RSC – Org. Chem. Front. latest articles- Palladium-catalysed asymmetric regioselective hydroamination of dienoates March 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00402K, Research ArticleBao-Xin Liu, Xin-Ting Qin, Shi-Cun Li, Lei Zhu, Qin Ouyang, Wei Du, Ying-Chun ChenElectron-deficient dienoates are occasionally utilised in hydrofunctionalisation reaction, and regioselectivity is a common concern. Here we report the palladium-catalysed enantioselective formal 1,4-Michael addition of pyrazoles to δ-aryl-substituted dienoates, proceeding in...The content of this RSS […]Bao-Xin Liu
- Copper-Mediated Divergent Synthesis of Halogenated 1-Pyrrolines, 3-Azabicyclo[3.1.0]hex-2-enes and α, α-Dibromo imines from N‑Allyl Enamine March 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00217F, Research ArticleXiyan Duan, Junqi Wang , Kun Liu , Fengjiao Du, Maoling He, Wenxin Li, Xinming Liu, Pu LiuBy varying the halide type and its addition rate, the divergent synthesis of dibromo 1-pyrrolines, 3-azabicyclo[3.1.0]hex-2-enes, and α, α-dibromo imines from N-allyl enamine was successfully achieved. 1-Pyrrolines and 3-azabicyclo[3.1.0]hex-2-enes are...The […]Xiyan Duan
- A DFT Investigation on the Mechanism of Photoinduced Radical Borylation of Alkyl Bromides: Elucidation for Base-Mediated Photoinduced SET and SN2 Processes March 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00048C, Research ArticleNana Ma, Qiongjin Wang, Die Zhao, Bowen Duan, Shujun Li, Guisheng ZhangThe transition-metal-free borylation of alkyl halides has received widespread attention due to environmental and economic considerations. Particularly, the visible-light-induced radical borylation of alkyl halides catalyzed by 4-phenylpyridine has been achieved,...The content of this RSS Feed (c) […]Nana Ma
- Construction of chiral γ-lactam scaffolds via asymmetric cascade [3+2] annulation of N-alkoxyacrylamides catalyzed by a chiral-at-metal rhodium complex March 29, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00276A, Research ArticleWan-Shun Cheng, Yong-Bing Ke, Yang Chen, Hui-Ting Cui, Rui-Qiu Zhang, Helin Lu, Ping Xue, Xiaobo Wang, Shi-Wu Li, Jun GongAn efficient asymmetric cascade [3+2] annulation of N-alkoxyacrylamides with α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium complex has been developed. The enantioenriched γ-lactam derivatives bearing three contiguous […]Wan-Shun Cheng
- Asymmetric oxidative rearrangement of indoles enabled by dual catalysis with in situ generated acyl hypoiodite and chiral phosphoric acid March 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00302D, Research ArticleHaowei Gao, Xihui Yang, Lei ShiA dual catalytic asymmetric oxidative rearrangement of indoles via traceless halonium intermediates. This halide-catalyzed method features excellent enantioselectivity and broad functional group tolerance, including late-stage complex targets.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Haowei Gao
- Catalytic (5+1) Cycloaddition of Diazooxindoles with Imidazolidines to Access Novel Piperazine-Spirooxindole Frameworks March 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00361J, Research ArticleYijun Duan, Feng Chen, Yuncheng Liu, Wendi Xu, Xue Zhang, Ming Lang, Shiyong PengHerein, a catalytic (5+1) cycloaddition of diazooxindoles with imidazolidines is described, providing a general and efficient synthetic route to medicinally attractive piperazine-spirooxindole frameworks in moderate to good yields under rhodium...The content of this RSS […]Yijun Duan
- Fe-Catalyzed B-H and N-H Insertion Reactions of Iodonium Ylides March 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01916D, Research ArticleHejun An, Zhi Cui, Jinchao Liang, Xingxing Ma, Jinglong Chen, Qiuling SongThe difunctionalization of olefins as an effective synthetic strategy has garnered significant attention among organic synthetic chemists, thus enabling complex molecular scaffolds to be assembled in a single step from...The content of this RSS Feed (c) […]Hejun An
- Palladium-catalyzed Z-alkenylative cross-coupling via β-alkenyl elimination of Z-allylic alcohols March 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00110B, Research ArticleXue-Mei Huang, Cheng Liang, Si-Qi Xiong, Xue Zhang, Kai-Xian Ma, Qing-Hua Li, Tang-Lin LiuThe transition metal-catalyzed Z-alkenylative cross-coupling has been well developed, but limitation remains with this methodology. Herein, we reported a Z-alkenylative cross-coupling between Z-allylic alcohol and aryl bromides. The Z-alkenyl palladium...The content of this RSS […]Xue-Mei Huang
- EDA Complex Photochemistry as a Strategy for C–S Bond Formation March 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00258C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Helena Fernández Piedra, Illán Tagarro, Manuel PlazaThis review highlights the use of photochemically excited electron donor–acceptor (EDA) complexes as a sustainable, modern approach to carbon–sulfur bond formation. C–S bonds are essential in […]Helena Fernández Piedra
- Solvent-controlled 4CzBnBN-catalyzed Intramolecular Photocyclization and Dehydrogenative Photocyclization of Indolecarboxamides for the switchable synthesis of indoloquinolones and dihydroindoloquinolones March 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00185D, Research ArticleYihao Zhang, Peng Zhang, Hang Zhao, Xing Wang, Xia Zhou, Yimou Gong, Lin Wang, Siping Wei, Zhijie Zhang, Qiang FuIndoloquinolones and dihydroindoloquinolones are in-demand motifs in medicinal chemistry, yet methods for the controlled synthesis both molecules are scarce. We detail the solvent-controlled switchable photocyclization and dehydrogenative photocyclization […]Yihao Zhang
- 8,14-seco-ent-Kaurane Diterpenoids from Isodon glutinosus: Enol-Enol Tautomerism and Antitumor Activity March 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00356C, Research ArticleYang-Yang Fu, Kun Hu, Song-Yu Hou, Bing-Chao Yan, Xiao-Nian Li, Xing-Zhi Yang, Han-Dong Sun, Pema-Tenzin PunoGlutinosasins A–D (1–4), four novel 8,14-seco-ent-kaurane diterpenoids featuring an β-carbonyl enol moiety, along with glutinosasin E (5), a new ent-kaurane diterpenoid, were isolated from the aerial part of Isodon glutinosus....The content of […]Yang-Yang Fu
- Iron-catalyzed Regioselective Carboazidation of Alkenes for the Synthesis of Multi-substituted Cyclobutylamines March 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00173K, Research ArticleYufei Li, Yajun Li, Hongli BaoCyclobutylamines are versatile synthetic frameworks with significant applications in pharmaceuticals and natural products. Herein, we report an iron-catalyzed carboazidation of alkenes, enabling the regioselective synthesis of multi-substituted cyclobutylamines. This method...The content of this RSS Feed (c) The Royal Society of ChemistryYufei Li
- Photoredox-catalyzed three-component alkylation of glycine derivatives and peptides via a site-selective 1,5-hydrogen atom transfer cascade March 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00294J, Research ArticleHongying Fan, Liulin Jiao, Ting Yuan, Jian Chen, Qingyun Gu, Xue Zhang, Jinyu Hou, Zhongzhen Yang, Li Guo, Yong WuWe report a visible-light-mediated three-component reaction via 1,5-HAT combined with site-selective remote C(sp3)–H cross-coupling reactions of alkenes with alkyl radicals for the α-C(sp3)–H alkylation of glycine derivatives and […]Hongying Fan
- Visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-hydrogen atom transfer (1,5-HAT) March 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00031A, Research ArticleYafei Zhu, Penghua Zhang, Xingqin Tian, Xueqin Wang, Mi Wang, Cuimei Zhang, Jian Chen, Jing Zhang, Guanghui Lv, Yong WuWe reported the first example of visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-HAT, which is characterized by broad substrate scope, excellent functional group compatibility and no requirement […]Yafei Zhu
- Metallaphotoredox-enabled Enantioselective Aryldifluoromethyl-alkynylation of Alkenes via C(sp3)-F Bond Activation March 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00370A, Research Articlejialin Huang, Liying Fu, xiaofei Zhao, Xingda Zhao, Zhanyong Tang, Xiaoqiang Ma, Depeng ZhaoDue to the prevalence of trifluoromethylarenes (ArCF3) units in drug-related molecules, direct late-stage functionalization of C(sp3)-F bonds in ArCF3 offers an appealing strategy for rapid derivatization of ArCF3-containing drugs, and...The content of this RSS […]jialin Huang
- Unveiling stereoselective ladders via photo-oligomerization of a diazaanthracene macrocycle March 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00159E, Research ArticleJinti Moni Kumar, Ivan Huc, Yann Ferrand, Bappaditya GoleWe present an efficient light-driven oligomerization of flat aromatic tetra-amide macrocycles containing photoresponsive 1,8-diazaanthracenes. Oligomers with molecular weights exceeding 10 kDa were straightforwardly obtained, isolated using gel permeation chromatography (GPC),...The content of this RSS Feed (c) The Royal Society […]Jinti Moni Kumar
- Carbene-Catalyzed Imine Reductive Reaction: A New Application of Breslow Intermediate March 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00332F, Research ArticleHui Zhu, Han Xiao, Lihe Wang, Bo Jiang, Qingyun Wang, Shuquan Wu, Pengcheng Zhengα-Amino acids are vital structural motifs widely present in functional molecules. Catalytic hydrogenation and transfer hydrogenation of imine are significant methods for constructing α-amino acid. The general hydrogenation process often...The content of this RSS […]Hui Zhu
- Copper-Catalyzed anti-Stereoselective 1,2-Silylamination of Alkynes March 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00040H, Research ArticleKelu Yan, Xiaoyu Wang, Jiangwei Wen, Qiuyun Li, Jianjing Yang, Xinru Tao, Shenghao Pan, Haosheng Liang, Xiu WangHighly substituted alkenes are important synthetic intermediates for pharmaceuticals, and the development of such compounds provides a variety of potential alkene monomers for functional polyolefin molecules. At present, a series...The […]Kelu Yan
- Ni-catalyzed regio- and diastereoselective syn-alkynylamination of unactivated alkenes with alkylamine sources March 24, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00194C, Research ArticleYixuan Wan, Cong Lin, Yihuan Cheng, Liang ShenThe three-component alkynylamination of alkenes provides a prevalent and powerful platform to rapid access to homopropargyl amines. However, the use of alkylamines to achieve this transformation remains a significant challenge....The content of this RSS Feed (c) The Royal Society of […]Yixuan Wan
- Intramolecular and intermolecular benzannulation of arylethanone derivatives enabled by visible light-induced catalytic generation of tether-tunable distonic radical anions March 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00271K, Research ArticleZhiyou Yu, Ziye Zhan, Kang Fu, Lei ShiA novel method enables inter-/intramolecular benzannulation to synthesize PAHs have been disclosed. Experimental and DFT data confirm the TDRA's role in the HAA step of enolized 1,3-dicarbonyls via asynchronous PCET.To cite this article before page numbers are assigned, use the […]Zhiyou Yu
- Palladium-catalysed asymmetric regioselective hydroamination of dienoates March 30, 2025
