RSC – Lab Chip latest articles- Candyfluidics: The Art of Fabricating Micro-and Nano-fluidic Geometries using Surface-deposited Sugar Scaffolds Tháng 9 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00710K, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tochukwu D Anyaduba, J. Rodriguez-ManzanoThe adoption of miniaturization technologies, such as micro and nanofluidic systems, as a strategy for democratized healthcare in developing countries was proposed decades ago. However, regions in most need of...The […]Tochukwu D Anyaduba
- Optimizing Microfluidic Flow Cell Geometry for In-Situ Resonant Soft X-ray Characterization of Molecular Nanostructures Tháng 9 15, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00765H, PaperDevin Grabner, Terry McAfee, Cheng Wang, Matthew Marcus, Brian CollinsLiquid-phase resonant soft X-ray scattering (LP-RSoXS) is an emerging label-free technique to probe chemically resolved nanostructures of molecular or hybrid materials in liquid environments. Still, quantitative analysis is hindered by...The content of this RSS Feed (c) The Royal Society of […]Devin Grabner
- Modular bioreactor for multi-well electrical stimulation of in vitro cardiac tissue engineering constructs Tháng 9 14, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00234F, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Suh Hee Cook, Jack Twiddy, Yuan Li, Kiran M. Ali, Daxian Zha, Kaleah Gaddy, Lauren Mabe, Ke Huang, Ke Cheng, Michael Daniele, Jessica M GluckSystems for providing electrical stimulation to in vitro cell cultures […]Suh Hee Cook
- Secondary Vortex Induced by Gigahertz Acoustic Streaming and its Applications for 3D Particles Manipulations Tháng 9 14, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00640F, PaperYangchao Zhou, Haitao Zhang, Wenlan Guo, Chen Sun, Xuexin DuanAcoustic streaming serves as a fast-developing contactless tool for manipulation of micro/nanoparticles. However, traditional Eckart streaming has low manipulation precision and Rayleigh streaming only works in a very close distance...The content of this RSS Feed (c) The Royal Society of […]Yangchao Zhou
- Interplay Between Dietary Fiber, Macrophages and Colonocytes in a Microfluidic Model of Host-Microbiota Interactions in Colorectal Cancer Tháng 9 10, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00052A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Arul Jayaraman, Daniel Penarete-Acosta, Mohet Mittal, Sanjukta Chakraborty, Arum HanDietary fiber has been consistently associated with a decreased risk of colorectal cancer development. While the apoptotic effect of dietary fiber microbial fermentation products such […]Arul Jayaraman
- Micro elastofluidic liquid diode for programmable unidirectional flow control Tháng 9 10, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00438A, PaperHaotian Cha, Fariba Malekpour Galogahi , Quang Thang Trinh, Sharda Yadav, Jun Zhang, Hongjie An, Qin Li, Nam-Trung NguyenControllable liquid transport is essential for fluid regulation in wearable biosensing platforms. Particularly, unidirectional flow offers a passive, geometry-dependent strategy to direct liquid movement without external actuation. However, most previous...The content […]Haotian Cha
- Flip the chip: Trapping low number of cancer and immune cells for spheroid formation of homogeneous size Tháng 9 8, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00210A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Raphael Dezauzier, Anna Fomina, Petra S DittrichDrug tests on patient-derived tumor cells enable a personalized therapy and promise early identification of resistant cells. However, most drug tests are performed on cell monolayers that do […]Raphael Dezauzier
- Modular, open-sourced multiplexing for democratizing spatial omics Tháng 9 7, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00286A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicholas Zhang, Zhou Fang, Priyam Kadakia, Jamie Guo, Dakshin Vijay, Manoj Thapa, Samuel Dembowitz, Arash Grakoui, Ahmet F. CoskunWe develop a Python-based robot staining and imaging system compatible with Nikon widefields and Cephla spinning […]Nicholas Zhang
- Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip Tháng 9 7, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00156K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yuncheng Man, Ryan R. Posey, Haiqing Bai, Amanda Jiang, Pere Dosta, Diana Ocampo-Alvarado, Roberto Plebani, Jie Ji, Chaitra Belgur, Natalie Artzi, Donald E. IngberHuman Organ Chips as a useful preclinical tool for rapid efficacy […]Yuncheng Man
- Microfluidic synthesis of iron oxide nanoparticles for highly efficient intracellular delivery in stem cells and cancer cells Tháng 9 7, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00448A, PaperAthira Prasad, Gayathri. R, Nandhini. B, R. Jayaganthan, Srabani Kar, Tuhin Subhra SantraThis study presents a 3D-printed microfluidic device for the synthesis of uniform iron oxide nanoparticles. The synthesized nanoparticles were utilized for highly efficient delivery of biomolecules into both stem cells and cancer cells.To cite this article before […]Athira Prasad
- Rapid Pan-Cancer Detection via Label-Free Impedance Profiling of Cell-Free DNA Tháng 9 4, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00431D, PaperTejal Dube, Puja Prasad, Pragya Swami, Ankita Singh, Meenakshi Verma, Parul Tanwar, S. Chowdhury, Shalini GuptaAberrant DNA methylation is a hallmark of cancer, and plasma cell-free DNA (cfDNA) containing these abnormal methylation patterns has emerged as a promising non-invasive biomarker for pan-cancer detection. However, intrinsic...The content of this RSS […]Tejal Dube
- On-Chip Oocyte Cumulus Removal using Vibration Induced Flow Tháng 9 4, 2025Lab Chip, 2025, Accepted ManuscriptDOI: 10.1039/D5LC00414D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amirhossein Favakeh, Amir Mokhtare, Hanxue Zhang, Yi Athena Ren, Alireza AbbaspourradCumulus removal (CR), the removal of the small protective granulosa cells that surround an oocyte, is a crucial step in assisted reproductive technologies (ART). […]Amirhossein Favakeh
- Electronically controlled deprotection chemistry for multiplex enzymatic DNA synthesis on a chip with single-base resolution Tháng 9 4, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00548E, PaperLihuan Zhao, Qinzhuo Sun, Jian-Qiao Jiang, Xuezheng Wu, Yiming Dong, Dan Wu, Lin-Sheng Wu, Xin ZhaoThis work introduces an electronically controlled deprotection chemistry for multiplexed enzymatic DNA synthesis on chips. Electrochemically generated HNO2 enables single-base precision in multi-pixel arrays.To cite this article before page numbers are assigned, use the […]Lihuan Zhao
- Size-independent and automated single-colony-resolution microdroplet dispensing Tháng 9 4, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00374A, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Haemin Jung, Han Zhang, Jacob Hooper, Can Huang, Rohit Gupte, Adrian Guzman, Jeong Jae Han, Arum HanA high-precision droplet dispenser uses blank spacer droplets to separate target droplets during flow and dispensing, preventing cross-contamination […]Haemin Jung
- High-throughput multimodal optofluidic biophysical imaging cytometry Tháng 9 4, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00381D, PaperThiel Lee, Evelyn H. Y. Cheung, Kelvin C. M. Lee, Dickson M. D. Siu, Michelle C. K. Lo, Edmund Y. Lam, Ruchi Goswami, Salvatore Girardo, Kyoohyun Kim, Felix Reichel, Marketa Kubankova, Martin Kräter, Jochen Guck, Kevin K. TsiaQuantitative phase morpho-rheological (QP-MORE) cytometry simultaneously captures a collection of high-resolution biophysical […]Thiel Lee
- Organ-on-a-chip: key industry insights, challenges, and opportunities from 100+ NSF I-Corps interviews Tháng 9 3, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00426H, PerspectiveRonin-Mae Komarnisky, Shaun Wootten, Nathan Friedman, Mehdi NikkhahThis perspective offers an in-depth analysis of the organ-on-a-chip commercialization landscape, providing real-world insights from NSF I-Corps interviews that reveal the underlying challenges hindering commercial translation and industry adoption.To cite this article before page numbers are assigned, use the DOI form of […]Ronin-Mae Komarnisky
- Topographic cues regulate collective cell dynamics in curved nano/microgrooved tubular microchannels Tháng 9 3, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00368G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tatsuya Matsubara, Chris P. Miller, Chanhong Min, Chia-Yi Su, Jong Seob Choi, Chwee Teck Lim, Jude M. Phillip, Joon-wan Kim, Deok-Ho KimThis study introduces tubular microchannels with micro/nanoscale grooves, fabricated by two-photon polymerization, to […]Tatsuya Matsubara
- Tunable cell separation using a thermo-responsive deterministic lateral displacement device Tháng 9 2, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00783F, PaperZe Jiang, Yusuke Kanno, Takasi NisisakoTunability in isolating target cells of varying sizes from complex heterogeneous samples is essential for biomedical research and diagnostics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]Ze Jiang
- Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip Tháng 8 31, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00067J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Edmond A. Rogers, Tyler C. Diorio, Timothy Beauclair, Jhon Martinez, Shatha J. Mufti, David Kim, Nikita Krishnan, Vitaliy Rayz, Riyi Shi“TBI-on-a-chip” and its digital twin resolve neuronal-scale concussive forces with Alzheimer's-linked tau aberrations and […]Edmond A. Rogers
- Adhesion-based cell sorting platform using on-chip centrifugation Tháng 8 28, 2025Lab Chip, 2025, Advance ArticleDOI: 10.1039/D5LC00578G, PaperMao Otake, Takaaki Abe, Yoshiaki Ukita, Hiromi MiyoshiCentrifugal cell sorting allows label-free, high-throughput cell sorting. In this study, we discovered cell type-independent centrifugal detachment parameters by real-time centrifugation observation and focal adhesion analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]Mao Otake
- Candyfluidics: The Art of Fabricating Micro-and Nano-fluidic Geometries using Surface-deposited Sugar Scaffolds Tháng 9 15, 2025
