RSC – Org. Chem. Front. latest articles- A Persistent Concealed Non-Kekulé Nanographene: Synthesis and in-situ Characterization December 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02019G, Research ArticleMuhammad Imran, Lin Yang, Jinjiang Zhang, Yubin Fu, Zhen-Lin Qiu, Noel Israel, Evgenia Dmitrieva, Gianluca Serra, Andrea Lucotti, Matteo Tommasini, Ji Ma, Xinliang FengConcealed non-Kekulé (CNK) nanographenes have recently gained attention as promising non-Kekulé model systems due to their distinctive antiferromagnetic electronic spins, which offer potential applications […]Muhammad Imran
- Solvent-dependent fluorescence sensing of Cu2+, Hg2+, and CN‒ based on thiosemicarbazone-functionalized pillar[5]arene and its applications in actual water samples and molecular logic gates December 20, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02001D, Research ArticleMingkun Yang, Yan Chen, Suoluan Zhou, Chengnuo Hu, Jun Tong Zhang, Yunhan Yang, Li-Juan YangA novel solvent-dependent fluorescent probe P5T based onapillar[5]arene containing a thiosemicarbazone unit has been synthesized. This probe serves as a dual selective fluorescent probe, which can selectively detect Cu2+ and...The content of this […]Mingkun Yang
- Bipolarsterol A, a steroid with an unprecedented 6/5/6/5 carbon skeleton from the phytopathogenic fungus Bipolaris oryzae December 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02057J, Research ArticleMeijia Zheng, Xiaotian Zhang, Xinran Zhang, Yingjie Liu, Qin Li, Lidan Mao, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng ZhuBipolarsterols A−H (1−8), eight undescribed steroids were isolated from Bipolaris oryzae, along with nine known congeners. Their structures and absolute configurations were elucidated by comprehensive spectroscopic techniques, NMR […]Meijia Zheng
- Organocatalytic Enantioselective [2 + 2] Cycloadditions towards Chiral Fused -Trifluoromethyl Azetidines December 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01942C, Research ArticleSong Zhang, Xingjie Luo, Si-Qiang Fang, Jia-Hong Wu, Jianke Pan, Zhipeng Xu, Tianli WangAccess to relatively high energy azetidines in enantioenriched form via a function- and diversity-oriented approach is highly desired in the field of drug-discovery. Although the demands for α-trifluoromethyl azetidines with...The content of this RSS […]Song Zhang
- Visible-light-induced dehydrogenation of dihydroquinolinones via the combination of energy transfer and hydrogen atom transfers December 19, 2024Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO01902D, Research ArticleJin Feng, Hanguang Tang, Hao Guo, Aishun DingA visible-light-induced dehydrogenation of dihydroquinolinones was developed using photocatalyst thioxanthone (TX) and oxidant tert-butyl benzoperoxoate.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Jin Feng
- Palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of indoles with α-oxocarboxylic acids via C−H activation December 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02024C, Research ArticleLiwei Zhou, Pengyang Jing, Wenbo Deng, Shuyi Guo, Yun Liang, Yuan YangHerein, we report a novel palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of C2-tethered indoles with α-oxocarboxylic acids via C−H activation. In this reaction, dearomatization of C2-tethered indoles occurs via...The content of this RSS Feed (c) […]Liwei Zhou
- From conventional to dual Co/photoredox mediated reductive coupling of alkynes and alkenes December 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02143F, HighlightBalázs Tóth, Stephanie Grace Elizabeth Amos, Arjan Willem KleijMetal-catalyzed reductive coupling reactions between alkenes and alkynes are a long-standing tradition as a way to create complex unsaturated building blocks of value in organic synthesis ventures. Here, we review...The content of this RSS Feed (c) The Royal Society of […]Balázs Tóth
- Ball-milling and piezoelectric materials enabled radical trifluoromethylation of enamides and acrylamides December 19, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01911C, Research ArticleVitalii Solomin, Matthias Liard, Philippe Jubault, Thomas CastanheiroA mechanochemical radical direct C(sp2)-H trifluoromethylation of enamide derivatives was developed using Togni II reagent. Under a mechanochemical compression, application of 0.5 to 1.0 equivalent of piezoelectric materials enabled the...The content of this RSS Feed (c) The Royal Society of […]Vitalii Solomin
- Enantioselective Synthesis of α-Chiral Sulfonates through Palladium-Catalyzed Tsuji-Trost Sulfonylation with Sulfur Dioxide December 18, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01887G, Research ArticleXiaochun He, Fei Zhou, Qingqing Wang, Xiaohong Wang, Zhiqian Chang, Xuemei Zhang, Zhong Lianα-Chiral sulfonates have remained largely uncharted territory, primarily due to the intrinsic difficulties associated with achieving stereocontrol. In this study, we present an innovative three-component palladium-catalyzed asymmetric Tsuji-Trost sulfonylation protocol,...The content of this RSS […]Xiaochun He
- Synthesis of Biological Studies of 3-Trideuteromethylated Chromones and their Heteroatom Analogues December 18, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02081B, Research ArticleKaiyue Yang, Dongke Zhang, Ce Yang, Xueyan Yang, Jiaxin He, Haofeng Shi, Zichuan Liu, Yunfei DuThe bioactive trideuteromethylated chromones and their heteroatom analogues were synthesized via trideuteromethylation of chromones and their heteroatom analogues by utilizing Fenton's reagent system with d6-DMSO as the “CD3” source. Mechanistically,...The content of […]Kaiyue Yang
- Solvent-controlled C2/C3-regioselective ring-opening/coupling of aziridines with amines and CS2: synthesis of 2-aminoethyl dithiocarbamates December 18, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02148G, Research ArticleWenxue Li, Xueying Yang, Man Miao, Fengkai Sun, Hui Yuan, Xiaobing Lan, Jianqiang Yu, Jian Zhang, Zhenyu AnThis study presents a solvent-controlled C2/C3-regioselective ring-opening/coupling of aziridines with amines and CS2, yielding two distinct types of 2-aminoethyl dithiocarbamates without the need for additives or non-green activation strategy. Featuring...The […]Wenxue Li
- Acetic acid-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles under azide-free conditions December 18, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02118E, Research ArticleJiuling Li, Xinyu Jia, Qiangguo Yang, Jiakang Guo, Qianhui Ren, Taichen Liu, Kai Wei, Zheng-Hui KangAn environmental-friendly and safe method has been developed to synthesize 1,5-disubstituted 1,2,3-triazoles containing difluoromethyl fragments, which can be obtained from readily available 2,2-difluoroarylethylamines under azide-free conditions. The classic conversion mode...The content of […]Jiuling Li
- Synthesis of Cyclic Phosphonium-Borate Compounds through Reaction of Benzynes and Frustrated Lewis Pairs December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01852D, Research ArticlePei Xie, Fang Zhang, Zhihua Cai, Yating Zheng, Leifang Wu, Lin HeA practical method for the construction of stable zwitterionic phosphonium-borate compounds via trapping of benzynes by phosphine-borane frustrated Lewis pairs have been developed. A series of structurally diverse phosphonium-borate inner...The content of this RSS Feed (c) […]Pei Xie
- Tandem Synthesis of Enantioenriched Spirolactones via One-Pot Heck-Matsuda Reactions Directly from Nitroarenes December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01979B, Research ArticleTomaz Chorro, Clemens Kaussler, Julia V. Kolodiazhnaia, Frank Jensen, Troels Skrydstrup, Carlos Roque CorreiaWe report herein a novel, efficient, and expeditious approach for enantioselective intramolecular carbonylative Heck-Matsuda reaction, employing highly accessible, stable, and cost-effective nitroarenes as masked electrophiles. This tandem process combines the...The content of this RSS […]Tomaz Chorro
- Synthesis of Pyrrolo[1,2-a]quinoxalines via an Electrochemical C(sp3)-H Functionalization December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01981D, Research ArticleSijie Peng, Tong Li, Kai Li, Qi Sun, Zhiyong WangAn efficient iodine-mediated electrochemical C(sp3)-H cyclization was developed under mild conditions. A variety of functionalized quinoxalines can be obtained with good to excellent yields by virtue of this method. The...The content of this RSS Feed (c) The Royal […]Sijie Peng
- Access to Fluorinated Dienes through Hydrofluorination of 2-En-4-ynoates December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02049A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yue Xia, Aaron D. Charlack, Rui Guo, Nicholas W. Wade, Yiming WangThe hydrofluorination of enynes has been developed for the synthesis of fluorinated dienes. Using a pyridinium tetrafluoroborate salt that is easily […]Yue Xia
- Ag-Catalyzed and Difluorocarbene-Promoted Amide-Ylide Rearrangement: Synthesis of 3-Salicyloylpyridines December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01961J, Research ArticleXu Yuan, Tong Zhou, Qiaoqiao Wang, Yu Chen, Xiaohong Cheng, Yi JinHerein, we report an Ag-catalyzed and difluorocarbene-promoted amide-ylide rearrangement strategy. This strategy utilizes an unconventional transformation between difluorocarbene and amide functionalities to successfully synthesize 3-salicyloylpyridines. Preliminary mechanistic studies suggest that...The content of this RSS Feed (c) […]Xu Yuan
- Recent advances of calcium(II) triflimide in organic synthesis December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02164A, Review ArticleHaoran Li, Minyao Kuang, Yuwei Liu, Wei Yi, Shengdong WangEnvironmentally benign calcium(II) triflimide has emerged as a sustainable substitute for transition-metal catalysts, rare-earth metals, and strong Brønsted acids in promoting organic synthesis, thereby attracting considerable attention. Recently, elegant methodologies...The content of this RSS Feed (c) The Royal […]Haoran Li
- Ag(I)-linked Bis-calix[4]pyrrole Molecular Capsule and its Selective Recognition of Fluoride Anion December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02177K, Research ArticleXiaolong Chen, Zhiye Zheng, Shunfeng Peng, Ying Guo, Ying Gao, Chenxing Guo, Jonathan L. Sessler, Hong-Yu WangA well-defined “four-wall” capsule (3) was constructed based on the coordination-driven self-assembly of a tetratopic pyridine-functionalized calix[4]pyrrole cavitand with four stabilizing pyridine···Ag+···pyridine coordination bonds in N,N-dimethylformamide (DMF). Capsule was 3...The content […]Xiaolong Chen
- In situ generated aza-π-allylpalladium zwitterions as nucleophilic triggers for enantioselective [4 + 2] cycloaddition with electron-deficient alkenes toward functionalized chiral piperidines December 17, 2024Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02058H, Research ArticleHan-Yang Zhong, Hong-Wei Xiao, Ji-Hong Liu, Zhen-Zhen Ge, Jian-Qiang Zhao, Ming-Qiang Zhou, Wei-Cheng YuanAza-π-allylpalladium zwitterions, in situ generated from Pd-catalyzed decarboxylation of methylene cyclic carbamates, have so far been reported only as electrophilic triggers for promoting various asymmetric reactions. Herein, for the first...The content of this RSS […]Han-Yang Zhong
- A Persistent Concealed Non-Kekulé Nanographene: Synthesis and in-situ Characterization December 20, 2024
