RSC – RSC Chem. Biol. latest articles- Siderophore-based Targeted Antibody Recruitment for Promoting Immune Responses towards Gram-negative Pathogens January 16, 2025RSC Chem. Biol., 2024, Accepted ManuscriptDOI: 10.1039/D4CB00293H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Seungwoo Kim, Ho-Sung Park, Do Young Kim, Hyunhi Joh, Jiseok Oh, Dong Ho Kim, Min Ju Kang, Chui Hee Choi, Hak Joong KimAntibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing […]Seungwoo Kim
- Macrocyclic peptides as a new class of targeted protein degraders January 15, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00199K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xuefei Jing, Joel P. Mackay, Toby PassiouraTargeted degraders and cyclic peptides are both emerging therapeutic modalities. This review describes recent efforts to combine these approaches, to generate cyclic peptidic targeted degraders with […]Xuefei Jing
- Raman Active Diyne-Girder Conformationally Constrained p53 Stapled Peptides Bind to MDM2 for Visualisation Without Fluorophores January 15, 2025RSC Chem. Biol., 2024, Accepted ManuscriptDOI: 10.1039/D4CB00288A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Danielle Morgan, Laura McDougall, Astrid Knuhtsen, Lori Buetow, Craig F Steven, Oscar Shepperson, Danny T Huang, Alison N Hulme, Andrew George JamiesonPeptide stapling is an effective strategy to stabilise α-helical peptides, enhancing their […]Danielle Morgan
- Uncovering the substrate of olefin synthase loading domains in cyanobacteria Picosynechococcus sp. strain PCC 7002 January 14, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00234B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Audrey E. Yñigez-Gutierrez, Erin Conley, Michael G. Thomas, Brian F. PflegerWe report the heterologous expression of two olefin synthases in PCC 7002 to generate shorter chain α-olefins. Genetic deletions show that membrane-liberated fatty […]Audrey E. Yñigez-Gutierrez
- Using environment-sensitive tetramethylated thiophene-BODIPY fluorophores in DNA probes for studying effector-induced conformational changes of protein–DNA complexes January 2, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00260A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Markéta Šoltysová, Pedro Güixens-Gallardo, Irena Sieglová, Anna Soldánová, Veronika Krejčiříková, Milan Fábry, Jiří Brynda, Petro Khoroshyy, Michal Hocek, Pavlína ŘezáčováUsing fluorophore-linked probes, we revealed conformational changes affecting protein–DNA affinity that were undetectable using […]Markéta Šoltysová
- An expanded substrate scope for cross-chiral ligation enables efficient synthesis of long L-RNAs December 26, 2024RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00253A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xuan Han, Jonathan T. SczepanskiThis work describes a straightforward strategy for assembling long L-RNAs via the joining of two or more shorter fragments using cross-chiral ligase ribozymes together with new substrate activation chemistry.To […]Xuan Han
- The molecular features of non-peptidic nucleophilic substrates and acceptor proteins determine the efficiency of sortagging December 26, 2024RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00246F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tetiana Bondarchuk, Elena Zhuravel, Oleh Shyshlyk, Mykhaylo O. Debelyy, Oleksandr Pokholenko, Diana Vaskiv, Alla Pogribna, Mariana Kuznietsova, Yevhenii Hrynyshyn, Oleksandr Nedialko, Volodymyr Brovarets, Sergey A. ZozulyaInvestigation of the influence of the structural and […]Tetiana Bondarchuk
- A one-step route for the conversion of Cd waste into CdS quantum dots by Acidithiobacillus sp. via unique biosynthesis pathways December 20, 2024RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00195H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiao-Ju Li, Tian-Qi Wang, Lu Qi, Feng-Wei Li, Yong-Zhen Xia, Bin-Jin, Cheng-Jia Zhang, Lin-Xu Chen, Jian-Qun LinAcidithiobacillus sp. serves as biological factories for the synthesis of CdS quantum dots by directly using its bioleaching […]Xiao-Ju Li
- Non-enzymatic posttranslational protein modifications in protein aggregation and neurodegenerative diseases December 19, 2024RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00221K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tim Baldensperger, Miriam Preissler, Christian F. W. BeckerIn this review we summarize the known non-enzymatic posttranslational modifications (nPTMs) of proteins involved in neurodegeneration and discuss illustrative examples of such nPTMs studied using […]Tim Baldensperger
- Unveiling the promise of peptide nucleic acids as functional linkers for an RNA imaging platform December 19, 2024RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00274A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aleksandra J. Wierzba, Erin M. Richards, Shelby R. Lennon, Robert T. Batey, Amy E. PalmerIncorporating a PNA linker into an RNA imaging platform yielded significant improvements in probe affinity and specificity through a […]Aleksandra J. Wierzba
- Siderophore-based Targeted Antibody Recruitment for Promoting Immune Responses towards Gram-negative Pathogens January 16, 2025
