RSC – RSC Chem. Biol. latest articles- Mixed squaramide thioesters as phosphate group analogues for non-competitive antagonists of the phospholipid-sensing G protein-coupled receptor GPR55 April 23, 2026RSC Chem. Biol., 2026, Advance ArticleDOI: 10.1039/D5CB00231A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Junpei Abe, Xianyue Huang, Nozomi Ishii, Itaru Imayoshi, Yoshio Hirabayashi, Ichiro Matsuo, Hiroyuki Kamiguchi, Yukishige Ito, Adam T. Guy, Peter GreimelHigh-affinity inhibitors of specific receptors are a valuable tool to elucidate cellular signaling, […]Junpei Abe
- Development of a Spectrophotometric Assay for High-Throughput Screening and Mechanistic Characterization of Glucose-1-Phosphate Thymidylyltransferase Inhibitors April 23, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00002A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bronwyn E Rowland, Jesse C Fuller, David L JakemanThe sugar β-L-rhamnose is often a conserved component of bacterial polysaccharide capsules, an extracellular structure featured in many drug-resistant, pathogenic bacteria. The β-L-rhamnose biosynthetic enzymes […]Bronwyn E Rowland
- De novo acyl carrier proteins display structure-independent modification and sequence novelty April 23, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00148J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael Andrés Herrera, Grace King, Zoe Ozols, Gioele Tiburtini, Nicoletta Schiavo, Francesca Spyrakis, Louise Charkoudian, Dominic James CampopianoAcyl carrier proteins (ACPs) are dynamic, structurally conserved α-helical proteins central to many primary and secondary […]Michael Andrés Herrera
- Igalan Attenuates Sepsis-Induced Inflammation through Covalent Targeting of the NLRP3 Inflammasome Pathway April 22, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D5CB00280J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chengchen Hou, Yang Chen, Wenjie Bi, Lin Gao, Simiao Yu, Xiaowen Zhang, Zekun Chen, Tiantian Wei, Dilnoza Dusmatova, Rimma F Мukhamatkhanova, Ildar D Sham'yanov E, Liwen Han, Zhi-Yuan Lu, Hua Wang, Nilufar Z. […]Chengchen Hou
- Backbone N-Heteroatom Substitution as a Strategy to Enhance Peptide Proteolytic Stability April 22, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00061D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Avraz F Anwar, Natalia Cano-Sampaio, Juan Del VallePeptide-based ligands are well-suited to engage large biomolecular surfaces but are often limited by rapid proteolytic degradation in biological environments. Backbone modification offers a direct means […]Avraz F Anwar
- Decoding Protein–Phospholipid Interaction Networks in Cancer: The Role of Acyl-Chain Remodeling April 22, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00015K, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Berit Blume, Grace Potter, Carsten Schultz, Andrew EmiliLipids, particularly phosphoinositides, are increasingly recognized as important markers and causal regulators in cancer progression. Less appreciated, however, are the functional consequences of changes in […]Berit Blume
- Strategies to Overcome Hepatic Clearance of Endogenous Proteins – Molecular and Formulation Approaches April 21, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00041J, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kirstin Meiners, Tobias Stepic, Lorenz Meinel, Tessa LühmannThe medical use of biologics is often limited by rapid elimination from circulation. This review explores formulation strategies for enhancing the pharmacokinetic profiles of therapeutic […]Kirstin Meiners
- Methylene insertion reveals importance of phosphate-phosphate distance in DNase I cleavage April 20, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00024J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ayano Nagaya, Kohji Seio, Yoshiaki MasakiDNase I is a major endonuclease in human serum that cleaves double-stranded DNA. While its activity has been characterized for sequence preference and structural requirements, the effects of […]Ayano Nagaya
- Enhancing mRNA Stability and Translational Potential Through Tailored Modifications at the 3' End April 16, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00033A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Olga Perzanowska, Joanna Kowalska, Jacek JemielityPoly(A) tails regulate mRNA turnover and translation through multiple RNA–protein interactions, and deadenylation is the initiating step of the major cytoplasmic decay pathways. Here, we report a simple […]Olga Perzanowska
- RNA-binding Landscape of Amiloride: Large-scale Profiling and Structural Basis of U–U Mismatch Recognition April 14, 2026RSC Chem. Biol., 2025, Accepted ManuscriptDOI: 10.1039/D6CB00055J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kosuke Tsuzuki, Kazumitsu Onizuka, Momo Okada, Ryosuke Nagasawa, Emi Miyashita, Kaoru R. Komatsu, Hirohide Saito, Jiro Kondo, Fumi NagatsugiAmiloride possesses a characteristic chemical scaffold capable of recognizing uracil (U) through three complementary hydrogen […]Kosuke Tsuzuki
- Mixed squaramide thioesters as phosphate group analogues for non-competitive antagonists of the phospholipid-sensing G protein-coupled receptor GPR55 April 23, 2026
