RSC – RSC Chem. Biol. latest articles- Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model March 30, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00312H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Burcu Bestas, H. Yesid Estupiñán, Qing Wang, Shabnam Kharazi, Chenfei He, Dara K. Mohammad, Dhanu Gupta, Oscar P. B. Wiklander, Taavi Lehto, Karin E. Lundin, Anna Berglöf, Mikael C. I. Karlsson, Frank Abendroth, […]Burcu Bestas
- Enzyme-mediated proximity labeling reveals the co-translational targeting of DLGAP5 mRNA to the centrosome during mitosis March 26, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D4CB00155A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gang Wang, Mo Li, Peng ZouSubcellular RNA localization is a conserved mechanism in eukaryotic cells and plays critical roles in diverse physiological processes including cell proliferation, differentiation, and embryo development. Nevertheless, the characterization […]Gang Wang
- 3′-O-β-Glucosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase March 25, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00026B, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonathan Peter Dolan, Tessa Keenan, Aisling Ni Cheallaigh, Martin A Fascione, Gavin John MillerNucleoside analogue therapeutics have a proven capability within drug discovery as antiviral and antineoplastic agents. However, their efficacy can be […]Jonathan Peter Dolan
- SYNTHETIC BIOLOGY ROUTES TO NEW AND EXTINCT NATURAL PRODUCTS March 21, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00047E, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. SimpsonRecent developments in genome sequencing and genetic engineering have revolutionised elucidation of biosynthetic pathways in bacteria and fungi and allowed production of new natural products and engineered strains with optimised...The […]Thomas J. Simpson
- Thiophosphate Bioisosteres of Inositol Hexakisphosphate Enhances Binding Affinity and Residence Time to Bacterial Virulence Factors. March 20, 2025RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D4CB00228H, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Rebecca Cummer, Garvit Bhatt, Lauren M. Finn, Bettina G. Keller, Bhushan Nagar, Bastien CastagnerInositol phosphates are essential for mammalian cell signalling with critical roles in cellular processes. The fully phosphorylated inositol phosphate, myo-inositol […]Rebecca Cummer
- Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases March 19, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D5CB00010F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chiranjeevi Pasala, Chander S. Digwal, Sahil Sharma, Shujuan Wang, Alessia Bubula, Gabriela ChiosisAberrant phosphorylation drives epichaperome formation, transforming chaperones into scaffolding platforms that rewire PPI networks. Epichaperome disruptors normalize PPI networks, enabling […]Chiranjeevi Pasala
- Peptide-mediated display of Tau-derived peptide for construction of microtubule superstructures March 19, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00290C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hiroshi Inaba, Daichi Kageyama, Soei Watari, Mahoko Tateishi, Akira Kakugo, Kazunori MatsuuraMicrotubule superstructures including doublet microtubules were constructed by displaying Tau-derived peptide on the surface of microtubules using cationic KA7 peptide.To cite this […]Hiroshi Inaba
- Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments March 17, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00291A, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Winnifrith, Steven R. Brown, Piotr Jedryszek, C. Grant, Philip E. Kay, Adam M. Thomas, Jacob D. Bradbury, Thomas Lanyon-HoggThis work describes the rapid optimisation of a new fluorescence-based assay for RecBCD enzyme […]Adam Winnifrith
- Real-time bioluminescence imaging of nitroreductase in breast cancer bone metastasis March 14, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00310A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kang Lu, Mengxi Zhang, Zuotong Tian, Han XiaoWe developed a nitroreductase-sensitive bioluminescent probe QTZ-NTR. In a breast cancer bone metastasis model, QTZ-NTR detects elevated nitroreductase in hypoxic bone tumors and monitors its dynamic […]Kang Lu
- The role of water in mediating DNA structures with epigenetic modifications, higher-order conformations and drug–DNA interactions March 14, 2025RSC Chem. Biol., 2025, Advance ArticleDOI: 10.1039/D4CB00308J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Roshan Satange, Ming-Hon HouThis review explores the role of water in canonical and non-canonical DNA structures, highlighting water-mediated interactions in small molecule groove binding, intercalation, and recent advances in studying water–nucleic acid […]Roshan Satange
- Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model March 30, 2025
