RSC – Org. Chem. Front. latest articles- One-pot C2-arylation and C4-acetoxylation of tryptophan derivatives via palladium-catalyzed tandem C–H activation June 25, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00671F, Research ArticleJia-Tian Liu, Jiashu Liu, Qi-Long Hu, Jian LiPalladium-catalyzed C2-arylation and C4-acetoxylation of indole within tryptophan derivatives was achieved in one pot by employing a TfNH–directing group.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Jia-Tian Liu
- Additive-Free Four-Component Radical Selenosulfonylation of Alkenes June 25, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00812C, Research ArticleMing-Qi Yang, Ying Tong, Jun-Qi Liu, Shi-Qing Zhang, Jia-Yao Feng, Hong-Lin Wu, Jin-Yang Chen, Jun-Qi Zhang, Hongxia Wang, Wenting WeiWhile multicomponent tandem reactions offer an efficient platform for the difunctionalization of alkenes, the precise regulation of component ordering in reaction systems remains a persistent challenge. Herein, we […]Ming-Qi Yang
- Correction: NaH-promoted one-pot oxidation/aromatization and C-3H chalcogenation of indoline: atmospheric control-based selective intermediates June 24, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO90050F, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Suman Majee, Km. Anjali, Shaily Agarwal, Vishnu Poonia, Alok Kumar Singh, Biswajit Guchhait, Devalina RayTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]Suman Majee
- Regioselective Synthesis of C6-alkylated Indoles Utilizing Electronic-Steric Effect Enabled by Imino Exchange and Phosphorus Ylides Addition June 24, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00344J, Research ArticleHaitian Zhu, Qiuqin He, Renhua Fan, Jiwen HeWe reported herein the regioselective synthesis of C6-alkylated indoles utilizing electronic effect enabled by imino exchange and steric effect of phosphorus ylides addition. The protocol adopted readily available P-ylides as...The content of this RSS Feed (c) The Royal Society of […]Haitian Zhu
- Synthesis of N-Trifluoromethylsulfilimines via Trifluoromethyl Nitrene and Their Synthetic Potential June 24, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00873E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Norbert Baris, Martin Dracinsky, Luca Julianna Tóth, Blanka Klepetarova, Petr BeierTrifluoromethyl nitrene generated photocatalytically from azidotrifluoromethane added to sulfides to afford new N-trifluoromethylsulfilimines. Their methylation yielded N-methyl-N trifluoromethyl sulfonium salts and oxidation […]Norbert Baris
- One-pot modular synthesis of 3-oxazolines from 2H-azirines, diazo compounds, and m-CPBA enabled by 2-azadiene–oxene (4 + 1) cycloaddition June 23, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00717H, Research ArticleIlya P. Filippov, Mikhail Sergeevich Novikov, Nikolai V. RostovskiiA formal (4 + 1) cycloaddition of oxene occurs in the reaction of 2-azabuta-1,3-dienes with m-chloroperoxybenzoic acid under mild conditions to give 3-oxazolines. Mechanistically, the reaction is an extended Prilezhaev...The content of this RSS Feed (c) The Royal Society […]Ilya P. Filippov
- Au/Ag Synergistic Catalyzed Synthesis of 4H-imidazo-oxadiazin-4-ones via Three-Component Domino Cascade Cyclization June 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00540J, Research ArticleDongfang Jiang, Zhenjie Qi, Haifei Wang, Feng Liu, Can Yang, Xin Li, Hongchi ZhouA novel and efficient method for synthesizing a wide range of 4H-imidazo-oxadiazin-4-ones was achieved through a three-component domino cascade cyclization reaction of N-tosylhydrazones with α, β-unsaturated acids and amines, utilizing...The content of this RSS […]Dongfang Jiang
- Bunte salts-mediated sulfonation of alkenes with sodium sulfinatessulfinates June 22, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00618J, Research ArticleKemeng Zhang, Shuodan Ding, Jie Zhou, Xinyu Zhou, Ge Wu, XinLei WuBunte salts are frequently utilized as effective thiolation reagents for constructing thioethers. In this study, we discovered that Bunte salts could also serve as mediators to enable the oxidative C-H...The content of this RSS Feed (c) […]Kemeng Zhang
- Synthesis of 1,2-oxaborole via base-mediated borylation of propynols June 20, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00709G, Research ArticleSumit Ghosh, Sudip Laru, Mukta Singsardar, Alakananda HajraA one-step catalyst-free method has been reported for the efficient synthesis of valuable 1,2-oxaborole derivatives via borylation of propynols using only cesium carbonate as a base under mild reaction conditions.To cite this article before page numbers are assigned, use the […]Sumit Ghosh
- Radical 1,4-acylcyanoalkylation of alkenes for the synthesis of ζ-ketonitriles June 19, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00744E, Research ArticleYing Tong, Jia-Yao Feng, Cuiyan Wu, Shi-Qing Zhang, Ming-Qi Yang, Sheng Du, Dong-Qing Yang, Keqi Tang, Chao Deng, Wen-Ting WeiTwo-component alkene coupling reactions serve as an efficient platform for the synthesis of complex molecular architectures.To cite this article before page numbers are assigned, use the DOI form […]Ying Tong
- Cu/chiral phosphoric acid-catalyzed asymmetric (3 + 2) cycloaddition of donor–acceptor aziridines with aldehydes: synthesis of enantioenriched oxazolidines as potential antitumor agents June 19, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00729A, Research ArticleZhichao Shi, Tingting Fan, Jin-Shun Lin, Weibin Xie, Feng Zhan, Zhe Wang, Qinglu Zuo, Haoran Fu, Xun Zhang, Qiuhua Huang, Yuyang JiangCu(II)/chiral phosphoric acid-catalyzed asymmetric (3 + 2) cycloaddition of donor–acceptor aziridines with aldehydes to synthesize enantioenriched oxazolidines as potential antitumor agents.To cite this article before page […]Zhichao Shi
- Radical di- and multi-functionalization of alkenes: recent advances in diverse reaction modes utilizing TBHP as reactants June 19, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00785B, Review ArticleJiantao Zhang, Renhua Su, Weibing LiuWe summarize the recent progress in TBHP-enabled transformations of alkenes, which are categorized as peroxidation, carbonylation, epoxidation, etherification, hydrogenation, and hydroxylation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]Jiantao Zhang
- Rhodaelectro-catalyzed C–H activations directed by pharmacophores: enabling modification of bioactive compounds June 18, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00808E, Research ArticleShangyong Wu, Binbin Yuan, Yongke Lei, Xiaoli Su, Tristan von Münchow, João C. A. Oliveira, Xuewu Huang, Zhaojun Ding, Rongrong Xu, Lutz Ackermann, Jiayu MoIn the realm of sustainable molecular synthesis, metallaelectro-catalysis has emerged as a highly potent platform over the past decade.To cite this article before […]Shangyong Wu
- Sulfur/selenium atom-incorporated hetero[7]helicenes for low-temperature circularly polarized phosphorescence June 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00790A, Research ArticleShuai Qiu, Yuexia Dong, Wan Xu, Sheng Zhang, Chunli Li, Hua WangThree new thiophene/selenophene-based S/Se-[7]helicenes were efficiently synthesized via intermolecular McMurry and oxidative photocyclization reactions. These [7]helicenes exhibited notable circularly polarized phosphorescence at 77 K.To cite this article before page numbers are assigned, use the DOI form […]Shuai Qiu
- Radical-polar crossover cyclization: visible-light-induced synthesis of γ-alkylated 1,1-disubstituted cyclopropanes via 1,6-hydrogen atom transfer June 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00670H, Research ArticleMeiling Ye, Hang Wang, Min Liao, Zeyu Tian, Zhongzhen Yang, Yong WuA visible-light-induced radical-polar crossover cyclization (RPCC) reaction between homoallylic substrates and sulfamate esters for the synthesis of γ-alkylated 1,1-disubstituted cyclopropanes via 1,6-HAT processes has been reported.To cite this article before page numbers are assigned, use the […]Meiling Ye
- Room-temperature nickel-catalyzed borylation/cyclization for the synthesis of benzoxaboroles and benzodiazaborines June 12, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00728C, Research ArticleXiaoning Yang, Shuyan Wu, Jiayi Wang, Yanqing Peng, Gonghua SongHerein, we present a room-temperature, nickel-catalyzed borylation protocol for the efficient synthesis of benzoxaboroles and benzodiazaborines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]Xiaoning Yang
- Bicyclic 2-Pyridone, with Fused Heterocyclic Rings, a Facile Core for Pure Type I Photosensitizers June 11, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D5QO00684H, Research ArticleZhicheng Ban, Ning Ma, Hui Tang, Xiaoyun Ran, Qian Zhou, Yahui Zhang, Zhouyu Wang, Xiao-Qi YuEffectively improving the ability of electron transfer is the cornerstone of designing pure type I photosensitizers (PSs). At present, the bright strategies are to introduce the electron-rich structures to promote...The content of […]Zhicheng Ban
- A negatively curved carbonyl-bridged triphenylamine June 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00794A, Research ArticleLin Wan, Yude Ji, Zikang Ma, Chengguo Yan, Weifan Wang, Gang ZhangA negatively curved carbonyl-bridged triphenylamine containing a heptagonal ring was synthesized and further derivatized to generate compounds with different properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Lin Wan
- Tandem reductive alkylation of quinolines to functionalized tetrahydroquinolines enabled by HFIP June 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00519A, Research ArticleSiddhartha Kumar Senapati, Tapashi Das, Animesh DasHexafluoroisopropanol (HFIP)-mediated one-pot tandem reduction of quinolines to tetrahydroquinolines followed by reductive alkylation by the aldehyde has been demonstrated through H-bonding network-enabled substrate activation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Siddhartha Kumar Senapati
- Kinetic resolution of trifluoromethylated heterobenzhydrols via hydrogen-acceptor-free Ir-catalyzed heteroaryl-selective C–H silylation June 10, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D5QO00725A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryu Tadano, Takeshi Yasui, Yoshihiko YamamotoWe experimentally and computationally investigated the kinetic resolution of trifluoromethylated heterobenzhydrols, bearing both phenyl and thiophene rings, via heteroaryl-selective C–H silylation.To cite this article before page numbers […]Ryu Tadano
- One-pot C2-arylation and C4-acetoxylation of tryptophan derivatives via palladium-catalyzed tandem C–H activation June 25, 2025
