RSC – RSC Chem. Biol. latest articles- Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders October 29, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00125K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kohei Tsuji, Xueyuan Huang, Maho Miyamoto, Sayaka Sukegawa, Hidetomo Yokoo, Hiroaki Takeuchi, Yosuke Demizu, Hirokazu TamamuraAn HIV-1 accessory protein Vpr-derived peptide functions as an E3 ligase ligand, and this peptide-containing molecules successfully degraded […]Kohei Tsuji
- Investigating the Utilization Mechanism and Kinetics of Sialic Acid Mimetics in Mammalian Cell Lines October 29, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00193E, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Eline Visser, Daniël L.A.H. Hornikx, Moritz Rahm, Oezden Oeztuerk, Venetia Psomiadou, Matteo Calzari, Celine Mennen, Sam Moons, Martin Jaeger, Dirk Lefeber, Christian Büll, Thomas BoltjeSialic acid mimetics (SAMs) are chemically modified derivatives of […]Eline Visser
- Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1 October 28, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D4CB00323C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Emily C. Hank, Nicholas D'Arcy-Evans, Emma Rose Scaletti, Carlos Benítez-Buelga, Olov Wallner, Florian Ortis, Kaixin Zhou, Liuzhen Meng, Alicia del Prado, Patricia Calvo, Ingrid Almlöf, Elisee Wiita, Karen Nierlin, Sara Kosenina, Andreas Krämer, […]Emily C. Hank
- Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2 October 28, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00177C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cassandra R Kennedy, Katherine McPhie, Aini Vuorinen, Jane Dudley-Fraser, Diego Esposito, Sarah L Maslen, William McCarthy, Jonathan Pettinger, J. Mark Skehel, Jacob T. Bush, David House, Katrin RittingerAs the global fight against antimicrobial […]Cassandra R Kennedy
- Phage blocker: Discovery of a novel bacteriophage antiviral for phageome modulation October 27, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00120J, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Konstantin Plöchl, Thomas BöttcherBacteriophages have emerged as important factors in human health and disease, with elevated phage levels linked to exacerbated inflammatory bowel disease, type 2 diabetes and poor outcomes in skin and...The […]Konstantin Plöchl
- A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition October 23, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00233H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Paige A. Barta, Leopold Garnar-Wortzel, Timothy R. Bishop, Rachel E. Hayward, Lauren M. Hargis, James B. Shaum, Hui Si Kwok, Brian B. Liau, Benjamin F. Cravatt, Michael A. ErbTranscriptional regulatory proteins are frequent […]Paige A. Barta
- Screening and machine learning-based prediction of translation-enhancing peptides that reduce ribosomal stalling in Escherichia coli October 21, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00199D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Teruyo Ojima-Kato, Gentaro Yokoyama, Hideo Nakano, Michiaki Hamada, Chie MotonoTranslation-enhancing peptides (TEPs) that reduce ribosomal stallling in Escherichia coli were identified through comprehensive screening, and their activity was predicted using a machine learning […]Teruyo Ojima-Kato
- Native mass spectrometry of membrane proteins reconstituted in peptidiscs October 21, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00236B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Agrima Deedwania, Yi Wang, Carol V. Robinson, Jani R. BollaMembrane proteins and lipids are essential for a wide range of cellular processes, making their structural characterisation essential for understanding biological function.To cite this […]Agrima Deedwania
- Programmable synthesis of alkaloidal frameworks integrating Michael acceptor generates covalent probes for targeting POLE3 in HBV replication October 20, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00268K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nobuto Kaneko, Misao Himeno, Yuhi Kobayashi, Ryo Tanifuji, Hiroki Kubota, Haruki Mizoguchi, Makoto Muroi, Takehiro Suzuki, Masaya Sugiyama, Naoshi Dohmae, Hiroyuki Osada, Taketomo Kido, Atsushi Miyajima, Hiroki OguriA one-pot programmable synthesis of six […]Nobuto Kaneko
- Affinity-based protein profiling of the antiviral natural product nanchangmycin October 20, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00126A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Santiago Leiva, Chloé Freyermuth, Stéphane Claverol, Daniele Mantione, Emmanuelle ThinonAn affinity-based probe of the natural product nanchangmycin revealed a new mechanism by which this compound inhibits Zika virus infection.To cite this article before […]Santiago Leiva
- Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders October 29, 2025
