RSC – Nat. Prod. Rep. latest articles- A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids Tháng 10 14, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00053J, Review ArticleMarcel Kulike-Koczula, Dominik Heimann, Tobias Eulberg, Daniel Kohnhäuser, Roderich D. Süssmuth, Mark BrönstrupThis article summarizes insights on a new class of antibiotics defined by albicidins and cystobactamids. It presents their biosynthesis, total synthesis and lead optimization, the mechanisms of action and resistance, and the antibiotic properties.To cite […]Marcel Kulike-Koczula
- Correction: Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ Tháng 10 8, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP90039E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel JasparsTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Federica Casolari
- Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis Tháng 9 30, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00052A, Review ArticleBodou Zhang, Jingwen Zhao, Sheng Li, Hong Liang, Xiaojiang Hao, Yu ZhangThis review comprehensively outlines 135 natural ryanodane diterpenes (1948–2025), covering their botanical sources, structural diversity, chemical synthesis, and key bioactivities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Bodou Zhang
- Hot off the Press Tháng 9 30, 2025Nat. Prod. Rep., 2025, 42,1646-1650DOI: 10.1039/D5NP90038G, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as aragezolone from Auricularia cornea.The content of this RSS Feed (c) The Royal Society of ChemistryRobert A. Hill
- Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives Tháng 9 29, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00045A, Review ArticleMartinus de Kruijff, Sebastian Götze, Christine BeemelmannsMetallophores are vital for microbial survival as they mediate metal bioavailability. Yersiniabactin-type metallophores are unique in biosynthesis and structure, with specialized functions that support immune evasion, nutrient acquisition, and niche colonization.To cite this article before page numbers are assigned, use the […]Martinus de Kruijff
- Engineering microbiomes for natural product discovery and production Tháng 9 23, 2025Nat. Prod. Rep., 2025, Advance ArticleDOI: 10.1039/D5NP00038F, Highlight Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francesco Del Carratore, Rainer BreitlingThe exciting advancements in multi-omics, genetic engineering and computational tools are paving the way for the engineering of synthetic communities for the discovery and production of natural products. Created […]Francesco Del Carratore
- para-Quinone methides in natural product biosynthesis Tháng 7 31, 2025Nat. Prod. Rep., 2025, 42,1676-1689DOI: 10.1039/D5NP00044K, HighlightJie Gao, Qibin Chen, Qi ZhangThis highlight focuses on nature's strategic use of highly reactive para-quinone methides (p-QMs) as key intermediates in natural product biosynthesis.The content of this RSS Feed (c) The Royal Society of ChemistryJie Gao
- Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products Tháng 7 31, 2025Nat. Prod. Rep., 2025, 42,1717-1746DOI: 10.1039/D5NP00030K, Review ArticleJi-Wei Sang, Yu Zhang, Zhimin Hu, Jinxin Wang, Wei-Dong ZhangAlkene-containing natural products (NPs) are abundantly present in plants, animals, and microorganisms.The content of this RSS Feed (c) The Royal Society of ChemistryJi-Wei Sang
- Semi-synthesis in the exploration of opioid-targeting natural products Tháng 7 29, 2025Nat. Prod. Rep., 2025, 42,1664-1675DOI: 10.1039/D5NP00029G, Highlight Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andrew P. RileyChemically modifying a natural product can be a powerful tool for studying and optimizing its biological activity. This highlight presents recent examples of applying this approach to investigate natural products that target […]Andrew P. Riley
- Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions Tháng 7 27, 2025Nat. Prod. Rep., 2025, 42,1690-1716DOI: 10.1039/D5NP00028A, Review ArticleRui Liu, Xiao-Ping Peng, David J. Newman, Diane Purchase, Gang Li, Souvik KusariThis review offers a comprehensive analysis of epigenetics and its crucial role in the production of secondary metabolites by endophytic fungi. Strategic epigenetic modulation could enhance drug discovery initiatives involving fungal endophytes.The content of this RSS […]Rui Liu
- Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides Tháng 7 15, 2025Nat. Prod. Rep., 2025, 42,1622-1638DOI: 10.1039/D5NP00042D, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shumpei AsamizuThis highlight focuses on the recent advances in the discovery and biosynthesis of bioactive lipopeptide natural products derived from ribosomally synthesized and post-translationally modified peptides.The content of this RSS Feed (c) The […]Shumpei Asamizu
- Natural products targeting the metabolism of amino acids: from discovery to synthetic development Tháng 7 10, 2025Nat. Prod. Rep., 2025, 42,1575-1621DOI: 10.1039/D5NP00039D, Review ArticleHyun Su Kim, Ahmed H. E. Hassan, Kyuho Moon, Jaehoon SimAmino acid metabolism is essential to homeostasis, immune regulation, and disease. This review highlights natural products that modulate these metabolic pathways and outlines synthetic strategies to enhance their therapeutic potential.The content of this RSS Feed (c) The Royal […]Hyun Su Kim
- Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity Tháng 7 7, 2025Nat. Prod. Rep., 2025, 42,1651-1663DOI: 10.1039/D5NP00008D, HighlightYuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu, Yihua ChenDiscovery methods of microbial natural products (NPs) evolve with technological progress. This highlight article focuses on representative methods that achieve targeted mining by simultaneously predicting the structure and activity of NPs.The content of this […]Yuwei Zhang
- Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications Tháng 6 26, 2025Nat. Prod. Rep., 2025, 42,1489-1506DOI: 10.1039/D5NP00027K, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D. Keasling, Byung-Kwan ChoSynthetic protein interfaces enable programmable assembly of PKS and […]Gahyeon Kim
- The ballet of nature: the interconvertible isomerisation of natural products Tháng 6 22, 2025Nat. Prod. Rep., 2025, 42,1548-1574DOI: 10.1039/D5NP00019J, Review ArticleZe-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang LouThis review comprehensively outlines the origins and chemical classifications of paired interconvertible isomers found in nature, including positional, tautomeric, geometric, optical, and conformational isomerism.The content of this RSS Feed (c) The Royal Society of ChemistryZe-Jun Xu
- Natural products in antiparasitic drug discovery: advances, opportunities and challenges Tháng 6 11, 2025Nat. Prod. Rep., 2025, 42,1419-1458DOI: 10.1039/D5NP00007F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaofei Shang, Lixia Dai, Xinyuan Cao, Yudong Ma, Ilgekbayeva Gulnaz, Xiaolou Miao, Xiuhui Li, Xiaorong YangIn this review, we discuss the strategies used for developing drugs from natural resources and mainly describe the […]Xiaofei Shang
- Exploring microbial natural products through NMR-based metabolomics Tháng 6 11, 2025Nat. Prod. Rep., 2025, 42,1459-1488DOI: 10.1039/D4NP00065J, Review ArticleDe-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng WuNMR-based metabolomics—whether applied independently or harmonized with genomics—offers a potent lens into microbes' chemical repertoire. The judicious integration of artificial intelligence (AI) further amplifies the potential of this advanced methodology, ushering in new frontiers for microbial natural […]De-Gao Wang
- Trends in metabolite discovery from Actinomycetes Tháng 6 8, 2025Nat. Prod. Rep., 2025, 42,1533-1547DOI: 10.1039/D4NP00075G, Review ArticlePaolo Monciardini, Matteo Simone, Marianna Iorio, Sonia I. Maffioli, Margherita Sosio, Stefano DonadioActinomycetes continue to provide new molecules at a steady rate. Here we analyze the contribution of four approaches to the discovery of new metabolites, and which strategies are more effective at yielding structurally original molecules.The content […]Paolo Monciardini
- Technological developments driving industrial natural product discovery Tháng 6 3, 2025Nat. Prod. Rep., 2025, 42,1507-1532DOI: 10.1039/D4NP00072B, Review ArticleRichard Lewis, Richard Hammond, Mark Wilkinson, Nick AllenbyA new era of antimicrobial discovery: reviewing the limits of traditional methods and the potential for new techniques to discover from previously inaccessible biosynthetic diversity.The content of this RSS Feed (c) The Royal Society of ChemistryRichard Lewis
- A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids Tháng 10 14, 2025
