RSC – RSC Chem. Biol. latest articles- ILLUMINATING MICROTUBULAR FUNCTION WITH SMALL MOLECULES: PAST, PRESENT AND FUTURE OF FLUORESCENT TUBULIN-BINDING PROBES February 11, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00321K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rebeca París-Ogáyar, Daniel Lucena-Agell, Karl-Heinz Altmann, Valle Palomo, J. Fernando DiazDeveloping tools for the real-time visualization of tubulin, microtubules, and their dynamics has been essential for studying key cellular processes such as […]Rebeca París-Ogáyar
- Tuning Potency for Precision: The Role of the G4-Ligand in G4-Ligand-Conjugated Oligonucleotides Targeting Individual G-Quadruplex DNA Structures February 10, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00302D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alva Abrahamsson, Sakina Khwaja, Andreas Berner, rabindra Das, Koit Aasumets, Namrata Chaudhari, Sjoerd Wanrooij, Erik ChorellThe non-B DNA secondary structure known as G-quadruplex (G4) DNA can form in gene-regulatory regions of the human […]Alva Abrahamsson
- Covalent targeting of PSMD14 by Eupalinolide B induces oncoprotein degradation and apoptosis in acute promyelocytic leukemia cells February 4, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00197H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Zheng Chu, Liting Xu, Honglin Chen, Tianyun Fan, Xueqian Hu, Yin Kwan Wong, Qiaoli Shi, Junzhe Zhang, Chengchao Xu, Jigang Wang, Huan TangEupalinolide B covalently targets PSMD14, inhibiting its deubiquitinase activity. This leads […]Zheng Chu
- High-throughput assay for measuring target occupancy of covalent compounds: a case study with MK2 February 4, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00224A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Julian L. Wong, Mari Manuia, Sandra Gao, Natacha Stoehr, Theresa Boersig, Krystine Vuong, Tao Jiang, Jian Cao, Yong Jia, C. C. King, John Joslin, Leslie Ofori, Jon Loren, Zuni I. BassiTwo complementary, plate-based […]Julian L. Wong
- Enabling the synthesis of multi-payload thio-antibody conjugates through the use of pyridazinediones, p-anisidine derivatives and various click chemistries February 3, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00018E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cliona McMahon, Christophe Queval, Ioanna Thanasi, Dawn Lau, Michael Howell, Ning Wang, Maximillian Lee, Josephine S Gaynord, James R. Baker, Vijay ChudasamaIn recent years, antibody-drug conjugates (ADCs) have emerged as a very promising […]Cliona McMahon
- Optical Control of Cas9 Activity through Visible-Light Cleavable crRNAs January 29, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00294J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vanessa Hanff, Stepan Jerabek, Kim A Langer, Robin Klimek, Janik Kaufmann, Jimin Kim, Dieter Egli, Alexander HeckelIn this work, we present several visible-light cleavable crRNAs targeting two different genes for regulating Cas9 activity. […]Vanessa Hanff
- Repression of bacterial gene expression by antivitamin B12 binding to a cobalamin riboswitch January 26, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00308C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Florian J. Widner, Naziyat I. Khan, Evelyne Deery, Martin J. Warren, Michiko E. Taga, Bernhard KräutlerCoenzyme B12 and its Rh-analogue, the antivitamin B12 AdoRhbl, bind both the btuB-riboswitch with exceptional affinity and inhibit […]Florian J. Widner
- DNA-targeting Invader probes: discovery, principles and applications January 23, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00286A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Patrick J. Hrdlicka, Michaela E. EverlyInvader are double-stranded oligonucleotide probes with specific zippers of intercalator-functionalized nucleotides that enable efficient and highly specific recognition of complementary DNA regions via a strand-invasion mechanism.To cite […]Patrick J. Hrdlicka
- Does sod1 encode a molecular clock? Mutations that mimic asparagine deamidation inhibit heterodimerization with ALS-mutant SOD1 January 23, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00225G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mayte Gonzalez, Travis J. Lato, Emily A. Alonzo, Soeun Park, Morgan T. Green, Natalia Soto-Rodriguez, Bryan F. ShawThe self-exchange of subunits by protein homodimers is a common protein–protein interaction in vivo.To cite this […]Mayte Gonzalez
- Recent developments in the delivery of peptide nucleic acids (PNAs) January 22, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00301F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Srijani Sarkar, Niren MurthyPNAs have strong therapeutic potential but poor cellular uptake. This graphic highlights approaches like backbone modification, transporter conjugation, and nanoparticle encapsulation that have improved delivery and enhanced antisense activity.To […]Srijani Sarkar
- ILLUMINATING MICROTUBULAR FUNCTION WITH SMALL MOLECULES: PAST, PRESENT AND FUTURE OF FLUORESCENT TUBULIN-BINDING PROBES February 11, 2026
