RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• An AKR1C3-activated kinase inhibitor prodrug December 19, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00219B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhengnian Li, Michael Martinez, Woong Sub Byun, Anuradha Thathireddy, Tian Qiu, Yaning Wang, Leon Katzengruber, Ani Chouldjian, Wenchao Lu, Wenzhi Ji, Jianwei Che, Tinghu Zhang, Stephen M. Hinshaw, Nathanael S. GrayEnzymatically activated prodrugs […]
  Zhengnian Li
• Tuning the efficiency of molecular probes via quinone methide-based in situ labeling December 17, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00138B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zachary Rabinowitz, Seyedehalaleh Anvar, Jun Liu, Zixin Chen, Yuzhao Zhang, Chao Cui, Ashton Sigler, Lina CuiIn this work, we tuned quinone-methide based fluorescent probes containing different phenol linker modifications using two logical chemical […]
  Zachary Rabinowitz
• Backbone engineering in the hydrophobic core of villin headpiece December 17, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00269A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuhan Lin, Ryley M. David, Dyllan M. Amin, Shane W. J. Osborne, W. Seth HorneEngineering backbone composition in the hydrophobic core of the miniprotein villin headpiece yields a variant with ∼40% of its […]
  Yuhan Lin
• Expanding the actinomycetes landscape for phosphonate natural products through genome mining December 16, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00254K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alina Zimmermann, Shu-Ning Xia, Julia Moschny, Juan Pablo Gomez-Escribano, Judith Boldt, Ulrich Nübel, Imen Nouioui, Janina Krause, Mattis Kreins Irle, William W. Metcalf, Chambers C. Hughes, Yvonne MastScreening 940 genome-sequenced actinomycetes revealed 54 […]
  Alina Zimmermann
• Contributors to the 2025 RSC Chemical Biology Emerging Investigators Collection December 16, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB90052B, Profile Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.This article profiles the early career researchers whose work features in the RSC Chemical Biology Emerging Investigators Collection 2025.To cite this article before page numbers are assigned, use the DOI form of citation […]
• Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase December 9, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00278H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mia E. Foran, Y. T. Candace Ho, Józef R. Lewandowski, Matthew JennerScanning mutagenesis reveals the basis for molecular recognition between AT and ACP domains in fungal hrPKSs, providing a structural model for the […]
  Mia E. Foran
• Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue DEAtC December 7, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00243E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ana Shalamberidze, Harrison R. Pearce, Andrew L. Cooksy, Byron W. PurseIn solution and single-stranded DNA, DEAtC predominantly adopts a weakly emissive thymine-like tautomer, whereas base pairing with guanine or inosine stabilizes its bright […]
  Ana Shalamberidze
• A nonavalent BODIPY with a multivalent arrangement of α-mannosides enables lectins recognition in fluorescence-based assays December 5, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00190K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Edvin Purić, Giacomo Biagiotti, Jacopo Tricomi, Janez Mravljak, Stefano Cicchi, Marco Laurati, Yvette van Kooyk, Fabrizio Chiodo, Iztok Urbancic, Marko Anderluh, Barbara RichichiWe report here on the use of the Tris-BODIPY-OH as a […]
  Edvin Purić
• Protein Mannosylation in Actinobacteria an Enigmatic Post-translational Modification December 5, 2025
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00270B, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cameron B King, Warren WakachukProtein glycosylation is a very common post-translational modification seen in all branches of biology. The functional roles for protein glycosylation are many and varied, essential in eukaryotes but […]
  Cameron B King
• DNA-programmed bispecific peptide assemblies for delivering cytotoxic payload to cells expressing EGFR and MET receptors December 3, 2025
  RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00238A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Pritam Ghosh, Huyen Dinh, Oliver SeitzInteractions of bispecific DNA–peptide complexes with EGFR and MET on A549 cells showed a marked distance-affinity profile. The conditional cytotoxicity of constructs armed with auristatins is contingent on […]
  Pritam Ghosh