RSC – Org. Chem. Front. latest articles- Palladium-catalyzed site-selective C−H polyfluoroarylation of arenes via aryl thianthrenium salts May 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00473J, Research ArticleChen Chen, Jin-Ping Liu, Xin-Yu Hu, Zi-Yi Wang, Xiao-Xu Zhang, Jia-Hui Song, Yan-Ping Zhu, Chunjie Ni, Bolin ZhuThis study introduces a novel method for the selective formal C−H/C−H cross-coupling of arenes with polyfluoroarenes via aryl thianthrenium salts under palladium catalysis, resulting in the production of a range...The […]Chen Chen
- Cs2AgBiBr6-Photocatalytic Trifluoromethylation: Insights in Structural Changes and Applications in Drug Modification May 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02237H, Research ArticleDebin Yang, Yalin Guo, Yuanzhe Li, Bo Hu, Bing Yu, Qingchuan DuanThe development of new drugs involves complex processes of molecular design, drug screening, and clinical validation, where structural modifications play a crucial role. The trifluoromethyl (CF3) group is significant in...The content of this RSS Feed (c) […]Debin Yang
- Access to ester-substituted γ-butyrolactones via photocatalyzed alkoxycarbonylation/lactonization of alkenoic acids May 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00520E, Research ArticleYuping Xiong, Ping Liang, Wenlin Xie, Jian-Qiang Chen, Jie WuWe reported a versatile and concise method to realize the photoredox-induced alkoxycarbonylative lactonization of alkenoic acids for the construction of ester-substituted γ-butyrolactones. This method achieves a multistep cascade reaction by...The content of this RSS Feed (c) The Royal […]Yuping Xiong
- Cu-Catalyzed Regiodivergent and Stereoselective Silylation of 2,3-Disubstituted 1,3-Dienes May 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00512D, Research ArticlePinglu Zhang, Ziwei Luo, Hao Zeng, Junyang Cen, Ze Li, Guoqiao LaiRegiodivergent silylation of conjugated dienes represents an elegant and straight forward approach to access diverse organosilicon compounds. While the silylation of 1- or 2- substituted conjugated dienes has been well...The content of this RSS Feed (c) […]Pinglu Zhang
- Catalyst-Controlled 5-exo and 6-endo Cyclization: Regiodivergent Access to Indolinones and Dihydroquinolinones May 6, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00516G, Research ArticleXianzhou Zheng, Youzhi Xu, Genping Huang, Weiming YuanFive- and six-membered benzo-fused lactams are important and prevalent scaffolds in many natural products and biologically active compounds. In spite of considerable advances toward their synthesis, the intramolecular alkene functionalization...The content of this RSS Feed (c) The Royal Society of […]Xianzhou Zheng
- Fluorine-Containing Macrocyclic Peptides and Peptidomimetics May 5, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00219B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stefan Roesner, Neshat RozatianFluorination plays a vital role in medicinal chemistry due to the unique properties of the fluorine atom. Macrocyclic peptides offer advantageous properties compared to linear peptides in drug discovery. […]Stefan Roesner
- Design and Synthetic Utility of New HAT Organocatalysts Derived from Commercially Available Diamines May 5, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00509D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jingwen Jia, Terumasa Kato, Keiji MaruokaA series of hydrogen-atom transfer (HAT) organocatalysts were conveniently prepared from commercially available diamine compounds, and their utility in photoinduced HAT catalysis ability was investigated. The combination […]Jingwen Jia
- Synergistic catalytic allenylic alkylation for stereodivergent construction of allenes bearing 1,3-axial central chirality May 4, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00467E, Research ArticleMin Chen, Yuzhen Li, Jun He, Lili Lin, Liang-Wen Feng, Xiaohua LiuA highly efficient asymmetric allenylic alkylation for the construction of allenes bearing allenyl axial and central chirality through synergistic Ni/Pd catalysis has been developed. This catalytic protocol operates smoothly under...The content of this RSS Feed (c) […]Min Chen
- Beyond HAT: Harnessing TBADT for photocatalyzed Giese-type C(sp3)-C(sp3) Bond Formation through Reductive Decarboxylation May 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00399G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matteo Leone, Dalila Arnaldi, Maurizio FagnoniPhotocatalysis has become a powerful tool for developing sustainable synthetic methods, with the decatungstate anion (TBADT) playing a pivotal role. TBADT facilitates a variety of chemical transformations […]Matteo Leone
- Mechanistic insights into ligand-controlled diastereoselectivity in iridium-catalyzed stereoselective coupling of allylic ethers and alkynes: a DFT perspective May 2, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00343A, Research ArticleManzhu Zhao, Lihan Zhu, Qian Zhang, Jingping ZhangRegulating the diastereoselectivity of a reaction is highly attractive but extremely challenging, density functional theory computations are employed to investigate an iridium-catalyzed ligand-controlled diastereoselectivity switch propargylic C−H functionalization. Energetically most...The content of this RSS Feed (c) The Royal Society of […]Manzhu Zhao
- Copper-catalyzed aryl ortho-C–H thiolation of aldehydes via a transient directing group strategy April 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00472A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingshun Mei, Dongsheng Yi, Fanyi Meng, Junhao Tang, Yanghui ZhangThe Cu-catalyzed C–H thiolation reaction of aromatic aldehydes has been developed via a transient directing group strategy.To cite this article before page numbers […]Mingshun Mei
- Tetraphenylethylene or naphthalimide-functionalized dendritic carbazole AIEgens: self-assembly visualization, three disparate force-triggered fluorescence responses, and advanced anticounterfeiting applications April 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00393H, Research ArticleYijie Zou, Zhao Chen, Fei Zhao, Ya Yin, Kaixin He, Xingru Liang, Hai-feng He, Zhijian Li, Sheng Hua LiuSix dendritic AIEgens exhibiting self-assembly and three distinct types of force-responsive emissive features are developed, and two advanced information security systems are constructed.To cite this article before page numbers […]Yijie Zou
- Enantioselective construction of cycloalkyl amines via nickel-catalysed alkene desymmetrization April 28, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00590F, Research ArticleLudi Li, Bo Chen, Wenxu Cao, G. V. Surendra Babu, Weike Liao, Pengli Zhang, Guoqin XiaEnantioselective construction of cycloalkyl amines with two adjacent chiral centers via transannular directed, NiH-catalysed cycloalkene desymmetric hydroalkylation.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]Ludi Li
- Synthesis of 8-membered trifluoromethyl benzoxazocines via a Pd-catalyzed ring-expansion reaction of trifluoromethyl benzoxazinones with 2-methylidenetrimethylene carbonate and mechanistic investigations April 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02076F, Research ArticleBo Yang, Peng-Fei Sun, Xue Ma, Zhouyang Long, Li-Ming ZhaoA Pd-catalyzed ring-expansion reaction of trifluoromethyl benzoxazinones with 2-methylidenetrimethylene carbonate to access 8-membered trifluoromethyl benzoxazocines is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Bo Yang
- Multicomponent synthesis of unsymmetrical 1,2-diamines via photo-induced carbonyl alkylative amination April 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00479A, Research ArticleZhuohua Li, Wenjie Yan, Xiao Zhou, Chao Yang, Lin Guo, Wujiong XiaA photo-induced carbonyl alkylative amination for the synthesis of alkyl/aryl-substituted unsymmetrical 1,2-diamines is herein reported under catalyst- and base-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Zhuohua Li
- Enantioselective and diastereodivergent construction of oxindole–pyrazolone conjugates bearing an alkenyl substituted quaternary chlorinated stereogenic centre April 27, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00499C, Research ArticleJiapei Chen, Xusheng Duan, Mengyuan Wu, Guishun Bai, Jianwei Chen, Xuanrong Sun, Jean Rodriguez, Damien Bonne, Hong Wang, Xiaoze BaoAn enantioselective and diastereodivergent construction of an oxindole and pyrazolone scaffold bearing an alkenyl-substituted quaternary chlorinated stereogenic centre is developed.To cite this article before page numbers are assigned, […]Jiapei Chen
- Regioselective C–H alkynylation with haloalkynes enabled by nitrogen functionalities via Rh catalysis April 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00578G, Research ArticleQiaoya Zhang, Bifu Liu, Ci Chen, Yinling Li, Kejun Feng, Sheng Hu, Yang Gao, Yanping Huo, Qian Chen, Xianwei LiHerein, we developed a transformable nitrogen functionality enabled regioselective C–H alkynylation cascade with aliphatic haloalkynes, furnishing alkynes and heterocycles, which thus facilitated concise delivery of CB2 receptor agonist, […]Qiaoya Zhang
- Copper catalyzed aerobic oxidation of aldehydes to carboxylic acids April 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00330J, Research ArticleYankai Huang, Sheng Jiang, Zhengnan Zhengnan Zhou, Yibo Yu, Hui Qian, Shengming MaAn efficient practical aerobic oxidation of aldehydes to carboxylic acids using O2 or air as the oxidant has been developed. The reaction was carried out with a catalytic amount each...The content of this RSS Feed […]Yankai Huang
- 1,2 Wagner-Meerwein Shift in Aza-Nazarov Cyclization: Bi(III)-Catalyzed Substrate-Dependent Divergent Synthesis of Highly Substituted Pyrroles and Indenes April 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00168D, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Deepak Datta Gaonkar, Shon Gangai, Krishna Appasaheb Mhaske, Rishikesh NarayanNazarov reaction and its variants such as Aza-Nazarov and Iso-Nazarov cyclizations are versatile methods for the synthesis of five-membered ring systems including pyrroles […]Deepak Datta Gaonkar
- A Cascade Markovnikov Addition / Lewis Acid-Catalyzed Rearrangement of Methyleneaziridines and Carboxylic Acids: Continuous-Flow Synthesis of α-Amidoketones April 24, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00495K, Research ArticleBin Pan, Haotian Sun, Feng Li, Qing-Bao Zhang, Shanshan Zhang, Jia-Hao Wang, Meng-Rui Xu, Jing-Tian Ge, Zi-Qing Hu, Shang Lv, Lijuan Feng, Guofu Huangα-Amidoketones are essential structural motifs in pharmaceuticals and synthetic chemistry. In this study, we describe a novel synthetic method that involves a cascade addition […]Bin Pan
- Palladium-catalyzed site-selective C−H polyfluoroarylation of arenes via aryl thianthrenium salts May 6, 2025
