RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria August 25, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00092K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Montserrat Mora-Ochomogo, Mitchell Jeffs, Josephine L. Liu, Christopher T LohansThe use of β-lactam antibiotics is threatened by antibiotic resistant bacteria that produce β-lactamases. These enzymes not only protect the bacteria that produce them […]
  Montserrat Mora-Ochomogo
• Reductively Activated CPP-PROTAC Nanocomplexes Enhance Target Degradation via Efficient Cellular Uptake August 24, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00196J, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maho Miyamoto, Kosuke Saito, Hidetomo Yokoo, Yosuke DemizuWe developed a nanoparticle based on a cell-penetrating peptide-PROTAC conjugate with a disulfide linker, MZ1-R9, and dextran sulfate, enhancing cellular uptake and BRD4 degradation. This delivery […]
  Maho Miyamoto
• Peptide nucleic acids in parallel orientation form invasion complexes with double-stranded DNA August 20, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00172B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Masanari Shibata, Hiroshi Sugimoto, Masaki Hibino, Osami Shoji, Yuichiro AibaPeptide nucleic acid (PNA) is a unique class of synthetic nucleic acids with a pseudo-peptide backbone, known for its high nucleic acid recognition capability […]
  Masanari Shibata
• Data-driven chemistry for predicting catalytic activity of nucleic acid enzymes using AI August 20, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00105F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shuntaro Takahashi, Michiaki Hamada, Hisae Tateishi-Karimata, Naoki SugimotoNucleic acids (NA), namely DNA and RNA, dynamically fold and unfold to perform their functions in cells. Functional NAs include NA enzymes, such as ribozymes […]
  Shuntaro Takahashi
• Differential Melting Voltage by Tandem-Trapped Ion Mobility Spectrometry: Glycan Structure Influences Glycoprotein Stability August 19, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00127G, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mengqi Chai, Christian Bleiholder, Fanny C. LiuProfiling the full spectrum of protein glycoforms is critical to understanding their functional roles. We developed the Differential Melting Voltage approach using tandem-ion mobility/tandem-mass spectrometry and applied […]
  Mengqi Chai
• Introduction to “Biomolecular Technologies” August 18, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB90031J, Editorial Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sheel C. Dodani, Ariel FurstSheel C. Dodani and Ariel Furst introduce the RSC Chemical Biology themed collection on Biomolecular Technologies.To cite this article before page numbers are assigned, use the DOI form of […]
  Sheel C. Dodani
• Characterization of Nuclease Stability and Poly(A)-binding Protein Binding Activity of Chemically Modified Poly(A) Tail for in vivo Applications† August 18, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00137D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Atsushi Hashimoto, Hiroto Iwai, Yuma Kunitomo, Ittoku Kikuchi, Keiko Kobayashi, Kazuhiro Soshiroda, Hiromi Aman, Yasuhisa Shiraishi, Satoshi Uchida, Hiroki Yamada, Yasuaki Kimura, Junichiro Yamamoto, Hiroshi AbeThe poly (A) tail plays a crucial role […]
  Atsushi Hashimoto
• Copper-catalysed azide–alkyne cycloaddition on live M13 bacteriophage for expanding the molecular diversity of phage-displayed peptide libraries August 13, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00140D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Olabode Dawodu, Cody A. White, Caitlin Specht, Alejandro Tapia, Jeffery M. TharpExpanding the diversity of phage-displayed peptides using genetic code expansion and chemical post-translational modification.To cite this article before page numbers are assigned, […]
  Olabode Dawodu
• Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography August 12, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00041F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Edward A FitzGerald, Daniela Cederfelt, Daria Kovryzhenko, Pierre Boronat, Bjarte A. Lund, Doreen Dobritzsch, Sven Hennig, Pablo Porragas Paseiro, Iwan de Esch, U. Helena DanielsonAnalysis of ligand-induced structural changes in proteins is challenging […]
  Edward A FitzGerald
• Development of a silicon phthalocyanine analogue for near-infrared photoimmunotherapy and its application to HTLV-1-infected leukemic cells August 4, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00150A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yoshikazu Fuse, Eita Sasaki, Masaharu Tamaki, Shunto Kawamura, Hisashi Ohno, Sota Yamada, Masahiro Yasunaga, Hideo Takakura, Hirofumi Hanaoka, Hisataka Kobayashi, Hideki Nakasone, Kenjiro HanaokaWe developed SiPc-1, an IR700 analog, as a photoactivatable near-infrared […]
  Yoshikazu Fuse