RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• A trifunctional probe for generation of fluorogenic glycan-photocrosslinker conjugates. September 16, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00206K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brandon Vreulz, Daphnée de Crozals, Samy CecioniInteractions between cell surface glycans and lectins mediate vital biological processes, yet their characterization is hindered by the low affinity of these binding events. While photoaffinity labeling […]
  Brandon Vreulz
• Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays September 10, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00189G, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jason L. Heier, Dylan J. Boselli, Laurie L. ParkerA novel substrate was developed providing a high-throughput-compatible lanthanide luminescence assay that is selective for CDK5 over closely related CDK2.To cite this article before page […]
  Jason L. Heier
• A Cell-based High Throughput Screening by a Target-NanoLuc Fusion Construct to Identify Molecular Glue Degraders of c-Myc Oncoprotein September 7, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00093A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Muyu Xu, Jinying Qiu, Lin Tan, Jiayu Xu, Yi Wang, Wenyue Kong, Hongda Liao, Anran Chen, Xiaolan Chen, Jiying Zhang, Cookson K. C. Chiu, Meiying Zhang, Yingying Tian, Caohui Li, Biao Ma, Leiming […]
  Muyu Xu
• Deciphering protein long-chain S-acylation using mass spectrometry proteomics strategies September 7, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00146C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anneroos E. Nederstigt, Samiksha Sardana, Marc P. BaggelaarDeciphering protein long-chain S-acylation using mass spectrometry proteomics strategies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]
  Anneroos E. Nederstigt
• Sources of mismeasurement of RNA knockdown by DNAzymes and XNAzymes September 7, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00182J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria J. Donde, Alicia Montulet, Alexander I. TaylorNucleic acid catalysts can carry over into cellular RNA preparations following transfection, causing false positive and false negative knockdown measurements.To cite this article before page numbers […]
  Maria J. Donde
• Photoresponsive molecular tweezers modulate Taspase 1 activity September 4, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00069F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Antonio L. Figueroa Bietti, Alisa-Maite A. Kauth, Katrin Hommel, Mike Blueggel, Laurenz Mohr, Felix C. Niemeyer, Christine Beuck, Peter Bayer, Shirley K. Knauer, Bart Jan Ravoo, Thomas Schrader“Claws Out!”: Molecular tweezers equipped with […]
  Antonio L. Figueroa Bietti
• 19 F NMR-tags for peptidyl prolyl conformation analysis September 3, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00118H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.George S. M. Hanson, Faidra Batsaki, Teagan L. Myerscough, Kristin Piché, Ariel Louwrier, Christopher R. CoxonWe evaluate fluorinated reagents for tagging cysteine in proline-containing peptides and use 19F NMR to measure %cis-Pro. One […]
  George S. M. Hanson
• Biosynthesis of sydonol reveals a new bisabolene cyclase and an unusual P450 aromatase September 3, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00213C, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Peiyu Lu, Ling LiuThe sydonol biosynthetic pathway was elucidated, featuring two novel enzymatic reactions: a bisabolene cyclase (Syd1) mediating 1,5-proton transfer and 1,7-hydride shift, and an unusual P450 (Syd2) catalyzing bisabolene aromatization.To cite […]
  Peiyu Lu
• Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism August 31, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00169B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nan Zhang, Kah Chee Pow, Lanfang Chen, Quan HaoIn this paper, the structures of six different states (from pre-NAD+ binding to intermediate I) during the SIRT2 deacylase reaction and two catalytically essential mutants […]
  Nan Zhang
• Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure August 31, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00116A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Erdinc SezginLabeling the plasma membrane is challenging due to probe internalization, photobleaching, and signal loss. We compared lipid-based probes and identified a superior one that efficiently labels membranes in live, fixed, and permeabilized […]
  Erdinc Sezgin