RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Introduction to “Endocytosis and cellular delivery” March 26, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB90009G, Editorial Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexander Kros, Georgina Such, Vincent M. RotelloAlexander Kros, Georgina Such, and Vincent Rotello introduce the RSC Pharmaceutics and RSC Chemical Biology themed collection on Endocytosis and cellular delivery.To cite this article before page […]
  Alexander Kros
• Heck-type C-glycosylations in the synthesis of artificial nucleotides and functional nucleic acids March 26, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00078A, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Robert Doerrenhaus, Andre Zenz, Stephanie Kath-SchorrAdvances in nucleic acid chemistry have driven the development of a huge variety of artificial nucleobases. The synthesis of the glycosidic bond towards nucleosides still remains a […]
  Robert Doerrenhaus
• Lipid droplet dynamics in metabolic regulation March 25, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00081A, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ralf Weiskirchen, Sabine Weiskirchen, Amedeo LonardoLipid droplets (LDs) are ubiquitous intracellular organelles that store neutral lipids such as triacylglycerols and sterol esters within a phospholipid monolayer decorated by a specialized proteome. Far […]
  Ralf Weiskirchen
• Synthesis and properties of L-lyxo-thioBsNA-pyrimidine nucleoside: a sulfur-containing analogue of boat-shaped pyranosyl nucleic acid March 25, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00034G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Miyu Ito, Suguru Matsumoto, Natsuki Yokota, Hidekazu Hiroaki, Tetsuya KodamaL-lyxo-thioBsNA, a boat-shaped nucleic acid (BsNA) analogue designed to enhance hydrophobicity – a property strongly influencing its physical characteristics – was synthesized.To cite this […]
  Miyu Ito
• Mutagenesis-Based Evolution Enables Rapid Retargeting of L-Aptamers for Structured RNA Recognition March 25, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00057F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xuan Han, Tyler Guilbault, Jonathan SczepanskiMirror-image L-(deoxy)ribose nucleic acid aptamers (L-aptamers) enable high-affinity, selective recognition of native structured RNAs via shape-based, cross-chiral interactions rather than Watson–Crick base pairing. However, achieving this level of […]
  Xuan Han
• Guanine Base Modifications in Antisense Oligonucleotides Mitigate Acute Central Nervous System Toxicity March 24, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00316D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maho Katsuyama, Taiki Matsubayashi, Ying Yang, Lei Mon Su Su, Takayuki Kuroda, Kie Yoshida-Tanaka , Rintaro Iwata Iwata Hara, Takeshi Yamada, Ui-Tei Kumiko, Kotaro YoshiokaAntisense oligonucleotides (ASOs) are recognized as promising therapeutic agents […]
  Maho Katsuyama
• Facilitated DNA damage repair as an emerging therapeutic strategy for inflammatory and fibrotic diseases March 23, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00327J, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maurice Michel, Nayere Taebnia, Volker M. LauschkeDNA damage arising from metabolic stress, oxidative injury, and impaired genome maintenance emerges as a common driver for chronic inflammatory and fibrotic diseases across multiple organs.While […]
  Maurice Michel
• Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity March 20, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00038J, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jayanta Kundu, Dhrubajyoti Datta, Masaaki Akabane-Nakata, Soham Mandal, Monika Krampert, Martin Egli, Muthiah Manoharan5′-(E)- and 5′-(Z)-vinylphosphonate carbocyclic DNA and 5′-(E)-vinylphosphonate 2′- and 3′-O-methyl carbocyclic RNAs were incorporated at 5′ termini of antisense strands […]
  Jayanta Kundu
• Investigations into linker effects of DNA–VHL ligand conjugates by multiplexed affinity measurements using focal molography March 20, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00011H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pascal Raschke, Simona Notova, Volker Gatterdam, Andreas Frutiger, Andreas BrunschweigerWe measured the affinity of linker-diversified DNA–PROTACs to VHL by focal molography. Our analysis validates multiplexed affinity measurements and identifies hydrophobicity of the linker […]
  Pascal Raschke
• Development of PROTACs for targeted degradation of oncogenic TRK fusions March 18, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D6CB00008H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Saurav Kumar, Jiewei Jiang, Mia S. Donald-Paladino, Joy Chen, Andrea Gutierrez, Alexander J. Federation, Frank Szulzewsky, Eric C. Holland, Fleur M. Ferguson, Behnam NabetJWJ-01-378 recruits cereblon (CRBN) to induce potent and selective degradation […]
  Saurav Kumar