Natural Product Reports

RSC – Nat. Prod. Rep. latest articles

• Highlights of cyanobacterial metabolites reported between 2021–2024 Tháng 3 16, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00076A, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Simon Sieber, Elisabeth M.-L. JanssenThis review provides an overview of newly identified cyanobacterial metabolites from 2021 to 2024. The discovery of specific natural products is discussed.To cite this article before page numbers […]
  Simon Sieber
• Glucose 6-phosphate: the diversity of C-methylation in sugar moieties within natural product biosynthesis Tháng 3 16, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00071H, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ziruo Zou, Michael MüllerDiverse methylation of sugar units by SAM-dependent C-methyltransferases in natural product biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]
  Ziruo Zou
• Decision making by modular polyketide synthases and implications for genetic engineering Tháng 3 13, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D6NP00010J, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kira J. WeissmanThis review details the many choices underlying faithful biosynthesis of complex polyketides in bacteria, and highlights the implications for genetic engineering aiming to generate novel derivatives.To cite this article before […]
  Kira J. Weissman
• Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computational NMR method Tháng 3 10, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00088B, HighlightSrinivas Beduru, Andrei G. KutateladzeThis Highlight article describes a personal selection of recent misassigned structures of NPs and their revision with the aid of DU8ML, an ML-augmented DFT method for fast and accurate calculations of NMR parameters, mostly covering 2018 to 2025.To cite this article before page numbers […]
  Srinivas Beduru
• Quinic acid as a chiron in total synthesis Tháng 3 3, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00087D, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Manuel J. Verganista, Iago C. Vogel, Nuno R. CandeiasQuinic acid is a versatile chiral building block in asymmetric synthesis, enabling diverse natural products and bioactive compounds. This review highlights four decades of […]
  Manuel J. Verganista
• Synthetic biology for heterologous expression and engineering of fungal polyketide synthases Tháng 3 2, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00020C, HighlightSidharth Jayachandran, Adrian Enrique Gadar-Lopez, Ling Chen, Kasper Krunderup Jakobsen, Coco Xie, Therese Horch, Jay D. Keasling, Pablo Cruz-MoralesPolyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]
  Sidharth Jayachandran
• Microbial production of C7–C9 aromatic building blocks for the production of natural products Tháng 2 23, 2026
  Nat. Prod. Rep., 2026, Advance ArticleDOI: 10.1039/D5NP00068H, Review ArticleQiaoqiao Dai, Jiaqi Xu, Jing Wu, Xiaomin Li, Cong Gao, Guipeng Hu, Liming LiuThis review surveys representative C7–C9 aromatic compounds, outlining their microbial biosynthetic pathways, key metabolic challenges, and recent advances in metabolic engineering for their microbial production.To cite this article before page numbers are assigned, use […]
  Qiaoqiao Dai
• Editorial: Microbial host and metabolic engineering for natural product discovery and production Tháng 2 16, 2026
  Nat. Prod. Rep., 2026, 43,279-280DOI: 10.1039/D6NP90006B, EditorialAlessandra S. Eustaquio, Eriko Takano, Tobias A. M. GulderAlessandra Eustaquio, Eriko Takano and Tobias Gulder introduce the Natural Product Reports themed issue on microbial host and metabolic engineering for natural product discovery and production.The content of this RSS Feed (c) The Royal Society of Chemistry
  Alessandra S. Eustaquio
• Correction: Progress in the discovery and development of anticancer agents from marine cyanobacteria Tháng 2 9, 2026
  Nat. Prod. Rep., 2026, 43,391-392DOI: 10.1039/D6NP90002J, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hendrik Luesch, Emma K. Ellis, Qi-Yin Chen, Ranjala RatnayakeThe content of this RSS Feed (c) The Royal Society of Chemistry
  Hendrik Luesch
• Hot off the Press Tháng 2 9, 2026
  Nat. Prod. Rep., 2026, 43,281-285DOI: 10.1039/D6NP90001A, Hot off the Press ArticleRobert A. Hill, Andrew SutherlandA personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as candindole A from Aspergillus candidus.The content of this RSS Feed (c) The Royal Society of Chemistry
  Robert A. Hill
• Engineering microbiomes for natural product discovery and production Tháng 9 23, 2025
  Nat. Prod. Rep., 2026, 43,301-312DOI: 10.1039/D5NP00038F, Highlight Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francesco Del Carratore, Rainer BreitlingThe exciting advancements in multi-omics, genetic engineering and computational tools are paving the way for the engineering of synthetic communities for the discovery and production of natural products. Created in […]
  Francesco Del Carratore
• Streptomyces as a versatile host platform for heterologous production of microbial natural products Tháng 9 8, 2025
  Nat. Prod. Rep., 2026, 43,371-390DOI: 10.1039/D5NP00036J, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Constanze Lasch, Maksym Myronovskyi, Andriy LuzhetskyyThis review outlines recent strategies for genome mining, synthetic refactoring, and host-based expression of natural product biosynthetic gene clusters, focusing on discovery, dereplication, and scalable production.The content of […]
  Constanze Lasch
• The development of Burkholderia bacteria as heterologous hosts Tháng 7 27, 2025
  Nat. Prod. Rep., 2026, 43,335-351DOI: 10.1039/D5NP00024F, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stephanie C. Heard, Alessandra S. EustáquioWe review Burkholderia bacterial strains that have been tested as heterologous hosts and the natural products obtained. We also compare host characteristics and their stage of development.The content […]
  Stephanie C. Heard
• Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering Tháng 7 27, 2025
  Nat. Prod. Rep., 2026, 43,352-370DOI: 10.1039/D5NP00041F, Review ArticleBiyan Chen, Emre F. Bülbül, SeoungGun Bang, Hannah A. Minas, Kenan A. J. BozhüyükThis review outlines integrated platforms combining genome mining, computational design, synthetic biology, and high-throughput screening to enable the programmable biosynthesis of tailor-made natural products.The content of this RSS Feed (c) The Royal Society of Chemistry
  Biyan Chen
• Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Tháng 7 14, 2025
  Nat. Prod. Rep., 2026, 43,286-300DOI: 10.1039/D5NP00016E, Viewpoint Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Benjamin Philmus, Nicole E. Avalon, Yousong Ding, Drew T. Doering, Alessandra S. Eustáquio, William H. Gerwick, Hendrik Luesch, Jimmy Orjala, Shaz Sutherland, Arnaud Taton, Daniel UdwaryCyanobacteria are prolific producers of bioactive natural products. In […]
  Benjamin Philmus
• Accelerating enzyme discovery and engineering with high-throughput screening Tháng 10 14, 2024
  Nat. Prod. Rep., 2026, 43,313-334DOI: 10.1039/D4NP00031E, Review Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Eray U. Bozkurt, Emil C. Ørsted, Daniel C. Volke, Pablo I. NikelRecent progress in the DBTL cycle, including machine learning, facilitated enzyme mining for biocatalysis. Automation and standardization of library construction, coupled to […]
  Eray U. Bozkurt