Lab on a Chip

RSC – Lab Chip latest articles

• An electrochemical sensor integrated lab-on-a-CD system for Phenylketonuria diagnostics Tháng Mười Hai 31, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00912F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.İpek Akyılmaz, Ergul Dilan Celebi Birand, Naim Yağız Demir, Deniz BAŞ, Caglar Elbuken, Memed DumanPhenylketonuria (PKU) is characterized by an autosomal recessive mutation in the phenylalanine hydroxylase (PAH) gene. Impaired PAH enzyme activity leads […]
  İpek Akyılmaz
• Automated Electrochemical Oxygen Sensing Using a 3D-Printed Microfluidic Lab-on-a-Chip System Tháng Mười Hai 28, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00962B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel Kaufman, Steffen Winkler, Christopher Heuer, Ahed Shibli, Alexander Snezhko, Gideon Isaac Livshits, Janina Bahnemann, Hader Ben-YoavDissolved oxygen is crucial for metabolism, growth, and other complex physiological and pathological processes; however, standard physiological models […]
  Daniel Kaufman
• A fluidic device for continuous on-line inductive sensing of proteolytic cleavages Tháng Mười Hai 26, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00657G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Fan Li, Leif Sieben, Johannes Büchler, Manuel Strahm, Pascal Poc, Matej Vizovisek, Michael G. Christiansen, Simone SchuerleProteases, an important class of enzymes that cleave proteins and peptides, carry a wealth of potentially useful information. […]
  Fan Li
• The Reversible Capillary Field Effect Transistor: A Capillaric Element for Autonomous Flow Switching Tháng Mười Hai 25, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00706A, PaperDaniel Mak, Claude Meffan, Julian Menges, Rhys Marchant-Ludlow, Azadeh Hashemi, Ciaran P. Moore, Renwick Dobson, Volker NockNew flow control elements in capillaric circuits are key to achieving ever more complex Lab-on-a-Chip functionality while maintaining their autonomous and easy-to-use nature. Capillary Field Effect Transistors valves allow for...The content of this […]
  Daniel Mak
• Engineering the acoustic field with a Mie scatterer for microparticles patterning Tháng Mười Hai 18, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00577E, PaperXingyu Jiang, yunpeng zhao, Minjie Shen, Xiao Zhou, Bin Chen, Bruce Drinkwater, Liangfei TianThe utilization of acoustic fields offers a contactless approach for microparticle manipulation in a miniaturized system, and plays a significant role in medicine, biology, chemistry, and engineering. Due to the...The content of this RSS Feed (c) […]
  Xingyu Jiang
• 3D-printed acoustic metasurface with encapsulated micro-air-bubbles for frequency-selective manipulation Tháng Mười Hai 18, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00890A, PaperMiaomiao Ji, Yukai Liu, Zheng Zhang, Rui Xu, Fanyun Pan, Ya Zhang, Rouyu Su, Minghui Lu, Xiujuan Zhang, Guanghui WangA low-frequency acoustic metasurface with PDMS-stabilized microbubbles achieves stable vibration modes, precise control over micro-object aggregation, rotation, separation, and selective trajectory manipulation through frequency-tuned excitation.To cite this article before page […]
  Miaomiao Ji
• A universal framework for design and manufacture of deterministic lateral displacement chips Tháng Mười Hai 18, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00838C, PaperAryan Mehboudi, Shrawan Singhal, S. V. SreenivasanDespite being a high-resolution separation technique, deterministic lateral displacement (DLD) technology is facing multiple challenges with regard to design, manufacture, and operation of pertinent devices. This work specifically aims at...The content of this RSS Feed (c) The Royal Society of Chemistry
  Aryan Mehboudi
• Stretchable impedance electrode array with high durability for monitoring of cells under mechanical and chemical stimulations Tháng Mười Hai 18, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00680A, PaperAri Kim, Hong Seok ju, Han-Byeol Lee, Nae Eung LeeElectrochemical impedance spectroscopy (EIS) serves as a non-invasive technique for assessing cell status, while mechanical stretching plays a pivotal role in stimulating cells to emulate their natural environment. Integrating these...The content of this RSS Feed (c) The Royal Society of […]
  Ari Kim
• An FET-Based Flexible Biosensor System For Dynamic Behavior Observation Of Lipid Membrane With Nanoparticles In Vitro Tháng Mười Hai 18, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00801D, PaperKeyi Zhu, Hanjing Lu, Qiannan Xue, Feng Zhou, Wenlan Guo, Chen Sun, Xuexin DuanNanoparticles have become a widely used material in various fields, yet their mechanism of action at the cellular level after entering the human body remains unclear. Accurate observing the effect...The content of this RSS Feed (c) […]
  Keyi Zhu
• STEPWISE ISOLATION OF DIVERSE METABOLIC CELL POPULATIONS USING SORTING BY INTERFACIAL TENSION (SIFT) Tháng Mười Hai 17, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00792A, PaperMatthew Shulman, Thomas Mathew, Aria Trivedi, Azam Gholizadeh, Charlotte Colcord, Ryan Wiley, Kiron Stephen Allen, Lakshmi Thangam, Kelsey Voss, Paul AbbyadWe present here a passive and label-free droplet microfluidic platform to sort cells stepwise by lactate and proton secretion from glycolysis. A technology developed in our lab, Sorting by […]
  Matthew Shulman
• Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell Tháng Mười Hai 17, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00817K, PaperYimin Shi, Sheng Sun, Hui Liu, Mingda Zhao, Meiyan Qin, Jinlong Liu, Jingfang Hu, Yang Zhao, Mingxiao Li, Lingqian Zhang, Chengjun HuangWe introduced a spatial TEER strategy and measured the spatial TEER of the cells cultured on a Transwell. We established a new equivalent circuit model, achieving a close […]
  Yimin Shi
• High-throughput, combinatorial droplet generation by sequential spraying Tháng Mười Hai 17, 2024
  Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00656A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rena Fukuda, Nate J CiraAdvancements in bulk and microfluidic emulsion methodologies have enabled highly efficient, high-throughput implementations of biochemical assays. Spray-based techniques offer rapid generation, droplet immobilization, and accessibility, but remain relatively underutilized, likely...The […]
  Rena Fukuda
• An agarose fluidic chip for high-throughput in toto organoid imaging Tháng Mười Hai 17, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00459K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sarah De Beuckeleer, Andres Vanhooydonck, Johanna Van Den Daele, Tim Van De Looverbosch, Bob Asselbergh, Hera Kim, Coen Campsteijn, Peter Ponsaerts, Regan Watts, Winnok H. De VosCell and developmental biology increasingly relies on tissue […]
  Sarah De Beuckeleer
• An intimal-lumen model in a microfluidic device: potential platform for atherosclerosis-related studies Tháng Mười Hai 16, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00868E, PaperFahima Akther, Dimple Sajin, Shehzahdi S. Moonshi, Jessica Pickett, Yuao Wu, Jun Zhang, Nam-Trung Nguyen, Hang Thu TaA microfluidic early atherosclerosis intimal-lumen model for in vivo-like monocyte transmigration and foam cell formation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]
  Fahima Akther
• A vascularized microfluidic model of the osteochondral unit for modeling inflammatory response and therapeutic screening Tháng Mười Hai 13, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00651H, PaperKevin D. Roehm, Irene Chiesa, Dustin Haithcock, Riccardo Gottardi, Balabhaskar PrabhakarpandianA tri-culture model of the osteochondral unit incorporating cartilage, bone, and vasculature in separate compartments that permit cell–cell interaction and have applications in the pathogenesis of osteoarthritis and screening of compounds.To cite this article before page numbers are assigned, […]
  Kevin D. Roehm
• Beveled microneedles with channel for transdermal injection and sampling, fabricated with minimal steps and standard MEMS technology Tháng Mười Hai 12, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00880D, PaperAlvise Bagolini, Nicolò G. Di Novo, Severino Pedrotti, Matteo Valt, Cristian Collini, Nicola M. Pugno, Leandro LorenzelliMicroneedles hold the potential for enabling shallow skin penetration applications where biomarkers are extracted from the interstitial fluid (ISF) and drugs are injected in a painless and effective manner.To cite this article before […]
  Alvise Bagolini
• Liquid metal electrodes enabled cascaded on-chip dielectrophoretic separation of large-size-range particles Tháng Mười Hai 12, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00942H, PaperHuichao Chai, Liang Huang, Junwen Zhu, Jialu Tian, Wenhui WangWe cascade accumulative dielectrophoretic deflection effects with passive flow fraction mechanisms for high-efficiency separation of a large range of particles, using alternative side-wall liquid metal electrode segments and bypass outlets.To cite this article before page numbers are assigned, use the […]
  Huichao Chai
• Intelligent optoelectrowetting digital microfluidic system for real-time selective parallel manipulation of biological droplet arrays Tháng Mười Hai 11, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00804A, PaperTianyi Wang, Shizheng Zhou, Xuekai Liu, Jianghao Zeng, Xiaohan He, Zhihang Yu, Zhiyuan Liu, Xiaomei Liu, Jing Jin, Yonggang Zhu, Liuyong Shi, Hong Yan, Teng ZhouAn intelligent optoelectrowetting system integrates AI-based detection and tracking to dynamically manipulate and auto-correct droplet movements. This enables precise multivariate independent microalgae cultivation in […]
  Tianyi Wang
• Injury-On-A-Chip for Modelling Microvascular Trauma-Induced Coagulation Tháng Mười Hai 11, 2024
  Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D4LC00471J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Halston Deal, Elizabeth Byrnes, Sanika Pandit, Anastasia Sheridan, Ashley Brown, Michael DanieleBlood coagulation is a highly regulated injury response that features polymerization of fibrin fibers to prevent the passage of blood from a damaged […]
  Halston Deal
• Reusable EWOD-based microfluidic system for active droplet generation Tháng Mười Hai 10, 2024
  Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00744A, PaperSuhee Park, Jaewook Ryu, Ki-Ho HanA reusable EWOD device enables rapid, precise droplet generation, reducing costs and improving control, ideal for applications like single-cell genomics and drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) […]
  Suhee Park