RSC – RSC Chem. Biol. latest articles- Integration of Palladium-Catalyzed C-N Coupling into Self-Encoded Libraries for Accelerated Hit Discovery March 3, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00303B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Pomplun, Edith van der Nol, Zhenshuo Luo, Qing Qing Gao, Nils A Haupt, Sebastian BoeckerAffinity screenings with encoded libraries are transformative tools for rapid hit discovery from vast compound collections. Yet the […]Sebastian Pomplun
- Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection February 26, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00242G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isabella E Pellizzari-Delano, Trinity H Tooley, Debanjana Mondal, Keya Jani, Carla E Gallardo-Flores, Che C ColpittsBroad spectrum antivirals are critical to respond rapidly to the threat posed by newly emerging RNA viruses. One […]Isabella E Pellizzari-Delano
- Discovery of natural products that modulate signaling in patient-derived cells February 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00203F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Joseph A. Balsamo, Hannah L. Thirman, Kathryn E. Penton, Jordan T. Froese, Benjamin J. Reisman, Sierra M. Lima, Madeline J. Grider-Hayes, Chad R. Potts, Jonathan M. Irish, P. Brent Ferrell, Brian O. BachmannMany […]Joseph A. Balsamo
- Structure and characterisation of CMP-Kdn synthetase from the haptophyte microalgae Prymnesium parvum February 25, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00285K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Claire Morley, Alexandra J. Munro-Clark, Ben A. Wagstaff, Irina Ivanova, Evgenia Dubinskaya, Ava Rostock, Mary Ortmayer, Colin W. Levy, Robert A. FieldStructural characterisation of a Kdn specific sialic acid synthetase, which can be […]Claire Morley
- Bifunctional glycolipids targeting TLR4‧MD-2 and short pentraxins February 24, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00324E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Daniele Zucchetta, Lena Nuschy, Simon Gumpelmair, Peter Steinberger, Iain B. H. Wilson, Holger Heine, Alla ZamyatinaInnate immune detection of pathogen- and danger-associated molecular patterns (PAMPs/DAMPs) centres on pattern-recognition receptors, with the TLR4/MD-2 complex […]Daniele Zucchetta
- Folded-State Compatibility and Unfolded-State Constraint Govern Staple-Based Stabilization: Guidelines from a Coiled-Coil Model February 24, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00326A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samantha C. Hatfield, Alexa N. Mattingley, Kayla K. Sujeta, Logan D. Humphrey, Taylor Crook, Hiram Aranda, Christian H. Freckleton, Joseph V. Clayson, Chase Renstrom, Joshua L. PricePeptide stapling has emerged as a powerful […]Samantha C. Hatfield
- Fluorescent Cationic Fluorinated Oxazoliniums for Cysteine Bioconjugation via S N Ar Reaction February 20, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00289C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Karen Ka-Yan Kung, Yosephine Tania Limanto, Ajcharapan Tantipanjaporn, Jie-Ren Deng, Lai- Yi Tsang, Man Kin WongUsing cationic fluorinated oxazolinium compounds, fluorescent cysteine-selective SNAr bioconjugation proceeds under mild conditions, resulting in fluorescent-labelled peptides and […]Karen Ka-Yan Kung
- Development of a transcription factor-based biosensor strain for reporting α-terpineol production via the alcohol-dependent hemiterpene pathway in Escherichia coli February 18, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00310E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Catherine A. Odhiambo, Isaac A. Ali, Gavin J. WilliamsDevelopment of a genetically-encoded biosensor enabled reporting production of α-terpineol in an engineered E. coli strain.To cite this article before page numbers are assigned, use […]Catherine A. Odhiambo
- ILLUMINATING MICROTUBULAR FUNCTION WITH SMALL MOLECULES: PAST, PRESENT AND FUTURE OF FLUORESCENT TUBULIN-BINDING PROBES February 11, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00321K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rebeca París-Ogáyar, Daniel Lucena-Agell, Karl-Heinz Altmann, Valle Palomo, J. Fernando DiazDeveloping tools for the real-time visualization of tubulin, microtubules, and their dynamics has been essential for studying key cellular processes such as […]Rebeca París-Ogáyar
- Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures February 10, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00302D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alva Abrahamsson, Sakina Khwaja, Andreas Berner, Rabindra Nath Das, Koit Aasumets, Namrata Chaudhari, Sjoerd Wanrooij, Erik ChorellG4-ligands with varying chemical profiles were incorporated into G4-ligand conjugated oligonucleotides (GL-Os) and evaluated for G-quadruplex binding […]Alva Abrahamsson
- Integration of Palladium-Catalyzed C-N Coupling into Self-Encoded Libraries for Accelerated Hit Discovery March 3, 2026
