RSC – Org. Chem. Front. latest articles- Access to benzo[e][1,3]thiazin-4-ones via PCy3-mediated annulations of benzo[c][1,2]dithiol-3-ones with iso(thio)cyanates August 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01013F, Research ArticleChengxiang Yi, Mingyang Zhu, Jie Ren, Weimin Zhu, Chuanjun Song, Yangang WuHerein, we describe a novel organophosphine-mediated annulation reaction of benzo[c][1,2]dithiol-3-ones with iso(thio)cyanates, which proceeds via an S atom to C-N unit exchange strategy. The methodology efficiently produced a variety of...The content of this RSS Feed (c) […]Chengxiang Yi
- Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines August 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00961H, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amit Kumar, Kritika Dogra, Basab Bijayi DharA copper-catalyzed method has been developed for synthesizing β-amino ketones using allyl alcohols and substituted anilines in 2-methyl-THF at 60 °C. This reaction employs hydrogen peroxide […]Amit Kumar
- Photocatalytic α-nucleophilic fluorination of α,β-unsaturated carbonyl compounds August 1, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00877H, Research ArticleFang Wang, Jie Gong, Yan-Biao Kang, Jian-Ping QuA redox-neutral photocatalytic α-nucleophilic fluorination of α,β-unsaturated carbonyls under mild conditions enables access to α-fluorinated carbonyls via an α-carbonyl cation, with potential for late-stage fluorination of bioactive molecules.To cite this article before page numbers are assigned, use the DOI form […]Fang Wang
- Anionic 5-endo-dig cyclizations: an experimental investigation of in-plane aromaticity involving a non-enolate carbanion nucleophile July 31, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00547G, Tutorial Account Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kristina M. Nugent, Silas Q. Hintze, Pradip Maity, Salvatore D. LeporeCyclitive additions of aliphatic carbanions to non-electrophilic carbon–carbon triple bonds under mild, transition-metal-free conditions are described for the first time.To cite this […]Kristina M. Nugent
- From Nonporous to Porous: Carbazole-Integrated π-Conjugated Pillar[5]arene Crystals for Enhanced Iodine Capture July 31, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO01006C, Research ArticleJin-Fa Chen, Xu-Xu Jia, Xiao-Peng Ling, Yu-Xi Yuan, Bingbing Shi, Qi Lin, Hong Yao, Tai-Bao WeiHerein, we present a case of transforming from a nonporous crystal to a porous crystal, achieved by molecular functionalization of a perethylated pillar[5]arene using two carbazole units. The porous crystal...The content of […]Jin-Fa Chen
- Theoretical Insights into the Mechanism and Selectivities of Rhodium/Amine Dual Catalysis in Alkyne-Cyclopropene Reassembly Reactions July 31, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00898K, Research ArticleGuanghui Song, Keying Zhang, Huan Wang, Juan LiRhodium/amine dual catalysis has recently emerged as a powerful strategy for C–C bond reconstruction between cnjugated alkynes and cyclopropenes, offering new opportunities for complex molecule synthesis. In this work, we...The content of this RSS Feed (c) The Royal Society of […]Guanghui Song
- Electrophilic Intermolecular Halo-Phosphorothiolation and Phosphorothiolation-Dearomatization of Alkenes/Alkynes with N-Phosphorothiosuccinimide July 31, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00959F, Research ArticleYuan Zhang, Mingyang Chen, Xu Chen, Xuesi Zhou, Yitai Fu, Xiang Liu, Hua CaoElectrophilic phosphorothiolations represent an attractive strategy that has been rarely explored due to the lack of practical electrophilic reagents. Herein, we developed electrophilic phosphorothioate transfer reagents and unveiled their synthetic...The content of this RSS […]Yuan Zhang
- Modular assembly of 4-trifluoromethyl substituted 2-imino-1,3-oxathioles via cobalt(II)-based metalloradical catalysis July 31, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00989H, Research ArticleChengxiao Liu, Baiquan Wang, Bin LiWe report herein a cobalt(II) metalloradical-mediated cycloaddition of α-trifluoromethyl-α-diazoketone with isothiocyanate, which led to the modular formation of 4-trifluoromethylated 2-imino-1,3-oxathioles from easily accessible starting materials with high efficiency. Moreover, the...The content of this RSS Feed (c) The Royal Society of ChemistryChengxiao Liu
- Cationic and Homoleptic Copper(I)–Thiazol-2-ylidenes: Highly Reactive Thiazole N-Heterocyclic Carbenes σ-Lewis Acid Catalysts July 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00772K, Research ArticleRuihong Wang, Jin Zhang, Hang Yang, Yawei Zhu, Yan Guo, Xiaoxia Han, Roman Szostak, Michal SzostakAir- and moisture-stable cationic homoleptic Cu(I) thiazol-2-ylidene complexes are developed as highly efficient σ-Lewis acid catalysts, outperforming imidazol-2-ylidenes in the alkynylation of ketones without requiring stoichiometric Cu-acetylides. These complexes exhibit...The content of […]Ruihong Wang
- Beyond Energy Transfer: Ground-State Association-Driven [2+2] Cycloadditions with Indole-Fused Organophotocatalysts July 30, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00774G, Research ArticleSeoyeon Kim, Byung Hak Jhun, Yunjeong Lee, Gayeon Lee, Sihyun Woo, Jaehahn Bae, Sohee Lee, Seoyeon Kim, Youngmin You, Eun Jin ChoA visible-light-driven [2+2] cycloaddition strategy with indole-fused organophotocatalysts (organoPCs) developed in our laboratory is presented, highlighting a sustainable approach with minimal solvent usage and no sacrificial […]Seoyeon Kim
- Transition-Metal-Free [3+2] Cycloaddition to Access Tetrazoles: Non-radical Application of Arylazo Sulfones July 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00840A, Research ArticleYulei Zhao, Ruiqing Wang, Xinyu Zong, Wenyi Chen, Xintian Zhang, Minghui ZhangA transition-metal-free [3+2] cycloaddition between arylazo sulfones and diazo compounds is reported. Notably, arylazo sulfones demonstrate distinct reactivity characteristics; in contrast, other common azo compounds and aryldiazonium salts prove ineffective...The content of this RSS Feed (c) […]Yulei Zhao
- Tunable thiofumarate stereoselective cycloadditions via aminomefloquine catalysis July 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO01014D, Research ArticleRadosław Suchanek, Michał Błauciak, Anna Spyszkiewicz, Błażej Dziuk, Przemysław J. Boratyński, Rafał Szabla, Rafał KowalczykNorcamphane dicarboxylic acid ester thioester derivatives are obtained with high enantioselectivity via a formal cycloaddition reaction using amino-mefloquine catalysis.To cite this article before page numbers are assigned, use the DOI form of citation […]Radosław Suchanek
- An asymmetric biomimetic aldol reaction of glycinate with aliphatic aldehydes for efficient synthesis of chiral β-hydroxy-α-amino acid esters July 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00653H, Research ArticleTao Liu, Dong Ma, Mingming Lu, Ting Ma, Siqi Liu, Guoqing Zhao, Baoguo ZhaoA direct asymmetric aldol reaction of glycinate with aliphatic aldehydes was developed in the presence of a chiral pyridoxal catalyst.To cite this article before page numbers are assigned, use the DOI form of citation […]Tao Liu
- Substrate-Controlled Regioselective Dibenzylation of Enaminones July 28, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00972C, Research ArticleXiuju Wang, Jin Zhang, Xingyu Zhao, Yiran Wang, Jinwen Sima, Zihan Wang, Xue Jia, Siyu Song, Fuchao YuA substrate-controlled α,α-dibenzylation and O-benzylation-α-benzylation reaction of enaminones with benzyl bromides has been described. This divergent strategy provides efficient access to a new class of structurally diverse α,α-dibenzylated products and...The […]Xiuju Wang
- Origin of ligand-controlled regioselectivity in Co-catalyzed borylation of fluorinated arenes July 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00897B, Research ArticleXiaofang Zhai, Han Gao, Feng Ye, Wujie Wang, Yuliang Li, Gang LuThe mechanism and origins of regioselectivity in cobalt-catalyzed borylation of fluorinated arenes were computationally investigated. The results reveal that cobalt catalysts bearing two distinct pincer ligands exhibit different regioselectivity-determining steps....The content of this RSS Feed (c) […]Xiaofang Zhai
- NHC/Photoredox Dual Catalysis Directs N-methyl Radical Coupling for Decarboxylative Synthesis of α-N-Aryl amino Ketones July 27, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00923E, Research ArticleWenying Zhao, Weikun Zeng, Shilin Zhou, Jun Zhou, Yi JinHerein, a synergistic NHC/photoredox system enables α-arylamino ketone synthesis via stabilized N-methyl radical intermediates, overcoming competitive dimerization. Key innovations include base-mediated N-methyl radical generation and acyl azolium intermediate-guided cross-coupling, steering...The content of this RSS Feed (c) The Royal […]Wenying Zhao
- Visible-light or sunlight-driven copper catalysis for base-free synthesis of β-diketones via radical acylation of enol silyl ethers July 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00827A, Research ArticleXun Yang, Mingyang Yang, Siyi Qin, Haiyan Li, Wengui Duan, Jingshu Han, Lin YuA general method for accessing β-diketones through visible-light or sunlight photoredox-catalyzed radical acylation of enol silyl ethers has been developed.To cite this article before page numbers are assigned, use the DOI form of citation […]Xun Yang
- Access to chiral α-methyl-α-aryl carboxylic acids via phosphoric acid-catalyzed kinetic resolution of biaryl oxazepines July 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00953G, Research ArticleGuimei Dai, Yifei Ma, Weiwei Tan, Ting Tu, Bowen Zhu, Zhikang Wei, Liejin Zhou, Shichao Ren, Xing YangA chiral phosphoric acid-catalyzed kinetic resolution of racemic biaryl oxazepines with alcohols was developed, which afforded biaryl oxazepines and imidates bearing a chiral center in high enantioselectivities.To cite this article […]Guimei Dai
- Synthesis of multisubstituted cyclohexenes and cyclopentenes via cascade Michael/aldol/annulative SuFEx/β-sultone desulfonation of β-arylethenesulfonyl fluorides July 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00837A, Research ArticleFang Zhang, Qichao Zhang, Pei Xie, Qifan Wang, Lin He, Zhihua Cai, Guangfen Duγ- and β-Ketomalononitriles react with β-arylethenesulfonyl fluorides via a cascade Michael addition/aldol reaction/annulative SuFEx/β-sultone desulfonation process to produce multisubstituted cyclohexenes and cyclopentenes.To cite this article before page numbers are assigned, use the DOI form […]Fang Zhang
- Utilisation of CO2 in the Simultaneous Installation of the C—C and C=C Bonds of α,β-Unsaturated Carboxylic Acids July 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00770D, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Amy Lowry, rachel E Lynch, Gerard P. McGlacken, Peter ByrneDevelopment of methods for the conversion of CO2 (a major waste product) into value-added chemicals has become an area of great interest. Herein […]Amy Lowry
- Access to benzo[e][1,3]thiazin-4-ones via PCy3-mediated annulations of benzo[c][1,2]dithiol-3-ones with iso(thio)cyanates August 4, 2025
