RSC – Org. Chem. Front. latest articles- Divergent application of 5-amino-isoxazoles for the construction of nitrogen heterocycles via the hydride transfer strategy January 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02059F, Research ArticleMengzhe Pan, Feng-Wei Guo, Xinjie Sun, Jie Zhang, Wei Lu, Lubin Xu, Fangzhi Hu, Shuai-Shuai LiThe hydride transfer-enabled divergent application of 5-amino-isoxazoles for the controllable construction of diverse tetrahydroquinolines and tetrahydroquinazolines was disclosed with the employment of different Lewis acids.To cite this article before page numbers are […]Mengzhe Pan
- Redox reaction between N-heterocyclic carbenes and sulfonates: insights into unproductive catalytic paths January 17, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02196G, Research ArticleJia Song, Wei Wang, Guanjie Wang, Wen-Xin LvThis study provides new insights and understanding of the possible deactivation pathways of NHC catalysts via uncommon redox processes of NHC catalysts with sulfonyl compounds, which should inspire future catalyst design and reaction development.To cite this article before page numbers […]Jia Song
- Diverse C(sp3)–H functionalizations through electrochemical benzylic oxygenation January 16, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02022G, Research ArticleYan He, Tian-Sheng Chen, Xuesen Fan, Hai-Chao XuReported herein is a transition metal catalyst- and oxidant-free platform for diversity-oriented benzylic C–H functionalization. The process involves electrochemical C(sp3)–H oxygenation followed by elimination/substitution with diverse nucleophiles.To cite this article before page numbers are assigned, use the DOI form of […]Yan He
- Synthesis of Antimicrobial Active 9,10-Phenanthrenequinones by Carbene Organocatalytic Tandem Reactions January 15, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02193B, Research ArticleYaoluo Hu, Ya Hong, Yuting Zheng, Yi Huang, Jixiang Chen, Xingxing WuPhenanthrenequinones (PQs) are extensively studied in synthetic chemistry and materials science, exhibiting noteworthy biological activities essential for drug discovery. The development of efficient synthetic methods for PQ preparation has thus...The content of this RSS Feed (c) […]Yaoluo Hu
- Recent Advances in Catalytic Asymmetric Reactions of Morita–Baylis–Hillman adducts January 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02212B, Review ArticleXu-Hong Duan, Hui-Ru Du, Yong-Xing SongMorita-Baylis-Hillman adducts has become an efficient synthon for the construction of C-C or C-heteroatom bonds, and has been widely used in the asymmetric synthesis of various new optically pure compounds....The content of this RSS Feed (c) The Royal Society of ChemistryXu-Hong Duan
- Highly Selective Visible-Light-Induced Cascade Cyclization of Vinyl Sulfoxonium Ylides with Azides: A Novel Synthetic Approach to Trisubstituted Furans January 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02195A, Research ArticleJia-Huan Cui, Mei Tan, Jun Zhang, Yan He, Xingguang Li, Pei-Nian LiuA simple protocol for the synthesis of trisubstituted furans via visible-light-driven regioselective cascade cyclization of vinyl sulfoxonium ylides with azides has been achieved. The reaction proceeds through the formation of...The content of this RSS Feed (c) […]Jia-Huan Cui
- Constructing less-conjugated olefins via unusual regioselective hydrogen atom transfer from acetals January 14, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02099E, Research ArticleZhaoshan Wang, Huiying Liu, Tian-Tian Liu, Qixiang Wang, Youhao Wei, Xiaoguang Bao, Xinxin WuUtilizing a regioselective hydrogen atom transfer (RHAT) strategy, this study demonstrates a triple RHAT process accompanied by C–O bond homolysis to generate unusual less-conjugated or contra-thermodynamic olefins, a transformation rarely...The content of this RSS […]Zhaoshan Wang
- Recent advances in enantioselective construction of C–N bonds involving radical intermediates January 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02268H, Review ArticleJiaqiong Sun, Guangfan Zheng, Ge Zhang, Yan Li, Qian ZhangThis review offers a comprehensive overview of recent advancements in the asymmetric construction of C–N bonds involving radical intermediates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]Jiaqiong Sun
- Influencing optical and charge transport properties by controlling the molecular interactions of merocyanine thin films January 14, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02088J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lukas Böhner, Philipp Weitkamp, Thorsten Limböck, Nora Gildemeister, Daniele Fazzi, Manuela Schiek, Ruth Bruker, Dirk Hertel, Roland Schäfer, Klas Lindfors, Klaus MeerholzCombination of optical and transport measurements on merocyanine films indicates an […]Lukas Böhner
- Visible-light-driven anion relay chemistry (ARC): construction of fully substituted pyrazoles January 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02072C, Research ArticleGuodan Lu, Tao Zhang, Xionglve Cheng, Kehan Qian, Yong Wang, Xiaobing WanAn unprecedented visible-light-driven anion relay chemistry (ARC) strategy for constructing fully substituted pyrazoles under mild conditions was well established.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Guodan Lu
- Three-step alkylaminomethylative α,β-difunctionalization of enones January 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02259A, Research ArticleEvgeny M. Buev, Vladimir Moshkin, Vyacheslav SosnovskikhAminomethylation of alkenes is a convenient methodology for the synthesis of aliphatic amines. This direction encompasses various methods, mainly allowing functionalization of the C=C bond of the molecule with the...The content of this RSS Feed (c) The Royal Society of ChemistryEvgeny M. Buev
- Photocatalyzed anti-Markovnikov addition of carboxylic acids to alkenes: ionic mechanism under radical conditions January 13, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02280G, Research ArticleDmitry L Lipilin, Mikhail O Zubkov, Mikhail Kosobokov , Alexander DilmanSince the advent of photocatalysis, the radical addition to alkenes has become one of the most fruitful processes for building up the molecular complexity. Herein we describe a novel approach...The content of this RSS Feed (c) The […]Dmitry L Lipilin
- Six pairs of α-pyrone meroterpenoid dimers from Hypericum monogynum with anti-neuroinflammatory activity January 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02179G, Research ArticleJun Jin, Yan-Ling Li, Li-Hua Chen, Feng Zhang, Xin-Yu Zuo, Yan-Rong Zeng, Jue Yang, Xiao-Jiang Hao, Chun-Mao YuanHypericumonates A–C, the first α-pyrone meroterpenoid dimers with two motifs (a 6/6/4-6/6 ring system) connected via C-8–C-9, were isolated from Hypericum monogynum. (+)-1 exhibited good anti-neuroinflammatory activity.To cite this article […]Jun Jin
- Benzofuranone-based spiropyrans: synthesis, temperature-dependent photochromic properties, and DFT calculations January 13, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02123A, Research ArticleXincheng Zhou, Zhichao Chang, Yongchun Hu, Jianming Zhong, Jiaying Liao, Chunying Rong, Wang ZhouThe synthesis of benzofuranone-based spiropyrans containing a thiophene, benzothiophene, or indole moiety, their diverse temperature-dependent photochromic properties, and DFT rationalization.To cite this article before page numbers are assigned, use the DOI form of citation […]Xincheng Zhou
- Synthesis of a cross-chain bridging cryptand January 10, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02330G, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Takafumi Yashima, Ryoga Hori, Taisei Maruyama, Kohta Nakashima, Hiroki Fujihara , Masaya Naito, Shinobu Miyagawa, Yuji TokunagaWe present two methodologies for synthesizing cross–chain bridging cryptand 1 that incorporates tri- and tetra(ethylene glycol) […]Takafumi Yashima
- Progress in Catalytic Enantioselective Construction of Difluoroalkylated Stereogenic Center January 10, 2025Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO02309A, Review ArticleLi-Juan Tang, Yongshun Wen, Hong-Xian Jin, Wenjun Luo, Lipeng Long, Jiayi Shen, Haiqing Luo, Daohong YuMolecules bearing the difluoroalkyl groups were very important in pharmaceuticals, argrochemicals and materials. In recent years, more and more attentions were paid to develop novel synthetic method for constructing compounds...The content of […]Li-Juan Tang
- Computational study on Pd-catalyzed ipso,meta-dimethylation of ortho-substituted iodoarenes: mechanisms and the role of the base January 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02168A, Research ArticleKang Lv, Yihang Zhou, Zitong Meng, Jing Zhang, Tao LiuThe detailed mechanisms of Pd-catalyzed ipso,meta-dimethylation reactions of ortho-substituted iodoarenes and the origin of base-controlled chemoselectivity were investigated by DFT calculations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]Kang Lv
- Access to (bridged) bicyclic ureas through azocarboxamide-enabled enantioselective 1,2-diamination of α-branched cyclic ketones January 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02318H, Research ArticleLi Li, Yuan-Yang Li, Bei-Bei Li, Linlin Shi, Beiling Gao, Guang-Jian MeiReported here is the azocarboxamide-enabled enantioselective 1,2-diamination of α-branched cyclic ketones. A wide range of fused and bridged bicyclic ureas were prepared in good yield with excellent enantioselectivity.To cite this article before page numbers are assigned, […]Li Li
- Synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines through a sequential multicomponent assembly, oxygenation and 6πe electrocyclization reactions January 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02067G, Research ArticleAnil Rangnath Pawar, Sabina Yashmin, Abu Taleb KhanA single-step synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines is disclosed using a MCR and cascade reactions. Here, DMSO reacts for regioselective ‘O’ transposition and assists in situ 6πe electrocyclization and aromatization reactions.To cite this article before page numbers are assigned, use the DOI […]Anil Rangnath Pawar
- The Giese reaction of alkyl bromides using amine carboxyboranes January 9, 2025Org. Chem. Front., 2025, Advance ArticleDOI: 10.1039/D4QO02325K, Research ArticleChanghee Park, Seyun Gi, Seongkyeong Yoon, Seong Jung Kwon, Sunggi LeeThe Giese reaction of alkyl bromides was achieved using amine carboxyboranes as ligated boryl radical precursors. Furthermore, ligated boryl radicals were utilized to establish carbon–boron bonds.To cite this article before page numbers are assigned, use the DOI […]Changhee Park
- Divergent application of 5-amino-isoxazoles for the construction of nitrogen heterocycles via the hydride transfer strategy January 17, 2025
