RSC Chemical Biology

RSC – RSC Chem. Biol. latest articles

• Gamma-FIT-PNAs as sensitive RNA probes January 20, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00292C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Manoj Kumar Gupta, Salam Maree, Eylon Yavinγ-modified FIT-PNA probes enhance brightness and binding affinity to RNA.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]
  Manoj Kumar Gupta
• Double-hit approach for novel glycoconjugates combining cytoplasmic glycoengineering and selective chemistry January 15, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00320B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Elena Palmieri, Valentina Monaci, Salvatore Durante, Paola Cescutti, Francesca Micoli, Gianmarco GasperiniIn our work we have combined cytoplasmic glycoengineering and chemical conjugation for the development of novel selective glycoconjugates, with the aim to […]
  Elena Palmieri
• Signatures of native-like glycosylation in RNA replicon-derived HIV-1 immunogens January 12, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00165J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Himanshi Chawla, Jacob T. Willcox, Grace M. Hayes, Murillo Silva, Wen-Hsin Lee, Gabriel Ozorowski, John Butler, Paul F. McKay, Robin J. Shattock, Andrew Ward, Darrell J. Irvine, Max CrispinRNA-based vaccines have emerged as […]
  Himanshi Chawla
• Impact of Irreversible and Reversible Covalent Inhibitors on Structural Dynamics of Target Proteins January 8, 2026
  RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00230C, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ruchira Basu, Steven FletcherProteins form complex networks critical to various biological processes; many become involved in disease-related pathologies -only a subset of these proteins are considered to be druggable by conventional, non-covalent […]
  Ruchira Basu
• Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation January 5, 2026
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB90053K, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael J. Bond, Craig M. CrewsTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
  Michael J. Bond
• An AKR1C3-activated kinase inhibitor prodrug December 19, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00219B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhengnian Li, Michael Martinez, Woong Sub Byun, Anuradha Thathireddy, Tian Qiu, Yaning Wang, Leon Katzengruber, Ani Chouldjian, Wenchao Lu, Wenzhi Ji, Jianwei Che, Tinghu Zhang, Stephen M. Hinshaw, Nathanael S. GrayEnzymatically activated prodrugs […]
  Zhengnian Li
• Backbone engineering in the hydrophobic core of villin headpiece December 17, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00269A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuhan Lin, Ryley M. David, Dyllan M. Amin, Shane W. J. Osborne, W. Seth HorneEngineering backbone composition in the hydrophobic core of the miniprotein villin headpiece yields a variant with ∼40% of its […]
  Yuhan Lin
• Protein mannosylation in actinobacteria an enigmatic post-translational modification December 5, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00270B, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Cameron B. King, Warren W. WakarchukProtein glycosylation is a very common post-translational modification seen in all branches of biology.To cite this article before page numbers are assigned, use the DOI form of […]
  Cameron B. King
• A nonavalent BODIPY with a multivalent arrangement of α-mannosides enables lectins recognition in fluorescence-based assays December 5, 2025
  RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00190K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Giacomo Biagiotti, Edvin Purić, Jacopo Tricomi, Janez Mravljak, Stefano Cicchi, Marco Laurati, Yvette van Kooyk, Fabrizio Chiodo, Iztok Urbančič, Marko Anderluh, Barbara RichichiWe report here a multivalent fluorescent glycoprobe useful to interrogate carbohydrate–lectin […]
  Giacomo Biagiotti
• A novel SadP-scFv UCHT1 lectibody activates T cells and mediates lysis of Burkitt's lymphoma cells November 20, 2025
  RSC Chem. Biol., 2026, 7,81-97DOI: 10.1039/D5CB00027K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jana Tomisch, Jonas Gräber, Olga N. Makshakova, Pavel Salavei, Francesca Rosato, Sarah Frisancho Mariscal, Annabelle Varrot, Anne Imberty, Winfried RömerWe describe the design and characterization of a novel SadP-scFv UCHT1 lectibody, a fusion protein […]
  Jana Tomisch