling
- Biocatalytic atroposelective synthesis of heterobiaryls and heterobiaryl N-oxides via dynamic kinetic resolution February 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00011D, Research ArticleXinyue Hao, Bin Wang, Zhuangfei Tian, Zhouchang Yao, Tianzhang Qiao, Ling Huang, Haigen FuHeterobiaryl and heterobiaryl N-oxide atropisomers are important scaffolds in various chiral ligands, organocatalysts, and bioactive molecules. Here, we report a highly efficient biocatalytic route for the asymmetric synthesis of axially...The content of this RSS […]Xinyue Hao
- A Protodefluorinated Selectfluor® Heteroaggregate Photoinduces Direct C(sp3)−H Fluorinations Without Photocatalyst February 19, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00149H, Research ArticleShahboz Yakubov, Joshua Philip BarhamHerein, we uncover a hitherto hidden role of H-TEDA(BF4)2 – a cheap, stable, recoverable by-product of radical C(sp3)–H fluorinations using Selectfluor®. This forms a photoactive, mixed heteroaggregate with Selectfluor® which...The content of this RSS Feed (c) The Royal Society of ChemistryShahboz Yakubov
- Zn-promoted Sandmeyer-type reductive chalcogenation of (hetero)aryl diazonium salts February 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00103J, Research ArticleQiujin Fan, Yanchuang Zhao, Junhong Wang, Ying Bai, Shengbin Zhou, Xinxin ShaoIn this report, we describe a nickel-free, zinc-induced reductive coupling between (hetero)aryl diazonium salts and electrophilic chalcogen species under mild reaction conditions.To cite this article before page numbers are assigned, use the DOI form of citation […]Qiujin Fan
- Core-Extended Nonastarazines Featuring Diverse Arm Configurations via One-Pot Sequential Reactions February 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02403F, Research ArticleHonglin Qiu, Jiadong Zhou, Yi Feng, Linlin Liu, Zengqi XieThis article presents the successful synthesis of a novel series of core-extended quasi-planar nonastarazine (NSA) derivatives, featuring diverse arm configurations, through one-pot sequential reactions. Analysis of their single-crystal structures reveals...The content of this RSS Feed (c) The Royal […]Honglin Qiu
- Mechanophoric hydrogels: when mechanical stress produces useful responses February 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02060J, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Franciela Arenhart Soares, Pol BeseniusMechanophoric hydrogels undergo visible color changes or alterations in optical properties in response to mechanical stimuli. Achieving mechanophoric features in hydrogel materials involves careful control of the polymer […]Franciela Arenhart Soares
- Photoredox-Catalyzed Generation of α-Carbonyl Carbocations: General Access to α-Tertiary Amino Acid Derivatives February 18, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02306D, Research ArticleYa-Zhen Zeng, Wang Zhang, Man-Yi Han, Peng Wang, Hanmin Huangα-Carbonyl carbocations, serving as the umpolung forms of the synthetically fundamental α-carbonyl carbanions, are highly reactive species. The controlled generation and subsequent strategic employment of these reactive intermediates remain challenging....The content of this RSS Feed (c) The Royal […]Ya-Zhen Zeng
- 5-Methylated polyprenylated acylphloroglucinol derivatives as low-voltage-gated Ca2+ channel inhibitors February 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02233E, Research ArticleYa-Li Hu, Ding Dong, Jian-Jun Zhao, Kun Hu, Ling-Mei Kong, Yun-Xia Hu, Xing-Ren Li, Song-Yu Li, Yin Nian, Gang XuTwenty-seven PPAPs (1–27), all decorated with a methyl group at C-5, were identified from Hypericum ascyron L. Compounds 1–3 are characterized by an unusual cyclopentane framework. Several compounds […]Ya-Li Hu
- Recent advances in the synthesis of nitrogen heterocycles via Rh(III)-catalyzed chelation-assisted C-H activation/annulation with diazo compounds February 17, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00111K, Review ArticleJidan Liu, Ruilian Liang, Qinglian Yan, Liyao Zheng, Zhao-Qing Liu, Shouzhi PuDiazo compounds are a class of readily available and versatile reagents in modern organic synthesis that have been used as valuable synthetic building blocks for a diverse range of important...The content of this RSS Feed (c) […]Jidan Liu
- Dual-state emission of pyrazolyl-pyrrolo[3,4-b]pyridin-5-ones via excited-state intramolecular proton transfer (ESIPT): multicomponent synthesis and optical characterization February 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02256D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Julio C. Flores-Reyes, Yoarhy A. Amador-Sánchez, Alejandro Valderrama-Celestino, Bertha D. Barrios-Campos, Ricardo A. Peralta, Michael T. Huxley, Ilich A. Ibarra, Alejandro Islas-Jácome, Diego Solis-Ibarra, Eduardo González-ZamoraThe dual-state emission (DSE) phenomenon allows DSEgens […]Julio C. Flores-Reyes
- Enantioselective modular synthesis of α-aryl-α-heteroaryl aminonitriles with parts per million organocatalyst loading: mechanistic investigation for stereochemical origins February 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02362E, Research ArticleYusuke Oyamada, Kaito Ishikawa, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi NakamuraAn enantioselective Friedel-Crafts reaction of iminonitriles gave chiral α-aryl-α-heteroarylaminonitriles in high yield with good enantioselectivity. Pyrrole and indole additions produced different stereochemistries under the same chiral catalyst, explained by DFT.To cite this article before page numbers are assigned, […]Yusuke Oyamada
- Dissipative formation of a transient foldaxane with a fuel-like thread February 15, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02092H, Research ArticleCheng Feng, Shouzhe Zhu, Shuang Yang, Feifei Xing, Xiang WangA transient antiparallel foldaxane forms with a thread molecule, which, in the presence of a base, dissipates to a mixture of antiparallel/parallel double helixes and a parallel foldaxane.To cite this article before page numbers are assigned, use the […]Cheng Feng
- Photoredox β-C(sp3)-H Heteroarylation of o-Iodoaryl-alkan-1-ones with Heteroarenes via HAT and Dual C-H Functionalizations February 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00147A, Research ArticleGuang-Chuan Xu, Liang Zeng, Ming Hu, Fujin Sun, Jin-Heng LiA synthetically useful method for the formal β-heteroarylation of ketones via an iodoarene-directed photoredox remote C(sp3)−H heteroarylation of o-iodoarylalkan-1-ones with heteroarenes is reported. This protocol relies on single electron transfer...The content of this RSS Feed (c) The Royal […]Guang-Chuan Xu
- Organic Chemistry Frontiers Outstanding Paper Awards 2014–2023 February 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90009C, EditorialAn introduction to the award-winning papers and authors of our Outstanding Paper Awards 2014–2023.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
- Asymmetric [4+3] Cycloaddition of Hydroxyphenyl Indolinones to Synthesize Novel Spirooxindoles February 21, 2025
