RSC – Lab Chip latest articles- A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks Tháng 3 29, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01171J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Delaney Ruth Gray-Scherr, Terry Ching, Katherine Beran, Sarah C Adams, Emily Davis, Abraham C.I. van Steen, Trisha Raman, Wilson W Wong, Jeroen Eyckmans, Christopher S. ChenBlood and lymphatic microvascular networks function as integrated systems […]Delaney Ruth Gray-Scherr
- A 3D-Printed Electromagnetically Actuated Microgripper System for Precision Single-Cell Manipulation Tháng 3 27, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00081A, PaperXi Chen, Qingying Ren, Wenshuo Zhao, Minhao Wang, Yining Guo, Jing Huang, Xuhui Zhao, Xinyu Lu, Yuan Liu, Haifeng XuCell manipulation is an important technique in biomedical research, yet existing micromanipulation tools still face challenges in force-control precision, multiscale adaptability, and biocompatibility. To address these limitations, this paper presents...The […]Xi Chen
- Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions Tháng 3 26, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01094B, PaperYue Yu, Tian Lin, Xiao Ye, Yupeng Wang, Rong-Rong Xiao, Baiyang Sun, Manman Zhao, Jie Song, Bo Li, Xiaobing ZhouCurrent preclinical models face challenges in recapitulating organ-level interactions affecting drug safety and there has been little investigation into drug toxicity and related DILI. We presented a pump-less gut-liver-on-chip enabling...The […]Yue Yu
- Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations Tháng 3 25, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01042J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Esra Yilmaz, Zhimeng Fan, Jason Paul Beech, Vinay Swaminathan, Jonas Olof TegenfeldtCancer cells display marked heterogeneity in size and morphology, traits long recognized in pathology as indicators of pleomorphism and poor prognosis. Yet, the […]Esra Yilmaz
- Rapid Desiccation and On-disc Rehydration of Extracellular Vesicles for Non-cryogenic Preservation Tháng 3 25, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00014B, PaperHyun-Kyung Woo, Sangjin Seo, Advitiya Mahajan, Seoyoung Lee, Seoyoon Bae, Jeremy Quintana, Changhyun Kim, Alptekin Aksan, Hakho LeeStorage options for extracellular vesicles (EVs) remain limited, constraining their clinical and research applications. Conventional low-temperature freezing (-80 °C), although the established standard, requires substantial resources and presents logistical challenges....The content of […]Hyun-Kyung Woo
- PDMS aqueous leachates exhibit acute toxicity in C. elegans Tháng 3 25, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00017G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kin Gomez, Kirill Efimenko, Jan Genzer, Adriana San MiguelPolydimethylsiloxane (PDMS), often assumed to be biocompatible, is widely used in microfluidic devices and biomedical research. Here, we systematically assess the organismal effects of PDMS network […]Kin Gomez
- Multi-Wavelength transparent microfluidic device for UV-Visible illumination and X-ray Scattering studies of Photoactive Systems Tháng 3 24, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01116G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Benedetta Marmiroli, Sumea Klokic, Barbara Sartori, Marie Reißenbüchel, Alessio Turchet, Heinz AmenitschMicrofluidic devices are increasingly used in synchrotron-based experiments to deliver and probe liquid samples, offering advantages such as minimal sample consumption and reduced […]Benedetta Marmiroli
- In vitro space of Disse model for exploration of drug induced hepatotoxicity Tháng 3 21, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01139F, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ana Mesic, Antonietta Messina, Zoe Tiprez, Benoit Charlot, Safa Mohamed Ismail, Nicolas Huang, Sakina Bensalem, Jean-Charles Duclos-Vallee, Bruno Le PioufleA human-cell-derived liver-on-a-chip model integrating tunable alginate hydrogel and LSEC–HepaRG co-culture. Recapitulates sinusoidal architecture, with […]Ana Mesic
- Correction: A gut–brain axis on-a-chip platform for drug testing challenged with donepezil Tháng 3 20, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC90130H, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francesca Fanizza, Simone Perottoni, Lucia Boeri, Francesca Donnaloja, Francesca Negro, Francesca Pugli, Gianluigi Forloni, Carmen Giordano, Diego AlbaniTo cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Francesca Fanizza
- Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production Tháng 3 20, 2026Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC01130B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hyo-il Jung, Zhaoyu Zhang, Jaejeung Kim, Jinwoo Hwang, Hyunjo Seo, Geonha Kim, Seoyeon Choi, Kyung-A HyunLipid nanoparticles (LNPs) are a key platform for nucleic acid delivery, but their industrial-scale production remains a critical bottleneck. […]Hyo-il Jung
- Tunable squeeze-activated GHz acoustofluidics for stable trapping and separation of sub-100 nm nanoparticles Tháng 3 20, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00106H, PaperYiming Liu, Wei Wei, Hang Qi, Shuaihua Zhang, Yongqi Chen, Yaping Wang, Xuexin DuanHere we propose a tunable squeeze-activated GHz acoustofluidics (TSGA) platform, which enables continuous enrichment of particles down to 50 nm and high-resolution purification of exosome subpopulations.To cite this article before page numbers are assigned, use the […]Yiming Liu
- Integrated microfluidic platform for inertial separation and encapsulation of single cells in droplets Tháng 3 19, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00085A, PaperFariba Malekpour Galogahi, Haotian Cha, Sharda Yadav, Hang Thu Ta, Nam-Trung NguyenThis study presents an integrated microfluidic device for simultaneous size-based cell separation and on-chip encapsulation into droplets at single-cell resolution, enabling streamlined processing and efficient downstream single-cell analysis.To cite this article before page numbers are assigned, use the […]Fariba Malekpour Galogahi
- Digitally programmable microfluidic valving for autonomous, high-resolution continuous chromatographic purification Tháng 3 19, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00015K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yi-Cheng Liao, Chih-Yi Huang, Yu-Chuan Tang, Cheng-Hsian Wu, Yu-Hsuan Chi, I-Wei Chen, Hsuan-Yu Mu, Ya-Hui Lin, Yunching Chen, Fu-Fei Hsu, Jen-Huang HuangA programmable, single-use protein purification platform enables contamination-free and continuous workflows for sensitive […]Yi-Cheng Liao
- Monolithic 3D-printed split-and-recombine micromixer integrated into a microfluidic concentration gradient generator Tháng 3 18, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01095K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francisco Navarro Molina, Jitendra Paliwal, Elham SalimiMonolithic 3D-printed microfluidic device integrating a SAR micromixer and concentration gradient generator, with experimental validation across a broad Reynolds number (Re) range.To cite this article before page numbers […]Francisco Navarro Molina
- Miniaturisation of Raman spectroscopy systems: from benchtop to backpocket Tháng 3 18, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00836K, Critical Review Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mike Hardy, Pooja P. Kanade, Emma Buchan, Pola Goldberg Oppenheimer, Cillian P. T. McPolin, Robert M. Bowman‘Progress of Raman systems from open-bench systems to miniaturised systems.’ Image generated with the assistance of Google […]Mike Hardy
- Microfluidic determination of minimum miscibility pressure (MMP) in dynamic CO2/n-decane flow Tháng 3 18, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00616C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Junyi Yang, Peichun Amy TsaiThis work presents a novel microfluidic method for dynamically determining the minimum miscibility pressure (MMP) of CO2–oil systems with high precision and direct visualization.To cite this article before page numbers […]Junyi Yang
- Machine learning-driven single-cell phenotyping in size-controlled microenvironments via parallel deterministic droplet microfluidics Tháng 3 17, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00839E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sangmin Lee, Steven O'Donnell, Zhangli Peng, Jae-Won ShinWe present an integrated platform combining deterministic single-cell encapsulation across multiple microgel sizes with machine-learning analysis to identify size-dependent phenotypes and predict microenvironmental confinement.To cite this article […]Sangmin Lee
- Machine learning-augmented lateral flow assays for point-of-care infectious disease diagnostics Tháng 3 17, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01124H, Critical Review Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cagla Parmaksizoglu, Isil Cakiroglu, Nazente Atceken, Eden Morales-Narváez, Ali K. Yetisen, Savas TasogluAdvances in LFAs for infectious diseases include nanomaterial engineering, CRISPR amplification, and multiplex designs for better sensitivity and quantitation. AI/ML enables […]Cagla Parmaksizoglu
- A customizable, low-cost 3D-printed device for live cell confinement imaging Tháng 3 17, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01146A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hunter Richman, Jin Ou, Manpreet Khera, Yan YuA 3D-printed, light microscopy-compatible cell confinement device that delivers precise, tunable, and uniform confinement heights while enabling live-cell imaging.To cite this article before page numbers are assigned, […]Hunter Richman
- Fluid mechanics of thin blood films to detect anemia and sickle cell disease Tháng 3 16, 2026Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00943J, PaperMahrukh A. Mir, Mahesh S. Tirumkudulu, Bhavesh RaichaWe determine the viscosity of blood from the length of blood smears. Viscosity below a threshold indicates anemia, while viscosity increase due to stiffening of red blood cells upon deoxygenation indicates sickle cell disease.To cite this article before page numbers are assigned, […]Mahrukh A. Mir
- A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks Tháng 3 29, 2026
